Author: "Freeman, P." / Publisher: elsevier - Searchworks@Jio Institute Digital Library Search Results

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521 results on '"Freeman, P."'

1. Skin and Digital–The 2024 Narrative

Author: Dominique du Crest, MBE, Monisha Madhumita, MD, Wendemagegn Enbiale, MD, MPH, PhD, Alexander Zink, MD, MPH, PhD, Art Papier, MD, Gaone Matewa, BBA, Harvey Castro, MD, MBA, Hector Perandones, MD, Josef De Guzman, OD-OPS, Misha Rosenbach, MD, Tu-Anh Duong, MD, PhD, Yu-Chuan Jack Li, MD, PhD, Hugues Cartier, MD, Benjamin Ascher, MD, Sebastien Garson, MD, Alessandra Haddad, MD, PhD, Daniel Z. Liu, MD, Diala Haykal, MD, Jane Yoo, MD, MPP, Nav Paul, MBBS, MRCP, Tracy Cohen Sayag, Mfin, Merete Hædersdal, MD, PhD, DMSc, Esther Freeman, MD, PhD, and Lilit Garibyan, MD, PhD
Subjects: Computer applications to medicine. Medical informatics, R858-859.7
Abstract: The global burden of skin diseases affects over 3 billion individuals, posing important public health challenges worldwide, with profound impacts in both high-income and low-income and middle-income countries. These challenges are exacerbated by widespread disparities in access to dermatologic care and the prevalence of misinformation. This article, derived from the Skin and Digital Summit at the International Master Course on Aging Science critically evaluates how digital technologies such as artificial intelligence, teledermatology, and large language models can bridge these access gaps. It explores practical applications and case studies demonstrating the impact of these technologies in various settings, with a particular focus on adapting solutions to meet the diverse needs of low-income and middle-income countries. In addition, the narrative highlights the ongoing conversation within the dermatologic community about the role of digital advances in health care, emphasizing that this discussion is dynamic and the one that is continuously evolving. Dermatologists play an essential role in this transition, integrating digital tools into mainstream care to complement a patient-centered, culturally sensitive approach. The article advocates for a globally coordinated digital response that not only addresses current disparities in skin health care but also promotes equitable access to digital health resources, making dermatologic care more representative of all skin types and accessible worldwide.
Published: 2024
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2. New experimental findings on the separation of cobalt and nickel from an ammonia-ammonium-based leach liquor using ammonium-saponified Cyanex 272

Author: Godwell Pahla, Freeman Ntuli, and Nomampondo Magwa
Subjects: Ammonium-saponified Cyanex 272, Ammonia leach liquor, Base metal refinery, Cobalt, Nickel, Chemical engineering, TP155-156
Abstract: There is a need to improve cobalt and nickel recovery from industrial waste streams such as secondary leach solutions and rechargeable battery leach solutions due to the increasing economic value of these critical metals. Ammonia is an important lixiviant due to its limited environmental impact compared to acid based lixiviants, however, the subsequent selective extraction of cobalt and nickel from the leach liquor is a major challenge. This study presents new experimental findings on the treatment of a Base metal Refinery (BMR) secondary leach liquor that contains high concentrations of ammonia and ammonium sulphate, and low concentrations of cobalt (∼442 mg/L) and nickel (∼1624 mg/L) using partially saponified Cyanex 272. New knowledge that can be applied in the treatment of ammonia based leachates from various industrial wastes that contain residual cobalt and nickel is presented herein. The investigation was conducted through the determination of the optimum extraction temperature, percentage saponification, and organic to aqueous ratios. Partial saponification of Cyanex 272 increased ammonia-metal complex stability at the interphase and this limited cobalt extraction between 30 °C and 50 °C. However, a high cobalt extraction percentage, and a high separation factor of 94.07 %, and 1189.76 respectively were achieved at 60 °C, 20 % saponification, and 0.5 O/A loadings in a single contact. A second-stage batch extraction produced a nickel aqueous stream with no cobalt. Stripping of the loaded organic phase with dilute sulphuric acid produced a pure cobalt aqueous stream. Further, the extractant was successfully regenerated post stripping. Overall, partial ammonium-saponification increased the extent of cobalt extraction, and selectivity. The novel process conditions reported herein can be used to design sustainable cobalt-nickel separation processes.
Published: 2024
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3. Primary cutaneous malakoplakia of the medial thigh in an 81-year-old immunocompetent patient

Author: Timothy Freeman, BS, Dipti Anand, MD, and Charay Jennings-Dover, MD
Subjects: immunocompetence, malacoplakia, malakoplakia, Dermatology, RL1-803
Published: 2024
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4. Lifestyle Medicine in Medical Education: Maximizing Impact

Author: Beth Frates, MD, FACLM, Hugo A. Ortega, MD, MSEd, DipABLM, Kelly J. Freeman, MSN, AGPCNP-BC, DipACLM, John Patrick T. Co, MD, MPH, MBA, and Melissa Bernstein, PhD, RDN, LD, FAND, DipACLM
Subjects: Medicine (General), R5-920
Abstract: The relationship between lifestyle behaviors and common chronic conditions is well established. Lifestyle medicine (LM) interventions to modify health behaviors can dramatically improve the health of individuals and populations. There is an urgent need to meaningfully integrate LM into medical curricula horizontally across the medical domains and vertically in each year of school and training. Including LM content in medical and health professional curricula and training programs has been challenging. Barriers to LM integration include lack of awareness and prioritization of LM, limited time in the curricula, and too few LM-trained faculty to teach and role model the practice of LM. This limits the ability of health care professionals to provide effective LM and precludes the wide-reaching benefits of LM from being fully realized. Early innovators developed novel tools and resources aligned with current evidence for introducing LM into didactic and experiential learning. This review aimed to examine the educational efforts in each LM pillar for undergraduate and graduate medical education. A PubMed-based literature review was undertaken using the following search terms: lifestyle medicine, education, medical school, residency, and healthcare professionals. We map the LM competencies to the core competency domains of the Accreditation Council for Graduate Medical Education. We highlight opportunities to train faculty, residents, and students. Moreover, we identify available evidence-based resources. This article serves as a “call to action” to incorporate LM across the spectrum of medical education curricula and training.
Published: 2024
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5. National trends, safety, and effectiveness of minimally invasive concomitant chest wall resection for locally advanced lung cancerCentral MessagePerspective

Author: Shawn Purnell, MD, Ayham Odeh, MD, Richard Freeman, MD, MBA, Wissam Raad, MD, FACS, Elliot Servais, MD, FACS, and Zaid Abdelsattar, MD, MS, FACS
Subjects: lung cancer, chest wall invasion, minimally invasive, concomitant resection, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract: Objective: Concomitant chest wall resection for locally advanced lung cancer is traditionally performed via an open approach. The safety and effectiveness of minimally invasive approaches for chest wall resections are unknown. Methods: We used the National Cancer Database to identify patients undergoing lobectomy/bi-lobectomy with concomitant chest wall resection from 2010 to 2020. We stratified patients into those undergoing a minimally invasive resection (video-assisted thoracoscopic surgery [VATS]/robotic) or open, while accounting for conversions. We also compared VATS with robotic approaches. The main outcomes were length of stay, mortality, readmissions, and overall survival. We used multivariable, Kaplan-Meier and Cox proportional models to identify associations. Results: Of 2837 patients, 756 procedures (26.6%) were started minimally invasive, of which 23.1% were robotic. There were 237 (31.3%) conversions. Patients undergoing a minimally invasive operation were similar in terms of age (65.2 ± 9.8 years vs 66.0 ± 9.9 years), sex, race, tumor histology, and location (all P > .05) but had smaller cancers (5.4 ± 2.6 cm vs 6.2 ± 4.3 cm; P
Published: 2024
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6. En bloc chest wall resection in locally advanced cT3N2 (stage IIIB) lung cancer involving the chest wall: Revisiting guidelinesCentral MessagePerspective

Author: Joseph F. Zywiciel, BS, Raymond A. Verm, MD, Wissam Raad, MD, Marshall Baker, MD, FACS, Richard Freeman, MD, MBA, and Zaid M. Abdelsattar, MD, MS, FACS
Subjects: chemoradiation, chest wall resection, cT3N2 lung cancer, NCCN guidelines, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract: Objectives: Current National Comprehensive Cancer Network guidelines recommend definitive chemoradiation rather than surgery for patients with locally advanced clinical stage T3 and N2 (stage IIIB) lung cancer involving the chest wall. The data supporting this recommendation are controversial. We studied whether surgery confers a survival advantage over definitive chemoradiation in the National Cancer Database. Methods: We identified all patients with clinical stage T3 and N2 lung cancer in the National Cancer Database from 2004 to 2017 who underwent a lobectomy with en bloc chest wall resection and compared them with patients with clinical stage T3 and N2 lung cancer who had definitive chemoradiation. We used propensity score matching to minimize confounding by indication while excluding patients with tumors in the upper lobes to exclude Pancoast tumors. We used 1:1 propensity score matching and Kaplan–Meir survival analyses to estimate associations. Results: Of 4467 patients meeting all inclusion/exclusion criteria, 210 (4.49%) had an en bloc chest wall resection. Patients undergoing surgical resection were younger (mean age = 60.3 ± 10.3 years vs 67.5 ± 10.4 years; P
Published: 2024
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7. Promise of Lifestyle Medicine for Heart Disease, Diabetes Mellitus, and Cerebrovascular Diseases

Author: Aleksandra Pikula, MD, Mahima Gulati, MD, MSc, Jonathan P. Bonnet, MD, MPH, Sarah Ibrahim, MN, PhD, Svetlana Chamoun, MD, PhD, Andrew M. Freeman, MD, and Koushik Reddy, MD
Subjects: Medicine (General), R5-920
Abstract: The burden of noncommunicable chronic diseases has relevant and negative consequences to persons, health care systems, and economies worldwide. Chronic diseases are the leading cause of disability and mortality and are responsible for 90% of health care expenditure. The most common chronic diseases are diabetes mellitus (DM), cardiovascular disease, and cerebrovascular disease (stroke and vascular cognitive impairment). Modifiable risk factors (MRFs) for these conditions include hypertension, hyperlipidemia, smoking, poor diet, and low-physical activity; with hypertension being the most prevalent MRF. Most MRFs can be successfully targeted through lifestyle medicine (LSM), which is a medical specialty that addresses the root causes of chronic diseases through its primary, secondary, and tertiary preventative approaches. Lifestyle medicine comprises 6 pillars (nutrition, physical activity, sleep health, stress reduction, social connections, and substance use) which through various behavioral approaches, focus on regular physical activity, healthy eating, good quality and quantity sleep, and meaningful social connections coupled with the reduction of stress and substance use. This paper will briefly review the evidence and promise of individual LSM pillars in addressing the underlying MRFs of DM, cardiovascular and cerebrovascular disease (specifically stroke and vascular cognitive impairment). Lifestyle medicine holds a great promise for comprehensive and much improved population health. However, the adoption of LSM at the societal scale requires a multifaceted approach and widespread integration would galvanize a paradigm shift to prevent, treat or reverse chronic diseases from the root causes and achieve health equity.
Published: 2024
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8. Fraud and corporate psychopaths: The proposition for reintroducing personality traits of the economic crime offender

Author: Clive R. Boddy, Christopher Freeman, and Elina Karpacheva-Hock
Subjects: Fraud, Corporate psychopaths, Antecedents of fraud, Toxic leadership, Psychopathy, Predatory fraud, Social pathology. Social and public welfare. Criminology, HV1-9960
Abstract: There is strong evidence that corporate psychopaths – ruthless people who willingly engage in fraud and even enjoy outwitting and stealing from others – are a dominant force at senior levels in financial organizations. While corporate psychopathy has obvious implications for fraud and causes significant societal harm (both financial and non-financial), its correlation with fraud has had minimal coverage in both the academic accountancy literature and counter-fraud literature. This paper fills this gap by discussing the presence of corporate psychopaths in organizations as a theoretical antecedent to fraud. The paper outlines what are the most common personality traits of corporate psychopaths and how they might be correlated with fraud. By introducing the concept of corporate psychopath into the counter-fraud discourse, this paper aims to enrich criminological perspectives on personality of economic crime offenders for effective prevention and policing. The paper notes the systemic influence that leaders with personality disorders, like psychopathy, may have on the ethical climate of an organization and concludes that further empirical research on the links between corporate psychopaths and fraud is needed. Eight specific research propositions are suggested.
Published: 2024
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9. terraFlow, a high-parameter analysis tool, reveals T cell exhaustion and dysfunctional cytokine production in classical Hodgkin’s lymphoma

Author: Daniel Freeman, Catherine Diefenbach, Linda Lam, Tri Le, Jason Alexandre, Bruce Raphael, Michael Grossbard, David Kaminetzky, Jia Ruan, and Pratip K. Chattopadhyay
Subjects: CP: Cancer, CP: Immunology, Biology (General), QH301-705.5
Abstract: Summary: Immune cells express an incredible variety of proteins; by measuring combinations of these, cell types influencing disease can be precisely identified. We developed terraFlow, a platform that defines cell subsets exhaustively by combinatorial protein expression. Using high-parameter checkpoint-focused and function-focused panels, we studied classical Hodgkin’s lymphoma (cHL), where systemic T cells have not been investigated in detail. terraFlow revealed immune perturbations in patients, including elevated activated, exhausted, and interleukin (IL)-17+ phenotypes, along with diminished early, interferon (IFN)γ+, and tumor necrosis factor (TNF)+ T cells before treatment; many perturbations remained after treatment. terraFlow identified more disease-associated differences than other tools, often with better predictive power, and included a non-gating approach, eliminating time-consuming and subjective manual thresholds. It also reports a method to identify the smallest set of markers distinguishing study groups. Our results provide mechanistic support for past reports of immune deficiency in cHL and demonstrate the value of terraFlow in immunotherapy and biomarker studies.
Published: 2024
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10. Altered epidemiological patterns of Respiratory Syncytial Virus and influenza detections in a tropical Australian setting 2020 to 2023

Author: Joanne C. Nixon, Kevin Freeman, and Rob W. Baird
Subjects: Respiratory Syncytial virus, influenza, altered disease epidemiology, Public aspects of medicine, RA1-1270
Abstract: Background: We describe the recent temporal patterns of respiratory syncytial virus (RSV) and influenza virus detections in the Northern Territory (NT) of Australia, between 2020 and 2023. Methods: This retrospective analysis of patients presenting with respiratory diseases utilised a multiplex viral nucleic acid detection assay for RSV, influenza and SARS Cov2 (COVID-19) to determine the relative frequency of non-COVID-19 respiratory viral detections by age and month during the study period. Results: During this period of the NT COVID-19 epidemic, disruption of the usual annual wet season RSV outbreak patterns occurred, and the yearly influenza peak was absent for two annual cycles. Our data also reveals that 25% of RSV infections were occurring in patients greater than 40 years of age, compared to 32% of influenza infections presenting in the same period, documenting a greater burden of adult disease than previously documented in the NT. Conclusions: Loss of non-COVID-19 viral seasonality and a substantial unrecognised RSV adult burden were noted. We will continue to monitor seasonality, and the RSV burden and this will help to target the populations benefiting from recently released RSV vaccine.
Published: 2024
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11. Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons

