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According to the World Health Organization, women's breast cancer is among the most common cancers with 7.8 million diagnosed cases during 2016–2020 and encompasses 15 % of all female cancer-related mortalities. These mortality events from triple-negative breast cancer are a significant health issue worldwide calling for a continuous search of bioactive compounds for better cancer treatments. Historically, plants are important sources for identifying such new bioactive chemicals for treatments. Here we use high-throughput screening and mass spectrometry analyses of extracts from 100 plant species collected in Chinese ancient forests to detect novel bioactive breast cancer phytochemicals. First, to study the effects on viability of the plant extracts, we used a MTT and CCK-8 cytotoxicity assay employing triple-negative breast cancer (TNBC) MDA-MB-231 and normal epithelial MCF-10A cell lines and cell cycle arrest to estimate apoptosis using flow cytometry for the most potent three speices. Based on these analyses, the final most potent extracts were from the Amur honeysuckle (Lonicera maackii) wood/root bark and Nigaki (Picrasma quassioides) wood/root bark. Then, 5 × 106 MDA-MB-231 cells were injected subcutaneously into the right hind leg of nude mice and a tumour was allowed to grow before treatment for seven days. Subsequently, the four exposed groups received gavage extracts from Amur honeysuckle and Nigaki (Amur honeysuckle wood distilled water, Amur honeysuckle root bark ethanol, Nigaki wood ethanol or Nigaki root bark distilled water/ethanol (1:1) extracts) in phosphate-buffered saline (PBS), while the control group received only PBS. The tumour weight of treated nude mice was reduced significantly by 60.5 % within 2 weeks, while on average killing 70 % of the MDA-MB-231 breast cancer cells after 48 h treatment (MTT test). In addition, screening of target genes using the Swiss Target Prediction, STITCH, STRING and NCBI-gene database showed that the four plant extracts possess desirable activity towards several known breast cancer genes. This reflects that the extracts may kill MBD-MB-231 breast cancer cells. This is the first screening of plant extracts with high efficiency in 2 decades, showing promising results for future development of novel cancer treatments.

Public participation is crucial for policy-making and can contribute to strengthening democracies and decision-making. Public participation can help to address sustainability challenges and plays a key role in attaining the Sustainable Development Goals (SDGs). While the SDGs are policy concepts, there has been limited research conducted on how the public perceives the SDGs. Public participation in scientific research has been carried out through citizen science (CS). This paper analyzes the public's perception of the SDGs through CS and how the public can participate in their implementation. The paper uses the OSDG community platform, a citizen science platform with >2000 participants, to analyze public perception of the SDGs. A set of 40,062 excerpts of text (v2023-01-01), a topic modeling and agreement scores by using CorTexT Manager software, was analyzed. The results show that some SDGs, e.g. health (SDG3) or life below water (SDG14), have higher levels of agreement from the public, whilst for other SDGs the public disagree on their perception, (e.g. zero hunger). The paper shows that issues affecting citizens' daily lives (e.g. in People related goals) tend to have a higher level of agreement among volunteers, while economic issues and directives have greater discrepancies. The results provide an overview of the differences in public perception on the SDGs and their implementation. The misperceptions regarding the SDGs should be reduced to achieve a better implementation, improve public participation, and help policy-making processes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The United Nations Millennium Development Goals initiative, designed to meet the needs of the world's poorest, ended in 2015. The purpose of this article is to describe the progress made through the Millennium Development Goals and the additional work needed to address vulnerable populations worldwide, especially women and children. A description of the subsequent Sustainable Development Goals, enacted to address the root causes of poverty and the universal need for development for all people, is provided., (Copyright © 2017 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.)