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2. Contributors

Author

Abdelhamid, Hani Nasser, primary, Ahmad, Khursheed, additional, Almessiere, M.A., additional, Analisa, S., additional, Araujo, Robson Teixeira, additional, Ashok Kumar, S., additional, Asiri, Abdullah M., additional, Atacan, Keziban, additional, Baykal, A., additional, Bhatia, Amarpreet K., additional, Bhushan, Mayank, additional, Boddula, Rajender, additional, Bucio, Emilio, additional, Camacho-Cruz, Luis A., additional, Carabineiro, Sónia A.C., additional, Cedillo-Valverde, Gerardo, additional, Chavda, Nitya, additional, Chokkareddy, Rajasekhar, additional, Cruz-Gómez, Angélica, additional, Daphne, V., additional, Dewangan, Shippi, additional, Dinesh, A., additional, Durka, M., additional, Gaddam, Sashivinay Kumar, additional, Güy, Nuray, additional, Gupta, Vikas, additional, Gupta, Rachna, additional, Hashemi-Moghaddam, Hamid, additional, Inbanathan, S.S.R., additional, Jaganathan, S.K., additional, Jain, Ankit, additional, Jarvin, M., additional, Julie, M. Maria, additional, Kabane, Bakusele, additional, Kanchi, Suvardhan, additional, Kanmani Raja, K., additional, Katari, Naresh Kumar, additional, Keerthana, C., additional, Kesharwani, Payal, additional, Khan, Anish, additional, Kilele, Joan Chepkoech, additional, Kim, Haekyoung, additional, Kumar, K. Elaya, additional, Kumar, Amit, additional, Kumar, R. Thilak, additional, Kumari, Mahima, additional, Laishram, Robindro Singh, additional, Machado, Fabricio, additional, Malik, Parth, additional, Malik, Maqsood Ahmad, additional, Manikandan, Ayyar, additional, Muthulingam, S., additional, Neto, Weslany Silvério, additional, Nivetha, P., additional, Prajapati, Shiv Kumar, additional, Rajikha, R., additional, Ramyakrishna, Pothu, additional, Ratna Monica, J. Helen, additional, Redhi, Gan G., additional, Resende, Graciane, additional, Rosaline, D. Rani, additional, Rubini, S. Hamsa, additional, Sampath, Shobana, additional, Sathana, V., additional, Sharma, Bhasha, additional, Sharma, Kanika, additional, Sharma, Swapnil, additional, Sheha, Reda R., additional, Shekhar, Shashank, additional, Shinde, Mahesh A., additional, Simões Dutra, Gabriel Victor, additional, Singh, Ajaya Kumar, additional, Slimani, Y., additional, Somya, Amita, additional, Srividya, G., additional, Susan, Md. Abu Bin Hasan, additional, Sykam, Kesavarao, additional, Thanrasu, K., additional, Topare, Niraj S., additional, Vasthi, S. Stephila, additional, and Velazco-Medel, Marlene A., additional

Published
2024
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4. Toxicology in drug research

Author

Mishra, Ankit, primary, Mishra, Pranali, additional, Tekade, Muktika, additional, Gupta, Rachna, additional, Rajpoot, Kuldeep, additional, Mohamed, Farahidah, additional, and Tekade, Rakesh Kumar, additional

Published
2023
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5. List of contributors

