Search

Your search keyword '"Fessler, R."' showing total 12 results
Start Over Author "Fessler, R." Publisher elsevier
12 results on '"Fessler, R."'

2. Contributors

Author

Abbed, Khalid M., primary, Abdullah, Kalil G., additional, Ackerman, Paul D., additional, Alapan, Yunus, additional, Alentado, Vincent J., additional, Alvin, Matthew D., additional, Ames, Christopher P., additional, Anand, Neel, additional, Anderson, Paul A., additional, Angelov, Lilyana, additional, Anissipour, Alireza K., additional, Anson, John A., additional, Apfelbaum, Ronald I., additional, Archdeacon, Michael, additional, Arnold, Paul M., additional, Arun, Mike W.J., additional, Arzi, Harel, additional, Awad, Ahmed J., additional, Awad, Basem I., additional, Bahuleyan, Biji, additional, Bain, Mark D., additional, Baird, Lissa C., additional, Baisden, Jamie, additional, Baldwin, Nevan G., additional, Ball, Perry A., additional, Balsara, Karl E., additional, Baron, Eli M., additional, Batjer, H. Hunt, additional, Bauer, Andrew M., additional, Bauer, Thomas W., additional, Beckman, Joshua M., additional, Bell, Gordon R., additional, Bellabarba, Carlo, additional, Bennett, E. Emily, additional, Benzel, Edward C., additional, Bergey, Darren L., additional, Bhalla, Tarun, additional, Bierbrauer, Karin S., additional, Bilsky, Mark, additional, Birk, Harjus, additional, Bisson, Erica F., additional, Bono, Christopher, additional, Bransford, Richard J., additional, Brodke, Darrel S., additional, Brooks, Nathaniel, additional, Brotea, Cristian, additional, Brougham, Jared R., additional, Browd, Samuel R., additional, Buckley, Robert T., additional, Burch, Shane, additional, Butler, John, additional, Bydon, Mohamad, additional, Casha, Steven, additional, Ceuppens, Jeroen, additional, Chan, Andrew K., additional, Chen, Thomas C., additional, Cheng, Joseph, additional, Chou, Dean, additional, Choudhri, Tanvir, additional, Clark, Aaron J., additional, Conley, Adam M., additional, Cooper, Paul R., additional, Coric, Domagoj, additional, Corriveau, Mark, additional, Côté, Ian P., additional, Coumans, Jean-Valery C.E., additional, Crawford, Charles H., additional, Curry, William T., additional, Daffner, Scott D., additional, Dalbayrak, Sedat, additional, DeMicco, Russell C., additional, Deutsch, Harel, additional, Dhall, Sanjay S., additional, DiAngelo, Denis J., additional, Dickman, Curtis A., additional, Dodwad, Shah-Nawaz M., additional, Duarte, Siena M., additional, Ebrahim, Zeyd, additional, Eckardt, Gerald W., additional, Ehni, Bruce L., additional, Eichholz, Kurt M., additional, Eichler, Marc, additional, Elbabaa, Samer K., additional, Elder, Benjamin D., additional, Elder, James B., additional, Ellenbogen, Richard G., additional, Epstein, Nancy, additional, Errico, Thomas J., additional, Esquenazi, Yoshua, additional, Fahim, Daniel K., additional, Farag, Ehab, additional, Farley, Chad W., additional, Fehlings, Michael G., additional, Feigenbaum, Frank, additional, Fenton, Eoin, additional, Ferrara, Lisa A., additional, Fessler, R. David, additional, Fessler, Richard G., additional, Finn, Michael A., additional, Finnan, Ryan, additional, Fischgrund, Jeffrey S., additional, Foley, Kevin T., additional, Fontes, Ricardo B.V., additional, Francis, Todd B., additional, Freedman, Brett A., additional, Frost, Frederick, additional, George, John, additional, German, John W., additional, Gerszten, Peter C., additional, Ghobrial, George M., additional, Ghogawala, Zoher, additional, Gibson, Justin L., additional, Gillis, Christopher C., additional, Goel, Vijay K., additional, Goffin, Jan, additional, Gokaslan, Ziya L., additional, Gollogly, Sohrab, additional, Goodwin, C. Rory, additional, Goulart, Carlos R., additional, Goz, Vadim, additional, Gozal, Yair M., additional, Graham, Randall B., additional, Grant, Gerald A., additional, Guan, Jian, additional, Gulec, Ilker, additional, Gussous, Yazeed M., additional, Guyer, Richard D., additional, Gwinn, David, additional, Ha, Sung, additional, Hadar, Eldad, additional, Haldeman, Clayton L., additional, Halim, Alexander Y., additional, Hamilton, Kimberly M., additional, Hammer, Christine