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1. Functional structure of the natural enemy community of the fall armyworm, Spodoptera frugiperda in the Americas

Author: Kris A.G. Wyckhuys, Komivi S. Akutse, Divina M. Amalin, Salah-Eddin Araj, Gloria Barrera, Marie Joy B. Beltran, Ibtissem Ben Fekih, Paul-André Calatayud, Lizette Cicero, Marcellin C. Cokola, Yelitza C. Colmenarez, Kenza Dessauvages, Thomas Dubois, Léna Durocher-Granger, Carlos Espinel, José L. Fernández-Triana, Frederic Francis, Juliana Gómez, Khalid Haddi, Rhett D. Harrison, Muhammad Haseeb, Natasha S.A. Iwanicki, Lara R. Jaber, Fathiya M. Khamis, Jesusa C. Legaspi, Refugio J. Lomeli-Flores, Rogerio B. Lopes, Baoqian Lyu, James Montoya-Lerma, Tung D. Nguyen, Ihsan Nurkomar, Jermaine D. Perier, Gabor Pozsgai, Ricardo Ramírez-Romero, Annmarie S. Robinson-Baker, Francisco J. Sanchez-Garcia, Luis C. Silveira, Larisner Simeon, Leellen F. Solter, Oscar F. Santos-Amaya, Wagner de Souza Tavares, Rogelio Trabanino, Carlos Vásquez, Zhenying Wang, Ana P.G.S. Wengrat, Lian-Sheng Zang, Wei Zhang, Kennedy J. Zimba, Kongming Wu, and Maged Elkahky
Subjects: Biodiversity conservation, Agroecology, Ecological intensification, Functional ecology, Species richness, Biodiversity – ecosystem functioning, Agriculture, Biology (General), QH301-705.5
Abstract: Ecosystem functions such as biological pest control are mediated by the richness and abundance of service providers i.e., biological control agents (BCAs), relative contributions of individual taxa and community structure. This is especially relevant in the native range of agricultural herbivores, where a speciose community of co-evolved BCAs can prevent them from attaining pest status. Here, we use a powerful graphical approach to assess the functional structure of BCA communities of the fall armyworm (FAW) Spodoptera frugiperda (Lepidoptera: Noctuidae) on maize in the Neotropics. Drawing upon a curated database of all-time field and laboratory studies, we graphed patterns in the functional contribution, abundance and niche breadth for a respective 69, 53 and 3 taxa of resident parasitoids, predators and pathogens. Regardless of varying taxon coverage and rigor of the underlying studies, functional structure follows a saturating relationship in which the first three taxa account for 90–98% of aggregate biological control function. Abundance-functionality matrices prove critically incomplete, as more than 80% of invertebrate taxa miss empirically derived efficiency metrics while associated FAW infestation data are scarce. Despite its methodological shortfalls and data gaps, our work pinpoints Chelonus insularis, several taxa of egg parasitoids, Doru spp. and Orius spp. as taxa with outsized (average) functionality and conservation potential. This is also exemplified by the highly variable aggregate function across studies, with dispersion indices of 1.52 and 2.14 for invertebrate BCAs. Our work underlines the critical importance of functional ecology research, networked trials and standardized methodologies in advancing conservation biological control globally.
Published: 2024
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2. Global scientific progress and shortfalls in biological control of the fall armyworm Spodoptera frugiperda

Author: Kris A.G. Wyckhuys, Komivi S. Akutse, Divina M. Amalin, Salah-Eddin Araj, Gloria Barrera, Marie Joy B. Beltran, Ibtissem Ben Fekih, Paul-André Calatayud, Lizette Cicero, Marcellin C. Cokola, Yelitza C. Colmenarez, Kenza Dessauvages, Thomas Dubois, Léna Durocher-Granger, Carlos Espinel, Patrick Fallet, José L. Fernández-Triana, Frederic Francis, Juliana Gómez, Khalid Haddi, Rhett D. Harrison, Muhammad Haseeb, Natasha S.A. Iwanicki, Lara R. Jaber, Fathiya M. Khamis, Jesusa C. Legaspi, Refugio J. Lomeli-Flores, Rogerio B. Lopes, Baoqian Lyu, James Montoya-Lerma, Melissa P. Montecalvo, Andrew Polaszek, Tung D. Nguyen, Ihsan Nurkomar, James E. O'Hara, Jermaine D. Perier, Ricardo Ramírez-Romero, Francisco J. Sánchez-García, Ann M. Robinson-Baker, Luis C. Silveira, Larisner Simeon, Leellen F. Solter, Oscar F. Santos-Amaya, Elijah J. Talamas, Wagner de Souza Tavares, Rogelio Trabanino, Ted C.J. Turlings, Fernando H. Valicente, Carlos Vásquez, Zhenying Wang, Ana P.G.S. Wengrat, Lian-Sheng Zang, Wei Zhang, Kennedy J. Zimba, Kongming Wu, Maged Elkahky, and Buyung A.R. Hadi
Subjects: Ecological intensification, Global change, Biological control, Agroecology, Ecosystem services, Agrochemical pollution, Agriculture, Biology (General), QH301-705.5
Abstract: Since 2016, the fall armyworm (FAW) Spodoptera frugiperda has spread over extensive areas of the tropics and subtropics, imperiling food security, economic progress and the livelihoods of millions of cereal farmers. Although FAW has received long-standing scientific attention in its home range in the Americas, chemical inputs feature prominently in its mitigation and biological control uptake is globally lagging. Here, building upon a quantitative review of the global literature, we methodically dissect FAW biological control science. Of the known entomopathogens (46), parasitoids (304) and predators (215) of FAW, approx. 40% have been subject to laboratory- or field-level scrutiny. Laboratory-level performance has partially been assessed for 14–18% of the above invertebrate taxa. Yet, organismal, geographic, methodological and thematic biases hamper efforts to relate in-field biodiversity to actual ecosystem service delivery. Often, single-guild ‘snapshot’ surveys are preferred over comprehensive bio-inventories or population dynamics appraisals, trophic interactions are wrongly inferred from co-occurrence, standard pest infestation metrics are lacking and natural enemy censuses are performed arbitrarily. Diurnal biota receive inordinate attention, while egg and pupal predation - the main biotic sources of mortality - are routinely overlooked. Multiple microbial and invertebrate biota are investigated with a view towards mass-rearing and augmentative release, but the basis for agent selection is often unclear. Lastly, conservation biological control receives marginal attention and cross-disciplinary engagement with the agroecology domain is lagging. We lay out several steps, including standardized methodologies, smart use of biodemographic toolkits, networked field trials and a fortification of its ecological underpinnings, to sharpen the science of (FAW) biological control and urge further momentum in its global implementation.
Published: 2024
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3. Implementation of the Capital System for a Knowledge City

Author: FLORES, P, primary
Published: 2006
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4. Acetylcholinesterase inhibition exerted by the extract of Daldinia eschscholtzii, a marine fungus associated with the coral Siderastrea siderea: GC-MS analysis and molecular docking of identified compounds

Author: Karla G. Olivo-Flores, Alan Couttolenc, Jorge Suárez-Medellín, Ángel Trigos, and César Espinoza
Subjects: 4,7-dihydroxycoumarin, Ligand-enzyme interactions, Acetylcholinesterase, AChE Inhibition, Bioprospecting, Coral-derived fungus, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5
Abstract: Background: Alzheimer’s disease is a neurodegenerative disease that has no cure. The drugs used to treat Alzheimer’s disease are based on the inhibition of the enzyme acetylcholinesterase (AChE). In this sense, marine fungal metabolites represent an alternative source for the discovery of drugs based on AChE inhibition (IAChE). The present research carried out a bioprospecting study of marine fungi with acetylcholinesterase inhibition potential. Results: A total of 17 marine fungi were isolated from three stony corals from the Veracruz Reef System. The fungal genera identified were Geotrichum, Curvularia, Penicillium, Aspergillus, and Daldinia. The IAChE was evaluated from the broth and biomass extracts of each fungal strain. As a result, Daldinia eschscholtzii was one of the three fungi with the greatest IAChE effect (32.7%). Subsequently, a bio-directed chromatographic purification of the methanolic extract of the biomass of D. eschscholtzii was carried out. The FRL8.1 fraction was the most active with an IAChE of 41.0%, a value close to Galantamine positive control (44.0%). Furthermore, compound analysis was carried out by GC-MS. Finally, it was determined that the metabolites responsible for the inhibitory effect are probably 4,7-dihydroxycoumarin and 5-nitro-2-naphthalenamine, which was demonstrated by their interactions with the AChE enzyme receptor through molecular docking studies. Conclusions: Coral-associated marine fungi produce secondary metabolites that inhibit acetylcholinesterase. This is the first report of D. eschscholtzii isolated from the stony coral Siderastrea siderea. Finally, we consider that more studies are needed to demonstrate the IAChE potential of marine fungi associated with corals or other marine organisms.How to cite: Olivo-Flores KG, Couttolenc A, Suárez-Medellín J, et al. Acetylcholinesterase inhibition exerted by the extract of Daldinia eschscholtzii, a marine fungus associated with the coral Siderastrea siderea: GC–MS analysis and molecular docking of identified compounds. Electron J Biotechnol 2024;72. https://doi.org/10.1016/j.ejbt.2024.08.001.
Published: 2024
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5. A Case Report and Literature Review of a Giant Bladder Stone in a 43-year-old Female (9 x 8 x 4 cm, 250g)

Author: Carlos David Franco-González, Jorge A. Martin-Millet, Carolina A. González-Guillermo, Mariana Méndez-Atoche, Paulina Caballero-Osorno, and Juan P. Flores-Tapia
Subjects: Urology, Urolithiasis, Bladder calculi, Cystolith, Giant bladder stone, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract: Cystoliths are an uncommon manifestation of urolithiasis. They are typically observed in male patients who are over the age of 45. A giant bladder calculus is a stone that is greater than 4 cm in diameter and weighs more than 100 g. We report the case of a 43- year-old female who was admitted to the urology department with dysuria, lower abdominal pain, fever, nausea, and microscopic hematuria. Mild tenderness in the suprapubic region was noted during the patient's physical examination. A hyperdense image measuring 7.2 x 6.4 cm was revealed during an abdominal CT scan, which confirmed the diagnosis. A 280 g stone, measuring 9 x 8 x 4 cm, was extracted through open cystolithotomy. In the female population, bladder calculus formation is uncommon. The standard treatment is open cystolithotomy, and computed tomography is a valuable tool for confirming the diagnosis.
Published: 2024
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6. Gastrointestinal adverse effects of old and new antidiabetics: How do we deal with them in real life?

Author: J.R. Barrientos-Ávalos, E.C. Morel-Cerda, F.A. Félix-Téllez, B.E. Vidrio-Huerta, A.R. Aceves-Ayala, Á.R. Flores-Rendón, and J.A. Velarde-Ruiz Velasco
Subjects: Antidiabéticos, Efectos adversos, Análogos GLP1, Síntomas gastrointestinales, Metformina, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Diabetes is a public health problem with an estimated worldwide prevalence of 10% and a prevalence of 12% in Mexico. The costs resulting from this chronic-degenerative disease are significant. Treatment for diabetes involves different medication groups, some of which can cause significant gastrointestinal adverse effects, such as dyspepsia, nausea, vomiting, bloating, diarrhea, and constipation. The medications most frequently associated with said adverse effects are metformin, acarbose, and GLP-1 agonists. Gastrointestinal adverse effects negatively impact the quality of life and management of patients with diabetes. The factors of visceral neuropathy, acute dysglycemia, dysbiosis, and intestinal bacterial overgrowth contribute to the gastrointestinal symptoms in patients with diabetes, making it necessary to consider multiple etiologic factors in the presence of gastrointestinal symptoms, and not exclusively attribute them to the use of antidiabetics. Personalized treatment, considering gastrointestinal comorbidity and the type of drug utilized, is essential for mitigating the adverse effects and improving the quality of life in patients with diabetes. The aim of the present narrative review was to describe the gastrointestinal adverse effects of the antidiabetic drugs, their pathophysiologic mechanisms, and the corresponding therapeutic measures. Resumen: La diabetes es un problema de salud pública con prevalencias globales estimadas del 10% y en México del 12%. Esta enfermedad crónico-degenerativa genera costos significativos. El tratamiento para la diabetes involucra diversos grupos de medicamentos, algunos de los cuales pueden provocar efectos adversos gastrointestinales significativos, como dispepsia, náuseas, vómitos, distensión abdominal, diarrea y estreñimiento. Los medicamentos asociados con mayor frecuencia a dichos efectos adversos son la metformina, acarbosa y agonistas GLP-1. Los efectos adversos gastrointestinales impactan en la calidad de vida y en el manejo de los pacientes con diabetes. Factores como la neuropatía visceral, disglucemia aguda, disbiosis y el sobrecrecimiento bacteriano intestinal también contribuyen a los síntomas gastrointestinales en pacientes con diabetes por lo que se deben de considerar múltiples opciones etiológicas ante síntomas gastrointestinales y no atribuirlos exclusivamente al uso de antidiabéticos. La individualización del tratamiento, considerando la comorbilidad gastrointestinal y el tipo de fármaco utilizado, es crucial para mitigar los efectos adversos y mejorar la calidad de vida de los pacientes con diabetes. Esta revisión narrativa tiene como objetivo describir los efectos adversos gastrointestinales de los antidiabéticos, así como sus mecanismos fisiopatológicos y las medidas terapéuticas correspondientes.
Published: 2024
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7. Chronic nausea and vomiting syndrome and impact on quality of life

Author: F.A. Félix-Téllez, J.A. Velarde-Ruiz Velasco, J.M. Aldana-Ledesma, E.S. García-Jiménez, E.C. Morel-Cerda, A.R. Flores-Rendón, and J.M. Remes-Troche
Subjects: Náusea, Vómito, Síndrome de náusea y vómito crónico, Trastornos de la interacción cerebro intestino, Calidad de vida, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Introduction and aim: Chronic nausea and vomiting syndrome is a disorder of gut-brain interaction that affects the productive-age population. Our aim was to determine the association of this disorder with quality of life, workplace performance, and socioeconomic impact related to gastrointestinal health. Methods: A cross-sectional study on a Mexican population was conducted. The patients were classified as having chronic nausea and vomiting syndrome or other disorders of gut-brain interaction. A comparative analysis of quality of life, workplace productivity, annual medical consultations, and digestive health-related expenses was carried out, applying a logistic regression model. Results: One thousand patients were included, 79.2% of whom met the criteria for a disorder of gut-brain interaction. Of the 792 patients, 10.3% presented with chronic nausea and vomiting syndrome. Said syndrome was associated with a negative impact on usual activities (OR 4.34, 95% CI 1.90-9.30, p ≤ 0.001), pain/discomfort (OR 2.09, 95% CI 1.31-3.33, p ≤ 0.001), anxiety/depression (OR 2.08, 95% CI 1.30-3.40, p ≤ 0.001), workplace presenteeism (OR 3.96, 95% CI 2.47-6.44, p ≤ 0.001), and workplace absenteeism (OR 2.54, 95% CI 1.52-4.16, p ≤ 0.001). There was also a higher number of annual medical consultations for digestive health (p = 0.013), without generating a greater annual expense due to digestive health (p = 0.08). Conclusions: Chronic nausea and vomiting syndrome produces a negative impact on quality of life, which could be secondary to its symptomatology or its association with anxiety and depression. Resumen: Introducción: El síndrome de náusea y vómito crónico es un trastorno de la interacción cerebro intestino que afecta a la población en edad productiva. El objetivo fue determinar la asociación de este trastorno con la calidad de vida, desempeño laboral e impacto socioeconómico relacionado a la salud gastrointestinal. Métodos: Un estudio de corte transversal en población mexicana. Los pacientes se clasificaron como síndrome de náusea y vómito crónico u otros trastornos de la interacción cerebro intestino. Se realizó un análisis comparativo de la calidad de vida, productividad laboral, consulta médica anual y gastos relacionados a salud digestiva aplicando un modelo de regresión logística. Resultados: Se incluyeron 1000 pacientes, de los cuales 79.2% cumplían criterios de algún trastorno de la interacción cerebro intestino. De los 792 pacientes, 10.3% presentaban síndrome de náusea y vómito crónico. El síndrome de náusea y vómito crónico se asoció a un impacto negativo en las actividades usuales (OR 4.34, IC95%, 1.90-9.30, p =
Published: 2024
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8. Development of probiotic yogurt products incorporated with Lactobacillus kefiranofaciens OSU-BSGOA1 in mono- and coculture with Kluyveromyces marxianus

Author: Brianda D. González-Orozco, Chloe J. McGovern, Sheryl A. Barringer, Christopher Simons, Rafael Jiménez-Flores, and Valente B. Alvarez
Subjects: kefir microorganisms, probiotic delivery, yogurt, volatile flavor profile, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract: ABSTRACT: The bacterium Lactobacillus kefiranofaciens OSU-BDGOA1 and yeast Kluyveromyces marxianus bdgo-ym6 were previously isolated from kefir grains and have shown probiotic traits in mono- and coculture. This research evaluates the effect of introducing probiotic kefir microorganisms in monoculture and in coculture alongside yogurt starter cultures on the physicochemical and rheological properties, volatile flavor compounds, survival of the microorganisms during simulated digestion, and sensory attributes of the final fermented products. The incorporation of L. kefiranofaciens OSU-BDGOA1 in monoculture showed promising outcomes, resulting in a final product showing more solid-like characteristics and potentially improving the texture of the product. There was also a significant increase in the concentration of desirable volatile flavor compounds in the yogurt with the monoculture, particularly 2,3-butanedione, displaying a positive correlation with buttery flavor in the sensory analysis. The inclusion of L. kefiranofaciens in monoculture also promoted better sensory attributes and was significantly better than the yogurt with the coculture with the yeast, showing promising results for the incorporation of this probiotic bacterium into functional fermented dairy products.
Published: 2024
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9. Radiological features of Joubert syndrome and clinical case presentation