Author

Achanta, Nagendra Sai Kumar, primary, Al-Attraqchi, Omar Husham Ahmed, additional, Al-Shar'i, Nizar, additional, Anup, Neelima, additional, Arafat, Basel, additional, Bain, Anoothi, additional, Bansal, Kuldeep Kumar, additional, Behera, Santosh Kumar, additional, Chauhan, Nagendra Singh, additional, Chellappan, Dinesh Kumar, additional, Desai, Nimeet, additional, Deshpande, Mrudul, additional, Dhamne, Sneha A., additional, Dixit, Pankaj Vinodrao, additional, Gadeval, Anuradha, additional, Gandhi, Sanyam, additional, Gomte, Shyam, additional, Gondaliya, Piyush, additional, Gupta, Deepak Kumar, additional, Gupta, Rachna, additional, Gupta, Tanisha, additional, Ingole, Shweta, additional, Joshi, Megha, additional, Kalpeshkumar, Rana Dhwani, additional, Koppisetti, Hari Priya, additional, Kulkarni, Madhur, additional, Kumar, Manoj, additional, Lohar, Priyanka, additional, Maheshwari, Rahul, additional, Mansour, Randa SH., additional, Mhatre, Mahi, additional, Mishra, Ankit, additional, Mishra, Dinesh Kumar, additional, Mishra, Pranali, additional, Mohamed, Farahidah, additional, More, Anand, additional, Nalla, Lakshmi Vineela, additional, Panchal, Mamata, additional, Pardeshi, Krutika H., additional, Pawar, Bhakti, additional, Pawar, Vinayak, additional, Pingale, Prashant L., additional, Pingale, Anjali, additional, Polaka, Suryanarayana, additional, Raji, Sivarupa, additional, Rajpoot, Kuldeep, additional, Rajput, Amarjitsing P., additional, Raval, Nidhi, additional, Safavi, Maliheh, additional, Sarker, Satyajit D., additional, Saudagar, Neetu R., additional, Sayyed, Adil Ali, additional, Sengupta, Pinaki, additional, Shakya, Ashok K., additional, Sharma, Manish Kumar, additional, Sharma, Manish, additional, Sharma, Mukesh C., additional, Sheth, Anjani, additional, Shukla, Havish, additional, Sreeharsha, Nagaraja, additional, Tambe, Vishakha, additional, Teja, Paritala Sree, additional, Tekade, Muktika, additional, Tekade, Rakesh Kumar, additional, Tiwari, Akhilesh, additional, Vasdev, Nupur, additional, Wani, Sakshi P., additional, and Wankhede, Yogesh, additional

Published
2023
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8. Factors influencing drug toxicity

Author

Gupta, Rachna, primary, Rajpoot, Kuldeep, additional, Tekade, Muktika, additional, Sharma, Mukesh Chandra, additional, Safavi, Maliheh, additional, and Tekade, Rakesh Kumar, additional

Published
2022
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10. List of contributors

Author

Arafat, Basel, primary, Asati, Saket, additional, Bagul, Swati, additional, Behera, Santosh Kumar, additional, Borisa, Pooja, additional, Chatterjee, Bappaditya, additional, Chaudhari, Sayali, additional, Christian, Jenee R., additional, Desai, Nimeet, additional, Deshpande, Mrudul, additional, Gandhi, Sanyam, additional, Gomte, Shyam Sudhakar, additional, Gour, Vishal, additional, Gupta, Deepak, additional, Gupta, Rachna, additional, Jhariya, Aditya Narayan, additional, Joshi, Megha, additional, Katare, Pratik, additional, Koppisetti, Hari Priya, additional, Koppisetti, HariPriya, additional, Kulkarni, Madhur, additional, Kumar, Manoj, additional, Lingayat, Isha, additional, Makwana, Vaishali, additional, Malviya, Neelesh, additional, Malviya, Sapna, additional, Manchikalapudi, Aparna Lakshmi, additional, Mishra, Ankit, additional, Mishra, Dinesh Kumar, additional, Mishra, Pranali, additional, Molugulu, Nagashekhara, additional, Muthuvijayan, Vignesh, additional, Nalla, Lakshmi Vineela, additional, Pande, Shreya, additional, Pandey, Vikas, additional, Parikh, Kinjal J., additional, Pawar, Bhakti, additional, Petwal, Aditi, additional, Pingale, Prashant, additional, Polaka, Suryanarayana, additional, Pramanik, Sheersha, additional, Pulugu, Priyanka, additional, Rajani, Chitra, additional, Raji, Sivaroopa, additional, Rajpoot, Kuldeep, additional, Rajput, Amarjitsing, additional, Safavi, Maliheh, additional, Salvi, Neelima, additional, Satvase, Rutuja, additional, Sengupta, Pinaki, additional, Sharma, Mukesh Chandra, additional, Shukla, Kajal, additional, Soni, Vandana, additional, Tambe, Vishakha, additional, Tekade, Muktika, additional, Tekade, Rakesh Kumar, additional, Tella, Jai Divya, additional, Tiwari, Akhilesh, additional, Tiwari, Rahul, additional, and Vasdev, Nupur, additional

