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1. Influence of PMMA on radiation dose of tissues in therapeutical radiation plans

Author: M.A. Diez Ulloa, C. Otero Martinez, M.A. Tubio Abuin, D. FariÑAs Torres, E. Diez Sanchidrian, D. Santin Mon, H. Dominguez Barreiro, H. Castro Villamor, M. Neira Boga, J. Pino Minguez, R.J. Chavez Reyes, N. Vazquez Agra, E. Gonzalez KÖLmel, and L. Puente Sanchez
Subjects: Neurology. Diseases of the nervous system, RC346-429
Published: 2024
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2. Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement

Author: N.J.B. Brereton, F.E. Pitre, and E. Gonzalez
Subjects: Microbiome, Mars, Space science, Astronaut health, 16S rRNA gene, Biotechnology, TP248.13-248.65
Abstract: Maintaining astronaut health throughout long-duration spaceflight is essential to the feasibility of a manned mission to Mars. The ground-based Mars500 experiment investigated long-duration health by isolating six astronauts for 520 days, the longest controlled human confinement study conducted to date. After 520 days, astronauts had uniform strength and lean body mass losses, and increased fasting plasma glucose, calprotectin, and neutrophil levels characteristic of intestinal inflammation but previous analyses revealed no common significant changes in gut microbiota. This study reanalysed data from early (days 7–45) and late (days 420–520) faecal samples and identified 408 exact sequence variants (ESVs), including 213 shared by all astronauts. Thirty-two ESVs were significantly differentially abundant over time, including depletion of keystone resistant starch degrading, anti-inflammatory and insulin sensitivity-associated species, such as Faecalibacterium prausnitzii, Ruminococcus bromii, Blautia luti, Anaerostipes hadrus, Roseburia faecis, and Lactobacillus rogosae, and enrichment of yet-to-be-cultured bacteria. Additionally, the extraordinary experimental confinement allowed observation of microbiota potentially shared between astronauts and their habitat. Forty-nine species were shared, representing 49% and 12% of the human and environmental microbiome diversity, respectively. These findings reveal the microbiota which significantly altered in relative abundance throughout confinement, including species known to influence inflammation and host glucose homeostasis consistent with astronaut symptoms. Identification of microbiome alterations after 520 days of isolation represents a missing piece connecting Mars500 astronaut physiological studies. Knowledge of the impact of long-term confinement upon the human microbiome helps to improve our understanding of how humans interact with their habitats and is a valuable step forward towards enabling long-duration spaceflight.
Published: 2021
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3. P-66 COULD PROTEIN CONTENT OF URINARY EXTRACELLULAR VESICLES BE USEFUL TO DETECT CIRRHOSIS IN ALCOHOLIC LIVER DISEASE?

Author: E. Gonzalez, M. Azkargorta, C. Garcia-Vallicrosa, J. Prieto-Elordui, F. Elortza, S. Blanco-Sampascual, and J.M. Falcon-Perez
Subjects: Specialties of internal medicine, RC581-951
Abstract: Introduction: Alcohol abuse has a high impact on the mortality and morbidity related to a great number of diseases and is responsible for the development of alcoholic liver disease (ALD). It remains challenging to detect and evaluate its severity, which is crucial for prognosis. Objective: In this work, we studied if urinary EVs (uEVs) could serve in diagnose and evaluate cirrhosis in ALD. Methods: uEVs characterization by cryo-electron microscopy (Cryo-EM), Nanoparticle Tracking Analysis (NTA) and Western blotting (WB) was performed in a cohort of 21 controls and 21 cirrhotic patients. Then, proteomics of urinary EVs (uEVs) was carried out in a second cohort of 6 controls and 8 patients in order to identify new putative biomarkers for cirrhosis in ALD. Results: uEVs concentration, size and composition were altered in cirrhotic patients. A total of 1304 proteins were identified in uEVs, and 90 of them were found to be altered in cirrhotic patients. Conclusions: uEVs could be considered as a tool and a supplier of new biomarkers for ALD, whose application would be especially relevant in chronic patients. Yet, further research is necessary to obtain more relevant result in clinical terms.
Published: 2021
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4. ADPedKD: A Global Online Platform on the Management of Children With ADPKD

Author: Stéphanie De Rechter, Detlef Bockenhauer, Lisa M. Guay-Woodford, Isaac Liu, Andrew J. Mallett, Neveen A. Soliman, Lucimary C. Sylvestre, Franz Schaefer, Max C. Liebau, Djalila Mekahli, P. Adamczyk, N. Akinci, H. Alpay, C. Ardelean, N. Ayasreh, Z. Aydin, A. Bael, V. Baudouin, U.S. Bayrakci, A. Bensman, H. Bialkevich, A. Biebuyck, O. Boyer, O. Bjanid, A. Bryłka, S. Çalışkan, A. Cambier, A. Camelio, V. Carbone, M. Charbit, B. Chiodini, A. Chirita, N. Çiçek, R. Cerkauskiene, L. Collard, M. Conceiçao, I. Constantinescu, A. Couderc, B. Crapella, M. Cvetkovic, B. Dima, F. Diomeda, M. Docx, N. Dolan, C. Dossier, D. Drozdz, J. Drube, O. Dunand, P. Dusan, L.A. Eid, F. Emma, M. Espino Hernandez, M. Fila, M. Furlano, M. Gafencu, M.S. Ghuysen, M. Giani, M. Giordano, I. Girisgen, N. Godefroid, A. Godron-Dubrasquet, I. Gojkovic, E. Gonzalez, I. Gökçe, J.W. Groothoff, S. Guarino, A. Guffens, P. Hansen, J. Harambat, S. Haumann, G. He, L. Heidet, R. Helmy, F. Hemery, N. Hooman, B. llanas, A. Jankauskiene, P. Janssens, S. Karamaria, I. Kazyra, J. Koenig, S. Krid, P. Krug, V. Kwon, A. La Manna, V. Leroy, M. Litwin, J. Lombet, G. Longo, A.C. Lungu, A. Mallawaarachchi, A. Marin, P. Marzuillo, L. Massella, A. Mastrangelo, H. McCarthy, M. Miklaszewska, A. Moczulska, G. Montini, A. Morawiec-Knysak, D. Morin, L. Murer, I. Negru, F. Nobili, L. Obrycki, H. Otoukesh, S. Özcan, L. Pape, S. Papizh, P. Parvex, M. Pawlak-Bratkowska, L. Prikhodina, A. Prytula, C. Quinlan, A. Raes, B. Ranchin, N. Ranguelov, R. Repeckiene, C. Ronit, R. Salomon, R. Santagelo, S.K. Saygılı, S. Schaefer, M. Schreuder, T. Schurmans, T. Seeman, N. Segers, M. Sinha, E. Snauwaert, B. Spasojevic, S. Stabouli, C. Stoica, R. Stroescu, E. Szczepanik, M. Szczepańska, K. Taranta-Janusz, A. Teixeira, J. Thumfart, M. Tkaczyk, R. Torra, D. Torres, N. Tram, B. Utsch, J. Vande Walle, R. Vieux, R. Vitkevic, A. Wilhelm-Bals, E. Wühl, Z.Y. Yildirim, S. Yüksel, and K. Zachwieja
Subjects: Diseases of the genitourinary system. Urology, RC870-923
Abstract: Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of renal failure. For several decades, ADPKD was regarded as an adult-onset disease. In the past decade, it has become more widely appreciated that the disease course begins in childhood. However, evidence-based guidelines on how to manage and approach children diagnosed with or at risk of ADPKD are lacking. Also, scoring systems to stratify patients into risk categories have been established only for adults. Overall, there are insufficient data on the clinical course during childhood. We therefore initiated the global ADPedKD project to establish a large international pediatric ADPKD cohort for deep characterization. Methods: Global ADPedKD is an international multicenter observational study focusing on childhood-diagnosed ADPKD. This collaborative project is based on interoperable Web-based databases, comprising 7 regional and independent but uniformly organized chapters, namely Africa, Asia, Australia, Europe, North America, South America, and the United Kingdom. In the database, a detailed basic data questionnaire, including genetics, is used in combination with data entry from follow-up visits, to provide both retrospective and prospective longitudinal data on clinical, radiologic, and laboratory findings, as well as therapeutic interventions. Discussion: The global ADPedKD initiative aims to characterize in detail the most extensive international pediatric ADPKD cohort reported to date, providing evidence for the development of unified diagnostic, follow-up, and treatment recommendations regarding modifiable disease factors. Moreover, this registry will serve as a platform for the development of clinical and/or biochemical markers predicting the risk of early and progressive disease. Keywords: ADPKD, ADPedKD Registry, children, longitudinal
Published: 2019
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5. NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice

Author: M. Herranz-Itúrbide, J. López-Luque, E. Gonzalez-Sanchez, D. Caballero-Díaz, E. Crosas-Molist, B. Martín-Mur, M. Gut, A. Esteve-Codina, V. Jaquet, J.X. Jiang, N.J. Török, and I. Fabregat
Subjects: NADPH oxidase, NOX4, Liver regeneration, Hepatectomy, MYC, TGF-BETA, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass. The NADPH oxidase NOX4 mediates Transforming Growth Factor-beta (TGF-β) actions, including apoptosis in hepatocytes and activation of stellate cells to myofibroblasts. Aim of this work was to analyze the impact of NOX4 in liver regeneration by using two mouse models where Nox4 was deleted: 1) general deletion of Nox4 (NOX4−/−) and 2) hepatocyte-specific deletion of Nox4 (NOX4hepKO). Liver regeneration was analyzed after 2/3 partial hepatectomy (PH). Results indicated an earlier recovery of the liver-to-body weight ratio in both NOX4−/− and NOX4hepKO mice and an increased survival, when compared to corresponding WT mice. The regenerative hepatocellular fat accumulation and the parenchyma organization recovered faster in NOX4 deleted livers. Hepatocyte proliferation, analyzed by Ki67 and phospho-Histone3 immunohistochemistry, was accelerated and increased in NOX4 deleted mice, coincident with an earlier and increased Myc expression. Primary hepatocytes isolated from NOX4 deleted mice showed higher proliferative capacity and increased expression of Myc and different cyclins in response to serum. Transcriptomic analysis through RNA-seq revealed significant changes after PH in NOX4−/− mice and support a relevant role for Myc in a node of regulation of proliferation-related genes. Interestingly, RNA-seq also revealed changes in the expression of genes related to activation of the TGF-β pathway. In fact, levels of active TGF-β1, phosphorylation of Smads and levels of its target p21 were lower at 24 h in NOX4 deleted mice. Nox4 did not appear to be essential for the termination of liver regeneration in vivo, neither for the in vitro hepatocyte response to TGF-β1 in terms of growth inhibition, which suggest its potential as therapeutic target to improve liver regeneration, without adverse effects.
Published: 2021
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6. Radium 223 in metastatic castration resistant prostate prostate. Effectiveness in clinical practice

Author: M.C. Salas Buzón, R. Rodríguez Sánchez, S. Sayago Gil, E. Gonzalez Calvo, and C. Muñoz Higueras
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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7. Venous thromboembolic events stratified by number of risk factors in patients with metastatic germ cell tumours undergoing first-line chemotherapy

Author: C. Fankhauser, B. Tran, J.M. Ruiz-Morales, E. Gonzalez-Billalabeitia, A. Patrikidou, E. Amir, C. Seidel, C. Bokemeyer, T. Hermanns, A. Tryakin, A. Rumyantsev, M. Brito, A. Flechon, E.M. Kwan, T. Cheng, D. Castellano, X. Garcia Del Muro, A.A. Hamid, M. Ottaviano, R. Kitson, A. Reid, D.Y.C. Heng, P.L. Bedard, C.J. Sweeney, and J.M. Connors
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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8. Increased body condition score through increased lean muscle, but not fat deposition, is associated with reduced reproductive response to oestrus induction in beef cows

Author: A. Guzmán, E. Gonzalez-Padilla, P. Garcés-Yepez, J.V. Rosete-Fernández, R.C. Calderón-Robles, W.D. Whittier, D.H. Keisler, and C.G. Gutierrez
Subjects: β-AA, energy status, IGF-I, insulin, leptin, Animal culture, SF1-1100
Abstract: Energy reserve, estimated as body condition score (BCS), is the major determinant of the re-initiation of ovarian activity in postpartum cows. Leptin, IGF-I and insulin are positively related to BCS and are putative mediators between BCS and reproductive function. However, when BCS and body composition dissociates, concentrations of these metabolic hormones are altered. We hypothesized that increasing lean muscle tissue, but not fat tissue, would diminish the reproductive response to oestrus induction treatments. Thirty lactating beef cows with BCS of 3.10±1.21 and 75.94±12 days postpartum were divided in two groups. Control cows (n=15) were supplemented with 10.20 kg of concentrate daily for 60 days. Treated cows (n=15) were supplemented equally, and received a β-adrenergic receptor agonist (β-AA; 0.15 mg/kg BW) to achieve accretion of lean tissue mass and not fat tissue mass. Twelve days after ending concentrate supplementation/β-AA treatment, cows received a progestin implant to induce oestrus. Cows displaying oestrus were inseminated during the following 60 days, and maintained with a fertile bull for a further 21 days. Cows in both groups gained weight during the supplementation period (Daily weight gain: Control=0.75 kg v. β-AA=0.89 kg). Cows treated with β-AA had a larger increase in BCS (i.e. change in BCS: control=1 point (score 4.13) v. β-AA=2 points (score 5.06; P0.05) did not differ between groups. However, the number of cows displaying oestrus (control 13/15 v. β-AA 8/15; P
Published: 2016
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9. Survival analysis of the surgical treatment of hepatocellular carcinoma at a tertiary care center

Author: C. Magadan Álvarez, J.M. Olmos-Martínez, E. González Tolaretxipi, A. Lozano Najera, E. Toledo Martínez, and J.C. Rodríguez Sanjuan
Subjects: Carcinoma hepatocelular, Supervivencia, Carga tumoral, Trasplante hepático, Resección hepática, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Introduction and aims: Hepatocellular carcinoma (HCC) is a primary malignant tumor of liver epithelial cells and is the most frequent primary liver cancer. The broadening of transplantation and resectability criteria has made therapeutic decisions more complex. Our aim was to describe the clinical and survival characteristics of patients with HCC treated through resection or liver transplantation at our hospital and identify the presence of factors that enable outcome prediction and facilitate therapeutic decision-making. Materials and methods: Patients with HCC that underwent surgery with curative intent at the Hospital Universitario Marqués de Valdecilla, within the time frame of 2007 and 2017, were retrospectively identified. Survival, mortality, disease-free interval, and different outcome-related variables were analyzed. Results: Ninety-six patients with a mean follow-up after surgery of 44 months were included. Overall mortality and recurrence were higher in the resection group. Mean survival was 51.4 months in the liver transplantation group and 37.5 months in the resection group, and the disease-free interval was 49.4 ± 37.2 and 27.4 ± 28.7 months, respectively (p = 0.002). The tumor burden score was statistically significant regarding risk for recurrence and specific mortality. Conclusions: There appears to be no patient subgroup in whom the results of surgical resection were superior or comparable to those of transplantation. Tumor burden determination could be a useful tool for patient subclassification and help guide therapeutic decision-making. Resumen: Introducción y objetivos: El carcinoma hepatocelular (CHC) es una neoplasia maligna primaria de células epiteliales hepáticas que constituye la neoplasia primaria hepática más frecuente. La ampliación de criterios de trasplante y resecabilidad han hecho más complejas las decisiones terapéuticas. Nos proponemos describir las características clínicas y supervivencia de los pacientes con CHC tratados mediante resección (RH) o trasplante hepático (THO) en nuestro Hospital, e identificar la presencia de factores que permitan predecir el pronóstico y facilitar las decisiones terapéuticas. Material y métodos: Se identificaron retrospectivamente los pacientes con CHC intervenidos con intención curativa en el Hospital Universitario Marqués de Valdecilla entre 2007 y 2017. Se analizaron la supervivencia, mortalidad, intervalo libre de enfermedad, así como distintas variables relacionadas con el pronóstico. Resultados: Se registraron 96 pacientes con un seguimiento medio tras cirugía de 44 meses. La mortalidad global y la recidiva fueron superiores en el grupo de resección. La supervivencia media fue de 51.4 meses en el grupo de TOH y de 37.5 meses en el de resección y el tiempo libre de enfermedad alcanzó los 49.4 ± 37.2 y 27.4 ± 28.7 meses, respectivamente (p: 0.002). La carga tumoral, valorada a través del “tumor burden score”, presentó una relación significativa con el riesgo de recidiva y la mortalidad específica. Conclusiones: No parece existir un subgrupo de pacientes en los que la resección quirúrgica presente resultados de supervivencia superiores o equiparables al trasplante. La carga tumoral podría ser una herramienta útil para subclasificar y ayudar a guiar las decisiones terapéuticas.
Published: 2024
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10. Análisis de supervivencia del tratamiento quirúrgico del carcinoma hepatocelular en un centro de tercer nivel

Author: C. Magadan Álvarez, J.M. Olmos-Martínez, E. González Tolaretxipi, A. Lozano Najera, E. Toledo Martínez, and J.C. Rodríguez Sanjuan
Subjects: Hepatocellular carcinoma, Survival, Tumor burden, Liver transplantation, Liver resection, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Resumen: Introducción y objetivos: El carcinoma hepatocelular (CHC) es una neoplasia maligna primaria de células epiteliales hepáticas que constituye la neoplasia primaria hepática más frecuente. La ampliación de criterios de trasplante y resecabilidad han hecho más complejas las decisiones terapéuticas. Nos proponemos describir las características clínicas y la supervivencia de los pacientes con CHC tratados mediante resección hepática (RH) o trasplante hepático ortotópico (THO) en nuestro hospital, e identificar la presencia de factores que permitan predecir el pronóstico y facilitar las decisiones terapéuticas. Material y métodos: Se identificaron retrospectivamente los pacientes con CHC intervenidos con intención curativa en el Hospital Universitario Marqués de Valdecilla entre 2007 y 2017. Se analizaron la supervivencia, la mortalidad, el intervalo libre de enfermedad, así como distintas variables relacionadas con el pronóstico. Resultados: Se registraron 96 pacientes con un seguimiento medio tras cirugía de 44 meses. La mortalidad global y la recidiva fueron superiores en el grupo de resección. La supervivencia media fue de 51.4 meses en el grupo de TOH y de 37.5 meses en el de RH, y el tiempo libre de enfermedad alcanzó los 49.4 ± 37.2 y 27.4 ± 28.7 meses, respectivamente (p: 0.002). La carga tumoral, valorada a través del «tumor burden score», presentó una relación significativa con el riesgo de recidiva y la mortalidad específica. Conclusiones: No parece existir un subgrupo de pacientes en los que la resección quirúrgica presente resultados de supervivencia superiores o equiparables al trasplante. La carga tumoral podría ser una herramienta útil para subclasificar y ayudar a guiar las decisiones terapéuticas. Abstract: Introduction and aims: Hepatocellular carcinoma (HCC) is a primary malignant tumor of liver epithelial cells and is the most frequent primary liver cancer. The broadening of transplantation and resectability criteria has made therapeutic decisions more complex. Our aim was to describe the clinical and survival characteristics of patients with HCC treated through resection or liver transplantation at our hospital and identify the presence of factors that enable outcome prediction and facilitate therapeutic decision-making. Materials and methods: Patients with HCC that underwent surgery with curative intent at the Hospital Universitario Marqués de Valdecilla, within the time frame of 2007 and 2017, were retrospectively identified. Survival, mortality, disease-free interval, and different outcome-related variables were analyzed. Results: Ninety-six patients with a mean follow-up after surgery of 44 months were included. Overall mortality and recurrence were higher in the resection group. Mean survival was 51.4 months in the liver transplantation group and 37.5 months in the resection group, and the disease-free interval was 49.4 ± 37.2 and 27.4 ± 28.7 months, respectively (p = 0.002). The tumor burden score was statistically significant regarding risk for recurrence and specific mortality. Conclusions: There appears to be no patient subgroup in whom the results of surgical resection were superior or comparable to those of transplantation. Tumor burden determination could be a useful tool for patient subclassification and help guide therapeutic decision-making.
Published: 2024
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11. Review: Exploring the use of precision livestock farming for small ruminant welfare management

