40 results on '"Hamaguchi S"'
Search Results
2. Mathematical methods for thin film deposition simulations
- Author
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Hamaguchi, S., primary
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- 1996
- Full Text
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3. Diffuse idiopathic skeletal hyperostosis causing neck pain with dyspnea, dysphonia, and dysphagia.
- Author
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Nakagawa H and Hamaguchi S
- Subjects
- Humans, Male, Female, Middle Aged, Hyperostosis, Diffuse Idiopathic Skeletal complications, Hyperostosis, Diffuse Idiopathic Skeletal diagnostic imaging, Dysphonia etiology, Deglutition Disorders etiology, Neck Pain etiology, Neck Pain diagnostic imaging, Dyspnea etiology
- Abstract
Competing Interests: Declaration of competing interest None.
- Published
- 2024
- Full Text
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4. Influence of household pet ownership and filaggrin loss-of-function mutations on eczema prevalence in children: A birth cohort study.
- Author
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Toyokuni K, Yamamoto-Hanada K, Yang L, Hagino K, Harama D, Omori M, Matsumoto Y, Suzuki D, Umezawa K, Takada K, Shimada M, Hirai S, Ishikawa F, Hamaguchi S, Saito-Abe M, Sato M, Miyaji Y, Kabashima S, Fukuie T, Noguchi E, Suzuki K, and Ohya Y
- Subjects
- Humans, Male, Female, Animals, Prevalence, Infant, Child, Preschool, Intermediate Filament Proteins genetics, Loss of Function Mutation, Birth Cohort, Infant, Newborn, Cats, Cohort Studies, Ownership, Japan epidemiology, Dogs, Family Characteristics, Filaggrin Proteins, Pets, Eczema epidemiology, Eczema genetics
- Abstract
Background: The association between pet exposure in infancy, early childhood eczema, and FLG mutations remains unclear., Methods: This was a birth cohort study performed in Tokyo, Japan. The primary outcome was current eczema based on questionnaire responses collected repeatedly from birth to 5 years of age. Generalized estimating equations and generalized linear modeling were used to evaluate the association., Results: Data from 1448 participants were used for analyses. Household dog ownership during gestation, early infancy, and 18 months of age significantly reduced the risk of current eczema. Household cat ownership also reduced the risk of current eczema, albeit without statistical significance. The combined evaluation of children from households with pets, be it cats, dogs or both, the risk of current eczema at 1-5 years of age was lower in those with household pet exposure ownership during gestation (RR = 0.59, 95 % CI 0.45-0.77) and at 6 months (RR = 0.49, 95 % CI 0.36-0.68). , Reduced risks of eczema were also observed at 2-5 (RR = 0.52, 95 % CI 0.37-0.73) and 3-5 years of age (RR = 0.50 95 % CI 0.35-0.74) when the respective household pet ownership were evaluated at 18 months and 3 years of age. These protective associations of reduced risk of eczema were only observed in children without FLG mutations., Conclusions: Household dog and pet (dog, cat, or both) ownership was protective against early childhood eczema in a birth cohort dataset. This protective association was observed only in children without FLG mutations, which should be confirmed in studies with larger cohorts., (Copyright © 2024 Japanese Society of Allergology. Published by Elsevier B.V. All rights reserved.)
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- 2024
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5. Role of inflammatory markers in the assessment of meningitis in adult patients with fever and headache.
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Takada T, Yoshida K, Hamaguchi S, and Fukuhara S
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- Humans, Male, Female, Retrospective Studies, Middle Aged, Adult, Aged, Diagnosis, Differential, C-Reactive Protein analysis, Headache blood, Headache diagnosis, Biomarkers blood, Meningitis, Bacterial diagnosis, Meningitis, Bacterial blood, Fever blood, Fever diagnosis, Meningitis, Aseptic diagnosis, Meningitis, Aseptic blood
- Abstract
Background: Meningitis, especially of bacterial origin, is a medical emergency that must be diagnosed promptly. However, due to the associated risks of complications of lumbar puncture, it is crucial to identify individuals who truly need it. The aim of this study was to assess the diagnostic role of inflammatory markers in distinguishing among patients without meningitis, those with aseptic meningitis, and those with bacterial meningitis., Methods: This was a retrospective, diagnostic study at an acute care hospital, involving adult patients who presented to either ambulatory care or the emergency department with fever and headache, but without altered mental status or neurological deficits. Inflammatory markers (C-reactive protein [CRP], mean platelet volume, neutrophil-lymphocyte ratio, and red cell distribution width) were assessed as index tests. An expert panel classified patients into three groups: no meningitis, aseptic meningitis, and bacterial meningitis using predefined criteria., Results: Of the 80 patients, 52 had no meningitis, 27 had aseptic meningitis, and 1 had bacterial meningitis. Of the inflammatory markers investigated, only CRP showed potential usefulness in differentiating these three diagnostic groups, with median values of 5.6 (interquartile range [IQR] 2.1, 11.3) mg/dL in those without meningitis, 0.2 (IQR 0.1, 1.2) mg/dL in those with aseptic meningitis, and notably elevated at 21.7 mg/dL in the patient with bacterial meningitis., Conclusion: In adult patients presenting with fever and headache in an emergency setting, CRP was the only marker that demonstrated potential diagnostic utility in distinguishing among those with no meningitis, aseptic meningitis, and bacterial meningitis., (Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.)
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- 2024
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6. Characteristics of food protein-induced enterocolitis syndrome with metabolic acidosis: A case-control study.
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Hamaguchi S, Yamamoto-Hanada K, Ogawa E, Uematsu S, Ohnishi S, Ito Y, Toyokuni K, Sato M, Fukuie T, Ohya Y, and Nomura I
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- 2024
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7. Successful diagnosis of a localized liver tumor via transjugular liver biopsy after ascites hampered a percutaneous approach.
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Hamaguchi S, Nakashima Y, Dote M, Wada S, Hashimoto K, and Mimura H
- Abstract
Liver biopsy is a crucial diagnostic procedure for liver-related conditions. However, it is challenging to use in cases with substantial ascites or coagulopathy. Transjugular liver biopsy has been introduced as an alternative method to overcome these limitations. Although transjugular liver biopsy is commonly used for diffuse liver diseases, its application to localized tumors has been limited. We report the case of a 66-year-old male initially diagnosed with unresectable pancreatic carcinoma, who later developed liver metastasis, peritoneal dissemination, and ascites. Treatment planning required tumor re-evaluation, but percutaneous liver biopsy was not viable because of the rapid accumulation of ascites and its presence on the liver surface. However, transjugular liver biopsy was a suitable alternative, given the proximity of the tumor to the right hepatic vein. The procedure, performed under fluoroscopic and ultrasound guidance, successfully obtained 4 specimens that were promptly diagnosed as liver metastases originating from pancreatic cancer. This case underscored the effectiveness of transjugular liver biopsy in situations where percutaneous biopsy is challenging because of conditions such as ascites. The combination of ultrasound guidance and rapid specimen assessment by pathology technicians can enhance diagnostic success rates. Transjugular liver biopsy is a valuable diagnostic tool in scenarios where percutaneous access poses significant difficulties., (© 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2023
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8. The Japanese Epidemiologic Study for Perioperative Anaphylaxis, a prospective nationwide study: clinical signs, severity, and therapeutic agents.
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Sugiyama Y, Takazawa T, Watanabe N, Bito K, Fujiyoshi T, Hamaguchi S, Haraguchi T, Horiuchi T, Kamiya Y, Maruyama N, Masumo H, Nakazawa H, Nagumo K, Orihara M, Sato J, Sekimoto K, Takahashi K, Uchiyama M, Takahashi K, Yamaguchi M, and Kawamata M
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- Humans, Adrenal Cortex Hormones therapeutic use, East Asian People, Epinephrine therapeutic use, Prospective Studies, Anaphylaxis diagnosis, Anaphylaxis drug therapy, Anaphylaxis epidemiology, Anesthesia adverse effects
- Abstract
Background: Diagnosis of perioperative anaphylaxis is difficult because of its non-specific and variable signs and symptoms. Therapeutic agents used to treat anaphylaxis and anaesthesiologist responses also vary depending on the case, which might affect outcomes; however, only a few studies have focused on these factors., Methods: This prospective study of perioperative anaphylaxis, a part of the Japanese Epidemiologic Study for Perioperative Anaphylaxis, investigated the clinical signs, its severity, therapeutic drugs, epinephrine administration, and anaesthesiologist responses in cases of perioperative anaphylaxis to assess trends and variability. Shock index was used to assess severity of cardiovascular collapse., Results: In 43 patients analysed in this study, cardiovascular signs (88.4%) were the most frequent, followed by skin (81.4%) and respiratory signs (60.5%). The presence of signs increased during the clinical course. The median time from the first signs to diagnosis of anaphylaxis was 10 (5.0-17.8) min. The rates of epinephrine use were 30.2% (unused), 48.8% (i.v.), and 20.9% (i.m.). The median time from diagnosis of anaphylaxis to epinephrine administration was 7 (inter-quartile range: 1.5-8.0) min. Antihistamines and corticosteroids were each used in 69.8% of cases. The worst shock index was higher in patients who received i.v. epinephrine (2.77 [0.90] mean [standard deviation]) than in both no epinephrine use cases (1.35 [0.41]) and i.m. epinephrine cases (1.89 [0.77] (P<0.001])., Conclusions: The clinical signs and treatments of perioperative anaphylaxis are variable, and the choice regarding epinephrine administration is based on symptom severity., Clinical Trial Registration: UMIN000035350., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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9. Ruptured Baker's cyst.