Published
2022
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12. List of contributors

Author

Alvarez-Puebla, Ramon A., primary, Ameta, Rakesh Kumar, additional, Anandan, Sambandam, additional, Ansari, Shahid Pervez, additional, Asiri, Abdullah M., additional, Babu, D. Prakash, additional, Banerjee, Prasun, additional, Chandra Babu Naidu, K., additional, Deepa, C., additional, Elakkiya, Rajasekaran, additional, Eswara Rao, P C.V.V., additional, Franco, Adolfo, additional, Guerrini, Luca, additional, Gupta, Rachna, additional, Gurusamy, Lakshmanan, additional, Herrera-Herrera, Antonio V., additional, Husain, Ahmad, additional, Janardan, S., additional, Khan, Anish, additional, Kumar, G. Ranjith, additional, Kumar, N. Suresh, additional, Kuppuswamy, N., additional, Maduraiveeran, Govindhan, additional, Malik, Parth, additional, Manjunatha, H., additional, Muthukrishnan, M., additional, Natarajan, Srinivasan, additional, Ni, Wei, additional, Noorjahaan, M., additional, Praveen, S., additional, Ramesh, M., additional, Ramesh, S., additional, Ramezanzadeh, Bahram, additional, Ramezanzadeh, Mohammad, additional, Rao, L. Vaikunta, additional, Ratnam, K. Venkata, additional, Ratnamala, A., additional, Reddy, G. Deepthi, additional, Reddy, K. Rama Krishna, additional, Rodríguez Delgado, Miguel Ángel, additional, Rodríguez-Ramos, Ruth, additional, Santana-Mayor, Álvaro, additional, Shariq, Mohd Urooj, additional, Sivarmakrishna, A., additional, Socas Rodríguez, Bárbara, additional, Srinivas, K., additional, Suresh Kumar, N., additional, Venkata Shiva Reddy, B., additional, Wu, Jerry J., additional, and Zorlu, Tolga, additional

Published
2021
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13. Bupropion monotherapy alters neurotrophic and inflammatory markers in patients of major depressive disorder.

Author

Tafseer S, Gupta R, Ahmad R, Jain S, Bhatia MS, and Gupta LK

Subjects
Adolescent, Adult, Biomarkers blood, Depressive Disorder, Major blood, Female, Humans, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Treatment Outcome, Young Adult, Antidepressive Agents, Second-Generation therapeutic use, Brain-Derived Neurotrophic Factor blood, Bupropion therapeutic use, Depressive Disorder, Major drug therapy, Tumor Necrosis Factor-alpha blood
Abstract

Background: Emerging hypotheses in the pathophysiology of major depressive disorder (MDD) indicate the role of neurotrophic factors and inflammation. This study assessed the association between therapeutic response of bupropion and serum brain-derived neurotrophic factor (BDNF) and tumour necrosis factor-α (TNF-α) levels in patients with MDD., Methods: Thirty patients (aged 18 to 60 years) with MDD diagnosed by DSM-5 criteria, with Hamilton Depression Rating scale (HAM-D) score ≥ 20 were included in the study. Patients were given bupropion sustained release (SR) in the doses of 150 mg once daily. All patients were followed up for 12 weeks., Results: HAM-D score at the start of the treatment was 25.57 ± 1.85 which significantly reduced to 10.8 ± 4.24 at 12 weeks of treatment. The serum BDNF level increased significantly (p < 0.05) from 2.42 ± 0.19 ng/ml to 2.97 ± 0.10 ng/ml and the levels of serum TNF-α reduced significantly (p < 0.05) from 4.45 ± 0.95 pg/ml to 2.11 ± 0.84 pg/ml at 12 weeks of treatment, in responders to treatment., Conclusion: The results of our study suggest that bupropion SR monotherapy is effective and well tolerated in MDD patients with moderate to severe depression, and its therapeutic efficacy is accompanied by an increase in serum BDNF levels and a decrease in serum TNF-α levels., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Published
2021
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14. Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer's disease.