Author: Jorge Ariel Montero Torres, MD, Bruno Flores Escobar, MD, Julian Guzman Martinez, MD, Ricardo Alfonso Barrera Martínez, MD, and Frida Priscila Hernández Cortez, MD
Subjects: Joubert syndrome, Vermis, Cerebellum, Cerebellar vermis hypoplasia, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract: Joubert Syndrome, manifests in a spectrum of neurological symptoms. This case describes a 7-year-old girl with perinatal complications, and subsequent neurodevelopmental challenges. An MRI confirmed the diagnosis of Joubert syndrome, with the distinctive “molar tooth sign” being a key imaging characteristic. Approximately 25% of cases exhibit nephronophthisis, impacting kidney function, further complicating the clinical picture. Diagnosis relies on imaging and management necessitates a multidisciplinary approach, addressing symptoms and complications, with prognosis linked to the presence of organic disease. The case emphasizes the significance of a multidisciplinary strategy, including genetic counseling, and underscores the diverse manifestations of this syndrome. Prenatal identification through ultrasound and MRI plays a crucial role in diagnosing and treating this rare condition.
Published: 2024
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10. Low-temperature sintering of ceramic bricks from clay, waste glass and sand

Author: Mario Flores Nicolás, Marcos M. Chávez, Marina Vlasova, and Teresa Pi Puig
Subjects: Arcilla, Residuos de vidrio, Arena, Propiedades mecánicas de los ladrillos cerámicos, Moldeo plástico, Clay industries. Ceramics. Glass, TP785-869
Abstract: In the present work, bricks were made on a real 1:1 scale for the construction of housing. For the preparation of the mixtures, raw materials such as clay, sand and glass obtained from the recycling of brown beer containers were used, applying the method plastic molding for the preparation of the semi-products. It has been established that the addition of sand containing a small amount of montmorillonite to such clay enabled to realization of plastic molding. The incorporation of glass into the clay provided to substantially reduce the sintering time of the bricks up to 8 h and to vary their strength properties. Sintering was carried out at 800 °C in an air atmosphere. The results of X-ray diffraction (XRD), X-ray fluorescence (XRF) and field emission scanning electron microscopy (FESEM) and EDS microanalysis have shown that the raw materials and ceramic bricks contains quartz and feldspars. Low-temperature sintering has made it possible to obtain high-quality, high-strength building bricks in accordance with standards. Resumen: En el presente trabajo, se elaboraron ladrillos a una escala real 1:1 para la construcción de viviendas. Para la preparación de las mezclas se utilizaron las materias primas como, arcilla, arena y vidrio obtenido del reciclaje de envases de cerveza color marrón aplicando el método de moldeo plástico para la preparación de los semiproductos. Se ha establecido que la adición de arena que contiene una pequeña cantidad de montmorillonita a tal arcilla permitió realizar el moldeo plástico. La incorporación de vidrio en la arcilla permitió reducir sustancialmente el tiempo de sinterización de los ladrillos hasta 8 h y variar sus propiedades de resistencia. La sinterización se ha realizado a 800 °C en una atmósfera de aire. Los resultados de los análisis de difracción de rayos X (DRX), fluorescencia de rayos X (FRX) y de microscopia electrónica de barrido de emisión de campo (FESEM), y microanálisis EDS, han demostrado que las materias primas y los ladrillos cerámicos contienen cuarzo y feldespatos. La sinterización a baja temperatura ha hecho posible obtener ladrillos de construcción de alta calidad y resistencia de acuerdo con las normas.
Published: 2024
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11. Tratamiento de fracturas supracondíleas de fémur mediante técnicas mínimamente invasivas vs. exposición del foco de fractura: un estudio de cohortes retrospectivas

Author: A. Flores Meca and Á. Ortiz Gallego
Subjects: Distal femur fracture, Epidemiology, MIS, ORIF, Complications, Orthopedic surgery, RD701-811
Abstract: Resumen: Introducción: Las fracturas de tercio distal femoral son una causa importante de morbimortalidad, siendo su tratamiento actualmente controvertido. Objetivos: Comparar los resultados entre técnicas mínimamente invasivas frente a exposición del foco de fractura. Secundariamente, evaluar la relación entre factores demográficos, mecanismo lesional y demora quirúrgica con el pronóstico de los pacientes. Método: Estudio tipo cohortes retrospectivas realizado entre 2015 y 2021 en un hospital de tercer nivel. La recogida de datos se realizó mediante la revisión de historias clínicas, midiendo parámetros demográficos, hospitalarios y estrategia de tratamiento definitivo. Se completó un año de seguimiento en todos los pacientes, evaluando la aparición de complicaciones quirúrgicas y mortalidad. Se realizó un análisis estratificado de las variables de interés entre pacientes mayores de 65 años. Resultados: Se registraron 128 fracturas, realizándose osteosíntesis definitiva en 117. Los pacientes intervenidos mediante técnicas mínimamente invasivas requirieron una menor estancia hospitalaria (9 [7-12] vs. 12 [8,75-16] días) (p = 0,007), sin diferencias en mortalidad o complicaciones durante el seguimiento. En mayores de 65 años, la apertura del foco de fractura asoció un aumento del riesgo de infección frente a las técnicas mínimamente invasivas (33,3% vs. 2%) (p = 0,507). Todos los fallecidos fueron pacientes mayores de 65 años (33,7% al año). La demora quirúrgica superior a 48 horas aumentó la mortalidad un 10% entre los mayores de 65 años (p = 0,3). Los traumatismos de alta energía presentaron mayor proporción de pseudoartrosis (27,6% vs. 6,1%) (p = 0,011). Conclusiones: Las técnicas mínimamente invasivas disminuyeron la estancia hospitalaria pero no las complicaciones ni la mortalidad a largo plazo.Nivel de evidencia: IIb. Abstract: Introduction: Fractures of the distal femoral third are an important cause of morbidity and mortality, and their treatment is currently controversial. Objectives: To compare the results between minimally invasive techniques versus exposure of the fracture site. Secondly, to evaluate the relationship between demographic factors, mechanism of injury and surgical delay with patient prognosis. Method: Retrospective cohort study carried out between 2015 and 2021 in a tertiary hospital. Data collection was performed by reviewing medical histories, measuring demographic and hospital parameters and definitive treatment strategy. One year of follow-up was completed in all patients, assessing the occurrence of surgical complications and mortality. A stratified analysis of the variables of interest was performed among patients over 65 years of age. Results: 128 fractures were recorded, with definitive osteosynthesis being performed in 117. Patients who underwent minimally invasive techniques required a shorter hospital stay (9 [7-12] vs. 12 [8.75-16] days) (p = 0.007), with no differences in mortality or complications during follow-up. In those over 65 years of age, opening the fracture site was associated with an increased risk of infection compared to minimally invasive techniques (33.3% vs. 2%) (p = 0.507). All the deceased were patients over 65 years of age (33.7% at one year). Surgical delay longer than 48 hours increased mortality by 10% among those older than 65 years (p = 0.3). High-energy trauma had a higher proportion of pseudarthrosis (27.6% vs. 6.1%) (p = 0.011). Conclusions: Minimally invasive techniques decreased hospital stay but not complications or long-term mortality.Level of evidence: IIb.
Published: 2024
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12. Electrographic seizures during low-current thalamic deep brain stimulation in mice

Author: Francisco J. Flores, Isabella Dalla Betta, John Tauber, David R. Schreier, Emily P. Stephen, Matthew A. Wilson, and Emery N. Brown
Subjects: Seizure, Deep-brain stimulation, Thalamus, Electroencephalography, Electric stimulation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Background:: Deep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT). Objectives:: To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice. Methods:: Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration. Results:: In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 μA. Conclusion:: Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.
Published: 2024
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13. A step forward in the diagnosis of urinary tract infections: from machine learning to clinical practice

Author: Emilio Flores, Laura Martínez-Racaj, Álvaro Blasco, Elena Diaz, Patricia Esteban, Maite López-Garrigós, and María Salinas
Subjects: Urinary Tract Infection, Emergency department, Urinalysis, Laboratory Medicine, Clinical Decision Support Systems, Machine learning, Biotechnology, TP248.13-248.65
Abstract: Objectives: Urinary tract infections (UTIs) are common infections within the Emergency Department (ED), causing increased laboratory workloads and unnecessary antibiotics prescriptions. The aim of this study was to improve UTI diagnostics in clinical practice by application of machine learning (ML) models for real-time UTI prediction. Methods: In a retrospective study, patient information and outcomes from Emergency Department patients, with positive and negative culture results, were used to design models – ‘Random Forest’ and ‘Neural Network’ – for the prediction of UTIs. The performance of these predictive models was validated in a cross-sectional study. In a quasi-experimental study, the impact of UTI risk assessment was investigated by evaluating changes in the behaviour of clinicians, measuring changes in antibiotic prescriptions and urine culture requests. Results: First, we trained and tested two different predictive models with 8692 cases. Second, we investigated the performance of the predictive models in clinical practice with 962 cases (Area under the curve was between 0.81 to 0.88). The best performance was the combination of both models. Finally, the assessment of the risk for UTIs was implemented into clinical practice and allowed for the reduction of unnecessary urine cultures and antibiotic prescriptions for patients with a low risk of UTI, as well as targeted diagnostics and treatment for patients with a high risk of UTI. Conclusion: The combination of modern urinalysis diagnostic technologies with digital health solutions can help to further improve UTI diagnostics with positive impact on laboratory workloads and antimicrobial stewardship.
Published: 2024
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14. Search for pair production of boosted Higgs bosons via vector-boson fusion in the bb¯bb¯ final state using pp collisions at s=13TeV with the ATLAS detector

Author: G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N.J. Abicht, S.H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B.S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, S. Aktas, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, Z.L. Alegria, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z.M.K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, K.J. Amirie, S.P. Amor Dos Santos, K.R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, A.C. Anderson, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S.J. Arbiol Val, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, R.A. Ashby Pickering, K. Assamagan, R. Astalos, K.S.V. Astrand, S. Atashi, R.J. Atkin, M. Atkinson, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T.M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J.T. Baines, L. Baines, O.K. Baker, E. Bakos, D. Bakshi Gupta, L.E. Balabram Filho, V. Balakrishnan, R. Balasubramanian, E.M. Baldin, P. Balek, E. Ballabene, F. Balli, L.M. Baltes, W.K. Balunas, J. Balz, I. Bamwidhi, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E.L. Barberio, D. Barberis, M. Barbero, M.Z. Barel, K.N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D.A. Baron Moreno, A. Baroncelli, G. Barone, A.J. Barr, J.D. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M.G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A.E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M.J. Basso, S. Bataju, R. Bate, R.L. Bates, S. Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L.T. Bazzano Hurrell, J.B. Beacham, T. Beau, J.Y. Beaucamp, P.H. Beauchemin, P. Bechtle, H.P. Beck, K. Becker, A.J. Beddall, V.A. Bednyakov, C.P. Bee, L.J. Beemster, T.A. Beermann, M. Begalli, M. Begel, A. Behera, J.K. Behr, J.F. Beirer, F. Beisiegel, M. Belfkir, G. 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Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, M. Chen, S. Chen, S.J. Chen, X. Chen, Y. Chen, C.L. Cheng, H.C. Cheng, S. Cheong, A. Cheplakov, E. Cheremushkina, E. Cherepanova, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, N. Chiedde, G. Chiodini, A.S. Chisholm, A. Chitan, M. Chitishvili, M.V. Chizhov, K. Choi, Y. Chou, E.Y.S. Chow, K.L. Chu, M.C. Chu, X. Chu, Z. Chubinidze, J. Chudoba, J.J. Chwastowski, D. Cieri, K.M. Ciesla, V. Cindro, A. Ciocio, F. Cirotto, Z.H. Citron, M. Citterio, D.A. Ciubotaru, A. Clark, P.J. Clark, N. Clarke Hall, C. Clarry, J.M. Clavijo Columbie, S.E. Clawson, C. Clement, J. Clercx, Y. Coadou, M. Cobal, A. Coccaro, R.F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, B. Cole, J. Collot, P. Conde Muiño, M.P. Connell, S.H. Connell, E.I. Conroy, F. Conventi, H.G. Cooke, A.M. Cooper-Sarkar, F.A. Corchia, A. Cordeiro Oudot Choi, L.D. Corpe, M. Corradi, F. Corriveau, A. Cortes-Gonzalez, M.J. Costa, F. Costanza, D. 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Simion, R. Simoniello, E.L. Simpson, H. Simpson, L.R. Simpson, N.D. Simpson, S. Simsek, S. Sindhu, P. Sinervo, S. Singh, S. Sinha, M. Sioli, I. Siral, E. Sitnikova, J. Sjölin, A. Skaf, E. Skorda, P. Skubic, M. Slawinska, V. Smakhtin, B.H. Smart, S.Yu. Smirnov, Y. Smirnov, L.N. Smirnova, O. Smirnova, A.C. Smith, D.R. Smith, E.A. Smith, H.A. Smith, J.L. Smith, R. Smith, M. Smizanska, K. Smolek, A.A. Snesarev, S.R. Snider, H.L. Snoek, S. Snyder, R. Sobie, A. Soffer, C.A. Solans Sanchez, E.Yu. Soldatov, U. Soldevila, A.A. Solodkov, S. Solomon, A. Soloshenko, K. Solovieva, O.V. Solovyanov, P. Sommer, A. Sonay, W.Y. Song, A. Sopczak, A.L. Sopio, F. Sopkova, J.D. Sorenson, I.R. Sotarriva Alvarez, V. Sothilingam, O.J. Soto Sandoval, S. Sottocornola, R. Soualah, Z. Soumaimi, D. South, N. Soybelman, S. Spagnolo, M. Spalla, D. Sperlich, G. Spigo, S. Spinali, B. Spisso, D.P. Spiteri, M. Spousta, E.J. Staats, R. Stamen, A. Stampekis, M. Standke, E. Stanecka, W. Stanek-Maslouska, M.V. Stange, B. Stanislaus, M.M. Stanitzki, B. Stapf, E.A. Starchenko, G.H. Stark, J. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, G. Stavropoulos, J. Steentoft, A. Stefl, P. Steinberg, B. Stelzer, H.J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T.J. Stevenson, G.A. Stewart, J.R. Stewart, M.C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Stratmann, M. Strauss, T. Strebler, P. Strizenec, R. Ströhmer, D.M. Strom, R. Stroynowski, A. Strubig, S.A. Stucci, B. Stugu, J. Stupak, N.A. Styles, D. Su, S. Su, W. Su, X. Su, D. Suchy, K. Sugizaki, V.V. Sulin, M.J. Sullivan, D.M.S. Sultan, L. Sultanaliyeva, S. Sultansoy, T. Sumida, S. Sun, O. Sunneborn Gudnadottir, N. Sur, M.R. Sutton, H. Suzuki, M. Svatos, M. Swiatlowski, T. Swirski, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, J.S. Tafoya Vargas, Y. Takubo, M. Talby, A.A. Talyshev, K.C. Tam, N.M. Tamir, A. Tanaka, J. Tanaka, R. Tanaka, M. Tanasini, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G.F. Tartarelli, M.J. Tartarin, P. Tas, M. Tasevsky, E. Tassi, A.C. Tate, G. Tateno, Y. Tayalati, G.N. Taylor, W. Taylor, R. Teixeira De Lima, P. Teixeira-Dias, J.J. Teoh, K. Terashi, J. Terron, S. Terzo, M. Testa, R.J. Teuscher, A. Thaler, O. Theiner, N. Themistokleous, T. Theveneaux-Pelzer, O. Thielmann, D.W. Thomas, J.P. Thomas, E.A. Thompson, P.D. Thompson, E. Thomson, R.E. Thornberry, C. Tian, Y. Tian, V. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, D. Timoshyn, E.X.L. Ting, P. Tipton, A. Tishelman-Charny, S.H. Tlou, K. Todome, S. Todorova-Nova, S. Todt, L. Toffolin, M. Togawa, J. Tojo, S. Tokár, K. Tokushuku, O. Toldaiev, R. Tombs, M. Tomoto, L. Tompkins, K.W. Topolnicki, E. Torrence, H. Torres, E. Torró Pastor, M. Toscani, C. Tosciri, M. Tost, D.R. Tovey, I.S. Trandafir, T. Trefzger, A. Tricoli, I.M. Trigger, S. Trincaz-Duvoid, D.A. Trischuk, B. Trocmé, A. Tropina, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, M. Tsai, A. Tsiamis, P.V. Tsiareshka, S. Tsigaridas, A. Tsirigotis, V. Tsiskaridze, E.G. Tskhadadze, M. Tsopoulou, Y. Tsujikawa, I.I. Tsukerman, V. Tsulaia, S. Tsuno, K. Tsuri, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A.N. Tuna, S. Turchikhin, I. Turk Cakir, R. Turra, T. Turtuvshin, P.M. Tuts, S. Tzamarias, E. Tzovara, F. Ukegawa, P.A. Ulloa Poblete, E.N. Umaka, G. Unal, A. Undrus, G. Unel, J. Urban, P. Urrejola, G. Usai, R. Ushioda, M. Usman, Z. Uysal, V. Vacek, B. Vachon, T. Vafeiadis, A. Vaitkus, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, E. Valiente Moreno, A. Vallier, J.A. Valls Ferrer, D.R. Van Arneman, T.R. Van Daalen, A. Van Der Graaf, P. Van Gemmeren, M. Van Rijnbach, S. Van Stroud, I. Van Vulpen, P. Vana, M. Vanadia, W. Vandelli, E.R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E.W. Varnes, C. Varni, T. Varol, D. Varouchas, L. Varriale, K.E. Varvell, M.E. Vasile, L. Vaslin, G.A. Vasquez, A. Vasyukov, L.M. Vaughan, R. Vavricka, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M.J. Veen, I. Veliscek, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, S. Ventura Gonzalez, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, J.C. Vermeulen, C. Vernieri, M. Vessella, M.C. Vetterli, A. Vgenopoulos, N. Viaux Maira, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E.M. Villhauer, E. Vilucchi, M.G. Vincter, A. Visibile, C. Vittori, I. Vivarelli, E. Voevodina, F. Vogel, J.C. Voigt, P. Vokac, Yu. Volkotrub, J. Von Ahnen, E. Von Toerne, B. Vormwald, V. Vorobel, K. Vorobev, M. Vos, K. Voss, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, M. Vreeswijk, N.K. Vu, R. Vuillermet, O. Vujinovic, I. Vukotic, S. Wada, C. Wagner, J.M. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, M. Wakida, J. Walder, R. Walker, W. Walkowiak, A. Wall, E.J. Wallin, T. Wamorkar, A.Z. Wang, C. Wang, H. Wang, J. Wang, P. Wang, R. Wang, S.M. Wang, S. Wang, T. Wang, W.T. Wang, W. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, R.J. Ward, N. Warrack, S. Waterhouse, A.T. Watson, H. Watson, M.F. Watson, E. Watton, G. Watts, B.M. Waugh, J.M. Webb, C. Weber, H.A. Weber, M.S. Weber, S.M. Weber, C. Wei, Y. Wei, A.R. Weidberg, E.J. Weik, J. Weingarten, C. Weiser, C.J. Wells, T. Wenaus, B. Wendland, T. Wengler, N.S. Wenke, N. Wermes, M. Wessels, A.M. Wharton, A.S. White, A. White, M.J. White, D. Whiteson, L. Wickremasinghe, W. Wiedenmann, M. Wielers, C. Wiglesworth, D.J. Wilbern, H.G. Wilkens, J.J.H. Wilkinson, D.M. Williams, H.H. Williams, S. Williams, S. Willocq, B.J. Wilson, P.J. Windischhofer, F.I. Winkel, F. Winklmeier, B.T. Winter, J.K. Winter, M. Wittgen, M. Wobisch, T. Wojtkowski, Z. Wolffs, J. Wollrath, M.W. Wolter, H. Wolters, M.C. Wong, E.L. Woodward, S.D. Worm, B.K. Wosiek, K.W. Woźniak, S. Wozniewski, K. Wraight, C. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, M. Xie, S. Xin, A. Xiong, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. Yeo, M.R. Yexley, T.P. Yildirim, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z.K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search for Higgs boson pair production via vector-boson fusion is performed in the Lorentz-boosted regime, where a Higgs boson candidate is reconstructed as a single large-radius jet, using 140 fb−1 of proton–proton collision data at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Only Higgs boson decays into bottom quark pairs are considered. The search is particularly sensitive to the quartic coupling between two vector bosons and two Higgs bosons relative to its Standard Model prediction, κ2V. This study constrains κ2V to 0.55
Published: 2024
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15. Understanding ground-nesting habitat selection by waterbirds to prioritize invasive predator control on islands