Author: Shichen Wu, Junkai Xie, Han Zhao, Xihui Zhao, Oscar F. Sánchez, Jean-Christophe Rochet, Jennifer L. Freeman, and Chongli Yuan
Subjects: PFOA exposure, PFAS, hiPSC-derived cortical neurons, Alzheimer’s Disease, Neurotoxicity, Environmental sciences, GE1-350
Abstract: PFOA is a legacy Per- and Polyfluorinated Substances (PFAS), a group of chemicals widely used in various industrial applications and consumer products. Although there has been a voluntary phase out of PFOA since 2005, it is still widely detected in various water supplies. A growing body of evidence suggests an association between PFOA exposure, particularly during developmental stages, with increased risks of neurodegenerative diseases (NDs). The neurotoxic mechanism of developmental PFOA exposure, however, remains poorly understood. Utilizing human induced-pluripotent stem cell (hiPSC)-derived cortical neurons, we investigated the effect of PFOA exposure prior to differentiation and assessed changes in neuronal characteristics, transcriptome, and neurodegeneration markers mimicking a Developmental Origin of Health and Disease (DoHAD) paradigm. Exposure to PFOA before neuron differentiation resulted in persistent alterations in nuclear morphology, neuronal network, and calcium activity. RNA sequencing analysis further revealed transcriptomic changes aligning with Alzheimer’s Disease (AD) after PFOA exposure. These observations were further corroborated by alterations in tau phosphorylation markers, the presence of fibrillar tau, an increase in liquid droplets, and a decrease in RNA translational efficiency characterized using a battery of biochemical assays. Taken together, our results revealed persistent deficits of key neuronal characteristics induced by pre-differentiation PFOA exposure, suggesting impairments in several AD-related pathways that can together contribute to the elevation of AD risk after pre-differentiation PFOA exposure.
Published: 2024
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12. Evidence for tWZ production in proton-proton collisions at s=13 TeV in multilepton final states

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, M.A. Shahzad, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, S. Elgammal, A. Ellithi Kamel, A. Lotfy, M.A. Mahmoud, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, I. Lomidze, T. Toriashvili, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, S.C. Schuler, A. Sharma, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, M. Shchedrolosiev, R.E. Sosa Ricardo, L.P. Sreelatha Pramod, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H.J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R.F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M.M.A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, G.I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, T. Csorgo, F. 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Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, M.R. Adams, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, T.Á. Vámi, A. Abreu, L.F. 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Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, C. Fangmeier, F. Golf, G. Haza, J. Hossain, C. Joo, I. Kravchenko, I. Reed, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, A.G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. 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Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Single top quark, Z boson, Machine learning, Multilepton, Physics, QC1-999
Abstract: The first evidence for the standard model production of a top quark in association with a W boson and a Z boson is reported. The measurement is performed in multilepton final states, where the Z boson is reconstructed via its decays to electron or muon pairs. At least one W boson, associated or from top quark decay, decays leptonically, too. The analysed data were recorded by the CMS experiment at the CERN LHC in 2016–2018 in proton-proton collisions at s=13 TeV, and correspond to an integrated luminosity of 138 fb−1. The measured cross section is 354±54(stat)±95(syst) fb, and corresponds to a statistical significance of 3.4 standard deviations.
Published: 2024
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13. KS0 and Λ(Λ‾) two-particle femtoscopic correlations in PbPb collisions at sNN=5.02TeV

Author: A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E.S. Bols, J. D'Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, A. Morton, D. Müller, A.R. Sahasransu, S. Tavernier, W. Van Doninck, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, A. Taliercio, T.T. Tran, P. Vischia, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, A.A. Abdelalim, E. Salama, M.A. Mahmoud, Y. Mohammed, S. Bhowmik, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, K. 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Askew, N. Bower, R. Habibullah, V. Hagopian, T. Kolberg, G. Martinez, H. Prosper, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, F. Yumiceva, M.R. Adams, R. Cavanaugh, S. Dittmer, O. Evdokimov, C.E. Gerber, D.J. Hofman, D.S. Lemos, A.H. Merrit, C. Mills, G. Oh, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, O. Amram, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, S. Kyriacou, P. Maksimovic, J. Roskes, S. Sekhar, M. Swartz, T.Á. Vámi, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, S. Duric, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, T. Mitchell, A. Modak, K. Nam, D. Roy, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, L. Wang, K. Wong, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, M. Hu, D. Kovalskyi, J. Krupa, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, Z. Shi, G.S.F. Stephans, Z. Wang, B. Wyslouch, T.J. Yang, R.M. Chatterjee, B. Crossman, J. Hiltbrand, B.M. Joshi, C. Kapsiak, M. Krohn, Y. Kubota, D. Mahon, J. Mans, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, C. Fangmeier, L. Finco, F. Golf, C. Joo, R. Kamalieddin, I. Kravchenko, I. Reed, J.E. Siado, G.R. Snow, W. Tabb, A. Wightman, F. Yan, A.G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, J. Lidrych, G. Madigan, B. Marzocchi, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K.A. Hahn, Y. Liu, N. Odell, M.H. Schmitt, M. Velasco, R. Band, R. Bucci, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J.F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, H. Wang, H. Acharya, A.G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, M. Chadeeva, V. Chekhovsky, M. Danilov, A. Dermenev, T. Dimova, I. Dremin, V. Epshteyn, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, A. Kaminskiy, L. Kardapoltsev, V. Karjavine, A. Karneyeu, L. Khein, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, O. Kodolova, D. Konstantinov, V. Korenkov, V. Korotkikh, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, A. Litomin, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, I. Ovtin, V. Palichik, V. Perelygin, S. Petrushanko, V. Popov, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, I. Vardanyan, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Heavy ion, V0, Femtoscopy, Scattering parameters, Physics, QC1-999
Abstract: Two-particle correlations are presented for KS0, Image 1, and Image 2 strange hadrons as a function of relative momentum in lead-lead collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV. The dataset corresponds to an integrated luminosity of 0.607nb−1 and was collected using the CMS detector at the CERN LHC. These correlations are sensitive to quantum statistics and to final-state interactions between the particles. The source size extracted from the KS0KS0 correlations is found to decrease from 4.6 to 1.6fm in going from central to peripheral collisions. Strong interaction scattering parameters (i.e., scattering length and effective range) are determined from the Image 3 and Image 4 (including their charge conjugates) correlations using the Lednický–Lyuboshitz model and are compared to theoretical and other experimental results.
Published: 2024
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14. Searches for violation of Lorentz invariance in top quark pair production using dilepton events in 13 TeV proton-proton collisions

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Clerbaux, A.K. Das, G. De Lentdecker, L. Favart, P. Gianneios, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, K. Mota Amarilo, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, L. Mundim, H. Nogima, J.P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, A. Lotfy, M.A. Mahmoud, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, K.T.S. Kallonen, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. Meena, G. Saha, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, I. Lomidze, T. Toriashvili, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, J. Erdmann, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, U. Sarkar, V. Sarkisovi, A. Schmidt, A. Sharma, J.L. Spah, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. 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Vámi, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J. Mao, H.B. Newman, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, M.B. Andrews, P. Bryant, M. Cremonesi, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, P. Palit, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, P. Kotamnives, J. Monroy, M. Oshiro, J.R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, S. Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Top quark, Beyond standard model, Lorentz symmetry, Physics, QC1-999
Abstract: A search for violation of Lorentz invariance in the production of top quark pairs (tt‾) is presented. The measured normalized differential tt‾ production cross section, as a function of the sidereal time, is examined for potential modulations induced by Lorentz-invariance breaking operators in an effective field theory extension of the standard model (SM). The cross section is measured from collision events collected by the CMS detector at a center-of-mass-energy of 13 TeV, corresponding to an integrated luminosity of 77.8 fb−1, and containing one electron and one muon. The results are found to be compatible with zero, in agreement with the SM, and are used to place upper limits at 68% confidence level on the magnitude of the Lorentz-violating couplings ranging from 1–8×10−3. This is the first precision test of the isotropy in special relativity with top quarks at the LHC, restricting further the bounds on such couplings by up to two orders of magnitude with respect to previous searches conducted at the Tevatron.
Published: 2024
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15. UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

Author: F. Abate, A. Adu-Amankwah, KA Ae-Ngibise, F Agbokey, VA Agyemang, CT Agyemang, C. Akgun, J. Ametepe, T. Arichi, KP Asante, S. Balaji, L. Baljer, PJ Basser, J. Beauchemin, C. Bennallick, Y. Berhane, Y. Boateng-Mensah, NJ Bourke, L. Bradford, MMK Bruchhage, R.Cano Lorente, P. Cawley, M. Cercignani, V. D Sa, A.de Canha, N.de Navarro, DC Dean, III, J. Delarosa, KA Donald, A. Dvorak, AD Edwards, D. Field, H. Frail, B. Freeman, T. George, J. Gholam, J. Guerrero-Gonzalez, JV Hajnal, R. Haque, W. Hollander, Z. Hoodbhoy, M. Huentelman, SK Jafri, DK Jones, F. Joubert, T. Karaulanov, MP Kasaro, S. Knackstedt, S. Kolind, B. Koshy, R. Kravitz, S.Lecurieux Lafayette, AC Lee, B. Lena, N. Lepore, M. Linguraru, E. Ljungberg, Z. Lockart, E. Loth, P. Mannam, KM Masemola, R. Moran, D. Murphy, FL Nakwa, V. Nankabirwa, CA Nelson, K. North, S. Nyame, R. O Halloran, J. O'Muircheartaigh, BF Oakley, H. Odendaal, CM Ongeti, D. Onyango, SA Oppong, F. Padormo, D. Parvez, T. Paus, MS Pepper, KS Phiri, M. Poorman, JE Ringshaw, J. Rogers, M. Rutherford, H. Sabir, L. Sacolick, M. Seal, ML Sekoli, T. Shama, K. Siddiqui, N. Sindano, MB Spelke, PE Springer, FE Suleman, PC Sundgren, R. Teixeira, W. Terekegn, M. Traughber, MG Tuuli, J.van Rensburg, F. Váša, S. Velaphi, P. Velasco, IM Viljoen, M. Vokhiwa, A. Webb, C. Weiant, N. Wiley, P. Wintermark, K. Yibetal, SCL Deoni, and SCR Williams
Subjects: Neurodevelopment, Child Health, Global Health, Healthy Development, Environmental Adversity, Low Field Magnetic Resonance Imaging, Neurophysiology and neuropsychology, QP351-495
Abstract: Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12–18 months of a child’s life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia.
Published: 2024
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16. The benefits of long-duration energy storage for New England’s energy system decarbonization goals

Author: Sergio Freeman and Ertan Agar
Subjects: Energy reliability, Long-duration energy storage (LDES), New England, Power-to-gas-to-power (P2G2P), Redox flow battery (RFB), Renewable energy, Energy industries. Energy policy. Fuel trade, HD9502-9502.5, Renewable energy sources, TJ807-830
Abstract: Utilizing a macro-scale energy model alongside 44 years of New England’s hourly weather data from MERRA-2, this study investigates the benefits of various combinations of renewable energy technologies, particularly wind and solar, and their integration with long-duration energy storage (LDES) systems. The potential of these renewable energy sources to enhance both the reliability and affordability of New England’s power system is evaluated. The findings demonstrate that incorporating LDES into the technology mix leads to a remarkable 55% reduction in overall system costs compared to relying solely on short-duration energy storage (SDES), such as lithium-ion batteries. Additionally, the cost reductions of LDES lead to approximately a 35% increase in the utilization of solar generation. The results suggest that total system costs for LDES are more responsive to relative decreases in power-capacity costs than decreases in energy-capacity costs. Furthermore, the analysis indicates that a combination of different LDES storage technologies can offer the most cost-effective solution for wind-solar power systems. Overall, by examining the interplay between different storage technologies and their impact on system costs, this research contributes significantly to the discourse on sustainable energy solutions.
Published: 2024
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17. Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma

Author: Talal El Zarif, Karl Semaan, Marc Eid, Ji-Heui Seo, Simon Garinet, Matthew P. Davidsohn, Pranshu Sahgal, Brad Fortunato, John Canniff, Amin H. Nassar, Sarah Abou Alaiwi, Ziad Bakouny, Gitanjali Lakshminarayanan, Hunter Savignano, Kevin Lyons, Sayed Matar, Atef Ali, Eddy Saad, Renee Maria Saliby, Paulo Cordeiro, Ziwei Zhang, Nourhan El Ahmar, Yasmin Nabil Laimon, Chris Labaki, Valisha Shah, Dory Freeman, Jillian O’Toole, Gwo-Shu Mary Lee, Justin Hwang, Mark Pomerantz, Sabina Signoretti, Eliezer M. Van Allen, Wanling Xie, Jacob E. Berchuck, Srinivas R. Viswanathan, David A. Braun, Toni K. Choueiri, Matthew L. Freedman, and Sylvan C. Baca
Subjects: CP: Cancer, CP: Genomics, Biology (General), QH301-705.5
Abstract: Summary: Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to improving outcomes for sRCC are the limited understanding of its gene regulatory programs and the low diagnostic yield of tumor biopsies due to spatial heterogeneity. Herein, we characterized the epigenomic landscape of sRCC by profiling 107 epigenomic libraries from tissue and plasma samples from 50 patients with RCC and healthy volunteers. By profiling histone modifications and DNA methylation, we identified highly recurrent epigenomic reprogramming enriched in sRCC. Furthermore, CRISPRa experiments implicated the transcription factor FOSL1 in activating sRCC-associated gene regulatory programs, and FOSL1 expression was associated with the response to ICIs in RCC in two randomized clinical trials. Finally, we established a blood-based diagnostic approach using detectable sRCC epigenomic signatures in patient plasma, providing a framework for discovering epigenomic correlates of tumor histology via liquid biopsy.
Published: 2024
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18. Impact of the COVID-19 pandemic on intracranial aneurysm treatment and associated Outcomes: A nationwide US-based study

Author: Abdul Karim Ghaith, Victor Gabriel El-Hajj, Jorge Rios-Zermeno, Elena Greco, David A. Miller, Erik H. Middlebrooks, William D. Freeman, Adrian Elmi-Terander, Sukhwinder S. Sandhu, and Rabih G. Tawk
Subjects: Intracranial aneurysms, Endovascular, Clip, Coronavirus, Covid-19, Stroke, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429
Abstract: Objective: Limited data on the treatment and outcomes of patients with intracranial aneurysms (ICAs) in the (coronavirus disease 2019) COVID-19 era is available. Our objective was hence to investigate the impact of the pandemic on the overall complication rate and postprocedural ischemic strokes specifically, in patients treated for ICAs. Methods: The National Inpatient sample database was used. The main outcomes were the occurrence of postprocedural ischemic strokes, as well as death, non-routine discharge, total charges (US dollars), and length of stay (days). Propensity score matching was applied to compare the pre- and COVID-19 periods. Trends were assessed using piecewise joinpoint regression with the Mann-Kendall test. Results: A total of 57,715 patients were included in the study. The mean age was 65 years, with most of the patients (69.9 %) being females. After matching, no differences in length of stay (p = 0.266), non-home discharge (p = 0.475), and in-hospital mortality rates (p = 0.305) between the two periods were found. However, the overall complication rate was significantly higher during the pandemic (31.1 % vs. 28.3 %; p
Published: 2024
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19. Urinary biomonitoring of glyphosate exposure among male farmers and nonfarmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study

