1. Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia.
- Author
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Cheon EJ, Male AG, Gao B, Adhikari BM, Edmond JT, Hare SM, Belger A, Potkin SG, Bustillo JR, Mathalon DH, Ford JM, Lim KO, Mueller BA, Preda A, O'Leary D, Strauss GP, Ahmed AO, Thompson PM, Jahanshad N, Kochunov P, Calhoun VD, Turner JA, and van Erp TGM
- Subjects
- Humans, Anhedonia, Brain diagnostic imaging, Mood Disorders, Motivation, Schizophrenia diagnostic imaging
- Abstract
This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia., Competing Interests: Declaration of Competing Interest Dr. Daniel H. Mathalon consulted for Neurocrine Biosciences, Gilgamesh Pharmaceuticals, and Recognify Life Sciences, and served on a data safety monitoring/advisory board for Neurocrine Biosciences. The other authors have no conflict of interest to report., (Copyright © 2023. Published by Elsevier B.V.)
- Published
- 2023
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