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Nakagawa H and Hamaguchi S
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- Humans, Diagnosis, Differential, Popliteal Cyst diagnostic imaging, Osteoarthritis, Knee
- Abstract
Competing Interests: Declaration of Competing Interest None.
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- 2023
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10. Serological cross-reactivity between spotted fever and typhus groups of rickettsia infection in Japan.
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Aita T, Sando E, Katoh S, Hamaguchi S, Fujita H, and Kurita N
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- Animals, Mice, Humans, Japan, Rickettsia typhi, Serologic Tests, Immunoglobulin M, Immunoglobulin G, Antibodies, Bacterial, Typhus, Epidemic Louse-Borne, Rickettsia Infections diagnosis, Spotted Fever Group Rickettsiosis diagnosis, Rickettsia, Typhus, Endemic Flea-Borne diagnosis, Typhus, Endemic Flea-Borne epidemiology
- Abstract
Objectives: We examined the frequency of cross-reactions to Rickettsia typhi in patients with Japanese spotted fever (JSF) and evaluated the differences between two rickettsiae using antibody endpoint titers., Methods: Patients' immunoglobulin (Ig)M and IgG titers against Rickettsia japonica and Rickettsia typhi in two phases were measured using an indirect immunoperoxidase assay at two reference centers for rickettsiosis in Japan. Cross-reaction was defined as a higher titer against R. typhi in convalescent sera than in acute sera among patients fulfilling the criteria for JSF diagnosis. The frequencies of IgM and IgG were also evaluated., Results: Approximately 20% of cases showed positive cross-reactions. A comparison of antibody titers revealed the difficulty in identifying some positive cases., Conclusion: Cross-reactions of 20% in serodiagnosis may lead to the misclassification of rickettsial diseases. However, with the exception of some cases, we were able to successfully differentiate JSF from murine typhus using each endpoint titer., Competing Interests: Declaration of competing interest The authors have no conflict of interest to declare., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
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11. Morning facial rash: A clue to night epileptic seizure.
- Author
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Nakagawa H and Hamaguchi S
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- Humans, Seizures diagnosis, Seizures etiology, Epilepsy
- Abstract
Competing Interests: Declaration of Competing Interest None.
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- 2023
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12. Safety evaluation of MA-T after ingestion in mice.
- Author
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Noguchi T, Tachibana K, Inoue T, Sakai T, Tsujikawa K, Fujio Y, Yamagishi Y, Hamaguchi S, Kutsuna S, and Kondoh M
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- Animals, Body Weight, Eating, Mice, Mouthwashes toxicity, COVID-19, Disinfectants toxicity, Drinking Water
- Abstract
MA-T (Matching Transformation System®) is a proprietary chemical mixture for on-demand production of aqueous chlorine dioxide that is used for the treatment of oral malodor. MA-T is also an effective disinfectant against at least 39 pathological microorganisms, including severe acute respiratory syndrome coronavirus 2, and therefore may be useful as a disinfectant mouthwash to prevent the spread of infection. Accidental ingestion is the putative worst hazard scenario associated with mouthwash use; therefore, here we investigated the safety of MA-T ingestion in mice. Mice were provided drinking water containing 0-3000 μg/ml MA-T for 7 days followed by non-spiked drinking water for an additional 14 days. At day 7, mice ingesting 1000 or 3000 μg/ml MA-T showed significantly decreased body weight and significantly increased liver, kidney, and heart tissue injury biomarkers compared with control. However, at 14 days after stopping MA-T ingestion, body weight and tissue injury biomarkers had returned to normal. Histological analysis revealed that MA-T-induced injuries in liver, kidney, spleen, stomach, duodenum, colon, and rectum had also recovered at 14 days after stopping MA-T ingestion; however, mild vascular endothelial injuries remained in heart, jejunum, and ileum in the worst-case scenario. Taken together, MA-T may be potentially safety for further development as a disinfectant mouthwash by risk management, such as placing a caution of the label and adding a distinctive flavor., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
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13. Successful treatment of chylous ascites by superselective embolization of the inflowing lymphatic vessels using a steerable microcatheter: a case study.
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Hamaguchi S, Michigami Y, Inoue M, Tsukamoto K, Wada S, and Ogawa Y
- Abstract
Background: Chylous ascites resulting from postoperative lymphatic leaks are uncommon but difficult to treat in cases with unsuccessful conservative treatment., Case Report: We report the case of an 80-year-old woman who had previously undergone multiple procedures for peritoneal dissemination 3.5 months after a laparoscopic bilateral salpingo-oophorectomy for ovarian cancer. After hospital discharge, she gradually gained weight, and examination findings indicated lymphatic leakage. We performed drainage using an 8.5-French Dawson-Mueller catheter, but more aggressive treatment was deemed necessary. We determined that it would be difficult to fill the large space, in which the leaking lymph fluid was accumulating, with embolic materials. Therefore, we performed superselective embolization of these inflowing lymphatic vessels to allow control of the chylous ascites. To overcome the technical difficulty associated with the insertion of a microcatheter from a large leakage cavity into a small inflow lymphatic vessel, we adopted a triple coaxial system that utilizes a steerable microcatheter. Successful embolization resulted in marked decrease in drainage. Follow-up computed tomography revealed no evidence of reaccumulation of chylous ascites. A three-month follow-up revealed no recurrence of lymphatic leakage., Conclusions: To our knowledge, this is the first report on the treatment of large retropenitoneal chylous leakage by superselective embolization of the inflowing lymphatic vessels using steerable microcatheters. This method allows large lymphatic leaks to be treated with only a small amount of N-butyl 2-cyanoacrylate mixture and without the use of coils, and we firmly believe that it should be considered for the treatment of large refractory chylous ascites., (© 2022 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
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- 2022
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14. Results of 10-year mobile low-dose computed tomography screenings for lung cancer in Shimane, Japan.
- Author
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Hamaguchi M, Tsubata Y, Tanino A, Mitarai Y, Hata K, Kobayashi M, Shiratsuki Y, Okuno T, Nakao M, Amano Y, Nakashima K, Hotta T, Hamaguchi S, Nagao T, Kurimoto N, and Isobe T
- Subjects
- Adult, Humans, Japan epidemiology, Mass Screening, Retrospective Studies, Tomography, X-Ray Computed, Early Detection of Cancer, Lung Neoplasms diagnostic imaging, Lung Neoplasms epidemiology
- Abstract
Background: Some randomized controlled trials have evaluated the effects of low-dose computed tomography (CT) screening on lung cancer mortality in heavy smokers. Based on the results of those trials, our CT screening program recommended screening for people aged ≥40 years with a history of smoking. This retrospective study aimed to verify the validity of our CT screening program and elucidate the current state of CT screening program., Methods: We retrospectively examined lung cancer detection in 25,189 participants who underwent chest CT screening by a mobile low-dose CT screening unit in the 10-year period from April 2009 to March 2019. Participants were recruited at Japan Agricultural Cooperatives (JA) Shimane Kouseiren. Participants requested CT screening for lung cancer. CT images were read by two pulmonologists., Results: Lung cancer was identified in 82 of the 25,189 participants over 10 years, an overall lung cancer detection rate (percentage of lung cancers detected among all participants) of 0.33%. Lung cancer among never smokers accounted for 54.9% of the detected cases. The lung cancer detection rate was similar for smokers versus never smokers. The stage IA detection rate (percentage of stage IA lung cancers among all lung cancers detected) was 62%, while the stage Ⅳ detection rate was 10%., Conclusions: Chest CT detected lung cancer in never smokers as well as current or former smokers. Our CT screening program was not effective for never smokers; thus, further study of the effectiveness of CT screening in never smokers is needed., Competing Interests: Conflict of Interest The authors declare no conflict of interest., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2022
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15. 10-Year survey on serum antibody positivity rates and titers for measles and rubella in healthcare workers; an observational study at a Japanese university hospital.
