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2 results on '"Dingfu Xiao"'

1. Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling

Author

Dingfu Xiao, Wenkai Ren, Peng Bin, Shuai Chen, Jie Yin, Wei Gao, Gang Liu, Zi Nan, Xionggui Hu, and Jianhua He

Subjects
Chitosan, IL-17, Intestinal microbiota, mTOR, Nutrition. Foods and food supply, TX341-641
Abstract

This study was conducted to explore the effect of chitosan supplementation on mouse intestinal microbiota and interleukin-17 (IL-17) expression. Chitosan supplementation reduced mouse body weight, associating with change of intestinal microbiota (i.e. lowering the ratio of Firmicutes: Bacteroidetes). In antibiotics treated mice, chitosan supplementation had little effect on mouse body weight. Chitosan supplementation decreased expression of IL-17 in mouse jejunum and inhibited the mTOR pathway. In antibiotics treated mice, chitosan also reduced expression of IL-17 in the jejunum. Activation of mTOR signalling in mouse increased expression of IL-17 in the jejunum in the context of chitosan supplementation. We conclude that chitosan supplementation reduces mouse body weight through the intestinal microbiota, and inhibits intestinal IL-17 expression through the mTOR signalling. The discovery of this study suggests the potentials of chitosan as a functional supplement in intestinal health.

Published
2016
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2. Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling

Author

Zi Nan, Jie Yin, Dingfu Xiao, Wei Gao, Wenkai Ren, Gang Liu, Peng Bin, Shuai Chen, Xionggui Hu, and Jianhua He

Subjects
0301 basic medicine, Intestinal microbiota, medicine.drug_class, Antibiotics, Medicine (miscellaneous), Context (language use), macromolecular substances, Pharmacology, Biology, Microbiology, Jejunum, Chitosan, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, RAR-related orphan receptor gamma, medicine, TX341-641, PI3K/AKT/mTOR pathway, Nutrition and Dietetics, Nutrition. Foods and food supply, technology, industry, and agriculture, FOXP3, equipment and supplies, carbohydrates (lipids), IL-17, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, mTOR, Interleukin 17, Food Science
Abstract

This study was conducted to explore the effect of chitosan supplementation on mouse intestinal microbiota and interleukin-17 (IL-17) expression. Chitosan supplementation reduced mouse body weight, associating with change of intestinal microbiota (i.e. lowering the ratio of Firmicutes: Bacteroidetes). In antibiotics treated mice, chitosan supplementation had little effect on mouse body weight. Chitosan supplementation decreased expression of IL-17 in mouse jejunum and inhibited the mTOR pathway. In antibiotics treated mice, chitosan also reduced expression of IL-17 in the jejunum. Activation of mTOR signalling in mouse increased expression of IL-17 in the jejunum in the context of chitosan supplementation. We conclude that chitosan supplementation reduces mouse body weight through the intestinal microbiota, and inhibits intestinal IL-17 expression through the mTOR signalling. The discovery of this study suggests the potentials of chitosan as a functional supplement in intestinal health.

Published
2016

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