L., additional, Hanbali, Fadi, additional, Hann, Shannon W., additional, Harms, Jurgen, additional, Harrop, James S., additional, Hart, Blaine L., additional, Hart, David J., additional, Harwell, Daniel, additional, Hayek, Reyaad A., additional, Heary, Robert F., additional, Henderson, Fraser C., additional, Hitchon, Patrick W., additional, Hoh, Daniel J., additional, Holman, Paul J., additional, Hosono, Noboru, additional, Houseman, Clifford, additional, Houten, John K., additional, Hsieh, Joseph C., additional, Hsu, Wellington K., additional, Huang, Meng, additional, Hurlbert, R. John, additional, Hwang, Lee, additional, Hwang, Steven, additional, İnceoğlu, Serkan, additional, Infinger, Libby Kosnik, additional, de Oliveira, Tatiana von Hertwig Fernandes, additional, Jalan, Devesh, additional, Jha, Neilank, additional, Johnson, J. Patrick, additional, Jones, Charles I., additional, Jones, G. Alexander, additional, Jones, Michael, additional, Juthani, Rupa G., additional, Kager, Christopher D., additional, Kalani, Maziyar A., additional, Kalani, M. Yashar S., additional, Kalfas, Iain H., additional, Kalra, Ricky R., additional, Karimi, Reza J., additional, Kashlan, Osama, additional, Kasliwal, Manish K., additional, Kaul, Vikas, additional, Kaushal, Mayank, additional, Kenning, Tyler J., additional, Khairi, Saad, additional, Khalaf, Tagreed, additional, Khalil, Jad G., additional, Khoo, Larry T., additional, Kiapour, Ali, additional, Kim, Daniel H., additional, Kim, David H., additional, Kimmell, Kristopher T., additional, Kirshblum, Steven, additional, Kitab, Sameer A., additional, Klimo, Paul, additional, Klineberg, Eric O., additional, Koski, Tyler R., additional, Kosztowski, Thomas A., additional, Kowalski, Robert J., additional, Krishnaney, Ajit A., additional, Krupa, Kelly, additional, Krupa, Kristin, additional, Kshettry, Varun R., additional, Kukreja, Sunil, additional, Kuntz, Charles, additional, Kurpad, Shekar N., additional, Kusuma, Srinivasu, additional, LaBagnara, Michael, additional, La Marca, Frank, additional, Laufer, Ilya, additional, Lavelle, Elizabeth Demers, additional, Lavelle, William F., additional, Lawrence, W. Thomas, additional, Lebl, Darren R., additional, Lee, Bryan S., additional, Lee, Sun-Ho, additional, Lenke, Lawrence G., additional, Leon, Steven P., additional, Li, Amy, additional, Li, Yiping, additional, Lieberman, Isador H., additional, Liu, James K.C., additional, Lo, Victor P., additional, Lollis, S. Scott, additional, Lopez-Gonzalez, Miguel, additional, Lubelski, Daniel, additional, Luciano, Mark G., additional, Machado, Andre G., additional, Maddela, Raghu, additional, Madineni, Ravichandra A., additional, Madura, Casey, additional, Maiman, Dennis J., additional, Malone, David G., additional, Mammis, Antonios, additional, Marawar, Satyajit, additional, Marcotte, Nicolas, additional, Maroon, Joseph C., additional, Martin, Michael D., additional, Martinez-del-Campo, Eduardo, additional, Massicotte, Eric M., additional, Mattei, Tobias A., additional, Maurer, Paul K., additional, Mayer, Eric A.K., additional, del Valle, Miguel Mayol, additional, Mazanec, Daniel J., additional, McCormick, Paul C., additional, McCormick, William, additional, Medress, Zachary A., additional, Mendel, Ehud, additional, Metkar, Umesh S., additional, Miele, Vincent J., additional, Mohyeldin, Ahmed, additional, Monsef, Jad Bou, additional, Moore, Timothy A., additional, Morisue, Hikaru, additional, Morone, Peter, additional, Mroz, Thomas E., additional, Mullin, Jeffrey P., additional, Murtagh, F. Reed, additional, Murtagh, Ryan D., additional, Naderi, Sait, additional, Nagaraj, Usha D., additional, Nalley, Charles C., additional, Nanda, Anil, additional, Nasca, Richard J., additional, Nater, Anick, additional, Neal, Matthew T., additional, Nockels, Russ P., additional, Norwig, John A., additional, Ondoma, Solomon M., additional, Oni-Orisan, Akinwunmi, additional, Oren, Jonathan H., additional, Orning, Jennifer, additional, Orr, R. Douglas, additional, Orrico, Katie, additional, Osorio, Joseph A., additional, Otero-Lopez, Ernesto, additional, O'Toole, John, additional, Park, Paul, additional, Parmar, Vikas, additional, Pashman, Robert