Search

Your search keyword '"Donald R, Gerecke"' showing total 6 results
Start Over Author "Donald R, Gerecke" Publisher elsevier
6 results on '"Donald R, Gerecke"'

1. List of contributors

Author

Arturo Anadón, Rudolf Andrys, Pavel Avdonin, Jiri Bajgar, Mahdi Balali-Mood, Frank Balszuweit, Atrayee Banerjee, Cheryl B. Bast, Daria Belinskaia, Vijay K. Bharti, Claire E. Bollinger, Robert P. Casillas, Ryan Clark, Edward D. Clarkson, Toby B. Cole, Rhian B. Cope, Robert W. Coppock, Lucio G. Costa, Wolf-D. Dettbarn, Alzbeta Dlabkova, Robin B. Doss, Margitta M. Dziwenka, Jorge Estevez, Tim J. Evans, John K. Fink, Swaran J.S. Flora, Clement E. Furlong, Josef Fusek, Jacqueline Garrick, Jeffery M. Gearhart, Donald R. Gerecke, Dana F. Glass-Mattie, Saryu Goel, Nikolay Goncharov, Richard K. Gordon, Joshua P. Gray, Zoran Grubic, Kavita Gulati, Ramesh C. Gupta, Sharon M. Gwaltney-Brant, Tracey A. Hamilton, Kenneth J. Harris, Darryl B. Hood, Edward M. Jakubowski, Richard Jenkins, David A. Jett, Yuqin Jiao, Harald John, Nathan H. Johnson, Milan Jokanović, Daniel Jun, Georgy Karakashev, Jiri Kassa, Maja Katalinic, Kai Kehe, Natalia Khlebnikova, Urmila P. Kodavanti, Ekaterina Korf, Nadezhda Koryagina, Bojan Kovač, Gopala Krishna, Mayur Krishna, Kamil Kuca, Dinesh Kumar, Yukio Kuroiwa, Sergey Kuznetsov, Kamil Kuča, Joseph C. Larsen, Mikhail Leninskiy, Jing Liu, Heather Lochotzki, Oksana Lockridge, Jordana Lockwich, Bommanna G. Loganathan, Dragana Lončar-Stojiljković, Sofya V. Lushchekina, Megan E. Lyman, Mark Maguire, Galina F. Makhaeva, Jitendra K. Malik, David Malinak, Tomaz Mars, Judit Marsillach, María-Rosa Martínez-Larrañaga, Patrick Masson, Shigeki Masunaga, Monique McCallister, Linda A. McCauley, Roger O. McClellan, Patrick M. McNutt, Edward C. Meek, Elaine Merrill, Sylvia Milanez, Igor Mindukshev, Katarina Mis, Jan Misik, Michael J. Murphy, Kamil Musilek, Tamie Nakajima, Marian R. Nelson, Eugenie Nepovimova, Tetsu Okumura, Jiri Patocka, Katarina Pegan, Jaroslav Pejchal, Sergej Pirkmajer, René Pita, Jason Pitt, Yiuka Pitt, Gennady E. Platoff, Carey N. Pope, Andrey Radilov, Anu Rahal, Aramandla Ramesh, Arunabha Ray, Vladimir Rembovskiy, Raina Rhoades, Rudy J. Richardson, Dragana Ristić, Peter J. Robinson, Alejandro Romero, Chris Ruark, Harry Salem, Natalia Samchenko, Tetsuo Satoh, Russell E. Savage, Elena Savelieva, Lawrence M. Schopfer, Alfred M. Sciuto, Yasuo Seto, Michael P. Shakarjian, Vladimir Shmurak, Adam Skarka, Ranko Škrbić, Miguel Sogorb, Shardell M. Spriggs, Sakshi Srivastava, Dirk Steinritz, Miloš P. Stojiljković, Neera Tewari-Singh, Horst Thiermann, Suresh Kumar Thokchom, Larry J. Thompson, Anton Ukolov, Luis G. Valerio, M.J. van der Schans, Daya R. Varma, Eugenio Vilanova, Annetta Watson, Sanjeeva J. Wijeyesakere, Tina Wismer, R. Mark Worden, Franz Worek, Linzzi K. Wright, Hidenori Yamasue, Takemi Yoshida, Toshiharu Yoshioka, Robert A. Young, Snjezana Zaja-Milatovic, Valeriy Zinchenko, and Csaba K. Zoltani

Published
2020

2. Dermal Toxicity of Sulfur Mustard

Author

Michael P. Shakarjian, Donald R. Gerecke, Robert P. Casillas, and Joshua P. Gray

Subjects
medicine.medical_specialty, Necrosis, integumentary system, Epidermis (botany), Chemistry, Inflammation, Sulfur mustard, Glutathione, Thiodiglycol, Pharmacology, Combinatorial chemistry, Nitrogen mustard, Surgery, Lipid peroxidation, chemistry.chemical_compound, medicine.anatomical_structure, Mechanism of action, Dermis, In vivo, Apoptosis, Drug delivery, medicine, Pharmaceutics, medicine.symptom, Bifunctional
Abstract