Author: C. Morgan-Davies, G. Tesnière, J.M. Gautier, G.H.M. Jørgensen, E. González-García, S.I. Patsios, E.N. Sossidou, T.W.J. Keady, B. McClearn, F. Kenyon, G. Caja, L. Grøva, M. Decandia, L. Cziszter, I. Halachmi, and C.M. Dwyer
Subjects: Goats, Sheep, Stakeholders, Technologies, Welfare indicators, Animal culture, SF1-1100
Abstract: Small ruminant (sheep and goat) production of meat and milk is undertaken in diverse topographical and climatic environments and the systems range from extensive to intensive. This could lead to different types of welfare compromise, which need to be managed. Implementing Precision Livestock Farming (PLF) and other new or innovative technologies could help to manage or monitor animal welfare. This paper explores such opportunities, seeking to identify promising aspects of PLF that may allow improved management of welfare for small ruminants using literature search (two reviews), workshops in nine countries (France, Greece, Ireland, Israel, Italy, Norway, Romania, Spain, and the United Kingdom) with 254 stakeholders, and panels with 52 experts. An investigation of the main welfare challenges that may affect sheep and goats across the different management systems in Europe was undertaken, followed by a prioritisation of animal welfare issues obtained in the nine countries. This suggested that disease and health issues, feed access and undernutrition/malnutrition, maternal behaviour/offspring losses, environmental stressors and issues with agonistic behavioural interactions were important welfare concerns. These welfare issues and their indicators (37 for sheep, 25 for goats) were categorised into four broad welfare indicator categories: weight loss or change in body state (BWC), behavioural change (BC), milk yield and quality (MY), and environmental indicators (Evt). In parallel, 24 potential PLF and innovative technologies (8 for BWC; 10 for BC; 4 for MY; 6 for Evt) that could be relevant to monitor these broad welfare indicator categories and provide novel approaches to manage and monitor welfare have been identified. Some technologies had the capacity to monitor more than one broad indicator. Out of the 24 technologies, only 12 were animal-based sensors, or that could monitor the animal individually. One alternative could be to incorporate a risk management approach to welfare, using aspects of environmental stress. This could provide an early warning system for the potential risks of animal welfare compromise and alert farmers to the need to implement mitigation actions.
Published: 2024
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12. Observation and modeling of Hurricane Maria for damage assessment

Author: Juan Pablo Montoya Rincon, Rabindra Pokhrel, Salvador del Cos, Jorge E. Gonzalez, and Equisha Glenn
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Geography, Planning and Development, WRF, 0207 environmental engineering, Hurricane Maria, 02 engineering and technology, Precipitation, Damage assessment, Management, Monitoring, Policy and Law, 01 natural sciences, Wind speed, Observation and modelling, Wind shear, Meteorology. Climatology, 020701 environmental engineering, 0105 earth and related environmental sciences, Orographic lift, Orographic effect, Anomaly (natural sciences), Flooding (psychology), Storm, Sea surface temperature, Climatology, Weather Research and Forecasting Model, Environmental science, QC851-999
Abstract: The human loss due to Hurricane Maria (H-Maria) in the month of September of 2017 was quantified to be more than 4500 casualties in the entire island of Puerto Rico, making it the most devastating storm in US history. Besides, H-Maria left a lasting impact on the Island as it brought to full collapse the electrical power grid rendering the Island entirely out of power for more than ten months. The aim of this work is to fill the gap of the hydro-meteorological processes of this relevant storm due to the limited observational data available. The synoptic observational record shows that the monthly average Sea Surface Temperature of 30 °C, with an anomaly of 0.5 °C as well as low vertical wind shear of 4–8 m/s fueled H-Maria. Simulated (WRF) time series of wind speed is in close resemblance compared with the limited data available from ocean buoys with a simulated and observed peak wind speed of 30 m/s on the southern coast of the Island. The total rainfall for the event was simulated to peak at 762 mm (observed 965 mm) at the center of the Island and was validated with post-hurricane National Weather Service (NWS) rainfall with a Normalized Root Mean Square Error (RMSE) of 0.2. The orographic effects are simulated, reflecting enhancement of the rainfall at high altitudes in the central mountains of the Island. As an example of damage assessment, the risk of failure of the electrical power towers as a function of wind speed and soil saturation is simulated using statistical models for the entire Island, which results in higher risks of failure at the Northwest and center of the Island. These validated results of the storm can also be used as an input for other analysis such as hydrological models to geo-locate regions for risks due to flooding.
Published: 2021

13. Posttransplantation diabetes mellitus after liver transplant and the impact of family history of diabetes in a Mexican cohort

Author: A. Fernández-Ramírez, A. Olivas-Martinez, J. Ruiz-Manriquez, E. Kauffman-Ortega, C. Moctezuma-Velázquez, E. Marquez-Guillen, A.G. Contreras, M. Vilatobá, E. González-Flores, R. Cruz-Martínez, N.C. Flores-García, and I. García-Juárez
Subjects: Trasplante hepático, DMPT, Diabetes, Antecedente familiar, Mexicanos, NODAT, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Introduction and aims: Posttransplantation diabetes mellitus (PTDM) is a serious long-term complication that has a negative impact on graft and patient survival. The purpose of the present study was to describe the incidence of PTDM in a Mexican cohort and evaluate its association with a previous family history of diabetes (FHD). Methods: A retrospective single-center cohort study was conducted on patients undergoing liver transplantation (LT). The primary outcome was time from LT to PTDM. The diagnosis of PTDM was established using the ADA criteria. A mediation analysis that used adjusted Cox regression models and considered pretransplant prediabetes a mediator was performed, to determine the total effect and direct effect of FHD on PTDM. Results: A total of 152 patients were included, with a median follow-up time of 41 months; 19.2% (n = 29) had pretransplant diabetes. During the follow-up time, 15% of patients developed PTDM (n = 23), with an incidence rate of 4.71 cases/100 person-years. PTDM was significantly higher in patients with FHD, compared with those with no FHD (8.72 cases/100 person-years vs 2.04 cases/100 person-years, respectively; p = 0.001). The adjusted hazard ratio of PTDM for FHD was 4.14 (95% CI 1.60–10.7), p = 0.005) and 3.48 (95% CI 1.35–9.01, p = 0.010), when further controlled for pretransplant prediabetes. Conclusion: The occurrence of PTDM was similar to that reported in most international studies. As with type 2 diabetes, family history plays an important role in the development of PTDM, even after accounting for pretransplant prediabetes. Patients with FHD should undergo a stricter metabolic program. Resumen: Introducción y objetivos: La diabetes mellitus posterior a trasplante (DMPT) es una complicación grave de largo plazo que tiene un impacto negativo sobre el injerto y la sobrevida del paciente. El objetivo del presente estudio fue describir la incidencia de la DMPT en una cohorte mexicana y evaluar su asociación con el antecedente familiar de diabetes (AFD). Métodos: Se realizó un estudio de cohorte retrospectivo unicéntrico de pacientes sometidos a trasplante hepático (TH). El desenlace primario fue el tiempo entre el TH y el desarrollo de DMPT. El diagnóstico de DMPT fue establecido utilizando los criterios de la ADA. Se realizó un análisis de mediación que utilizó modelos de regresión de Cox ajustados y se manejó la prediabetes pretrasplante como mediador, para determinar el efecto total y el efecto directo del AFD sobre la DMPT. Resultados: Se incluyó a un total de 152 pacientes, con una mediana de seguimiento de 41 meses; 19.2% (n = 29) presentaron diabetes pretrasplante. Durante el tiempo de seguimiento, 15% de los pacientes desarrollaron DMPT (n = 23), con una tasa de incidencia de 4.71 casos/100 personas-año. La DMPT fue significativamente más elevada en pacientes con AFD en comparación con aquellos sin AFD (8.72 casos/100 personas-año vs 2.04 casos/100 personas-año, respectivamente; p = 0.001). El cociente de riesgo ajustado para el desarrollo de DMPT en los pacientes con AFD fue 4.14 (IC 95% 1.60–10.7; p = 0.005) y 3.49 (IC 95% 1.35–9.01; p = 0.010), cuando se controló por prediabetes pretrasplante. Conclusión: La incidencia de DMPT fue similar a la reportada en la mayoría de los estudios internacionales. Al igual que con la diabetes tipo 2, el AFD juega un papel importante en el desarrollo de la DMPT, incluso después de considerar la prediabetes pretrasplante. Los pacientes con AFD deben someterse a un programa metabólico más estricto.
Published: 2024
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14. Inseminate without hormonal treatment in dairy sheep farms: exploring the consequences on the sustainability of several contrasted production systems

Author: E. Laclef, E. González-García, N. Debus, P. Taillandier, C. De Boissieu, E. Morin, and A. Lurette
Subjects: Artificial Insemination, Hormone-free reproduction, Multiagent model, Small ruminants, Sustainable agriculture, Animal culture, SF1-1100
Abstract: Alternatives to hormonal treatments (HTs) in dairy sheep reproduction management are being explored in response to increasing societal concerns regarding animal welfare and food safety. However, hormone-free reproduction implies higher variability in flock performances and additional constraints for timely synchronised artificial insemination (AI) in the flock, impacting the diffusion of genetic progress. The use of the male effect, a well-known practice to induce synchronised oestrus, combined with precision tools (e.g., heat detector), is a plausible way to implement AI without HT in dairy sheep farms. To date, the consequences of such alternative reproduction management on the whole farm sustainability remain unknown. To anticipate these potential impacts, a multiagent model (REPRIN’OV) was used to simulate dairy sheep farms’ sustainability indicators (biotechnical, economic, environmental and workload). A reproduction management scenario, including the use of the male effect followed by AI on the adult ewes (HFAI), was simulated and compared to the current reproduction management of four case study farms (Early_conv, Late_conv, Early_org and Late_org). They were selected to represent the different agricultural models (Conventional or Organic) and reproduction seasons (Early − during spring, out of ewes’ natural reproduction season − or Late −from early summer to the end of autumn) of the Roquefort Basin’s farms in Southern France. Simulation results showed that the HFAI scenario had different consequences depending on the farm’s production system type. A negative effect on most key sustainability indicators of the Conv farms was observed, as a significant reduction in the fertility rate, in the proportion of young ewes born from AI (−54% in both farms; P
Published: 2024
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15. Safe living after transplantation or chemotherapy

Author: Marian G. Michaels and Blanca E. Gonzalez
Subjects: medicine.medical_specialty, Chemotherapy, Hospital setting, business.industry, medicine.medical_treatment, Cancer therapy, Cancer, Immunosuppression, Disease, medicine.disease, Graft function, Transplantation, medicine, Intensive care medicine, business
Abstract: Ideally, children undergoing transplantation are able to live as full and rich a life as possible with a new organ or bone marrow. Likewise, in the ideal world children with cancer are able to enjoy life outside the hospital setting. However, cancer therapy or immunosuppression used to maintain graft function or avoid graft-versus-host disease puts the child at increased risk for infections that could otherwise be benign. Although transplantation is not meant to put a child in a bubble, it is critical for caregivers and the patient to understand exposure risks in the environment so that they can take precautions against many of the potential microbes. This chapter reviews some of the types of infection that can occur via direct contact, aerosolization, or ingestion and provides suggestions for preventive strategies to help children who have undergone solid organ transplantation or hematopoietic stem cell transplant thrive once they leave the hospital. Many of these same concepts can be applied to children undergoing cancer treatments. Extrapolation from adults and common sense are often relied on when definitive pediatric studies are not available to help inform the recommendations.
Published: 2021

16. Contributors

Author: Yeh-Chung Chang, Andrew Barbas, Jasmeen Dara, Christopher C. Dvorak, Neil Patel, Abby Green, Rebecca Pellett Madan, Lara A. Danziger-Isakov, Marian G. Michaels, Michael D. Green, Gabriela M. Marón Alfaro, Hayley A. Gans, Michele Estabrook, Monica I. Ardura, Brian T. Fisher, Lillian Sung, Klara M. Posfay-Barbe, Natasha Halasa, Matthew S. Kelly, Michael A. Silverman, Joshua Wolf, Jeffrey S. Gerber, Michael J. Smith, Ibukunoluwa C. Akinboyo, Dawn Nolt, Blanca E. Gonzalez, Mehreen Arshad, Andrew Nowalk, Pranita D. Tamma, Daniel Dulek, Victoria A. Statler, Flor M. Munoz, Philana Ling Lin, Tanvi Sharma, Thomas Gross, Upton D. Allen, William J. Muller, Betsy C. Herold, Debra J. Lugo, Danielle M. Zerr, Alpana Waghmare, Janet A. Englund, Diana F. Florescu, Erica J. Stohs, Benjamin L. Laskin, Hans H. Hirsch, William J. Steinbach, Rachel L. Wattier, Jennifer E. Schuster, Philip Lee, David L. Goldman, John C. Christenson, Thomas G. Fox, Sharon F. Chen, Grant C. Paulsen, Paul K. Sue, Catherine Burton, Benjamin Hanisch, Ivan A. Gonzalez, Terri Stillwell, Inci Yildirim, Elizabeth Doby Knackstedt, Erick F. Mayer Arispe, and Andi L. Shane
Published: 2021

17. Seroprevalence of Toxoplasma gondii in free-range pigs in northern Peru

Author: Claudio Muro, Robert H. Gilman, Carlos Alonso Flores, Claudia Palacios, Seth E. O’Neal, Maritza Calderon, Luis A. Gomez-Puerta, Juan A. Jimenez, and Armando E. Gonzalez
Subjects: 0301 basic medicine, pig, Veterinary medicine, Swine, Range (biology), retrospective study, polymerase chain reaction, purl.org/pe-repo/ocde/ford#3.03.07 [https], Antibodies, Protozoan, Seroprevalence, hemagglutination, law.invention, Western blotting, immunoglobulin G, 0302 clinical medicine, Seroepidemiologic Studies, law, Peru, SAG1, Swine Diseases, disease transmission, 030108 mycology & parasitology, Transmission (mechanics), female, immunodetection, purl.org/pe-repo/ocde/ford#4.03.00 [https], Toxoplasma, environment, Toxoplasmosis, 030231 tropical medicine, prevalence, animal experiment, Toxoplasma gondii, Western blot, Biology, Article, animal tissue, 03 medical and health sciences, male, parasitic diseases, medicine, Animals, controlled study, immunofluorescence, protein expression, nonhuman, General Veterinary, Foodborne pathogen, slaughterhouse, medicine.disease, biology.organism_classification, Serum samples, enzyme linked immunosorbent assay, Toxoplasmosis, Animal, Parasitology
Abstract: Toxoplasma gondii is an important foodborne pathogen worldwide, with undercooked meat as the main source of human transmission. In this study, we determined the seroprevalence of T. gondii in free-range pigs from two adjacent villages in the Tumbes region of northern Peru, El Tutumo and Nuevo Progreso. We randomly selected 100 pig serum samples collected during a prior study and processed these using Western Blot to detect IgG anti-T. gondii antibodies. Results indicated a prevalence of 32% (32/100) to T. gondii in pigs. Free-ranging pigs from northern Peru represent a substantial risk for transmission of T. gondii to humans.
Published: 2021

18. Evaluación de los costes asociados a la enfermedad de pacientes con linfoma cutáneo de células T en España: análisis en función del estadio clínico (estudio MICADOS)

Author: B. Navarro Matilla, P.L. Ortiz Romero, R.M. Pujol Vallverdú, A. Combalia Escudero, I. Zapata Paz, E. González Barca, C. Muniesa Montserrat, M. Morillo Andújar, A. Pérez Ferriols, C. Román Curto, R. Fernández de Misa Cabrera, M. Hospital Gil, A. Marín Niebla, P.J. Rios Rull, F. de la Cruz Vicente, R.M. Izu Belloso, A. Martín García-Sancho, M.E. Parera Amer, R. Córdoba Mascuñano, M.D. Ramón Quiles, A. Saus Carreres, R. del Campo García, S. Machan, P. Viguera Ester, and J. Blanco Garnelo
Subjects: Mycosis fungoides, Sézary syndrome, Cost of disease, Pharmacoeconomics, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract: Resumen: Antecedentes y objetivo: No se dispone de datos españoles sobre el coste asociado al linfoma cutáneo de células T (LCCT). Además, la incorporación de nuevos tratamientos hace necesario analizar el coste real de la enfermedad. El estudio MICADOS analizó dos objetivos principales: Por un lado, evaluó el impacto en la calidad de vida en los pacientes con LCCT, y por otro lado, estudió los costes de la enfermedad. En esta publicación se recoge el segundo de los objetivos del estudio. Métodos: El coste de la enfermedad se estudió bajo la perspectiva del Sistema Nacional de Salud (SNS) con un horizonte temporal de un año. Participaron 23 dermatólogos y hematólogos de 15 hospitales públicos españoles. Se incluyeron pacientes adultos con LCCT del tipo micosis fungoide (MF) y síndrome de Sézary (SS). Resultados: Se incluyeron 141 pacientes, el 57,4% masculinos, con una edad media de 63,6 años (IC 95%: 61,4-65,7). Los costes directos anuales medios por pacientes del estudio fueron de 34.214€, siendo de 11.952,47€ en estadio I, 23.506,21€ en estadio II, 38.771,81€ en estadio III y 72.748,84€ en estadio IV. El coste anual directo total estimado de todos los pacientes en España con MF/SS resultó en 78.301.171€, donde el 81% de los costes fueron atribuibles a pacientes en estadio I, el 7% al estadio II, el 6% al estadio III y el 6% al estadio IV. Conclusiones: Este estudio ofrece una evaluación precisa del coste directo del LCCT en pacientes con MF/SS en España, mostrando costes que varían sustancialmente en función del estadio. Los costes soportados por el paciente y los costes indirectos deberán considerarse en futuras investigaciones. Abstract: Background and objective: The cost of treating cutaneous T-cell lymphoma (CTCL) in Spain is unknown. With the advent of new treatments, it is more important than ever to gain an accurate picture of the true costs involved. The MICADOS study had 2 primary objectives: 1) to evaluate the impact of CTCL on patient quality of life, and 2) to evaluate the costs associated with the disease. This article reports the results of the cost analysis. Methods: We estimated the cost of treating CTCL over a period of 1 year from the perspective of the Spanish National Health System. Twenty-three dermatologists and hematologists from 15 public hospitals analyzed data for adult patients with mycosis fungoides (MF) or Sézary syndrome (SS). Results: A total of 141 patients (57.4% male) with a mean age of 63.6 years (95% CI: 61.4-65.7 years) were included. The mean direct annual cost of treating CTCL was €34,214 per patient. The corresponding costs by stage were €11,952.47 for stage I disease, €23,506.21 for stage II disease, €38,771.81 for stage III disease, and €72,748.84 for stage IV disease. The total direct annual cost of treating MF/SS in public hospitals in Spain was estimated at €78,301,171; stage I disease accounted for 81% of all costs, stage II for 7%, and stages III and IV for 6% each. Conclusions: The MICADOS study offers an accurate picture of the direct cost of treating CTCL in patients with MF/SS in Spain and shows that costs vary significantly according to disease stage. Patient-borne and indirect costs should be analyzed in future studies.
Published: 2024
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19. Alternative hormone-free reproduction management of a dairy sheep flock disrupts the farm's annual feeding system calendar and its associated strategies

