20 results on '"Gimeno, J"'
Search Results
2. Mononuclear Ru/Os Compounds with Cyclic C5–C6 Ligands (Except Compounds containing monohapto Ligands)
- Author
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Gimeno, J., primary, Cadierno, V., additional, and Crochet, P., additional
- Published
- 2007
- Full Text
- View/download PDF
3. Mononuclear Ru/Os Compounds with η1 and C5–C6 Ligands
- Author
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Gimeno, J., primary and Cadierno, V., additional
- Published
- 2007
- Full Text
- View/download PDF
4. Water storage in soils during the fallow: prediction of the effects of rainfall pattern and soil conditions in the Ebro valley of Spain
- Author
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Austin, Roger B., Playán Jubillar, Enrique, Gimeno, J., Austin, Roger B., Playán Jubillar, Enrique, and Gimeno, J.
- Abstract
Fallowing remains a feature of dryland cereal agriculture in some low rainfall areas of central and northern Spain. To complement the limited number of measurements of water stored during the fallow, we developed a physically based simulation model to estimate the effects of variations in rainfall, soil characteristics and surface conditions on water storage in the profile. Mean annual rainfall in the locations investigated varied from ca. 300–500 mm and the mean amount of water stored during the last year of a bare fallow ranged from 1–48 mm, depending on soil and climate. The standard deviations of these amounts, each based on 25 simulations, varied from 11–39 mm. Rainfall in the last 3 months of the fallow was the principal cause of this year to year variation in storage. Surface stoniness and crop residues decreased evaporation from the soil and increased storage: there was very little drainage. These findings are consistent with measured water storage in soils in this part of Spain, and other areas of the world with similar climates and agricultural practices. Based on barley yield/rainfall regressions for data from a dry area in the Ebro valley, we estimated that the annual yields from a crop–fallow system would be 15% greater than those from annual cropping. For fallowing to be economic, yields per crop would need to be about twice those obtained with annual cropping. There may be yield benefits from fallowing apart from those resulting from extra water storage in the soil. Unless such benefits can be demonstrated, fallowing would appear to be uneconomical in this area of Spain.
- Published
- 1998
5. Clinical and molecular spectrum of v-lesion.
- Author
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Buxeda A, Crespo M, Chamoun B, Gimeno J, Torres IB, Redondo-Pachón D, Riera M, Burballa C, Pascual J, Mengel M, Adam BA, and Pérez-Sáez MJ
- Abstract
Isolated v-lesion presents diagnostic stratification and clinical challenges. We characterized allograft outcomes for this entity based on posttransplant time (early: ≤1 month vs late: >1 month) and compared its molecular phenotype with other v+ rejection forms. Using the NanoString B-HOT panel, we analyzed 92 archival formalin-fixed paraffin-embedded tissue kidney biopsies from 3 centers: isolated v-lesion (n = 23), antibody-mediated rejection (ABMR) v+ (n = 26), T cell-mediated rejection (TCMR) v+ (n = 10), mixed rejection v+ (n = 23), and normal tissue (n = 10). Six gene sets (ABMR, DSAST, ENDAT, TCMR, early/acute injury, late injury) were assessed. Early isolated v-lesions had the poorest 1-year death-censored graft survival compared with late isolated v-lesions or other rejections (P = .034). Gene set analysis showed lower TCMR-related gene expression in isolated v+ groups than TCMR and mixed rejection (P < .001). Both early- and late isolated v-lesions had lower ABMR-related gene expression than ABMR, mixed rejection, and TCMR (P ≤ .022). Late isolated v-lesions showed reduced DSAST and ENDAT gene expression versus ABMR (P ≤ .046) and decreased early/acute injury gene expression than early isolated v+, ABMR, TCMR, and mixed rejection (P ≤ .026). In conclusion, isolated v-lesions exhibit distinct gene expression patterns versus other rejection v+ forms. Early isolated v+ is associated with poorer prognosis and increased early/acute injury gene expression than late isolated v+, suggesting distinct etiologies., (Copyright © 2024 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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6. Corrigendum to "Microvascular inflammation in the absence of human leukocyte antigen-donor-specific antibody and C4d: An orphan category in Banff classification with cytotoxic T and natural killer cell infiltration" [American Journal of Transplantation 23 (2023) 464-474].