- Author
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Yoshioka N, Deguchi M, Hagiya H, Kagita M, Tsukamoto H, Takao M, Yoshida H, Hamaguchi S, Maeda I, Hidaka Y, and Tomono K
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- Antibodies, Viral, Germany, Health Personnel, Hospitals, University, Humans, Japan epidemiology, Measles-Mumps-Rubella Vaccine, Vaccination, Measles epidemiology, Measles prevention & control, Mumps, Rubella prevention & control
- Abstract
Background: We evaluated the effect of the two-dose vaccination strategy, which has been a widely adopted as childhood routine schedule worldwide to acquire herd immunity, on healthcare workers (HCWs) in Japan., Methods: Between 2010 and 2019, antibody titers for measles and rubella were measured annually among newly employed HCWs at Osaka University Hospital, Japan, using Enzygnost® assays (Siemens Healthcare Diagnostics Co. Ltd., Marburg, Germany). The data were categorized by age to compare the antibody positivity rates and antibody titers among no-vaccine, single-dose, and two-dose groups., Results: Over the 10-year period, the annual antibody positivity rates for measles and rubella were 84.0%-95.3% and 90.0%-94.5%, respectively, without any particular trend. The antibody titers for measles (median [interquartile range]: 8.4 [3.9, 20] vs. 6.1 [3.5, 12]) and rubella (11 [5.5, 20] vs. 6 [3.7, 11]) were statistically lower (p < 0.001) in the two-dose generation than in the single-dose generation., Discussion: A shift from single-dose to two-dose vaccination did not yield an increase in antibody positivity rates for both measles and rubella among HCWs. Notably, antibody titers were significantly lower in the two-dose generation., Conclusion: Despite several limitations, our data suggests a paradoxical vulnerability in young HCWs who received the two-dose vaccination in a view of sero-positivity rates., (Copyright © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2021
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16. Preloading Coil in Plug Method (p-CIP) with the AVP 2 for large Portosystemic Shunt Embolization.
- Author
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Hashimoto K, Ogawa Y, Wada S, Kobayashi D, Hamaguchi S, Moriya J, and Mimura H
- Abstract
Hepatic encephalopathy caused by a large portosystemic shunt (PSS) can be treated by endovascular embolization of the shunt. The PSS diameter can be >20 mm; it occasionally poses technical difficulties. Here, a 72-year-old woman with liver cirrhosis, hyperammonemia, and large spleno-renal shunt underwent shunt embolization using an Amplatzer vascular plug 2 (AVP2) and metallic coils. The preloading coil in plug method (p-CIP), which facilitated embolization inside the AVP2 without cannulation from outside, was employed to overcome technical difficulties. We propose the use of p-CIP with an AVP2 as a tool for treatment of hepatic encephalopathy with PSS., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
- Published
- 2021
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17. The characteristics and clinical course of patients with COVID-19 who received invasive mechanical ventilation in Osaka, Japan.
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Hirayama A, Masui J, Murayama A, Fujita S, Okamoto J, Tanaka J, Hirayama T, Ohara T, Hoffmann EN, Zhang J, Kawachi H, Okuno H, Hamaguchi S, Tomono K, and Asada R
- Subjects
- Adult, Aged, Aged, 80 and over, COVID-19 mortality, Female, Humans, Logistic Models, Male, Middle Aged, Retrospective Studies, COVID-19 therapy, Respiration, Artificial methods, SARS-CoV-2
- Abstract
Objective: To describe the detailed clinical course of patients with coronavirus disease 2019 (COVID-19) who received invasive mechanical ventilation., Methods: We conducted a case series of patients with COVID-19 who received invasive mechanical ventilation in Osaka, Japan, between January 29 and May 28, 2020. We describe the patient characteristics and clinical course from onset. Additionally, we fitted logistic regression models to investigate the associations between patient characteristics and the 30-day mortality rate., Results: A total of 125 patients who received invasive mechanical ventilation (median age [interquartile range], 68 [57-73] years; male, 77.6%) were enrolled. Overall, the 30-day mortality was 24.0%, and the median (interquartile range) length of ICU stay and length of invasive mechanical ventilation use were 16 (12-29) days and 13 (9-26) days, respectively. From clinical onset, 121 patients (96.8%) were intubated within 14 days. In multivariable logistic regression analysis, age of 65 years or older (odds ratio, 3.56; 95% confidence interval, 1.21-10.49; P = 0.02) and male sex (odds ratio, 3.75; 95% confidence interval, 1.00-11.24, P = 0.04) were significantly associated with a higher 30-day mortality rate., Conclusions: In this case series of patients with COVID-19 who received invasive mechanical ventilation in Japan, the 30-day mortality rate was 24.0%, and age 65 years or older and male sex were associated with higher 30-day mortality rate., (Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2021
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18. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of japanese society of chemotherapy, the japanese association for infectious diseases, and the japanese society for clinical microbiology in 2016: General view of the pathogens' antibacterial susceptibility.
- Author
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Yanagihara K, Matsumoto T, Tokimatsu I, Tsukada H, Fujikura Y, Miki M, Morinaga Y, Sato J, Wakamura T, Kiyota H, Tateda K, Hanaki H, Fujiuchi S, Takahashi M, Kayaba H, Mori Y, Takeda H, Ikeda H, Takahashi H, Konno M, Niitsuma K, Niki Y, Takuma T, Kawana A, Kudo M, Hirano T, Miyazawa N, Aso S, Aoki N, Honma Y, Yamamoto Y, Iinuma Y, Mikamo H, Yamagishi Y, Nakamura A, Kondo S, Kawabata A, Sugaki Y, Yamamoto T, Nishi I, Hamaguchi S, Kakeya H, Fujikawa Y, Mitsuno N, Ukimura A, Yoshida K, Hayashi M, Mikasa K, Kasahara K, Tokuyasu H, Hino S, Shimizu E, Chikumi H, Fujita M, Kadota J, Hiramatsu K, Suga M, and Muranaka H
- Subjects
- Adult, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Drug Resistance, Bacterial, Haemophilus influenzae, Humans, Japan epidemiology, Microbial Sensitivity Tests, Communicable Diseases drug therapy, Methicillin-Resistant Staphylococcus aureus, Respiratory Tract Infections drug therapy, Respiratory Tract Infections epidemiology
- Abstract
The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2016. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between February 2016 and August 2016 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standards Institute. Susceptibility testing was evaluated in 1062 strains (143 Staphylococcus aureus, 210 Streptococcus pneumoniae, 17 Streptococcus pyogenes, 248 Haemophilus influenzae, 151 Moraxella catarrhalis, 134 Klebsiella pneumoniae, and 159 Pseudomonas aeruginosa). Ratio of methicillin-resistant S. aureus was 48.3%, and those of penicillin-susceptible S. pneumoniae was 99.5%. Among H. influenzae, 14.1% of them were found to be β-lactamase-producing ampicillin-resistant strains, and 41.1% to be β-lactamase-non-producing ampicillin-resistant strains. Extended spectrum β-lactamase-producing K. pneumoniae and multi-drug resistant P. aeruginosa with metallo β-lactamase were 4.5% and 0.6%, respectively., Competing Interests: Declaration of competing interest Katsunori Yanagihara received speaker honoraria from Taisho Toyama Pharmaceutical Co., Ltd., Pfizer Japan Inc., MSD K.K., Astellas Pharma Inc., Daiichi Sankyo Co., Ltd., Nippon Becton Dickinson Company, Ltd., and bioMerieux Japan Ltd., and received scholarship donations from Toyama Chemical Co., Ltd., Sumitomo Dainippon Pharma Co., Ltd., Daiichi Sankyo Co., Ltd., Pfizer Japan Inc., MSD K.K., Taiho Pharmaceutical Co., Ltd., and FUJIFILM Toyama Chemical Co., Ltd. and received research funds from Nippon Becton Dickinson Company, Ltd., Shionogi, Kyorin Pharmaceutical Co., Ltd., Tosoh Corporation, Miyarisan Pharmaceutical Co., Ltd., and FUJIFILM Toyama Chemical Co., Ltd. Tetsuya Matsumoto received speaker honoraria from MSD K·K., and Pfizer Japan Inc. Makoto Miki received speaker honoraria from Kyorin Pharmaceutical Co., Ltd. Yoshitomo Morinaga received research funds from Nippon Becton Dickinson Company, Ltd., Shionogi & Co., Ltd., Kyorin Pharmaceutical Co., Ltd., Tosoh Corporation, Miyarisan Pharmaceutical Co., Ltd., Roche Diagnostics K·K., Beckman Coulter Inc., Parexel International Co., Ltd., and FUJIFILM Toyama Chemical Co., Ltd. Issei Tokimatsu received scholarship donations from Astellas Pharma Inc., Daiichi Sankyo Co., Ltd., and Shionogi & Co., Ltd. Hiroshi Kiyota have received scholarship donations from Taisho Toyama Pharmaceutical Co., Ltd., Toyama Chemical Co., Ltd., Daiichi Sankyo Co., Ltd., Astellas Pharma Inc., Taiho Pharmaceutical Co., Ltd., and Sanofi K·K. Yoshihito Niki received speaker honoraria from Pfizer Japan Inc., MSD K·K., Astellas Pharma Inc., Taisho Toyama Pharmaceutical Co., Ltd., MSD K·K., Sumitomo Dainippon Pharma Co., Ltd., and Asahi Kasei Pharma Corporation, and received scholarship donations from Astellas Pharma Inc., Daiichi Sankyo Co., Ltd., Taiho Pharmaceutical Co., Ltd., MSD K·K., and Shionogi & Co., Ltd. Takahiro Takuma received scholarship donations from Astellas Pharma Inc., Daiichi Sankyo Co., Ltd., and Shionogi & Co., Ltd. Nobuki Aoki received speaker honoraria from Kyorin Pharmaceutical Co., Ltd. Yoshihiro Yamamoto received research fund from Pfizer Japan Inc. Yoshitsugu Iinuma received speaker honoraria from MSD K·K. Atsushi Nakamura received speaker honoraria from MSD K·K., Kyorin Pharmaceutical Co., Ltd., and Astellas Pharma Inc. Hiroshi Kakeya received speaker honoraria from MSD K·K., Pfizer Japan Inc., Sumitomo Dainippon Pharma Co., Ltd., and Astellas Pharma Inc. Koichiro Yoshida received speaker honoraria from MSD K·K. Junichi Kadota received speaker honoraria from MSD K·K., Nippon Boehringer Ingelheim Co., Ltd., and Astrazeneca Co., Ltd., and received research funds from Taisho Toyama Pharmaceutical Co., Ltd., MSD K·K., and Nippon Boehringer Ingelheim Co., Ltd., and received scholarship donation from Daiichi Sankyo Co., Ltd., (Copyright © 2020. Published by Elsevier Ltd.)
