1. Isolated lung perfusion for pulmonary metastases.
- Author
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Hendriks JM, Van Putte BP, Grootenboers M, Van Boven WJ, Schramel F, and Van Schil PE
- Subjects
- Animals, Chemotherapy, Cancer, Regional Perfusion instrumentation, Humans, Models, Animal, Rats, Antineoplastic Agents administration & dosage, Chemotherapy, Cancer, Regional Perfusion methods, Lung Neoplasms drug therapy, Lung Neoplasms secondary, Tumor Necrosis Factor-alpha administration & dosage
- Abstract
Isolated lung perfusion is an experimental surgical technique evaluated for the delivery of high-dose chemotherapy to improve 5-year survival after pulmonary metastasectomy. Extensive experimental work in animal models has demonstrated superior pharmacokinetics and efficacy compared with systemic therapy. Phase I clinical trials of isolated lung perfusion found a maximum tolerated dose**** of TNF-alpha, doxorubicin, cisplatin, and melphalan, whereas the combination of isolated lung perfusion with a complete metastasectomy was feasible. The combination of isolated lung perfusion and regional lung perfusion techniques needs further investigation.
- Published
- 2006
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