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Tinnitus pathophysiology has been associated with an atypical cortical network that involves functional changes in auditory and non-auditory areas. Numerous resting-state studies have replicated a tinnitus brain network to be significantly different from healthy-controls. Yet it is still unknown whether the cortical reorganization is attributed to the tinnitus frequency specifically or if it is frequency-irrelevant. Employing magnetoencephalography (MEG), the current study aimed to identify frequency-specific activity patterns by using an individual tinnitus tone (TT) and a 500 Hz-control tone (CT) as auditory stimuli, across 54 tinnitus patients. MEG data were analyzed in a data-driven approach employing a whole-head model in source space and in sources' functional connectivity. Compared to the CT, the event related source space analysis revealed a statistically significant response to TT involving fronto-parietal regions. The CT mainly involved typical auditory activation-related regions. A comparison of the cortical responses to a healthy control group that underwent the same paradigm rejected the alternative interpretation that the frequency-specific activation differences were due to the higher frequency of the TT. Overall, the results suggest frequency-specificity of tinnitus-related cortical patterns. In line with previous studies, we demonstrated a tinnitus-frequency specific network comprising left fronto-temporal, fronto-parietal and tempo-parietal junctions., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Tinnitus assessment is a precursor for individualized treatment and outcome measurement. In the recent years, several studies proposed two-alternative forced choice (2AFC) recursive matching as a method to determine tinnitus pitch-match frequency in a standardized reliable manner. Currently, pure tones are used as comparison stimuli to assess pitch-match frequency. In this study, we investigated the psychometric quality of the method comparing different sound types. We measured 20 chronic tinnitus patients in 2 runs on 3 days. To assess pitch-match frequency, we used 2AFC recursive matching and compared results between pure tones and narrow band noise (NBN). Test-retest reliability between runs and across sound types was high (α>0.9) and increased across days. Perceived matching difficulty and time to completion decreased over repetitions. Importantly, the difference of matched frequencies (DMF) between runs was significantly less for NBN. When patients matched the spectral bandwidth of a test tone to their tinnitus, consistency was high (α=0.86) and no patient indicated continuously a pure tone. In conclusion, we recommend using NBN sounds in 2AFC recursive matching to assess pitch-match frequency as a standardized reliable method. Such a procedure could be offered as smartphone-based application to monitor tinnitus symptomatology for individualized assessment and treatment outcome., (Copyright © 2021 Elsevier B.V. All rights reserved.)

While tinnitus is known to compromise the perception of speech, it is unclear if the same holds for extralinguistic speaker information. Furthermore, research with simple tone stimuli showed that unilateral tinnitus binds spatial attention, thereby impeding the detection of auditory changes in the non-affected ear. Using dichotic listening tasks, we tested left-ear tinnitus patients and control patients for their ability to ignore speech and speaker information in the task-irrelevant ear. To this end they heard vowel-consonant-vowel (VCV) syllables simultaneously spoken by gender-ambiguous voices in one ear and male or female voices in the contralateral ear. They selectively attended to speech (Exp. 1) or speaker (Exp. 2) information in a designated target ear, by classifying either the consonant (/b/ or /g/) in VCV syllables or voice gender (male or female) while ignoring distractor voices in the other ear. While performance was comparable across groups in the gender task, tinnitus patients responded slower than controls in the consonant task, with no effect of target ear. This suggests that tinnitus hampers phonetic perception in speech, while preserving the processing of extralinguistic speaker information. These findings support the growing evidence for speech perception impairments in tinnitus., (© 2021 Elsevier B.V. All rights reserved.)

Chronic tinnitus has been associated with brain structural changes in both the auditory system as well as limbic system. While there is considerable inconsistency across brain structural findings, growing evidence suggests that distress and other non-auditory symptoms modulate effects. In this study we addressed this issue, testing the hypothesis that limbic changes in tinnitus relate to both disease-related distress as well as co-morbid psychopathology. We obtained high-resolution structural magnetic resonance imaging (MRI) scans from a total of 125 subjects: 59 patients with bilateral chronic tinnitus (29 with a co-morbid psychiatric condition, 30 without), 40 healthy controls and 26 psychiatric controls with depression/anxiety disorders (without tinnitus). Voxel-based morphometry with the CAT12 software package was used to analyse data. First, we analysed data based on a 2 × 2 factorial design (tinnitus; psychiatric co-morbidity), showing trend-level effects for tinnitus in ROI analyses of the anterior cingulate cortex and superior/transverse temporal gyri, and for voxel-based analysis in the left parahippocampal cortex. Multiple regression analyses showed that the parahippocampal finding was mostly predicted by tinnitus rather than (dimensional) psychopathology ratings. Comparing only low-distress tinnitus patients (independent of co-morbid conditions) with healthy controls also showed reduced left parahippocampal grey matter. Our findings demonstrate that depression and anxiety (not only subjective distress) are major modulators of brain structural effects in tinnitus, calling for a stronger consideration of psychopathology in future neurobiological and clinical studies of tinnitus., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)