Author: Vicky C. Chang, Maria Ospina, Shuai Xie, Gabriella Andreotti, Christine G. Parks, Danping Liu, Jessica M. Madrigal, Mary H. Ward, Nathaniel Rothman, Debra T. Silverman, Dale P. Sandler, Melissa C. Friesen, Laura E. Beane Freeman, Antonia M. Calafat, and Jonathan N. Hofmann
Subjects: Glyphosate, Farmers, Occupational exposure, Human biomonitoring, Urine, Environmental sciences, GE1-350
Abstract: Glyphosate is the most widely applied herbicide worldwide. Glyphosate biomonitoring data are limited for agricultural settings. We measured urinary glyphosate concentrations and assessed exposure determinants in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study. We selected four groups of BEEA participants based on self-reported pesticide exposure: recently exposed farmers with occupational glyphosate use in the last 7 days (n = 98), farmers with high lifetime glyphosate use (>80th percentile) but no use in the last 7 days (n = 70), farming controls with minimal lifetime use (n = 100), and nonfarming controls with no occupational pesticide exposures and no recent home/garden glyphosate use (n = 100). Glyphosate was quantified in first morning void urine using ion chromatography isotope-dilution tandem mass spectrometry. We estimated associations between urinary glyphosate concentrations and potential determinants using multivariable linear regression. Glyphosate was detected (≥0.2 µg/L) in urine of most farmers with recent (91 %) and high lifetime (93 %) use, as well as farming (88 %) and nonfarming (81 %) controls; geometric mean concentrations were 0.89, 0.59, 0.46, and 0.39 µg/L (0.79, 0.51, 0.42, and 0.37 µg/g creatinine), respectively. Compared with both control groups, urinary glyphosate concentrations were significantly elevated among recently exposed farmers (P
Published: 2024
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20. Search for an exotic decay of the Higgs boson into a Z boson and a pseudoscalar particle in proton-proton collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, C. Zhou, Z. You, N. Lu, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M. Abdullah Al-Mashad, M.A. Mahmoud, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, M. Vander Donckt, P. Verdier, J. Xiao, A. Khvedelidze, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, S.C. Schuler, A. Sharma, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, V. Scheurer, S. Schnake, P. Schütze, C. Schwanenberger, M. Shchedrolosiev, R.E. Sosa Ricardo, L.P. Sreelatha Pramod, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, I. Shvetsov, H.J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R.F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, D. Karasavvas, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M.M.A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, G.I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S.B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, R. Gupta, A. Kaur, H. Kaur, M. Kaur, S. Kumar, P. Kumari, M. Meena, K. Sandeep, T. Sheokand, J.B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B.C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Baradia, S. Barman, D. Bhowmik, S. Dutta, B. Gomber, P. Palit, G. Saha, B. Sahu, S. Sarkar, M.M. Ameen, P.K. Behera, S.C. Behera, P. Jana, P. Kalbhor, J.R. Komaragiri, D. Kumar, L. Panwar, R. Pradhan, P.R. Pujahari, N.R. Saha, A.K. Sikdar, S. Verma, T. Aziz, I. Das, S. Dugad, M. Kumar, G.B. Mohanty, P. Suryadevara, A. Bala, S. Banerjee, R.M. Chatterjee, M. Guchait, S. Karmakar, G. Majumder, K. Mazumdar, A. Thachayath, S. Bahinipati, A.K. Das, C. Kar, D. Maity, P. Mal, T. Mishra, V.K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, P. Sadangi, P. Saha, S.K. Swain, S. Varghese, D. Vats, A. Alpana, S. Dube, B. Kansal, A. Laha, A. Rastogi, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S.M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, A. Colaleo, D. Creanza, B. D'Anzi, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, G. Ramirez-Sanchez, D. Ramos, A. Ranieri, L. Silvestris, F.M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, R. Campanini, P. Capiluppi, A. Castro, F.R. Cavallo, M. Cuffiani, G.M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, C. Grandi, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F.L. Navarria, A. Perrotta, F. Primavera, A.M. Rossi, T. Rovelli, G.P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D'Alessandro, E. Focardi, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, A. Papanastassiou, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, G. Boldrini, F. Brivio, F. Cetorelli, F. De Guio, M.E. Dinardo, P. Dini, S. Gennai, A. Ghezzi, P. Govoni, L. Guzzi, M.T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, B.S. Pinolini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, D. Zuolo, S. Buontempo, A. Cagnotta, F. Carnevali, N. Cavallo, A. De Iorio, F. Fabozzi, A.O.M. Iorio, L. Lista, P. Paolucci, B. Rossi, C. Sciacca, R. Ardino, P. Azzi, N. Bacchetta, A. Bergnoli, D. Bisello, P. Bortignon, A. Bragagnolo, R. Carlin, P. Checchia, T. Dorigo, F. Gasparini, U. Gasparini, G. Grosso, L. Layer, E. Lusiani, M. Margoni, A.T. Meneguzzo, M. Migliorini, J. Pazzini, P. Ronchese, R. Rossin, F. Simonetto, G. Strong, M. Tosi, A. Triossi, S. Ventura, H. Yarar, P. Zotto, A. Zucchetta, G. Zumerle, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, S. Ajmal, P. Asenov, G.M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Piccinelli, M. Presilla, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Azzurri, G. Bagliesi, R. Bhattacharya, L. Bianchini, T. Boccali, E. Bossini, D. Bruschini, R. Castaldi, M.A. Ciocci, M. Cipriani, V. D'Amante, R. Dell'Orso, S. Donato, A. Giassi, F. Ligabue, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, S. Parolia, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, A. Scribano, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, A. Venturi, P.G. Verdini, P. Barria, M. Campana, F. Cavallari, L. Cunqueiro Mendez, D. Del Re, E. Di Marco, M. Diemoz, F. Errico, E. Longo, P. Meridiani, J. Mijuskovic, G. Organtini, F. Pandolfi, R. Paramatti, C. Quaranta, S. Rahatlou, C. Rovelli, F. Santanastasio, L. Soffi, R. Tramontano, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, N. Bartosik, R. Bellan, A. Bellora, C. Biino, N. Cartiglia, M. Costa, R. Covarelli, N. Demaria, L. Finco, M. Grippo, B. Kiani, F. Legger, F. Luongo, C. Mariotti, S. Maselli, A. Mecca, E. Migliore, M. Monteno, R. Mulargia, M.M. Obertino, G. Ortona, L. Pacher, N. Pastrone, M. Pelliccioni, M. Ruspa, F. Siviero, V. Sola, A. Solano, D. Soldi, A. Staiano, C. Tarricone, M. Tornago, D. Trocino, G. Umoret, E. Vlasov, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, K. De Leo, G. Della Ricca, S. Dogra, J. Hong, C. Huh, B. Kim, D.H. Kim, J. Kim, H. Lee, S.W. Lee, C.S. Moon, Y.D. Oh, S.I. Pak, M.S. Ryu, S. Sekmen, Y.C. Yang, G. Bak, P. Gwak, H. Kim, D.H. Moon, E. Asilar, D. Kim, T.J. Kim, J.A. Merlin, J. Park, S. Choi, S. Han, B. Hong, K.S. Lee, S. Lee, S.K. Park, J. Yoo, J. Goh, H.S. Kim, Y. Kim, J. Almond, J.H. Bhyun, S. Jeon, W. Jun, J.S. Kim, S. Ko, H. Kwon, J. Lee, B.H. Oh, S.B. Oh, H. Seo, U.K. Yang, I. Yoon, W. Jang, D.Y. Kang, Y. Kang, S. Kim, B. Ko, J.S.H. Lee, Y. Lee, I.C. Park, Y. Roh, I.J. Watson, S. Yang, S. Ha, H.D. Yoo, M. Choi, M.R. Kim, I. Yu, T. Beyrouthy, Y. Maghrbi, K. Dreimanis, A. Gaile, G. Pikurs, A. Potrebko, M. Seidel, V. Veckalns, N.R. Strautnieks, M. Ambrozas, A. Juodagalvis, A. Rinkevicius, G. Tamulaitis, N. Bin Norjoharuddeen, I. Yusuff, Z. Zolkapli, J.F. Benitez, A. Castaneda Hernandez, H.A. Encinas Acosta, L.G. Gallegos Maríñez, M. León Coello, J.A. Murillo Quijada, A. Sehrawat, L. Valencia Palomo, G. Ayala, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-De La Cruz, R. Lopez-Fernandez, C.A. Mondragon Herrera, A. Sánchez Hernández, C. Oropeza Barrera, M. Ramírez García, I. Bautista, I. Pedraza, H.A. Salazar Ibarguen, C. Uribe Estrada, I. Bubanja, N. Raicevic, P.H. Butler, A. Ahmad, M.I. Asghar, A. Awais, M.I.M. Awan, H.R. Hoorani, W.A. Khan, V. Avati, L. Grzanka, M. Malawski, H. Bialkowska, M. Bluj, B. Boimska, M. Górski, M. Kazana, M. Szleper, P. Zalewski, K. Bunkowski, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, A. Muhammad, K. Pozniak, W. Zabolotny, M. Araujo, D. Bastos, C. Beirão Da Cruz E Silva, A. Boletti, M. Bozzo, P. Faccioli, M. Gallinaro, J. Hollar, N. Leonardo, T. Niknejad, A. Petrilli, M. Pisano, J. Seixas, J. Varela, P. Adzic, P. Milenovic, M. Dordevic, J. Milosevic, V. Rekovic, M. Aguilar-Benitez, J. Alcaraz Maestre, M. Barrio Luna, Cristina F. Bedoya, M. Cepeda, M. Cerrada, N. Colino, B. De La Cruz, A. Delgado Peris, D. Fernández Del Val, J.P. Fernández Ramos, J. Flix, M.C. Fouz, O. Gonzalez Lopez, S. Goy Lopez, J.M. Hernandez, M.I. Josa, J. León Holgado, D. Moran, C.M. Morcillo Perez, Á. Navarro Tobar, C. Perez Dengra, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, I. Redondo, D.D. Redondo Ferrero, L. Romero, S. Sánchez Navas, L. Urda Gómez, J. Vazquez Escobar, C. Willmott, J.F. de Trocóniz, B. Alvarez Gonzalez, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, J.R. González Fernández, E. Palencia Cortezon, C. Ramón Álvarez, V. Rodríguez Bouza, A. Soto Rodríguez, A. Trapote, C. Vico Villalba, P. Vischia, S. Bhowmik, S. Blanco Fernández, J.A. Brochero Cifuentes, I.J. Cabrillo, A. Calderon, J. Duarte Campderros, M. Fernandez, C. Fernandez Madrazo, G. Gomez, C. Lasaosa García, C. Martinez Rivero, P. Martinez Ruiz del Arbol, F. Matorras, P. Matorras Cuevas, E. Navarrete Ramos, J. Piedra Gomez, C. Prieels, L. Scodellaro, I. Vila, J.M. Vizan Garcia, M.K. Jayananda, B. Kailasapathy, D.U.J. Sonnadara, D.D.C. Wickramarathna, W.G.D. Dharmaratna, K. Liyanage, N. Perera, N. Wickramage, D. Abbaneo, C. Amendola, E. Auffray, G. Auzinger, J. Baechler, D. Barney, A. Bermúdez Martínez, M. Bianco, B. Bilin, A.A. Bin Anuar, A. Bocci, E. Brondolin, C. Caillol, T. Camporesi, G. Cerminara, N. Chernyavskaya, D. d'Enterria, A. Dabrowski, A. David, A. De Roeck, M.M. Defranchis, M. Deile, M. Dobson, F. Fallavollita, L. Forthomme, G. Franzoni, W. Funk, S. Giani, D. Gigi, K. Gill, F. Glege, L. Gouskos, M. Haranko, J. Hegeman, V. Innocente, T. James, P. Janot, J. Kieseler, S. Laurila, P. Lecoq, E. Leutgeb, C. Lourenço, B. Maier, L. Malgeri, M. Mannelli, A.C. Marini, F. Meijers, S. Mersi, E. Meschi, V. Milosevic, F. Moortgat, M. Mulders, S. Orfanelli, F. Pantaleo, M. Peruzzi, G. Petrucciani, A. Pfeiffer, M. Pierini, D. Piparo, H. Qu, D. Rabady, G. Reales Gutiérrez, M. Rovere, H. Sakulin, S. Scarfi, M. Selvaggi, K. Shchelina, P. Silva, P. Sphicas, A.G. Stahl Leiton, A. Steen, S. Summers, D. Treille, P. Tropea, A. Tsirou, D. Walter, J. Wanczyk, K.A. Wozniak, P. Zehetner, P. Zejdl, W.D. Zeuner, T. Bevilacqua, L. Caminada, A. Ebrahimi, W. Erdmann, R. Horisberger, Q. Ingram, H.C. Kaestli, D. Kotlinski, C. Lange, M. Missiroli, L. Noehte, T. Rohe, T.K. Aarrestad, K. Androsov, M. Backhaus, A. Calandri, C. Cazzaniga, K. Datta, A. De Cosa, G. Dissertori, M. Dittmar, M. Donegà, F. Eble, M. Galli, K. Gedia, F. Glessgen, C. Grab, D. Hits, W. Lustermann, A.-M. Lyon, R.A. Manzoni, M. Marchegiani, L. Marchese, C. Martin Perez, A. Mascellani, F. Nessi-Tedaldi, F. Pauss, V. Perovic, S. Pigazzini, M.G. Ratti, M. Reichmann, C. Reissel, T. Reitenspiess, B. Ristic, F. Riti, D. Ruini, D.A. Sanz Becerra, R. Seidita, J. Steggemann, D. Valsecchi, R. Wallny, C. Amsler, P. Bärtschi, C. Botta, D. Brzhechko, M.F. Canelli, K. Cormier, R. Del Burgo, J.K. Heikkilä, M. Huwiler, W. Jin, A. Jofrehei, B. Kilminster, S. Leontsinis, S.P. Liechti, A. Macchiolo, P. Meiring, V.M. Mikuni, U. Molinatti, I. Neutelings, A. Reimers, P. Robmann, S. Sanchez Cruz, K. Schweiger, M. Senger, Y. Takahashi, C. Adloff, C.M. Kuo, W. Lin, P.K. Rout, P.C. Tiwari, S.S. Yu, L. Ceard, Y. Chao, K.F. Chen, P.s. Chen, Z.g. Chen, W.-S. Hou, T.h. Hsu, Y.w. Kao, R. Khurana, G. Kole, Y.y. Li, R.-S. Lu, E. Paganis, A. Psallidas, X.f. Su, J. Thomas-Wilsker, H.y. Wu, E. Yazgan, C. Asawatangtrakuldee, N. Srimanobhas, V. Wachirapusitanand, D. Agyel, F. Boran, Z.S. Demiroglu, F. Dolek, I. Dumanoglu, E. Eskut, Y. Guler, E. Gurpinar Guler, C. Isik, O. Kara, A. Kayis Topaksu, U. Kiminsu, G. Onengut, K. Ozdemir, A. Polatoz, B. Tali, U.G. Tok, S. Turkcapar, E. Uslan, I.S. Zorbakir, K. Ocalan, M. Yalvac, B. Akgun, I.O. Atakisi, E. Gülmez, M. Kaya, O. Kaya, S. Tekten, A. Cakir, K. Cankocak, Y. Komurcu, S. Sen, O. Aydilek, S. Cerci, V. Epshteyn, B. Hacisahinoglu, I. Hos, B. Isildak, B. Kaynak, S. Ozkorucuklu, O. Potok, H. Sert, C. Simsek, D. Sunar Cerci, C. Zorbilmez, A. Boyaryntsev, B. Grynyov, L. Levchuk, D. Anthony, J.J. Brooke, A. Bundock, F. Bury, E. Clement, D. Cussans, H. Flacher, M. Glowacki, J. Goldstein, H.F. Heath, L. Kreczko, B. Krikler, S. Paramesvaran, S. Seif El Nasr-Storey, V.J. Smith, N. Stylianou, K. Walkingshaw Pass, R. White, A.H. Ball, K.W. Bell, A. Belyaev, C. Brew, R.M. Brown, D.J.A. Cockerill, C. Cooke, K.V. Ellis, K. Harder, S. Harper, M.-L. Holmberg, Sh. Jain, J. Linacre, K. Manolopoulos, D.M. Newbold, E. Olaiya, D. Petyt, T. Reis, G. Salvi, T. Schuh, C.H. Shepherd-Themistocleous, I.R. Tomalin, T. Williams, R. Bainbridge, P. Bloch, C.E. Brown, O. Buchmuller, V. Cacchio, C.A. Carrillo Montoya, G.S. Chahal, D. Colling, J.S. Dancu, P. Dauncey, G. Davies, J. Davies, M. Della Negra, S. Fayer, G. Fedi, G. Hall, M.H. Hassanshahi, A. Howard, G. Iles, M. Knight, J. Langford, L. Lyons, A.-M. Magnan, S. Malik, A. Martelli, M. Mieskolainen, J. Nash, M. Pesaresi, B.C. Radburn-Smith, A. Richards, A. Rose, C. Seez, R. Shukla, A. Tapper, K. Uchida, G.P. Uttley, L.H. Vage, T. Virdee, M. Vojinovic, N. Wardle, D. Winterbottom, K. Coldham, J.E. Cole, A. Khan, P. Kyberd, I.D. Reid, S. Abdullin, A. Brinkerhoff, B. Caraway, J. Dittmann, K. Hatakeyama, J. Hiltbrand, A.R. Kanuganti, B. McMaster, M. Saunders, S. Sawant, C. Sutantawibul, M. Toms, J. Wilson, R. Bartek, A. Dominguez, C. Huerta Escamilla, A.E. Simsek, R. Uniyal, A.M. Vargas Hernandez, R. Chudasama, S.I. Cooper, S.V. Gleyzer, C.U. Perez, P. Rumerio, E. Usai, C. West, R. Yi, A. Akpinar, A. Albert, D. Arcaro, C. Cosby, Z. Demiragli, C. Erice, E. Fontanesi, D. Gastler, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, S. Yuan, G. Benelli, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J.M. Hogan, T. Kwon, G. Landsberg, K.T. Lau, D. Li, J. Luo, S. Mondal, M. Narain, N. Pervan, S. Sagir, F. Simpson, M. Stamenkovic, W.Y. Wong, X. Yan, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P.T. Cox, R. Erbacher, G. Haza, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, B. Regnery, W. Wei, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, W.A. Nash, D. Saltzberg, B. Stone, V. Valuev, R. Clare, M. Gordon, G. Hanson, W. Si, S. Wimpenny, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, R. Gerosa, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, G. Collura, A. Dorsett, J. Incandela, M. Kilpatrick, A.J. Li, P. Masterson, H. Mei, M. Oshiro, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J.M. Lawhorn, J. Mao, H.B. Newman, T.Q. Nguyen, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, M.B. Andrews, P. Bryant, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, F. Marini, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, J. Monroy, J.R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, M.R. Adams, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, T.Á. Vámi, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, K. Wong, J. Bendavid, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, C. Fangmeier, F. Golf, J. Hossain, C. Joo, I. Kravchenko, I. Reed, J.E. Siado, G.R. Snow, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, A.G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, M. Osherson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, A. Oskin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Axion like particles, Higgs, Physics, QC1-999
Abstract: A search for an exotic decay of the Higgs boson to a Z boson and a light pseudoscalar particle (a), decaying to a pair of leptons and a pair of photons, respectively, is presented. The search is based on proton-proton collision data at a center-of-mass energy of s=13TeV, collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 138fb−1. The analysis probes pseudoscalar masses ma between 1 and 30 GeV, leading to two pairs of well-isolated leptons and photons. Upper limits at 95% confidence level are set on the Higgs boson production cross section times its branching fraction to two leptons and two photons. The observed (expected) limits are in the range of 1.1–17.8 (1.7–17.9)fb within the probed ma interval. An excess of data above the expected standard model background with a local (global) significance of 2.6 (1.3) standard deviations is observed for a mass hypothesis of ma=3GeV. Limits on models involving axion-like particles, formulated as an effective field theory, are also reported.
Published: 2024
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21. Exploring ethnic and racial differences in intraocular pressure and glaucoma: The Canadian Longitudinal Study on aging