Author

Gupta R and Gupta LK

Subjects
Alzheimer Disease psychology, Animals, Blood Glucose analysis, Body Weight drug effects, Male, Maze Learning, Mice, PPAR gamma agonists, Pioglitazone, Thiazolidinediones administration & dosage, Alzheimer Disease drug therapy, Disease Models, Animal, Memory Disorders drug therapy, Thiazolidinediones therapeutic use
Abstract

Peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists (thiazolidinediones) are widely prescribed for the treatment of type-II diabetes mellitus. Recently, PPAR-γ agonists have shown neuroprotective effects in neurodegenerative disorders. The current study was carried out to investigate the effects of chronic administration of pioglitazone, a PPAR-γ agonist, on cognitive impairment in a mouse model of Alzheimer's disease induced by scopolamine. Scopolamine was administered in a dose of 1mg/kg intraperitoneally (i.p.). Cognitive functions were assessed using step-down latency (SDL) on a passive avoidance apparatus and escape latency in Morris water maze test. Pioglitazone was also investigated for its effects on parameters of oxidative stress by measuring malondialdehyde (MDA) and reduced glutathione (GSH) levels in the brain. Scopolamine produced significant reduction in SDL and prolongation of escape latency indicating cognitive impairment in mice. Pioglitazone (20 and 40 mg/kg, i.p.), administered for 21 days, showed significant dose-dependent improvement in scopolamine-induced dysfunctions in long-term and visuo-spatial memory in passive avoidance and Morris water maze tests, respectively. Furthermore, pioglitazone significantly prevented the fall in GSH levels and elevation in brain MDA levels induced by scopolamine. These results demonstrate that pioglitazone offers protection against scopolamine-induced dysfunctions in long-term and visuo-spatial memory, possibly due to its antioxidant action, and therefore, could have a therapeutic potential in Alzheimer's disease., (Copyright © 2012 Elsevier Inc. All rights reserved.)

Published
2012
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15. Genital herpes.

Author

Gupta R, Warren T, and Wald A

Subjects
Adult, Condoms statistics & numerical data, Female, Herpesvirus 1, Human isolation & purification, Herpesvirus 2, Human isolation & purification, Humans, Infant, Newborn, Infant, Newborn, Diseases prevention & control, Infant, Newborn, Diseases virology, Infectious Disease Transmission, Vertical prevention & control, Male, Secondary Prevention, Antiviral Agents therapeutic use, Herpes Genitalis drug therapy, Herpes Genitalis physiopathology, Herpes Genitalis prevention & control, Herpesvirus 1, Human pathogenicity, Herpesvirus 2, Human pathogenicity
Abstract

Genital herpes is the main cause of genital ulcers worldwide; the prevalence of herpes simplex virus (HSV) type 2 infections in the general population ranges from 10% to 60%. Most genital herpes is caused by HSV-2, although HSV-1 accounts for about half of new cases in developed countries. The risk of HIV acquisition is three times higher in people with HSV-2. Neonatal herpes is an uncommon but serious complication of genital herpes. Most genital HSV-2 infections are unrecognised and undiagnosed; infected individuals, even with mild symptoms, shed HSV, and can infect sexual partners. Since clinical diagnosis is neither sensitive nor specific, virological and type-specific serological tests should be used routinely. Oral antiviral drugs for HSV infections are safe and effective and can be used both to treat episodes and to prevent recurrences. Antiviral treatment of the infected partners and condom use reduce the risk of sexual transmission of HSV-2.

Published
2007
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16. Novel copper(II) homobinuclear macrocyclic complexes: cyclic voltammetry, biological properties and spectral studies.

