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2 results on '"G. Nishioka"'

1. Repetitive transcranial magnetic stimulation induces kf-1 expression in the rat brain.

Author

Kudo K, Yamada M, Takahashi K, Nishioka G, Tanaka S, Hashiguchi T, Fukuzako H, Takigawa M, Higuchi T, Momose K, Kamijima K, and Yamada M

Subjects
Animals, Antidepressive Agents pharmacology, Blotting, Northern, DNA Primers, Haloperidol pharmacology, Male, Nerve Tissue Proteins genetics, Neuronal Plasticity drug effects, Oligonucleotide Array Sequence Analysis, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Frontal Lobe metabolism, Gene Expression, Hippocampus metabolism, Nerve Tissue Proteins metabolism, Transcranial Magnetic Stimulation
Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive approach used for stimulating the brain, and has proven effective in the treatment of depression, however the mechanism of its antidepressant action is unknown. Recently, we have reported the induction of kf-1 in rat frontal cortex and hippocampus after chronic antidepressant treatment and repeated electroconvulsive treatment (ECT). In this study, we demonstrated the induction of kf-1 after rTMS in the rat frontal cortex and hippocampus, but not in hypothalamus. Our data suggest that kf-1 may be a common functional molecule that is increased after antidepressant treatment, ECT and rTMS. In conclusion, it is proposed that induction of kf-1 may be associated with the treatment induced adaptive neural plasticity in the brain, which is a long-term target for their antidepressant action.

Published
2005
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2. Identification of a novel gene with RING-H2 finger motif induced after chronic antidepressant treatment in rat brain.

Author

Yamada M, Yamada M, Yamazaki S, Takahashi K, Nishioka G, Kudo K, Ozawa H, Yamada S, Kiuchi Y, Kamijima K, Higuchi T, and Momose K

Subjects
Amino Acid Sequence, Animals, Base Sequence, Blotting, Northern, Brain metabolism, Cerebral Cortex drug effects, Cerebral Cortex metabolism, Cloning, Molecular, Conserved Sequence, DNA, Complementary metabolism, Expressed Sequence Tags, Fluorescent Dyes metabolism, Hippocampus drug effects, Hippocampus metabolism, Humans, Hypothalamus drug effects, Hypothalamus metabolism, Male, Mice, Molecular Sequence Data, Nerve Tissue Proteins genetics, Nerve Tissue Proteins metabolism, Oligonucleotide Array Sequence Analysis, Protein Structure, Tertiary, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Selective Serotonin Reuptake Inhibitors pharmacology, Sertraline pharmacology, Tissue Distribution, Ubiquitin-Protein Ligases, Antidepressive Agents pharmacology, Brain drug effects, Nerve Tissue Proteins biosynthesis
Abstract

Previously, we have identified 200 cDNA fragments as antidepressant related genes/ESTs. In this study, using these cDNAs, we developed our original cDNA microarray for rapid secondary screening of candidate genes as the novel therapeutic targets. With this microarray, we found that the expression of a novel gene, ADRG34, was significantly increased in rat hippocampus which had been chronically treated with a selective serotonin reuptake inhibitor antidepressant, sertraline. RT-PCR analysis also demonstrated the induction of ADRG34 at mRNA levels in rat hippocampus and the frontal cortex. This cDNA encoded 685 amino acid residues containing a RING-H2 finger motif at the carboxy-terminal. Sequence analysis of ADRG34 with the EMBL/GenBank database showed significant homology to mouse and human kf-1 gene. Our data suggest that ADRG34, a possible rat homologue of kf-1, may be one of the common functional molecules induced after chronic antidepressant treatment., (Copyright 2000 Academic Press.)

Published
2000
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