Publisher Summary This chapter deals with the cutaneous actions of sulfur mustard (SM) and discusses the basic mechanism of action and mediators involved. While stable in lipophilic solvents, SM has a half life of only 24 min at room temperature in aqueous physiological solutions, since it rapidly reacts with water to form thiodiglycol and HCl. This rapid activation of SM in an aqueous environment also allows it to react with small molecules of biological interest, as well as proteins, carbohydrates, lipids, RNA, and DNA. The initial reaction involves the formation of a cyclic ethylene sulfonium ion, which readily targets reactive groups on skin components, including sulfhydryls, phosphates, ring nitrogens, and carboxyl groups. As a bifunctional alkylating agent, SM forms monofunctional adducts and intra- and intermolecular crosslinks. Since it is so reactive and indiscriminate in its molecular targets, SM affects many pathways and is cytotoxic on many levels. There are three independent mechanisms of cytotoxicity alkylation of DNA/POLY(ADP-RIBOSE) or polymerase (PARP) activation, reactions with glutathione/lipid peroxidation, and reactions with glutathione/calcium homeostasis. Countermeasure research to date has focused primarily on the development of therapeutics, but little attention has been given to the use of advances in drug delivery, or pharmaceutics. Drug delivery by encapsulation of active moieties in nanoparticles has been increasingly used for chemotherapeutic agents such as doxorubicin. However, with the exception of barrier creams, nanoparticle-mediated cutaneous SM detoxification has largely been limited to decontamination

Published
2015

3. List of Contributors

Author

Arturo Anadón, Jaime Anderson, Jun-ichi Anzai, Michael Aschner, Pavel Avdonin, Jiri Bajgar, Kulbir Bakshi, Mahdi Balali-Mood, Frank Balszuweit, Atrayee Banerjee, Cheryl B. Bast, Rahul Bhattacharya, Claire E. Bollinger, Robert P. Casillas, Sylvain Chemtob, Ryan Clark, Edward D. Clarkson, Toby B. Cole, Robert W. Coppock, Lucio G. Costa, Wolf-D. Dettbarn, Dorothy L. Dobbins, Russell Dorsey, Margitta Dziwenka, George Emmett, Jorge Estévez, Timothy J. Evans, John K. Fink, Swaran J.S. Flora, Frode Fonnum, Clement E. Furlong, Josef Fusek, Jeffery M. Gearhart, Donald R. Gerecke, Dana F. Glass-Mattie, Saryu Goel, Nikolay Goncharov, Richard K. Gordon, Joshua P. Gray, Zoran Grubic, Kavita Gulati, Ramesh C. Gupta, Sharon M. Gwaltney-Brant, Tracey L. Hamilton, Veronique Hauschild, Nichole D. Hein, Corey J. Hilmas, Elora Hilmas, Darryl B. Hood, Edward M. Jakubowski, Richard O. Jenkins, David A. Jett, George C-T Jiang, Yuqin Jiao, Harald John, Nathan H. Johnson, Milan Jokanović, Daniel Jun, Beena M. Kadakkuzha, Jiri Kassa, Maja Katalinic, Kai Kehe, Natalia Khlebnikova, Joseph King, Urmila P. Kodavanti, Jan Korabecny, Gopala Krishna, Nadezhda Krivorotova, Kamil Kuca, Yukio Kuroiwa, Anatoliy Kuznetsov, Sergey Kuznetsov, Joseph C. Larsen, Yiuka Leung, Jing Liu, Xin-an Liu, Oksana Lockridge, Bommanna G. Loganathan, Andres M. Lugo, Mark Maguire, Galina F. Makhaeva, Jitendra K. Malik, Tomaz Mars, Maria Rosa Martínez-Larrañaga, Patrick Masson, Shigeki Masunaga, Monique McCallister, Linda A. McCauley, Patrick M. McNutt, Edward Meek, Elaine Merrill, Sylvia Milanez, Igor Mindukshev, Katarina Mis, Shree Mulay, Michael J. Murphy, Kamil Musilek, Trond Myhrer, Tetsu Okumura, Dennis Opresko, Tatiana Orlova, Aas Pål, Xiaoping Pan, Jiri Patocka, Sergej Pirkmajer, Rene Pita, Jason Pitt, Carey Pope, Daria Prokofieva, Andrey Radilov, Shashi K. Ramaiah, Aramandla Ramesh, Arunabha Ray, Kausik Ray, Vladimir Rembovskiy, Raina Rhoades, Rudy J. Richardson, Valerio Rizzo, Peter J. Robinson, Chris Ruark, Harry Salem, Tetsuo Satoh, Russell E. Savage, Elena Savelieva, Lawrence M. Schopfer, Alfred M. Sciuto, Yasuo Seto, Michael P. Shakarjian, Miguel Sogorb, Hermona Soreq, Sigrun Hanne Sterri, Melissa Stick, Kouichiro Suzuki, Kenji Taki, Horst Thiermann, Larry J. Thompson, Chibuzor Uchea, Anton Ukolov, Luis G. Valerio, Deon Van der Merwe, Marcel J. van der Schans, Daya R. Varma, Eugenio Vilanova, Maxim Vinokurov, Natalia Voitenko, Nir Waiskopf, Annetta Watson, Sanjeeva J. Wijeyesakere, Tina Wismer, Randall L. Woltjer, R. Mark Worden, Franz Worek, Linnzi Wright, David T. Yeung, Takemi Yoshida, Robert A. Young, Snjezana Zaja-Milatovic, Valeriy Zinchenko, and Csaba K. Zoltani