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- 2020
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19. Endovascular retrieval of a Gunther-tulip vena cava filter migrated into the right atrium.
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Yamada T, Shinjo Y, Yagihashi K, Hashimoto K, and Hamaguchi S
- Abstract
A 72-year-old male underwent placement of a Gunther-tulip vena cava filter to prevent development of a pulmonary embolism. One month later, when we tried to retrieve the Gunther-tulip vena cava filter via a transjugular approach, the filter detached from the snare and became free in the outer sheath. The Gunther-tulip vena cava filter did not reopen in the inferior vena cava probably because it became entangled with a thrombus; rather, the filter migrated into the right atrium. The filter orientation rendered the transjugular approach inappropriate; we used a bilateral transfemoral approach to aid filter retrieval. It is necessary to be very cautious when reopening a filter that has closed within the sheath. Although the filter migrated into the heart, we retrieved it using a combined approach., (© 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
- Published
- 2020
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20. Comparison of the chest computed tomography findings between patients with pulmonary tuberculosis and those with Mycobacterium avium complex lung disease.
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Miura K, Nakamura M, Taooka Y, Hotta T, Hamaguchi M, Okimoto T, Tsubata Y, Hamaguchi S, Kuraki T, and Isobe T
- Subjects
- Humans, Mycobacterium avium Complex, Mycobacterium avium-intracellulare Infection, Pneumonia, Bacterial diagnostic imaging, Pneumonia, Bacterial microbiology, Radiography, Thoracic, Tomography, X-Ray Computed, Tuberculosis, Pulmonary diagnostic imaging
- Abstract
Background: Since the computed tomography (CT) findings of nontuberculous mycobacterial lung disease are similar to those of pulmonary tuberculosis (PTB), we often have difficulty differentiating the two. In this study, we compared the differences in chest CT findings and their locations between cases of PTB and Mycobacterium avium complex lung disease (MACLD)., Methods: The subjects were 100 MACLD patients and 42 PTB patients treated at our hospital from May 2005 to August 2015. The CT findings were retrospectively evaluated., Results: PTB more frequently showed lung shadows with calcification inside the lesion, calcification of the mediastinal/hilar lymph node, and pleural effusion on CT than MACLD, while extensive bronchiectasis and granular/large shadows connected to bronchiectasis were more frequently observed with MACLD than PTB. For cavitary lesions, the thinnest part of the cavity wall with MACLD was thinner than that with PTB. Granular shadows, large shadows, and bronchiectasis were typically distributed to the right upper lobe and left upper division in PTB cases vs. the right intermediate lobe and left lingula in MACLD., Conclusions: Chest CT findings would therefore be useful for distinguishing PTB and MACLD when typical findings are observed., Competing Interests: Declaration of Competing Interest Yukari Tsubata received personal fees from AstraZeneca, Chugai Pharmaceutical and Daiichi-Sankyo, outside of the submitted work. Takeshi Isobe received personal fees from AstraZeneca, Pfizer and Boehringer Ingelheim, outside of the submitted work. The remaining authors declare no conflict of interest., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2020
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21. Mycobacterium kansasii arthritis of the elbow in an immunocompetent patient with a suspected soft-tissue tumor.
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Okuno H, Tanaka H, Hagiya H, Yoshida H, Hamaguchi S, Hori Y, Morii E, Hamada K, Yoshikawa H, and Tomono K
- Subjects
- Aged, Anti-Bacterial Agents therapeutic use, Arthritis, Infectious complications, Arthritis, Infectious drug therapy, Clarithromycin therapeutic use, Diagnosis, Differential, Elbow Joint diagnostic imaging, Ethambutol therapeutic use, Humans, Immunocompetence, Magnetic Resonance Imaging, Male, Mycobacterium Infections, Nontuberculous complications, Mycobacterium Infections, Nontuberculous drug therapy, Rifampin therapeutic use, Treatment Outcome, Arthritis, Infectious diagnosis, Elbow Joint pathology, Mycobacterium Infections, Nontuberculous diagnosis, Mycobacterium kansasii isolation & purification, Soft Tissue Neoplasms diagnosis
- Abstract
Mycobacterium kansasii is one of the major non-tuberculous mycobacteria species that typically cause pulmonary diseases. M. kansasii is known to cause septic arthritis as an extrapulmonary disease in immunosuppressed patients or chronic skin disease. Herein, we present a case of M. kansasii arthritis involving the elbow of an immunocompetent patient, which was initially suspected to be a soft-tissue tumor. A 70-year-old man presented with a swollen left elbow that had progressed for 18 months with deteriorating arthralgia and limited range of motion. Magnetic resonance imaging revealed filling of the intra-articular space of the elbow and surrounding of the radial head with a soft tissue mass with mixed signal intensity. Initial incisional biopsy was performed via the lateral approach to the elbow joint, and pathological examination of the mass did not reveal any evidence of malignancy. One year after the first operation, arthroscopic surgery was performed to excise the mass following the recurrence of swelling and limited function of the elbow. Pathological examination of the resected synovium revealed epithelioid granulomas containing a multinucleated giant cell and inflammatory cell infiltration, characteristic of mycobacterial infection. M. kansasii was cultured after 2 weeks of incubation of the synovial sample. He experienced full resolution of the swelling and limited function following a combination of synovectomy and multidrug antimycobacterial treatment (rifampin 600 mg/day, clarithromycin 800 mg/day, and ethambutol 750 mg/day). This case highlights the need to consider this rare infection in the differential diagnosis of intra-articular soft tissue tumor-like lesions even in immunocompetent patients., (Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
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22. New procedure of bronchoalveolar lavage using a balloon catheter in diffuse lung diseases.