Author: E. Laclef, A. Lurette, P. Taillandier, P. Hassoun, S. Parisot, C. Allain, D. Portes, N. Debus, and E. González-García
Subjects: dairy sheep, hormone-free reproduction, agent-based model, feeding management, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract: ABSTRACT: Hormone-free (HF) reproduction in dairy sheep is a way to meet current societal demands, but it requires being prepared for collateral impacts on related system components. The efficiency of HF practices (e.g., using the male effect for estrus induction and synchronization) is uncertain compared with hormonal treatment (HT). For example, these practices can lead to higher variability in the flock physiological stage patterns throughout the year, which has direct consequences for feeding regimens. The objective of this work was to simulate the impacts of HF reproduction management, including artificial insemination (AI), on the temporal distribution of productive performance and nutritional requirements of a conventional dairy sheep flock. Using the REPROsheep2.0 model, 6 scenarios were compared over one typical production season for the same flock (n = 597 Lacaune ewes) intensively reared in the Roquefort region of France. These scenarios depicted reproduction with HT and AI in mid-May (Early); HT and AI in July (Summer Late); HT and AI in November (Autumn Late); and their HF versions (HF-Early; HF-Summer Late, and HF-Autumn Late, respectively). In all HF scenarios, a reduction in the number of ewes lambing and consequently in the annual milk production of the farm was observed (−1 to −7%). This affected annual performance with a subsequent decrease of total annual nutritional requirements (−2 to −6%). The HF scenarios resulted in a staggering of lambing events with a 7- to 14-d shift in the appearance of milk production peaks and related nutritional requirements compared with the HT scenarios. Transitioning from conventional to HF reproduction management, while preserving AI, would increase farm workload, lengthen milking period operations, and necessitate a readjustment of feeding management strategies with regard to available feed resources. Depending on the production season, the observed delay in the distribution of nutritional requirements could be either an attractive or an unfavorable outcome for farmers. The delay may be concordant, for example, with the recently observed impacts of climate change on seasonal forage availability in Mediterranean regions (less spring herbage production and warmer temperatures) that are affecting farmers' decision-making about the most efficient use of forage and feed resources.
Published: 2023
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20. [Translated article] Cost of Treating Cutaneous T-Cell Lymphoma in Spain: Analysis of MICADOS Study Data by Disease Stage

Author: B. Navarro Matilla, P.L. Ortiz Romero, R.M. Pujol Vallverdú, A. Combalia Escudero, I. Zapata Paz, E. González Barca, C. Muniesa Montserrat, M. Morillo Andújar, A. Pérez Ferriols, C. Román Curto, R. Fernández de Misa Cabrera, M. Hospital Gil, A. Marín Niebla, P.J. Rios Rull, F. de la Cruz Vicente, R.M. Izu Belloso, A. Martín García-Sancho, M.E. Parera Amer, R. Córdoba Mascuñano, M.D. Ramón Quiles, A. Saus Carreres, R. del Campo García, S. Machan, P. Viguera Ester, and J. Blanco Garnelo
Subjects: Micosis fungoides, Síndrome de Sézary, Coste de la enfermedad, Farmacoeconomía, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract: Background and objective: The cost of treating cutaneous T-cell lymphoma (CTCL) in Spain is unknown. With the advent of new treatments, it is more important than ever to gain an accurate picture of the true costs involved. The MICADOS study had 2 primary objectives: 1) to evaluate the impact of CTCL on patient quality of life, and 2) to evaluate the costs associated with the disease. This article reports the results of the cost analysis. Methods: We estimated the cost of treating CTCL over a period of 1 year from the perspective of the Spanish National Health System. Twenty-three dermatologists and hematologists from 15 public hospitals analyzed data for adult patients with mycosis fungoides (MF) or Sézary syndrome (SS). Results: A total of 141 patients (57.4% male) with a mean age of 63.6 years (95% CI: 61.4-65.7 years) were included. The mean direct annual cost of treating CTCL was €34,214 per patient. The corresponding costs by stage were €11,952.47 for stage I disease, €23,506.21 for stage II disease, €38,771.81 for stage III disease, and €72,748.84 for stage IV disease. The total direct annual cost of treating MF/SS in public hospitals in Spain was estimated at €78,301,171; stage I disease accounted for 81% of all costs, stage II for 7%, and stages III and IV for 6% each. Conclusions: The MICADOS study offers an accurate picture of the direct cost of treating CTCL in patients with MF/SS in Spain and shows that costs vary significantly according to disease stage. Patient-borne and indirect costs should be analyzed in future studies. Resumen: Antecedentes y objetivo: No se dispone de datos españoles sobre el coste asociado al linfoma cutáneo de células T (LCCT). Además, la incorporación de nuevos tratamientos hace necesario analizar el coste real de la enfermedad. El estudio MICADOS analizó dos objetivos principales: Por un lado, evaluó el impacto en la calidad de vida en los pacientes con LCCT, y por otro lado, estudió los costes de la enfermedad. En esta publicación se recoge el segundo de los objetivos del estudio. Métodos: El coste de la enfermedad se estudió bajo la perspectiva del Sistema Nacional de Salud (SNS) con un horizonte temporal de un año. Participaron 23 dermatólogos y hematólogos de 15 hospitales públicos españoles. Se incluyeron pacientes adultos con LCCT del tipo micosis fungoide (MF) y síndrome de Sézary (SS). Resultados: Se incluyeron 141 pacientes, el 57,4% masculinos, con una edad media de 63,6 años (IC 95%: 61,4-65,7). Los costes directos anuales medios por pacientes del estudio fueron de 34.214€, siendo de 11.952,47€ en estadio I, 23.506,21€ en estadio II, 38.771,81€ en estadio III y 72.748,84€ en estadio IV. El coste anual directo total estimado de todos los pacientes en España con MF/SS resultó en 78.301.171€, donde el 81% de los costes fueron atribuibles a pacientes en estadio I, el 7% al estadio II, el 6% al estadio III y el 6% al estadio IV. Conclusiones: Este estudio ofrece una evaluación precisa del coste directo del LCCT en pacientes con MF/SS en España, mostrando costes que varían sustancialmente en función del estadio. Los costes soportados por el paciente y los costes indirectos deberán considerarse en futuras investigaciones.
Published: 2024
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21. Relationship between the anterior forebrain mesocircuit and the default mode network in the structural bases of disorders of consciousness

Author: Adrian M. Owen, Nicholas D. Lant, Laura E. Gonzalez-Lara, and Davinia Fernández-Espejo
Subjects: Male, Precuneus, lcsh:RC346-429, 0302 clinical medicine, Traumatic brain injury, Thalamus, Neural Pathways, Basal ganglia, Default mode network, Minimally conscious state, Disorders of consciousness, Vegetative state, 05 social sciences, White matter, Regular Article, Diffusion Tensor Imaging, Globus pallidus, medicine.anatomical_structure, Neurology, DTI, Consciousness Disorders, lcsh:R858-859.7, Female, Tractography, Adult, Cognitive Neuroscience, Biology, Anterior forebrain mesocircuit, lcsh:Computer applications to medicine. Medical informatics, 050105 experimental psychology, Young Adult, 03 medical and health sciences, Prosencephalon, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, lcsh:Neurology. Diseases of the nervous system, Hypoxic-ischemic brain injury, medicine.disease, Corpus Striatum, Diffusion Magnetic Resonance Imaging, nervous system, Forebrain, Hypoxic–ischemic brain injury, Neurology (clinical), Neuroscience, 030217 neurology & neurosurgery
Abstract: The specific neural bases of disorders of consciousness (DOC) are still not well understood. Some studies have suggested that functional and structural impairments in the default mode network may play a role in explaining these disorders. In contrast, others have proposed that dysfunctions in the anterior forebrain mesocircuit involving striatum, globus pallidus, and thalamus may be the main underlying mechanism. Here, we provide the first report of structural integrity of fiber tracts connecting the nodes of the mesocircuit and the default mode network in 8 patients with DOC. We found evidence of significant damage to subcortico-cortical and cortico-cortical fibers, which were more severe in vegetative state patients and correlated with clinical severity as determined by Coma Recovery Scale—Revised (CRS-R) scores. In contrast, fiber tracts interconnecting subcortical nodes were not significantly impaired. Lastly, we found significant damage in all fiber tracts connecting the precuneus with cortical and subcortical areas. Our results suggest a strong relationship between the default mode network – and most importantly the precuneus – and the anterior forebrain mesocircuit in the neural basis of the DOC., Highlights • We assess the integrity of the fibers connecting the anterior forebrain mesocircuit and the default mode network in DOC. • DOC patients have significantly lower FA in subcortico-cortical and cortico-cortical fiber tracts relative to controls. • The damage in these tracts is more severe in vegetative state patients than those who are at least minimally conscious. • Individual tract analysis revealed significant damage in all tracts connecting to the precuneus in DOC patients.
Published: 2016

22. Cuero cabelludo sensible: diagnóstico y manejo práctico

Author: A. Guerra-Tapia and E. González-Guerra
Subjects: Sensitive scalp, Sensitive skin, Trichodynia, Transient receptor potential cation channel, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract: Resumen: El cuero cabelludo sensible es una piel sensible de localización especial. Puede ser primario, cuando se presenta sin enfermedad del cuero cabelludo, y secundario cuando es atribuible a procesos como psoriasis, dermatitis seborreica, dermatitis atópica y otros.Las manifestaciones clínicas de la forma primaria son subjetivas. El escozor, picor, tricodinia y sensaciones disestésicas son el motivo de consulta, muy a menudo coincidiendo con alopecia. Clínicamente la piel del cuero cabelludo puede ser normal o eritematosa. No hay datos de laboratorio o histológicos específicos para un diagnóstico objetivo. Los factores desencadenantes son endógenos como el estrés y alteraciones emocionales y psicopatológicas, o ambientales como los tópicos inadecuados y los cosméticos. El tratamiento debe ser personalizado, incluyendo pimecrólimus, la hidratación con ácido hialurónico, y la mesoterapia con plasma rico en factores de crecimiento. Abstract: Sensitive scalp is sensitive skin located on the scalp. Sensitivity is considered primary in the absence of an associated scalp disorder and secondary when caused by conditions such as psoriasis, seborrheic dermatitis, and atopic dermatitis.The clinical manifestations of primary sensitive scalp are subjective. Common presenting symptoms are burning, itching, trichodynia, and dysesthesia, often coinciding with hair loss. Clinically, the skin appears normal or red. An objective diagnosis based on laboratory or histologic findings is not possible. Triggers may be endogenous (e.g., stress and emotional or psychopathological disturbances) or exogeneous (e.g., topical products and cosmetics). Treatment must be individualized. Options include pimecrolimus, hydration with hyaluronic acid, and mesotherapy with plasma rich in growth factors.
Published: 2023
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23. Seizure Suppression by High Frequency Optogenetic Stimulation Using In Vitro and In Vivo Animal Models of Epilepsy

Author: Luis E. Gonzalez-Reyes, Chia Chu Chiang, Thomas P. Ladas, and Dominique Durand
Subjects: Male, Biophysics, Hippocampus, Mice, Transgenic, Stimulation, In Vitro Techniques, Optogenetics, Article, lcsh:RC321-571, GABA Antagonists, Mice, Epilepsy, Receptors, GABA, Seizures, In vivo, medicine, Animals, Picrotoxin, 4-Aminopyridine, 4-AP, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Neurons, GABAA receptor, Chemistry, General Neuroscience, medicine.disease, CA3 Region, Hippocampal, Disease Models, Animal, Electrophysiology, High frequency stimulation, Excitatory postsynaptic potential, Seizure suppression, Neurology (clinical), Neuroscience
Abstract: Background Electrical high frequency stimulation (HFS) has been shown to suppress seizures. However, the mechanisms of seizure suppression remain unclear and techniques for blocking specific neuronal populations are required. Objective The goal is to study the optical HFS protocol on seizures as well as the underlying mechanisms relevant to the HFS-mediated seizure suppression by using optogenetic methodology. Methods Thy1-ChR2 transgenic mice were used in both vivo and in vitro experiments. Optical stimulation with pulse trains at 20 and 50 Hz was applied on the focus to determine its effects on in vivo seizure activity induced by 4-AP and recorded in the bilateral and ipsilateral-temporal hippocampal CA3 regions. In vitro methodology was then used to study the mechanisms of the in vivo suppression. Results Optical HFS was able to generate 82.4% seizure suppression at 50 Hz with light power of 6.1 mW and 80.2% seizure suppression at 20 Hz with light power of 2.0 mW. The suppression percentage increased by increasing the light power and saturated when the power reached above-mentioned values. In vitro experimental results indicate that seizure suppression was mediated by activation of GABA receptors. Seizure suppression effect decreased with continued application but the suppression effect could be restored by intermittent stimulation. Conclusions This study shows that optical stimulation at high frequency targeting an excitatory opsin has potential therapeutic application for fast control of an epileptic focus. Furthermore, electrophysiological observations of extracellular and intracellular signals reveled that GABAergic neurotransmission activated by optical stimulation was responsible for the suppression.
Published: 2014

24. PhenoBR: a model to phenotype body condition dynamics in meat sheep

Author: T. Macé, E. González-García, G. Kövér, D. Hazard, and M. Taghipoor
Subjects: Body reserves’ dynamic, Mathematical model, Negative energy balance, Resilience, Ruminant, Animal culture, SF1-1100
Abstract: In situations of negative energy balance (NEB) due to feed scarcity or high physiological demands, body energy reserves (BRs), mainly stored in adipose tissues, become the main sources of energy for ruminants. The capacity to mobilise and restore such BRs in response to different challenges is of major concern in the current context of breeding for resilience. Body condition score (BCS) is a common, practical indicator of BR variations throughout successive productive cycles, and quantitative tools for characterising such dynamics at the individual level are still lacking. The main objective of this work was to characterise body condition dynamics in terms of BR mobilisation and accretion capacities of meat sheep during their productive lifespan through a modelling approach, using BCS measurements. The animal model used in this work was the reproductive meat ewe (n = 1 478) reared in extensive rangeland. Regular measurements of BCS for each productive cycle were used as the indicator of BR variations. A hybrid mathematical model and a web interface, called PhenoBR, were developed to characterise ewes’ BCS variations through four synthetic and biologically meaningful parameters for each productive cycle i: BR accretion rate (kbi), BR mobilisation rate (kpi), plus the time of onset and the duration of the BR mobilisation, tbi and ΔTi, respectively. The model PhenoBR converged for all the ewes included in the analysis. Estimation of the parameters indicated the inter-individual variability for BR accretion and mobilisation rates, and the length of the mobilisation period. The present study is a proof of concept that the combination of data-driven and concept-driven models is required for the estimation of biologically meaningful parameters that describe body reserve dynamics through consecutive productive cycles. Individual characterisation of animals by these parameters makes it possible to rank them for their efficiency in the use of body reserves when facing NEB challenges. Such parameters could contribute to better management and decision-making by farmers and advisors, e.g. by adapting feeding systems to the individual characteristics of BR dynamics, or by geneticists as criteria to develop future animal breeding programmes including BR dynamics for more robust and resilient animals.
Published: 2023
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25. Variation in developmental patterns among elite wheat lines and relationships with yield, yield components and spike fertility

Author: Gustavo A. Slafer, Simon Griffiths, Gemma Molero, Oscar E. Gonzalez-Navarro, and Matthew P. Reynolds
Subjects: 0106 biological sciences, Germplasm, Yield (engineering), Grain number, Growing season, Soil Science, 01 natural sciences, Article, Anthesis, Stem elongation, Genetic variation, Fruiting efficiency, Triticum aestivum L, 2. Zero hunger, biology, Phenology, Crop yield, food and beverages, 04 agricultural and veterinary sciences, biology.organism_classification, Agronomy, Seedling, 040103 agronomy & agriculture, Spike fertility, 0401 agriculture, forestry, and fisheries, Agronomy and Crop Science, 010606 plant biology & botany
Abstract: Highlights • Time to terminal spikelet and from then to anthesis were largely independent. • The length of the stem elongation phase was slightly but positively related to grains per m2. • Fruiting efficiency was critical for determining grain number, but it was also negatively related to grain weight. • The length of the stem elongation phase seems to have imposed an upper threshold for fruiting efficiency., Developmental patterns strongly influence spike fertility and grain number, which are primarily determined during the stem elongation period (i.e. time between terminal spikelet phase and anthesis). It has been proposed that the length of the stem elongation phase may, to an extent, affect grain number; thus it would be beneficial to identify genetic variation for the duration of this phase in elite germplasm. Variation in these developmental patterns was studied using 27 elite wheat lines in four experiments across three growing seasons. The results showed that the length of the stem elongation phase was (i) only slightly related to the period from seedling emergence to terminal spikelet, and (ii) more relevant than it for determining time to anthesis. Thus, phenological phases were largely independent and any particular time to anthesis may be reached with different combinations of component phases. Yield components were largely explained by fruiting efficiency of the elite lines used: the relationships were strongly positive and strongly negative with grain number and with grain weight, respectively. Although fruiting efficiency showed a positive trend with the duration of stem elongation that was not significant, a boundary function (which was highly significant) suggests that the length of this phase may impose an upper threshold for fruiting efficiency and grain number, and that maximum values of fruiting efficiency may require a relatively long stem elongation phase.
Published: 2016