Author: Valeria Gómez-Silva, Ramiro D. Crego, Fabian M. Jaksic, Gabriela Flores-Brenner, and Elke Schüttler
Subjects: American mink, Cape Horn, Chile, Chloephaga picta, Conservation, Neogale vison, Nest occupancy, Ecology, QH540-549.5
Abstract: The introduction of carnivores to islands affects the conservation status of native prey. For two decades, American mink (Neogale vison) has expanded its distribution in the sub-Antarctic archipelago of Austral Patagonia, while preying on nests of solitary ground-nesting birds. Here, upland geese (Chloephaga picta) and flightless steamer ducks (Tachyeres pteneres) are naïve to such predation risk because of the lack of native terrestrial predators. We used nest occupancy models to reveal preferred breeding habitats of those two ground-nesting waterbirds to prioritize areas for future mink control programs. We searched for nests along 80 transects on Navarino Island, southernmost Chile, and 11 transects on 10 nearby islets (3 ± 2.9 ha). Our results showed that islets were essential for breeding in comparison to the main island (5.3 nests/km versus 0.8 nests/km, respectively). The occupancy models revealed that islets were particularly important for flightless steamer ducks, endemic to western Patagonia. As breeding habitat, upland geese preferred medium-dense shrubland, and flightless steamer ducks preferred rocky coastlines. Nest detection was negatively affected by dense vegetation and, in the case of the upland geese, towards the end of the survey. Ten camera traps (n = 385 trap nights) revealed mink presence on all islets, highlighting their capacity to swim in cold water, up to 340 m distance from the main island. We conclude that islets represent breeding refuges for ground-nesting waterbirds and therefore advocate allocating resources for mink control during the warm season on islets. We also provide predictive maps of nesting habitat preference of upland geese and flightless steamer ducks for conservation managers to focus their often scarce human and financial resources on areas critical for breeding. Finally, we argue that detection probability should be an integral part of bird breeding studies, which can be methodologically achieved through targeting transects, not nests, as sample units.
Published: 2024
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16. Search for pair-produced higgsinos decaying via Higgs or Z bosons to final states containing a pair of photons and a pair of b-jets with the ATLAS detector

Author: G. Aad, B. Abbott, K. Abeling, N.J. Abicht, S.H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, A.C. Abusleme Hoffman, B.S. Acharya, C. Adam Bourdarios, L. Adamczyk, L. Adamek, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, A. Alfonsi, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Alvarez Fernandez, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, S.P. Amor Dos Santos, K.R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, M.T. Anthony, E. Antipov, M. Antonelli, D.J.A. Antrim, F. Anulli, M. Aoki, T. Aoki, J.A. Aparisi Pozo, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, N. Aranzabal, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, A.J. Armbruster, O. Arnaez, H. Arnold, Z.P. Arrubarrena Tame, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, K. Assamagan, R. Astalos, S. Atashi, R.J. Atkin, M. Atkinson, N.B. Atlay, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, P. Bagnaia, M. Bahmani, A.J. Bailey, V.R. Bailey, J.T. Baines, L. Baines, C. Bakalis, O.K. Baker, E. Bakos, D. Bakshi Gupta, R. Balasubramanian, E.M. 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Beloborodov, N.L. Belyaev, D. Benchekroun, F. Bendebba, Y. Benhammou, M. Benoit, J.R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F.U. Bernlochner, F. Bernon, T. Berry, P. Berta, A. Berthold, I.A. Bertram, S. Bethke, A. Betti, A.J. Bevan, M. Bhamjee, S. Bhatta, D.S. Bhattacharya, P. Bhattarai, V.S. Bhopatkar, R. Bi, R.M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, T.R.V. Billoud, M. Bindi, A. Bingul, C. Bini, A. Biondini, C.J. Birch-sykes, G.A. Bird, M. Birman, M. Biros, T. Bisanz, E. Bisceglie, D. Biswas, A. Bitadze, K. Bjørke, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, J. Blumenthal, G.J. Bobbink, V.S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A.G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C.D. Booth, A.G. Borbély, I.S. Bordulev, H.M. Borecka-Bielska, L.S. Borgna, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J.D. 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Wosiek, K.W. Woźniak, S. Wozniewski, K. Wraight, C. Wu, J. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, X. Xiao, M. Xie, X. Xie, S. Xin, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, N. Yamaguchi, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, Y.C. Yap, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. Yeo, M.R. Yexley, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, Y. Yu, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, P. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search is presented for the pair production of higgsinos χ˜ in gauge-mediated supersymmetry models, where the lightest neutralinos χ˜10 decay into a light gravitino G˜ in association with either a Higgs h or a Z boson. The search is performed with the ATLAS detector at the Large Hadron Collider using 139 fb−1 of proton–proton collisions at a centre-of-mass energy of s=13TeV. It targets final states in which a Higgs boson decays into a photon pair, while the other Higgs or Z boson decays into a bb¯ pair, with missing transverse momentum associated with the two gravitinos. Search regions dependent on the amount of missing transverse momentum are defined by the requirements that the diphoton mass should be consistent with the mass of the Higgs boson, and the bb¯ mass with the mass of the Higgs or Z boson. The main backgrounds are estimated with data-driven methods using the sidebands of the diphoton mass distribution. No excesses beyond Standard Model expectations are observed and higgsinos with masses up to 320GeV are excluded, assuming a branching fraction of 100% for χ˜10→hG˜. This analysis excludes higgsinos with masses of 130GeV for branching fractions to hG˜ as low as 36%, thus providing complementarity to previous ATLAS searches in final states with multiple leptons or multiple b-jets, targeting different decays of the electroweak bosons.
Published: 2024
Full Text: View/download PDF

17. Search for heavy Majorana neutrinos in e±e± and e±μ± final states via WW scattering in pp collisions at s=13 TeV with the ATLAS detector

Author: G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N.J. Abicht, S.H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B.S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, S. Aktas, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, Z.L. Alegria, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z.M.K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, K.J. Amirie, S.P. Amor Dos Santos, K.R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, A.C. Anderson, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S.J. Arbiol Val, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, R.A. Ashby Pickering, K. Assamagan, R. Astalos, K.S.V. Astrand, S. Atashi, R.J. Atkin, M. Atkinson, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T.M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J.T. Baines, L. Baines, O.K. Baker, E. Bakos, D. 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Xiong, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B.K. Yeo, M.R. Yexley, T.P. Yildirim, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z.K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search for heavy Majorana neutrinos in scattering of same-sign W boson pairs in proton–proton collisions at s=13 TeV at the LHC is reported. The dataset used corresponds to an integrated luminosity of 140 fb−1, collected with the ATLAS detector during 2015–2018. The search is performed in final states including a same-sign ee or eμ pair and at least two jets with large invariant mass and a large rapidity difference. No significant excess of events with respect to the Standard Model background predictions is observed. The results are interpreted in a benchmark scenario of the Phenomenological Type-I Seesaw model. New constraints are set on the values of the |VeN|2 and |VeNVμN⁎| parameters for heavy Majorana neutrino masses between 50 GeV and 20 TeV, where VℓN is the matrix element describing the mixing of the heavy Majorana neutrino mass eigenstate with the Standard Model neutrino of flavour ℓ=e,μ. The sensitivity to the Weinberg operator is investigated and constraints on the effective ee and eμ Majorana neutrino masses are reported. The statistical combination of the ee and eμ channels with the previously published μμ channel is performed.
Published: 2024
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18. Evaluation of kefir grain microbiota, grain viability, and bioactivity from fermenting dairy processing by-products

Author: Chloe J. McGovern, Brianda D. González-Orozco, and Rafael Jiménez-Flores
Subjects: kefir grain microbiota, metagenomics, dairy by-products, novel dairy beverage, kefir fermentation, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract: ABSTRACT: Four dairy foods processing by-products (acid whey permeate [AWP], buttermilk [BM], sweet whey permeate [SWP], and sweet whey permeate with added milk fat globule ingredient [SWP+MFGM]) were fermented for 4 wk and compared with traditional kefir milks for production of novel kefir-like dairy products. Sweet whey permeates and SWP supplemented with 1.5% milk fat globule membrane (MFGM) proved to be the most viable by-products for kefir grain fermentation, exhibiting diverse abundance of traditional kefir microorganisms and positive indicators of bioactive properties. Grain viability was assessed with shotgun metagenomics, texture profile analysis, live cell counts, and scanning electron microscopy. Assessed bioactivities of the kefir-like products included antibacterial, antioxidant, potential anticancerogenic properties, and membrane barrier effects on human colorectal adenocarcinoma Caco-2 cells. All kefir grains were most abundant in Lactobacillus kefiranofaciens when analyzed with shotgun metagenomics. When analyzed with live cell counts on selective media, AWP kefir-like product had no countable Lactococcus spp., indicating suboptimal conditions for kefir grain microbiota survival and application for fermented dairy starter culture bacterium. Live cell counts were affirmed with kefir grain surface scanning electron microscopy images. The SWP treatment had the most adhesive kefir grain surface, and SWP+MFGM had the largest exopolysaccharide yield from grain extraction. All kefir and kefir-like products were able to achieve a 6-log reduction against Listeria innocua and Escherichia coli. Traditional milk kefirs had the highest antioxidant capacity for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; ABTS) assay. The AWP formulation had a significantly higher DPPH antioxidant activity compared with the other kefir and kefir-like products, and SWP had the lowest Trolox equivalence concentration in the ABTS assay. Sweet whey and supplemented milk fat sweet whey had upregulation of Cldn-1 and Ocln-1 gene expression, which correspond with a significant increase in transepithelial electrical resistance.
Published: 2024
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19. Reduction in the antigenicity of beta-lactoglobulin in whole milk powder via supercritical CO2 treatment

Author: Rahul Venkatram, Israel García-Cano, and Rafael Jiménez-Flores
Subjects: beta-lactoglobulin, antigenicity, lactosylation, caprylation, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract: ABSTRACT: Cow milk allergy is a common phenomenon experienced in early childhood (
Published: 2024
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20. The introduction of microvascular free tissue transfer in primary burn reconstruction. Experience report of the national burn center in Chile

Author: Soto Carolina, Dona Jimena, Alzate Adriana, Troncoso Ekaterina, Hurtado María José, González Diego, Calcagno Manuel, Calderón María Elsa, Flores Nicolás, and Ríos Marco
Subjects: Acute burns, Microsurgery, Reconstruction, Microvascular free tissue transfer, Dermatology, RL1-803, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Background: Surgical debridement and split thickness graft is the most common treatment for acute burn patients that require surgery. However, there is a relevant minority that will require more complex reconstructive options. Microsurgery has evolved as a valuable tool in the acute setting allowing early closure of complex wounds in order to avoid infection, maintain function and even for limb salvage in one stage reconstruction. We present our experience in the management of severely acute burned patients with free flaps, flap survival rate and complications in Chile’s National Health service. Method: We performed a retrospective analysis of all major burn patients admitted in our unit who received a microsurgical flap in the period between april 2019 and march 2023. Data was collected on patient sex, age, mechanism of injury, total burned surface area (TBSA), location of the defect, days to reconstruction, flaps used, operatory time, flap survival and complications. Results: In the study period we had 925 admissions. A total of 36 patients had 42 free flaps (5,1%). All but two patients were male (95 %), mean age 46 years (range 20–––76 years). Total body surface area burned averaged 14 % (range 1–64 %). The majority of injuries were caused by high voltage electricity (59 %) and fire (33 %). 59 % compromised lower limbs and 31 % upper limbs. In 81 % of the cases anterolateral thigh flaps were used. Mean time to reconstruction was 39 days(range 1–64 days), we had 9 complications (21 %) and only one flap was lost (2,9%). Discussion: The introduction of free flaps in the burn reconstruction field was first described in sequelae management. In the acute phase it has also proven to be safe and feasible with a surgical indication of 1,5% to 2% of the admissions in different series. In our unit, 5,1% of our admissions required it, with a low flap loss rate. The increased confidence for its use in the acutely burned setting allowed us to achieve complex coverage while maintaining surgical risk and an internationally acceptable rate of losses and complications. Free flaps cpnstitute an active approach in the classical treatment of this pathology pushing the boundaries in the local environment.
Published: 2024
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21. Timeliness of surgery for early-stage lung cancer: Patient factors and predictorsCentral MessagePerspective

Author: Jeffrey Zhu, MSPH, Sydney Kantor, MBA, Jiafang Zhang, MS, Rowena Yip, PhD, MPH, Raja M. Flores, MD, Claudia I. Henschke, PhD, MD, and David F. Yankelevitz, MD
Subjects: delays, early-stage lung cancer, lung cancer, surgical delays, time to treatment, time to treatment initiation, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811
Abstract: Objectives: Time-to-treatment initiation is an important consideration for patients undergoing thoracic surgery for early-stage lung cancer because delays have the potential to adversely affect outcomes. This study seeks to quantify time-to-treatment initiation for patients with clinical stage I lung cancer, explore patient factors and predictors that lead to an increased time-to-treatment initiation, and compare surgeon perception of appropriate time-to-treatment initiation to the results. Methods: Time-to-treatment initiation was determined for patients enrolled in the Mount Sinai Initiative for Early Lung Cancer Research on Treatment study who underwent surgical resection for clinical stage I lung cancer between March 2016 and December 2021. The following dates were determined: (1) date of first suspicious radiologic imaging, (2) date of first biopsy, and (3) date of surgery. A total of 15 thoracic surgeons who participated in the Mount Sinai Initiative for Early Lung Cancer Research on Treatment were assessed on their perception on time-to-treatment initiation. Results: For 638 patients, median time from first suspicious imaging findings to biopsy was 40 days, biopsy to surgery was 37 days, and suspicious imaging to surgery was 84 days. Significant factors that resulted in longer time-to-treatment initiation in the multivariate analysis were African American or Black race (P = .005), vascular disease (P = .01), and median household income less than $75,000 (P = .04). Although the surgeon's perception was that the average time from biopsy to surgery was 28 days, it was longer for 63.5% of participants; surgeon perception of maximum time between diagnosis and surgery was 84 days and longer for 28.7% of participants. Conclusions: Patient factors such as race, income, and comorbidities were found to have differences in time-to-treatment initiation. Delays to surgery exceeded the expectations of thoracic surgeons.
Published: 2024
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22. Pseudomonas aeruginosa strains isolated from animal with high virulence genes content and highly sensitive to antimicrobials