- Author
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Hotta T, Kurimoto N, Okimoto T, Tsubata Y, Hamaguchi S, and Isobe T
- Subjects
- Humans, Bronchoalveolar Lavage methods, Lung Diseases therapy
- Abstract
Background: Various procedures for bronchoalveolar lavage (BAL) have been developed. BAL needs a wedge between the bronchoscope and the inner surface of the bronchus. The feasibility of performing BAL at the targeted position cannot be determined until immediately before the procedure. We examined BAL performed using a balloon catheter to evaluate the stability of the procedure itself and quality of the specimen obtained., Methods: The main inclusion criteria were diffuse lung disease with a shadow in the B
5 a area. The tip of a disposable balloon catheter was passed through the orifice of the B5 a bronchus, and the balloon was expanded at the B5 a bronchus. A 50-mL syringe containing saline was instilled, and gentle hand suction was performed. This procedure was repeated two more times (total: 150 mL)., Results: In all the 13 patients, the balloon of the catheter was inflated at the B5 a bronchus. The median recovery rate was 34.92% ± 13.22%. These values were comparable to previously obtained BAL data (control group, N = 56) from our facility. The BAL fluid findings and final diagnosis, with the exception of one undiagnosed case, were consistent. Overall, four patients suffered an adverse event during BAL (hypoxemia). All cases were managed by increasing the oxygen flow rate, and the adverse event did not affect the subsequent examinations., Conclusions: Using a balloon catheter enabled us to perform BAL at the intended bronchus. The quality of the obtained specimen was also acceptable., (Copyright © 2019 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)- Published
- 2020
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23. Bacteremia due to high-level daptomycin-resistant Corynebacterium striatum: A case report with genetic investigation.
- Author
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Hagiya H, Kimura K, Okuno H, Hamaguchi S, Morii D, Yoshida H, Mitsui T, Nishi I, and Tomono K
- Subjects
- Aged, Anti-Bacterial Agents therapeutic use, Bacteremia drug therapy, Corynebacterium drug effects, Corynebacterium Infections drug therapy, Daptomycin therapeutic use, Humans, Japan, Male, Bacteremia diagnosis, Bacteremia microbiology, Corynebacterium genetics, Corynebacterium Infections microbiology, Drug Resistance, Bacterial genetics
- Abstract
Corynebacterium striatum, generally considered an opportunistic organism in humans, has recently been known to develop high-level daptomycin resistance (HLDR) shortly after drug exposure. To date, however, only several such clinical isolates have been described in the literature and clinical background of the resistant pathogen remains to be elucidated. Here, we report a case involving a C. striatum strain with HLDR harboring novel nucleotide mutations, together with a review of the relevant literature. To the best of our knowledge, this is the first well-investigated clinical report from Japan including a genetic investigation. Considering the rapid emergence of HLDR C. striatum in vitro experiment, there could be a number of underreporting cases. Scrupulous attention is required when administering daptomycin for the treatment of C. striatum infections, even if the organism has initially exhibited susceptibility., (Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2019
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24. Simultaneous and rapid detection method for measles and rubella using single-tube multiplex real-time quantitative RT-PCR.
- Author
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Yoshioka N, Hagiya H, Deguchi M, Hamaguchi S, Kagita M, and Tomono K
- Subjects
- Disease Outbreaks prevention & control, Feasibility Studies, Humans, Japan epidemiology, Measles epidemiology, Measles virology, Morbillivirus genetics, Multiplex Polymerase Chain Reaction, RNA, Viral isolation & purification, Real-Time Polymerase Chain Reaction, Rubella epidemiology, Rubella virology, Rubella virus genetics, Sensitivity and Specificity, Time Factors, Measles diagnosis, Morbillivirus isolation & purification, Rubella diagnosis, Rubella virus isolation & purification
- Abstract
Patients with measles or rubella infections manifest acute onset fever accompanying systemic exanthema, which are clinically difficult to be distinguish. Rapid diagnosis and differentiation of such epidemic viral diseases is essential to prevent outbreaks. We developed a single-tube multiplex real-time PCR assay for these indistinguishable viruses. We used previously-reported primer settings, with a slight modification of reporter dye, and applied to multiplex Taqman real-time PCR by cobas z480 (Roche Molecular Systems, Inc.). Consequently, the assay could detect 10 copies/10 μl of measles and rubella with coefficient of variations of 11.2% and 21.8%, respectively. Strengths of our methodology include simplicity of operation, short measurement time (2 h), uses of internal control (confirming a run of PCR), and quantitative measurement with high sensitivity. Both measles and rubella currently cause social outbreaks in Japan. We hope that our single-tube multiplex assay contributes to an early diagnosis, leading to an appropriate infection control measure and prevention of epidemics., (Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2019
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25. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility.
- Author
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Yanagihara K, Matsumoto T, Aoki N, Sato J, Wakamura T, Kiyota H, Tateda K, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Akiba Y, Masunaga S, Takeuchi K, Takeda H, Miki M, Kumagai T, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Ishigaki S, Kobayasi N, Takasaki J, Mezaki K, Iwata S, Katouno Y, Inose R, Niki Y, Kawana A, Fujikura Y, Kudo M, Hirano T, Yamamoto M, Miyazawa N, Tsukada H, Aso S, Yamamoto Y, Iinuma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Kawabata A, Sugaki Y, Seki M, Hamaguchi S, Toyokawa M, Kakeya H, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Hayasi M, Mikasa K, Kasahara K, Koizumi A, Korohasi N, Matumoto T, Yosimura Y, Katanami Y, Takesue Y, Wada Y, Sugimoto K, Yamamoto T, Kuwabara M, Doi M, Simizu S, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Yatera K, Fujita M, Kadota J, Hiramatsu K, Aoki Y, Magarifuchi H, Oho M, Morinaga Y, Suga M, Muranaka H, Fujita J, Higa F, and Tateyama M
- Subjects
- Antimicrobial Stewardship, Haemophilus influenzae drug effects, Humans, Japan epidemiology, Klebsiella pneumoniae drug effects, Methicillin-Resistant Staphylococcus aureus drug effects, Microbial Sensitivity Tests, Moraxella catarrhalis drug effects, Pseudomonas aeruginosa drug effects, Respiratory Tract Infections microbiology, Streptococcus pneumoniae drug effects, Streptococcus pyogenes drug effects, Anti-Bacterial Agents therapeutic use, Drug Resistance, Bacterial, Epidemiological Monitoring, Respiratory Tract Infections prevention & control
- Abstract
The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2014. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between January 2014 and April 2015 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standards Institute. Susceptibility testing was evaluated in 1534 strains (335 Staphylococcus aureus, 264 Streptococcus pneumoniae, 29 Streptococcus pyogenes, 281 Haemophilus influenzae, 164 Moraxella catarrhalis, 207 Klebsiella pneumoniae, and 254 Pseudomonas aeruginosa). Ratio of methicillin-resistant S. aureus was 43.6%, and those of penicillin-susceptible S. pneumoniae was 100%. Among H. influenzae, 8.2% of them were found to be β-lactamase-producing ampicillin-resistant strains, and 49.1% to be β-lactamase-non-producing ampicillin-resistant strains. Extended spectrum β-lactamase-producing K. pneumoniae and multi-drug resistant P. aeruginosa with metallo β-lactamase were 9.2% and 0.4%, respectively., (Copyright © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2019
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26. Antibiotic-associated adverse drug events at a Japanese academic hospital.
- Author
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Kokado R, Hagiya H, Koyama T, Matsui E, Okuno H, Morii D, Hamaguchi S, Yoshida H, Miwa Y, and Tomono K
- Subjects
- Hospitals, Teaching, Humans, Incidence, Japan epidemiology, Retrospective Studies, Adverse Drug Reaction Reporting Systems statistics & numerical data, Anti-Bacterial Agents adverse effects, Antimicrobial Stewardship statistics & numerical data, Drug-Related Side Effects and Adverse Reactions epidemiology, Hospitals statistics & numerical data
- Abstract
Introduction: To promote antimicrobial stewardship activity, an understanding of the incidence of antibiotic-associated adverse drug events (ADEs) is essential. In this study, we aimed to describe the occurrence of antibiotic-associated ADEs at our hospital., Methods: We retrospectively searched the ADE registration system in Osaka University Hospital between 2010 and 2017. Registrations of ADEs were dependent on the patients' drug history and clinical course after hospitalization. We classified the data according to types of ADEs (gastrointestinal, hepatobiliary, renal, cardiac, respiratory, hematologic, neurologic, dermatologic, and musculoskeletal) and antibiotic class., Results: During the study period, we found 707 cases of antibiotic-associated ADEs, accounting for 22.3% of all the cases. Beta-lactam antibiotics constitute more than half of the cases (51.3%). The most common ADE was dermatologic abnormalities (53.4%), followed by liver dysfunction (9.7%) and gastrointestinal symptoms (8.9%). Among all antibiotics, oral third-generation cephalosporins were frequently reported as offending drugs (107 cases), accounting for 29.5% of beta-lactam ADEs and 46.3% of cephem ADEs., Conclusion: Antibiotic-associated ADEs covered approximately 20% of all the ADEs at our hospital. We believe that the data would be helpful in ensuring patient safety by promoting antimicrobial stewardship in hospitals., (Copyright © 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2019
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27. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility.