Published
2015

4. List of Contributors

Author

Arturo Anadón, Jaime Anderson, Jun-ichi Anzai, Michael Aschner, Peter Avdonin, Vladimir Babakov, Michael C. Babin, Debasis Bagchi, Manashi Bagchi, Jiri Bajgar, Kulbir Bakshi, Frank Balszuweit, Atrayee Banerjee, Cheryl Bast, Val R. Beasley, R. Bhattacharya, Whitney Burrows, Robert P. Casillas, Sylvain Chemtob, Edward D. Clarkson, R.W. Coppock, Lucio G. Costa, T.V. Damodaran, Wolf-D. Dettbarn, Sergey Dulov, Robert W. Enzenauer, Elena Ermolaeva, Timothy J. Evans, Tama Evron, Govinder Flora, S.J.S. Flora, Frode Fonnum, Clement E. Furlong, Josef Fusek, Anshoo Gautam, Jeffery M. Gearhart, Donald R. Gerecke, Brian C. Geyer, Lidia Glashkina, Dana F. Glass, Nikolay Goncharov, Marion K. Gordon, Richard K. Gordon, Joshua P. Gray, Zoran Grubic, Kavita Gulati, Ramesh C. Gupta, Wanda M. Haschek-Hock, Veronique Hauschild, Corey J. Hilmas, Elora Hilmas, Darryl B. Hood, J.F. Humbert, Edward M. Jakubowski, Richard Jenkins, David A. Jett, George C.-T. Jiang, Harald John, Nathan H. Johnson, Milan Jokanović, Dhaval N. Joshi, Daniel Jun, Kiran Kalia, Jiri Kassa, Alexandre M. Katos, Kai Kehe, R.J. Kern, Natalia Khlebnikova, Joseph King, Mark Krasna, Ilia Krasnov, Kamil Kuca, Sergey Kuznetsov, Joseph C. Larsen, Francis C. Lau, Jing Liu, Oksana Lockridge, Bommanna G. Loganathan, Andres M. Lugo, Galina F. Makhaeva, Tomaz Mars, Maria Rosa Martínez-Larrañaga, Patrick Masson, Shigeki Masunaga, Linda A. McCauley, Edward Meek, Elaine Merrill, Dejan Milatovic, Igor Mindukshev, Katarina Mis, Tsafrir S. Mor, Shree Mulay, Michael J. Murphy, Kamil Musilek, Trond Myhrer, Tetsu Okumura, Dennis Opresko, Jiri Patocka, John A. Pickrell, Sergej Pirkmajer, Ekaterina Podolskaya, Melissa J. Poole, Carey Pope, Andrey Radilov, Shashi K. Ramaiah, Aramandla Ramesh, Arunabha Ray, Vladimir Rembovskiy, Rudy J. Richardson, Peter J. Robinson, Daniel Rochu, Sci D, Chris Ruark, Igor Rybalchenko, Tetsuo Satoh, Elena Savelieva, Geetu Saxena, Lawrence M. Schopfer, Manu Sebastian, Yasuo Seto, Michael P. Shakarjian, Manoj Sharma, Alexey Shpak, Hermona Soreq, Sigrun Hanne Sterri, Kouichiro Suzuki, Kenji Taki, Sylvia S. Talmage, Horst Thiermann, Larry J. Thompson, E. Tiffany-Castiglioni, Luis G. Valerio, M.J. van der Schans, Daya R. Varma, R. Vijayaraghavan, Maxim Vinokurov, M.E. Wales, Annetta Watson, J.R. Wild, Patrick T. Williams, Tina Wismer, Randall L. Woltjer, R. Mark Worden, Franz Worek, Linnzi Wright, David T. Yeung, Robert A. Young, Shirley Zafra-Stone, Snjezana Zaja-Milatovic, Valeriy Zinchenko, and Csaba K. Zoltani

Published
2009

6. The Molecular Biology of Collagens with Short Triple-Helical Domains

Author

N. Sato, Norman D. Rosenblum, Ichiro Nishimura, Olena Jacenko, Noriko Yamaguchi, P. Castagnola, Suk P. Oh, Phyllis LuValle, G. Vasios, Y Ninomiya, R. Taylor, Mary T. McCarthy, Bjorn R. Olsen, Donald R. Gerecke, Y. Muragaki, Marion K. Gordon, and Stephen P. Sugrue

Subjects
Chemistry, Biophysics
Published
1990

Catalog

Books, media, physical & digital resources
See catalog results