Author

Chandra S, Gupta N, and Gupta R

Subjects
Anti-Bacterial Agents chemistry, Electrochemistry methods, Enterococcus faecalis metabolism, Escherichia coli metabolism, Ligands, Macrocyclic Compounds, Magnetics, Metals, Heavy, Models, Chemical, Molecular Structure, Oxidation-Reduction, Potentiometry, Spectrophotometry, Infrared, Stereoisomerism, Ultraviolet Rays, Copper chemistry, Electron Spin Resonance Spectroscopy methods
Abstract

A series of five new copper(II) macrocyclic complexes have been synthesized by template condensation. The bonding and stereochemistry of the complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility, IR, UV-visible, EPR spectral studies and electrochemical properties. g-Values are calculated for all of the complexes in polycrystalline form as well as in DMSO solution. The magnetic and spectral data indicate square planar geometry for all the complexes. Cyclic voltammograms for all the complexes are similar and involve two quasi-reversible redox processes. Cu(II)Cu(II)<=>Cu(II)Cu(I)<=>Cu(I)Cu(I). Their biological properties have also been studied. The macrocyclic complexes show more anti-bacterial than controlled one. The anti-bacterial activities of the compounds were tested against Streptococcus fecalis and Escherichia coli with different concentrations.

Published
2006
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17. EPR, UV-vis, magnetic, spectral studies and electrochemical behaviour of mononuclear transition metal complexes derived from novel hexa-aza-macrotricyclic ligand.

Author

Chandra S, Gupta N, Gupta R, and Bawa SS

Subjects
Aza Compounds chemistry, Electrochemistry, Electron Spin Resonance Spectroscopy, Ligands, Models, Molecular, Spectrophotometry, Spectrophotometry, Ultraviolet, Heterocyclic Compounds chemistry, Metals chemistry
Abstract

Aza-macrocyclic complexes have gained importance because of their pharmacological properties. Hexa-aza-macrocycles containing glutarimide efficiently coordinate as hexa-dentate ligand, to give complexes of Cu(II) possessing tetragonal structure and Mn(II), Co(II) and Ni(II) metal ions that are essentially octahedral. Spectroscopic, and chemical characterizations of these systems are presented in this article. For Ni(II) complexes results on electron transfer processes measured by cyclic voltammetry and colourimetry have been studied.

Published
2005
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18. Magnetic, electronic and electrochemical studies of mono and binuclear Cu(II) complexes using novel macrocyclic ligands.

Author

Gupta N, Gupta R, Chandra S, and Bawa SS

Subjects
Catechols chemistry, Catechols metabolism, Copper metabolism, Electron Spin Resonance Spectroscopy, Ligands, Macrocyclic Compounds metabolism, Magnetics, Molecular Structure, Oxidation-Reduction, Copper chemistry, Electrochemistry, Macrocyclic Compounds chemistry, Nanotubes, Carbon chemistry
Abstract

A series of new mono and binuclear copper (II) complexes [Cul]X(2)and [Cu(2)lX(2)] where 1 = L(1), L(2) and L(3) are the macrocyclic ligands. In mononuclear complexes the geometry of Cu(II) ion is distorted squareplanar and in binuclear complexes the geometry of Cu(II) is tetragonal. The synthesized complexes were characterized by spectroscopic (IR,UV-vis and ESR) techniques. Electrochemical studies of the complexes reveals that all the mononuclear Cu(II) complexes show a single quasireversible one-electron transfer reduction wave (E(pc) = -0.76 to -0.84V) and the binuclear complexes show two quasireversible one electron transfer reduction waves (E(pc)(1) = -0.86 to -1.01V, E(pc)(2) = -1.11 to -1.43V) in cathodic region. The ESR spectra of mononuclear complexes show four lines with nuclear hyperfine splittings with the observed g(11) values in the ranges 2.20-2.28, g( perpendicular) = 2.01-2.06 and A(11) = 125-273. The binuclear complexes show a broad ESR spectra with g = 2.10-2.11. The room temperature magnetic moment values for the mononuclear complexes are in the range [mu(eff) = 1.70-1.72BM] and for the binuclear complexes the range is [mu(eff) = 1.46-1.59BM].

Published
2005
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