26. Complicaciones neurológicas en el postoperatorio inmediato de cirugía cardiaca: todavía un largo camino por recorrer

Author: A. Ferrer-Barba, J.L. Fernandez-Trisac, E. Gonzalez-Garcia, C. Ramil-Fraga, Francisco Portela-Torrón, I. Gonzalez-Rivera, and Alejandro Avila-Alvarez
Subjects: Gynecology, Nervous system, medicine.medical_specialty, Complications, business.industry, Pediatrics, Perinatology and Child Health, Medicine, business, Pediatrics, RJ1-570, Congenital heart disease
Abstract: Resumen: Introducción: Existe una creciente preocupación por las complicaciones neurológicas asociadas a las cardiopatías congénitas y a la cirugía cardiaca infantil. Material y métodos: Estudio observacional retrospectivo de casos y controles de las cirugías cardiacas infantiles y su postoperatorio en cuidados intensivos durante un período de 10 años. Se seleccionaron dos controles por cada caso, ajustados por el mismo grado de complejidad quirúrgica. Resultados: Se estudiaron 900 cirugías. Se detectaron 38 complicaciones neurológicas (4,2%), de las cuales 21 (55,3%) implicaban al sistema nervioso periférico y 17 (44,7%) al sistema nervioso central. Las complicaciones del sistema nervioso central (1,9% del total) fueron 8 convulsiones, 4 accidentes cerebrovasculares, 4 encefalopatías hipóxico-isquémicas y un déficit neurológico reversible. Un 35,3% mostró afectación al alta y un 17,6% falleció. Se encontró una diferencia estadísticamente significativa en el tiempo de circulación extracorpórea (p = 0,009), el tiempo de isquemia (p = 0,12), los días de estancia en cuidados intensivos (p = 0,001), días de ventilación mecánica (p = 0,004) y días de soporte inotrópico (p = 0,001). Conclusiones: La incidencia de complicaciones neurológicas en nuestra serie es similar a la descrita previamente. Las convulsiones son la manifestación clínica más común. Las complicaciones del sistema nervioso central se asocian con un aumento de la morbilidad, una mayor estancia hospitalaria y un mayor consumo de recursos. Es necesario establecer medidas en el pre y post-operatorio, así como durante la cirugía, encaminadas a su prevención y diagnóstico precoz. Abstract: Introduction: There has been an increasing concern over the neurological complications associated with congenital heart disease and cardiac surgery. Material and methods: We performed a retrospective, case-control, observational review of the postoperative period in the intensive care unit of patients undergoing cardiac surgery over the past 10 years. We selected 2 control patients for each case, matched for surgical complexity. Results: A total of 900 patients were reviewed. We found 38 neurological complications (4.2%), of which 21 (55.3%) were in the peripheral nervous system and 17 (44.7%) in the central nervous system. The complications involving the central nervous system (1.9% of total) consisted of 8 seizures, 4 cerebrovascular accidents, 4 hypoxic-ischemic encephalopathy events, and 1 reversible neurological deficit. At the time of discharge, 35.3% were symptomatic and 17.6% had died. Patients with neurological complications had a longer bypass time (P=.009), longer aortic cross time (P=.012), longer hospitalization in intensive care (P=.001), longer duration of mechanical ventilation (P=.004) and an increased number of days under inotropic support (P=.001). Conclusions: Our incidence of neurological complications after cardiac surgery is similar to that previously described. Clinical seizures are the most common complication. Central nervous system complications are associated with a higher morbidity and hospitalization time. Units caring for patients with congenital heart disease must implement neurological monitoring during and after cardiac surgery to prevent and to detect these complications earlier.
Published: 2012

27. Corrigendum: 'Measurement of 73Ge(n,γ) cross sections and implications for stellar nucleosynthesis' [Phys. Lett. B 790 (2019) 458–465]

Author: C. Lederer-Woods, U. Battino, P. Ferreira, A. Gawlik, C. Guerrero, F. Gunsing, S. Heinitz, J. Lerendegui-Marco, A. Mengoni, R. Reifarth, A. Tattersall, S. Valenta, C. Weiss, O. Aberle, J. Andrzejewski, L. Audouin, V. Bécares, M. Bacak, J. Balibrea, M. Barbagallo, S. Barros, F. Bečvář, C. Beinrucker, F. Belloni, E. Berthoumieux, J. Billowes, D. Bosnar, M. Brugger, M. Caamaño, F. Calviño, M. Calviani, D. Cano-Ott, F. Cerutti, E. Chiaveri, N. Colonna, G. Cortés, M.A. Cortés-Giraldo, L. Cosentino, L.A. Damone, K. Deo, M. Diakaki, M. Dietz, C. Domingo-Pardo, R. Dressler, E. Dupont, I. Durán, B. Fernández-Domínguez, A. Ferrari, P. Finocchiaro, R.J.W. Frost, V. Furman, K. Göbel, A.R. García, I. Gheorghe, T. Glodariu, I.F. Gonçalves, E. González-Romero, A. Goverdovski, E. Griesmayer, H. Harada, T. Heftrich, A. Hernández-Prieto, J. Heyse, D.G. Jenkins, E. Jericha, F. Käppeler, Y. Kadi, T. Katabuchi, P. Kavrigin, V. Ketlerov, V. Khryachkov, A. Kimura, N. Kivel, I. Knapova, M. Kokkoris, M. Krtička, E. Leal-Cidoncha, H. Leeb, M. Licata, S. Lo Meo, R. Losito, D. Macina, J. Marganiec, T. Martínez, C. Massimi, P. Mastinu, M. Mastromarco, F. Matteucci, E. Mendoza, P.M. Milazzo, F. Mingrone, M. Mirea, S. Montesano, A. Musumarra, R. Nolte, F.R. Palomo-Pinto, C. Paradela, N. Patronis, A. Pavlik, J. Perkowski, J.I. Porras, J. Praena, J.M. Quesada, T. Rauscher, A. Riego-Perez, M. Robles, C. Rubbia, J.A. Ryan, M. Sabaté-Gilarte, A. Saxena, P. Schillebeeckx, S. Schmidt, D. Schumann, P. Sedyshev, A.G. Smith, A. Stamatopoulos, S.V. Suryanarayana, G. Tagliente, J.L. Tain, A. Tarifeño-Saldivia, L. Tassan-Got, A. Tsinganis, G. Vannini, V. Variale, P. Vaz, A. Ventura, V. Vlachoudis, R. Vlastou, A. Wallner, S. Warren, M. Weigand, T. Wright, and P. Žugec
Subjects: Physics, QC1-999
Published: 2023
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28. Tuberculosis en niños de 0-14 años: Cuba, 1994-2003

Author: E. Gonzalez Ochoa, MªJ Llanes Cordero, J D'fana Valdés, S. Borroto Gutiérrez, G. Abreu Suárez, J. González Valdés, and L. Armas Pérez
Subjects: Geography, Surveillance, Pediatrics, Perinatology and Child Health, Control, Trend, Tuberculosis, Cuba, Infant newborn, Humanities, Children, Pediatrics, RJ1-570, West indies
Abstract: Introducción: La ocurrencia de tuberculosis en niños es un signo de transmisión continua de la infección. En este estudio describimos la distribución y tendencia de las tasas de incidencia de casos nuevos de tuberculosis de niños menores de 15 años de edad en Cuba. Métodos: Se estimaron las tasas de incidencia y su tendencia, por provincias y grupos de edades del período 1994-2003. Se determinó la distribución porcentual, porcentaje de variación global y promedio anual de las tasas, así como las tasas y porcentajes de tuberculosis según su localización. Resultados: La tasa de incidencia disminuyó de 0,76 × 105 en 1994 a 0,31 en 2003 (59,2 % reducción global y 6,6 % reducción anual como promedio). En 1995 se notificó la tasa más alta 1,06 × 105 (26 casos). En casi todas las provincias la tendencia de la incidencia fue descendente, excepto en Ciudad Habana, Sancti Spíritus, Santiago de Cuba e Isla de la Juventud. El 69,6 % de la tuberculosis infantil fue de localización pulmonar. Los grupos de edades de 10-14 años (35,6 %) y 1-4 (35,2%) presentaron los porcentajes más altos dentro de la población infantil afectada. Conclusiones: La tuberculosis es muy poco frecuente y más bien rara en menores de un año y en general presenta notificación muy baja en todo el país con una tendencia global descendente mantenida. : Introduction: Tuberculosis in infants and children is a sign of continuous transmission. The present article describes the distribution and the trend in incidence rates of new tuberculosis cases in 0-15-year-olds in Cuba. Methods: Incidence rates and their trend were estimated by provinces and age groups for the 1994-2003 period. Distribution and overall variation percentages, annual average rates, and rates and percentages according to classification were determined. Results: The incidence rate decreased from 0.76 × 105 in 1994 to 0.31 in 2003 (59.2 % of the overall reduction and 6.6 % of the annual average reduction). The highest rate (1.06 × 105) was found in 1995 (26 cases). In almost all provinces, the incidence trend decreased, except in the City of Havana, Sancti Spíritus, Santiago de Cuba, and the Isle of Youth. Childhood tuberculosis was mainly pulmonary (69.6 %). Among the affected population, the highest percentages were found in the groups aged 10-14 years (35.6%) and 1-4 years (35.2%). Conclusions: Tuberculosis is infrequent and is extremely uncommon in infants. Notification is low throughout the country and the overall trend shows a steady decrease.
Published: 2007

29. Anthropological Approaches to the Study of Education: The United States and Beyond

Author: Bradley A U Levinson, Norma E Gonzalez, and Kathryn Anderson-Levitt
Subjects: Cultural analysis, Anthropology, Political science, Ethnography, Gender studies, Transculturation, Cultural transmission in animals
Abstract: This article is a revision of the previous edition article by R. Goodman, volume 9, pp. 4192–4196, © 2001, Elsevier Ltd.
Published: 2015

30. [Translated article] Sensitive Scalp: Diagnosis and Practical Management

Author: A. Guerra-Tapia and E. González-Guerra
Subjects: Cuero cabelludo sensible, Piel sensible, Tricodinia, Receptor de potencial transitorio vaniloide, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract: Sensitive scalp is sensitive skin located on the scalp. Sensitivity is considered primary in the absence of an associated scalp disorder and secondary when caused by conditions such as psoriasis, seborrheic dermatitis, and atopic dermatitis.The clinical manifestations of primary sensitive scalp are subjective. Common presenting symptoms are burning, itching, trichodynia, and dysesthesia, often coinciding with hair loss. Clinically, the skin appears normal or red. An objective diagnosis based on laboratory or histologic findings is not possible. Triggers may be endogenous (e.g., stress and emotional or psychopathological disturbances) or exogeneous (e.g., topical products and cosmetics). Treatment must be individualized. Options include pimecrolimus, hydration with hyaluronic acid, and mesotherapy with plasma rich in growth factors. Resumen: El cuero cabelludo sensible es una piel sensible de localización especial. Puede ser primario, cuando se presenta sin enfermedad del cuero cabelludo, y secundario, cuando es atribuible a procesos como psoriasis, dermatitis seborreica, dermatitis atópica y otros.Las manifestaciones clínicas de la forma primaria son subjetivas. El escozor, el picor, la tricodinia y las sensaciones disestésicas son el motivo de consulta, muy a menudo coincidiendo con alopecia. Clínicamente la piel del cuero cabelludo puede ser normal o eritematosa. No hay datos de laboratorio o histológicos específicos para un diagnóstico objetivo. Los factores desencadenantes son endógenos, como el estrés y las alteraciones emocionales y psicopatológicas, o ambientales, como los tópicos inadecuados y los cosméticos. El tratamiento debe ser personalizado, incluyendo pimecrolimus, la hidratación con ácido hialurónico y la mesoterapia con plasma rico en factores de crecimiento.
Published: 2023
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31. The Molecular Cell Biology of Anterior Pituitary Cells

Author: Richard Bertram and Arturo E. Gonzalez-Iglesias
Subjects: medicine.medical_specialty, Cell type, Cell signaling, Enteroendocrine cell, Biology, Cell biology, Paracrine signalling, medicine.anatomical_structure, Endocrinology, Anterior pituitary, Internal medicine, medicine, Autocrine signalling, Endocrine gland, Hormone
Abstract: The anterior pituitary is an endocrine gland responsible for secreting hormones that regulate a wide range of functions. The traditional view of the anterior pituitary holds that there are five endocrine cell types, which are classified on the basis of the expression of a specific hormone and response to specific hypothalamic-releasing hormones. However, the recent finding of polyhormonal cells and multi-responsive cells may blur this division. In addition, remarkable heterogeneity is observed within each of these cell types. An impressive signaling toolkit represented by a broad variety of receptors and ion channels, gives rise to distinctive patterns of electrical activity and Ca2+ signaling which in turn underlie cell type-specific secretion profiles. Intricate autocrine and paracrine interactions add another layer of complexity to their repertoire. These cells are not homogeneously distributed in the gland but form numerous intercrossing strands of single cells whose connectivity and location is remarkably dynamic. Experience-dependent plasticity has been recently shown for the lactotroph cell network, allowing adaptation to meet changing physiological demands, a feature that is likely shared by other endocrine cells to meet their vital role in homeostatic control.
Published: 2014

32. List of Contributors

Author: Ana Aranda, Richard Bertram, Andrew A. Bremer, Maria Luisa Brandi, Sally A. Camper, Nancy Carrasco, Luisella Cianferotti, P. Michael Conn, Constanza Contreras Jurado, Lique M. Coolen, Pascale Crépieux, Francisco Dominguez, Shereen Ezzat, Laurine Gagniac, Nathalie Gallay, Peter D. Gluckman, Karen Gomez-Hernandez, Arturo E. Gonzalez-Iglesias, Robert L. Goodman, Rodolfo Guardado-Mendoza, Florian Guillou, Mark A. Hanson, Astrid C. Hauge-Evans, Tomohiro Ishii, Peter M. Jones, Gerard Karsenty, Michael N. Lehman, Felicia M. Low, Olaia Martínez-Iglesias, Jan M. McAllister, Walter L. Miller, Bhavi Modi, Nicolas Musi, Juan Pablo Nicola, Aurea Orozco, María Inés Pérez Millán, Shanta J. Persaud, Anne Poupon, Alvin C. Powers, Eric Reiter, Ludivina Robles-Osorio, Lidia Ruiz-Llorente, Carlos Simon, Juan Carlos Solís-S, Jerome F. Strauss, Toru Tateno, Manuel Tena-Sempere, Judith L. Turgeon, Alfredo Ulloa-Aguirre, Carlos Valverde-R, Michael D. Walker, and Dennis W. Waring
Published: 2014

33. Magnetic Resonance Spectroscopy (MRS) of the Brain

Author: N. Fayed and E. Gonzalez-Toledo
Subjects: Clinical Practice, Epilepsy, Pathology, medicine.medical_specialty, nervous system, business.industry, Medicine, Substantia nigra, Disease, business, medicine.disease, Brain neoplasm, Stroke
Abstract: Magnetic resonance spectroscopy (MRS) is widely available in major institutions for clinical practice and research. In this chapter, the use of MRS in neurodegenerative diseases such as Alzheimer's disease, Parkinson disease (disorders of the substantia nigra), psychiatric and vascular disorders, intracranial neoplasms, infections, demyelinating diseases, developmental disorders, and epilepsy are covered. The topics are based on the authors' experience and supported by comprehensive references.
Published: 2014

