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2 results on '"Eun-Yi, Ko"'

1. Anti-inflammatory activities of the products of supercritical fluid extraction from Litsea japonica fruit in RAW 264.7 cells

Author

Sang-Mok Song, Young-Min Ham, Yoeng-Jong Ko, Eun-Yi Ko, Dae-Ju Oh, Chang-Sook Kim, Daekyung Kim, Kil-Nam Kim, and Weon-Jong Yoon

Subjects
Supercritical fluid extraction, Litsea japonica, Anti-inflammatory activity, Nuclear factor-κB, Mitogen-activated protein kinase, Nutrition. Foods and food supply, TX341-641
Abstract

The anti-inflammatory activities of the products of supercritical fluid extraction of Litsea japonica fruit (SFELJF) using supercritical carbon dioxide were investigated. The SFELJF extract dose-dependently inhibited the production of inflammatory markers [nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2)] and proinflammatory cytokines [tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6] induced by lipopolysaccharide (LPS) treatment. To further elucidate the mechanisms underlying these inhibitory effects, LPS-induced nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinase (MAPK) phosphorylation were studied. The SFELJF extract inhibited NF-κB (p65 and p50) activation and MAPK [extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38] phosphorylation in a dose-dependent manner. These results suggest that the anti-inflammatory activities of SFELJF extracts are due to proinflammatory cytokines and mediators via suppression of NF-κB activation and MAPK phosphorylation.

Published
2016
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2. Anti-inflammatory activities of the products of supercritical fluid extraction from Litsea japonica fruit in RAW 264.7 cells

Author

Kil-Nam Kim, Eun-Yi Ko, Dae-Ju Oh, Young-Min Ham, Daekyung Kim, Chang-Sook Kim, Yoeng-Jong Ko, Weon-Jong Yoon, and Sang-Mok Song

Subjects
0301 basic medicine, MAPK/ERK pathway, p38 mitogen-activated protein kinases, Medicine (miscellaneous), Pharmacology, Supercritical fluid extraction, Proinflammatory cytokine, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, Anti-inflammatory activity, TX341-641, Protein kinase A, Nutrition and Dietetics, biology, Chemistry, Kinase, Nutrition. Foods and food supply, Mitogen-activated protein kinase, Nuclear factor-κB, Nitric oxide synthase, 030104 developmental biology, Biochemistry, Litsea japonica, biology.protein, Food Science
Abstract

The anti-inflammatory activities of the products of supercritical fluid extraction of Litsea japonica fruit (SFELJF) using supercritical carbon dioxide were investigated. The SFELJF extract dose-dependently inhibited the production of inflammatory markers [nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2)] and proinflammatory cytokines [tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6] induced by lipopolysaccharide (LPS) treatment. To further elucidate the mechanisms underlying these inhibitory effects, LPS-induced nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinase (MAPK) phosphorylation were studied. The SFELJF extract inhibited NF-κB (p65 and p50) activation and MAPK [extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38] phosphorylation in a dose-dependent manner. These results suggest that the anti-inflammatory activities of SFELJF extracts are due to proinflammatory cytokines and mediators via suppression of NF-κB activation and MAPK phosphorylation.

Published
2016

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