Emotion regulation has an important role in child development and psychopathology. Reappraisal as cognitive regulation technique can be used effectively by children. Moreover, an ERP component known to reflect emotional processing called late positive potential (LPP) can be modulated by children using reappraisal and this modulation is also related to children's emotional adjustment. The present study seeks to elucidate the neural generators of such LPP effects. To this end, children aged 8-14 years reappraised emotional faces, while neural activity in an LPP time window was estimated using magnetoencephalography-based source localization. Additionally, neural activity was correlated with two indexes of emotional adjustment and age. Reappraisal reduced activity in the left dorsolateral prefrontal cortex during down-regulation and enhanced activity in the right parietal cortex during up-regulation. Activity in the visual cortex decreased with increasing age, more adaptive emotion regulation and less anxiety. Results demonstrate that reappraisal changed activity within a frontoparietal network in children. Decreasing activity in the visual cortex with increasing age is suggested to reflect neural maturation. A similar decrease with adaptive emotion regulation and less anxiety implies that better emotional adjustment may be associated with an advance in neural maturation., (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)

We investigated whether and when information conveyed by spoken language impacts on the processing of visually presented objects. In contrast to traditional views, grounded-cognition posits direct links between language comprehension and perceptual processing. We used a magnetoencephalographic cross-modal priming paradigm to disentangle these views. In a sentence-picture verification task, pictures (e.g. of a flying duck) were paired with three sentence conditions: A feature-matching sentence about a duck in the air, a feature-mismatching sentence about a duck in a lake, and an unrelated sentence. Brain responses to pictures showed enhanced activity in the N400 time-window for the unrelated compared to both related conditions in the left temporal lobe. The M1 time-window revealed more activation for the feature-matching than for the other two conditions in the occipital cortex. These dissociable effects on early visual processing and semantic integration support models in which language comprehension engages two complementary systems, a perceptual and an abstract one., (Copyright © 2010 Elsevier Inc. All rights reserved.)

Syntactic priming studies demonstrate that exposure to a particular syntactic structure leads speakers to reproduce the same structure in subsequent utterances. Explanations for this phenomenon rely on either the retrieval of morphosyntactic features associated with the verb in the prime sentence or the preservation of the mapping between message and word sequences in the prime sentence. Two experiments test the featural account of syntactic priming. We used single word primes to investigate the dative alternation in German (Experiment 1) and Dutch (Experiment 2). Native speakers read ditransitive verbs that are restricted either to the prepositional (dative) or double object construction, followed by pictures that can be described with either structure. We find that a single verb in isolation is sufficient to bias speakers' production preferences supporting lexically-driven accounts of syntactic priming.

Objectives: Event-related potential correlates of phonological encoding - as compared with lexical access and semantic categorization - were measured in two studies involving two groups of 14 German and 14 Italian subjects., Methods: A two stimulus reaction time paradigm was used. Stimulus pairs presented one-by-one with 2 s inter-stimulus intervals (ISI) had to be matched with respect to lexical identity (word-picture) in a word comprehension task or with respect to the phonological representative of objects in a rhyming task. A semantic categorization task was added for the Italian sample. In both studies, the EEG was recorded from 26 scalp electrodes according to the 10-20 system. The slow negative potential during the ISI (CNV) was determined as the electrocortical correlate of preparation for and activation of the specific language-related task., Results: In both samples, phonological encoding (rhyming) evoked a more pronounced CNV over the left- compared with the right-frontal area, while less lateralized central dominance of the CNV was found in the word comprehension task. Semantic categorization was accompanied by the least asymmetry of activity., Conclusions: Results indicate that the different degree of asymmetry induced by phonological and semantic processing may be determined from the scalp distribution of slow cortical potentials with cross-lingual reliability.