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2 results on '"Gordana Supic"'

1. List of Contributors

Author

Navneet Agnihotri, Dulce E. Alarcón-Yaquetto, Tania V. Altamirano, Pathan S. Begum, Adalberto Benavides-Mendoza, Priyanka Bhadwal, Eleftherios Bonos, Marcelino Cabrera-De la Fuente, Efterpi Christaki, Ana Ćirić, Luis M. Contreras-Medina, Nada Ćujić, Petko N. Denev, Ana A. Feregrino-Perez, Emmanuel Flores-Huicochea, Panagiota Florou-Paneri, Lina Garcia-Mier, Juan F. Garcia-Trejo, Yordan N. Georgiev, Ilias Giannenas, Jasmina Glamočlija, Susana González-Morales, Gustavo F. Gonzales, Ramon G. Guevara-González, Teodora Janković, Sandra N. Jimenez-Garcia, Antonio Juárez-Maldonado, Nevena Kardum, Rabia Khalid, Maria G. Kratchanova, Sandeep Kumar, Paola Leija-Martínez, Vannucci Luca, Zvonko Magic, Edwin E. Martínez Leo, Nebojša Menković, Manol H. Ognyanov, Amanda Ortíz-Sánchez, Sima Petr, Jovana Petrović, Slavica Radjen, Senthilkumar Rajagopal, Meerza A. Razak, J. Rodolfo Rendón-Villalobos, Danijela Ristić-Medić, Supraj R. Sangam, Katarina Šavikin, Bhoomika Sharma, Prerna Sharma, Maira R. Segura Campos, Mian K. Sharif, Shubham Singh, Marina Soković, Dejan Stojković, Gordana Supic, Marija Takić, Vetvicka Vaclav, Moises A. Vazquez-Cruz, Buddolla Viswanath, Gordana Zdunić, and Katarina Zeljic

Published
2018
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2. Epigenetic Nutraceuticals in Cancer Treatment

Author

Zvonko Magic, Katarina Zeljic, and Gordana Supic

Subjects
0301 basic medicine, Regulation of gene expression, Methyltransferase, biology, Cancer, Computational biology, medicine.disease, 3. Good health, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Histone, chemistry, 030220 oncology & carcinogenesis, DNA methylation, Gene expression, biology.protein, medicine, Epigenetics, DNA
Abstract

Epigenetics describes changes in gene expression not coded by the DNA sequence, and the classical mechanisms include DNA methylation and histone modifications. More recently, noncoding RNAs emerged as another potential mechanism of gene expression regulation. The inhibition of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), the enzymes that mediate epigenetic modifications, is a novel cancer therapeutic strategy. Emerging evidence strongly suggests that various bioactive dietary components and nutraceuticals exert their anticancer properties through epigenetic mechanisms. Nutritional epigenetics is a novel and complex scientific field focused on studying dietary bioactive components as epigenetic modulators in chemoprevention and therapy of complex diseases, particularly cancer. The precise mechanisms whereby phytochemicals and nutraceuticals influence epigenetic changes in human cancers, their cellular targets, as well as optimal doses, need to be further elucidated. However, the field of nutritional epigenetics seems to have very promising future in chemoprevention and treatment of cancer.

Published
2018
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