34. A measurement of the Z0 leptonic partial widths and the vector and axial vector coupling constants

Author: Aa Vorobyov, Francesco Marzano, T. Angelov, J.M. Qian, Philip Kaaret, A. Engler, N. Smirnov, W. Krenz, G. Hu, J.M. Thenard, A.M. Cartacci, Carlos Willmott, L. Ludovici, H.R. Dimitrov, L. Urbàn, V. Plyaskin, U. Becker, G. Rahal-Callot, D.N. Mao, C. Souyri, E. Thomas, Sandra Consuegra Rodríguez, H. T. Li, R.J. Wu, F. J. Eppling, D. S. Yan, S.S. Gau, An.A. Vorobyov, T. Matsuda, F. Cesaroni, L. Leistam, S. M. Ting, Federico Carminati, M. Gailloud, M.L. Chen, Yu. Galaktionov, L. Baksay, K. Schultze, V.G. Shevchenko, Boleslaw Wyslouch, H.J. Schreiber, C.Y. Chien, H.F. Chen, Y.P. Tong, P.G. Seiler, J. Alcaraz, S. Patricelli, E. Tarkovsky, A. Heavey, Q. Ye, V. Schegelsky, M. Gettner, D. Lanske, O. Adriani, G.Q. Hu, T. Kramer, J.C. Sens, Peter Denes, M. Sachwitz, C. Maña, Qi An, S. Lökös, R. Raghavan, Marcella Diemoz, Paolo Bagnaia, J. J. Blaising, T. Ferguson, M. G. Alviggi, K.S. Yang, Samuel C.C. Ting, Th. Rombach, J. P. Burq, G. Von Dardel, K. N. Qureshi, Steven Goldfarb, Marco Meschini, D. Kirkby, J. Schütte, G. Landi, F.G. Hartjes, Laurent Vuilleumier, U. Herten, T. Böhringer, X.R. Shi, D.W. Schmitz, B. N. Jin, H. Haan, Simonetta Gentile, E. Isiksal, D.H. Zhang, Igor Vorobiev, Lamberto Luminari, Y. Peng, S. Schulte, C. Pols, P. Marchesini, B. Stöhr, Ming Zeng, P. Vikas, R. Leiste, Robert Clare, X. Lue, M. Röhner, S. C. Yeh, Antonino Zichichi, J.M. Lubbers, F. Bruyant, V. Morgunov, T. Foreman, Kenneth Francis Read, Egidio Longo, U. K. Chaturvedi, H. Rykaczewski, D. Harting, Thomas Hebbeker, Panos A Razis, Y.J. Pei, Y. S. Lu, Paul Lecoq, G. Conforto, J. Fehlmann, I. Vetlitsky, P. Blömeke, R. L. Sumner, W. Ruckstuhl, S. Rosier-Lees, T. Riemann, M. Napolitano, P. Schmitz, B. Bertucci, Alexei Klimentov, K. Deiters, D. Zhang, D. P. Stickland, P. Le Coultre, Yu. Kamyshkov, R.C. Ball, Adrian Biland, G. Schwering, J. Ulbricht, Raffaello D'Alessandro, Dimitri Bourilkov, C. Camps, Nicanor Colino, L. Zehnder, Y.F. Mao, H. Vogt, R. T. Van de Walle, S. X. Wu, A. Gordeev, M. Micke, Lawrence W. Jones, J. Wenninger, Y. Karyotakis, K. Sudhakar, Y. Mir, C. H. Ye, G. Fernandez, G. H. Wang, K. Hangarter, H. S. Chen, Helmut Vogel, Oliver Kornadt, M. Pohl, R. Liu, Mw Gruenewald, R. Starosta, V. Pojidaev, Jérôme Rose, R. Wilhelm, C. Grinnell, Y. Mi, K. Freudenreich, Leonardo Merola, K.D. Shmakov, S. J. Fan, W. Walk, S. Banerjee, Zp Zhang, Ph. Rosselet, G. J. Bobbink, M. M. Ilyas, Pierre Lecomte, Wesley James Metzger, L.S. Hsu, L. Montanet, D. Luckey, Gy L. Bencze, G. Herten, J. P. Martin, B. Spiess, J.Y. Liao, P.V.K.S. Baba, M. Steuer, J. Onvlee, M. Bourquin, C. G. Yang, I. C. Brock, C. Chen, X. D. Cai, G. Forconi, J. Weber, Z.Q. Yang, E. Valente, M. Chemarin, E. Perrin, K. Strauch, Tariq Aziz, W. Friebel, G. Faber, M. Fabre, Corinne Goy, B. Borgia, V. Lalieu, T.J. Wenaus, S. L. Wu, Speranza Falciano, Vincenzo Innocente, R. Fabbretti, T. Azemoon, Patricia McBride, S. Morganti, Jd Burger, M. Capell, Georgi Sultanov, Jozsef Toth, Charles Timmermans, A. Kuhn, R. A. Khan, H. Akbari, G. Sauvage, V. Koutsenko, Z.Z. Xu, Gaihe Yang, J. Lettry, Claudio Luci, Suresh C Tonwar, R. Weill, G.B. Mills, A. Malinin, Mingshui Chen, M. Dhina, A. van Laak, Qun Wang, R. Dolin, Marcos Cerrada, D. Perret-Gallix, H. S. Fesefeldt, Axel König, D. J. Schotanus, J. A. Bakken, Elisabetta Gallo, R.B. Sutton, W. Lohmann, P. Lebrun, V. P. Andreev, X. L. Wang, E. Jagel, Crisostomo Sciacca, Yanwen Liu, P. J. Li, J. Schwenke, X. Y. Cui, Fridolin Dittus, J. Fay, Marco Pieri, Chenliang Wang, M. Fukushima, P. Schmitt, M. Glaubman, K. Mazumbar, G. M. Chen, S. Reucroft, Harvey B Newman, K. Hilgers, D. Güsewell, A. Chen, M. Vollmar, F. Ferroni, I. Clare, W. Wallraff, D. Wright, H. Fenker, D. Antreasyan, J. M. Le Goff, Alberto Aloisio, S. Beingessner, A. Grimes, Y. Zeng, Z.F. Gong, Th. Meinholz, S.Y. Zhang, A. L. Anderson, J. A. Rubio, P. Göttlicher, J.H. Wang, J. Mnich, P. K. Malhotra, D. Ren, Ying Wu, X. W. Tang, J. G. Branson, J. Von Rango, I. Sheer, J. F. Zhou, M. Herbert, K. Lübelsmeyer, Piero Spillantini, P. A. Piroué, G. Viertel, A. Kunin, P. Duinker, M. MacDermott, Z. W. Yin, S. N. Ganguli, H. van der Graaf, C. Rippich, B. L. Betev, A. Degré, Giovanni Paternoster, J. Bao, U. Uwer, D. Kaplan, A. Contin, Alexander Savin, G. Morand, M. Elkacimi, P. Extermann, I. Leedom, H. Hofer, K. L. Tung, R. Morand, Z. L. Xue, Howard A. Stone, D. Pandoulas, J. Salicio, T.S. Dai, Y. H. Chang, George Alverson, T. Spickermann, S. Kwan, Ren-Yuan Zhu, Luciano Barone, Vineet Kumar, M. Guanziroli, R. Magahiz, G.G.G. Massaro, F. Carbonara, F.C. Erné, Q.Y. Yang, L. Martinez, A. Gurtu, F. L. Linde, V. Commichau, A. Böhm, G. Coignet, E. Shumilov, J. Zoll, M. Bocciolini, J. H. Field, M. Schöntag, W. Böhlen, V. Shoutko, Luciano Romero, C. F. He, Giorgio Gratta, A. Pevsner, M. Tonutti, Barry Blumenfeld, L. Antonov, A. Marchionni, V.R. Krastev, E. Gonzalez, B. Ille, S. Lanzano, Bernardo Adeva, R. W. Kraemer, V. Khoze, C-Q. Li, R. Bizzarri, S. Hancke, F. DeNotaristefani, P. Berges, M. Maire, L. Li, D. Boutigny, J.F. Li, H. Suter, Y.F. Wang, U. Micke, D. Linnhofer, R. Mount, W.D. Nowak, J. Berdugo, B. Monteleoni, W. Kittel, G. Chiefari, S. Shevchenko, M. Schneegans, R. Schulte, Zhuoxiang Ren, J. M. You, N. Produit, A. A. Syed, K. Lanius, F. Crijns, Marcel Merk, J. Perrier, C. Zabounidis, D. Goujon, Bz Yang, A. Sopczak, X. Leytens, H. Anderhub, C. Dionisi, Alain Hervé, G. Mirabelli, A. Bay, D. Campana, Carlo Civinini, M. Maolinbay, X.G. Li, M. Aguilar-Benitez, I. Duran, P. F. Klok, Herwig Schopper, M. White, Petr Levchenko, F. Wittgenstein, E. Drago, L. Niessen, Z.Y. Lin, T. Driever, M. Harris, E. Dénes, B. P. Roe, W.G. Ma, E. Nagy, M. Vivargent, Christine Buisson, Z. M. Wang, A. Arefiev, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), L3, IHEF (IoP, FNWI), B., Adeva, O., Adriani, M., Aguilarbenitez, H., Akbari, J., Alcaraz, Aloisio, Alberto, G., Alverson, Alviggi, Mariagrazia, Q., An, H., Anderhub, A. L., Anderson, V. P., Andreev, T., Angelov, L., Antonov, D., Antreasyan, A., Arefiev, T., Azemoon, T., Aziz, P. V., K., P., Bagnaia, J. A., Bakken, L., Baksay, R. C., Ball, S., Banerjee, J., Bao, L., Barone, A., Bay, U., Becker, S., Beingessner, G. L., Bencze, J., Berdugo, P., Berge, B., Bertucci, B. L., Betev, A., Biland, R., Bizzarri, J. J., Blaising, P., Blomeke, B., Blumenfeld, G. J., Bobbink, M., Bocciolini, W., Bohlen, A., Bohm, T., Bohringer, B., Borgia, D., Bourilkov, M., Bourquin, D., Boutigny, J. G., Branson, I. C., Brock, F., Bruyant, C., Buisson, J. D., Burger, J. P., Burq, X. D., Cai, D., Campana, C., Camp, M., Capell, F., Carbonara, F., Carminati, A. M., Cartacci, M., Cerrada, F., Cesaroni, Y. H., Chang, U. K., Chaturvedi, M., Chemarin, A., Chen, C., Chen, G. M., Chen, H. F., Chen, H. S., Chen, M., Chen, M. L., Chen, Chiefari, Giovanni, C. Y., Chien, C., Civinini, I., Clare, R., Clare, G., Coignet, N., Colino, V., Commichau, G., Conforto, A., Contin, F., Crijn, X. Y., Cui, T. S., Dai, R., Dalessandro, A., Degre, K., Deiter, E., Dene, P., Dene, F., Denotaristefani, M., Dhina, M., Diemoz, H. R., Dimitrov, C., Dionisi, F., Dittu, R., Dolin, E., Drago, T., Driever, P., Duinker, I., Duran, M., Elkacimi, A., Engler, F. J., Eppling, F. C., Erne, P., Extermann, R., Fabbretti, G., Faber, S., Falciano, S. J., Fan, M., Fabre, J., Fay, J., Fehlmann, H., Fenker, T., Ferguson, G., Fernandez, F., Ferroni, H., Fesefeldt, J., Field, G., Forconi, T., Foreman, K., Freudenreich, W., Friebel, M., Fukushima, M., Gailloud, Y., Galaktionov, E., Gallo, S. N., Ganguli, S. S., Gau, S., Gentile, M., Gettner, M., Glaubman, S., Goldfarb, Z. F., Gong, E., Gonzalez, A., Gordeev, P., Gottlicher, D., Goujon, C., Goy, G., Gratta, A., Grime, C., Grinnell, M., Gruenewald, M., Guanziroli, A., Gurtu, D., Gusewell, H., Haan, S., Hancke, K., Hangarter, M., Harri, D., Harting, F. G., Hartje, C. F., He, A., Heavey, T., Hebbeker, M., Hebert, G., Herten, U., Herten, A., Herve, K., Hilger, H., Hofer, L. S., Hsu, G., Hu, G. Q., Hu, B., Ille, M. M., Ilya, V., Innocente, E., Isiksal, E., Jagel, B. N., Jin, L. W., Jone, P., Kaaret, R. A., Khan, Y., Kamyshkov, D., Kaplan, Y., Karyotaki, V., Khoze, D., Kirkby, W., Kittel, A., Klimentov, P. F., Klok, A. C., Konig, O., Kornadt, V., Koutsenko, R. W., Kraemer, T., Kramer, V. R., Krastev, W., Krenz, A., Kuhn, V., Kumar, A., Kunin, S., Kwan, A., Vanlaak, V., Lalieu, G., Landi, K., Laniu, D., Lanske, S., Lanzano, P., Lebrun, P., Lecomte, P., Lecoq, P., Lecoultre, I., Leedom, J. M., Legoff, L., Leistam, R., Leiste, J., Lettry, P. M., Levchenko, X., Leyten, C., Li, H. T., Li, J. F., Li, L., Li, P. J., Li, X. G., Li, J. Y., Liao, R., Liu, Y., Liu, Z. Y., Lin, F. L., Linde, D., Linnhofer, W., Lohmann, S., Loko, E., Longo, Y. S., Lu, J. M., Lubber, K., Lubelsmeyer, C., Luci, D., Luckey, L., Ludovici, X., Lue, L., Luminari, W. G., Ma, M., Macdermott, R., Magahiz, M., Maire, P. K., Malhotra, A., Malinin, C., Mana, D. N., Mao, Y. F., Mao, M., Maolinbay, P., Marchesini, A., Marchionni, J. P., Martin, L., Martinez, F., Marzano, G. G., G., T., Matsuda, K., Mazumdar, P., Mcbride, T., Meinholz, M., Merk, Merola, Leonardo, M., Meschini, W. J., Metzger, Y., Mi, M., Micke, U., Micke, G. B., Mill, Y., Mir, G., Mirabelli, J., Mnich, L., Montanet, B., Monteleoni, G., Morand, R., Morand, S., Morganti, V., Morgunov, R., Mount, E., Nagy, Napolitano, Marco, H., Newman, L., Niessen, W. D., Nowak, J., Onvlee, D., Pandoula, Paternoster, Giovanni, Patricelli, Sergio, Y. J., Pei, Y., Peng, D., Perretgallix, J., Perrier, E., Perrin, A., Pevsner, M., Pieri, P. A., Piroue, V., Plyaskin, M., Pohl, V., Pojidaev, C. L., A., N., Produit, J. M., Qian, K. N., Qureshi, R., Raghavan, G., Rahalcallot, J., Vonrango, P., Razi, K., Read, D., Ren, Z., Ren, S., Reucroft, T., Riemann, C., Rippich, S., Rodriguez, B. P., Roe, M., Rohner, T., Rombach, L., Romero, J., Rose, S., Rosierlee, P., Rosselet, J. A., Rubio, W., Ruckstuhl, H., Rykaczewski, M., Sachwitz, J., Salicio, G., Sauvage, A., Savin, V., Schegelsky, P., Schmitt, D., Schmitz, P., Schmitz, M., Schneegan, M., Schontag, H., Schopper, D. J., Schotanu, H. J., Schreiber, R., Schulte, S., Schulte, K., Schultze, J., Schutte, J., Schwenke, G., Schwering, Sciacca, Crisostomo, P. G., Seiler, J. C., Sen, I., Sheer, V., Shevchenko, S., Shevchenko, X. R., Shi, K., Shmakov, V., Shoutko, E., Shumilov, N., Smirnov, A., Sopczak, C., Souyri, T., Spickermann, B., Spie, P., Spillantini, R., Starosta, M., Steuer, D. P., Stickland, B., Stohr, H., Stone, K., Strauch, K., Sudhakar, G., Sultanov, R. L., Sumner, H., Suter, R. B., Sutton, A. A., Syed, X. W., Tang, E., Tarkovsky, J. M., Thenard, E., Thoma, C., Timmerman, S. C., C., S. M., Ting, Y. P., Tong, M., Tonutti, S. C., Tonwar, J., Toth, K. L., Tung, J., Ulbricht, L., Urban, U., Uwer, E., Valente, R. T., Vandewalle, H., Vandergraaf, I., Vetlitsky, G., Viertel, P., Vika, M., Vivargent, H., Vogel, H., Vogt, M., Vollmar, G., Vondardel, I., Vorobiev, A. A., Vorobyov, A., Vorobyov, L., Vuilleumier, W., Walk, W., Wallraff, C. R., Wang, G. H., Wang, J. H., Wang, Q. F., Wang, X. L., Wang, Y. F., Wang, Z. M., Wang, J., Weber, R., Weill, T. J., Wenau, J., Wenninger, M., White, R., Wilhelm, C., Willmott, F., Wittgenstein, D., Wright, R. J., Wu, S. L., Wu, S. X., Wu, Y. G., Wu, B., Wyslouch, Z. Z., Xu, Z. L., Xue, D. S., Yan, B. Z., Yang, C. G., Yang, G., Yang, K. S., Yang, Q. Y., Yang, Z. Q., Yang, Q., Ye, C. H., Ye, S. C., Yeh, Z. W., Yin, J. M., You, C., Zabounidi, L., Zehnder, M., Zeng, Y., Zeng, D., Zhang, D. H., Zhang, S. Y., Zhang, Z. P., Zhang, J. F., Zhou, R. Y., Zhu, A., Zichichi, and J., Zoll
Subjects: Physics, Coupling constant, Nuclear and High Energy Physics, Particle physics, 010308 nuclear & particles physics, media_common.quotation_subject, Electron–positron annihilation, Detector, Charge (physics), 01 natural sciences, Asymmetry, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Atomic physics, 010306 general physics, Pseudovector, Particle Physics - Experiment, media_common, Lepton
Abstract: We have measured the partial widths of the Z 0 into lepton pairs, and the forward-backward charge asymmetry for the process e + e − → μ + μ − using the L3 detector at LEP. We obtain an average Γ ll of 83.0±2.1±1.1 MeV.From this result and the asymmetry measurement, we extract the values of the vector and axial vector couplings of the Z 0 to leptons: g rmv =−0.066 −0.027 +0.046 and g rmA = −0.495 −0.007 +0.007 .
Published: 1990

35. Measurements of the 90,91,92,94,96 Zr n, gamma cross-sections at n_TOF

Author: G. Cortes, Roberto Capote, P. Cennini, A. J. M. Plompen, G. Rudolf, I. Lopes, C. Pretel, G. Vannini, M. Mosconi, P. Pavlopoulos, A. Pavlik, James L. Cox, C. Stephan, S. O'Brien, C. Domingo-Pardo, S. David, R. Gallino, R. Terlizzi, G. Tagliente, F. Voss, J. Andrzejewski, Michael Heil, F. Käppeler, E. Griesmayer, V. Ketlerov, A. Molina-Coballes, L. Ferrant, L. Tavora, W. Rapp, Rene Reifarth, José M. Martínez-Val, J. Pancin, G. Aerts, J. Salgado, M. C. Vincente, A. Poch, A. Herrera-Martinez, Arnaud Ferrari, Nicola Colonna, P. Rullhusen, Corrie S. Moreau, L. Perrot, Alberto Mengoni, J.C. Soares, I. Duran, José Manuel Perlado, Heinz Oberhummer, Thomas Rauscher, Vasilis Vlachoudis, H. Alvarez-Pol, M. Dahlfors, J. M. Quesada, V. Chepel, L. Tassan-Got, V. Konovalov, Y. Kadi, D. Karadimos, P. Baumann, H. Frais-Koelbl, S. Isaev, U. Abbondanno, D. Cano-Ott, W.I. Furman, A.J.P.L. Policarpo, P. Vaz, Aaron Couture, S. Lukic, G. Lorusso, B. Haas, E. Gonzalez-Romero, E. Berthoumieux, P. E. Koehler, Enrico Chiaveri, M. Rosetti, Ralf Plag, J. Benlliure, F. Gramegna, A. Plukis, C. Lamboudis, J. L. Tain, R. C. Haight, M. Kerveno, C. Paradela, M. Krtička, A. Ventura, Saed Dababneh, Michael Wiescher, J. Marganiec, S. Andriamonje, D. Villamarin, P. F. Mastinu, Marco Pignatari, M. Embid-Segura, D. Cortina, Manuel Lozano, C. Rubbia, Isabel S. Gonçalves, S. Marrone, E. Jericha, K. Wisshak, H. Wendler, F. Gunsing, F. Neves, F. Calviño, H. Leeb, P. M. Milazzo, R. Ferreira-Marques, T. Papaevangelou, F. Bečvář, A. Lindote, A. Goverdovski, F. Alvarez-Velarde, Gerald Badurek, R. Dolfini, L. Buchmann, M. Comyn, J. Thomson, Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), nTOF, Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya. GREENER - Grup de recerca d'estudis energètics i de les radiacions, G. Tagliente, U. Abbondanno, G. Aert, F. Alvarez-Velarde, H. Alvarez-Pol, S. Andriamonje, J. Andrzejewski, G. Badurek, P. Baumann, F. Becvar, J. Benlliure, E. Berthoumieux, F. Calvino, D. Cano-Ott, R. Capote, P. Cennini, V. Chepel, E. Chiaveri, N. Colonna, G. Corte, D. Cortina, A. Couture, J. Cox, S. Dababneh, M. Dahlfor, S. David, R. Dolfini, C. Domingo-Pardo, I. Duran, M. Embid-Segura, L. Ferrant, A. Ferrari, R. Ferrera-Marque, H. Frais-Koelbl, W. Furman, I. Goncalve, R. Gallino, E. Gonzalez-Romero, A. Goverdoski, F. Gramegna, E. Griesmayer, F. Gunsing, B. Haa, R. Haight, M. Heil, A. Herrera-Martinez, S. Isaev, E. Jericha, F. Kaeppeler, Y. Kadi, D. Karadimo, M. Kerveno, V. Ketlerov, P. Koehler, V. Konovalov, M. Krticka, C. Lamboudi, H. Leeb, A. Lindote, I. Lope, G. Lorusso, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, J. Martinez-Val, P. Mastinu, A. Mengoni, P.M. Milazzo, A. Molina-Coballe, C. Moreau, M. Mosconi, F. Neve, H. Oberhummer, S. O'Brien, J. Pancin, T. Papaevangelou, C. Paradela, A. Pavlik, P. Pavlopoulo, J.M. Perlado, L. Perrot, M. Pignatari, R. Plag, A. Plompen, A. Pluki, A. Poch, A. Policarpo, C. Pretel, J. Quesada, W. Rapp, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, I.C. Soare, C. Stephan, J.L. Tain, L. Tassan-Got, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, M.C. Vincente, V. Vlachoudi, F. Vo, H. Wendler, M. Wiescher, and K. Wisshak
Subjects: Nuclear and High Energy Physics, Neutron cross sections, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, Neutron scattering, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Neutrons -- Seccions, Neutron time-of-flight scattering, Nuclear physics, 0103 physical sciences, Neutron cross section, Neutrons -- Mesurament, Neutron, 010306 general physics, Nuclear Experiment, Physics, Bonner sphere, 010308 nuclear & particles physics, Neutrons--Measurement, Neutron stimulated emission computed tomography, Neutron temperature, Neutron capture, Física::Astronomia i astrofísica [Àrees temàtiques de la UPC], Physics::Accelerator Physics
Abstract: Neutron capture cross sections of the 90,91,92,94,96Zr have been measured over the energy range from 1 eV to 1 MeV at the spallation neutron facility n TOF at CERN in 2003. The innovative features of the neutron beam, in particular the high instantaneous flux, the high energy resolution and low background, together with improvements of the neutron sensitivity of the capture detectors make this facility unique for neutron-induced reaction cross section measurements with much improved accuracy. The preliminary results of the Zr measurements show capture resonance strengths generally smaller than in previous measurements.
Published: 2005