S., additional, Patel, Rakesh D., additional, Patel, Smruti K., additional, Perez-Cruet, Mick J., additional, Perin, Noel I., additional, Pettigrew, David B., additional, Phillips, H. Westley, additional, Placide, Rick, additional, Porensky, Paul, additional, Prager, Joshua P., additional, Prasad, Srinivas, additional, Prasarn, Mark L., additional, Ramakrishnan, Rakesh, additional, Ramayya, Ashwin G., additional, Rampersaud, Y. Raja, additional, Rasmussen, Peter A., additional, Ratliff, John K., additional, Rauschning, Wolfgang, additional, Rechtine, Glenn R., additional, Recinos, Pablo F., additional, Resnick, Daniel K., additional, Rhee, Jay, additional, Rhines, Laurence D., additional, Riccio, Alexander R., additional, Richardson, Marlin Dustin, additional, Richter, Bertram, additional, Riesenburger, Ron, additional, Riew, K. Daniel, additional, Rogers, Matthew, additional, Saavedra, Fanor M., additional, Safain, Mina G., additional, Saigal, Rajiv, additional, Sawin, Paul D., additional, Scheer, Justin K., additional, Scheidler, Joshua, additional, Schippert, David W., additional, Schlenk, Richard, additional, Schmidt, Bradley, additional, Schmidt, Meic H., additional, Sciubba, Daniel M., additional, Shaffrey, Christopher I., additional, Shaffrey, Mark E., additional, Shah, Anoli, additional, Sharan, Alok, additional, Sharan, Ashwini D., additional, Shedid, Daniel, additional, Shook, Steven, additional, Silverstein, Michael P., additional, Simpson, Venita M., additional, Sin, Anthony, additional, Singh, Harminder, additional, Smith, Donald A., additional, Smith, Gabriel A., additional, Smith, Justin S., additional, Smith, Kyle A., additional, Sonntag, Volker K.H., additional, Soriano-Baron, Hector, additional, Spetzler, Robert F., additional, Spiker, W. Ryan, additional, Staub, Blake, additional, Steinmetz, Michael P., additional, Stillerman, Charles B., additional, Strayer, Andrea, additional, Subramaniam, Gandhivarma, additional, Sukkarieh, Hamdi G., additional, Sumich, Andrew, additional, Sun, Derrick Y., additional, Sunna, Tarek P., additional, Sure, Durga R., additional, Tallarico, Richard A., additional, Tan, Lee A., additional, Tatsui, Claudio E., additional, Techy, Fernando, additional, Theodore, Nicholas, additional, Theologis, Alexander A., additional, Thomas, Nicholas W.M., additional, Thorp, Brian D., additional, Tintle, Scott, additional, Tjoumakaris, Stavropoula, additional, Tobler, William D., additional, Togawa, Daisuke, additional, Traul, David, additional, Traynelis, Vincent C., additional, Tritle, A. Sophia, additional, Trost, Gregory R., additional, Tsai, Eve C., additional, Ugokwe, Kene, additional, Uluc, Kutlauy, additional, Uribe, Juan S., additional, Vaccaro, Alexander R., additional, Valadka, Alex, additional, Vedantam, Aditya, additional, Veeravagu, Anand, additional, Verma, Kushagra, additional, Vitaz, Todd, additional, Voyadzis, Jean-Marc, additional, Wagner, Scott, additional, Wahlquist, Trevor C., additional, Waldrop, Robert, additional, Walsh, Kevin M., additional, Wang, Jeffrey C., additional, Wang, Michael Y., additional, Wang, Patrick T., additional, Ward, John D., additional, Wardak, Zabi, additional, Wathen, Connor, additional, Weinstein, Philip R., additional, Weisman, Michael, additional, Welch, William C., additional, Weller, Simcha J., additional, Westerlund, L. Erik, additional, White, Jonathan A., additional, Whitmore, Robert G., additional, Wilberger, Jack E., additional, Williams, Kim A., additional, Winkler, Ethan A., additional, Witiw, Christopher D., additional, Wolfla, Christopher E., additional, Wolinsky, Jean-Paul, additional, Wong, Cyrus, additional, Woodard, Eric J., additional, Yanamadala, Vijay, additional, Yanni, Daniel S., additional, Yazbak, Philip A., additional, Yen, Chun-Po, additional, Yilmaz, Mesut, additional, Yoganandan, Narayan, additional, Yonemura, Kenneth S., additional, Yonenobu, Kazuo, additional, Yuan, Hansen A., additional, Yue, John K., additional, Zanation, Adam M., additional, Zavarella, Salvatore M., additional, Zeidman, Seth M., additional, Zileli, Mehmet, additional, Zuckerman, Scott, additional, and Zywicke, Holly, additional