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Buxeda A, Llinàs-Mallol L, Gimeno J, Redondo-Pachón D, Arias-Cabrales C, Burballa C, Puche A, López-Botet M, Yélamos J, Vilches C, Naesens M, Pérez-Sáez MJ, Pascual J, and Crespo M
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- 2024
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7. Microvascular inflammation in the absence of human leukocyte antigen-donor-specific antibody and C4d: An orphan category in Banff classification with cytotoxic T and natural killer cell infiltration.
- Author
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Buxeda A, Llinàs-Mallol L, Gimeno J, Redondo-Pachón D, Arias-Cabrales C, Burballa C, Puche A, López-Botet M, Yélamos J, Vilches C, Naesens M, Pérez-Sáez MJ, Pascual J, and Crespo M
- Subjects
- Humans, Kidney pathology, Antibodies, Inflammation pathology, Killer Cells, Natural, HLA Antigens, Graft Rejection pathology, Kidney Transplantation adverse effects
- Abstract
Isolated microvascular inflammation (iMVI) without HLA donor-specific antibodies or C4d deposition in peritubular capillaries remains an enigmatic phenotype that cannot be categorized as antibody-mediated rejection (ABMR) in recent Banff classifications. We included 221 kidney transplant recipients with biopsies with ABMR (n = 73), iMVI (n = 32), and normal (n = 116) diagnoses. We compared peripheral blood leukocyte distribution by flow cytometry and inflammatory infiltrates in kidney transplant biopsies among groups. Flow cytometry showed fewer lymphocytes and total, CD4
+ , and CD8+ peripheral T cells in iMVI compared with ABMR and normal cases. ABMR and iMVI had fewer total natural Killer (NK) cells but more NKG2A+ NK cells. Immunohistochemistry indicated that ABMR and iMVI had greater CD3+ and CD68+ glomerular infiltration than normal biopsies, whereas CD8+ and TIA1+ cells showed only increased iMVI, suggesting they are cytotoxic T cells. Peritubular capillaries displayed more CD3+ , CD56+ , TIA1+ , and CD68+ cells in both ABMR and iMVI. In contrast, iMVI had less plasma cell infiltration in peritubular capillaries and interstitial aggregates than ABMR. iMVI displayed decreased circulating T and NK cells mirrored by T cell and NK cell infiltration in the renal allograft, similar to ABMR. However, the lesser plasma cell infiltration in iMVI may suggest an antibody-independent underlying stimulus., (Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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8. Erratum to "Renal graft survival according to Banff 2013 classification in indication biopsies".
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Arias-Cabrales C, Redondo-Pachón D, Pérez-Sáez MJ, Gimeno J, Sánchez-Güerri I, Bermejo S, Sierra A, Burballa C, Mir M, Crespo M, and Pascual J
- Published
- 2017
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9. Renal graft survival according to Banff 2013 classification in indication biopsies.
