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Your search keyword '"Godoy Marín, Héctor"' showing total 2 results
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2 results on '"Godoy Marín, Héctor"'

1. Supplementary files The spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes

Author

Tarifa, Carmen [0000-0001-8954-6058], Jiménez-Sábado, Verónica [0000-0001-7720-988X], Hove-Madsen, Leif [0000-0001-5493-3998], Tarifa, Carmen, Vallmitjana, Alexander, Jiménez-Sábado, Verónica, Marchena, Miquel, Llach, Anna, Herraiz-Martínez, Adela, Godoy-Marín, Héctor, Nolla-Colomer, Carme, Ginel, Antonino, Viñolas, Xavier, Montiel, José, Ciruela, Francisco, Echebarria, Blas, Benítez, Raul, Cinca, Juan, Hove-Madsen, Leif, Tarifa, Carmen [0000-0001-8954-6058], Jiménez-Sábado, Verónica [0000-0001-7720-988X], Hove-Madsen, Leif [0000-0001-5493-3998], Tarifa, Carmen, Vallmitjana, Alexander, Jiménez-Sábado, Verónica, Marchena, Miquel, Llach, Anna, Herraiz-Martínez, Adela, Godoy-Marín, Héctor, Nolla-Colomer, Carme, Ginel, Antonino, Viñolas, Xavier, Montiel, José, Ciruela, Francisco, Echebarria, Blas, Benítez, Raul, Cinca, Juan, and Hove-Madsen, Leif

Published
2023

2. Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes

Author

Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Sanidad, Consumo y Bienestar Social (España), Generalitat de Catalunya, Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Sociedad Española de Cardiología, Fundació La Marató de TV3, Tarifa, Carmen, Vallmitjana, Alexander, Jiménez-Sábado, Verónica, Marchena, Miquel, Llach, Anna, Herraiz-Martínez, Adela, Godoy-Marín, Héctor, Nolla-Colomer, Carme, Ginel, Antonino, Viñolas, Xavier, Montiel, José, Ciruela, Francisco, Echebarria, Blas, Benítez, Raul, Cinca, Juan, Hove-Madsen, Leif, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Sanidad, Consumo y Bienestar Social (España), Generalitat de Catalunya, Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Sociedad Española de Cardiología, Fundació La Marató de TV3, Tarifa, Carmen, Vallmitjana, Alexander, Jiménez-Sábado, Verónica, Marchena, Miquel, Llach, Anna, Herraiz-Martínez, Adela, Godoy-Marín, Héctor, Nolla-Colomer, Carme, Ginel, Antonino, Viñolas, Xavier, Montiel, José, Ciruela, Francisco, Echebarria, Blas, Benítez, Raul, Cinca, Juan, and Hove-Madsen, Leif

Abstract

Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF.

Published
2023

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