Published
2017
Full Text
View/download PDF

4. Minimally Invasive Surgery for Mild-to-Moderate Adult Spinal Deformities: Impact on Intensive Care Unit and Hospital Stay.

Author

Chou D, Mundis G, Wang M, Fu KM, Shaffrey C, Okonkwo D, Kanter A, Eastlack R, Nguyen S, Deviren V, Uribe J, Fessler R, Nunley P, Anand N, Park P, and Mummaneni P

Subjects
Adult, Female, Humans, Male, Middle Aged, Prospective Studies, Retrospective Studies, Intensive Care Units trends, Length of Stay trends, Minimally Invasive Surgical Procedures methods, Minimally Invasive Surgical Procedures trends, Spinal Diseases diagnostic imaging, Spinal Diseases surgery
Abstract

Objective: To compare circumferential minimally invasive (cMIS) versus open surgeries for mild-to-moderate adult spinal deformity (ASD) with regard to intensive care unit (ICU) and hospital lengths of stay (LOS)., Methods: A retrospective review of 2 multicenter ASD databases with 426 ASD (sagittal vertical axis <6 cm) surgery patients with 4 or more fusion levels and 2-year follow-up was conducted. ICU stay, LOS, and estimated blood loss (EBL) were compared between open and cMIS surgeries., Results: Propensity matching resulted in 88 patients (44 cMIS, 44 open). cMIS were older (61 vs. 53 years, P = 0.005). Mean levels fused were 6.5 in cMIS and 7.1 in open (P = 0.368). Preoperative lordosis was higher in open than in cMIS (42.7° vs. 40.9°, P = 0.016), and preoperative visual analog score back pain was greater in open than in cMIS (7 vs. 6.2, P = 0.033). Preoperative and postoperative spinopelvic parameters and coronal Cobb angles were not different. EBL was 534 cc in cMIS and 1211 cc in open (P < 0.001). Transfusions were less in cMIS (27.3% vs. 70.5%, P < 0.001). ICU stay was 0.6 days for cMIS and 1.2 days for open (P = 0.009). Hospital LOS was 7.9 days for cMIS versus 9.6 for open (P = 0.804)., Conclusions: For patients with mild-to-moderate ASD, cMIS surgery had a significantly lower EBL and shorter ICU stay. Major and minor complication rates were lower in cMIS patients than open patients. Overall LOS was shorter in cMIS patients, but did not reach statistical significance., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Published
2019
Full Text
View/download PDF