Author: Rosario Morales-Espinosa, Gabriela Delgado, Fernando Espinosa-Camacho, Alejandro Flores-Alanis, Cristina Rodriguez, Jose L. Mendez, Alberto Gonzalez-Pedraza, and Alejandro Cravioto
Subjects: Pseudomonas aeruginosa, Animal infections, Highly sensitive to antimicrobials, Microbiology, QR1-502
Abstract: ABSTRACT: Objectives: P. aeruginosa is one of the most metabolically versatile bacteria having the ability to survive in multiple environments through its accessory genome. An important hallmark of P. aeruginosa is the high level of antibiotic resistance, which often makes eradication difficult and sometimes impossible. Evolutionary forces have led to this bacterium to develop high antimicrobial resistance with a variety of elements contributing to both intrinsic and acquired resistance. The objectives were to genetically and phenotypically characterizer P. aeruginosa strains isolated from companion animals of different species. Methods: We characterized a collection of 39 P. aeruginosa strains isolated from infected animals. The genetic characterization was in relation to chromosomal profile by PFGE; content of virulence gene; presence of genomic islands (GIs); genes of the cytotoxins exported by T3SS: exoU, exoS, exoT and exoY; and type IV pili allele. The phenotypic characterization was based on patterns of susceptibility to different antimicrobials. Results: Each strain had a PFGE profile, a high virulence genes content, and a large accessory genome. However, most of the strains presented high sensitivity to almost all antimicrobials tested, showing no acquired resistance (no β-lactamases). The exception to this lack of resistance was seen with penicillin. Conclusions: P. aeruginosa could be a naturally sensitive bacterium to standard antimicrobials but could rapidly develop intrinsic and acquired resistance when the bacterium is exposed to pressure exerted by antibiotics, as observed in hospital settings.
Published: 2024
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23. Pediatric inflammatory multisystem syndrome in a patient with Hodgkin lymphoma: A case report

Author: Carlos Julian Díaz-Torres, Irina Katia Cano Flores, and Julio A. Poterico
Subjects: Lymphoma, Hodgkin, Pediatric inflammatory multisystem syndrome (PIMS), Pediatrics, RJ1-570
Abstract: Background: The inflammatory state of Hodgkin lymphoma can generate increases in inflammatory markers that can sometimes be attributed to an infection in these immunosuppressed patients. During the COVID-19 pandemic, the diagnosis and treatment of patients with hematological malignancies was complicated by the presence of SARS-CoV2. It could range from an asymptomatic presentation to a multisystem inflammatory syndrome known as the Pediatric inflammatory multisystem syndrome (PIMS). Case report: We present the case of a girl who, during the COVID-19 pandemic, was treated at our institution for lymphadenopathy and persistent fever. The febrile syndrome was attributed to intercurrent infection; however, despite antimicrobial coverage, fever persisted, and inflammatory markers increased. Although SARS-CoV2 was not detected in the samples, PIMS was clinically suspected. Treatment with human immunoglobulin and acetylsalicylic acid was administered. An improvement in the inflammatory parameters was observed, which allowed ruling out an opportunistic infection and initiating chemotherapy. Conclusion: A patient diagnosed with lymphoma and presenting with PIMS could have a synergic interaction of both conditions, resulting in an adverse outcome.
Published: 2024
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24. The leachate from the Urban Solid Waste Transfer Station produces neurotoxicity in Wistar rats

Author: Torres-González Omar Ricardo, Flores-Soto Mario Eduardo, Tejeda-Martínez Aldo Rafael, Sánchez-Hernández Iván Moisés, Chaparro-Huerta Verónica, Soria-Fregozo Cesar, González-Garibay Angélica Sofía, and Padilla-Camberos Eduardo
Subjects: Leachate, Landfill, In vivo, Neurotoxicity, Immunochemistry, Toxicology. Poisons, RA1190-1270
Abstract: Leachate from municipal solid waste is a mixture of xenobiotics capable of contaminating bodies of water and causing damage to the health of living beings that inhabit or consume contaminated water. A previous study revealed the presence of heavy metals in Urban Solid Waste Transfer Station (USWTS) leachate above the permissible national and international limits. In the present study, we demonstrate that subchronic oral administration (5 and 25 % v/v) of leachate to male Wistar rats caused changes in the immunoreactivity of the glial markers: GFAP and Iba-1, accompanied by an increase in the expression of caspase-3, and a decrease in the expression of the NeuN protein. Results indicate that the heavy metals present in the leachate induced neuronal loss in the prefrontal cortex, suggesting that these contaminants can cause neurological problems in mammals that consume surface water with xenobiotics, since the leachate could contaminate water bodies and underground water.
Published: 2024
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25. Calcareous soil modified with metallic and organic ZnO nanoparticles limits photosynthetic pigment accumulation and macronutrient uptake in Swiss chard (Beta vulgaris var. cicla)

Author: Eddaliz García-Reyes, Josué I. García-López, Sonia N. Ramírez-Barrón, Antonio Flores-Naveda, Perpetuo Álvarez-Vázquez, Agustín Hernández-Juárez, and Enrique Díaz Barriga-Castro
Subjects: Macronutrient uptake, Photosynthetic pigments, Nanofertilizers, Zn accumulation, Botany, QK1-989
Abstract: Previous studies on the effects of zinc oxide nanoparticles have mainly examined controlled agricultural settings, failing to consider their behavior in real agricultural soil. As a result, our knowledge of their environmental impact remains incomplete. This study was specifically developed to observe the comparative effects of metallic zinc oxide nanoparticles, zinc sulfate, and zinc oxide green nanoparticles at different concentrations (25, 50, 75 and 100 mg of Zn kg−1 of soil) on growth parameters, the mineral content (N, P, K and Zn) in root and leaf, the content of chlorophyll a (CHLa), b (CHLb), and total (CHLt), and carotenoids in Swiss chard plants grown in calcareous soil. Leaf area and dry root weight increased by 23.27 % and 46.20 %, respectively, in zinc sulfate modified soil. Total chlorophyll and carotenoids also increased by 40.12 % and 32.59 %. The concentration of N, P, K and Zn in roots was 2.89, 1.74, 1.70 and 1.52 times higher, while in leaves, the concentration was 1.48, 1.44, 1.76 and 2.22 times higher in plants grown with zinc sulfate. The effects on plant growth can be attributed to the type of fertilizer used and its influence on macronutrient absorption in the soil. The utilization of zinc sulfate as a soil treatment led to elevated absorption of macronutrients and zinc, suggesting a connection between the fertilizer type and the crop’s agronomic and physiological reactions.
Published: 2024
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26. Large and reversible elastocaloric effect induced by low stress in a Ga-doped Ni-Mn-Ti alloy

Author: L.A. Ascencio de la Cruz, M. López-Medina, D.E. Soto-Parra, D. Ríos-Jara, J.P. Camarillo-Garcia, and H. Flores-Zúñiga
Subjects: shape memory alloys (SMA), Ni-Mn-Ti-Ga alloy, Elastocaloric effect, Reversible isothermal entropy change, Thermal hysteresis, Physics, QC1-999
Abstract: The Solid-state cooling based on caloric effects is considered a potential alternative to conventional refrigeration technology, which uses ozone-depleting gases. Several shape memory alloys have attracted attention for solid-state cooling since they present a high reversibility of the caloric effect, which depends mainly on thermal hysteresis and sensitivity to the applied field. In the present work, a study substitution of Mn by Ga in the Ni50Mn34Ti16 alloy led to diminished thermal hysteresis in the martensitic transformation by 9 K. The elastocaloric effect, thermal and microstructure properties of a polycrystalline Ni50Mn32Ti16Ga2 alloy have been characterized. The elastocaloric effect was obtained indirectly from the length change as a function of temperature at constant stress. An isothermal entropy change (ΔSISO) of 23.0 J kg−1 K−1 during heating and 22.0 J kg−1 K−1 during cooling was observed for applied stress of 160 MPa. In addition, the ΔSISO is reversible for a temperature span between 287 and 319 K, reaching a maximum of 20.5 J kg−1 K−1 at 299 K. The thermal hysteresis changed slightly while the applied stress increased up to 160 MPa since the sensitivity of the martensitic transformation temperatures to stress was 0.150 K/MPa during cooling and 0.160 K/MPa during heating. The X-ray diffraction analysis revealed a mixture of B2-type cubic austenite, 5M modulated martensite, and a second intermetallic phase identified as Ni3Ti. All these results were obtained around room temperature.
Published: 2024
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27. Management of waste containing polybrominated diphenyl ethers: A review

Author: Olga Kostenko, Lisveth Flores del Pino, Paola Jorge-Montalvo, and Lizardo Visitación-Figueroa
Subjects: Persistent organic pollutants, Pretreatment, Pyrolysis, Waste management cycle, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Polybrominated diphenyl ethers (PBDEs) are substances used as flame retardants that can be released into the environment through volatilization, leaching, and abrasion throughout the useful life of the articles that contain them, especially at the end of their life cycle because PBDEs do not chemically bind to the initial materials (electrical and electronic equipment, textiles, materials used in transport vehicles, toys, among others). Research has shown that the toxic effects and risks of PBDEs to ecosystems and human health are greater than their benefits owing to their neurotoxicity, toxicity to the endocrine and reproductive systems, and possible carcinogenicity. This review shows the current situation of management of waste containing PBDEs (plastics, sludge, soil, and ash) and the characterization, valorization, treatment, and final disposal of these wastes, to minimize their impacts on ecosystems and human health are analyzed. Wastes with concentrations greater than 1000 mg/kg of PBDE should be considered as hazardous waste. This research identifies the methods available to reduce the risk in their management; at the same time, it provides innovative ideas for the integrated management of PBDE-containing wastes, prioritizing their valorization and disposal.
Published: 2024
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28. C19MC drives nucleolar invasion of mitochondria and meiotic nuclear division in human cancers

Author: Goodwin G. Jinesh, Marian T. Smallin, Nino Mtchedlidze, Marco Napoli, John H. Lockhart, Elsa R. Flores, and Andrew S. Brohl
Subjects: Cancer, Cell biology, Science
Abstract: Summary: The chromosome-19 miRNA cluster (C19MC) restricts viruses depending on the multinucleated state of placental trophoblasts. However, the relationship of C19MC to multinucleation is unknown. Here we show that C19MC is coexpressed in multiple cancer type subsets with meiosis-related genes. We discovered a novel meiosis-III that exhibits simultaneous progression of meiotic nuclear division (MND) and cytokinesis. C19MC promotes meiotic bridged-chromosomes to block MND and cytokinesis to generate multinucleated cells. MND starts with the invagination of nuclear membrane to form nucle(ol)ar invasive cytoplasm (NiC), mitochondria and protein cargoes. Aurora-B regulates the efflux of cargos from NiC, whereas C19MC, CDK1, and autophagy promote cargo influx to inflate NiC size for MND progression. Using CRISPR human genetic engineering we demonstrate that the C19MC expression is required for NiC-driven MND and multinucleation. This discovery has impacts on cancer-pathogen interactions, immunotherapy, vertical transmission of viruses, antiviral research and SpCas9-CRISPR therapeutics.
Published: 2024
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29. An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Author: Nian E. Zhou, Su Tang, Xuelin Bian, Maloy K. Parai, Inna V. Krieger, Armando Flores, Pradeep K. Jaiswal, Radha Bam, Jeremy L. Wood, Zhe Shi, Laura J. Stevens, Trevor Scobey, Meghan V. Diefenbacher, Fernando R. Moreira, Thomas J. Baric, Arjun Acharya, Joonyoung Shin, Manish M. Rathi, Karen C. Wolff, Laura Riva, Malina A. Bakowski, Case W. McNamara, Nicholas J. Catanzaro, Rachel L. Graham, David C. Schultz, Sara Cherry, Yoshihiro Kawaoka, Peter J. Halfmann, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan, and James C. Sacchettini
Subjects: CP: Microbiology, Biology (General), QH301-705.5
Abstract: Summary: Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a high-throughput screen to identify non-peptidic, non-covalent inhibitors of the SARS-CoV-2 main protease (Mpro), an essential enzyme in viral replication. NZ-804 was developed from a screening hit through iterative rounds of structure-guided medicinal chemistry. NZ-804 potently inhibits SARS-CoV-2 Mpro (0.009 μM IC50) as well as SARS-CoV-2 replication in human lung cell lines (0.008 μM EC50) and primary human airway epithelial cell cultures. Antiviral activity is maintained against distantly related sarbecoviruses and endemic human CoV OC43. In SARS-CoV-2 mouse and hamster disease models, NZ-804 therapy given once or twice daily significantly diminished SARS-CoV-2 replication and pathogenesis. NZ-804 synthesis is low cost and uncomplicated, simplifying global production and access. These data support the exploration of NZ-804 as a therapy for COVID-19 and future emerging sarbecovirus infections.
Published: 2024
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30. Palmitoylcarnitine impairs immunity in decompensated cirrhosis

Author: Ingrid Wei Zhang, María Belén Sánchez-Rodríguez, Cristina López-Vicario, Mireia Casulleras, Marta Duran-Güell, Roger Flores-Costa, Ferran Aguilar, Michael Rothe, Paula Segalés, Carmen García-Ruiz, José C. Fernández-Checa, Jonel Trebicka, Vicente Arroyo, and Joan Clària
Subjects: Immune cells, Acute decompensation of cirrhosis, Acylcarnitines, Mitochondrial dysfunction, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Background & Aims: In patients with cirrhosis, acute decompensation (AD) correlates with a hyperinflammatory state driven by mitochondrial dysfunction, which is a significant factor in the progression toward acute-on-chronic liver failure (ACLF). Elevated circulating levels of acylcarnitine, indicative of mitochondrial dysfunction, are predictors of mortality in ACLF patients. Our hypothesis posits that acylcarnitines not only act as biomarkers, but also actively exert detrimental effects on circulating immune cells. Methods: Plasma acylcarnitine levels were measured in 20 patients with AD cirrhosis and 10 healthy individuals. The effects of selected medium- and long-chain acylcarnitines on mitochondrial function were investigated in peripheral leucocytes from healthy donors by determining mitochondrial membrane potential (Δψm) and mitochondrial respiration using the JC-1 dye and Agilent Seahorse XF technology. Changes regarding mitochondrial ultrastructure and redox systems were assessed by transmission electron microscopy and gene and protein expression analysis. Results: Plasma levels of several acylcarnitine species were significantly elevated in patients with AD cirrhosis compared with healthy individuals, alongside increased levels of inflammatory mediators (cytokines and chemokines). Notably, the long-chain acylcarnitine palmitoylcarnitine (C16:0-carnitine, 1.51-fold higher, p = 0.0059) impaired Δψm and reduced the spare respiratory capacity of peripheral mononuclear leucocytes. Additionally, C16:0-carnitine induced mitochondrial oxidative stress, suppressed the expression of the antioxidant gene HMOX1, and increased CXCL8 expression and IL-8 release. Etomoxir, which blocks acylcarnitine entry into the mitochondria, reversed the suppression of HMOX1. Similarly, trimetazidine, a fatty acid beta-oxidation inhibitor, prevented C16:0-carnitine-induced CXCL8 expression. Importantly, oxidative stress and Δψm impairment caused by C16:0-carnitine were less severe in the presence of albumin, a standard therapy for AD cirrhosis. Conclusions: Our findings suggest that long-chain acylcarnitines induce mitochondrial injury in immune cells, thereby contributing to the development of immune dysfunction associated with cirrhosis. Impact and implications: Patients with acute decompensation of cirrhosis and acute-on-chronic liver failure (ACLF) display a systemic hyperinflammatory state and leukocyte mitochondrial dysfunction. We discovered that apart from being increased in the circulation of these patients, the long-chain palmitoylcarnitine is able to elicit cytokine secretion paired with mitochondrial dysfunction in leukocytes from healthy donors. In particular, we show that inhibiting the metabolism of palmitoylcarnitine could reverse these detrimental effects. Our findings underline the importance of immunometabolism as a treatment target in patients with acute decompensation of cirrhosis and ACLF.
Published: 2024
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31. Sex, vaccination status, and comorbidities influence long COVID persistence

Author: Trevon Fuller, Roxana Flores Mamani, Heloísa Ferreira Pinto Santos, Otávio Melo Espíndola, Lusiele Guaraldo, Carolina Lopes Melo, Michele Fernanda Borges Da Silva, Guilherme Amaral Calvet, Leonardo Soares Bastos, Marília Sá Carvalho, and Patrícia Brasil
Subjects: Post-Acute COVID-19 Syndrome, Immunoglobulin G, Cohort Studies, Risk Factors, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract: Background: There is interest in the public health impact of Long COVID, defined as symptoms that persist or begin after SARS-CoV-2 infection. We aimed to identify demographic and clinical risk factors associated with Long COVID over time in an Upper Middle-Income Country (UMIC) and potential biomarkers predictive of symptom trajectory. Methods: Prospective cohort study of adults with mild SARS-COV-2 during the Omicron period. We tracked symptom persistence and IgG antibody titers against the spike S1 subunit. Results: Of 383 participants, 276 had confirmed SARS-CoV-2 infection. Long COVID persisted for ≥ two months in 21 % and ≥ 12 months in 5 %. The most common symptoms were fatigue, upper respiratory symptoms, and myalgia/arthralgia: 15 % had fatigue for ≥ one month, 10 % for ≥ two months, and 5 % ≥ three months. Upper respiratory symptoms lasted ≥ one month in 17 %, ≥ two months in 7 %, and ≥ three months in 3 %. Fully 9 % reported myalgia/arthralgia lasting ≥ one month, 6 % ≥ two months, and 4 % ≥ three months. Risk factors for symptom persistence included female sex, not being fully vaccinated, and comorbidities. Participants experiencing persistent fatigue had lower anti-S1 IgG titers. Conclusions: In this population, symptom persistence declined after the acute phase, but 5 % of participants did not fully recover. Even in a population that was almost fully vaccinated, women, individuals with comorbidities, and the few remaining people who were unvaccinated were at greater risk for Long COVID. Immunoglobulins may have utility as a biomarker of Long COVID fatigue in this population.
Published: 2024
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32. Measurement of the impact-parameter dependent azimuthal anisotropy in coherent ρ0 photoproduction in Pb–Pb collisions at sNN=5.02 TeV