- Author
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Arias-Cabrales C, Redondo-Pachón D, Pérez-Sáez MJ, Gimeno J, Sánchez-Güerri I, Bermejo S, Sierra A, Burballa C, Mir M, Crespo M, and Pascual J
- Subjects
- Adult, Female, Graft Rejection, Humans, Male, Middle Aged, Retrospective Studies, Biopsy, Graft Survival, Kidney pathology, Kidney Transplantation
- Abstract
Introduction: The impact of acute rejection in kidney graft survival is well known, but the prognosis of other diagnoses is uncertain. We evaluated the frequency and impact on graft survival of different diagnostic categories according to the Banff 2013 classification in a cohort of renal transplant recipients., Material and Methods: Retrospective study of 495 renal biopsies by indication in 322 patients from 1990-2014. Two independent observers reviewed the histological reports, reclassifying according to the Banff 2013 classification., Results: Of 495 biopsies, 28 (5.7%) were not diagnostic. Of the remaining 467, 10.3% were «normal» (category 1), 19.6% antibody-mediated changes (category 2), 5.9% «borderline» changes (category 3), 8.7% T-cell-mediated rejection (category 4), 23.4% interstitial fibrosis/tubular atrophy (IFTA) (category 5) and 26.5% with other diagnoses (category 6). As time after transplantation increases, diagnoses of categories 1, 3 and 4 decrease, while categories 5 and 2 increase. Worse graft survival with category 2 diagnosis was observed (45% at 7.5 years, HR 4.29 graft loss [95% CI, 2.39-7.73]; P≤.001, compared to category 1). Grafts with «unfavourable histology» (chronic antibody-mediated rejection, moderate-severe IFTA) presented worse survival that grafts with «favourable histology» (normal, acute tubular necrosis, mild IFTA)., Conclusions: The Banff 2013 classification facilitates a histological diagnosis in 95% of indication biopsies. While diagnostic category 6 is the most common, a change in the predominant histopathology was observed according to time elapsed since transplantation. Antibody-mediated changes are associated with worse graft survival., (Copyright © 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2016
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10. Predictive factors for non-diabetic nephropathy in diabetic patients. The utility of renal biopsy.
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Bermejo S, Soler MJ, Gimeno J, Barrios C, Rodríguez E, Mojal S, and Pascual J
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- Aged, Creatinine blood, Diabetic Nephropathies complications, Diabetic Retinopathy complications, Female, Glomerulonephritis, IGA complications, Humans, Male, Middle Aged, Proteinuria complications, Retrospective Studies, Biopsy, Diabetes Mellitus, Type 2 complications, Diabetic Nephropathies diagnosis, Glomerulonephritis, IGA diagnosis, Kidney physiopathology
- Abstract
Background and Objectives: Diabetic renal lesions can only be diagnosed by kidney biopsy. These biopsies have a high prevalence of non-diabetic lesions. The aims of the study were to determine the predictability of non-diabetic nephropathy (NDN) in diabetics and study differences in survival and renal prognosis. In addition, we evaluated histological lesions and the effect of proteinuria on survival and renal prognosis in patients with diabetic nephropathy (DN)., Material and Methods: A descriptive, retrospective study of kidney biopsies of diabetics between 1990 and 2013 in our centre., Results: 110 patients were included in the study: 87 men (79%), mean age 62 years (50-74), mean serum creatinine 2.6mg/dl (0.9-4.3) and proteinuria 3.5g/24hours (0.5-6.5). 61.8% showed NDN, 34.5% showed DN and 3,6% showed DN+NDN. The most common NDN was IgA nephropathy (13,2%). In the multivariate analysis, creatinine (OR: 1.48, 1.011-2.172, p=0.044), proteinuria/24hours (OR: 0.813, 0.679-0.974, p=0.025), duration of diabetes (OR: 0.992, 0.987-0.998, p=0.004), age (OR: 1.068, 95% CI: 1.010-1.129, p=0.022), and diabetic retinopathy (OR: 0.23, 0.066-0.808, p=0.022) were independently associated with NDN. We did not find any differences in survival or renal prognosis. Concerning patients with DN, increased nodular mesangial expansion (p=0.02) and worse renal prognosis (p=0.004) were observed in nephrotic proteinuria as compared to non-nephrotic proteinuria. We did not find differences in patient survival., Conclusions: The most common cause of NDN was IgA nephropathy. Higher creatinine levels, shorter duration of diabetes, absence of diabetic retinopathy, lower proteinuria, and older age were risk factors for NDN. Patients with DN and nephrotic-range proteinuria had worse renal prognosis., (Copyright © 2016 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved.)
- Published
- 2016
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11. Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival.
