Search

Aurones, (Z)-2-benzylidenebenzofuran-3(2H)-ones, have proved to be promising bioactive compounds with a broad spectrum of activities including anticancer, antioxidant, antiparasitic and antibacterial activities. Aurones exhibited strong antiproliferative properties against cancer cells by acting on variable targets through different modes of action. Furoaurones, (Z)-2-benzylidenefurano[3,2-f] benzofuran-3(2H)-ones, is a class of semi synthetic compounds derived from naturally furanochromones extracted from of Ammi visnaga (L.) fruits. So, this literature review includes different biological activities of aurones and furoaurones and different methods for their synthesis. Keywords: Aurones, Furoaurones

The synthesis of different series of 6-iodo-2-phenoxymethyl 3-substituted quinazolin-4(3 H )-ones 5–17 is described. The structures of the newly synthesized compounds have been confirmed on the basis of elemental analyses, IR, 1 H NMR and mass spectral data. Preliminary testing for the in vitro antitumor activity of the synthesized compounds against MCF-7 breast cell line was carried out using Doxorubicin (IC 50 : 5.46 μmol/ml) as a reference drug. Compound 5b exhibited a remarkable antitumor activity (IC 50 : 5.49 μmol/ml) almost similar to that expressed by the reference drug, whereas compounds 7d , 12b and 6c (IC 50 : 6.23, 6.55 and 6.80 μmol/ml, respectively) showed a considerable activity.