Author: S. Acharya, D. Adamová, A. Agarwal, G. Aglieri Rinella, L. Aglietta, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S.U. Ahn, I. Ahuja, A. Akindinov, V. Akishina, M. Al-Turany, D. Aleksandrov, B. Alessandro, H.M. Alfanda, R. Alfaro Molina, B. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, G. Alocco, T. Alt, A.R. Altamura, I. Altsybeev, J.R. Alvarado, C.O.R. Alvarez, M.N. Anaam, C. Andrei, N. Andreou, A. Andronic, E. Andronov, V. Anguelov, F. Antinori, P. Antonioli, N. Apadula, L. Aphecetche, H. Appelshäuser, C. Arata, S. Arcelli, M. Aresti, R. Arnaldi, J.G.M.C.A. Arneiro, I.C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, M.D. Azmi, H. Baba, A. Badalà, J. Bae, Y.W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, D. Banerjee, Z. Banoo, V. Barbasova, F. Barile, L. Barioglio, M. Barlou, B. Barman, G.G. Barnaföldi, L.S. Barnby, E. Barreau, V. Barret, L. Barreto, C. Bartels, K. Barth, E. Bartsch, N. Bastid, S. Basu, G. Batigne, D. Battistini, B. Batyunya, D. Bauri, J.L. Bazo Alba, I.G. Bearden, C. Beattie, P. Becht, D. Behera, I. Belikov, A.D.C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, L.G.E. Beltran, Y.A.V. Beltran, G. Bencedi, A. Bensaoula, S. Beole, Y. Berdnikov, A. Berdnikova, L. Bergmann, M.G. Besoiu, L. Betev, P.P. Bhaduri, A. Bhasin, B. Bhattacharjee, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, A.P. Bigot, A. Bilandzic, G. Biro, S. Biswas, N. Bize, J.T. Blair, D. Blau, M.B. Blidaru, N. Bluhme, C. Blume, G. Boca, F. Bock, T. Bodova, J. Bok, L. Boldizsár, M. Bombara, P.M. Bond, G. Bonomi, H. Borel, A. Borissov, A.G. Borquez Carcamo, H. Bossi, E. Botta, Y.E.M. Bouziani, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G.E. Bruno, V.D. Buchakchiev, M.D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, P. Buhler, N. Burmasov, Z. Buthelezi, A. Bylinkin, S.A. Bysiak, J.C. Cabanillas Noris, M.F.T. Cabrera, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J.M.M. Camacho, P. Camerini, F.D.M. Canedo, S.L. Cantway, M. Carabas, A.A. Carballo, F. Carnesecchi, R. Caron, L.A.D. Carvalho, J. Castillo Castellanos, M. Castoldi, F. Catalano, S. Cattaruzzi, C. Ceballos Sanchez, R. Cerri, I. Chakaberia, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhay, S. Chattopadhyay, M. Chen, T. Cheng, C. Cheshkov, V. Chibante Barroso, D.D. Chinellato, E.S. Chizzali, J. Cho, S. Cho, P. Chochula, Z.A. Chochulska, D. Choudhury, P. Christakoglou, C.H. Christensen, P. Christiansen, T. Chujo, M. Ciacco, C. Cicalo, M.R. Ciupek, G. Clai, F. Colamaria, J.S. Colburn, D. Colella, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J.G. Contreras, M.L. Coquet, P. Cortese, M.R. Cosentino, F. Costa, S. Costanza, C. Cot, J. Crkovská, P. Crochet, R. Cruz-Torres, P. Cui, M.M. Czarnynoga, A. Dainese, G. Dange, M.C. Danisch, A. Danu, P. Das, S. Das, A.R. Dash, S. Dash, A. De Caro, G. de Cataldo, J. de Cuveland, A. De Falco, D. De Gruttola, N. 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Wright, W. Wu, Y. Wu, Z. Xiong, R. Xu, A. Yadav, A.K. Yadav, Y. Yamaguchi, S. Yang, S. Yano, E.R. Yeats, Z. Yin, I.-K. Yoo, J.H. Yoon, H. Yu, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, F. Zanone, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, C. Zhang, L. Zhang, M. Zhang, S. Zhang, X. Zhang, Y. Zhang, Z. Zhang, M. Zhao, V. Zherebchevskii, Y. Zhi, D. Zhou, Y. Zhou, J. Zhu, S. Zhu, Y. Zhu, S.C. Zugravel, and N. Zurlo
Subjects: Physics, QC1-999
Abstract: This Letter presents the first measurement of the impact-parameter dependent angular anisotropy in the decay of coherently photoproduced ρ0 mesons. The ρ0 mesons are reconstructed through their decay into pion pairs. The measured anisotropy corresponds to the amplitude of the cos⁡(2ϕ) modulation, where ϕ is the angle between the two vectors formed by the sum and the difference of the transverse momenta of the pions, respectively. The measurement was performed by the ALICE Collaboration at the LHC using data from ultraperipheral Pb–Pb collisions at a center-of-mass energy of sNN=5.02 TeV per nucleon pair. Different impact-parameter regions are selected by classifying the events in nuclear-breakup classes. The amplitude of the cos⁡(2ϕ) modulation is found to increase by about one order of magnitude from large to small impact parameters. Theoretical calculations describe the measured cos⁡(2ϕ) anisotropy and its impact-parameter dependence as the result of a quantum interference effect at the femtometer scale, arising from the ambiguity regarding which of the nuclei is the photon source in the interaction.
Published: 2024
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33. Measurement of the polarizations of prompt and non-prompt Image 1 and ψ(2S) mesons produced in pp collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A.K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F.A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M.A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. 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Zhang, M. Bachtis, R. Cousins, A. Datta, G. Flores Avila, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, A. Nunez Del Prado, D. Saltzberg, V. Valuev, R. Clare, J.W. Gary, M. Gordon, G. Hanson, W. Si, A. Aportela, A. Arora, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, Y. Gu, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, K. Downham, C. Grieco, J. Incandela, A.J. Li, P. Masterson, H. Mei, J. Richman, S.N. Santpur, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, T.Á. Vámi, S. Wang, D. Zhang, A. Bornheim, O. Cerri, A. Latorre, J. Mao, H.B. Newman, G. Reales Gutiérrez, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, P. Bryant, M. Cremonesi, V. Dutta, T. Ferguson, T.A. Gómez Espinosa, A. Harilal, A. Kallil Tharayil, C. Liu, T. Mudholkar, S. Murthy, P. Palit, K. Park, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hart, A. Hassani, G. Karathanasis, N. Manganelli, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, D. Zuolo, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, S. Hogan, P. Kotamnives, J. Monroy, M. Oshiro, J.R. Patterson, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, S. Norberg, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, M. Safdari, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, S. Rosenzweig, Y. Takahashi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, M. Wulansatiti, R. Yohay, B. Alsufyani, M.M. Baarmand, S. Butalla, S. Das, T. Elkafrawy, M. Hohlmann, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C.E. Gerber, M. Hawksworth, A. Hingrajiya, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, E. Prifti, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, M.A. Wadud, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, S. Arteaga Escatel, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, J. Natoli, D. Roy, G. Sorrentino, A. Baden, A. Belloni, J. Bistany-riebman, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, B. Kronheim, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, I.A. Cali, P.c. Chou, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mcginn, A. Novak, C. Paus, C. Roland, G. Roland, S. Rothman, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, R. Rusack, R. Saradhy, N. Strobbe, K. Bloom, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, H.w. Hsia, I. Iashvili, A. Kalogeropoulos, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, P. Young, G. Alverson, E. Barberis, J. Bonilla, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, D. Wood, J. Bueghly, S. Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, S. Malik, A.S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A.W. Jung, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, J. Lin, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, B. Chiarito, J.P. Chou, S.V. Clark, D. Gadkari, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, S. Konstantinou, I. Laflotte, A. Lath, R. Montalvo, K. Nash, J. Reichert, H. Routray, P. Saha, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, T. Akhter, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, N. Gogate, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Quarkonium production, Quarkonium polarization, Physics, QC1-999
Abstract: The polarizations of prompt and non-prompt Image 2 and ψ(2S) mesons are measured in proton-proton collisions at s=13 TeV, using data samples collected by the CMS experiment in 2017 and 2018, corresponding to a total integrated luminosity of 103.3fb−1. Based on the analysis of the dimuon decay angular distributions in the helicity frame, the polar anisotropy, λϑ, is measured as a function of the transverse momentum, pT, of the charmonium states, in the 25–120 and 20–100 GeV ranges for the Image 2 and ψ(2S), respectively. The non-prompt polarizations agree with predictions based on the hypothesis that, for pT≳25GeV, the non-prompt Image 2 and ψ(2S) are predominantly produced in two-body B meson decays. The prompt results clearly exclude strong transverse polarizations, even for pT exceeding 30 times the Image 2 mass, where λϑ tends to an asymptotic value around 0.3. Taken together with previous measurements, by CMS and LHCb at s=7 TeV, the prompt polarizations show a significant variation with pT, at low pT.
Published: 2024
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34. Research Note: A deep learning method segments chicken keel bones from whole-body X-ray images

Author: Moh Sallam, Samuel Coulbourn Flores, Dirk Jan de Koning, and Martin Johnsson
Subjects: keel bone, sternum, machine deep learning, segmentation, laying hen, Animal culture, SF1-1100
Abstract: ABSTRACT: Most commercial laying hens suffer from sternum (keel) bone damage including deviations and fractures. X-raying hens, followed by segmenting and assessing the keel bone, is a key to automating the monitoring of keel bone condition. The aim of the current work is to train a deep learning model to segment the keel bone out of whole-body x-ray images. We obtained full-body x-ray images of laying hens (n = 1,051) and manually drew the outline of the keel bone on each image. Using the annotated images, a U-net model was then trained to segment the keel bone. The proposed model was evaluated using 5-fold cross validation. We obtained high segmentation accuracy (Dice coefficients of 0.88–0.90) repeatably over several validation folds. In conclusion, automatic segmentation of the keel bone from full-body x-ray images is possible with good accuracy. Segmentation is a requirement for automated measurements of keel geometry and density, which can subsequently be connected to susceptibility to keel deviations and fractures.
Published: 2024
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35. Measurement of (anti)alpha production in central Pb–Pb collisions at sNN=5.02 TeV