- Author
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Yanagihara K, Watanabe A, Aoki N, Matsumoto T, Yoshida M, Sato J, Wakamura T, Sunakawa K, Kadota J, Kiyota H, Iwata S, Kaku M, Hanaki H, Ohsaki Y, Fujiuchi S, Takahashi M, Takeuchi K, Takeda H, Ikeda H, Miki M, Nakanowatari S, Takahashi H, Utagawa M, Nishiya H, Kawakami S, Morino E, Takasaki J, Mezaki K, Chonabayashi N, Tanaka C, Sugiura H, Goto H, Saraya T, Kurai D, Katono Y, Inose R, Niki Y, Takuma T, Kudo M, Ehara S, Sato Y, Tsukada H, Watabe N, Honma Y, Mikamo H, Yamagishi Y, Nakamura A, Ohashi M, Seki M, Hamaguchi S, Toyokawa M, Fujikawa Y, Mitsuno N, Ukimura A, Miyara T, Nakamura T, Mikasa K, Kasahara K, Ui K, Fukuda S, Nakamura A, Morimura M, Yamashita M, Takesue Y, Wada Y, Sugimoto K, Kusano N, Nose M, Mihara E, Kuwabara M, Doi M, Watanabe Y, Tokuyasu H, Hino S, Negayama K, Mukae H, Kawanami T, Ota T, Fujita M, Honda J, Hiramatsu K, Aoki Y, Fukuoka M, Magarifuchi H, Nagasawa Z, Kaku N, Fujita J, Higa F, and Tateyama M
- Subjects
- Drug Resistance, Bacterial, Haemophilus influenzae drug effects, Haemophilus influenzae isolation & purification, Humans, Japan, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae isolation & purification, Microbial Sensitivity Tests, Moraxella catarrhalis drug effects, Moraxella catarrhalis isolation & purification, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa isolation & purification, Public Health Surveillance, Staphylococcus aureus drug effects, Staphylococcus aureus isolation & purification, Streptococcus pneumoniae drug effects, Streptococcus pneumoniae isolation & purification, Streptococcus pyogenes drug effects, Streptococcus pyogenes isolation & purification, beta-Lactamases analysis, Anti-Bacterial Agents pharmacology, Bacteria drug effects, Bacteria isolation & purification, Respiratory System microbiology, Respiratory Tract Infections microbiology
- Abstract
The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by Japanese Society of Chemotherapy, Japanese association for infectious diseases and Japanese society for Clinical Microbiology in 2012. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between January and December in 2012 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standard Institutes. Susceptibility testing was evaluated in 1236 strains (232 Staphylococcus aureus, 225 Streptococcus pneumoniae, 16 Streptococcus pyogenes, 231 Haemophilus influenzae, 147 Moraxella catarrhalis, 167 Klebsiella pneumoniae and 218 Pseudomonas aeruginosa). Ratio of methicillin-resistant S. aureus was 51.3%, and those of penicillin-intermediate S. pneumoniae was 0.4%. Among H. influenzae, 5.6% of them were found to be β-lactamase-producing ampicillin-resistant strains, and 37.2% to be β-lactamase-non-producing ampicillin-resistant strains. Extended spectrum β-lactamase-producing K. pneumoniae and multi-drug resistant P. aeruginosa with metallo β-lactamase were 4.2% and 3.2%, respectively. Continuous national surveillance is important to determine the actual situation of the resistance shown by bacterial respiratory pathogens to antimicrobial agents., (Copyright © 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
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28. Clinical characteristics and CHADS2 score in patients with heart failure and atrial fibrillation: insights from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD).
- Author
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Hamaguchi S, Kinugawa S, Matsushima S, Fukushima A, Yokota T, Sakakibara M, Yokoshiki H, Tsuchihashi-Makaya M, and Tsutsui H
- Subjects
- Aged, Aged, 80 and over, Atrial Fibrillation diagnosis, Female, Heart Failure diagnosis, Humans, Male, Middle Aged, Asian People ethnology, Atrial Fibrillation ethnology, Cardiology standards, Heart Failure ethnology, Registries standards, Severity of Illness Index
- Published
- 2014
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29. Hyponatremia is an independent predictor of adverse clinical outcomes in hospitalized patients due to worsening heart failure.
- Author
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Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Matsushima S, Sakakibara M, Ishimori N, Goto D, and Tsutsui H
- Subjects
- Aged, Aged, 80 and over, Cause of Death, Cohort Studies, Disease Progression, Female, Forecasting, Hospital Mortality, Hospitalization statistics & numerical data, Humans, Male, Middle Aged, Patient Readmission statistics & numerical data, Prognosis, Registries, Time Factors, Heart Failure etiology, Heart Failure mortality, Hyponatremia, Sodium blood
- Abstract
Background and Purpose: Hyponatremia is common and is associated with poor in-hospital outcomes in patients hospitalized with heart failure (HF). However, it is unknown whether hyponatremia is associated with long-term adverse outcomes. The purpose of this study was to clarify the characteristics, clinical status on admission, and management during hospitalization according to the serum sodium concentration on admission, and determine whether hyponatremia was associated with in-hospital as well as long-term outcomes in 1677 patients hospitalized with worsening HF on index hospitalization registered in the database of the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)., Methods and Subjects: We studied the characteristics and in-hospital treatment in 1659 patients hospitalized with worsening HF by using the JCARE-CARD database. Patients were divided into 2 groups according to serum sodium concentration on admission <135mEq/mL (n=176; 10.6%) or ≥135mEq/mL (n=1483; 89.4%)., Results: The mean age was 70.7 years and 59.2% were male. Etiology was ischemic in 33.9% and mean left ventricular ejection fraction was 42.4%. After adjustment for covariates, hyponatremia was independently associated with in-hospital death [adjusted odds ratio (OR) 2.453, 95% confidence interval (CI) 1.265-4.755, p=0.008]. It was significantly associated also with adverse long-term (mean 2.1±0.8 years) outcomes including all-cause death (OR 1.952, 95% CI 1.433-2.657), cardiac death (OR 2.053, 95% CI 1.413-2.983), and rehospitalization due to worsening HF (OR 1.488, 95% CI 1.134-1.953)., Conclusions: Hyponatremia was independently associated with not only in-hospital but also long-term adverse outcomes in patients hospitalized with worsening HF., (Copyright © 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2014
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30. Efficacy and safety of piperacillin/tazobactam versus biapenem in late elderly patients with nursing- and healthcare-associated pneumonia.
- Author
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Karino F, Miura K, Fuchita H, Koba N, Nishikawa E, Hotta T, Okimoto T, Iwamoto S, Tsubata Y, Tada M, Hamaguchi S, Honda T, Ohe M, Sutani A, Kuraki T, Takeyama H, and Isobe T
- Subjects
- Aged, Aged, 80 and over, Anti-Bacterial Agents adverse effects, Anti-Bacterial Agents therapeutic use, Cross Infection microbiology, Female, Hospitalization, Humans, Male, Penicillanic Acid adverse effects, Penicillanic Acid therapeutic use, Piperacillin adverse effects, Piperacillin therapeutic use, Piperacillin, Tazobactam Drug Combination, Pneumonia, Bacterial microbiology, Retrospective Studies, Sputum microbiology, Cross Infection drug therapy, Penicillanic Acid analogs & derivatives, Pneumonia, Bacterial drug therapy, Thienamycins adverse effects, Thienamycins therapeutic use
- Abstract
Pneumonia is associated with an extremely high mortality rate in patients of late elderly age. Piperacillin/tazobactam and carbapenems are drugs of first choice for hospitalized patients with potentially resistant bacteria. We compared the efficacy and safety of piperacillin/tazobactam and biapenem. Among elderly patients with nursing- and healthcare-associated pneumonia, we extracted 53 patients treated with piperacillin/tazobactam and 53 patients treated with biapenem who were matched for sex, age, and severity of pneumonia. The average age was more than 80 years; most of the patients were middle- to oldest old in age. Although clinical efficacy was equally good, patients in the piperacillin/tazobactam group achieved significantly faster improvements on chest X-ray and body temperature on day 7. However, in the piperacillin/tazobactam group, nephrotoxicity frequently led to a need for a reduction in the dose or complete discontinuation of treatment. The average age of patients who developed significant nephrotoxicity was high, at 83.2 years. The biapenem group exhibited significantly better continuation of treatment than the piperacillin/tazobactam group. Toxicity profiles were different between the two groups. Hepatic toxicity was significantly higher in the biapenem group, whereas nephrotoxicity was significantly more common in the piperacillin/tazobactam group. Rate of decrease in bacteria was equally good between the two groups. Providing careful follow-up and conducting more detailed examinations, including studies to determine optimal dose and timing of administration, are necessary for the treatment of late elderly patients with numerous underlying diseases and potential organ dysfunctions.