5. Acquired Spinal Arteriovenous Fistula Presenting as Brown-Séquard Syndrome and Endovascular Treatment Outcome.

Author

Humaira R, To CY, Moudgil S, and Fessler R

Subjects
Angiography, Digital Subtraction, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Age of Onset, Brown-Sequard Syndrome diagnosis, Brown-Sequard Syndrome therapy, Central Nervous System Vascular Malformations diagnosis, Central Nervous System Vascular Malformations therapy, Embolization, Therapeutic methods, Pyramidal Tracts injuries, Spinal Cord blood supply, Spinal Cord Compression diagnosis, Spinal Cord Compression therapy, Spinal Cord Injuries complications, Wounds, Gunshot complications
Abstract

Background: Brown-Séquard syndrome is typically caused by penetrating trauma to the cervical spinal cord; however, other compressive and vascular occlusive etiologies have been previously described. It is extremely uncommon to have a delayed presentation as an extramedullary compressive lesion from the venous varix of an acquired spinal arteriovenous fistula., Case Description: We present a case of a patient in the fifth decade of life, with a remote history of gunshot wound to the left thorax with progressive left-sided weakness and contralateral pain and temperature sensory loss secondary to cord compression from an acquired spinal arteriovenous fistula., Conclusions: Subsequent treatment occurred with coil embolization with good outcome., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2016
Full Text
View/download PDF

6. Comparison of Complications and Clinical and Radiographic Outcomes Between Nonobese and Obese Patients with Adult Spinal Deformity Undergoing Minimally Invasive Surgery.

Author

Park P, Wang MY, Nguyen S, Mundis GM Jr, La Marca F, Uribe JS, Anand N, Okonkwo DO, Kanter AS, Fessler R, Eastlack RK, Chou D, Deviren V, Nunley PD, Shaffrey CI, and Mummaneni PV

Subjects
Adult, Aged, Back Pain etiology, Databases, Factual, Female, Humans, Incidence, Kyphosis diagnostic imaging, Kyphosis surgery, Lordosis diagnostic imaging, Lordosis surgery, Lumbar Vertebrae surgery, Male, Middle Aged, Minimally Invasive Surgical Procedures adverse effects, Musculoskeletal Abnormalities complications, Postoperative Complications etiology, Radiography, Reoperation, Retrospective Studies, Scoliosis diagnostic imaging, Scoliosis surgery, Spinal Fusion adverse effects, Spine pathology, Treatment Outcome, Body Mass Index, Musculoskeletal Abnormalities diagnostic imaging, Musculoskeletal Abnormalities surgery, Obesity complications, Spinal Fusion methods, Spine diagnostic imaging, Spine surgery
Abstract

Objective: Obesity can be associated with increased complications and potentially worse outcomes. We aimed to evaluate the impact of obesity on complications and outcomes in patients with adult spinal deformity (ASD) who underwent minimally invasive surgery (MIS)., Methods: A multicenter database of patients with ASD treated via MIS was queried. Of 190 patients in the database, 77 fit the inclusion criteria of 3 or more spinal levels treated minimally invasively. Patients were divided by body mass index (BMI) <30 (nonobese; n = 59) and BMI ≥ 30 (obese; n = 18)., Results: Mean BMI was 24.6 nonobese and 35.0 obese (P < 0.001). There were mean 3.8 interbody fusions nonobese and 4.7 obese (P = 0.065). Levels treated posteriorly averaged 5.8 nonobese and 5.9 obese (P = 0.502). Mean follow-up was 34.4 months nonobese and 35.3 months obese (P = 0.976). Baseline radiographic parameters were similar between groups. Postoperatively, SVA averaged 83.9 mm obese and 20.4 mm nonobese (P = 0.002). Postoperative lumbar lordosis-pelvic incidence mismatch averaged 17.9° obese and 9.9° nonobese (P = 0.028). Both groups had improvement in Oswestry Disability Index (ODI) scores with no difference in postoperative ODI scores between groups (P = 0.090). Similarly, both groups had decreased VAS scores for back and leg pain with no difference between groups postoperatively. Twenty (33.9%) nonobese patients versus 7 (38.9%) obese patients had complications (P = 0.452)., Conclusions: Our results suggest that obesity does not negatively impact complication rate or clinical outcomes in patients with ASD treated via MIS approaches., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2016
Full Text
View/download PDF