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Redondo-Pachón D, Pascual J, Pérez-Sáez MJ, García C, Hernández JJ, Gimeno J, Mir M, and Crespo M
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- Adult, Aged, Allografts immunology, Female, Graft Survival immunology, HLA-DP Antigens immunology, Histocompatibility Testing, Humans, Isoantibodies blood, Kidney immunology, Male, Middle Aged, Transplantation, Homologous, Graft Rejection immunology, HLA-DP Antigens metabolism, Kidney Transplantation
- Abstract
The influence of antibodies against HLA-DP antigens detected with solid-phase assays on graft survival after kidney transplantation (KT) is uncertain. We evaluated with Luminex® the prevalence of pre- and posttransplant DP antibodies in 440 KT patients and their impact on graft survival. For 291 patients with available pretransplant samples, DP antibodies were present in 39.7% KT with pretransplant HLA antibodies and 47.7% with DSA. Graft survival of KT with pretransplant class-II DSA was worse than with non-DSA (p=0.01). DP antibodies did not influence graft survival. Of 346 patients monitored post-KT, 17.1% had HLA class-II antibodies, 56% with DP antibodies. Class-II DSA was detected in 39%, 60.9% of them had DP antibodies. Graft survival was worse in patients with class-II DSA (p=0.022). DP antibodies did not change these results. The presence of isolated DP antibodies was a rare event both pre- and posttransplantation (1.03 and 0.86%). The presence of pretransplant and posttransplant DSA is associated with a negative impact on graft survival. However, the presence of DP antibodies does not modify this impact significantly., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
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12. Assessment of ALK status by FISH on 1000 Spanish non-small cell lung cancer patients.
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Vidal J, Clavé S, de Muga S, González I, Pijuan L, Gimeno J, Remón J, Reguart N, Viñolas N, Gironés R, Bernet L, Majem M, Bosch-Barrera J, Porta R, Alonso N, Palmero R, Taus A, Albanell J, Espinet B, Salido M, and Arriola E
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- Anaplastic Lymphoma Kinase, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung pathology, Female, Gene Rearrangement, Humans, In Situ Hybridization, Fluorescence methods, Lung Neoplasms genetics, Lung Neoplasms pathology, Male, Middle Aged, Retrospective Studies, Carcinoma, Non-Small-Cell Lung enzymology, Lung Neoplasms enzymology, Receptor Protein-Tyrosine Kinases genetics
- Abstract
Introduction: Patients with non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) rearrangement selectively respond to ALK inhibitors. Thus, identification of ALK rearrangements has become a standard diagnostic test in advanced NSCLC patients. Our institution has been a referral center in Spain for ALK determination by Fluorescent in situ hybridization (FISH). The aim of our study was to assess the feasibility and the FISH patterns of the ALK gene and to evaluate the clinical and pathological features of patients with ALK alterations., Methods: Between 2010 and 2014, 1092 samples were evaluated for ALK using FISH technique (927 histological samples, 165 cytological samples). Correlation with available clinical-pathological information was assessed., Results: ALK rearrangement was found in 35 patients (3.2%). Cytological samples (using either direct smears or cell blocks), were more frequently non-assessable than histological samples (69% versus 89%, respectively) (p < 0.001). Within the ALK-rearranged cases the majority were female, non-smokers, and stage IV., Conclusions: Although assessable in cytological samples, biopsies are preferred when available for ALK evaluation by FISH. The ALK translocation prevalence and the associated clinico-pathological features in Spanish NSCLC patients are similar to those previously reported.
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- 2014
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13. Epithelial to mesenchymal transition markers are associated with an increased metastatic risk in primary cutaneous squamous cell carcinomas but are attenuated in lymph node metastases.