Author: S. Acharya, D. Adamová, G. Aglieri Rinella, M. Agnello, N. Agrawal, Z. Ahammed, S. Ahmad, S.U. Ahn, I. Ahuja, A. Akindinov, M. Al-Turany, D. Aleksandrov, B. Alessandro, H.M. Alfanda, R. Alfaro Molina, B. Ali, A. Alici, N. Alizadehvandchali, A. Alkin, J. Alme, G. Alocco, T. Alt, A.R. Altamura, I. Altsybeev, J.R. Alvarado, M.N. Anaam, C. Andrei, N. Andreou, A. Andronic, E. Andronov, V. Anguelov, F. Antinori, P. Antonioli, N. Apadula, L. Aphecetche, H. Appelshäuser, C. Arata, S. Arcelli, M. Aresti, R. Arnaldi, J.G.M.C.A. Arneiro, I.C. Arsene, M. Arslandok, A. Augustinus, R. Averbeck, M.D. Azmi, H. Baba, A. Badalà, J. Bae, Y.W. Baek, X. Bai, R. Bailhache, Y. Bailung, R. Bala, A. Balbino, A. Baldisseri, B. Balis, D. Banerjee, Z. Banoo, F. Barile, L. Barioglio, M. Barlou, B. Barman, G.G. Barnaföldi, L.S. Barnby, E. Barreau, V. Barret, L. Barreto, C. Bartels, K. Barth, E. Bartsch, N. Bastid, S. Basu, G. Batigne, D. Battistini, B. Batyunya, D. Bauri, J.L. Bazo Alba, I.G. Bearden, C. Beattie, P. Becht, D. Behera, I. Belikov, A.D.C. Bell Hechavarria, F. Bellini, R. Bellwied, S. Belokurova, L.G.E. Beltran, Y.A.V. Beltran, G. Bencedi, S. Beole, Y. Berdnikov, A. Berdnikova, L. Bergmann, M.G. Besoiu, L. Betev, P.P. Bhaduri, A. Bhasin, M.A. Bhat, B. Bhattacharjee, L. Bianchi, N. Bianchi, J. Bielčík, J. Bielčíková, A.P. Bigot, A. Bilandzic, G. Biro, S. Biswas, N. Bize, J.T. Blair, D. Blau, M.B. Blidaru, N. Bluhme, C. Blume, G. Boca, F. Bock, T. Bodova, S. Boi, J. Bok, L. Boldizsár, M. Bombara, P.M. Bond, G. Bonomi, H. Borel, A. Borissov, A.G. Borquez Carcamo, H. Bossi, E. Botta, Y.E.M. Bouziani, L. Bratrud, P. Braun-Munzinger, M. Bregant, M. Broz, G.E. Bruno, M.D. Buckland, D. Budnikov, H. Buesching, S. Bufalino, P. Buhler, N. Burmasov, Z. Buthelezi, A. Bylinkin, S.A. Bysiak, J.C. Cabanillas Noris, M. Cai, H. Caines, A. Caliva, E. Calvo Villar, J.M.M. Camacho, P. Camerini, F.D.M. Canedo, S.L. Cantway, M. Carabas, A.A. Carballo, F. Carnesecchi, R. Caron, L.A.D. Carvalho, J. Castillo Castellanos, F. Catalano, C. Ceballos Sanchez, I. Chakaberia, P. Chakraborty, S. Chandra, S. Chapeland, M. Chartier, S. Chattopadhyay, T. Cheng, C. Cheshkov, B. Cheynis, V. Chibante Barroso, D.D. Chinellato, E.S. Chizzali, J. Cho, S. Cho, P. Chochula, D. Choudhury, P. Christakoglou, C.H. Christensen, P. Christiansen, T. Chujo, M. Ciacco, C. Cicalo, M.R. Ciupek, G. Clai, F. Colamaria, J.S. Colburn, D. Colella, M. Colocci, M. Concas, G. Conesa Balbastre, Z. Conesa del Valle, G. Contin, J.G. Contreras, M.L. Coquet, P. Cortese, M.R. Cosentino, F. Costa, S. Costanza, C. Cot, J. Crkovská, P. Crochet, R. Cruz-Torres, P. Cui, A. Dainese, M.C. Danisch, A. Danu, P. Das, S. Das, A.R. Dash, S. Dash, A. De Caro, G. de Cataldo, J. de Cuveland, A. De Falco, D. De Gruttola, N. De Marco, C. De Martin, S. De Pasquale, R. Deb, R. Del Grande, L. Dello Stritto, W. Deng, P. Dhankher, D. Di Bari, A. Di Mauro, B. Diab, R.A. Diaz, T. Dietel, Y. Ding, J. Ditzel, R. Divià, D.U. Dixit, Ø. Djuvsland, U. Dmitrieva, A. Dobrin, B. Dönigus, J.M. Dubinski, A. Dubla, S. Dudi, P. Dupieux, M. Durkac, N. Dzalaiova, T.M. Eder, R.J. Ehlers, F. Eisenhut, R. Ejima, D. Elia, B. Erazmus, F. Ercolessi, B. Espagnon, G. Eulisse, D. Evans, S. Evdokimov, L. Fabbietti, M. Faggin, J. Faivre, F. Fan, W. Fan, A. Fantoni, M. Fasel, A. Feliciello, G. Feofilov, A. Fernández Téllez, L. Ferrandi, M.B. Ferrer, A. Ferrero, C. Ferrero, A. Ferretti, V.J.G. Feuillard, V. Filova, D. Finogeev, F.M. Fionda, E. Flatland, F. Flor, A.N. Flores, S. Foertsch, I. Fokin, S. Fokin, E. Fragiacomo, E. Frajna, U. Fuchs, N. Funicello, C. Furget, A. Furs, T. Fusayasu, J.J. Gaardhøje, M. Gagliardi, A.M. Gago, T. Gahlaut, C.D. Galvan, D.R. Gangadharan, P. Ganoti, C. Garabatos, T. García Chávez, E. Garcia-Solis, C. Gargiulo, P. Gasik, A. Gautam, M.B. Gay Ducati, M. Germain, A. Ghimouz, C. Ghosh, M. Giacalone, G. Gioachin, P. Giubellino, P. Giubilato, A.M.C. Glaenzer, P. Glässel, E. Glimos, D.J.Q. Goh, V. Gonzalez, P. Gordeev, M. Gorgon, K. Goswami, S. Gotovac, V. Grabski, L.K. Graczykowski, E. Grecka, A. Grelli, C. Grigoras, V. Grigoriev, S. Grigoryan, F. Grosa, J.F. Grosse-Oetringhaus, R. Grosso, D. Grund, N.A. Grunwald, G.G. Guardiano, R. Guernane, M. Guilbaud, K. Gulbrandsen, T. Gündem, T. Gunji, W. Guo, A. Gupta, R. Gupta, K. Gwizdziel, L. Gyulai, C. Hadjidakis, F.U. Haider, S. Haidlova, M. Haldar, H. Hamagaki, A. Hamdi, Y. Han, B.G. Hanley, R. Hannigan, J. Hansen, J.W. Harris, A. Harton, M.V. Hartung, H. Hassan, D. Hatzifotiadou, P. Hauer, L.B. Havener, E. Hellbär, H. Helstrup, M. Hemmer, T. Herman, G. Herrera Corral, F. Herrmann, S. Herrmann, K.F. Hetland, B. Heybeck, H. Hillemanns, B. Hippolyte, F.W. Hoffmann, B. Hofman, G.H. Hong, M. Horst, A. Horzyk, Y. Hou, P. Hristov, C. Hughes, P. Huhn, L.M. Huhta, T.J. Humanic, A. Hutson, D. Hutter, M.C. Hwang, R. Ilkaev, H. Ilyas, M. Inaba, G.M. Innocenti, M. Ippolitov, A. Isakov, T. Isidori, M.S. Islam, M. Ivanov, V. Ivanov, K.E. Iversen, M. Jablonski, B. Jacak, N. Jacazio, P.M. Jacobs, S. Jadlovska, J. Jadlovsky, S. Jaelani, C. Jahnke, M.J. Jakubowska, M.A. Janik, T. Janson, S. Ji, S. Jia, A.A.P. Jimenez, F. Jonas, D.M. Jones, J.M. Jowett, J. Jung, M. Jung, A. Junique, A. Jusko, J. Kaewjai, P. Kalinak, A.S. Kalteyer, A. Kalweit, A. Karasu Uysal, D. Karatovic, O. Karavichev, T. Karavicheva, P. Karczmarczyk, E. Karpechev, M.J. Karwowska, U. Kebschull, R. Keidel, D.L.D. Keijdener, M. Keil, B. Ketzer, S.S. Khade, A.M. Khan, S. Khan, A. Khanzadeev, Y. Kharlov, A. Khatun, A. Khuntia, Z. Khuranova, B. Kileng, B. Kim, C. Kim, D.J. Kim, E.J. Kim, J. Kim, M. Kim, S. Kim, T. Kim, K. Kimura, S. Kirsch, I. Kisel, S. Kiselev, A. Kisiel, J.P. Kitowski, J.L. Klay, J. Klein, S. Klein, C. Klein-Bösing, M. Kleiner, T. Klemenz, A. Kluge, C. Kobdaj, T. Kollegger, A. Kondratyev, N. Kondratyeva, J. Konig, S.A. Konigstorfer, P.J. Konopka, G. Kornakov, M. Korwieser, S.D. Koryciak, A. Kotliarov, N. Kovacic, V. Kovalenko, M. Kowalski, V. Kozhuharov, I. Králik, A. Kravčáková, L. Krcal, M. Krivda, F. Krizek, K. Krizkova Gajdosova, M. Kroesen, M. Krüger, D.M. Krupova, E. Kryshen, V. Kučera, C. Kuhn, P.G. Kuijer, T. Kumaoka, D. Kumar, L. Kumar, N. Kumar, S. Kumar, S. Kundu, P. Kurashvili, A. Kurepin, A.B. Kurepin, A. Kuryakin, S. Kushpil, V. Kuskov, M. Kutyla, M.J. Kweon, Y. Kwon, S.L. La Pointe, P. La Rocca, A. Lakrathok, M. Lamanna, A.R. Landou, R. Langoy, P. Larionov, E. Laudi, L. Lautner, R. Lavicka, R. Lea, H. Lee, I. Legrand, G. Legras, J. Lehrbach, T.M. Lelek, R.C. Lemmon, I. León Monzón, M.M. Lesch, E.D. Lesser, P. Lévai, X. Li, B.E. Liang-gilman, J. Lien, R. Lietava, I. Likmeta, B. Lim, S.H. Lim, V. Lindenstruth, A. Lindner, C. Lippmann, D.H. Liu, J. Liu, G.S.S. Liveraro, I.M. Lofnes, C. Loizides, S. Lokos, J. Lömker, P. Loncar, X. Lopez, E. López Torres, P. Lu, F.V. Lugo, J.R. Luhder, M. Lunardon, G. Luparello, Y.G. Ma, M. Mager, A. Maire, E.M. Majerz, M.V. Makariev, M. Malaev, G. Malfattore, N.M. Malik, Q.W. Malik, S.K. Malik, L. Malinina, D. Mallick, N. Mallick, G. Mandaglio, S.K. Mandal, V. Manko, F. Manso, V. Manzari, Y. Mao, R.W. Marcjan, G.V. Margagliotti, A. Margotti, A. Marín, C. Markert, P. Martinengo, M.I. Martínez, G. Martínez García, M.P.P. Martins, S. Masciocchi, M. Masera, A. Masoni, L. Massacrier, O. Massen, A. Mastroserio, O. Matonoha, S. Mattiazzo, A. Matyja, C. Mayer, A.L. Mazuecos, F. Mazzaschi, M. Mazzilli, J.E. Mdhluli, Y. Melikyan, A. Menchaca-Rocha, J.E.M. Mendez, E. Meninno, A.S. Menon, M. Meres, Y. Miake, L. Micheletti, D.L. Mihaylov, K. Mikhaylov, D. Miśkowiec, A. Modak, B. Mohanty, M. Mohisin Khan, M.A. Molander, S. Monira, C. Mordasini, D.A. Moreira De Godoy, I. Morozov, A. Morsch, T. Mrnjavac, V. Muccifora, S. Muhuri, J.D. Mulligan, A. Mulliri, M.G. Munhoz, R.H. Munzer, H. Murakami, S. Murray, L. Musa, J. Musinsky, J.W. Myrcha, B. Naik, A.I. Nambrath, B.K. Nandi, R. Nania, E. Nappi, A.F. Nassirpour, A. Nath, C. Nattrass, M.N. Naydenov, A. Neagu, A. Negru, E. Nekrasova, L. Nellen, R. Nepeivoda, S. Nese, G. Neskovic, N. Nicassio, B.S. Nielsen, E.G. Nielsen, S. Nikolaev, S. Nikulin, V. Nikulin, F. Noferini, S. Noh, P. Nomokonov, J. Norman, N. Novitzky, P. Nowakowski, A. Nyanin, J. Nystrand, S. Oh, A. Ohlson, V.A. Okorokov, J. Oleniacz, A. Onnerstad, C. Oppedisano, A. Ortiz Velasquez, J. Otwinowski, M. Oya, K. Oyama, Y. Pachmayer, S. Padhan, D. Pagano, G. Paić, S. Paisano-Guzmán, A. Palasciano, S. Panebianco, H. Park, J. Park, J.E. Parkkila, Y. Patley, B. Paul, M.M.D.M. Paulino, H. Pei, T. Peitzmann, X. Peng, M. Pennisi, S. Perciballi, D. Peresunko, G.M. Perez, Y. Pestov, V. Petrov, M. Petrovici, R.P. Pezzi, S. Piano, M. Pikna, P. Pillot, O. Pinazza, L. Pinsky, C. Pinto, S. Pisano, M. Płoskoń, M. Planinic, F. Pliquett, M.G. Poghosyan, B. Polichtchouk, S. Politano, N. Poljak, A. Pop, S. Porteboeuf-Houssais, V. Pozdniakov, I.Y. Pozos, K.K. Pradhan, S.K. Prasad, S. Prasad, R. Preghenella, F. Prino, C.A. Pruneau, I. Pshenichnov, M. Puccio, S. Pucillo, Z. Pugelova, S. Qiu, L. Quaglia, S. Ragoni, A. Rai, A. Rakotozafindrabe, L. Ramello, F. Rami, T.A. Rancien, M. Rasa, S.S. Räsänen, R. Rath, M.P. Rauch, I. Ravasenga, K.F. Read, C. Reckziegel, A.R. Redelbach, K. Redlich, C.A. Reetz, H.D. Regules-Medel, A. Rehman, F. Reidt, H.A. Reme-Ness, Z. Rescakova, K. Reygers, A. Riabov, V. Riabov, R. Ricci, M. Richter, A.A. Riedel, W. Riegler, A.G. Riffero, C. Ristea, M.V. Rodriguez, M. Rodríguez Cahuantzi, S.A. Rodríguez Ramírez, K. Røed, R. Rogalev, E. Rogochaya, T.S. Rogoschinski, D. Rohr, D. Röhrich, P.F. Rojas, S. Rojas Torres, P.S. Rokita, G. Romanenko, F. Ronchetti, A. Rosano, E.D. Rosas, K. Roslon, A. Rossi, A. Roy, S. Roy, N. Rubini, D. Ruggiano, R. Rui, P.G. Russek, R. Russo, A. Rustamov, E. Ryabinkin, Y. Ryabov, A. Rybicki, H. Rytkonen, J. Ryu, W. Rzesa, O.A.M. Saarimaki, S. Sadhu, S. Sadovsky, J. Saetre, K. Šafařík, P. Saha, S.K. Saha, S. Saha, B. Sahoo, R. Sahoo, S. Sahoo, D. Sahu, P.K. Sahu, J. Saini, K. Sajdakova, S. Sakai, M.P. Salvan, S. Sambyal, D. Samitz, I. Sanna, T.B. Saramela, D. Sarkar, P. Sarma, V. Sarritzu, V.M. Sarti, M.H.P. Sas, S. Sawan, E. Scapparone, J. Schambach, H.S. Scheid, C. Schiaua, R. Schicker, F. Schlepper, A. Schmah, C. Schmidt, H.R. Schmidt, M.O. Schmidt, M. Schmidt, N.V. Schmidt, A.R. Schmier, R. Schotter, A. Schröter, J. Schukraft, K. Schweda, G. Scioli, E. Scomparin, J.E. Seger, Y. Sekiguchi, D. Sekihata, M. Selina, I. Selyuzhenkov, S. Senyukov, J.J. Seo, D. Serebryakov, L. Serkin, L. Šerkšnytė, A. Sevcenco, T.J. Shaba, A. Shabetai, R. Shahoyan, A. Shangaraev, B. Sharma, D. Sharma, H. Sharma, M. Sharma, S. Sharma, U. Sharma, A. Shatat, O. Sheibani, K. Shigaki, M. Shimomura, J. Shin, S. Shirinkin, Q. Shou, Y. Sibiriak, S. Siddhanta, T. Siemiarczuk, T.F. Silva, D. Silvermyr, T. Simantathammakul, R. Simeonov, B. Singh, K. Singh, R. Singh, S. Singh, V.K. Singh, V. Singhal, T. Sinha, B. Sitar, M. Sitta, T.B. Skaali, G. Skorodumovs, M. Slupecki, N. Smirnov, R.J.M. Snellings, E.H. Solheim, J. Song, C. Sonnabend, J.M. Sonneveld, F. Soramel, A.B. Soto-hernandez, R. Spijkers, I. Sputowska, J. Staa, J. Stachel, I. Stan, P.J. Steffanic, S.F. Stiefelmaier, D. Stocco, I. Storehaug, P. Stratmann, S. Strazzi, A. Sturniolo, C.P. Stylianidis, A.A.P. Suaide, C. Suire, M. Sukhanov, M. Suljic, R. Sultanov, V. Sumberia, S. Sumowidagdo, I. Szarka, M. Szymkowski, S.F. Taghavi, G. Taillepied, J. Takahashi, G.J. Tambave, S. Tang, Z. Tang, J.D. Tapia Takaki, N. Tapus, L.A. Tarasovicova, M.G. Tarzila, G.F. Tassielli, A. Tauro, A. Tavira García, G. Tejeda Muñoz, A. Telesca, L. Terlizzi, C. Terrevoli, S. Thakur, D. Thomas, A. Tikhonov, N. Tiltmann, A.R. Timmins, M. Tkacik, T. Tkacik, A. Toia, R. Tokumoto, K. Tomohiro, N. Topilskaya, M. Toppi, T. Tork, V.V. Torres, A.G. Torres Ramos, A. Trifiró, A.S. Triolo, S. Tripathy, T. Tripathy, S. Trogolo, V. Trubnikov, W.H. Trzaska, T.P. Trzcinski, A. Tumkin, R. Turrisi, T.S. Tveter, K. Ullaland, B. Ulukutlu, A. Uras, M. Urioni, G.L. Usai, M. Vala, N. Valle, L.V.R. van Doremalen, M. van Leeuwen, C.A. van Veen, R.J.G. van Weelden, P. Vande Vyvre, D. Varga, Z. Varga, P. Vargas Torres, M. Vasileiou, A. Vasiliev, O. Vázquez Doce, O. Vazquez Rueda, V. Vechernin, E. Vercellin, S. Vergara Limón, R. Verma, L. Vermunt, R. Vértesi, M. Verweij, L. Vickovic, Z. Vilakazi, O. Villalobos Baillie, A. Villani, A. Vinogradov, T. Virgili, M.M.O. Virta, V. Vislavicius, A. Vodopyanov, B. Volkel, M.A. Völkl, S.A. Voloshin, G. Volpe, B. von Haller, I. Vorobyev, N. Vozniuk, J. Vrláková, J. Wan, C. Wang, D. Wang, Y. Wang, A. Wegrzynek, F.T. Weiglhofer, S.C. Wenzel, J.P. Wessels, J. Wiechula, J. Wikne, G. Wilk, J. Wilkinson, G.A. Willems, B. Windelband, M. Winn, J.R. Wright, W. Wu, Y. Wu, Z. Xiong, R. Xu, A. Yadav, A.K. Yadav, S. Yalcin, Y. Yamaguchi, S. Yang, S. Yano, E.R. Yeats, Z. Yin, I.-K. Yoo, J.H. Yoon, H. Yu, S. Yuan, A. Yuncu, V. Zaccolo, C. Zampolli, F. Zanone, N. Zardoshti, A. Zarochentsev, P. Závada, N. Zaviyalov, M. Zhalov, B. Zhang, C. Zhang, L. Zhang, M. Zhang, S. Zhang, X. Zhang, Y. Zhang, Z. Zhang, M. Zhao, V. Zherebchevskii, Y. Zhi, C. Zhong, D. Zhou, Y. Zhou, J. Zhu, Y. Zhu, S.C. Zugravel, and N. Zurlo
Subjects: Physics, QC1-999
Abstract: In this letter, measurements of (anti)alpha production in central (0–10%) Pb–Pb collisions at a center-of-mass energy per nucleon–nucleon pair of sNN = 5.02 TeV are presented, including the first measurement of an antialpha transverse-momentum spectrum. Owing to its large mass, the production of (anti)alpha is expected to be sensitive to different particle production models. The production yields and transverse-momentum spectra of nuclei are of particular interest because they provide a stringent test of these models. The averaged antialpha and alpha spectrum is compared to the spectra of lighter particles, by including it into a common blast-wave fit capturing the hydrodynamic-like flow of all particles. This fit is indicating that the (anti)alpha also participates in the collective expansion of the medium created in the collision. A blast-wave fit including only protons, (anti)alpha, and other light nuclei results in a similar flow velocity as the fit that includes all particles. A similar flow velocity, but a significantly larger kinetic freeze-out temperature is obtained when only protons and light nuclei are included in the fit. The coalescence parameter B4 is well described by calculations from a statistical hadronization model but significantly underestimated by calculations assuming nucleus formation via coalescence of nucleons. Similarly, the (anti)alpha-to-proton ratio is well described by the statistical hadronization model. On the other hand, coalescence calculations including approaches with different implementations of the (anti)alpha substructure tend to underestimate the data.
Published: 2024
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36. Unitarity in the non-relativistic regime and implications for dark matter

Author: Marcos M. Flores and Kalliopi Petraki
Subjects: Unitarity, Resummation, Imaginary potential, Long-range interactions, Dark matter, Physics, QC1-999
Abstract: Unitarity sets upper limits on partial-wave elastic and inelastic cross-sections, which are often violated by perturbative computations. We discuss the dynamics underlying these limits in the non-relativistic regime, namely long-range interactions, and show how the resummation of the 2-particle-irreducible diagrams arising from squaring inelastic processes unitarizes both elastic and inelastic cross-sections. We provide a simple prescription to obtain the unitarized cross-sections from those that do not include resummation of the squared inelastic processes. Our results are model-independent, apply to all partial waves, and affect elastic and inelastic cross-sections, with extensive implications for new physics scenarios, such as dark-matter freeze-out, indirect detection and self-interactions.
Published: 2024
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37. Diagnóstico situacional del proceso enseñanza aprendizaje en posgrados de una unidad académica de Medicina. Una aproximación desde la percepción de docentes y profesionales estudiantes

