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Your search keyword '"EVOLA, Giovanna"' showing total 2 results
Start Over Author "EVOLA, Giovanna" Publisher elsevier
2 results on '"EVOLA, Giovanna"'

1. Impact of insulin resistance on cardiac and vascular function.

Author

Novo G, Manno G, Russo R, Buccheri D, Dell'Oglio S, Morreale P, Evola G, Vitale G, and Novo S

Subjects
Aged, Cardiovascular Diseases diagnosis, Carotid Arteries diagnostic imaging, Coronary Angiography methods, Echocardiography methods, Female, Humans, Italy epidemiology, Male, Middle Aged, Risk Assessment methods, Risk Factors, Ultrasonography, Doppler methods, Vascular Stiffness physiology, Cardiovascular Diseases epidemiology, Insulin Resistance physiology
Abstract

Background: Insulin resistance (IR), constitutes an important cardiovascular risk factor and can cause ischemic heart disease. It can lead to left ventricular dysfunction with a mechanism independent of ischemic heart disease and it is closely associated with impaired vascular function. The aim of our study was to explore the impact of IR on cardiac and vascular function, in patients with cardiovascular risk factors but angiographically undamaged coronary arteries., Methods: We studied 32 patients (62.06±11.19years) with cardiovascular risk factors. All patients underwent coronary angiography, echocardiography, Doppler ultrasound of carotid arteries and laboratory tests. Exclusion criteria were coronary artery disease detected by coronary angiography, diabetes mellitus, creatinine above 1.5mg/dl, atrial fibrillation or malignant arrhythmias, left-ventricular hypertrophy, valvular heart disease, ejection fraction below 50%. The presence of insulin resistance was assessed using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Each patient underwent a complete echocardiographic examination including Global Longitudinal Strain assessment and carotid artery ultrasound scan including measurement of arterial stiffness., Results: The patients were divided into two groups based on the median value of HOMA-IR, the first group for values <4.14 and, the second, for values ≥4.14. Ejection fraction and diastolic function did not significantly differ between the two groups, whether in patients with higher levels of HOMA-IR (≥4.14) we observed a Global Longitudinal Strain (GLS) that was significantly reduced (-16.50±1.37% vs. -20.73±1.84%, p=0.0015) vascular stiffness, measured in the carotid arteries as pulse wave velocity (PWV) (9.70±1.75m/s vs. 7.40±1.89m/s, p=0.00148) that was increased. At multivariate analysis HOMA-IR was an independent predictor of myocardial dysfunction (GLS: coefficient 0.1156, p<0.0001)., Conclusion: Insulin resistance is associated with subclinical myocardial and vascular alterations in patients without significant coronary artery disease, measured as a reduction of Global Longitudinal Strain, and increased arterial stiffness. Our results underscore the importance of studying the interaction between ventricular function and vessels, in the perspective of more effective preventive and therapeutic interventions., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Published
2016
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2. Chronic pharmacological treatment in takotsubo cardiomyopathy.

Author

Fazio G, Pizzuto C, Barbaro G, Sutera L, Incalcaterra E, Evola G, Azzarelli S, Palecek T, Di Gesaro G, Cascio C, Novo G, Akashi YJ, and Novo S

Subjects
Adrenergic beta-Antagonists therapeutic use, Aged, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Aspirin therapeutic use, Calcium Channel Blockers therapeutic use, Female, Humans, Male, Retrospective Studies, Treatment Outcome, Takotsubo Cardiomyopathy drug therapy
Abstract

Background: Takotsubo cardiomyopathy is a disorder that has been appreciated only recently. In most of reported cases, this syndrome mimes an acute myocardial infarction. Till this moment no data are available from literature about the treatment in the acute phase of this disease., Aim of the Study: In our multicentric experience we have retrospectively looked at the benefits of a treatment with ACE-inhibitors, beta-blockers, Aspirin and calcium channels blockers, started until the early phases of the disease and continued for 30 days, in 36 patients affected by Takotsubo cardiomyopathy. We chose as endpoint of the study the efficacy of the used drug in improving left ventricular myocardial function and the rapidity of the effects of the same drug.bethods: from an international registry about the Takotsubo cardiomiopathy, co-ordinate by our research group, we evaluated the long term efficacy of some drugs, administrated like single treatment in some patients., Results: Obtained data did not show any statistically significant difference in the percentages of improvement in the left ventricle ejection fraction evaluated at the admission to the hospital, before the discharge and after 30 days of treatment between each treated group and the control group of non-treated patients. No significant differences were found in hospitalization times between treated patients and controls. None of our patients experienced during the observation period a relapse of the disease., Conclusions: The results of our survey suggest that a chronic treatment with beta-blockers, ACE-inhibitors, calcium channels blockers and aspirin does not provide any benefit in patients with Takotsubo cardiomyopathy. Thus, it seem to be important an early correct differential diagnosis to avoid any chronic treatment in these patients.

Published
2008
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