- Author
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Toll A, Masferrer E, Hernández-Ruiz ME, Ferrandiz-Pulido C, Yébenes M, Jaka A, Tuneu A, Jucglà A, Gimeno J, Baró T, Casado B, Gandarillas A, Costa I, Mojal S, Peña R, de Herreros AG, García-Patos V, Pujol RM, and Hernández-Muñoz I
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- Antigens, CD, Cadherins metabolism, Down-Regulation, Homeodomain Proteins metabolism, Humans, Immunohistochemistry, Membrane Glycoproteins metabolism, Nuclear Proteins metabolism, Phenotype, Retrospective Studies, Risk, Snail Family Transcription Factors, Transcription Factors metabolism, Twist-Related Protein 1 metabolism, Vimentin metabolism, Zinc Finger E-box-Binding Homeobox 1, beta Catenin metabolism, Biomarkers, Tumor metabolism, Carcinoma, Squamous Cell metabolism, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Lymphatic Metastasis, Skin Neoplasms metabolism
- Abstract
Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epithelial to mesenchymal transition (EMT) is a process involving loss of intercellular adhesion, acquisition of a mesenchymal phenotype and enhanced migratory potential; epithelial markers, such as E-cadherin, are down-regulated and mesenchymal proteins (Vimentin), increased., Objective: To investigate the expression of EMT markers in metastatic SCC (MSCC) and their corresponding metastases, and to correlate them with clinico-pathological factors associated with an increased risk of metastasis., Methods: We performed a retrospective study that included 146 cSCC samples (51 primary non-metastatic, 56 primary metastatic, 39 lymphatic metastases). Immunohistochemistry for E-cadherin, Vimentin, Snail, beta-catenin, Twist, Zeb1 and Podoplanin was performed., Results: Loss of membranous E-cadherin was observed in 77% cSCCs, with no differences between MSCC and non-MSCC. Among the transcriptional factors controlling EMT, no significant Snail1 expression was detected. Twist, Zeb1, Vimentin, beta-catenin and Podoplanin were significantly overexpressed in MSCCs. Twist ectopic expression in SCC13 cells induced Zeb1, Vimentin and Podoplanin expression and E-cadherin delocalization. These changes resulted in a scattered migration pattern in vitro. Expression of EMT markers was decreased in the metastases when compared with the corresponding primary tumors., Conclusion: These results suggest that a partial EMT, characterized by the expression of Twist but without a total E-cadherin depletion, is involved in the acquisition of invasive traits by cSCC, but the process is downregulated in lymph node metastases., (Copyright © 2013 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
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14. [Nutrient intake and eating habits in hemodialysis patients: comparison with a model based on mediterranean diet].
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Lou LM, Campos B, Gimeno JA, Caverní A, and Boned B
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- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Models, Theoretical, Diet, Mediterranean, Dietary Proteins, Energy Intake, Feeding Behavior, Renal Dialysis
- Abstract
Objectives: Inadequate nutrient intake seems to be one of the most important cause of malnutrition in hemodialysis patients. The purpose of this study was to analyse their nutrient intake and eating habits, comparing food groups' intake with standard Mediterranean diet values (Healthy Diet Guide 2004, Nutrition Community Spanish Society)., Material and Methods: There were 28 stable hemodialysis (HD) patients, 15 males and 13 females, mean age 62,9 +/- 16 years. Dietary evaluation was based on 7-day dietary recalls conducted by a single observer. We compare nutrients intake with recommended hemodialysis intake and we contrast food groups consumption with the theoretical ideal based on Mediterranean diet., Results: The protein intake was 1,33 +/- 0,2 g/kg/day and the energy intake 29,5 +/- 2,1 kcal/kg/day. Carbohydrates accounted 43,1% of energy intake, proteins 19% and lipids 37,9% (55,5% monounsaturated fatty acids, 16,4% polyunsaturated fatty acids and 28,1% saturated fatty acids). Complex carbohydrates (potatoes, cereals, vegetables, fruits) and olive oil consumption was lower than that recommended to the Spanish healthy population and to the chronic hemodialysis patients. The animal protein intake (meat, fish, eggs) was correct, although excessive in red and processed meats. Results: Potatoes and cereals recommended frequency (RF) 4-6 portions/day, HD patients frequency (HDF) 4,1 portions/day; vegetables RF > 2 portions/day, HDF 