Author: Alyssa Grant, Marie-Hélène Roy-Gagnon, Joseph Bastasic, Akshay Talekar, Garfield Miller, Gisele Li, and Ellen E. Freeman
Subjects: Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Purpose: To determine whether self-reported race/ethnicity is associated with intraocular pressure (IOP) and glaucoma and to explore whether any associations are due to social, behavioral, genetic, or health differences. Design: Cross-sectional analysis of population-based data. Methods: We used the Canadian Longitudinal Study on Aging Comprehensive Cohort, which consists of 30,097 adults aged 45–85 years. Race/ethnicity was self-reported. Corneal-compensated intraocular pressure (IOP) was measured in mmHg using the Reichert Ocular Response Analyzer. Participants were asked to report if they have ever had a diagnosis of glaucoma and whether they used eye care in the past year. A glaucoma polygenic risk score (PRS) was calculated. Logistic and linear regression models were used. Results: Black individuals had higher mean IOP levels (beta coefficient (β) = 1.46; 95% confidence interval [CI], 0.62, 2.30) while Chinese, Japanese and Korean (β = −1.00; 95% CI, −1.63, −0.38) and Southeast Asian and Filipino individuals (β = −1.56; 95% CI, −2.68, −0.43) had lower mean IOP levels as compared to White individuals after adjustment for sociodemographic, behavioral, genetic, and health-related variables. Black people were more likely to report glaucoma as compared to White people after adjustment (odds ratio [OR] = 2.43; 95% CI, 1.27, 4.64). Conclusion: Racial and ethnic differences in IOP and glaucoma were identified. Adjusting for sociodemographic, behavioral, genetic, and health-related variables did not fully explain these differences. Longitudinal research is needed to further explore the reasons for these differences and to understand their relevance to disease pathogenesis and progression.
Published: 2024
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22. Hemorrhage Evaluation and Detector System for Underserved Populations: HEADS-UP

Author: Saif Salman, MD, Qiangqiang Gu, PhD, Benoit Dherin, PhD, Sanjana Reddy, MS, Patrick Vanderboom, PhD, Rohan Sharma, MBBS, Lin Lancaster, PhD, Rabih Tawk, MD, and William David Freeman, MD
Subjects: Computer applications to medicine. Medical informatics, R858-859.7
Abstract: Objective: To create a rapid, cloud-based, and deployable machine learning (ML) method named hemorrhage evaluation and detector system for underserved populations, potentially across the Mayo Clinic enterprise, then expand to involve underserved areas and detect the 5 subtypes of intracranial hemorrhage (IH). Methods: We used Radiological Society of North America dataset for IH detection. We made 4 total iterations using Google Cloud Vertex AutoML. We trained an AutoML model with 2000 images, followed by 6000 images from both IH positive and negative classes. Pixel values were measured by the Hounsfield units, presenting a width of 80 Hounsfield and a level of 40 Hounsfield as the bone window. This was followed by a more detailed image preprocessing approach by combining the pixel values from each of the brain, subdural, and soft tissue window-based gray-scale images into R(red)-channel, G(green)-channel, and B(blue)-channel images to boost the binary IH classification performance. Four experiments with AutoML were applied to study the effects of training sample size and image preprocessing on model performance. Results: Out of the 4 AutoML experiments, the best-performing model was the fourth experiment, where 95.80% average precision, 91.40% precision, and 91.40% recall were achieved. On the basis of this analysis, our binary IH classifier hemorrhage evaluation and detector system for underserved populations appeared both accurate and performed well. Conclusion: Hemorrhage evaluation and detector system for underserved populations is a rapid, cloud-based, deployable ML method to detect IH. This tool can help expedite the care of patients with IH in resource-limited hospitals.
Published: 2023
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23. Safety and Feasibility of a Fast-Track Pathway for Neurosurgical Craniotomy Patients: Bypassing the Intensive Care Unit

Author: Carlos Perez-Vega, MD, Devang K. Sanghavi, MBBS, MD, Pablo Moreno Franco, MD, Ryan M. Chadha, MD, Alberto E. Ardon, MD, Elird Bojaxhi, MD, Klaus D. Torp, MD, Lisa A. Marshall, RN, Tiffany M. Halstead, RN, Valentino E. Ford, RN, Lynda M. Christel, Sanjeet S. Grewal, MD, Kaisorn L. Chaichana, MD, Alfredo Quinones-Hinojosa, MD, Levi W. Howard, DO, W. Christopher Fox, MD, William D. Freeman, MD, Lesia H. Mooney, CNS, APRN, Daniel J. Jerreld, Karen G. Waters, Greg Coltvet, Eric W. Nottmeier, MD, and Josephine F. Huang, MD
Subjects: Medicine (General), R5-920
Abstract: Objective: To describe the safety and feasibility of a fast-track pathway for neurosurgical craniotomy patients receiving care in a neurosciences progressive care unit (NPCU). Patients and Methods: Traditionally, most craniotomy patients are admitted to the neurosciences intensive care unit (NSICU) for postoperative follow-up. Decreased availability of NSICU beds during the coronavirus disease-2019 delta surge led our team to establish a de-novo NPCU to preserve capacity for patients requiring high level of care and would bypass routine NSICU admissions. Patients were selected a priori by treating neurosurgeons on the basis of the potential need for high-level ICU services. After operation, selected patients were transferred to the postoperative care unit, where suitability for NPCU transfer was reassessed with checklist-criteria. This process was continued after the delta surge. Results: From July 1, 2021 to September 30, 2022, 57 patients followed the NPCU protocol. Thirty-four (59.6%) were women, and the mean age was 56 years. Fifty-seven craniotomies for 34 intra-axial and 23 extra-axial lesions were performed. After assessment and application of the checklist-criteria, 55 (96.5%) were transferred to NPCU, and only 2 (3.5%) were transferred to ICU. All 55 patients followed in NPCU had good safety outcomes without requiring NSICU transfer. This saved $143,000 and led to 55 additional ICU beds for emergent admissions. Conclusion: This fast-track craniotomy protocol provides early experience that a surgeon-selected group of patients may be suitably monitored outside the traditional NSICU. This system has the potential to reduce overall health care expenses, increase capacity for NSICU bed availability, and change the paradigm of NSICU admission.
Published: 2023
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24. The impact of energy storage on the reliability of wind and solar power in New England

Author: Sergio Freeman and Ertan Agar
Subjects: Electricity demand, Energy transition, Grid integration, Long-duration energy storage (LDES), Renewable energy, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: In this study, the potential of wind and solar power to reliably meet the electricity demand of New England is evaluated, as well as the role of energy storage in improving the reliability of the region's renewable energy system. Using 44 years of hourly weather data from 1980 to 2023 obtained from the NASA MERRA-2 reanalysis product, the variability of these renewable resources and their impact on the region's electricity supply and demand is investigated. With varying mixes of wind and solar resources and sufficient resources capacity to generate electricity equal to annual demand, we find that a wind-dominant system can meet approximately 73% of the region's hourly electricity demand, whereas a solar-dominant system can only meet about 69%. However, incorporating 12 h of energy storage enhances the overall reliability of a wind-dominant system to 86%. In comparison, incorporating the same amount of energy storage in a solar-dominant system results in an overall reliability of approximately 87%. Ultimately, our analysis shows that achieving 100% reliability in meeting the annual electricity demand of New England requires addressing the mismatch between electricity demand and resource availability in terms of both location and time. This can be achieved through the integration of significant amounts of energy storage and/or wind and solar resources installations capable of generating electricity that exceeds peak demand by at least 3 times.
Published: 2024
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25. Study of azimuthal anisotropy of ϒ(1S) mesons in pPb collisions at sNN = 8.16 TeV

Author: A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F.M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E.S. Bols, J. D'Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A.R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, A. Taliercio, T.T. Tran, P. Vischia, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, S. Elgammal, A. Ellithi Kamel, M. Abdullah Al-Mashad, M.A. Mahmoud, S. Bhowmik, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, J. Ott, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, P. Jarry, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, G. Bourgatte, J.-M. Brom, E.C. Chabert, C. Collard, D. Darej, U. Goerlach, C. Grimault, A.-C. Le Bihan, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, L. Torterotot, M. Vander Donckt, P. Verdier, S. Viret, I. Lomidze, T. Toriashvili, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, M. Erdmann, P. Fackeldey, D. Fasanella, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mondal, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, H. Reithler, A. Schmidt, S.C. Schuler, A. Sharma, A. Stein, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, O. Hlushchenko, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, P. Asmuss, S. Baxter, M. Bayatmakou, O. Behnke, A. Bermúdez Martínez, S. Bhattacharya, A.A. Bin Anuar, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, L. Didukh, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, A. Grohsjean, V. Guglielmi, M. Guthoff, A. Jafari, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, M. Mormile, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, A. Saibel, M. Savitskyi, M. Scham, V. Scheurer, S. Schnake, P. Schütze, C. Schwanenberger, M. Shchedrolosiev, R.E. Sosa Ricardo, D. Stafford, N. Tonon, M. Van De Klundert, F. Vazzoler, A. Ventura Barroso, R. Walsh, D. Walter, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, K. De Leo, M. Eich, K. El Morabit, F. Feindt, A. Fröhlich, C. Garbers, E. Garutti, M. Hajheidari, J. Haller, A. Hinzmann, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, M. Rieger, O. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, R. Caspart, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, J.O. Gosewisch, A. Gottmann, F. Hartmann, M. Horzela, U. 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Strong, M. Tosi, S. Ventura, H. Yarar, M. Zanetti, P. Zotto, A. Zucchetta, G. Zumerle, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, P. Asenov, G.M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Piccinelli, M. Presilla, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Azzurri, G. Bagliesi, V. Bertacchi, R. Bhattacharya, L. Bianchini, T. Boccali, E. Bossini, D. Bruschini, R. Castaldi, M.A. Ciocci, V. D'Amante, R. Dell'Orso, M.R. Di Domenico, S. Donato, A. Giassi, F. Ligabue, G. Mandorli, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, S. Parolia, G. Ramirez-Sanchez, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, A. Scribano, N. Shafiei, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, A. Venturi, P.G. Verdini, P. Barria, M. Campana, F. Cavallari, D. Del Re, E. Di Marco, M. Diemoz, E. Longo, P. Meridiani, G. Organtini, F. Pandolfi, R. 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Parygin, V. Perelygin, V. Petrov, S. Petrushanko, S. Polikarpov, V. Popov, E. Popova, O. Radchenko, R. Ryutin, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, A. Sobol, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, S. Troshin, L. Uvarov, A. Uzunian, I. Vardanyan, E. Vlasov, A. Volkov, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, pPb, Heavy ion, v2, Upsilon, Flow, Physics, QC1-999
Abstract: The azimuthal anisotropy of Image 1 mesons in high-multiplicity proton-lead collisions is studied using data collected by the CMS experiment at a nucleon-nucleon center-of-mass energy of 8.16TeV. The Image 1 mesons are reconstructed using their dimuon decay channel. The anisotropy is characterized by the second Fourier harmonic coefficients, found using a two-particle correlation technique, in which the Image 1 mesons are correlated with charged hadrons. A large pseudorapidity gap is used to suppress short-range correlations. Nonflow contamination from the dijet background is removed using a low-multiplicity subtraction method, and the results are presented as a function of Image 1 transverse momentum. The azimuthal anisotropies are smaller than those found for charmonia in proton-lead collisions at the same collision energy, but are consistent with values found for Image 1 mesons in lead-lead interactions at a nucleon-nucleon center-of-mass energy of 5.02 TeV.
Published: 2024
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26. Measurements of azimuthal anisotropy of nonprompt D0 mesons in PbPb collisions at sNN=5.02TeV

