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2 results on '"Dongchoon Ahn"'

1. Red cell interactions with amyloid-β1–40 fibrils in a murine model

Author

Luke B. Ravi, Suresh Poosala, Dongchoon Ahn, Francis J. Chrest, Edward L. Spangler, Rajadas Jayakumar, Enika Nagababu, Joy G. Mohanty, Mark Talan, Donald K. Ingram, and Joseph M. Rifkind

Subjects
Erythrocytes, β-Amyloid, Alzheimer's disease, Murine in vivo study, Spleen, Liver, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Vascular amyloidosis in Alzheimer's disease (AD) results in the exposure of red blood cells to β-amyloid fibrils (Aβ). The potential in vivo ramifications of this exposure have been investigated by injecting Aβ1–40 alone or Aβ-bound mouse red blood cells into the circulation of C57BL/6 mice. Results indicate that when Aβ1–40 is injected alone, a transient uptake of the fibrils by red blood cells occurs in vivo. When Aβ-bound red blood cells were injected, β-amyloid is rapidly removed from these cells in vivo. Double-labeling experiments indicate that while some of the red blood cells bound to Aβ1–40 are removed from circulation, a major fraction of these cells remain in circulation even after Aβ is removed. Immunohistochemistry of murine tissue samples obtained after sacrificing the animals suggests that within 1 h after injection of Aβ1–40 or Aβ-bound red blood cells, Aβ is found in spleen phagocytes and liver Kupffer cells. Heme staining further indicates that the binding of Aβ1–40 to red blood cells enhances red cell phagocytosis by the spleen.

Published
2005
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2. Red cell interactions with amyloid-β1–40 fibrils in a murine model

Author

Suresh Poosala, Francis J. Chrest, Luke B. Ravi, Edward L. Spangler, Enika Nagababu, Mark I. Talan, Joseph M. Rifkind, Joy G. Mohanty, Rajadas Jayakumar, Donald K. Ingram, and Dongchoon Ahn

Subjects
Male, Pathology, medicine.medical_specialty, Erythrocytes, Amyloid, Phagocytosis, Spleen, Biology, lcsh:RC321-571, Mice, chemistry.chemical_compound, In vivo, Murine in vivo study, medicine, Animals, Heme, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Amyloid beta-Peptides, Red Cell, Amyloidosis, Alzheimer's disease, medicine.disease, Molecular biology, Peptide Fragments, Staining, Mice, Inbred C57BL, medicine.anatomical_structure, Neurology, chemistry, Liver, Models, Animal, β-Amyloid, Protein Binding
Abstract

Vascular amyloidosis in Alzheimer's disease (AD) results in the exposure of red blood cells to beta-amyloid fibrils (A beta). The potential in vivo ramifications of this exposure have been investigated by injecting A beta(1-40) alone or A beta-bound mouse red blood cells into the circulation of C57BL/6 mice. Results indicate that when A beta(1-40) is injected alone, a transient uptake of the fibrils by red blood cells occurs in vivo. When A beta-bound red blood cells were injected, beta-amyloid is rapidly removed from these cells in vivo. Double-labeling experiments indicate that while some of the red blood cells bound to A beta(1-40) are removed from circulation, a major fraction of these cells remain in circulation even after A beta is removed. Immunohistochemistry of murine tissue samples obtained after sacrificing the animals suggests that within 1 h after injection of A beta(1-40) or A beta-bound red blood cells, A beta is found in spleen phagocytes and liver Kupffer cells. Heme staining further indicates that the binding of A beta(1-40) to red blood cells enhances red cell phagocytosis by the spleen.

Published
2005

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