7. Can a Minimal Clinically Important Difference Be Achieved in Elderly Patients with Adult Spinal Deformity Who Undergo Minimally Invasive Spinal Surgery?

Author

Park P, Okonkwo DO, Nguyen S, Mundis GM Jr, Than KD, Deviren V, La Marca F, Fu KM, Wang MY, Uribe JS, Anand N, Fessler R, Nunley PD, Chou D, Kanter AS, Shaffrey CI, Akbarnia BA, Passias PG, Eastlack RK, and Mummaneni PV

Subjects
Age Factors, Aged, Back Pain diagnosis, Back Pain etiology, Back Pain prevention & control, Cohort Studies, Databases, Factual, Female, Humans, Male, Radiography, Recovery of Function, Spinal Curvatures complications, Spinal Curvatures diagnostic imaging, Treatment Outcome, Lumbar Vertebrae, Minimally Invasive Surgical Procedures, Sacrum, Spinal Curvatures surgery, Spinal Fusion
Abstract

Background: Older age has been considered a relative contraindication to complex spinal procedures. Minimally invasive surgery (MIS) techniques to treat patients with adult spinal deformity (ASD) have emerged with the potential benefit of decreased approach-related morbidity., Objective: To determine whether a minimal clinically important difference (MCID) could be achieved in patients ages ≥ 65 years with ASD who underwent MIS., Methods: Multicenter database of patients who underwent MIS for ASD was queried. Outcome metrics assessed were Oswestry Disability Index (ODI) and visual analog scale (VAS) scores for back and leg pain. On the basis of published reports, MCID was defined as a positive change of 12.8 ODI, 1.2 VAS back pain, and 1.6 VAS leg pain., Results: Forty-two patients were identified. Mean age was 70.3 years; 31 (73.8%) were women. Preoperatively, mean coronal curve, pelvic tilt, pelvic incidence to lumbar lordosis mismatch, and sagittal vertical axis were 35°, 24.6°, 14.2°, and 4.7 cm, respectively. Postoperatively, mean coronal curve, pelvic tilt, pelvic incidence to lumbar lordosis, and sagittal vertical axis were 18°, 25.4°, 11.9°, and 4.9 cm, respectively. A mean of 5.0 levels was treated posteriorly, and a mean of 4.0 interbody fusions was performed. Mean ODI improved from 47.1 to 25.1. Mean VAS back and leg pain scores improved from 6.8 and 5.9 to 2.7 and 2.7, respectively. Mean follow-up was 32.1 months. For ODI, 64.3% of patients achieved MCID. For VAS back and leg pain, 82.9% and 72.2%, respectively, reached MCID., Conclusions: MCID represents the threshold at which patients feel a meaningful clinical improvement has occurred. Our study results suggest that the majority of elderly patients with modest ASD can achieve MCID with MIS., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2016
Full Text
View/download PDF

9. The effect of mescaline, 3, 4-dimethoxyphenethylamine and 2, 5-dimethoxy-4-methylamphetamine on rat plasma prolactin: evidence for serotonergic mediation.