Author: A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F.M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E.S. Bols, J. D'Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A.R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, A. Taliercio, T.T. Tran, P. Vischia, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, A.A. Abdelalim, E. Salama, M. Abdullah Al-Mashad, M.A. Mahmoud, S. Bhowmik, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, J. Ott, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, G. Bourgatte, J.-M. Brom, E.C. Chabert, C. Collard, D. Darej, U. Goerlach, C. Grimault, A.-C. Le Bihan, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, L. Torterotot, M. Vander Donckt, P. Verdier, S. Viret, I. Lomidze, T. Toriashvili, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, M. Erdmann, P. Fackeldey, D. Fasanella, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mondal, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, H. Reithler, A. Schmidt, S.C. Schuler, A. Sharma, A. Stein, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, O. Hlushchenko, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, P. Asmuss, S. Baxter, M. Bayatmakou, O. Behnke, A. Bermúdez Martínez, S. Bhattacharya, A.A. Bin Anuar, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, L. Didukh, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, A. Grohsjean, V. Guglielmi, M. Guthoff, A. Jafari, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, M. Mormile, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, A. Saibel, M. Savitskyi, M. Scham, V. Scheurer, S. Schnake, P. Schütze, C. Schwanenberger, M. Shchedrolosiev, R.E. Sosa Ricardo, D. Stafford, N. Tonon, M. Van De Klundert, F. Vazzoler, A. Ventura Barroso, R. Walsh, D. Walter, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, K. De Leo, M. Eich, K. El Morabit, F. Feindt, A. Fröhlich, C. Garbers, E. Garutti, M. Hajheidari, J. Haller, A. Hinzmann, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, M. Rieger, O. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, R. Caspart, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, J.O. Gosewisch, A. Gottmann, F. Hartmann, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, M. Link, A. Lintuluoto, S. Maier, S. Mitra, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, J. Rauser, M. Schnepf, I. Shvetsov, H.J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R.F. Von Cube, M. Wassmer, S. Wieland, R. Wolf, S. Wozniewski, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Stakia, M. Diamantopoulou, D. Karasavvas, P. Kontaxakis, A. Manousakis-Katsikakis, A. Panagiotou, I. Papavergou, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, K. Kousouris, I. Papakrivopoulos, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Csanád, K. Farkas, M.M.A. Gadallah, S. Lökös, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, O. Surányi, G.I. Veres, M. Bartók, G. Bencze, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, N. Beni, S. Czellar, J. 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Korytov, E. Kuznetsova, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, Z. Wu, T. Adams, A. Askew, N. Bower, R. Habibullah, V. Hagopian, T. Kolberg, G. Martinez, H. Prosper, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, F. Yumiceva, M.R. Adams, H. Becerril Gonzalez, R. Cavanaugh, S. Dittmer, O. Evdokimov, C.E. Gerber, D.J. Hofman, D.S. Lemos, A.H. Merrit, C. Mills, G. Oh, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, O. Amram, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, S. Kyriacou, P. Maksimovic, J. Roskes, S. Sekhar, M. Swartz, T.Á. Vámi, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, T. Isidori, J. 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Cremaldi, K. Bloom, M. Bryson, D.R. Claes, C. Fangmeier, L. Finco, F. Golf, C. Joo, R. Kamalieddin, I. Kravchenko, I. Reed, J.E. Siado, G.R. Snow, W. Tabb, A. Wightman, F. Yan, A.G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, J. Lidrych, G. Madigan, B. Marzocchi, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K.A. Hahn, Y. Liu, N. Odell, M.H. Schmitt, M. Velasco, R. Band, R. Bucci, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L.S. Durkin, B. Francis, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, S. Norberg, A.S. Bakshi, V.E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, H. Qiu, J.F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, L. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, E. Ranken, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. 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Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Chekhovsky, R. Chistov, M. Danilov, A. Demiyanov, A. Dermenev, T. Dimova, I. Dremin, V. Epshteyn, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, L. Khein, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, O. Kodolova, D. Konstantinov, V. Korenkov, V. Korotkikh, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, A. Litomin, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, I. Ovtin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, I. Vardanyan, E. Vlasov, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Heavy ions, QPG, Flow, Heavy flavor, Physics, QC1-999
Abstract: Measurements of the elliptic (v2) and triangular (v3) azimuthal anisotropy coefficients are presented for Image 1 mesons produced in Image 2 hadron decays (nonprompt Image 1 mesons) in lead-lead collisions at sNN=5.02TeV. The results are compared with previously published charm meson anisotropies measured using prompt Image 1 mesons. The data were collected with the CMS detector in 2018 with an integrated luminosity of 0.58nb−1. Azimuthal anisotropy is sensitive to the interactions of quarks with the hot and dense medium created in heavy ion collisions. Comparing results for prompt and nonprompt Image 1 mesons can assist in understanding the mass dependence of these interactions. The nonprompt results show lower magnitudes of v2 and v3 and weaker dependences on the meson transverse momentum and collision centrality than those found for prompt Image 1 mesons. The results are in agreement with theoretical predictions that include a mass dependence in the interactions of quarks with the medium.
Published: 2024
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27. Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M.A. Mahmoud, Y. Mohammed, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. Meena, G. Saha, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, A. Khvedelidze, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, U. Sarkar, V. Sarkisovi, A. Schmidt, A. Sharma, J.L. Spah, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, A. Mussgiller, L.P. Nair, A. Nürnberg, Y. Otarid, J. Park, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, M. Shchedrolosiev, R.E. Sosa Ricardo, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. Koppenhöfer, J.M. Lawhorn, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, M. Presilla, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H.J. Simonis, M. Toms, N. Trevisani, R. Ulrich, R.F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, S. Wunsch, X. Zuo, G. Anagnostou, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M.M.A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, G.I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S.B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, A. Kaur, H. Kaur, M. Kaur, S. Kumar, K. Sandeep, T. Sheokand, J.B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B.C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Baradia, S. Barman, S. Dutta, P. Palit, S. Sarkar, M.M. Ameen, P.K. Behera, S.C. Behera, P. Jana, P. Kalbhor, J.R. Komaragiri, D. Kumar, L. Panwar, P.R. Pujahari, N.R. Saha, A.K. Sikdar, S. Verma, S. Dugad, M. Kumar, G.B. Mohanty, P. Suryadevara, A. Bala, S. Banerjee, R.M. Chatterjee, M. Guchait, Sh. Jain, S. Karmakar, G. Majumder, K. Mazumdar, S. Parolia, A. Thachayath, S. Bahinipati, A.K. Das, C. Kar, D. Maity, P. Mal, T. Mishra, V.K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, P. Sadangi, P. Saha, S.K. Swain, S. Varghese, D. Vats, S. Acharya, A. Alpana, S. Dube, B. Gomber, B. Kansal, A. Laha, B. Sahu, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S.M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, A. Colaleo, D. Creanza, B. D'Anzi, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, L. Fiore, G. Iaselli, M. Louka, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, G. Ramirez-Sanchez, D. Ramos, A. Ranieri, L. Silvestris, F.M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, R. Campanini, P. Capiluppi, A. Castro, F.R. Cavallo, M. Cuffiani, G.M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, C. Grandi, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F.L. Navarria, A. Perrotta, F. Primavera, A.M. Rossi, G.P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, P. Assiouras, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D'Alessandro, E. Focardi, T. Kello, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, A. Papanastassiou, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, G. Boldrini, F. Brivio, F. Cetorelli, F. De Guio, M.E. Dinardo, P. Dini, S. Gennai, R. Gerosa, A. Ghezzi, P. Govoni, L. Guzzi, M.T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, B.S. Pinolini, S. Ragazzi, T. Tabarelli de Fatis, D. Zuolo, S. Buontempo, A. Cagnotta, F. Carnevali, N. Cavallo, A. De Iorio, F. Fabozzi, A.O.M. Iorio, L. Lista, P. Paolucci, B. Rossi, C. Sciacca, R. Ardino, P. Azzi, N. Bacchetta, D. Bisello, P. Bortignon, A. Bragagnolo, R. Carlin, P. Checchia, T. Dorigo, F. Fanzago, U. Gasparini, F. Gonella, E. Lusiani, M. Margoni, M. Migliorini, J. Pazzini, P. Ronchese, R. Rossin, F. Simonetto, G. Strong, M. Tosi, A. Triossi, S. Ventura, H. Yarar, M. Zanetti, P. Zotto, A. Zucchetta, G. Zumerle, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, S. Ajmal, P. Asenov, G.M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Azzurri, G. Bagliesi, R. Bhattacharya, L. Bianchini, T. Boccali, E. Bossini, D. Bruschini, R. Castaldi, M.A. Ciocci, M. Cipriani, V. D'Amante, R. Dell'Orso, S. Donato, A. Giassi, F. Ligabue, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, A. Scribano, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, A. Venturi, P.G. Verdini, P. Barria, M. Campana, F. Cavallari, L. Cunqueiro Mendez, D. Del Re, E. Di Marco, M. Diemoz, F. Errico, E. Longo, P. Meridiani, J. Mijuskovic, G. Organtini, F. Pandolfi, R. Paramatti, C. Quaranta, S. Rahatlou, C. Rovelli, F. Santanastasio, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, N. Bartosik, R. Bellan, A. Bellora, C. Biino, N. Cartiglia, M. Costa, R. Covarelli, N. Demaria, L. Finco, M. Grippo, B. Kiani, F. Legger, F. Luongo, C. Mariotti, S. Maselli, A. Mecca, E. Migliore, M. Monteno, R. Mulargia, M.M. Obertino, G. Ortona, L. Pacher, N. Pastrone, M. Pelliccioni, M. Ruspa, F. Siviero, V. Sola, A. Solano, A. Staiano, C. Tarricone, D. Trocino, G. Umoret, E. Vlasov, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, K. De Leo, G. Della Ricca, S. Dogra, J. Hong, C. Huh, B. Kim, D.H. Kim, J. Kim, H. Lee, S.W. Lee, C.S. Moon, Y.D. Oh, M.S. Ryu, S. Sekmen, Y.C. Yang, M.S. Kim, G. Bak, P. Gwak, H. Kim, D.H. Moon, E. Asilar, D. Kim, T.J. Kim, J.A. Merlin, S. Choi, S. Han, B. Hong, K.S. Lee, S. Lee, S.K. Park, J. Yoo, J. Goh, S. Yang, H.S. Kim, Y. Kim, J. Almond, J.H. Bhyun, W. Jun, J.S. Kim, S. Ko, H. Kwon, J. Lee, B.H. Oh, S.B. Oh, H. Seo, U.K. Yang, I. Yoon, W. Jang, D.Y. Kang, Y. Kang, S. Kim, B. Ko, J.S.H. Lee, Y. Lee, I.C. Park, Y. Roh, I.J. Watson, S. Ha, H.D. Yoo, M. Choi, M.R. Kim, I. Yu, T. Beyrouthy, Y. Maghrbi, K. Dreimanis, A. Gaile, G. Pikurs, A. Potrebko, M. Seidel, V. Veckalns, N.R. Strautnieks, M. Ambrozas, A. Juodagalvis, A. Rinkevicius, G. Tamulaitis, N. Bin Norjoharuddeen, I. Yusuff, Z. Zolkapli, J.F. Benitez, A. Castaneda Hernandez, H.A. Encinas Acosta, L.G. Gallegos Maríñez, M. León Coello, J.A. Murillo Quijada, A. Sehrawat, L. Valencia Palomo, G. Ayala, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-De La Cruz, R. Lopez-Fernandez, C.A. Mondragon Herrera, A. Sánchez Hernández, C. Oropeza Barrera, M. Ramírez García, I. Bautista, I. Pedraza, H.A. Salazar Ibarguen, C. Uribe Estrada, I. Bubanja, N. Raicevic, P.H. Butler, A. Ahmad, M.I. Asghar, A. Awais, M.I.M. Awan, H.R. Hoorani, W.A. Khan, V. Avati, L. Grzanka, M. Malawski, H. Bialkowska, M. Bluj, B. Boimska, M. Górski, M. Kazana, M. Szleper, P. Zalewski, K. Bunkowski, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, A. Muhammad, K. Pozniak, W. Zabolotny, M. Araujo, D. Bastos, C. Beirão Da Cruz E Silva, A. Boletti, M. Bozzo, T. Camporesi, G. Da Molin, P. Faccioli, M. Gallinaro, J. Hollar, N. Leonardo, T. Niknejad, A. Petrilli, M. Pisano, J. Seixas, J. Varela, J.W. Wulff, P. Adzic, P. Milenovic, M. Dordevic, J. Milosevic, V. Rekovic, M. Aguilar-Benitez, J. Alcaraz Maestre, Cristina F. Bedoya, M. Cepeda, M. Cerrada, N. Colino, B. De La Cruz, A. Delgado Peris, A. Escalante Del Valle, D. Fernández Del Val, J.P. Fernández Ramos, J. Flix, M.C. Fouz, O. Gonzalez Lopez, S. Goy Lopez, J.M. Hernandez, M.I. Josa, D. Moran, C.M. Morcillo Perez, Á. Navarro Tobar, C. Perez Dengra, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, I. Redondo, D.D. Redondo Ferrero, L. Romero, S. Sánchez Navas, L. Urda Gómez, J. Vazquez Escobar, C. Willmott, J.F. de Trocóniz, B. Alvarez Gonzalez, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, J.R. González Fernández, E. Palencia Cortezon, C. Ramón Álvarez, V. Rodríguez Bouza, A. Soto Rodríguez, A. Trapote, C. Vico Villalba, P. Vischia, S. Bhowmik, S. Blanco Fernández, J.A. 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Mersi, E. Meschi, V. Milosevic, F. Monti, F. Moortgat, M. Mulders, I. Neutelings, S. Orfanelli, F. Pantaleo, G. Petrucciani, A. Pfeiffer, M. Pierini, D. Piparo, H. Qu, D. Rabady, G. Reales Gutiérrez, M. Rovere, H. Sakulin, S. Scarfi, C. Schwick, M. Selvaggi, K. Shchelina, P. Silva, P. Sphicas, A.G. Stahl Leiton, A. Steen, S. Summers, D. Treille, P. Tropea, A. Tsirou, D. Walter, J. Wanczyk, S. Wuchterl, P. Zehetner, P. Zejdl, W.D. Zeuner, T. Bevilacqua, L. Caminada, A. Ebrahimi, W. Erdmann, R. Horisberger, Q. Ingram, H.C. Kaestli, D. Kotlinski, C. Lange, M. Missiroli, L. Noehte, T. Rohe, T.K. Aarrestad, K. Androsov, M. Backhaus, A. Calandri, C. Cazzaniga, K. Datta, A. De Cosa, G. Dissertori, M. Dittmar, M. Donegà, F. Eble, M. Galli, K. Gedia, F. Glessgen, C. Grab, D. Hits, W. Lustermann, A.-M. Lyon, R.A. Manzoni, M. Marchegiani, L. Marchese, C. Martin Perez, A. Mascellani, F. Nessi-Tedaldi, F. Pauss, V. Perovic, S. Pigazzini, M. Reichmann, C. Reissel, T. Reitenspiess, B. Ristic, F. 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Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, A. Bethani, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Top quarks, Extra Higgs boson, Yukawa couplings, Physics, QC1-999
Abstract: A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp→tH/A→ttc‾ and pp→tH/A→ttu‾ processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138fb−1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200–1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.
Published: 2024
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28. Equity of overdose education and naloxone distribution provided in the Kentucky HEALing Communities Study