- Published
- 2013
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31. Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD).
- Author
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Hamaguchi S, Kinugawa S, Tsuchihashi-Makaya M, Goto D, Yamada S, Yokoshiki H, and Tsutsui H
- Subjects
- Aged, Aged, 80 and over, Asian People, Cohort Studies, Disease Progression, Female, Heart Failure etiology, Heart Failure mortality, Hospital Mortality, Humans, Length of Stay, Male, Middle Aged, Myocardial Ischemia complications, Natriuretic Agents therapeutic use, Natriuretic Peptide, Brain therapeutic use, Prospective Studies, Random Allocation, Treatment Outcome, Angiotensin II Type 1 Receptor Blockers therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Atrial Natriuretic Factor therapeutic use, Heart Failure drug therapy, Hospitalization, Registries
- Abstract
Background: The characteristics, in-hospital management, and outcomes of patients hospitalized with worsening heart failure (HF) have been described by large-scale registries performed mainly in the USA and Europe. However, little information is available in Japan. We thus clarified the characteristics and clinical status as well as in-hospital management and outcomes among patients hospitalized with worsening HF in Japan and compared them with those reported in previous studies., Methods: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) studied prospectively the characteristics and treatments in patients hospitalized with worsening HF. From the total cohort of JCARE-CARD, 1677 patients were randomly selected and their detailed data during acute phase were collected as another registry database in the present study. The characteristics, in-hospital management, and outcomes were analyzed., Results: The mean age was 70.7 years and 59.4% were male. Etiology was ischemic in 34.0% and mean left ventricular ejection fraction was 42.5%. Carperitide was highly used as in-hospital management in Japan (33.5%) compared to the use of nesiritide in the USA (8-11%). The use of angiotensin-converting enzyme inhibitors was lower and angiotensin II receptor blockers (ARB) were more commonly used in this study compared to other studies in the USA and Europe. In-hospital crude mortality rate was comparable among studies (4-8%), however, length of stay was longer in Japan (15-20 versus 4-9 days)., Conclusions: The characteristics, clinical status, and laboratory data on admission in patients hospitalized with worsening HF were similar between the present study and previous Japanese and western studies. Management was also similar except for higher use of carperitide and ARB. The most striking difference between Japanese registries and those from the USA and Europe was the longer length of stay., (Copyright © 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2013
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32. Clinical characteristics and outcomes of dilated phase of hypertrophic cardiomyopathy: report from the registry data in Japan.
- Author
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Goto D, Kinugawa S, Hamaguchi S, Sakakibara M, Tsuchihashi-Makaya M, Yokota T, Yamada S, Yokoshiki H, and Tsutsui H
- Subjects
- Aged, Cardiomyopathy, Dilated epidemiology, Cardiomyopathy, Hypertrophic epidemiology, Female, Follow-Up Studies, Humans, Japan epidemiology, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Prospective Studies, Risk, Cardiomyopathy, Dilated complications, Cardiomyopathy, Hypertrophic complications, Heart Failure etiology, Heart Failure mortality, Registries
- Abstract
Background: A subset of patients with hypertrophic cardiomyopathy (HCM) has been reported to progress into dilated-HCM (D-HCM), characterized by left ventricular (LV) systolic dysfunction and cavity dilatation, resembling idiopathic dilated cardiomyopathy (DCM). We compared the characteristics, treatments, and outcomes in patients with heart failure (HF) due to D-HCM vs. DCM by using national registry data in Japan., Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) is a prospective observational study of patients hospitalized due to worsening HF with an average of 2.2 years of follow-up. Patients with D-HCM (n=41) were more likely to be male, have prior stroke, atrial fibrillation, and sustained ventricular tachycardia or ventricular fibrillation compared with DCM (n=486). Echocardiography demonstrated that D-HCM patients had smaller LV end-systolic diameter, higher ejection fraction, and greater wall thickness. Treatments for HF including angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, β-blocker, and spironolactone were similar between groups except for higher use of amiodarone, warfarin, and implantable cardioverter-defibrillator for D-HCM. Mortality was significantly higher in patients with D-HCM (29.7% vs. 14.4%; p<0.05). Sudden death tended to be higher also in D-HCM (8.1% vs. 2.6%; p=0.06), which, however, did not reach statistical significance., Conclusions: HF patients with D-HCM had higher mortality risk than those with DCM. Effective management strategies are critically needed to be established for D-HCM., (Copyright © 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2013
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33. Methicillin-resistant Staphylococcus aureus bacteremia at a university hospital in Japan.
- Author
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Isobe M, Uejima E, Seki M, Yamagishi Y, Miyawaki K, Yabuno K, Masaoka M, Hamaguchi S, Yoshioka N, and Tomono K
- Subjects
- Adult, Aged, Aged, 80 and over, Bacteremia prevention & control, Bacteremia therapy, Chi-Square Distribution, Cross Infection prevention & control, Cross Infection therapy, Female, Hospitals, University, Humans, Infection Control, Japan, Male, Middle Aged, Retrospective Studies, Staphylococcal Infections prevention & control, Staphylococcal Infections therapy, Survival Analysis, Bacteremia microbiology, Cross Infection microbiology, Methicillin-Resistant Staphylococcus aureus isolation & purification, Staphylococcal Infections microbiology
- Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) has become a leading cause of infections in hospitals, and mortality from MRSA bacteremia is high. In this study, we assessed the clinical characteristics and optimum management of 115 patients with MRSA bacteremia who were admitted to Osaka University Hospital between January 2006 and December 2010. Sixty-nine of the patients survived and 46 died of heart failure or renal failure. The nonsurvivors had reduced levels of platelets and albumin, and increased aspartate aminotransferase, total bilirubin, blood urea nitrogen, and creatinine levels. Other causes of death included sepsis, septic shock plus respiratory failure, disseminated intravascular coagulation, and unknown causes. However, a significant number of those whose infections were catheter-derived survived. Nonsurvivors were more often administered catecholamines and consultation with an infection-control team (ICT) was significantly associated with improved survival. Patients about whom the ICT were consulted were administered significantly more additional anti-MRSA drugs, for example trimethoprim-sulfamethoxazole, clindamycin, and gentamycin, than patients who were not the subject of consultation, although trough values for vancomycin did not differ between the two groups. Catheter removal was significantly higher for surviving patients with severe or complicated infections. These results suggest the status of patients with MRSA bacteremia who did not survive was worse than those who did survive, but that ICT consultation might significantly affect survival by recommendation of appropriate care and anti-MRSA drug use.
- Published
- 2012
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34. Labdane-type diterpenoids from hairy root cultures of Coleus forskohlii, possible intermediates in the biosynthesis of forskolin.
- Author
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Asada Y, Li W, Terada T, Kuang X, Li Q, Yoshikawa T, Hamaguchi S, Namekata I, Tanaka H, and Koike K
- Subjects
- Coleus chemistry, Colforsin analogs & derivatives, Culture Techniques, Diterpenes chemistry, Models, Molecular, Molecular Conformation, Monoterpenes chemistry, Plant Roots metabolism, Coleus growth & development, Coleus metabolism, Colforsin metabolism, Diterpenes isolation & purification, Diterpenes metabolism, Plant Roots chemistry
- Abstract
Significant attention has been devoted to studying hairy root cultures as a promising strategy for production of various valuable secondary metabolites. These offer many advantages, such as high growth rate, genetic stability and being hormone-free. In this study, a detailed phytochemical investigation of the secondary metabolites of Coleus forskohlii hairy root cultures was undertaken and which resulted in the isolation of 22 compounds, including four forskolin derivatives and a monoterpene. Their structures were elucidated by extensive spectroscopic analyses. These compounds could be classified into four groups viz.: labdane-type diterpenes, monoterpenes, triterpenes and phenylpropanoid dimers. Apart from one compound, all labdane type diterpenes are oxygenated at C-11 as in forskolin and a scheme showing their biosynthetic relationships is proposed., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
35. A case of retained placenta increta successfully treated via uterine arterial embolization using N-butyl 2-cyanoacrylate.