36. Trifaroteno: un nuevo protagonista en el panorama retinoide

Author: A. Guerra-Tapia and E. González-Guerra
Subjects: Dermatology, RL1-803, Internal medicine, RC31-1245
Published: 2021
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37. Volumetric measurement of the hippocampus in a series of patients with Alzheimer disease

Author: A. Viña-González, I. Rodriguez Gil, S. Sosa Pérez, N. Urrutia Amable, L. Pérez Ruiz, T. Rodríguez Obaya, and E. González Dalmau
Subjects: Biomarcador imagenológico, Enfermedad de Alzheimer, FreeSurfer, Hipocampo, Indice de asimetría, IRM, Neurology. Diseases of the nervous system, RC346-429
Abstract: Background: Hippocampal volume is recognised as a surrogate imaging biomarker for the study of Alzheimer's disease (AD). However, in Cuba there are no antecedents of its use. The objective of this research was to establish an automatic hippocampal segmentation procedure to study a sample of Cuban subjects diagnosed with possible mild or moderate AD. Methodology: A total of 104 subjects with mean ages of 73.77 ± 6.74 years participated. Imaging for the calculation of hippocampal volumes and asymmetry index (AI) was performed with a Siemens Magnetom Allegra 3T scanner using an MP-RAGE sequence. Volumes were obtained manually and automatically using Amira 5.3 and FreeSurfer 6.0 software, respectively. The results of both methods were statistically compared. Results: The steps for hippocampal volumetric quantification were established for these methods. Comparison between them showed high concordance (ICC = 0.95) for both hippocampi. Therefore, there were no significant differences between them. The mean right (2961.84 ± 552.70 mm3) and left (2892.68 ± 536.6 mm3) volumes of the subjects were obtained. These volumes and the asymmetry index were significantly different with respect to a sample of healthy subjects with (p = 0.00001) and (p = 0.003) respectively; and similar to those obtained in a sample of subjects with AD in Latin America. Conclusions: A procedure for automated volumetric quantification of the hippocampus was established. This allowed the study of a Cuban sample with possible AD. This constitutes a previous step to longitudinally evaluate the effectiveness of new Cuban drugs. Resumen: Introducción: El volumen del hipocampo es reconocido como un biomarcador imagenológico subrogado para el estudio de la Enfermedad de Alzheimer (EA). Sin embargo, en Cuba no hay antecedentes de su uso. El objetivo de esta investigación fue establecer un procedimiento de segmentación automática del hipocampo para estudiar una muestra de sujetos cubanos diagnósticados con posible EA leve o moderada. Métodos: Participaron 104 sujetos con edades promedio de 73.77 ± 6.74 años. Las imágenes utilizadas para el cálculo de los volúmenes hipocampales y el índice de asimetría (IA) se realizó con un escáner Siemens Magnetom Allegra 3T usando una secuencia MP-RAGE. La obtención de los volúmenes se hizo de forma manual y automática usando el programa Amira 5.3 y FreeSurfer 6.0 respectivamente. Se compararon estadísticamente los resultados de ambos métodos. Resultados: Se establecieron los pasos para la cuantificación volumétrica del hipocampo para estos métodos. La comparación entre ellos mostró alta concordancia (CCI = 0.95) para ambos hipocampos. Por tanto, no existieron diferencias significativas entre ellos. Se obtuvieron los volúmenes medios derecho (2961.84 ± 552.70 mm3) e izquierdo (2892.68 ± 536.6 mm3) de los sujetos. Estos volúmenes y el índice se asimetría fueron significativamente diferentes respecto una muestra de sujetos sanos con (p = 0.00001) y (p = 0.003) respectivamente; y similares a los obtenidos en una muestra de sujetos con EA en América Latina. Conclusiones: Quedó establecido un procedimiento para la cuantificación volumétrica automatizada del hipocampo. Esto permitió el estudio de una muestra cubana con posible EA. Constituyendo un paso previo para evaluar longitudinalmente la efectividad de nuevos medicamentos cubanos.
Published: 2021
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38. A study of four fermion processes at LEP

Author: P. Marchesini, M. MacDermott, M. A. Niaz, T. Angelescu, R. Malik, G. Landi, S. X. Wu, Simone Paoletti, Manjit Kaur, Ming Zeng, X. R. Shi, Daqiang Zhang, H. Anderhub, W. van Rossum, P. Extermann, J. Busenitz, J. M. Lubbers, M. Caria, Felicitas Pauss, L. Romero, Raffaello D'Alessandro, D. DiBitonto, M. Röhner, S. Rosier-Lees, R. Barillère, Christoph Schäfer, I. Leedom, B. Z. Yang, H. Hofer, K. L. Tung, Yu. Kamyshkov, Adrian Biland, A. Koulbardis, Ph. Rosselet, Wt Lin, D.W. Schmitz, G. Pascale, G.G.G. Massaro, C. Leggett, Claudio Luci, M. Guanziroli, Robert Clare, Leonardo Merola, W. G. Ma, Thomas Hebbeker, Paul Lecoq, R. W. Kraemer, M. Napolitano, I. Josa-Mutuberria, P. Le Coultre, H. S. Chen, J. G. Xu, L. Servoli, S. J. Fan, M. Fukushima, G.B. Mills, Maurizio Biasini, L. Urbán, Giovanni Ambrosi, M. Bourquin, S. Röhner, F. Wittgenstein, Zhuoxiang Ren, Y. J. Pei, Roberto Battiston, D. J. Schotanus, J. P. Martin, F. Ferroni, I. Vorobiev, Y. Zeng, J. M. You, L. Ludovici, M. Steuer, G. Forconi, J. Weber, K. Hangarter, C. G. Yang, Peter Denes, Paolo Bagnaia, K. Strauch, M. Lenti, Stefan Roth, E. Drago, T. Azemoon, R. T. Van de Walle, V. Koutsenko, A. Nadtochy, Egidio Longo, P. Zemp, R. de Asmundis, V. R. Krastev, Marta Felcini, K. Banicz, J. K. Kim, R. Starosta, D. Perret-Gallix, D. Luckey, W. Lu, Steven Ahlen, E. Shumilov, A. Marin, G. M. Bilei, Gy L. Bencze, G. A. Yang, A. C. Weber, A. Engler, M. M. Ilyas, V. Shoutko, J. M. Le Goff, B. C. Riemers, Reinhard W. Schulte, K. S. Kumar, D. H. Wright, N. Gheordanescu, M. Capell, D. Boutigny, W. Kittel, A. Arefiev, A. Adam, T. Paul, Francesco Becattini, I. Scott, Marcos Cerrada, S. C. Tonwar, Andrea Contin, J. C. Sens, G. S. Sanders, Andre Sopczak, Gerard Fernandez, M. Tonutti, P. G. Seiler, J. A. Rubio, H. S. Fesefeldt, Y. Mi, R. Fabbretti, Gerjan Bobbink, B. Borgia, H. R. Dimitrov, M. T. Choi, Frank Filthaut, M. Möller, O. Fackler, R. Weill, Francesca Nessi-Tedaldi, K. N. Qureshi, W. Friebel, F. Cesaroni, J. Y. Liao, Thomas Ferguson, Axel König, M. Hebert, E. Valente, M. Wadhwa, Panos A Razis, Jozsef Toth, A. L. Anderson, F. Marion, J. D. Burger, H. F. Chen, A. Buytenhuijs, A. Gougas, Bolek Wyslouch, J. Ulbricht, Georgi Sultanov, T. S. Dai, G. Mirabelli, Yu. Galaktionov, Emilio Leonardi, G. Rahal-Callot, J. F. Zhou, R. A. Khan, B. P. Roe, C. Wang, J. Alcaraz, D. McNally, E. Gonzalez, S. Patricelli, Stefan Kirsch, Marco Meschini, Elisabetta Gallo, R. Bock, O. Toker, A. Lebedev, D. Kirkby, K. Riles, Dong-Chul Son, T. Kramer, E. Dénes, R. Sehgal, Pierluigi Paolucci, H. El Mamouni, J. J. Blaising, Chenjie Gu, Q. Ye, Chenliang Wang, J. Berdugo, F. Cotorobai, Stefano Giagu, P. Schmitz, K. Lübelsmeyer, Piero Spillantini, M. Gailloud, P. Arce, G. Schwering, G. Viertel, I. Clare, F. J. Rodriguez, F. Marzano, G. Coignet, W. Krenz, V. P. Andreev, H. R. Gustafson, Christopher George Tully, G. Chiefari, D. Z. Shen, S. Shevchenko, S. Reucroft, E. Nagy, F. Plasil, Mariagrazia Alviggi, C. F. He, D. Goujon, K. Schultze, H. Suter, J. M. Ma, Mingshui Chen, Luca Lista, S. Shotkin, K. Freudenreich, Helmut Vogel, M. Chemarin, J. A. Bakken, M. Sassowsky, Wolfgang Lohmann, H. Vogt, B. Bertucci, Samuel C.C. Ting, G. F. Susinno, Cheng Chen, A. Mihul, S. C. Kim, M. Pauluzzi, S. Morganti, A. Bujak, Oliver Kornadt, M. Pohl, F. Behner, G. M. Chen, Vincenzo Innocente, L. Fredj, J. Schwenke, F. C. Erné, Nicanor Colino, M. L. Brooks, I. Vetlitsky, D. Lanske, W. J. Burger, Andrea Baschirotto, C. Zaccardelli, D. Fernandez, Kajari Mazumdar, D. Ren, X. Y. Cui, Yuehong Xie, Roberto Castello, A. Kasser, Y. F. Wang, R. Leiste, P. Vikas, S. Costantini, L. Martinez-Laso, Christoph Paus, G. Passaleva, J. Shukla, G. Tsipolitis, A. A. Vorobyoy, S. Khokhar, T.R. McMahon, S. Müller, A. A. Syed, W. W. Kinnison, S. C. Yeh, U. Vikas, Guofan Hu, L. J. Gutay, Z. M. Wang, A. Atamanchuk, M. S. Sarakinos, S. Lanzano, Yanwen Liu, M. Rescigno, C. Maña, O. Adriani, U. Becker, I. C. Brock, D. Gele, Xd Cai, M. Bosetti, C. Dionisi, B. Monteleoni, T. E. Coan, J. G. Branson, F. Sticozzi, A. Pevsner, Pablo Garcia-Abia, K. Sudhakar, Lucas Taylor, Lamberto Luminari, S. Easo, Alain Hervé, Davide Piccolo, I. Duran, Z. W. Yin, J. S. Lee, S. N. Ganguli, V. Plyaskin, M. Fabre, M. Schneegans, D. M. Lee, M. Yzerman, A. Bay, Sabine Riemann, S. Wynhoff, C-Q. Li, A. Degré, J. B. Ye, Carlo Civinini, Marcella Diemoz, R. Morand, Z. L. Xue, O. Rind, M. Maolinbay, G. Raven, F. J. Eppling, G. J. Zhou, L. W. Jones, Howard A. Stone, M. Rattaggi, M. T. Dova, M. Aguilar-Benitez, J. Mnich, R. C. Ball, Herwig Schopper, Y. G. Kim, V. K. Gupta, Jun Guo, Pierre Lecomte, D. P. Stickland, G. Sartorelli, B. Lindemann, H. Postema, M. White, Y. H. Chang, D. S. Yan, H. O. Cohn, L. Antonov, George Alverson, S. M. Ting, A. Rubbia, Werner Lustermann, Y. Mir, C. H. Ye, J. S. Kapustinsky, D. Pandoulas, Marcel Merk, X. T. Cui, S. Ro, T. Spickermann, J. Perrier, A. Krivshich, Michael Dittmar, Bernard Ille, J. D. Swain, P. McBride, R. Bizzarri, J. Bao, H. A. Rizvi, Gianpaolo Carlino, F. DeNotaristefani, A. Böhm, A. Kunin, J. M. Salicio, Hafeez R Hoorani, W. Y. Chen, W. J. Metzger, S. Goldfarb, J. T. He, F. L. Linde, S. Pensotti, Valery Schegelsky, Antonino Zichichi, Ph Fisher, H. Rykaczewski, Giovanni Organtini, Y. Karyotakis, S. Chung, P.V.K.S. Baba, Attilio Santocchia, Jean Fay, M. Dhina, Z. Y. Lin, N. Yunus, P. Berges, R. Mount, B. L. Betev, Ren-Yuan Zhu, Luciano Barone, A. Nippe, G. Gratta, D. Duchesneau, Alexander Malinin, X. L. Wang, A. Gurtu, A. M. Cartacci, R. Raghavan, Els Koffeman, H. J. Schreiber, Laurent Vuilleumier, Z. F. Gong, E. Brambilla, Z. Z. Xu, J. Wenninger, V. Pojidaev, A. Hasan, H. Kuijten, M. N. Kienzle-Focacci, R. Rosmalen, J. Behrens, V. Soulimov, A. Tsaregorodtsev, P. J. Li, K. Y. Lee, P. Lebrun, BT Bouwens, Guo-Ming Chen, U. Uwer, A. Chen, J. Salicio, M. Gruenewald, U. K. Chaturvedi, Y. S. Lu, J. H. Field, C. Y. Chien, A. Kirkby, Dimitri Bourilkov, N. E. Moulai, E. Fiandrini, Luca Malgeri, G. Sauvage, Z. D. Qi, Harvey B Newman, K. Hilgers, L. Djambazov, Konrad Deiters, M. Vivargent, M. Sachwitz, Alberto Aloisio, A. Ricker, X. W. Tang, I. Sheer, P. A. Piroué, B. Zhou, B. C.C. van der Zwaan, Tariq Aziz, Crisostomo Sciacca, Marco Pieri, C. Neyer, P. G. Rancoita, B. N. Jin, H. Nowak, W. Wallraff, T. J. Wenaus, S. Banerjee, Zp Zhang, G. Terzi, D. Antreasyan, Qi An, P. Kapinos, P. Duinker, Simonetta Gentile, A. Klimentov, H. Janssen, Kenneth Francis Read, L. Z. Sun, D. Hauschildt, Jianming Qian, G. Hu, Carlos Willmott, Speranza Falciano, H. T. Li, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), L3, and IHEF (IoP, FNWI)
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), 010308 nuclear & particles physics, Electron–positron annihilation, Monte Carlo method, Elementary particle, Fermion, 01 natural sciences, Standard Model, Nuclear physics, Recoil, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, 010306 general physics, Particle Physics - Experiment, Bhabha scattering
Abstract: We have studied the four-fermion processes ee → eeee, eeμμ, eeττ, μμμμ, μμττ, eeqq and μμqq with the L3 detector at LEP. For an integrated luminosity of 36 pb-, corresponding to 960 000 hadronic Z decays, we find a total of 67 candidate events. The rate and kinematical distributions are found to be consistent with first order Monte Carlo calculations based on the Standard Model. No significant structure is seen in the dilepton invariant or recoil mass spectra. © 1994.
Published: 1994