Author: Douglas R. Oyler, Hannah K. Knudsen, Carrie B. Oser, Sharon L. Walsh, Monica Roberts, Shawn R. Nigam, Philip M. Westgate, and Patricia R. Freeman
Subjects: Naloxone, Overdose, Health equity, Medicine
Abstract: Background: Opioid overdoses differentially affect demographic groups. Strategies to reduce overdose deaths, specifically overdose education and naloxone distribution (OEND), are not consistently delivered equitably. Methods: The HEALing Communities StudySM (HCS) is a cluster-randomized trial designed to implement evidence-based practices, including OEND, to reduce overdose deaths across communities. Individuals receiving OEND in eight Kentucky counties between January 2020 and June 2022 provided demographics and overdose history. Recipient characteristics were compared to opioid overdose decedent characteristics to evaluate whether OEND was equitably delivered to the target population. Recipient characteristics were also analyzed based on whether OEND was delivered in criminal justice, behavioral health, or health care facilities. Results: A total of 26,273 demographic records were analyzed from 137 partner agencies. Most agencies were in behavioral health (85.6 %) or criminal justice sectors (10.4 %). About half of OEND recipients were male (50.6 %), which was significantly lower than the 70.3 % of overdose decedents who were male, (p
Published: 2024
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29. Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes

Author: Dante Barreda, Sergio Grinstein, and Spencer A. Freeman
Subjects: Niemann-Pick type C1 (NPC1), Niemann-Pick type C2 (NPC2), Phagocytosis, Autophagy, V-ATPase, Lysosome, Cytology, QH573-671
Abstract: The ongoing phagocytic activity of macrophages necessitates an extraordinary capacity to digest and resolve incoming material. While the initial steps leading to the formation of a terminal phagolysosome are well studied, much less is known about the later stages of this process, namely the degradation and resolution of the phagolysosomal contents. We report that the degradation of targets such as splenocytes and erythrocytes by phagolysosomes occurs in a stepwise fashion, requiring lysis of their plasmalemmal bilayer as an essential initial step. This is achieved by the direct extraction of cholesterol facilitated by Niemann-Pick protein type C2 (NPC2), which in turn hands off cholesterol to NPC1 for export from the phagolysosome. The removal of cholesterol ulimately destabilizes and permeabilizes the membrane of the phagocytic target, allowing access of hydrolases to its internal compartments. In contrast, we found that saposins, which activate the hydrolysis of sphingolipids, are required for lysosomal tubulation, yet are dispensable for the resolution of targets by macrophages. The extraction of cholesterol by NPC2 is therefore envisaged as rate-limiting in the clearance of membrane-bound targets such as apoptotic cells. Selective cholesterol removal appears to be a primary mechanism that enables professional phagocytes to distinguish the target membrane from the phagolysosomal membrane and may be conserved in the resolution of autolysosomes.
Published: 2024
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30. Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model

Author: Yufei Wang, Jae-Won Cho, Gabriella Kastrunes, Alicia Buck, Cecile Razimbaud, Aedin C. Culhane, Jiusong Sun, David A. Braun, Toni K. Choueiri, Catherine J. Wu, Kristen Jones, Quang-De Nguyen, Zhu Zhu, Kevin Wei, Quan Zhu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, and Wayne A. Marasco
Subjects: Immunology, Cancer, Transcriptomics, Science
Abstract: Summary: One of the major barriers that have restricted successful use of chimeric antigen receptor (CAR) T cells in the treatment of solid tumors is an unfavorable tumor microenvironment (TME). We engineered CAR-T cells targeting carbonic anhydrase IX (CAIX) to secrete anti-PD-L1 monoclonal antibody (mAb), termed immune-restoring (IR) CAR G36-PDL1. We tested CAR-T cells in a humanized clear cell renal cell carcinoma (ccRCC) orthotopic mouse model with reconstituted human leukocyte antigen (HLA) partially matched human leukocytes derived from fetal CD34+ hematopoietic stem cells (HSCs) and bearing human ccRCC skrc-59 cells under the kidney capsule. G36-PDL1 CAR-T cells, haploidentical to the tumor cells, had a potent antitumor effect compared to those without immune-restoring effect. Analysis of the TME revealed that G36-PDL1 CAR-T cells restored active antitumor immunity by promoting tumor-killing cytotoxicity, reducing immunosuppressive cell components such as M2 macrophages and exhausted CD8+ T cells, and enhancing T follicular helper (Tfh)-B cell crosstalk.
Published: 2024
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31. Brazilin is a natural product inhibitor of the NLRP3 inflammasome

Author: Emily McMahon, Sherihan El-Sayed, Jack Green, Christopher Hoyle, Lorna FitzPatrick, Emma V. Jones, Eve Corrie, Rebecca L. Kelly, Mairi Challinor, Sally Freeman, Richard A. Bryce, Catherine B. Lawrence, David Brough, and Paul R. Kasher
Subjects: Biological sciences, Biochemistry, Biomolecules, Natural product biochemistry, Science
Abstract: Summary: Excessive or aberrant NLRP3 inflammasome activation has been implicated in the progression and initiation of many inflammatory conditions; however, currently no NLRP3 inflammasome inhibitors have been approved for therapeutic use in the clinic. Here we have identified that the natural product brazilin effectively inhibits both priming and activation of the NLRP3 inflammasome in cultured murine macrophages, a human iPSC microglial cell line and in a mouse model of acute peritoneal inflammation. Through computational modeling, we predict that brazilin can adopt a favorable binding pose within a site of the NLRP3 protein which is essential for its conformational activation. Our results not only encourage further evaluation of brazilin as a therapeutic agent for NLRP3-related inflammatory diseases, but also introduce this small-molecule as a promising scaffold structure for the development of derivative NLRP3 inhibitor compounds.
Published: 2024
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32. Prevalence of chronic cough, its risk factors and population attributable risk in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional studyResearch in context

Author: Hazim Abozid, Jaymini Patel, Peter Burney, Sylvia Hartl, Robab Breyer-Kohansal, Kevin Mortimer, Asaad A. Nafees, Mohammed Al Ghobain, Tobias Welte, Imed Harrabi, Meriam Denguezli, Li Cher Loh, Abdul Rashid, Thorarinn Gislason, Cristina Barbara, Joao Cardoso, Fatima Rodrigues, Terence Seemungal, Daniel Obaseki, Sanjay Juvekar, Stefanni Nonna Paraguas, Wan C. Tan, Frits M.E. Franssen, Filip Mejza, David Mannino, Christer Janson, Hamid Hacene Cherkaski, Mahesh Padukudru Anand, Hasan Hafizi, Sonia Buist, Parvaiz A. Koul, Asma El Sony, Marie-Kathrin Breyer, Otto C. Burghuber, Emiel F.M. Wouters, Andre F.S. Amaral, Anila Aliko, Donika Bardhi, Holta Tafa, Natasha Thanasi, Arian Mezini, Alma Teferici, Dafina Todri, Jolanda Nikolla, Rezarta Kazasi, Amira Bengrait, Tabarek Haddad, Ibtissem Zgaoula, Maamar Ghit, Abdelhamid Roubhia, Soumaya Boudra, Feryal Atoui, Randa Yakoubi, Rachid Benali, Abdelghani Bencheikh, Nadia Ait-Khaled, Christine Jenkins, Guy Marks, Tessa Bird, Paola Espinel, Kate Hardaker, Brett Toelle, Michael Studnicka, Torkil Dawes, Bernd Lamprecht, Lea Schirhofer, Akramul Islam, Syed Masud Ahmed, Shayla Islam, Qazi Shafayetul Islam, Mesbah-Ul-Haque, Tridib Roy Chowdhury, Sukantha Kumar Chatterjee, Dulal Mia, Shyamal Chandra Das, Mizanur Rahman, Nazrul Islam, Shahaz Uddin, Nurul Islam, Luiza Khatun, Monira Parvin, Abdul Awal Khan, Maidul Islam, Herve Lawin, Arsene Kpangon, Karl Kpossou, Gildas Agodokpessi, Paul Ayelo, Benjamin Fayomi, Bertrand Mbatchou, Atongno Humphrey Ashu, Wen Wang, NanShan Zhong, Shengming Liu, Jiachun Lu, Pixin Ran, Dali Wang, Jin-ping Zheng, Yumin Zhou, Rain Jogi, Hendrik Laja, Katrin Ulst, Vappu Zobel, Toomas-Julius Lill, Ayola Akim Adegnika, Isabelle Bodemann, Henning Geldmacher, Alexandra SchwedaLinow, Bryndis Benedikdtsdottir, Kristin Jorundsdottir, Lovisa Gudmundsdottir, Sigrun Gudmundsdottir, Gunnar Gudmundsson, Mahesh Rao, Sajjad Malik, Nissar A. Hakim, Umar Hafiz Khan, Rohini Chowgule, Vasant Shetye, Jonelle Raphael, Rosel Almeda, Mahesh Tawde, Rafiq Tadvi, Sunil Katkar, Milind Kadam, Rupesh Dhanawade, Umesh Ghurup, Siddhi Hirve, Somnath Sambhudas, Bharat Chaidhary, Meera Tambe, Savita Pingale, Arati Umap, Archana Umap, Nitin Shelar, Sampada Devchakke, Sharda Chaudhary, Suvarna Bondre, Savita Walke, Ashleshsa Gawhane, Anil Sapkal, Rupali Argade, Vijay Gaikwad, Sundeep Salvi, Bill Brashier, Jyoti Londhe, Sapna Madas, Althea Aquart-Stewart, Akosua Francia Aikman, Talant M. Sooronbaev, Bermet M. Estebesova, Meerim Akmatalieva, Saadat Usenbaeva, Jypara Kydyrova, Eliza Bostonova, Ulan Sheraliev, Nuridin Marajapov, Nurgul Toktogulova, Berik Emilov, Toktogul Azilova, Gulnara Beishekeeva, Nasyikat Dononbaeva, Aijamal Tabyshova, Wezzie Nyapigoti, Ernest Mwangoka, Mayamiko Kambwili, Martha Chipeta, Gloria Banda, Suzgo Mkandawire, Justice Banda, Li-Cher Loh, Siti Sholehah, Mohamed C. Benjelloun, Chakib Nejjari, Mohamed Elbiaze, Karima El Rhazi, E.F.M. Wouters, G.J. Wesseling, Gregory Erhabor, Olayemi Awopeju, Olufemi Adewole, Amund Gulsvik, Tina Endresen, Lene Svendsen, Muhammad Irfan, Zafar Fatmi, Aysha Zahidie, Natasha Shaukat, Meesha Iqbal, Luisito F. Idolor, Teresita S. de Guia, Norberto A. Francisco, Camilo C. Roa, Fernando G. Ayuyao, Cecil Z. Tady, Daniel T. Tan, Sylvia Banal-Yang, Vincent M. Balanag, Jr., Maria Teresita N. Reyes, Renato B. Dantes, Lourdes Amarillo, Lakan U. Berratio, Lenora C. Fernandez, Gerard S. Garcia, Sullian S. Naval, Thessa Reyes, Camilo C. Roa, Jr., Flordeliza Sanchez, Leander P. Simpao, Ewa Nizankowska-Mogilnicka, Jakub Frey, Rafal Harat, Pawel Nastalek, Andrzej Pajak, Wojciech Skucha, Andrzej Szczeklik, Magda Twardowska, Herminia Dias, João Almeida, Maria Joao Matos, Paula Simão, Moutinho Santos, Reis Ferreira, M. Al Ghobain, H. Alorainy, E. El-Hamad, M. Al Hajjaj, A. Hashi, R. Dela, R. Fanuncio, E. Doloriel, I. Marciano, L. Safia, Eric Bateman, Anamika Jithoo, Desiree Adams, Edward Barnes, Jasper Freeman, Anton Hayes, Sipho Hlengwa, Christine Johannisen, Mariana Koopman, Innocentia Louw, Ina Ludick, Alta Olckers, Johanna Ryck, Janita Storbeck, Kirthi Gunasekera, Rajitha Wickremasinghe, Asma Elsony, Hana A. Elsadig, Nada Bakery Osman, Bandar Salah Noory, Monjda Awad Mohamed, Hasab Alrasoul Akasha Ahmed Osman, Namarig Moham ed Elhassan, Abdel Mu’is El Zain, Marwa Mohamed Mohamaden, Suhaiba Khalifa, Mahmoud Elhadi, Mohand Hassan, Dalia Abdelmonam, Inga Sif Olafsdottir, Katarina Nisser, Ulrike SpetzNystrom, Gunilla Hagg, GunMarie Lund, Fallon Lutchmansingh, Liane Conyette, Myriam Denguezli, Zouhair Tabka, Hager Daldoul, Zaki Boukheroufa, Firas Chouikha, Wahbi Belhaj Khalifa, Ali Kocabas, Attila Hancioglu, Ismail Hanta, Sedat Kuleci, Ahmet Sinan Turkyilmaz, Sema Umut, Turgay Unalan, Peter G.J. Burney, Louisa Gnatiuc, Hadia Azar, Caron Amor, James Potts, Michael Tumilty, Fiona McLean, Risha Dudhaiya, A. Sonia Buist, Mary Ann McBurnie, William M. Vollmer, Suzanne Gillespie, Sean Sullivan, Todd A. Lee, Kevin B. Weiss, Robert L. Jensen, Robert Crapo, Paul Enright, David M. Mannino, John Cain, Rebecca Copeland, Dana Hazen, and Jennifer Methvin
Subjects: Chronic cough, Epidemiology, Global health, Excess risk, Medicine (General), R5-920
Abstract: Summary: Background: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a standardised protocol and definition. Methods: We analysed cross-sectional data from 33,983 adults (≥40 years), recruited between Jan 2, 2003 and Dec 26, 2016, in 41 sites (34 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We estimated the prevalence of chronic cough for each site accounting for sampling design. To identify risk factors, we conducted multivariable logistic regression analysis within each site and then pooled estimates using random-effects meta-analysis. We also calculated the population attributable risk (PAR) associated with each of the identifed risk factors. Findings: The prevalence of chronic cough varied from 3% in India (rural Pune) to 24% in the United States of America (Lexington,KY). Chronic cough was more common among females, both current and passive smokers, those working in a dusty job, those with a history of tuberculosis, those who were obese, those with a low level of education and those with hypertension or airflow limitation. The most influential risk factors were current smoking and working in a dusty job. Interpretation: Our findings suggested that the prevalence of chronic cough varies widely across sites in different world regions. Cigarette smoking and exposure to dust in the workplace are its major risk factors. Funding: Wellcome Trust.
Published: 2024
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33. Structural metamaterial lattices by laser powder-bed fusion of 17-4PH steel

Author: Felicity S.H.B. Freeman, Luke M. Jones, Alexander D. Goodall, Hassan Ghadbeigi, and Iain Todd
Subjects: Structural metamaterial, Martensitic transformation, Additive manufacturing, Laser powder bed fusion, Mechanically graded, Industrial engineering. Management engineering, T55.4-60.8
Abstract: Additive manufacturing build parameters are used to engineer structural metamaterials lattices with controllable mechanical performance, achieved through microstructural grading of 17-4PH steel without compositional or geometric modification. The high solidification rates of laser powder-bed fusion suppress the thermal martensitic transformation and lead to elevated levels of retained austenite. Diamond cubic lattices built at low energy density (low thermal strain) retain a low martensite phase fraction (3 wt%) and exhibit a bend-dominated compression response. Lattices built at high energy density experience increased thermal strain during the build, causing in-situ deformation-driven transformation, yielding 44 wt% martensite; these exhibit a stretch-dominated compression response. Metamaterial lattices, with high and low energy density parameters in different configurations, exhibit mixed compression responses. Controllable mechanical response was achieved through control of microstructure, using build parameters to adjust thermal strain and selectively suppress or trigger the martensitic phase transformation in-situ.
Published: 2024
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34. P212: Modifiers of arterial stenosis in Williams syndrome: Using genomics to discover drivers of vessel-specific outcomes