- Author
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Hamaguchi S, Okura N, Yoshimatsu M, Ogawa Y, Takizawa K, and Nakajima Y
- Subjects
- Adult, Female, Humans, Postpartum Hemorrhage etiology, Pregnancy, Enbucrilate therapeutic use, Placenta Accreta therapy, Postpartum Hemorrhage therapy, Tissue Adhesives therapeutic use, Uterine Artery Embolization
- Abstract
A 29-year-old woman with placenta increta with hemorrhage underwent uterine artery embolization using 12.5% NBCA (N-butyl 2-cyanoacrylate) diluted with iodized oil (Lipiodol). Complete resolution of placenta increta without performing curettage was obtained. The uterus returned to its normal shape, with restored endometrium, junctional zone, and myometrium. Menstruation resumed after 3 months. In cases of retained placenta due to placenta accreta, and even those with placenta increta, uterine artery embolization using NBCA is a useful treatment., (Copyright © 2012 AAGL. Published by Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
36. Two cases of tracheoinnominate artery fistula following tracheostomy treated successfully by endovascular embolization of the innominate artery.
- Author
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Hamaguchi S and Nakajima Y
- Subjects
- Adolescent, Brachiocephalic Trunk diagnostic imaging, Child, Female, Hemorrhage etiology, Hemorrhage therapy, Humans, Male, Radiography, Respiratory Tract Fistula diagnostic imaging, Respiratory Tract Fistula etiology, Tracheal Diseases diagnostic imaging, Tracheal Diseases etiology, Treatment Outcome, Vascular Fistula diagnostic imaging, Vascular Fistula etiology, Brachiocephalic Trunk injuries, Embolization, Therapeutic, Respiratory Tract Fistula therapy, Tracheal Diseases therapy, Tracheostomy adverse effects, Vascular Fistula therapy
- Abstract
Tracheoinnominate artery fistula (TIF) is a rare but lethal complication of tracheostomy. Treatment has traditionally been surgical, but advances in endovascular technology have led to a few recent reports of therapy with coils. We report 2 cases of TIF with massive hemorrhage that underwent successful treatment with endovascular occlusion. Endovascular repair is less invasive than open surgical repair and usually associated with a shorter recovery period. However, this technique may require multiple coils to inhibit blood flow into the fistula. This procedure should be considered one of the useful treatments for TIF., (Copyright © 2012 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
37. Hyperuricemia predicts adverse outcomes in patients with heart failure.
- Author
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Hamaguchi S, Furumoto T, Tsuchihashi-Makaya M, Goto K, Goto D, Yokota T, Kinugawa S, Yokoshiki H, Takeshita A, and Tsutsui H
- Subjects
- Aged, Cause of Death trends, Disease Progression, Female, Follow-Up Studies, Heart Failure blood, Heart Failure mortality, Humans, Hyperuricemia blood, Hyperuricemia epidemiology, Japan epidemiology, Male, Patient Readmission trends, Prognosis, Survival Rate trends, Heart Failure complications, Hyperuricemia etiology, Uric Acid blood
- Abstract
Background: Hyperuricemia is associated with worse outcomes of patients with chronic heart failure (HF). However, it is unknown in an unselected HF patients encountered in routine clinical practice. We thus assessed the impact of hyperuricemia on long-term outcomes including mortality and rehospitalization among patients hospitalized with worsening HF., Methods: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) studied prospectively the characteristics and treatments in a broad sample of hospitalized HF patients and the outcomes were followed for 2.1 years after discharge. Study cohorts (n=1869) were divided into 2 groups according to serum uric acid (UA) at discharge; ≥ 7.4 mg/dL (n=908) and <7.4 mg/dL (n=961)., Results: Of the total cohort of HF patients, 56% had hyperuricemia defined as UA ≥ 7.0mg/dl. Patients with UA ≥ 7.4 mg/dL had higher rates of all-cause death, cardiac death, rehospitalization, and all-cause death or rehospitalization due to worsening HF. After multivariable adjustment, higher UA levels were a significant and independent predictor for all-cause death (adjusted hazard ratio [HR] 1.413, 95% confidence interval [CI] 1.094-1.824, P=0.008) and cardiac death (adjusted HR 1.399, 95% CI 1.020-1.920, P=0.037)., Conclusions: Hyperuricemia was common in patients with HF encountered in clinical practice and higher UA was independently associated with long-term adverse outcomes in these patients., (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
38. Sex differences with respect to clinical characteristics, treatment, and long-term outcomes in patients with heart failure.
- Author
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Tsuchihashi-Makaya M, Hamaguchi S, Kinugawa S, Goto K, Goto D, Furumoto T, Yamada S, Yokoshiki H, Takeshita A, and Tsutsui H
- Subjects
- Aged, Aged, 80 and over, Databases, Factual trends, Female, Humans, Male, Middle Aged, Time Factors, Treatment Outcome, Heart Failure physiopathology, Heart Failure therapy, Sex Characteristics
- Published
- 2011
- Full Text
- View/download PDF
39. Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish.
- Author
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Wada H, Ghysen A, Satou C, Higashijima S, Kawakami K, Hamaguchi S, and Sakaizumi M
- Subjects
- Animals, Animals, Genetically Modified, Bone and Bones embryology, Dermis cytology, Dermis growth & development, Embryo, Nonmammalian, Immunohistochemistry, In Situ Hybridization, Lateral Line System cytology, Mechanoreceptors cytology, Microinjections, Microscopy, Video, Models, Biological, Oligonucleotides, Antisense metabolism, Oryzias embryology, Species Specificity, Zebrafish embryology, Body Patterning, Lateral Line System growth & development, Morphogenesis, Oryzias growth & development, Zebrafish growth & development
- Abstract
The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic development in zebrafish. We also show that accessory neuromast formation is highly correlated to the development of underlying dermal structures such as bones and scales. Abnormalities in opercular bone morphogenesis, in endothelin 1-knockdown embryos, are accompanied by stereotypic errors in neuromast budding and positioning, further demonstrating the tight correlation between the patterning of neuromasts and of the underlying dermal bones. In medaka, where scales form between peridermis and opercular bones, the lateral line displays a scale-specific pattern which is never observed in zebrafish. These results strongly suggest a control of postembryonic neuromast patterns by underlying dermal structures. This dermal control may explain some aspects of the evolution of lateral line patterns., (Copyright (c) 2010 Elsevier Inc. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
40. Effects of landiolol on QT interval and QT dispersion during induction of anesthesia using computerized measurement.
- Author
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Kaneko M, Yamaguchi S, Hamaguchi S, Egawa H, Fujii K, Ishikawa K, Kitajima T, and Minami J
- Subjects
- Adult, Anesthesiology methods, Blood Pressure drug effects, Double-Blind Method, Female, Heart physiology, Humans, Intubation, Intratracheal, Male, Medical Records Systems, Computerized, Middle Aged, Treatment Outcome, Urea pharmacology, Young Adult, Adrenergic beta-Antagonists pharmacology, Anesthesia methods, Anesthesiology instrumentation, Electrocardiography drug effects, Heart drug effects, Morpholines pharmacology, Urea analogs & derivatives
- Abstract
Study Objective: To examine the effects of landiolol on the QT interval, rate-corrected QT (QTc) interval, QT dispersion (QTD), and rate-corrected QTD (QTcD) during tracheal intubation using computerized measurement., Design: Randomized, double-blinded study., Setting: Dokkyo Medical University Hospital operating room., Patients: 30 ASA physical status I patients scheduled for elective surgery., Inventions: Patients were randomized to receive either normal saline (saline group) or landiolol (landiolol group; one-min loading infusion of 0.125 mg/kg followed by 0.04 mg/kg/min infusion). Immediately after the start of administration of saline or landiolol, anesthesia was induced with intravenous (IV) fentanyl two microg/kg, propofol 1.5 mg/kg, and vecuronium 0.1 mg/kg. Six minutes after administration of saline or landiolol, tracheal intubation was performed within 20 seconds., Measurements: Mean arterial pressure (MAP), RR interval, QT interval, QTc interval, QTD, and QTcD were consecutively recorded during the induction., Main Results: There was no significant difference in MAP between groups during the study. RR interval in the landiolol group was significantly longer than in the saline group from two minutes after the start of the landiolol infusion to the end of the study. The QT interval in the landiolol group was significantly shorter than in the saline group from start of the infusion to 4 minutes after tracheal intubation. The QTc interval, QTD, and QTcD in the landiolol group were significantly shorter than those in the saline group from immediately after tracheal intubation to the end of study., Conclusion: A bolus of landiolol 0.125 mg/kg followed by an infusion of landiolol 0.04 mg/kg/min may reduce the risk of cardiac arrhythmias during induction of anesthesia.
- Published
- 2009
- Full Text
- View/download PDF
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