Author: Sonia Arza Fernández, Jorge Ortiz, Miguel Franco, and Jorge Flores
Subjects: Competency formation, Postgraduate, Medical teaching, Pedagogical model, Education (General), L7-991, Medicine (General), R5-920
Abstract: Resumen: Introducción: el estudio tuvo como objetivo verificar el avance de implementación del modelo pedagógico orientado a competencias en posgrados de una facultad de Medicina, ya que la misma implementó una nueva malla curricular desde el año 2016, lográndose una primera cohorte de egresados, quienes buscarán consolidar su formación en subespecialidades que oferta la unidad académica. Métodos: estudio cualitativo con enfoque hermenéutico, interpretativo, con docentes y residentes de último año de posgrados seleccionados. Los datos fueron obtenidos mediante entrevistas semiestructuradas y grupos focales. Se analizaron los programas formativos. El modelo pedagógico orientado a competencias en posgrado fue la categoría principal que orientó los interrogantes, siendo analizadas las siguientes dimensiones: gestión académica, ejercicio docente, aprendizaje del profesional estudiante y estructura curricular. La recolección de datos concluyó una vez obtenida la saturación teórica. Resultados: analizando 22 entrevistas a docentes y grupos focales a 16 residentes de último año de posgrado, se identificó que el modelo pedagógico actualmente implementado, es mayoritariamente por contenidos, con innovaciones insuficientemente desarrolladas. Docentes con heterogénea formación e involucramiento en educación superior e implementación del nuevo modelo. Residentes de especialidades percibidos como espectadores, no involucrados en el proceso formativo que debió integrarse en posgrado para asegurar las competencias necesarias señaladas. Conclusión: en el ámbito de posgrado prevalece el modelo pedagógico por contenidos, sin que la orientación por competencias haya tenido continuidad, verificándose la necesidad de intervenciones en formación docente, involucramiento discente, mejoramiento de infraestructura y aseguramiento de la calidad educativa, para saturar los objetivos del plan estratégico institucional. Abstract: Introduction: The objective of the study was to verify the progress of implementation of the pedagogical model oriented to postgraduate competencies of a medical school, since it implemented a new curricular framework since 2016, achieving a first cohort of graduates, who will seek to consolidate their training in subspecialties offered by the academic unit. Methods: Qualitative study with a hermeneutic, interpretive approach with teachers and final year residents of selected postgraduate courses. The data were obtained through semi-structured interviews and focus groups. The training programs were analyzed. The pedagogical model oriented to postgraduate competencies was the main category that guided the questions, the following dimensions being analyzed: academic management, teaching practice, professional student learning and curricular structure. Data collection concluded once theoretical saturation was obtained. Results: Analyzing 22 interviews with teachers and focus groups with 16 final-year postgraduate residents, it was identified that the pedagogical model currently implemented is mostly content-based, with insufficiently developed innovations. Teachers with heterogeneous training and involvement in higher education and implementation of the new model. Residents of specialties perceived as spectators, not involved in the training process that should have been integrated into the postgraduate degree to ensure the necessary competencies indicated. Conclusion: In the postgraduate field, the pedagogical model by content prevails, without the orientation by competencies having had continuity, verifying the need for interventions in teacher training, student involvement, improvement of infrastructure and assurance of educational quality, to saturate the objectives of the plan institutional strategic.
Published: 2024
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38. Evidencias de validez de las preguntas de opción múltiple diseñadas por Microsoft Bing (Copilot)

Author: Javier A. Flores-Cohaila, Ramón Ruesta-Bermejo, Carlos Gutierrez-Rios, Carlos Ramos-Godoy, Brayan Miranda-Chávez, and Cesar Copaja-Corzo
Subjects: Medical education, Assessment, Artificial Intelligence, ChatGPT, Multiple-choice questions, Peru, Education (General), L7-991, Medicine (General), R5-920
Abstract: Resumen: Introducción: diseñar preguntas de opción múltiple (POM) con Microsoft Bing (Copilot) para evaluar su calidad e índices psicométricos en educación médica. Material y métodos: se diseñó un examen de 180 preguntas con Microsoft Bing. Este fue evaluado por educadores médicos en términos de relevancia y calidad de distractores. Luego, tras administrarse a estudiantes, se calcularon los índices de dificultad y discriminación. Resultados: la mayoría de preguntas fueron de alta relevancia y los distractores de alta calidad. Los índices de discriminación y dificultad de las preguntas fueron aceptables en la mayoría de preguntas. Conclusión: Microsoft Bing (Copilot) podría usarse como sustituto de ChatGPT para el diseño de POM dadas las evidencias de validez recolectadas en el estudio. Abstract: Introduction: To design multiple-choice questions (MCQs) using Microsoft Bing (Copilot) and evaluate their quality and psychometric indices in medical education. Materials and methods: A 180-question exam was designed using Microsoft Bing. It was evaluated by medical educators in terms of relevance and distractor quality. After administering the exam to students, difficulty and discrimination indices were calculated. Results: Most questions were highly relevant, and the distractors were of high quality. The discrimination and difficulty indices were acceptable for the majority of the questions. Conclusion: Microsoft Bing (Copilot) could be used as a substitute for ChatGPT in designing MCQs, given the evidence of validity collected in the study.
Published: 2024
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39. EP-139 - PERFIL EPIDEMIOLÓGICO DOS ACIDENTES ESCORPIÔNICOS NO ESTADO DE SÃO PAULO NO PERÍODO DE 2013 A 2022

Author: Julia Guerrero Teixeira de Freitas, Ananda Totti Rodrigues, and João Vitor Flores Coelho
Subjects: Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract: Introdução: O escorpionismo é um problema de saúde pública devido à elevada incidência em várias regiões do país. Em 2023, o Estado de São Paulo registrou um recorde histórico de ataques de escorpiões, com 49.381 casos, segundo a Secretaria Estadual de Saúde. Diante desse aumento e devido à carência de estudos sobre o assunto, a análise do perfil epidemiológico dos acidentes no Estado de São Paulo é de fundamental relevância, uma vez que constitui uma ferramenta importante para auxiliar políticas de saúde e subsidiar a adoção de medidas de prevenção eficazes, visando reduzir o número de acidentes. Objetivo: O objetivo deste estudo foi investigar as características epidemiológicas dos acidentes escorpiônicos no Estado de São Paulo entre 2013 e 2022, com atenção para a vulnerabilidade das crianças e o impacto desses acidentes em termos de mortalidade nesse grupo etário. Além disso, buscamos comparar os dados entre as distintas Regiões de Saúde do estado para identificar padrões e direcionar intervenções preventivas específicas. Método: O estudo analisou casos de acidentes por escorpiões em São Paulo de 2013 a 2022, usando dados do SINAN. Variáveis como sexo, idade, etnia, tempo de atendimento, gravidade e desfecho foram consideradas. A análise incluiu coeficientes de incidência, mortalidade e letalidade. Dados populacionais foram obtidos do IBGE. O estudo seguiu a Resolução n° 466/2012 do CNS e não precisou de aprovação ética. Resultados: As taxas mais altas de acidentes escorpiônicos foram em 2022 (372,6/100.000 habitantes), 2020 (321) e 2021 (296,52), com médias de incidência e mortalidade de 130,576 e 0,051/100.000 habitantes, e letalidade de 0,036%. O sexo masculino foi mais afetado (54,96%). A faixa etária de 5 a 9 anos representou 4,27% dos casos, e a de 10 a 14 anos, 5,10%. Os óbitos foram mais comuns em crianças de 1 a 9 anos de idade, totalizando 71 mortes. Conclusão: O estudo reflete o cenário nacional, com uma predominância de casos em adultos do sexo masculino. No entanto, é alarmante observar que as crianças, especialmente aquelas com 1 a 9 anos de idade, estão sujeitas a um maior risco de morte decorrente desses acidentes. Essa constatação ressalta a necessidade de estratégias direcionadas em reduzir o número de óbitos infantis. Como exemplo, inclusão de treinamentos quanto à clínica, capacitações dos profissionais de saúde e tratamento em tempo oportuno além de intensificar as ações de controle, visando à redução do número de escorpiões e a prevenção dos acidentes.
Published: 2024
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40. SÍNDROME MIELODISPLÁSICA COM DEL 20Q ISOLADA – RELATO DE CASO

Author: PEM Flores, JN Cavalcante, TAS Pereira, PM Yamamoto, LB Lanza, CB Prato, MCMA Macedo, and RL Silva
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introdução: As síndromes mielodisplásicas (SMD) são um grupo heterogêneo de doenças mieloides caracterizadas por hematopoiese clonal e insuficiência medular que causam citopenias periféricas, anormalidades citogenéticas recorrentes e um risco variável de progressão para leucemia mieloide aguda (LMA). Dada a heterogeneidade da doença e o comportamento clínico variável em termos de evolução para leucemia, muitas análises citogenéticas e molecular têm surgido como ferramentas para identificar pacientes com características biológicas, clínicas e prognósticas semelhantes. Nesse contexto, a alteração citogenética de del20q isolada denota um bom prognóstico, de acordo com a estratificação de risco vigente (IPSS-R e IPSS-M). Objetivo: Relatar um caso de SMD com del 20q isolada, em seguimento clínico há sete anos, sem progressão de doença. Relato de caso: Paciente masculino, 85 anos, evoluiu com bicitopenia – anemia leve com Hb 11,0 e plaquetopenia grave – 20.000, desde 2017. Na ocasião do diagnóstico, realizou estudo medular que mostrou displasia moderada nas três séries, associada a 20% de sideroblastos em anel e cariótipo com del 20q11.2 em 14 das 20 metáfases analisadas. Na ocasião, estratificado como risco baixo (IPSS-R: 2), no entanto, devido à plaquetopenia importante, optado por tratamento com hipometilante. Recebeu 3 ciclos de Azacitidina, com suspensão por sangramento com hemorragia subaracnóidea e infecções bacterianas graves de repetição. Desde então, manteve apenas seguimento clínico, sempre com plaquetopenia entre 20-30mil. Em Abril/24, quando teve piora da anemia – Hb 7,0, porém mantendo hemograma sem neutropenia e sem piora da plaquetopenia de base, optado por repetir estudo medular. Novo mielograma hipercelular, com displasia das três séries e 1,6% de blastos. Coloração para ferro mostrando 8% de sideroblastos em anel. Citogenética mantendo del 20q11.2 isolada em 19 das 20 metáfases analisadas. Não foi realizado estudo molecular por indisponibilidade pela operadora. Novo IPSS-R: 3 – baixo risco. Optado por iniciar tratamento com Alfapoetina 30.000 unidades semanais. Conclusão: Estudo retrospectivos demonstram que a entidade acima descrita é mais comum em homens, idosos, apresentando plaquetopenia como citopenia mais exuberante no diagnóstico e durante o acompanhamento. O caso do paciente acima vai de acordo ao encontrado na literatura disponível, e o tempo de seguimento do paciente está acima da média para a estratificação inicial, sem indícios atuais de evolução para LMA. Apesar de não termos estudo molecular disponível, a evolução do doente fala contra presença de mutação clonal de risco adicional em associação ao achado citogenético da del20q.
Published: 2024
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41. SIDEROBLASTOS EM ANEL APÓS TRATAMENTO DE LMA EM PACIENTE IDOSO COM PROTOCOLO VIALE- A: RELATO DE DOIS CASOS

Author: JN Cavalcante, PEM Flores, PM Yamamoto, LB Lanza, CB Prato, TAS Pereira, RL Silva, and MCMA Macedo
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introdução: A leucemia mieloide aguda (LMA) é a leucemia aguda mais comum, acometendo predominantemente um grupo de pessoas idosas, com uma idade mediana de 67 anos ao diagnóstico, sendo que esses pacientes frequentemente têm reposta insatisfatória ao tratamento quimioterápico convencional. A combinação de agente hipometilante com venetoclax, mostrou-se eficaz e segura neste cenário, sendo atualmente a terapia de escolha em pacientes maiores 60 anos e/ou com comorbidades limitantes. Efeitos adversos dessa terapia ainda estão sendo descobertos. Objetivo: Relatar dois casos de LMA em tratamento com o protocolo VIALE-A que tiveram surgimento de sidero blastos em anel ao curso do tratamento com Viale A. Relato de caso: Caso 1: LAB, sexo masculino, 63 anos, diagnóstico de LMA com TP53mutado, apresentava ao diagnóstico 60% de blastos à avaliação medular, foi submetido a tratamento com o protocolo VIALE-A e, após o 8° ciclo, foi observado medula óssea (MO)hipercelular, com displasia multilinhagem e presença de sidero blastos em anel (73%). Caso 2: AC, sexo masculino, 79 anos, LMA de risco intermediário, com displasia nas três séries analisadas e 18% de blastos no mielograma ao diagnóstico, após o 9° ciclo do protocolo VIALE-A, apresentava uma MO hipocelular, com displasia e presença desideroblastos em anel (59%) ao mielograma. Conclusão: Os pacientes relatados acima, alcançaram remissão morfológica com o protocolo de tratamento utilizado, evoluindo, após vários ciclos de tratamento, com displasia e presença de sidero blastos em anel. O caso 1 foi submetido a transplante de medula óssea após melhora do perfomance status e o segundo caso segue em tratamento com o protocolo VIALE-A. Relatos sobre o surgimento de tal displasia após tratamento nesse perfil de pacientes são escassos em literatura. É incerto se isso pode conferir fator prognóstico ou influenciar na resposta alcançada.
Published: 2024
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42. INFARTO RENAL SECUNDÁRIO A TROMBOSE ARTERIAL ‒ RELATO DE CASO

Author: ABV Nogueira, BE Campos, BP Foganholo, LG Yamashita, and PEM Flores
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Objetivos: Descrever um caso de infarto renal secundário a trombose em paciente previamente hígido sem fatores de risco. Material e métodos: Coleta de dados em prontuário e entrevistas com o paciente. Resultados: Homem, 48 anos, procurou pronto atendimento devido quadro de epigastralgia, edema de Membros Inferiores (MMII) e fraqueza, há 1 dia. Em uso diário de cúrcuma, vitamina K2MK7, semente de abóbora, BCAA, maca peruana, vitamina D e melatonina. Antecedente familiar de irmã com artrite reumatóide. Na avaliação clínica, apresentava dor à palpação de epigástrio e hipocôndrio direito, Descompressão Brusca (DB) negativa, edema +/4+ em MMII, bradicardia e hipertensão arterial. Houve melhora parcial da dor com sintomáticos e exames laboratoriais iniciais sem alterações. No dia seguinte, em consulta com cardiologista, apresentava discreto edema bipalpebral, DB positiva e bradicardia, então solicitado Eletrocardiograma (ECG) e Tomografia Computadorizada (TC) de abdome contrastado, que demonstraram, respectivamente, bradicardia sinusal e sinais de pielonefrite aguda à esquerda. Optado por internação, início de antibioticoterapia endovenosa e investigação cardiológica. Para elucidação diagnóstica de isquemia renal, foi solicitado angiotomografia arterial e venosa de abdome e pelve, a qual evidenciou possível área de infarto renal. Com provável diagnóstico, foi proposto iniciar anticoagulação com Enoxaparina 60 mg. Como paciente se mantinha estável hemodinamicamente, sem dor, exames laboratoriais sem alterações, foi preconizado anticoagulação domiciliar. Paciente mantinha-se em bradicardia sinusal pelo ECG, porém, assintomático, com incremento da frequência cardíaca ao conversar e resultado de ecocardiograma transtorácico sem anormalidades. Sem indicação de intervenção, paciente recebeu alta com anticoagulação plena (Rivaroxabana) e orientação para investigação ambulatorial de possíveis causas do evento. Exames para investigação de trombofilias não demonstraram evidência de distúrbios de coagulação. Discussão: As etiologias conhecidas de Oclusão Arterial Aguda (OAA) incluem os estados de hipercoagulabilidade, lesões arteriais, miocardiopatias, entre outras, que na investigação foram descartadas para o quadro clínico apresentado. A trombose de artéria renal sem evidências de fatores causais é uma ocorrência rara. Deve-se considerar, como diferencial, a suplementação de vitamina K2MK7 100 mcg/dia feita por 5 meses consecutivos, sem orientação médica, como agente causal da trombose, visto que a dosagem considerada segura é de 1 mcg/d/kg. Concordantemente com demais casos relatados de infarto renal, o paciente em questão apresentou elevação súbita da pressão arterial, explicada pela ativação do sistema renina-angiotensina-aldosterona na redução da perfusão renal. Além disso, foi observado alteração da função renal com os exames creatinina sérica de 1,17 mg/dL e eGFR 73 mL/min/1,73m2 e 24h após, creatinina sérica 1,28 mg/dL, eGFR 66 mL/min/1,73m2. Conclusão: A OAA é um desafio clínico aqui destacado, pela complexidade diagnóstica frente a uma condição incomum que pode se apresentar em pacientes sem fatores de risco evidentes, mas que requer reconhecimento precoce devido ao risco de insuficiência renal, de modo a considerá-lo como hipótese diferencial prezando pela eficácia do tratamento. Como apresentado, a ocorrência do quadro raro requer investigação adicional para elucidação causal.
Published: 2024
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43. ANTICOAGULAÇÃO EM PACIENTES INTERNADOS POR COVID-19: QUAL A ABORDAGEM IDEAL?

