1. Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles.
- Author
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Eddahmi M, La Spada G, Hafid A, Khouili M, Catto M, and Bouissane L
- Subjects
- Amyloidogenic Proteins, Brain, Cholinesterases, Monoamine Oxidase, Copper chemistry, Catalysis, Alzheimer Disease drug therapy, Indazoles chemical synthesis, Triazoles chemical synthesis
- Abstract
In this work, we have investigated the one pot strategy for the Cu(I)-mediated synthesis of new triazoles bearing nitroindazole moieties using different copper catalysts. The biological activity of newly synthesized nitroindazolyltriazoles towards Alzheimer's disease-related targets, namely cholinesterases, monoamine oxidases, and amyloid aggregation, were investigated. Predictions of target affinity, physicochemical parameters, gastrointestinal absorption and brain penetration were achieved by means of in silico tools., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
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