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Two octa-coordinated lanthanum (III) complexes of deprotonated azaphosphor β-diketon and diimine ligands, [LnL 3 Q] (L = [Cl 2 CHC(O)NP(O)(NC 6 H 12 ) 2 ], Q = Phen (C1) and Bipy (C2)), were synthesized and characterized by elemental analysis, IR, and NMR spectra. X-ray crystallography revealed a distorted tetragonal antiprism LaO6N2 coordination geometry around the lanthanum atom in both compounds. Nano-sized complexes (Ć1 and Ć2) were synthesized via a sonochemical process and analyzed using SEM and XRPD. TGA-DTA analysis were performed on complexes in both bulk and nano scales. Redox behavior was also examined by cyclic voltammetry. The interaction between the complexes and calf thymus DNA (ct-DNA) was investigated using UV-Vis spectroscopy, fluorescence titration, viscosity measurements, and gel electrophoresis. C2 and Ć2 likely intercalate between DNA base pairs through van der Waals forces and hydrogen bonding, whereas C1 and Ć1 interact with DNA via groove binding. Further, result indicated the apparent association constant (K app ) in the range of 4.53 × 10 4  M -1 -26.86 × 10 4  M -1 with the highest value for nanocomplex Ć2. Fluorescence studies revealed dynamic and static quenching for C1, while the other compounds followed a static quenching process. Hirshfeld surface analysis and the NCI method were employed to demonstrate how non-covalent interactions influence the crystal packing through intermolecular interactions., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Lung cancer has been one of the leading causes of death over the past century. Unfortunately, the reliance on conventional methods to diagnose the phenotypic properties of tumors hinders early-stage cancer diagnosis. However, recent advancements in identifying disease-specific nucleotide biomarkers, particularly microRNAs, have brought us closer to early-stage detection. The roles of miR-155, miR-197, and miR-182 have been established in stage I lung cancer. Recent progress in synthesizing nanomaterials with higher conductivity has enhanced the diagnostic sensitivity of electrochemical biosensors, which can detect low concentrations of targeted biomarkers. Therefore, this review article focuses on exploring electrochemical biosensors based on microRNA in lung cancer., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Pancreatic cancer (PC) is one of the deadliest cancers worldwide. MicroRNAs (miRs) are sensitive molecular diagnostic tools that can serve as highly accurate biomarkers in many disease states in general and cancer specifically. MiR-based electrochemical biosensors can be easily and inexpensively manufactured, making them suitable for clinical use and mass production for point-of-care use. This paper reviews nanomaterial-enhanced miR-based electrochemical biosensors in pancreatic cancer detection, analyzing both labeled and label-free approaches, as well as enzyme-based and enzyme-free methods., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Gastrointestinal (GI) cancers are one of the most common causes of cancer-related mortality. The discovery of microRNAs (miRs) and their unique role in cancer and other diseases has prompted the development of highly sensitive molecular diagnostic tools using nanomaterials as sensitive and specific biosensors. Among these, electrochemical biosensors, which are based on a simple and inexpensive design, make them desirable in clinical applications as well as a mass-produced point-of-care device. We review miR-based electrochemical biosensors in GI cancer and examine the use of nanoparticles in the evolving development of miR-based biosensors. Among these, a number of approaches including redox labeled probes, catalysts, redox intercalating agents and free redox indicators are highlighted for use in electrochemical biosensor technology., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)