1. Sustained release of arsenic trioxide benefits interventional therapy on rabbit VX2 liver tumor.
- Author
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Fu X, Luo RG, Qiu W, Ouyang L, Fan GQ, Liang QR, and Tang Q
- Subjects
- Animals, Delayed-Action Preparations pharmacokinetics, Delayed-Action Preparations pharmacology, Ethiodized Oil chemistry, Ethiodized Oil pharmacokinetics, Ethiodized Oil pharmacology, Liver Neoplasms, Experimental metabolism, Liver Neoplasms, Experimental pathology, Rabbits, Arsenic Trioxide pharmacokinetics, Arsenic Trioxide pharmacology, Chemoembolization, Therapeutic, Liver Neoplasms, Experimental therapy, Prodrugs pharmacokinetics, Prodrugs pharmacology
- Abstract
The benefit of chemotherapy as a constituent of transcatheter arterial chemoembolization (TACE) is still in debate. Recently we have developed arsenic trioxide nanoparticle prodrug (ATONP) as a new anticancer drug, but its systemic toxicity is a big issue. In this preclinical TACE study, ATONP emulsified in lipiodol behaved as drug-eluting bead manner. Sustained release of arsenic from ATONP within occluded tumor caused very low arsenic level in plasma, avoiding the "rushing out" effect as ATO did. Correspondingly, intratumoral arsenic accumulation and inorganic phosphate deprivation were simultaneously observed, and arsenic concentration was much higher as ATONP was transarterially administered than ATO, or intravenously injected. Tumor necrosis and apoptosis were remarkably more severe in ATONP group than ATO, but no significant hepatic and renal toxicity was perceived. In brief, ATONP alleviated arsenic toxicity and boosted the therapeutic effect of TACE via Pi-activated drug sustainable release., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2020
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