Author: Ashley Golbus, Delong Liu, Mark Levin, Neelam Raja, Elisa Biamino, Maria Bedeschi, Maria Digilio, Gabriella Squeo, Roberta Villa, Joy Lynne Freeman, Sharon Osgood, Giuseppe Merla, Barbara Pober, Carolyn Mervis, Amy Roberts, Colleen Morris, Lucy Osborne, and Beth Kozel
Subjects: Genetics, QH426-470, Medicine
Published: 2024
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35. Application of machine learning approach for iron deficiency anaemia detection in children using conjunctiva images

Author: Justice Williams Asare, William Leslie Brown-Acquaye, Martin Mabeifam Ujakpa, Emmanuel Freeman, and Peter Appiahene
Subjects: Iron deficiency, CIELAB colour space, Non-invasive, Invasive, Algorithms, Anaemia, Computer applications to medicine. Medical informatics, R858-859.7
Abstract: Iron deficiency is commonly referred to as anaemia which is a general public health problem that normally occurs as a result of a reduction in red blood cells which is common in developing countries such as Africa. In this study, machine learning algorithms such as CNN, k-NN, Naïve Bayes, Decision Tree and SVM were utilized for the study to detect anaemia in children using conjunctiva images. The images were segmented into their various CIELAB colour space components and the ROI from each image was retrieved. The dataset was split randomly into 70:10:20, which were then used to train, validate, and test the models, as appropriate. The CNN achieved the highest accuracy (98.45 %). The findings of this study demonstrate that non-invasive techniques are essential for detecting anaemia in children. This study deploys a cost-effective mechanism, and result-orientated, to detect anaemia in developing communities where health facilities, resources, and personnel are scarce.
Published: 2024
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36. Household welfare outcomes of access to and use of agricultural radio broadcast by women cocoa farmers in Tepa district, Ghana

Author: Roland Awuah-Frimpong, Enoch Kwame Tham-Agyekum, Fred Ankuyi, Comfort Freeman, Festus Annor-Frempong, and John-Eudes Andivi Bakang
Subjects: Access, Agriculture, Cocoa farmers, Household welfare, Radio, History of scholarship and learning. The humanities, AZ20-999, Social sciences (General), H1-99
Abstract: Ghanaian women play a significant part in the country's agricultural marketing, processing and production, yet the gender information gap is severe. This survey aimed to evaluate women's access to and use of agriculture radio broadcasts in the Ashanti Region's Tepa district, Ghana. A descriptive research design and quantitative research method were employed, with a sample size of 300 determined using Cochran's formula. The results indicate that women cocoa farmers have high access to and use cocoa-related information through radio broadcasts. Socio-economic factors such as age, ownership of radio sets, cooperative membership, farm size, and land tenure system significantly affect women's level of access and use of cocoa-related information from radio broadcasts. Women cocoa farmers who utilize the information received from radio broadcasts have improved their household welfare; income, productivity, and livelihood assets. Poor radio signals, lack of finance, and inconvenient broadcast times for women farmers were found to be the most severe constraints. To improve women's household welfare, government agencies should pay more attention to women's information needs.
Published: 2024
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37. Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise

Author: Lena E. Trager, Margaret Lyons, Alexandra Kuznetsov, Cedric Sheffield, Kangsan Roh, Rebecca Freeman, James Rhee, J. Sawalla Guseh, Haobo Li, and Anthony Rosenzweig
Subjects: Angiogenesis, Cardiac fibrosis, Cardioprotection, Hypertrophy, Non-cardiomyocytes, Proliferation, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract: Cardiomyocytes comprise ∼70% to 85% of the total volume of the adult mammalian heart but only about 25% to 35% of its total number of cells. Advances in single cell and single nuclei RNA sequencing have greatly facilitated investigation into and increased appreciation of the potential functions of non-cardiomyocytes in the heart. While much of this work has focused on the relationship between non-cardiomyocytes, disease, and the heart's response to pathological stress, it will also be important to understand the roles that these cells play in the healthy heart, cardiac homeostasis, and the response to physiological stress such as exercise. The present review summarizes recent research highlighting dynamic changes in non-cardiomyocytes in response to the physiological stress of exercise. Of particular interest are changes in fibrotic pathways, the cardiac vasculature, and immune or inflammatory cells. In many instances, limited data are available about how specific lineages change in response to exercise or whether the changes observed are functionally important, underscoring the need for further research.
Published: 2023
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38. Firefighting and Cancer: A Meta-analysis of Cohort Studies in the Context of Cancer Hazard Identification

Author: Nathan L. DeBono, Robert D. Daniels, Laura E. Beane Freeman, Judith M. Graber, Johnni Hansen, Lauren R. Teras, Tim Driscoll, Kristina Kjaerheim, Paul A. Demers, Deborah C. Glass, David Kriebel, Tracy L. Kirkham, Roland Wedekind, Adalberto M. Filho, Leslie Stayner, and Mary K. Schubauer-Berigan
Subjects: Cancer, Firefighter, Hazard, Public aspects of medicine, RA1-1270
Abstract: Objective: We performed a meta-analysis of epidemiological results for the association between occupational exposure as a firefighter and cancer as part of the broader evidence synthesis work of the IARC Monographs program. Methods: A systematic literature search was conducted to identify cohort studies of firefighters followed for cancer incidence and mortality. Studies were evaluated for the influence of key biases on results. Random-effects meta-analysis models were used to estimate the association between ever-employment and duration of employment as a firefighter and risk of 12 selected cancers. The impact of bias was explored in sensitivity analyses. Results: Among the 16 included cancer incidence studies, the estimated meta-rate ratio, 95% confidence interval (CI), and heterogeneity statistic (I2) for ever-employment as a career firefighter compared mostly to general populations were 1.58 (1.14–2.20, 8%) for mesothelioma, 1.16 (1.08–1.26, 0%) for bladder cancer, 1.21 (1.12–1.32, 81%) for prostate cancer, 1.37 (1.03–1.82, 56%) for testicular cancer, 1.19 (1.07–1.32, 37%) for colon cancer, 1.36 (1.15–1.62, 83%) for melanoma, 1.12 (1.01–1.25, 0%) for non-Hodgkin lymphoma, 1.28 (1.02–1.61, 40%) for thyroid cancer, and 1.09 (0.92–1.29, 55%) for kidney cancer. Ever-employment as a firefighter was not positively associated with lung, nervous system, or stomach cancer. Results for mesothelioma and bladder cancer exhibited low heterogeneity and were largely robust across sensitivity analyses. Conclusions: There is epidemiological evidence to support a causal relationship between occupational exposure as a firefighter and certain cancers. Challenges persist in the body of evidence related to the quality of exposure assessment, confounding, and medical surveillance bias.
Published: 2023
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39. Disseminated mycobacterial infections after tumor necrosis factor inhibitor use, revealing inborn errors of immunity

Author: Jacqueline D. Squire, Claudia R. Libertin, Harry Powers, Jared Nelson, Lisa Brumble, Federico R. Laham, Anahita Agharahimi, Alexandra F. Freeman, and Jennifer W. Leiding
Subjects: Mycobacteria, Inborn errors of immunity, TNF inhibitor, Infliximab, Immunodeficiency, Infectious and parasitic diseases, RC109-216
Abstract: Tumor necrosis factor-a inhibitors can be associated with increased risk of infections, particularly reactivation of latent tuberculosis or nontuberculous mycobacterium (NTM). However, because disseminated NTM is rare, inborn errors of immunity should be considered. We present three patients with disseminated NTM after tumor necrosis factor-a inhibitor use who were found to have inborn errors of immunity.
Published: 2023
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40. A scoping review of health system guidelines for pharmacist responsibilities when dispensing opioids

Author: William Manning Olsen, Chris Freeman, Adeleke Adewumi, and Adam La Caze
Subjects: Opioid, Dispensing, Pharmacist, Pharmacy, Responsibility, Pharmacy and materia medica, RS1-441
Abstract: Introduction: Prescription opioid use and evidence of the harm caused by these medicines has increased over the past 20–30 years. Despite a number of system level interventions, the opioid crisis has not yet resolved in Australia or globally. Pharmacists are increasingly required to take a proactive, clinical role to fulfil their responsibility for patient outcomes relating to both medication efficacy and safety. Aim: To evaluate the current health system guidelines available to pharmacists dispensing opioids and to examine the implications of this guidance on pharmacist responsibility. Methods: A scoping review was conducted by searching in CINAHL, MEDLINE, Embase, PubMed and Web of Science, in addition to the grey literature and referral from topic experts to collate a list of current health system guidelines relevant to pharmacists dispensing opioids. These guidelines were then examined through thematic analysis and the use of the “Appraisal of Guidelines Research & Evaluation—Health Systems” tool (AGREE-HS). Results: Ten health system guidelines were identified in the search. Identified guidelines were published in Australia, the United States, and the United Kingdom. Health system guidelines analysed in this study most commonly provide general practice statements that are not specific to opioid medicines. Current guidelines frequently recommend risk assessment, but less commonly provide implementable risk mitigation advice. Additionally, guidelines are of poor overall quality when analysed through metrics relating to their development and implementation. Conclusion: There are gaps in current health system guidelines which contribute to perceived barriers in pharmacy practice. Current health system guidance does not provide a clear account of the responsibilities of pharmacists when dispensing opioids. This study provides an argument for the development of implementable health system guidelines that support pharmacists in taking direct responsibility for patient outcomes when dispensing opioid medicines.
Published: 2023
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41. Observation of four top quark production in proton-proton collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, M. Mittal, L. Yuan, G. Bauer, Z. Hu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, F. Monti, M.A. Shahzad, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, C. Zhou, Z. You, N. Lu, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, A.A. Abdelalim, E. Salama, A. Lotfy, M.A. Mahmoud, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, M. Vander Donckt, P. Verdier, J. Xiao, G. Adamov, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, S.C. Schuler, A. Sharma, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. 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Fontanesi, D. Gastler, S. Jeon, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, S. Yuan, G. Benelli, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J.M. Hogan, T. Kwon, G. Landsberg, K.T. Lau, D. Li, J. Luo, S. Mondal, M. Narain, N. Pervan, S. Sagir, F. Simpson, M. Stamenkovic, W.Y. Wong, X. Yan, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P.T. Cox, R. Erbacher, G. Haza, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, W. Wei, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, W.A. Nash, D. Saltzberg, B. Stone, V. Valuev, R. Clare, M. Gordon, G. Hanson, W. Si, S. Wimpenny, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, R. Gerosa, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, G. Collura, A. Dorsett, J. Incandela, M. Kilpatrick, A.J. Li, P. Masterson, H. Mei, M. Oshiro, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J.M. Lawhorn, J. Mao, H.B. Newman, T.Q. Nguyen, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, M.B. Andrews, P. Bryant, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, F. Marini, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, J. Monroy, J.R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, M.R. Adams, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, T.Á. Vámi, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, K. Wong, J. Bendavid, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, C. Fangmeier, F. Golf, J. Hossain, C. Joo, I. Kravchenko, I. Reed, J.E. Siado, G.R. Snow, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, A.G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, R. Band, R. Bucci, S. Castells, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, H. Nelson, M. Osherson, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, T. Holmes, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Top quark, Physics, QC1-999
Abstract: The observation of the production of four top quarks in proton-proton collisions is reported, based on a data sample collected by the CMS experiment at a center-of-mass energy of 13 TeV in 2016–2018 at the CERN LHC and corresponding to an integrated luminosity of 138fb−1. Events with two same-sign, three, or four charged leptons (electrons and muons) and additional jets are analyzed. Compared to previous results in these channels, updated identification techniques for charged leptons and jets originating from the hadronization of b quarks, as well as a revised multivariate analysis strategy to distinguish the signal process from the main backgrounds, lead to an improved expected signal significance of 4.9 standard deviations above the background-only hypothesis. Four top quark production is observed with a significance of 5.6 standard deviations, and its cross section is measured to be 17.7−3.5+3.7(stat)−1.9+2.3(syst)fb, in agreement with the available standard model predictions.
Published: 2023
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42. Specificity and efficiency of tamoxifen-mediated Cre induction is equivalent regardless of age

Author: Collyn M. Kellogg, Kevin Pham, Sunghwan Ko, Jillian E.J. Cox, Adeline H. Machalinski, Michael B. Stout, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, and Willard M. Freeman
Subjects: Natural sciences, Biological sciences, Genomics, Biological sciences research methodologies, Biology experimental methods, Science
Abstract: Summary: Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (12 m.o.). While anecdotally reported as problematic, there are no published comparisons of Tam-mediated Cre induction at early and late ages. Here, microglial-specific Cx3cr1creERT2 mice were crossed to a floxed NuTRAP reporter to compare Cre induction at early (3–6 m.o.) and late (20 m.o.) ages. Specificity and efficiency of microglial labeling at 21–22 m.o. were identical in mice induced with Tam at early and late ages. Age-related microglial translatomic changes were also similar regardless of Tam induction age. Each Cre and flox mouse line should be independently validated, however, these findings demonstrate that Tam-mediated Cre induction can be performed even into older mouse ages and should be generalizable to other inducible Cre models.
Published: 2023
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43. Search for heavy long-lived multi-charged particles in the full LHC Run 2 pp collision data at s=13 TeV using the ATLAS detector