1,2; fruits RF > 3 portions/day, HDF 1,3; olive oil RF 3-6 portions/day, HDF 1,5; Fish RF 3-4 portions/week, HDF 4,2; White meat RF 3-4 portions/week, HDF 1,5; Poultry RF 3-4 portions/week, HDF 2,3; Eggs RF 3-4 portions/week, HDF 3,6; Pulses RF 3-4 portions/week, HDF 1,7; Nuts RF 3-7 portions/week, HDF 0; Red meat RF occasionally, HDF 4,8 portions/week; Processed meats RF occasionally, HDF 4,6 portions/week; Sweets, snacks, soft drinks RF occasionally, HDF 1,7 portions/week; Butter, margarine, processed bakery products, biscuits RF occasionally , HDF 0,5 portions/week., Conclusions: Nutritional abnormalities are frequently found even in apparently stable patients on chronic hemodialysis. Caloric rather than protein undernutrition is the major abnormality. Inadequate caloric intake (< 35 kcal/kg/day) can lead to a negative nitrogen balance. Their eating habits are healthy and natural, but there is a deficit in slowly absorbed carbohydrates and olive oil intake (with caloric intake reduction), and an excessive consumption of red and processed meats (with saturated fats increase). The individual correction of these dietary patterns could reduce the saturated fats and increase the energy intake, obtaining a balanced diet integrated into our geographic region and culture.
- Published
- 2007
15. Characteristic overpressure-impulse-distance curves for vapour cloud explosions using the TNO Multi-Energy model.
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Díaz Alonso F, González Ferradás E, Sánchez Pérez JF, Miñana Aznar A, Ruiz Gimeno J, and Martínez Alonso J
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- Accidents, Occupational, Humans, Pressure, Explosions, Models, Theoretical
- Abstract
A number of models have been proposed to calculate overpressure and impulse from accidental industrial explosions. When the blast is produced by ignition of a vapour cloud, the TNO Multi-Energy model is widely used. From the curves given by this model, data are fitted to obtain equations showing the relationship between overpressure, impulse and distance. These equations, referred herein as characteristic curves, can be fitted by means of power equations, which depend on explosion energy and charge strength. Characteristic curves allow the determination of overpressure and impulse at each distance.
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- 2006
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16. [Concordance of Cockcroft Gault formula and MDRD formula to estimate glomerular filtration rate in patients with diabetes type 2].
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Gimeno JA, Lou LM, Molinero E, Campos B, Boned B, and Sánchez Vañó R
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- Aged, Female, Humans, Male, Middle Aged, Models, Biological, Diabetes Mellitus, Type 2 physiopathology, Glomerular Filtration Rate
- Published
- 2006
17. [Comparison of clinical arterial pressure, home-arterial pressure measurement, and ambulatory arterial pressure monitoring in patients with type II diabetes mellitus and diabetic nephropathy].
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Lou LM, Gimeno JA, Gómez Sánchez R, Labrador T, Beguer P, Lou MT, Boned B, and Aguilar E
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- Aged, Albuminuria etiology, Antihypertensive Agents therapeutic use, Blood Pressure Determination statistics & numerical data, Blood Pressure Monitoring, Ambulatory, Cardiovascular Diseases complications, Cardiovascular Diseases physiopathology, Circadian Rhythm, Creatinine blood, Diabetic Angiopathies complications, Diabetic Angiopathies physiopathology, Diabetic Nephropathies blood, Diabetic Nephropathies complications, Diabetic Nephropathies urine, Female, Glycated Hemoglobin analysis, Home Nursing, Humans, Hyperlipidemias complications, Hyperlipidemias drug therapy, Hypertension etiology, Hypertension physiopathology, Hypolipidemic Agents therapeutic use, Male, Middle Aged, Predictive Value of Tests, Proteinuria etiology, Self Care, Ventricular Function, Left, Blood Pressure, Blood Pressure Determination methods, Diabetes Mellitus, Type 2 physiopathology, Diabetic Nephropathies physiopathology, Hypertension diagnosis
- Abstract
