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1. [Comparative statistical study of two antiemetics, metoclopramide and metopimazine, effects on the oestrus cycle in the female rat (author's transl)].

Author

Jadot G, Bruguerolle B, Bouyard L, Fabregou-Bergier P, and Bouyard P

Subjects
Animals, Antiemetics administration & dosage, Diestrus drug effects, Female, Isonipecotic Acids administration & dosage, Metoclopramide administration & dosage, Phenothiazines administration & dosage, Pregnancy, Rats, Statistics as Topic, Time Factors, Vaginal Smears, Antiemetics pharmacology, Estrus drug effects, Isonipecotic Acids pharmacology, Metoclopramide pharmacology, Phenothiazines pharmacology
Abstract

A comparative study of two antiemetic neuroleptics, metoclopramide and metopimazine, effects on the oestrus cycle of female rats has been done. These compounds were administered once daily for 21 consecutive days (1, 0,1, 0,01, 0,001 mg/kg/s.c.) on Wistar AFSPF rats, exhibiting regular four day cycles. Evolution of oestrus cycle was studied by daily vaginal smears. Our data show that metoclopramide does not influence oestrus cycle, while metopimazine suppress oestrus cycles, substituted for a permanent dioestrus. For the last compound, a statistically significant difference between treated and controls is demonstrated.

Published
1980

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