39. Determination of the effective electroweak mixing angle from Z decays

Author: R. Fabbretti, H. Anderhub, Lamberto Luminari, Luca Lista, D. Fernandez, Yanwen Liu, S. Pensotti, Valery Schegelsky, E. Dénes, R. Sehgal, Sabine Riemann, Ren-Yuan Zhu, Luciano Barone, F. C. Erné, B. P. Roe, C. Wang, M. MacDermott, R. Weill, Ph Fisher, R. C. Ball, H. Rykaczewski, Giovanni Organtini, G. Sartorelli, Y. Karyotakis, A. L. Anderson, M. A. Niaz, F. Marion, J. F. Zhou, K. Mazumdar, Roberto Castello, Yu. Kamyshkov, P. Extermann, S. Chung, P.V.K.S. Baba, Attilio Santocchia, Jean Fay, Dimitri Bourilkov, C. Neyer, P. Lecomte, I. Leedom, B. Z. Yang, P. Vikas, R. Barillère, M. Dhina, D. Boutigny, Marco Meschini, H. Hofer, C. Warner, A. Arefiev, K. L. Tung, G. B. Mills, A. Lebedev, G. Tsipolitis, R. Klöckner, D. Kirkby, A. Gurtu, P. G. Rancoita, Els Koffeman, H. J. Schreiber, Werner Lustermann, C. G. Yang, B. N. Jin, H. Nowak, A. Krivshich, Steven Ahlen, N. E. Moulai, P. Schmitz, Z. Y. Lin, L. Antonov, T. Kraemer, E. Fiandrini, Dong-Chul Son, J. J. Blaising, Egidio Longo, Y. J. Pei, P. Zemp, J. Bechtluft, R. de Asmundis, K. S. Kumar, E. Brambilla, B. Hartmann, Christopher George Tully, M. M. Ilyas, Roberto Battiston, A. Hasan, P. K. Malhotra, H. A. Rizvi, A. Kunin, G. Herten, A. Bujak, Oliver Kornadt, M. Pohl, Hafeez R Hoorani, Yuehong Xie, F. Fesefeldt, S. Khokhar, S. Müller, K. Freudenreich, J. M. Salicio, K. Sudhakar, D. Pandoulas, T. Spickermann, W. Wallraff, Wolfgang Lohmann, H. Vogt, B. Bertucci, Y. F. Wang, W. Friebel, C-Q. Li, B. L. Betev, S. C. Kim, S. Banerjee, Gerjan Bobbink, W. J. Metzger, M. Caria, V. K. Gupta, Zp Zhang, B. Borgia, G. Sauvage, M. Wadhwa, Z. D. Qi, Xd Cai, Nicanor Colino, Bernard Ille, Z. M. Wang, K. Riles, M. Gruenewald, J. T. He, Tariq Aziz, J. B. Ye, Stefan Kirsch, F. Cesaroni, F. J. Rodriguez, G. Schwering, Pierluigi Paolucci, M. Gailloud, M. Möller, J. Y. Liao, Raffaello D'Alessandro, O. Rind, F. Marzano, G. Coignet, W. Krenz, R. Bizzarri, G. F. Susinno, A. M. Cartacci, R. Raghavan, T. McHamon, A. C. König, Mariagrazia Alviggi, H. R. Gustafson, D. Z. Shen, J. A. Bakken, F. L. Linde, J. Ulbricht, R. Mount, U. K. Chaturvedi, Laurent Vuilleumier, Y. S. Lu, Gianpaolo Carlino, F. DeNotaristefani, M. Sassowsky, J. D. Swain, D. Antreasyan, A. Koulbardis, Harvey B Newman, K. Hilgers, R. Becker, An.A. Vorobyov, M. T. Choi, Emilio Leonardi, S. X. Wu, C. Maña, I. C. Brock, F. Wittgenstein, P. McBride, Leonardo Merola, Giovanni Ambrosi, L. Ludovici, J. H. Field, Crisostomo Sciacca, Marco Pieri, C. Y. Chien, O. Adriani, R. Bock, Francesca Nessi-Tedaldi, Gerard Fernandez, H. Suter, S. Easo, G. H. Wang, I. Vetlitsky, D. DiBitonto, Z. Z. Xu, J. Wenninger, I. Clare, J. Busenitz, V. Plyaskin, Ph. Rosselet, L. Djambazov, M. Vivargent, M. Sachwitz, A. Kirkby, Lucas Taylor, H. El Mamouni, V. Koutsenko, M. Steuer, G. Forconi, J. D. Burger, V. Pojidaev, W. van Rossum, Jozsef Toth, L. Baksay, J. Weber, E. Drago, David Stickland, A. Marin, P. J. Li, Konrad Deiters, Bolek Wyslouch, Chenjie Gu, A. Zichichi, Alberto Aloisio, A. Ricker, T. Azemoon, P. Lebrun, F. Plasil, H. F. Chen, A. Buytenhuijs, P. Arce, Z. F. Gong, Elisabetta Gallo, D. Goujon, P. Berges, M. T. Dova, D. Perret-Gallix, Adrian Biland, G. Rahal-Callot, J. M. Ma, A. Böhm, A. Pevsner, Qi An, BT Bouwens, T. Paul, Marcos Cerrada, H. R. Dimitrov, O. Fackler, X. R. Shi, Felicitas Pauss, Y. Mi, Samuel C.C. Ting, H. O. Cohn, S. C. Tonwar, Frank Filthaut, Thomas Ferguson, Mingshui Chen, S. Rosier-Lees, X. W. Tang, S. J. Fan, Chenliang Wang, Vincenzo Innocente, Maurizio Biasini, A. C. Weber, I. Sheer, L. Urbán, P. A. Piroué, B. Zhou, W. Kittel, P. Le Coultre, F. Ferroni, U. Uwer, Marta Felcini, J. G. Xu, B. C.C. van der Zwaan, Yu. Galaktionov, G. Passaleva, J. A. Rubio, K. Schultze, X. T. Cui, A. Chen, Y. Zeng, M. Fukushima, J. Salicio, M. Lenti, Stefan Roth, A. Kasser, Guofan Hu, Christoph Paus, D. Gele, J. Alcaraz, Elemer Nagy, M. Bosetti, A. Sopczak, D. Lanske, K. Hangarter, Pablo Garcia-Abia, Alain Hervé, A. 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R., Shumilov, E., Shoutko, V., Son, D., Sopczak, A., Spartiotis, C., Spickermann, T., Spillantini, P., Starosta, R., Steuer, M., Stickland, D. P., Sticozzi, F., Stone, H., Strauch, K., Stringfellow, B. C., Sudhakar, K., Sultanov, G., Sun, L. Z., Susinno, G. F., Suter, H., Swain, J. D., Syed, A. A., Tang, X. W., Taylor, L., Terzi, G., S. C. C., Ting, S. M., Tonutti, M., Tonwar, S. C., Toth, J., Tsaregorodtsev, A., Tsipolitis, G., Tully, C., Tung, K. L., Ulbricht, J., Urban, L., Uwer, U., Valente, E., Vandewalle, R. T., Vetlitsky, I., Viertel, G., Vikas, P., Vikas, U., Vivargent, M., Vogel, H., Vogt, H., Vorobiev, I., Vorobyov, A. A., Vuilleumier, L., Wadhwa, M., Wallraff, W., Wang, C., Wang, C. R., Wang, G. H., Wang, X. L., Wang, Y. F., Wang, Z. M., Warner, C., Weber, A., Weber, J., Weill, R., Wenaus, T. J., Wenninger, J., White, M., Willmott, C., Wittgenstein, F., Wright, D., S. X., Wu, Wynhoff, S., Wyslouch, B., Xie, Y. Y., J. G., Xu, Z. Z., Xu, Xue, Z. L., Yan, D. S., Yang, B. Z., Yang, C. G., Yang, G., C. H., Ye, J. B., Ye, Ye, Q., Yeh, S. C., Yin, Z. W., You, J. M., Yunus, N., Yzerman, M., Zaccardelli, C., Zemp, P., Zeng, M., Zheng, Y., Zhang, D. H., Zhang, Z. P., Zhou, B., Zhou, G. J., Zhou, J. F., Zhu, R. Y., Zichichi, A., B. C. C., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), L3, and IHEF (IoP, FNWI)
Subjects: Nuclear and High Energy Physics, Particle physics, Electron–positron annihilation, Hadron, Elementary particle, 7. Clean energy, 01 natural sciences, Standard Model, Nuclear physics, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 010306 general physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Ciencias Exactas, Mixing (physics), Physics, electroweak interaction, 010308 nuclear & particles physics, Electroweak interaction, High Energy Physics::Phenomenology, Física, z boson, Weinberg angle, lcsh:QC1-999, High Energy Physics::Experiment, Particle Physics - Experiment, lcsh:Physics, Lepton
Abstract: The effective electroweak mixing angle sin2θw is measured from the production and decay of the Z boson in e+e- interactions. The data sample corresponds to an integrated luminosity of 18 pb-l with about 420 000 hadronic and 40 000 leptonic Z decays. The mixing angle sin 22θw is determined from several independent measurements: the leptonic and hadronic cross sections, the forward-backward asymmetries of charged leptons and b-quarks, and the z-polarization. The results are found to be in good agreement with each other. The value of sin 22θw from a fit to the asymmetries in a model independent method is 0.2321-4-0.0021 and from a global fit to the data in the Standard Model framework is 0.2328±0.0013., Facultad de Ciencias Exactas
Published: 1993

40. Fatty acid synthase and in vitro adipogenic response of human adipocytes inhibited by α and α′ subunits of soybean β-conglycinin hydrolysates

Author: Cristina Martínez-Villaluenga, Maxine J. Roman, Neal A. Bringe, E. Gonzalez de Mejia, Monsanto Company, and European Commission
Subjects: chemistry.chemical_classification, biology, Protein subunit, Peptide, General Medicine, Hydrolysate, Analytical Chemistry, chemistry.chemical_compound, Fatty acid synthase, Enzyme, chemistry, Biochemistry, Adipogenesis, Adipocyte, biology.protein, Soy protein, Food Science
Abstract: The objective was to assess the effect of protein hydrolysates of β-conglycinin enriched soybean on fatty acid synthase (FAS) activity and adipogenic response of human adipocytes in vitro. The results showed that genotypic changes in soybean protein subunits produced peptide profiles that led to inhibition of FAS and lipid accumulation in vitro. FAS inhibitory potency (IC50) of soy protein hydrolysates (SPH) ranged from 50 to 175 μM, while lipid inhibition from 15.6% to 45.9%. Protein hydrolysate C2H from a soybean containing the highest total β-conglycinin (46.9%) showed the most potent inhibitory effect on in vitro adipogenesis (46%) and FAS (IC50 = 50 μM). C2H was composed of dominant peptides from fragments f(85–112) and f(131–132) of β-conglycinin α subunit. Smaller peptides identified as fragments f(330–342) and f(329–342) of α′ subunit were also found. In conclusion, soybean genotypes enriched in β-conglycinin α and α′ subunits are suitable sources of active peptides that inhibit FAS activity and lipid accumulation., This work was supported by the Monsanto Company and the European Commission under a Marie Curie International Outgoing Fellowship for Career Development (to M-V,C).1576E. Gonzalez de Mejia et al./Food Chemistry 119 (2010) 1571–1577
Published: 2010

41. Neutron cross-sections for next generation reactors: New data from n_TOF

Author: C. Eleftheriadis, Carlos Guerrero, S. David, L. Tavora, G. Cortes, Alfredo Ferrari, R. Ferreira-Marques, Heinz Oberhummer, G. Tagliente, Yacine Kadi, P. Rullhusen, A. Herrera-Martinez, N. Patronis, L. Perrot, K. Wisshak, D. Villamarin, W.I. Furman, Masayuki Igashira, A. J. M. Plompen, J. Marganiec, S. Andriamonje, V. Chepel, S. Walter, Ralf Plag, S. Lukic, Marco T. Pigni, G. Rudolf, I. Lopes, F. Neves, C. A. Papachristodoulou, P. M. Milazzo, P. Cennini, M. Oshima, H. Wendler, Roberto Capote, E. Kossionides, P. Baumann, P.A. Assimakopoulos, J. Andrzejewski, James L. Cox, J. Salgado, G. Aerts, E. Chiaveri, Carlo Rubbia, P. F. Mastinu, D. Cano-Ott, V. Vlachoudis, M. Mosconi, F. Voss, A. Poch, L. Sarchiapone, I. Duran, F. Becvar, E. Griesmayer, H. Leeb, I. Dillman, C. Stephan, S. O'Brien, A. Carrillo de Albornoz, R. Terlizzi, M. C. Vicente, Marco Calviani, V. Konovalov, F. Käppeler, Nicola Colonna, G. Vannini, Corrie S. Moreau, R. C. Haight, P. E. Koehler, D. Karamanis, E. Jericha, S. Isaev, U. Abbondanno, C. Paradela, F. Gunsing, L. Audouin, E. Gonzalez-Romero, R. Vlastou, Michael Wiescher, A. Plukis, Cristian Massimi, E. Berthoumieux, F. Gramegna, M. Krtička, F. Calviño, T. Martinez, A. Lindote, Rene Reifarth, I. Savvidis, J. M. Quesada, L. Tassan-Got, A. Goverdovski, F. Alvarez-Velarde, Gerald Badurek, R. Dolfini, L. Ferrant, A. Ventura, P. Pavlopoulos, C. Lampoudis, H. Álvarez, A. Pavlik, J. L. Tain, C. Domingo-Pardo, Martin Heil, H. Frais-Koelbl, Manuel Lozano, J. Pancin, B. Haas, M. Dahlfors, P. Vaz, Aaron Couture, C. T. Papadopoulos, W. Dridi, L. Marques, Isabel S. Gonçalves, S. Marrone, M. Kerveno, K. Fujii, Alberto Mengoni, V. Ketlerov, C. Pretel, M. Rosetti, Thomas Rauscher, D. Karadimos, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Pôle Universitaire Léonard de Vinci, Pôle Universitaire Léonard de Vinci (PULV), TOF, N. Colonna, U. Abbondanno, G. Aerts, H. Álvarez, F. Álvarez-Velarde, S. Andriamonje, J. Andrzejewski, P. Assimakopoulos, L. Audouin, G. Badurek, P. Baumann, F. Bečvář, F. Belloni, B. Berthier, E. Berthoumieux, M. Calviani, F. Calviño, D. Cano-Ott, R. Capote, C. Carrapiço, P. Cennini, V. Chepel, E. Chiaveri, G. Cortes, A. Couture, J. Cox, M. Dahlfors, S. David, I. Dillmann, C. Domingo-Pardo, W. Dridi, I. Duran, C. Eleftheriadis, M. Embid-Segura, L. Ferrant,†, A. Ferrari, R. Ferreira-Marques, K. Fujii, W. Furman, I. Goncalves, E. González-Romero, A. Goverdovski, F. Gramegna, E Griesmayer, C. Guerrero, F. Gunsing, B. Haas, R. Haight, M. Heil, A. Herrera-Martinez, M. Igashira, E. Jericha, F. Käppeler, Y. Kadi, D. Karadimos, D. Karamanis, V. Ketlerov, M. Kerveno, P. Koehler, V. Konovalov, E. Kossionides, M. Krtička, C. Lampoudis, H. Leeb, A. Lindote, I. Lopes, M. Lozano, S. Lukic, J. Marganiec, S. Marrone, T. Martínez, C. Massimi, P. Mastinu, A. Mengoni, P. M. Milazzo, C. Moreau, M. Mosconi, F. Neves, H. Oberhummer, S. O'Brien, J. Pancin, C. Papachristodoulou, C. Papadopoulos, C. Paradela, N. Patronis, A. Pavlik, P. Pavlopoulos, L. Perrot, M. T. Pigni, R. Plag, A. Plompen, A. Plukis, A. Poch, C. Pretel, J. Quesada, T. Rauscher, R. Reifarth, M. Rosetti, C. Rubbia, G. Rudolf, P. Rullhusen, J. Salgado, L. Sarchiapone, I. Savvidis, C. Stephan, G. Tagliente, J. L. Tain, L. Tassan-Got, L. Tavora, R. Terlizzi, G. Vannini, P. Vaz, A. Ventura, D. Villamarin, M. C. Vincente, V. Vlachoudis, R. Vlastou, F. Voss, S. Walter, M. Wiescher, K. Wisshak, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Fission, Nuclear Theory, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Sensitivity and Specificity, Nuclear physics, Data acquisition, Neutron flux, Nuclear Reactors, 0103 physical sciences, Nuclear astrophysics, Neutron, 010306 general physics, Nuclear Experiment, Physics, Neutrons, Radiation, Large Hadron Collider, 010308 nuclear & particles physics, Reproducibility of Results, Equipment Design, Neutron Capture Therapy, NUCLEAR FISSION, Equipment Failure Analysis, 13. Climate action, Nuclear fission, Spallation Neutron Source
Abstract: 7th International Topical Meeting on Industrial Radiation and Radioisotope Measurement Application. Czech Tech univ, Prague, CZECH REPUBLIC. JUN 22-27, 2008, In 2002, an innovative neutron time-of-flight facility started operation at CERN: n_TOF. The main characteristics that make the new facility unique are the high instantaneous neutron flux, high resolution and wide energy range. Combined with state-of-the-art detectors and data acquisition system, these features have allowed to collect high accuracy neutron cross-section data on a variety of isotopes, many of which radioactive, of interest for Nuclear Astrophysics and for applications to advanced reactor technologies. A review of the most important results on capture and fission reactions obtained so far at n_TOF is presented, together with plans for new measurements related to nuclear industry.
Published: 2010

