1. SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility.
- Author
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Bahadur G, Acharya S, Muneer A, Huirne J, Łukaszuk M, Doreski PA, and Homburg R
- Subjects
- Angiotensin-Converting Enzyme 2, COVID-19, COVID-19 Testing, Coronavirus Infections diagnosis, Humans, Male, Pandemics, Peptidyl-Dipeptidase A metabolism, Pneumonia, Viral diagnosis, RNA, Viral analysis, Receptors, Cell Surface analysis, Receptors, Cell Surface metabolism, SARS-CoV-2, Semen virology, Serine Endopeptidases analysis, Serine Endopeptidases metabolism, Spermatozoa virology, Spike Glycoprotein, Coronavirus metabolism, Tissue Donors, Betacoronavirus, Clinical Laboratory Techniques, Coronavirus Infections transmission, Infertility, Male therapy, Pneumonia, Viral transmission, Testis virology
- Abstract
The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted., (Copyright © 2020 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
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