Background: Hypertension is common in type 2 diabetes with diabetic nephropathy, and increases the risk of cardiovascular complications and renal chronic insufficiency. The aim of our evaluation in these patients was: a) to study the correlation between office blood pressure (BP), self-monitored (SMBP) and 24-hour ambulatory blood pressure monitoring (ABPM). b) To study the correlation between these methods and cardiovascular and renal complications., Methods: We studied 60 patients (mean age 66.7 +/- 9 years, mean duration of diabetes 11.3 +/- 7 years) with arterial hypertension, type 2 diabetes and diabetic nephropathy. Macroangiopathy and echocardiography were recorded. We measured, SMBP and ABPM without modifying the antihypertensive treatment. The white coat phenomenon (WCP) was determined and patients were classified as dippers or non dippers according to their blood pressure diurnal rhythm., Results: Mean glycated haemoglobin was 7.8% and mean serum creatinine 1.2 +/- 0.5 mg/dl, 30% of patients had proteinuria and 70% microalbuminuria The mean number of antihypertensive drugs was 2.2 +/- 1. The mean BP was: Office BP: 158.2 +/- 24/85.3 +/- 9 mmHg, pulse pressure (PP) 72.9 +/- 21 mmHg; SMBP: 145.4 +/- 18/77.5 +/- 7 mmHg, PP 67.9 +/- 18 mmHg and BP in the early morning 150.2 +/- 20/79.9 +/- 9 mmHg; ABPM: diurnal mean 138.9 +/- 15/74.1 +/- 6 mmHg, PP 64.8 +/- 15 mmHg and BP in the early morning 146.5 +/- 16/78.5 +/- 7 mmHg. The three techniques showed a good correlation and WCP was detected in 46.7% of patients with SMBP and in 56.7% with ABPM. We found no correlation between BP and macroangiopathy, but an increase of systolic BP in SMBP and ABPM in proteinuric patients were found and correlation between mass left ventricular index (MLVI) and PP in office and systolic BP and PP in SMBP and ABPM was significant. 70% of patients were non dippers, with a higher MLVI., Conclusions: Decreases in BP in type 2 diabetes with diabetic nephropathy are difficult of maintain despite combinations of different antihypertensive drugs. These patients present an important WCP and worse prognosis data, such as elevation of systolic BP, increased PP, poor night BP fall and a BP rise in the early morning. Also, we can't reduced the BP during 24 hours in an important number of patients. These characteristics can be detected by combining the office BP measurement, SMBP and ABPM. The alternative possibility would be lifestyle modification, appropriate drug combinations and to start treatment at lower levels than those currently used as thresholds (the guidelines for antihypertensive treatment have been drastically shifted in this direction over the past years).
- Published
- 2002
18. [Characteristics of acute renal failure in elderly patients admitted to a small town hospital].
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Lou LM, Boned B, Gimeno JA, Beguer P, Cruz A, Telmo S, Lou MT, and Gómez Sánchez R
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- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Spain epidemiology, Survival Analysis, Treatment Outcome, Acute Kidney Injury complications, Acute Kidney Injury epidemiology, Hospitals, Municipal statistics & numerical data
- Abstract
We studied the features of acute renal failure (ARF) in elderly patients treated in a hospital, without an intensive care unit, to identify etiological factors and establish adequate preventive measures and treatment. During twelve consecutive months we studied prospectively 99 patients with ARF diagnosed by conventional criteria, an incidence of 1,238 cases per million per year. ARF affected 1.78% of patients admitted to hospital. We analyzed age, sex, serum creatinine, diuresis, etiology, type of ARF, preexisting chronic diseases, treatment, complications and outcome. Preexisting chronic diseases were common, the most frequent being hypertension (54%) and diabetes (39%). Previous treatments for cardiovascular diseases were frequent (angiotensin-renin system blockade 35.4%, diuretics 50.5%). 79% of ARF arose in hospital, 21% outside hospital. ARF was pre-renal in 60%, renal in 31% and post-renal in 9%. 34.7% were caused by volume depletion, 23.4% by low cardiac output and 23.4% by infection. 44.4% of ARF patients had oliguria or anuria latrogenic factors contributed to the ethiology of ARF in 35.3% of patients. Hospital stay was doubled by ARF the presence of ARF and the mortality was 36.4%. The rate was higher in ARF arising in hospital than in ARF acquired before admission. Factors that had a significant influence on the mortality rate were comorbid conditions, oliguroanuria, ARF of renal origin and serum albumin. We conclude that ARF has a high incidence, morbidity and mortality in this elderly population. Volume depletion, associated cardiovascular pathology and pharmacological treatment are important etiological factors in those with ARF outside hospital. Adequate treatment of ARF and avoidance of nephrotoxic medications are necessary in hospital.