Author

Meltzer HY, Fessler RG, Simonovic M, and Fang VS

Subjects
Animals, Fenclonine pharmacology, Male, Methyltyrosines pharmacology, Methysergide pharmacology, Rats, Time Factors, DOM 2,5-Dimethoxy-4-Methylamphetamine pharmacology, Amphetamines pharmacology, Dimethoxyphenylethylamine pharmacology, Mescaline pharmacology, Phenethylamines pharmacology, Prolactin blood, Serotonin physiology
Published
1978
Full Text
View/download PDF

10. Effects of phencyclidine and methylphenidate on d-amphetamine-induced behaviors in reserpine pretreated rats.

Author

Fessler RG, Sturgeon RD, and Meltzer HY

Subjects
Animals, Ataxia chemically induced, Dose-Response Relationship, Drug, Drug Synergism, Humans, Male, Rats, Dextroamphetamine pharmacology, Methylphenidate pharmacology, Motor Activity drug effects, Phencyclidine pharmacology, Reserpine pharmacology, Stereotyped Behavior drug effects
Abstract

The effects and interactions of phencyclidine (PCP), methylphenidate and d-amphetamine on locomotor activity, stereotyped behavior and ataxia in reserpine- and vehicle-pretreated rats were examined. The behaviors of rats receiving PCP alone or in combination with other drugs were quantified along three dimensions (locomotor activity, stereotyped behavior, and ataxia) on scales developed in this laboratory. The behaviors of groups receiving methylphenidate and/or d-amphetamine in treatment combinations other than those including PCP were quantified using a well known d-amphetamine behavioral rating scale. PCP, methylphenidate and d-amphetamine each induced significant increases in locomotor activity and stereotyped behavior when administered alone. Reserpine was found to antagonize PCP-induced locomotor activity and stereotyped behavior, and methylphenidate-induced stereotyped behavior at a dose which either potentiated or had no significant effect upon d-amphetamine-induced behavior (depending upon the scale used). Reserpine also potentiated PCP-induced ataxia. Whereas PCP potentiated the locomotor activity induced by d-amphetamine in both reserpine- and vehicle-pretreated subjects, methylphenidate marginally antagonized d-amphetamine-induced stereotypy in reserpine-pretreated subjects. PCP-induced ataxia in reserpine pretreated subjects appeared moderately reduced in subjects also receiving d-amphetamine. In general, the behavioral effects of PCP appear to be more similar to those of methylphenidate than to those of d-amphetamine, but differences are also found between PCP and methylphenidate. The results are discussed in relation to a behavioral model recently proposed as a method for differentiating indirect dopamine agonists on the basis of their neurochemical mechanisms of action.

Published
1980
Full Text
View/download PDF

11. Incidental finding of double minutes (DM), single minutes (SM), homogenously staining regions (HSR), premature chromosome condensation (PCC), and premature centromere division (PCD)?

Author

Bühler EM, Fessler R, Beutler C, and Gargano G

Subjects
Adult, Cells, Cultured, Female, Humans, Infant, Newborn, Karyotyping, Lymphocytes cytology, Male, Middle Aged, Mitosis, Pregnancy, Centromere ultrastructure, Chromosome Aberrations, Chromosome Disorders, Chromosomes ultrastructure, Diseases in Twins, Klinefelter Syndrome genetics, Twins, Twins, Dizygotic
Abstract

The incidental finding of DM's, minutes, HSR's, PCC, and PCD in two completely unrelated cases--one is a prenatal diagnosis in a twin pregnancy complicated by hydramnios and feto-fetal exsanguination, the other is an adult Klinefelter patient--raises the question whether such findings are coincidental or whether there is a common denominator in such cases. Possible relationships between these phenomena and the observed cases are discussed.

Published
1987

12. Phencyclidine-induced ipsilateral rotation in rats with unilateral 6-hydroxydopamine-induced lesions of the substantia nigra.

Author

Fessler RG, Sturgeon RD, and Meltzer HY

Subjects
Animals, Apomorphine pharmacology, Dextroamphetamine pharmacology, Dose-Response Relationship, Drug, Humans, Male, Methyltyrosines pharmacology, Rats, Time Factors, Behavior drug effects, Hydroxydopamines pharmacology, Phencyclidine pharmacology, Stereotyped Behavior drug effects, Substantia Nigra drug effects
Published
1979
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results