Author: LG Yamashita, AS Lima, ACM Arenghi, CT Buzo, FAA Paranaiba, GS Dias, GJ Ribeiro, LB Teodoro, RM Almeida, and PEM Flores
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Objetivos: A infecção por COVID-19 sabidamente gera um estado de hipercoagulabilidade que facilita eventos trombóticos. Até recentemente, havia poucas evidências sobre a melhor abordagem de anticoagulação - profilática ou terapêutica - para pacientes hospitalizados, tendo em vista mortalidade, eventos adversos, tempo de internação e custo-efetividade. Com esse objetivo, foi feita uma revisão da literatura sobre o tema. Material e método: Trata-se de uma revisão integrativa literária com abordagem qualitativa sob o tema proposto. Utilizou-se as bases de dados “Pubmed”, “Embase” e “The Cochrane Library” oriundo dos descritores “Anticoagulação”, “COVID-19”, “Hospitalização”e “Profilaxia”. Foram selecionados artigos publicados dos últimos 5 anos, resultando em 396 artigos em português e inglês, dos quais 17 foram escolhidos. Resultados e Discussão: A coagulopatia associada à COVID-19 está ligada a morbidade e mortalidade significativas. O SARS-CoV-2 afeta as células pulmonares através de enzimas conversoras de angiotensina (ECA), causando uma resposta inflamatória intensa e hipercoagulabilidade. As células imunológicas ativam o sistema complemento, comprometendo a coagulação e interrompendo a fibrinólise, o que favorece a formação de trombos. A doença pode cursar com disfunção orgânica, sendo que o estado de hipercoagulabilidade na sepse denominado coagulopatia induzida por sepse (SIC) antecede a coagulação intravascular disseminada (CIVD). Além disso, a doença progride com aumento gradativo dos níveis de D-dímero, elevando as taxas de mortalidade. O uso de anticoagulantes é fundamental na gestão da hipercoagulabilidade. Estudos sobre anticoagulação profilática em pacientes hospitalizados com COVID-19 indicam que a heparina profilática reduz a mortalidade significativamente; de acordo com um estudo coorte de destaque, a taxa corresponde a 27% nos primeiros 30 dias de internação sem amplificar o risco de sangramentos graves. Contudo, não há consenso quanto à dosagem. Metanálise e estudo coorte sugerem que a anticoagulação profilática é superior na eficácia e segurança em pacientes moderados a graves comparada à anticoagulação intermediária e terapêutica. No entanto, outros trabalhos apontam vantagem na abordagem terapêutica, nos desfechos de mortalidade e necessidade de internação, embora com maior risco de sangramentos. Segundo a Sociedade Internacional de Trombose e Hemostasia (ISTH), é sugerido que pacientes hospitalizados não gravemente enfermos selecionados recebam a dose terapêutica, enquanto pacientes mais graves recebam anticoagulação profilática. A discussão na literatura sobre a abordagem ideal é controversa, no quesito redução da mortalidade e eventos adversos, mas há consenso quanto à individualização do tratamento como base da tomada de decisão. Conclusão: O debate sobre o ideal esquema de anticoagulação continua, sendo necessária a individualização do tratamento conforme a gravidade e a história clínica do paciente, ponderando a opção mais prudente acerca do risco de sangramento e morbidade pelo uso de anticoagulante. Portanto, reafirma-se a atual recomendação da ISTH ao dar preferência a tromboprofilaxia em hospitalizados por Covid-19, reservando a dose terapêutica para casos individualizados, com fatores de risco adicionais.
Published: 2024
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44. Radiotherapy services in the Philippines: exploring geographical barriers to improve access to care

Author: Jerickson Abbie S. Flores, Charles Cedy C. Lo, John Michael P. Tomagan, Jaffar C. Pineda, Miriam Joy C. Calaguas, Enrico D. Tangco, Misael C. Cruz, Edward Christopher Dee, Jake John P. Galingana, Eleanore S. Altubar, and Jhonatan B. Riparip
Subjects: Public aspects of medicine, RA1-1270
Published: 2024
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45. Thermo-economic analysis of sun drying patio coffee in the Sierra Mariscal, Chiapas-México

Author: D. Santizo-Díaz and J.J. Flores-Prieto
Subjects: Coffee drying, Sun patio, Sun dying, Traditional coffee drying, Parchment coffee drying, Engineering (General). Civil engineering (General), TA1-2040
Abstract: This study shows a thermo-economic analysis of patio coffee drying in the Sierra Mariscal Chiapas-México to optimize bed thickness. The drying time, specific energy, thermal efficiency, water-effective diffusivity, and drying batch costs were correlated with bed thickness and solar irradiation. The initial and final coffee moisture contents were 53 % and 11–12 % (w.b). The bed thickness was in terms of kilograms of coffee uniformly spread on a square meter (2.0, 5.0, 10.0, 15.0, and 20.0 kg/m2). The five experimental campaigns involved five tests over a harvest season. The water-effective diffusion coefficient increases with bed thickness (0.38–91.2 × 10−10 m2/s). The solar irradiation requirement and the efficiency of the patio drying linearly increase with bed thickness while specific energy exponentially decreases. The lower specific energy was (7.1–10.4 MJ/kg) for the higher bed thickness (20.0 kg/m2), with (24.0–38.0 h) of drying time and (0.22–0.32) of efficiency. The optimized coffee bed thickness was 10 kg/m2, with a specific energy of 8.8–9.6 MJ/kg. When bed thickness increases, the thermal efficiency increases almost linearly 5.5 times, exponentially reducing the drying cost per batch five times. However, increasing drying times shall lessen the quality of physical-chemical and sensorial coffee.
Published: 2024
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46. Measurement of the production cross section of a Higgs boson with large transverse momentum in its decays to a pair of τ leptons in proton-proton collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M.A. Mahmoud, Y. Mohammed, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. Meena, G. Saha, M.A. Sessini, P. 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Della Negra, S. Fayer, G. Fedi, G. Hall, M.H. Hassanshahi, A. Howard, G. Iles, M. Knight, J. Langford, J. León Holgado, L. Lyons, A.-M. Magnan, S. Malik, A. Martelli, M. Mieskolainen, J. Nash, M. Pesaresi, B.C. Radburn-Smith, A. Richards, A. Rose, C. Seez, R. Shukla, A. Tapper, K. Uchida, G.P. Uttley, L.H. Vage, T. Virdee, M. Vojinovic, N. Wardle, D. Winterbottom, K. Coldham, J.E. Cole, A. Khan, P. Kyberd, I.D. Reid, S. Abdullin, A. Brinkerhoff, B. Caraway, J. Dittmann, K. Hatakeyama, J. Hiltbrand, B. McMaster, M. Saunders, S. Sawant, C. Sutantawibul, J. Wilson, R. Bartek, A. Dominguez, C. Huerta Escamilla, A.E. Simsek, R. Uniyal, A.M. Vargas Hernandez, B. Bam, R. Chudasama, S.I. Cooper, S.V. Gleyzer, C.U. Perez, P. Rumerio, E. Usai, R. Yi, A. Akpinar, A. Albert, D. Arcaro, C. Cosby, Z. Demiragli, C. Erice, C. Fangmeier, C. Fernandez Madrazo, E. Fontanesi, D. Gastler, F. Golf, S. Jeon, I. Reed, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, S. Yuan, A.G. Zecchinelli, G. Benelli, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J.M. Hogan, T. Kwon, G. Landsberg, K.T. Lau, D. Li, J. Luo, S. Mondal, M. Narain, N. Pervan, S. Sagir, F. Simpson, M. Stamenkovic, W.Y. Wong, X. Yan, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P.T. Cox, R. Erbacher, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, W. Wei, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, G. Flores Avila, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, A. Nunez Del Prado, D. Saltzberg, V. Valuev, R. Clare, J.W. Gary, M. Gordon, G. Hanson, W. Si, S. Wimpenny, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, A. Dorsett, J. Incandela, A.J. Li, P. Masterson, H. Mei, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, T.Á. Vámi, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J. Mao, H.B. Newman, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, M.B. Andrews, P. Bryant, M. Cremonesi, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, F. Marini, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, P. Kotamnives, J. Monroy, M. Oshiro, J.R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, A. Bethani, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, M. Dalchenko, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, I. Azhgirey, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, M. Chadeeva, V. Chekhovsky, R. Chistov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, R. Ryutin, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Volkov, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Higgs boson, Tau lepton, Physics, QC1-999
Abstract: A measurement of the production cross section of a Higgs boson with transverse momentum greater than 250GeV is presented where the Higgs boson decays to a pair of τ leptons. It is based on proton-proton collision data collected by the CMS experiment at the CERN LHC at a center-of-mass energy of 13TeV. The data sample corresponds to an integrated luminosity of 138fb−1. Because of the large transverse momentum of the Higgs boson the τ leptons from its decays are boosted and produced spatially close, with their decay products overlapping. Therefore, a dedicated algorithm was developed to reconstruct and identify them. The observed (expected) significance of the measured signal with respect to the standard model background-only hypothesis is 3.5 (2.2) standard deviations. The product of the production cross section and branching fraction is measured to be 1.64−0.54+0.68 times the standard model expectation. The fiducial differential production cross section is also measured as functions of the Higgs boson and leading jet transverse momenta. This measurement extends the probed large-transverse-momentum region in the ττ final state beyond 600GeV.
Published: 2024
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47. Hemp hull fiber and two constituent compounds, N-trans-caffeoyltyramine and N-trans-feruloyltyramine, shape the human gut microbiome in vitro

Author: Karla E. Flores Martinez, Clay S. Bloszies, Matthew J. Bolino, Bethany M. Henrick, and Steven A. Frese
Subjects: Microbiome, Gut microbiome, Prebiotic, Fiber, Hemp, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract: Mounting evidence supports the potential of dietary bioactives to reduce chronic disease risk. N-trans-caffeoyltyramine (NCT) and N-trans-feruloyltyramine (NFT) have been hypothesized to drive regulation of gut permeability, but these components have not yet been studied in the context of the human gut microbiome. This work examined whether purified NCT and NFT, or a hemp hull product containing NCT and NFT (Brightseed® Bio Gut Fiber™), can impact the gut microbiome using an in vitro fermentation assay. Representative human gut microbiomes were treated with Bio Gut Fiber™ or NCT and NFT and compared to starch and methylcellulose, as controls, in vitro. Stronger changes were exerted by Bio Gut Fiber™, NCT, and NFT. Communities treated with Bio Gut Fiber™ saw increased productivity and diversity. We found a dose-dependent effect of NCT and NFT on microbial communities. Here, we describe novel potential for hemp-derived bioactives to shape the gut microbiome.
Published: 2024
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48. Searches for violation of Lorentz invariance in top quark pair production using dilepton events in 13 TeV proton-proton collisions

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Clerbaux, A.K. Das, G. De Lentdecker, L. Favart, P. Gianneios, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, K. Mota Amarilo, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, C. Delaere, I.S. 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Meschi, V. Milosevic, F. Monti, F. Moortgat, M. Mulders, I. Neutelings, S. Orfanelli, F. Pantaleo, G. Petrucciani, A. Pfeiffer, M. Pierini, D. Piparo, H. Qu, D. Rabady, G. Reales Gutiérrez, M. Rovere, H. Sakulin, S. Scarfi, C. Schwick, M. Selvaggi, K. Shchelina, P. Silva, P. Sphicas, A.G. Stahl Leiton, A. Steen, S. Summers, D. Treille, P. Tropea, A. Tsirou, D. Walter, J. Wanczyk, S. Wuchterl, P. Zehetner, P. Zejdl, W.D. Zeuner, T. Bevilacqua, L. Caminada, A. Ebrahimi, W. Erdmann, R. Horisberger, Q. Ingram, H.C. Kaestli, D. Kotlinski, C. Lange, M. Missiroli, L. Noehte, T. Rohe, T.K. Aarrestad, K. Androsov, M. Backhaus, A. Calandri, C. Cazzaniga, K. Datta, A. De Cosa, G. Dissertori, M. Dittmar, M. Donegà, F. Eble, M. Galli, K. Gedia, F. Glessgen, C. Grab, D. Hits, W. Lustermann, A.-M. Lyon, R.A. Manzoni, M. Marchegiani, L. Marchese, C. Martin Perez, A. Mascellani, F. Nessi-Tedaldi, F. Pauss, V. Perovic, S. Pigazzini, C. Reissel, T. Reitenspiess, B. Ristic, F. Riti, D. Ruini, R. 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Komurcu, S. Sen, O. Aydilek, S. Cerci, V. Epshteyn, B. Hacisahinoglu, I. Hos, B. Kaynak, S. Ozkorucuklu, O. Potok, H. Sert, C. Simsek, C. Zorbilmez, B. Isildak, D. Sunar Cerci, A. Boyaryntsev, B. Grynyov, L. Levchuk, D. Anthony, J.J. Brooke, A. Bundock, F. Bury, E. Clement, D. Cussans, H. Flacher, M. Glowacki, J. Goldstein, H.F. Heath, L. Kreczko, S. Paramesvaran, S. Seif El Nasr-Storey, V.J. Smith, N. Stylianou, K. Walkingshaw Pass, R. White, A.H. Ball, K.W. Bell, A. Belyaev, C. Brew, R.M. Brown, D.J.A. Cockerill, C. Cooke, K.V. Ellis, K. Harder, S. Harper, M.-L. Holmberg, J. Linacre, K. Manolopoulos, D.M. Newbold, E. Olaiya, D. Petyt, T. Reis, G. Salvi, T. Schuh, C.H. Shepherd-Themistocleous, I.R. Tomalin, T. Williams, R. Bainbridge, P. Bloch, C.E. Brown, O. Buchmuller, V. Cacchio, C.A. Carrillo Montoya, G.S. Chahal, D. Colling, J.S. Dancu, I. Das, P. Dauncey, G. Davies, J. Davies, M. Della Negra, S. Fayer, G. Fedi, G. Hall, M.H. Hassanshahi, A. Howard, G. Iles, M. Knight, J. Langford, J. León Holgado, L. Lyons, A.-M. Magnan, S. Malik, M. Mieskolainen, J. Nash, M. Pesaresi, B.C. Radburn-Smith, A. Richards, A. Rose, K. Savva, C. Seez, R. Shukla, A. Tapper, K. Uchida, G.P. Uttley, L.H. Vage, T. Virdee, M. Vojinovic, N. Wardle, D. Winterbottom, K. Coldham, J.E. Cole, A. Khan, P. Kyberd, I.D. Reid, S. Abdullin, A. Brinkerhoff, B. Caraway, J. Dittmann, K. Hatakeyama, J. Hiltbrand, B. McMaster, M. Saunders, S. Sawant, C. Sutantawibul, J. Wilson, R. Bartek, A. Dominguez, C. Huerta Escamilla, A.E. Simsek, R. Uniyal, A.M. Vargas Hernandez, B. Bam, R. Chudasama, S.I. Cooper, S.V. Gleyzer, C.U. Perez, P. Rumerio, E. Usai, R. Yi, A. Akpinar, D. Arcaro, C. Cosby, Z. Demiragli, C. Erice, C. Fangmeier, C. Fernandez Madrazo, E. Fontanesi, D. Gastler, F. Golf, S. Jeon, I. Reed, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, S. Yuan, A.G. Zecchinelli, G. Benelli, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J.M. Hogan, T. Kwon, G. Landsberg, K.T. Lau, D. Li, J. Luo, S. Mondal, M. Narain, N. Pervan, S. Sagir, F. Simpson, M. Stamenkovic, W.Y. Wong, X. Yan, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P.T. Cox, R. Erbacher, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, W. Wei, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, G. Flores Avila, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, A. Nunez Del Prado, D. Saltzberg, V. Valuev, R. Clare, J.W. Gary, M. Gordon, G. Hanson, W. Si, S. Wimpenny, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, A. Dorsett, J. Incandela, A.J. Li, P. Masterson, H. Mei, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, T.Á. Vámi, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J. Mao, H.B. Newman, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, M.B. Andrews, P. Bryant, M. Cremonesi, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, P. Palit, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, P. Kotamnives, J. Monroy, M. Oshiro, J.R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, S. Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Top quark, Beyond standard model, Lorentz symmetry, Physics, QC1-999
Abstract: A search for violation of Lorentz invariance in the production of top quark pairs (tt‾) is presented. The measured normalized differential tt‾ production cross section, as a function of the sidereal time, is examined for potential modulations induced by Lorentz-invariance breaking operators in an effective field theory extension of the standard model (SM). The cross section is measured from collision events collected by the CMS detector at a center-of-mass-energy of 13 TeV, corresponding to an integrated luminosity of 77.8 fb−1, and containing one electron and one muon. The results are found to be compatible with zero, in agreement with the SM, and are used to place upper limits at 68% confidence level on the magnitude of the Lorentz-violating couplings ranging from 1–8×10−3. This is the first precision test of the isotropy in special relativity with top quarks at the LHC, restricting further the bounds on such couplings by up to two orders of magnitude with respect to previous searches conducted at the Tevatron.
Published: 2024
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49. Phenolic compounds from pumpkin pulp: Extraction optimization and biological properties

Author: Nicola Pinna, Salwa Ben Abbou, Federica Ianni, Giancarlo Angeles Flores, Anne Pietercelie, Giuseppe Perretti, Francesca Blasi, Paola Angelini, and Lina Cossignani
Subjects: Crop, Bioactives, Phenol extraction, HPLC-DAD analysis, Antioxidant activity, Functional foods, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract: Ultrasound-assisted extraction of (poly)phenols from pumpkin pulp was optimized using response surface methodology. Time, solvent-to-sample ratio and percentage of water in ethanol were considered and a full factorial design was applied. The optimized conditions (10 min; 30 mL/g; 50% water in ethanol) were used to isolate (poly)phenols from five pumpkin varieties (Hokkaido, Lunga di Napoli, Mantovana, Moscata di Provenza, Violina rugosa), collected for two successive years. Phenolic acids were the most abundant phenolic class (gallic acid up to 413.50 μg/g), even if differences were observed among varieties and harvesting years. Generally, Violina rugosa harvested in 2021 showed the highest total phenol content (7.59 mg gallic acid equivalents/g) and antioxidant properties (16.93 mg Trolox equivalents/g). All pumpkin variety exhibited antimicrobial activity within a concentration range of 1.95 to 250 μg/mL. In conclusion, the pumpkin pulp can be considered a promising natural source of (poly)phenols for the development of health-promoting products.
Published: 2024
Full Text: View/download PDF

50. Distributed software architecture for accessing the NFT-Vehicle

Author: Juan-Carlos López-Pimentel, Luis Alberto Morales-Rosales, Carolina Del-Valle-Soto, and José Alberto Del Puerto-Flores
Subjects: Blockchain, Vehicles, Smart contract, Tokenizing, Distributed architecture, Computer software, QA76.75-76.765
Abstract: Smart contracts have gained significant attention in the software development community because they are the mechanism for building blockchain applications. This work provides a distributed software architecture and an implementation for accessing a smart contract, called NFT-Vehicle, implemented on the Ethereum blockchain platform. The main idea behind NFT-Vehicle is the digitization process of a motorized vehicle in a digital asset. The architecture outlines two security protocols, one from the stakeholders who connect towards the back-end, and the other internally. The back-end includes mainly two parts: an API-gateway and the smart contract located in a blockchain. We report the acquired experiences and a list of identified errors found during the unit tests that are difficult to notice with simple requests. Our solution can be used as a base for real implementations of tokenizing physical cars into digital assets.
Published: 2024
Full Text: View/download PDF

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