- Published
- 2002
19. [Evaluation of food intake in hemodialysis using a food consumption and appetite questionnaire].
- Author
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Lou LM, Gimeno JA, Paúl J, Sanz París A, Gutiérrez Dalmau A, Gómez Sánchez R, Pérez Pérez J, and Boned B
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- Aged, Aged, 80 and over, Cross-Sectional Studies, Dietary Proteins, Feeding Behavior, Female, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Male, Middle Aged, Predictive Value of Tests, Protein-Energy Malnutrition diagnosis, ROC Curve, Sensitivity and Specificity, Appetite, Diet Records, Energy Intake, Protein-Energy Malnutrition etiology, Renal Dialysis adverse effects, Surveys and Questionnaires
- Abstract
Protein calorie malnutrition is a common complication in chronic hemodialysis patients (CHP). Although many factors could promote malnutrition, inadequate nutrient intake seems to be one of the most important. An Appetite and Diet Assessment Questionnaire (ADAQ) was developed, and we have performed a cross-sectional study in 44 CHP to investigate its capacity to predict an inadequate intake. Dietary evaluation was based on a diet diary-assisted recalls (DDAR). On the other hand, the validity of PCR and the differences in the DDAR and ADAQ between the days of dialysis and the days without dialysis were studied. The predictive value of inadequate intake of the ADAQ and the PCR were analysed with the ROC curve. The protein intake was 1.3 +/- 0.3 g/kg/day and the energy intake 29.2 +/- 0.6 kcal/kg/day. The average PCR was 1.14 +/- 0.3. The ROC curve to predict inadequate intake from the ADAQ shows an area under the curve of 0.84 for the protein intake and 0.73 for the energy intake. A cut-off ponit of 18 gives a sensitivity of 100% and a specificity of 44% for the detection of poor protein intake (< 1.2 g/kg/day) and of 74% and 56% for the detection of poor energy intake (< 30 kcal/kg/day). The ROC curve to predict inadequate protein intake from the PCR obtains an area under the curve of 0.81. The cut-off 1.06 gives the best sensitivity (100%) and specificity (64%) for the detection of insufficient protein intake. We did not find any significant difference in the DDAR or in the ADAQ between the days of dialysis and the days without dialysis. Despite the subjective interpretation, the relationship between ADAQ and protein-energy intakes analysed by DDAR was highly significant. The questionnaire is simple and can therefore be used as a screening rest to detect and correct alterations in the diet which could otherwise lead to malnutrition. The determination of PCR gives a good sensitivity and specificity for the detection of poor protein intake, although the results are modified in anabolic or catabolic states which can clinically go undetected. We do not register differences in diet between the days of dialysis and the days without dialysis.
- Published
- 2002
20. Atypical angina.
- Author
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Gimeno JR, Iñigo LA, López-Palop R, and Valdés Chavarri M
- Subjects
- Angina Pectoris diagnosis, Coronary Angiography, Diagnosis, Differential, Echocardiography, Transesophageal, Female, Heart Atria pathology, Heart Neoplasms surgery, Humans, Magnetic Resonance Imaging, Middle Aged, Myxoma surgery, Heart Neoplasms diagnosis, Myxoma diagnosis
- Published
- 2000
- Full Text
- View/download PDF
Catalog
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