Author: G. Aad, B. Abbott, D.C. Abbott, K. Abeling, S.H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, A.C. Abusleme Hoffman, B.S. Acharya, B. Achkar, C. Adam Bourdarios, L. Adamczyk, L. Adamek, S.V. Addepalli, J. Adelman, A. Adiguzel, S. Adorni, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, J.A. Aguilar-Saavedra, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, I. Aizenberg, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, M.J. Alconada Verzini, S. Alderweireldt, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, A. Alfonsi, F. Alfonsi, M. Alhroob, B. Ali, S. Ali, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, E. Alunno Camelia, M. Alvarez Estevez, M.G. Alviggi, Y. Amaral Coutinho, A. Ambler, C. Amelung, C.G. Ames, D. Amidei, S.P. Amor Dos Santos, S. Amoroso, K.R. Amos, C.S. Amrouche, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, M.T. Anthony, E. Antipov, M. Antonelli, D.J.A. Antrim, F. Anulli, M. Aoki, T. Aoki, J.A. Aparisi Pozo, M.A. Aparo, L. Aperio Bella, C. Appelt, N. Aranzabal, V. Araujo Ferraz, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, A.J. Armbruster, O. Arnaez, H. Arnold, Z.P. Arrubarrena Tame, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, J. Assahsah, K. Assamagan, R. Astalos, R.J. Atkin, M. Atkinson, N.B. Atlay, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avner, G. Avolio, K. Axiotis, M.K. Ayoub, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, P. Bagnaia, M. Bahmani, A.J. Bailey, V.R. Bailey, J.T. Baines, C. Bakalis, O.K. Baker, P.J. Bakker, E. Bakos, D. Bakshi Gupta, S. Balaji, R. Balasubramanian, E.M. Baldin, P. Balek, E. Ballabene, F. 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Tang, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G.F. Tartarelli, P. Tas, M. Tasevsky, E. Tassi, A.C. Tate, G. Tateno, Y. Tayalati, G.N. Taylor, W. Taylor, H. Teagle, A.S. Tee, R. Teixeira De Lima, P. Teixeira-Dias, J.J. Teoh, K. Terashi, J. Terron, S. Terzo, M. Testa, R.J. Teuscher, A. Thaler, O. Theiner, N. Themistokleous, T. Theveneaux-Pelzer, O. Thielmann, D.W. Thomas, J.P. Thomas, E.A. Thompson, P.D. Thompson, E. Thomson, E.J. Thorpe, Y. Tian, V. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, E.X.L. Ting, P. Tipton, S. Tisserant, S.H. Tlou, A. Tnourji, K. Todome, S. Todorova-Nova, S. Todt, M. Togawa, J. Tojo, S. Tokár, K. Tokushuku, R. Tombs, M. Tomoto, L. Tompkins, K.W. Topolnicki, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, M. Toscani, C. Tosciri, D.R. Tovey, A. Traeet, I.S. Trandafir, T. Trefzger, A. Tricoli, I.M. Trigger, S. Trincaz-Duvoid, D.A. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, M. Tsai, A. Tsiamis, P.V. Tsiareshka, S. Tsigaridas, A. Tsirigotis, V. Tsiskaridze, E.G. Tskhadadze, M. Tsopoulou, Y. Tsujikawa, I.I. Tsukerman, V. Tsulaia, S. Tsuno, O. Tsur, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A.N. Tuna, S. Turchikhin, I. Turk Cakir, R. Turra, T. Turtuvshin, P.M. Tuts, S. Tzamarias, P. Tzanis, E. Tzovara, K. Uchida, F. Ukegawa, P.A. Ulloa Poblete, G. Unal, M. Unal, A. Undrus, G. Unel, J. Urban, P. Urquijo, G. Usai, R. Ushioda, M. Usman, Z. Uysal, V. Vacek, B. Vachon, K.O.H. Vadla, T. Vafeiadis, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, A. Vallier, J.A. Valls Ferrer, T.R. Van Daalen, P. Van Gemmeren, M. Van Rijnbach, S. Van Stroud, I. Van Vulpen, M. Vanadia, W. Vandelli, M. Vandenbroucke, E.R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E.W. Varnes, C. Varni, T. Varol, D. Varouchas, L. Varriale, K.E. Varvell, M.E. Vasile, L. Vaslin, G.A. Vasquez, F. Vazeille, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M.J. Veen, I. Veliscek, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, J.C. Vermeulen, C. Vernieri, P.J. Verschuuren, M. Vessella, M.C. Vetterli, A. Vgenopoulos, N. Viaux Maira, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E.M. Villhauer, E. Vilucchi, M.G. Vincter, G.S. Virdee, A. Vishwakarma, C. Vittori, I. Vivarelli, V. Vladimirov, E. Voevodina, F. Vogel, P. Vokac, J. Von Ahnen, E. Von Toerne, B. Vormwald, V. Vorobel, K. Vorobev, M. Vos, J.H. Vossebeld, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, M. Vreeswijk, R. Vuillermet, O. Vujinovic, I. Vukotic, S. Wada, C. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, R. Wakasa, M. Wakida, V.M. Walbrecht, J. Walder, R. Walker, W. Walkowiak, A.M. Wang, A.Z. Wang, C. Wang, H. Wang, J. Wang, P. Wang, R.-J. Wang, R. Wang, S.M. Wang, S. Wang, T. Wang, W.T. Wang, W.X. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, R.J. Ward, N. Warrack, A.T. Watson, M.F. Watson, G. Watts, B.M. Waugh, A.F. Webb, C. Weber, M.S. Weber, S.M. Weber, C. Wei, Y. Wei, A.R. Weidberg, J. Weingarten, M. Weirich, C. Weiser, C.J. Wells, T. Wenaus, B. Wendland, T. Wengler, N.S. Wenke, N. Wermes, M. Wessels, K. Whalen, A.M. Wharton, A.S. White, A. White, M.J. White, D. Whiteson, L. Wickremasinghe, W. Wiedenmann, C. Wiel, M. Wielers, N. Wieseotte, C. Wiglesworth, L.A.M. Wiik-Fuchs, D.J. Wilbern, H.G. Wilkens, D.M. Williams, H.H. Williams, S. Williams, S. Willocq, P.J. Windischhofer, F. Winklmeier, B.T. Winter, M. Wittgen, M. Wobisch, R. Wölker, J. Wollrath, M.W. Wolter, H. Wolters, V.W.S. Wong, A.F. Wongel, S.D. Worm, B.K. Wosiek, K.W. Woźniak, K. Wraight, J. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, X. Xiao, M. Xie, X. Xie, J. Xiong, I. Xiotidis, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, W. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, N. Yamaguchi, Y. Yamaguchi, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, Y.C. Yap, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, M.R. Yexley, P. Yin, K. Yorita, C.J.S. Young, C. Young, M. Yuan, R. Yuan, L. Yue, X. Yue, M. Zaazoua, B. Zabinski, E. Zaid, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, S.V. Zeißner, C. Zeitnitz, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, B. Zhang, D.F. Zhang, G. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Z. Zhang, H. Zhao, P. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, C. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, C. Zhu, H.L. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search for heavy long-lived multi-charged particles is performed using the ATLAS detector at the LHC. Data collected in 2015–2018 at s=13 TeV from pp collisions corresponding to an integrated luminosity of 139 fb−1 are examined. Particles producing anomalously high ionization, consistent with long-lived spin-½ massive particles with electric charges from |q|=2e to |q|=7e are searched for. No statistically significant evidence of such particles is observed, and 95% confidence level cross-section upper limits are calculated and interpreted as the lower mass limits for a Drell–Yan plus photon-fusion production mode. The least stringent limit, 1060 GeV, is obtained for |q|=2e particles, and the most stringent one, 1600 GeV, is for |q|=6e particles.
Published: 2023
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44. Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease

Author: Fabliha A. Chowdhury, Nicole Colussi, Malini Sharma, Katherine C. Wood, Julia Z. Xu, Bruce A. Freeman, Francisco J. Schopfer, and Adam C. Straub
Subjects: Nitro-fatty acid, Sickle cell anemia, Oxidative stress, Inflammation, Multi-organ pathophysiology, Vascular, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of disease-associated complications including anemia, oxidative stress, sterile inflammation, vaso-occlusive crisis-related pain, and vasculopathy, all of which contribute to multiorgan dysfunction and failure. Over the past decade, numerous small molecule drugs, biologics, and gene-based interventions have been evaluated; however, only four disease-modifying drug therapies are presently FDA approved. Barriers regarding effectiveness, accessibility, affordability, tolerance, and compliance of the current polypharmacy-based disease-management approaches are challenging. As such, there is an unmet pharmacological need for safer, more efficacious, and logistically accessible treatment options for SCD patients. Herein, we evaluate the potential of small molecule nitroalkenes such as nitro-fatty acid (NO2-FA) as a therapy for SCD. These agents are electrophilic and exert anti-inflammatory and tissue repair effects through an ability to transiently post-translationally bind to and modify transcription factors, pro-inflammatory enzymes and cell signaling mediators. Preclinical and clinical studies affirm safety of the drug class and a murine model of SCD reveals protection against inflammation, fibrosis, and vascular dysfunction. Despite protective cardiac, renal, pulmonary, and central nervous system effects of nitroalkenes, they have not previously been considered as therapy for SCD. We highlight the pathways targeted by this drug class, which can potentially prevent the end-organ damage associated with SCD and contrast their prospective therapeutic benefits for SCD as opposed to current polypharmacy approaches.
Published: 2023
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45. Protocol for establishing a protein interactome based on close physical proximity to a target protein within live budding yeast

Author: Janhavi A. Kolhe, Neethu L. Babu, and Brian C. Freeman
Subjects: Model Organisms, Molecular Biology, Protein Biochemistry, Science (General), Q1-390
Abstract: Summary: Here, we present a protocol for establishing a protein interactome based on close physical proximity to a target protein within live yeast cells. We describe steps for capturing both transient and stable binders by integrating a non-natural amino acid. We detail procedures for employing a site-directed method for labeling the surface that mediates protein associations and uncovers the binding sites on the interactors. Combined with mass spectrometry, our approach proves valuable in discovering binding partners and constructing a comprehensive protein-interaction network. : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Published: 2023
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46. Approach to amiodarone induced thyroid storm: A case report

Author: Taylor Freeman, Jillian Pattison, Salvatore Savona, Ralph Augostini, and Kyle Vankoevering
Subjects: Amiodarone, Thyroid storm, Thyrotoxicosis, Intensive care, Thyroidectomy, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Thyroid storm is a thyroid emergency with increased risk for mortality due to elevated levels of circulating thyroid hormone. While it can be caused by a variety of etiologies, thyroid storm secondary to amiodarone can be particularly challenging to manage. This paper describes a case of a 65-year-old man who presented from outside hospital with persistent ventricular tachycardia and multiple implantable defibrillator firings from thyroid storm following amiodarone infusion. Despite conventional first-line pharmacotherapy, he developed cardiogenic shock and multi-organ failure requiring therapeutic plasma exchange. Due to continued deterioration, he underwent emergent total thyroidectomy. Following surgery, the patient experienced clinical stabilization and has now made a complete recovery. In this paper, we highlight the complexities in the management of amiodarone induced thyrotoxicosis and offer a treatment algorithm and indications for early, definitive management with thyroidectomy.
Published: 2023
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47. Infected aortic endograft with an unusual microbe, Burkholderia cepacia

Author: Evan E. Foulke, MD, Benjamin C. Powell, MD, Brett Salomon, MD, Joshua Arnold, MD, FACS, and Michael B. Freeman, MD, FACS
Subjects: Burkholderia cepacia, Endograft infection, Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: With the growing use of endovascular aortic repair for aortic aneurysm pathology, multiple cases have been reported of associated endovascular graft infections. Explantation of the infected endograft and the revascularization procedure performed should be individualized with attention to the offending organism. We present the cases of two patients who underwent endovascular aortic repair with the same endograft and developed a graft infection with Burkholderia cepacia, a gram-negative organism with low virulence. Both endografts cultured Burkholderia cepacia complex; however, the organisms were genetically tested and found to be separate, unrelated strains. Both patients underwent successful explantation and revascularization procedures without any surgical-related complications to date.
Published: 2023
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48. Cold atmospheric pressure plasma-antibiotic synergy in Pseudomonas aeruginosa biofilms is mediated via oxidative stress response

Author: Jordanne-Amee Maybin, Thomas P. Thompson, Padrig B. Flynn, Timofey Skvortsov, Noreen J. Hickok, Theresa A. Freeman, and Brendan F. Gilmore
Subjects: Pseudomonas aeruginosa, Biofilm, Plasma Medicine, Cold plasma, Antimicrobial synergy, Transcriptomics, Biotechnology, TP248.13-248.65, Microbiology, QR1-502
Abstract: Cold atmospheric-pressure plasma (CAP) has emerged as a potential alternative or adjuvant to conventional antibiotics for the treatment of bacterial infections, including those caused by antibiotic-resistant pathogens. The potential of sub-lethal CAP exposures to synergise conventional antimicrobials for the eradication of Pseudomonas aeruginosa biofilms is investigated in this study. The efficacy of antimicrobials following or in the absence of sub-lethal CAP pre-treatment in P. aeruginosa biofilms was assessed. CAP pre-treatment resulted in an increase in both planktonic and biofilm antimicrobial sensitivity for all three strains tested (PAO1, PA14, and PA10548), with both minimum inhibitory concentrations (MICs) and minimum biofilm eradication concentrations (MBECs) of individual antimicrobials, being significantly reduced following CAP pre-treatment of the biofilm (512-fold reduction with ciprofloxacin/gentamicin; and a 256-fold reduction with tobramycin). At all concentrations of antimicrobial used, the combination of sub-lethal CAP exposure and antimicrobials was effective at increasing time-to-peak metabolism, as measured by isothermal microcalorimetry, again indicating enhanced susceptibility. CAP is known to damage bacterial cell membranes and DNA by causing oxidative stress through the in situ generation of reactive oxygen and nitrogen species (RONS). While the exact mechanism is not clear, oxidative stress on outer membrane proteins is thought to damage/perturb cell membranes, confirmed by ATP and LDH leakage, allowing antimicrobials to penetrate the bacterial cell more effectively, thus increasing bacterial susceptibility. Transcriptomic analysis, reveals that cold-plasma mediated oxidative stress caused upregulation of P. aeruginosa superoxide dismutase, cbb3 oxidases, catalases, and peroxidases, and upregulation in denitrification genes, suggesting that P. aeruginosa uses these enzymes to degrade RONS and mitigate the effects of cold plasma mediated oxidative stress. CAP treatment also led to an increased production of the signalling molecule ppGpp in P. aeruginosa, indicative of a stringent response being established. Although we did not directly measure persister cell formation, this stringent response may potentially be associated with the formation of persister cells in biofilm cultures. The production of ppGpp and polyphosphate may be associated with protein synthesis inhibition and increase efflux pump activity, factors which can result in antimicrobial tolerance. The transcriptomic analysis also showed that by 6 h post-treatment, there was downregulation in ribosome modulation factor, which is involved in the formation of persister cells, suggesting that the cells had begun to resuscitate/recover. In addition, CAP treatment at 4 h post-exposure caused downregulation of the virulence factors pyoverdine and pyocyanin; by 6 h post-exposure, virulence factor production was increasing. Transcriptomic analysis provides valuable insights into the mechanisms by which P. aeruginosa biofilms exhibits enhanced susceptibility to antimicrobials. Overall, these findings suggest, for the first time, that short CAP sub-lethal pre-treatment can be an effective strategy for enhancing the susceptibility of P. aeruginosa biofilms to antimicrobials and provides important mechanistic insights into cold plasma-antimicrobial synergy. Transcriptomic analysis of the response to, and recovery from, sub-lethal cold plasma exposures in P. aeruginosa biofilms improves our current understanding of cold plasma biofilm interactions.
Published: 2023
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49. The concept of land bridge marshes in the Mississippi River Delta and implications for coastal restoration

Author: John W. Day, Robert R. Twilley, Angelina Freeman, Brady Couvillion, Tracy Quirk, Navid Jafari, Giulio Mariotti, Rachael Hunter, Charles Norman, G. Paul Kemp, John R. White, and Ehab Meselhe
Subjects: Environmental sciences, GE1-350
Abstract: Louisiana has high coastal wetland loss rates due to natural processes such as subsidence and anthropogenic activities such as construction of river levees and dams, pervasive alteration of surface hydrology by local industries such as oil and gas, and navigation. With the exception of the Atchafalaya River discharge area, most of Louisiana's marsh coastline is retreating and coastal marshes are degrading. In the inactive degrading delta regions, there exists a previously uncharacterized landform referred to colloquially as coastal ‘land bridge’ marshes. Land bridge marshes are saline or brackish marshes fronting large estuarine bays or lakes with sufficient fetch and wave energy to supply high levels of resuspended sediments to the marsh surface. They are generally linear features that are oriented parallel to the coast and the shoreline front retreats landward due to erosion from wave energy. These marshes persist over time vertically due to input of resuspended sediments but are experiencing rapid edge erosion due to wave attack. Comparison of data from Louisiana's Coastal Reference Monitoring System (CRMS) sites show that land bridge marshes have a greater frequency of higher soil surface elevation and higher soil bulk density than non-land bridge marshes. Because land bridges are vertically stable relative to other coastal wetlands, identification of measures to sustain these landscape features is important. Simulations using MarshMorpho2D, a process-based reduced-complexity morphology model, suggest that protection barriers installed on the seaward side of land bridge marshes will attenuate wave energy and, thus, edge erosion. Shoreline protection that can reduce wave energy but still allow sediment input to marshes include living shorelines, rock barriers, and/or breakwaters. Periodic thin layer nourishment of the marsh surface may be necessary to help sustain vertical growth. Further, marsh creation projects directly landward of land bridge marshes may benefit from their protection from waves and as a source of sediment. Consideration of land bridge marshes as distinct marsh types in the State Master Plan and integrated modeling could help to identify measures to sustain these landscape features.
Published: 2023
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50. WITHDRAWN: Knowledge and attitudes towards utilizing complementary and alternative medical (CAM) treatments by mental health practitioner from various disciplines

Author: Sharon Freeman Clevenger
Subjects: Medicine
Abstract: This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Published: 2023
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