42. An improved measurement of BO-BO mixing in ZO decays

Author: Yu. Kamyshkov, C. G. Yang, L.J. Gutay, Stefan Kirsch, K. S. Kumar, An.A. Vorobyov, T. Matsuda, O. Adriani, Lucas Taylor, M. G. Alviggi, J. Y. Liao, Emilio Leonardi, R. Bock, Yu. Galaktionov, J. Alcaraz, Bao Yang, A. M. Cartacci, R. Raghavan, A. C. König, Laurent Vuilleumier, R.B. Sutton, M. Guanziroli, S. Falciano, V. Pojidaev, M. Fukushima, M. Lenti, Giovanni Ambrosi, A. Pevsner, H.J. Schreiber, A. Nadtochy, Cheng Chen, R. Fabbretti, M. Merk, P. Vikas, L. Baksay, E. Shumilov, M. Sachwitz, David Stickland, Dimitri Bourilkov, Bolek Wyslouch, W. Kittel, K. Strauch, V. Shoutko, J. Behrens, J. M. Le Goff, G. S. Sanders, J. A. Rubio, R. Rosmalen, J. D. Burger, G. Rahal-Callot, A. Malinin, A. C. Weber, P. J. Li, Raffaello D'Alessandro, X.R. Shi, Chenjie Gu, P. Spillantini, L. Luminari, M. S. Sarakinos, G. Landi, N. E. Moulai, E. Fiandrini, C. Zaccardelli, C. Grinnell, D. Perret-Gallix, M.L. Chen, M. Tonutti, K. Sudhakar, K. Schultze, T. Foreman, H. Suter, C.F. He, S. Beingessner, Leonardo Merola, Simone Paoletti, K. N. Qureshi, E. Koffeman, H.R. Dimitrov, M. Hebert, Barry Blumenfeld, D. Lanske, A. A. Syed, L. Antonov, P. McBride, M. Fabre, Manjit Kaur, T. Azemoon, J.H. Wang, Mingshui Chen, B. Bouwens, H. R. Gustafson, D. DiBitonto, A. Gougas, U. Uwer, A. Chen, P. K. Malhotra, H. A. Rizvi, G. Schwering, C. Dionisi, J. Salicio, A. Kunin, X. L. Wang, H. Akbari, K. Lübelsmeyer, M. Pauluzzi, W.W. Kinnison, H. Hoorani, T. Paul, Marcos Cerrada, W. G. Ma, F. Marion, J. M. Salicio, Z.M. Wang, D. Kirkby, G. Sauvage, F. Crijns, W. J. Metzger, S. Schulte, M. L. Brooks, Gerard Fernandez, M. Gailloud, K. Schmiemann, Y. J. Pei, Q.Y. Yang, P. Marchesini, Harvey B Newman, K. Hilgers, Jun Guo, E. Nagy, F. DeNotaristefani, Kajari Mazumdar, T.R. McMahon, A. Kasser, X. J. Yan, S. Müller, Jozsef Toth, Ming Zeng, D. Ren, P. Arce, J. Mnich, Ingrid U. Scott, J. Lettry, P. Berges, D. Pandoulas, E. Brambilla, M. Diemoz, A. Hasan, J. Shukla, M. Röhner, A. Rubbia, S. Lanzano, J.P. Burq, Valery Schegelsky, Antonino Zichichi, Ph Fisher, H. Rykaczewski, Elisabetta Gallo, Xd Cai, E. Valente, Y.F. Mao, J. Bao, Y. D. Xu, U. Vikas, Y. Mir, C. H. Ye, Sc Yeh, G. Organtini, U. Herten, L. Romero, S. J. Fan, J. Perrier, Qun Wang, M. Bourquin, U. K. Chaturvedi, R. Malik, Georgi Sultanov, Fl Linde, T. S. Dai, Wt Lin, R. C. Ball, D.N. Mao, A. Nippe, S. Chung, Vincenzo Innocente, Pierre Lecomte, P.V.K.S. Baba, M. Bocciolini, Attilio Santocchia, Jean Fay, M. Dhina, F. Ferroni, G. Sartorelli, M. Gruenewald, Y. Zeng, Igor Vorobiev, L. Barone, R. A. Khan, S. Reucroft, Jérôme Rose, P. Bagnaia, G. Finocchiaro, Adrian Biland, C. Y. Chien, S. Riemann, V. K. Gupta, J. Busenitz, Pierluigi Paolucci, J. M. Lubbers, S. Shotkin, G. Gratta, V. P. Andreev, F. C. Erné, F. Plasil, R. T. Van de Walle, T. E. Coan, H.F. Chen, F. Marzano, T. Spickermann, Y. S. Lu, P. Razis, W. J. Burger, M. Chemarin, D. Goujon, Bernard Ille, A. Tsaregorodtsev, Davide Piccolo, Simonetta Gentile, G. M. Chen, J. Berdugo, W. Friebel, Jiunn-Wei Chen, Z.Q. Yang, D.W. Schmitz, J. Field, M. MacDermott, J. D. Swain, Zhuoxiang Ren, M. Wadhwa, D. Duchesneau, Robert Clare, S. Rosier-Lees, J.J. Blaising, D. J. Schotanus, Thomas Hebbeker, Paul Lecoq, R. W. Kraemer, B. Lindermann, H. Anderhub, M. A. Niaz, A. Engler, A. Böhm, L. Urbán, M. Napolitano, J. M. You, E. Longo, J.P. Martin, M. Capell, V. R. Krastev, H. S. Chen, L. Servoli, Y. H. Chang, T. Angelov, I. C. Brock, E. Dénes, H. S. Fesefeldt, George Alverson, M. Rescigno, G. Coignet, J. S. Kapustinsky, G. A. Yang, O. Rind, I. Sheer, G. B. Mills, D. Wright, C. J.W.P. Timmermans, Jianming Qian, E. Sajan, G. Hu, M. Möller, L.Z. Sun, M. Vivargent, I. Leedom, Maurizio Biasini, H. Hofer, V. Plyaskin, P. Schmitz, H. Vogel, P. Denes, Marta Felcini, T. Kramer, Marco Meschini, K. Freudenreich, Carlos Willmott, O. Fackler, K. L. Tung, Felicitas Pauss, R. Morand, M. T. Dova, Francesco Becattini, Y. F. Wang, H. O. Cohn, C. Li, Richard Mount, G.G.G. Massaro, C. Maña, P. Le Coultre, H. T. Li, D. Antreasyan, H. El Mamouni, D. McNally, P. Zemp, R. de Asmundis, Georgios Tsipolitis, K. Hangarter, Qi An, X. T. Cui, R. Barillère, Christopher George Tully, H. Janssen, K.S. Yang, I. Vetlitsky, R. Sehgal, E. Gonzalez, R.J. Wu, S. Jezequel, C. R. Wang, P. Kapinos, G. Chiefari, S. Shevchenko, G. Herten, Wolfgang Lohmann, R. Starosta, Torre Wenaus, Bernardo Adeva, B. Bertucci, A. Klimentov, D. Luckey, Gy L. Bencze, J.A. Bakken, Kenneth Francis Read, Reinhard W. Schulte, G. Viertel, Y Y. Xie, Nicanor Colino, F. Behner, S. P. Ahlen, Samuel C.C. Ting, D. Z. Shen, M. Sassowsky, G.H. Wang, H. Schopper, Christine Buisson, S. S. Gau, S. Gele, H. L. Zhuang, E. Drago, G. Forconi, Pablo Garcia-Abia, Alain Hervé, J.C. Sens, P. A. Piroué, A. Bay, B. Stringfellow, Z.Z. Xu, Carlo Civinini, M. Maolinbay, P.G. Seiler, G. Raven, Y. Karyptakis, A. Khokhar, X.G. Li, M. Aguilar-Benitez, R. Bizzarri, Steven Goldfarb, M. White, E. Soderstrom, M. Yzerman, J. Schwenke, G. Passaleva, S. Röhner, F. Wittgenstein, P. Extermann, L. Ludovici, M. Chmeissani, Z.Y. Lin, A. Marin, T. Driever, A. Degré, Y. Mi, L. Martinez-Laso, S. C. Tonwar, A. Atamanchuk, Frank Filthaut, M. M. Ilyas, C. Luci, N. Produit, Thomas Ferguson, A. Sopczak, J. Schütte, R. Weill, D. Hauschildt, A. Arefiev, R. Y. Zhu, Z.F. Gong, M. Caria, G. Carlino, S. Morganti, A. Koulbardis, M. Schneegans, B.N. Jin, A. L. Anderson, V. Koutsenko, W. Krenz, Ying Wu, J. F. Zhou, D.H. Zhang, S. X. Wu, Ph. Rosselet, M. Steuer, Atul Gurtu, K. Deiters, J. Weber, B. P. Roe, A. Bujak, Oliver Kornadt, M. Pohl, Guofan Hu, R.L. Sumner, J. G. Branson, Tariq Aziz, H. Stone, Crisostomo Sciacca, Marco Pieri, M. N. Kienzle-Focacci, C. Neyer, D. M. Lee, H. Nowak, Roberto Battiston, D. Boutigny, Gerjan Bobbink, J. Ulbricht, B. Borgia, W. Wallraff, I. Clare, P. Göttlicher, J. B. Ye, F. Cesaroni, R. Leiste, B. Monteleoni, F. Sticozzi, C. Spartiotis, S. Banerjee, Z. L. Xue, Zp Zhang, Alberto Aloisio, A. Ricker, Ph. Lebrun, Z. W. Yin, S. N. Ganguli, Th. Meinholz, J. Wenninger, X. W. Tang, B. Zhou, B. C.C. van der Zwaan, U. Becker, H. Vogt, F. J. Eppling, L. W. Jones, D. S. Yan, S. M. Ting, W. Y. Chen, N. Yunus, P. Duinker, D. Linnhofer, Federico Carminati, G. M. Bilei, Andrea Contin, S. Patricelli, Q. Ye, Luca Lista, D. Fernandez, Yanwen Liu, X. Leytens, A. Krivshich, B. L. Betev, and G. Mirabelli
Subjects: Physics, rnuons, Nuclear and High Energy Physics, Muon, Condensed matter physics, dilepton events, 010308 nuclear & particles physics, Electron–positron annihilation, Física, Electron, 01 natural sciences, lcsh:QC1-999, Nuclear physics, 0103 physical sciences, 010306 general physics, Mixing (physics), Ciencias Exactas, L3 data, lcsh:Physics
Abstract: A more precise determination of the B°-B ° mixing parameter in Z ° decays based on a fourfold increase in statistics has been made using the 1990 and t99t L3 data. The analysis of the dilepton events, rnuons and electrons, gives: Za = 0.121 + 0.017 (stat) :t: 0.006 (sys). Using the value Of Xd measured at the "f(4S) we derive the following limit for Zs: Zs > 0.16 (90% CL)., Facultad de Ciencias Exactas
Published: 1992

43. Contributor contact details

Author: Paul Paquin, Marie Jane Fallourd, Luisa Viscione, S.E. Kemp, M.G. Lindley, M. Saarela, Peter Berry Ottaway, J. Gruenwald, G. Rysstad, K. Johnstone, D.I. Givens, K.E. Kliem, Phil Kelly, Brad W. Woonton, Geoffrey W. Smithers, M. Mellema, A. Bot, P. Jelen, R. Jiménez-Flores, I. Higuera-Ciapara, Y. Pouliot, P. Ashurst, P.V. Paulsen, R.J. Maughan, A. Farah, C.I. Heck, E. Gonzalez de Mejia, D. Sorenson, J. Bogue, B.M. Popkin, G.M. Bray, B. Caballero, B. Frei, and W.C. Willett
Published: 2009

44. Immunoreactivity reduction of soybean meal by fermentation, effect on amino acid composition and antigenicity of commercial soy products

Author: Juana Frias, C. Vidal-Valdeverde, E. Gonzalez de Mejia, Y.S. Song, and Cristina Martínez-Villaluenga
Subjects: Antigenicity, Food industry, Glycine max, Soybean meal, Hypoallergenic foods, Microbial proteolysis, Saccharomyces, Analytical Chemistry, Food allergy, medicine, Food science, Protien, chemistry.chemical_classification, biology, business.industry, food and beverages, General Medicine, biology.organism_classification, medicine.disease, Amino acid, chemistry, Fermentation, business, Soybean, IgE immunoreactivity, Lactobacillus plantarum, Food Science
Abstract: Food allergy has become a public health problem that continues to challenge both the consumer and the food industry. The objectives of this study were to evaluate the reduction of immunoreactivity by natural and induced fermentation of soybean meal (SBM) with Lactobacillus plantarum, Bifidobacterium lactis, Saccharomyces cereviseae, and to assess the effect on amino acid concentration. Immunoreactivity of commercially available fermented soybean products and ingredients was also evaluated. ELISA and western blot were used to measure IgE immunoreactivity using plasma from soy sensitive individuals. Commercial soy products included tempeh, miso and yogurt. Fermented SBM showed reduced immunoreactivity to human plasma, particularly if proteins were, This work was partly supported by the Comision Española Interministerial de Ciencia y Tecnología (CICYT) with project number AGL2004-0886/ALI and USDA-Future Foods Initiative
Published: 2008

45. Assessment of Bone and Joint DiseasesRenal Osteodystrophy

Author: E GONZALEZ, Z ALALY, and K MARTIN
Published: 2006

46. High body condition score combined with a reduced lambing to ram introduction interval improves the short-term ovarian response of milking Lacaune ewes to the male effect

Author: N. Debus, E. Laclef, A. Lurette, M. Alhamada, A. Tesniere, E. González-García, J-B. Menassol, and F. Bocquier
Subjects: Commercial farm, Dairy ewes, Male effect, Organic farming, Progesterone, Animal culture, SF1-1100
Abstract: The male effect is an effective natural technique to induce off-season ovulation and ultimately mating or artificial insemination in small ruminants. It constitutes an alternative to hormonal treatments in conventional breeding systems and, to shift and organise the yearly production cycle, is currently the only solution complying with European organic standards. However, its associated performances are still heterogeneous, both in terms of the global response and the extent of reproductive synchronisation of the females, due to complex interactions with environmental factors that limit its use on commercial farms. This study was carried out on a French organic farm under commercial conditions to investigate, in the field and across five consecutive years, the main parameters affecting the early ovarian response to a ram effect on Lacaune dairy ewes. While the within-year binary logistic regressions yielded contrasting results, the cross-year mixed-effect binary logistic regression models clearly showed that parameters associated with the nutritional state of the animals have a profound influence on the ovarian response of the ewes. Indeed, the probabilities of a spontaneous resumption of ovarian activity before the ram effect and of an early ovarian response to the ram effect were positively associated with the body condition score, total milk production and the age of the animals, while being negatively associated with the milk production level at the 3rd milk recording. The probabilities of a spontaneous resumption of ovarian activity before the ram effect were positively associated with the interval between lambing and the introduction of the rams. Altogether, these results indicate that the ovarian performances in response to a male effect follow a bell-curve pattern with optimal performances depending upon a complex combination between photoperiodic and nutritional cues. Regarding these latter, this study highlights the major contribution of body reserves and energy balance dynamics.
Published: 2022
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47. Time series prediction with neural networks. Application to electric energy demand

Author: M JARAMILLO, D CARMONA, E GONZALEZ, and J ALVAREZ
Published: 2005

48. Diarrea asociada a Clostridioides difficile en pacientes de servicios quirúrgicos en México

Author: R. Morfín-Otero, S. Petersen-Morfín, S.A. Aguirre-Díaz, H.R. Pérez-Gómez, E. Garza-González, E. González-Díaz, S. Esparza-Ahumada, J.A. Velarde-Ruiz Velasco, G. León-Garnica, R. Escobedo-Sánchez, and E. Rodríguez-Noriega
Subjects: Diarrhea, Clostridioides difficile, Healthcare-associated infections, Infections in surgery, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Resumen: Introducción: Clostridioides difficile (CD) es la primera causa de diarrea asociada al cuidado de salud en los países desarrollados. En los últimos años, la incidencia de la infección asociada a CD (ICD) ha aumentado en el ámbito mundial. En México, la información al respecto es escasa y se conoce poco sobre los factores de riesgo para esta enfermedad en pacientes hospitalizados en servicios quirúrgicos Material y métodos: Estudio de casos y controles. Se compararon hallazgos epidemiológicos y factores de riesgo entre pacientes quirúrgicos con ICD confirmada por PCR contra pacientes quirúrgicos con diarrea PCR negativa y contra pacientes quirúrgicos sin diarrea. Se realizó análisis estadístico mediante el paquete estadístico SPSS versión 22.0. Resultados: La mayoría de los pacientes quirúrgicos con ICD correspondían a las áreas de neurocirugía, cardiocirugía, ortopedia y cirugía general. El 53% de los casos de ICD se asociaron a la cepa hipervirulenta de CD NAP1/027. La presencia de moco en heces (RM 1.5, p = 0.001), fiebre (RM 1.4, p = 0.011), leucocitos en heces (RM 3.2, p =
Published: 2020
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49. Clostridioides difficile-associated diarrhea in surgical service patients in Mexico

Author: R. Morfín-Otero, S. Petersen-Morfín, S.A. Aguirre-Díaz, H.R. Pérez-Gómez, E. Garza-González, E. González-Díaz, S. Esparza-Ahumada, J.A. Velarde-Ruiz Velasco, G. León-Garnica, R. Escobedo-Sánchez, and E. Rodríguez-Noriega
Subjects: Diarrea, Clostridium difficile, infecciones asociadas al cuidado de salud, Infecciones en cirugía, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract: Introduction: Clostridium difficile is the first cause of healthcare-associated diarrhea in developed countries. In recent years the incidence of C. difficile infection (CDI) has increased worldwide. There is not much information on the topic in Mexico, and little is known about the risk factors for the infection in patients that are hospitalized in surgical services. Materials and methods: A case-control study was conducted that compared the epidemiologic findings and risk factors between surgical patients with PCR-confirmed CDI, surgical patients with diarrhea and a negative PCR test, and surgical patients with no diarrhea. The statistical analysis was carried out using the SPSS version 22.0 program. Results: The majority of the surgical patients with CDI belonged to the areas of neurosurgery, cardiac surgery, orthopedics, and general surgery. A total of 53% of the CDI cases were associated with the hypervirulent CD NAP1/027 strain. The presence of mucus in stools (OR: 1.5, p = 0.001), fever (OR: 1.4, p = 0.011), leukocytes in stools (OR: 3.2, p
Published: 2020
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50. Atención integral del neonato con encefalopatía hipóxico-isquémica en España

Author: Juan Arnaez, Nuria Herranz-Rubia, Alfredo Garcia-Alix, J. Diez-Delgado, I. Benavente-Fernández, I. Tofé, A.E. Jerez, J.A. Hurtado, J.M. Ceballos, M.L. Millán, M.D. Esquivel, C. Ruiz, M. Baca, E. Tapia, M. Losada, E. Torres, A. Pavón, P.J. Jiménez, F. Jiménez, M.P. Ventura, S. Rite, T. González, R.P. Arias, P.R. Balliu, J.M. Lloreda-García, J.L. Alcaráz, C. Tapia, A. de la Morena, I. Centelles, I. Güemes, J. Estañ, A. Alberola, S. Aparici, R. López, J. Beceiro, B. García, L. Martínez, E. González, L. Arruza, M.D. Blanco, M.T. Moral, B. Arias, F. Mar, J. Jiménez, G. Romera, A. Cuñarro, C. Muñóz, F. Cabañas, E. Valverde, R. Montero, J.C. Tejedor, C. Santana, B. Reyes, S. Romero, A. Orizaola, M. Baquero, D. Hernández, A. Pantoja, C. Vega-del-Val, L. Castañón, E.P. Gutiérrez, M. Benito, S. Caserío, G. Arca, M.J. García, M.A. López-Vílchez, L. Castells, M. Domingo, W. Coroleu, H. Boix, R. Porta, A. García-Alix, S. Martínez-Nadal, E. Jiménez, E. Sole, M. Albújar, E.M. Fernández, A.R. Barrio, E. Piñán, A. Avila-Alvarez, M.E. Vázquez, N. Balado, P.A. Crespo, M.L. Couce, A. Concheiro-Guisán, I. Esteban, A. Lavilla, V. Alzina, A. Aguirre, B. Loureiro, I. Echániz, M.D. Elorza, and A. Euba
Subjects: Hypoxia-ischaemia, Asphyxia, Newborn, Therapeutic hypothermia, Biomarkers, Prognosis, Pediatrics, RJ1-570
Abstract: Resumen: Introducción: Apenas conocemos cómo es la asistencia de los recién nacidos (RN) con encefalopatía hipóxico-isquémica (EHI) en hipotermia terapéutica (HT), especialmente si existen protocolos asistenciales, la neuromonitorización que se realiza o cómo es la aproximación al pronóstico neurológico. Este conocimiento permite detectar e implementar áreas de mejora asistencial. Método: Estudio transversal de los 57 hospitales españoles que realizaban HT en 2015, mediante cuestionario sobre: 1) la disponibilidad de protocolos y de recursos tecnológicos; 2) el uso de herramientas de neuromonitorización; 3) los conocimientos de los profesionales; 4) la información pronóstica que se da los padres, y 5) el informe al alta y del plan de seguimiento. Resultados: El 95% utiliza enfriamiento corporal-total servocontrolado y dispone de protocolos específicos de actuación. El 70% utiliza sedación y el 68% deja al paciente a dieta absoluta. La monitorización con electroencefalografía integrada por amplitud se utiliza en más del 80% de los centros, aunque solo en el 50% la enfermera es capaz de interpretarlo. La saturación de oxígeno cerebral es escasamente monitorizada (16%). Entre los estudios diagnóstico-pronósticos, la neuroimagen es universal, pero los neurobiomarcadores apenas se utilizan (29%). Solo el 21% ofrece información pronóstica antes de las 72 h de vida; sin presencia de la enfermera en el 70%. El seguimiento lo realiza el neuropediatra (84%), con una duración desigual entre centros. Conclusiones: La asistencia del RN con EHI en España es adecuada, con áreas de mejora en: neuromonitorización, sedación, marco temporal de la información pronóstica, trabajo en equipo y estandarización de la duración del seguimiento. Abstract: Introduction: There is not much information about the care of infants with hypoxic-ischaemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) in Spain. This includes whether protocols are routinely used, the type of neuro-monitoring performed, and how information on the neurological prognosis is presented to families. The answers to these would allow to detect and implement areas of improvement. Method: A cross-sectional analysis was performed on the responses to structured questionnaires sent to all the Spanish neonatal units that were performing TH in June 2015. Questions were divided into 5 sections: 1) the availability of protocols and technological resources, 2) the use of neuro-monitoring tools, 3) the knowledge and training of the professionals; 4) the prognostic information given to the parents; and 5) the discharge report and the follow-up plan. Results: Most centres (95%) use servo controlled whole-body cooling methods and have specific management protocols. Sedation is used in 70% of centres, and in 68% of them the onset of enteral feeding is delayed until the end of the cooling period. Amplitude-integrated electroencephalography monitoring is used in more than 80% of the centres, although only in 50% are nurses able to interpret it. Cerebral oxygen saturation is not often monitored (16%). As regards diagnostic-prognostic studies, neuroimaging is universal, but brain damage biomarkers are hardly used (29%). Prognostic information is offered within the first 72 posnatal hours in 21% of the centres, and is given without the presence of the nurse in 70% of the centres. Follow-up is performed by a neuro-paediatrician (84%), with an uneven duration between centres. Conclusions: The care of infants with HIE treated with TH in Spain is generally adequate, although there are areas for improvement in neuromonitoring, sedation, prognostic information, teamwork, and duration of follow-up.
Published: 2020
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