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9 results on '"Dheeraj Bisht"'

1. Potential of particle size less than 15 nm via olfactory region for direct brain delivery via intranasal route

Author

Mayank Handa, Ajit Singh, Dheeraj Bisht, Prashant Kesharwani, and Rahul Shukla

Subjects
Intranasal, Olfactory, Trigeminal, Blood brain barrier, Brain delivery, Medicine
Abstract

Central nervous system-related disorders are very difficult to manage with conventional therapeutics because of the selective and herculean nature of the blood-brain barrier which does not allow easy penetration of drug molecules into the brain. As a result, the efficacy of administered molecule is reduced manifold times, and difficult to ascertain the condition of the patient. An alternative route like the nose to the brain is subjectively being explored to enhance the brain's delivery. Recently various published testimonies have proved the nose to the brain can be an alternative route of administration for effective delivery to the brain. This review majorly highlights the hurdles in the delivery of the nasal route and explores the new areas available for delivery via the concept of particle size below 15 nm, which might penetrate the olfactory bulb via the paracellular spaces present in the olfactory epithelium, which starts from the brain and terminates in the nose. The success of this review might reveal new insights into drug delivery for brain targeting and the necessary delivery mechanism.

Published
2022
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2. Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight.

Author

Dheeraj Bisht, Mohmmad Rashid, Rajeshwar Kamal Kant Arya, Deepak Kumar, Sushil Kumar Chaudhary, Vijay Singh Rana, and Neeraj K. Sethiya

Subjects
Glycyrrhiza glabra, Glycyrrhizin, Flavonoids, Phytoconstituents, Antiinflammatory, Immunomodulatory, Other systems of medicine, RZ201-999
Abstract

Background: Glycyrrhiza glabra L. (G. glabra) commonly known as liquorice is one of the highly exploited and utilized medicinal plant of the world. Since ancient times liquorice is considered as an auspicious and valuable traditional medicine across the world for treatment of various ailments. Method: Several electronic online scientific databases such as Science Direct, PubMed, Scopus, Scifinder, Google Scholar, online books and reports were assessed for collecting information. All the collected information was classified into different sections to meet the objective of the paper. Results: The electronic database search yielded 3908 articles from different countries. Out of them one ninety-eight articles published between 1956 and 2021 were included, corresponding to all detailed review on G. glabra and research on anti-inflammatories, antivirals and immunomodulatory through pre-clinical and clinical models. From all selective area of studies on G. glabra and its bioactive components it was established (including molecular mechanisms) as a suitable remedy as per the current requirement of pandemic situation arise through respiratory tract infection. Conclusion: Different relevant studies have been thoroughly reviewed to gain an insight on utility of liquorice and its bioactive constituents for anti-inflammatories, antivirals and immunomodulatory effects with special emphasized for prevention and treatment of COVID-19 infection with possible mechanism of action at molecular level. Proposed directions for future research are also outlined to encourage researchers to find out various mechanistic targets and useful value added products of liquorice in future investigations.

Published
2022
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3. The chemical constituents and diverse pharmacological importance of Tinospora cordifolia

Author

Priyanka Sharma, Bharat P. Dwivedee, Dheeraj Bisht, Ashutosh K. Dash, and Deepak Kumar

Subjects
Natural product chemistry, Pharmaceutical science, Pharmaceutical chemistry, Tinospora cordifolia, Menispermaceae, Pharmacognostic description, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Tinospora cordifolia is a popular medicinal plant which is used in several traditional medicines to cure various diseases. The common names are Amrita and Guduchi and belong to the family of Menispermaceae. It is considered an essential herbal plant of Indian system of medicine (ISM) and has been used in the treatment of fever, urinary problem, dysentery, skin diseases leprosy, diabetes, and many more diseases. The plant reported containing chemical compound including Alkaloids, Terpenoids, Lignans, Steroids and others that establish the phytochemistry and pharmacological activity of Tinospora cordifolia. The present review highlights the pharmacological importance viz antioxidant activity, antimicrobial activity, antibacterial activity, antifungal activity, anti-diabetic activity, antistress activity, hypolipidaemic effect, hepatic disorder, anticancer anti HIV potential, antiosteoporotic effects, antitoxic effects, wound healing, anticomplementary activity, and immunomodulating activity, systemic infection and Parkinson ̓s disease.

Published
2019
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4. List of contributors

Author

CO Adetunji, null Ankit, Hira Aslam, MO Bamigboye, Najla Bentrad, Swati Bhati, Monika Bhattu, Dheeraj Bisht, Kemal Çetin, Anik Kumar Das, Adil Denizli, Santanu Dhara, Kamal Dua, CA Eziukwu, Hareem Fatima, Anshuman Gaurav, Deepak K Gupta, Humaira Hussain, A Inobeme, Suyambulingam Jone Kirubavathy, Shikha Kapil, Deepika Kathuria, T Kelani, Anglina Kisku, Deepak Kumar, Krishan Kumar, Suneel Kumar, Cansu İlke Kuru, Kalpana Madgula, M Maliki, Padmavati Manchikanti, JT Mathew, Sayan Mukherjee, Gunjan Nagpure, Arunadevi Natarajan, Vanya Nayak, Muhammad Yasin Naz, E Olori, BI Onyeachu, Ajay Pal, Nirmalya Pal, Rishi Paliwal, Mrituanjay D Pandey, Sadanand Pandey, Jhansi Lakshmi Parimi, Shruthy D. Pattathil, Lakshmi Madhuri Peddada, Ekta Poonia, Rishi Raj, Narender Ranga, Rohit Ranga, Nadia Razdan, Soumi Sadhu, Arpit Sand, Akshansh Sharma, Ishan Sharma, Monu Kumar Shukla, Shazia Shukrullah, Anita Singh, Jay Singh, Kshitij RB Singh, Ravindra Pratap Singh, Sachin Kumar Singh, Kunjbihari Sulakhiya, Houcine Touati, Jaya Tuteja, Fulden Ulucan-Karnak, Meenakshi Verma, Aparna Vyas, Yashraj Yadav, and Koray Şarkaya

Published
2023

5. Contributors

Author

Chirom Aarti, Theresa Appiah Agana, Christian Agyare, Rouchan Ali, Racheal Alinaiswe, Helena M. Amaro, Santosh Anand, Joana Assunção, Innocent Ayesiga, Kiran D. Baviskar, Monika Bhardwaj, Samir Bhargava, Koushal Billowria, Dheeraj Bisht, Yaw Duah Boakye, Vivian Etsiapa Boamah, A. Catarina Guedes, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Pooja A. Chawla, Viney Chawla, Vivaldo Gomes da Costa, Sanghita Das, Anindita Dey, Sumanta Dey, Tahereh Farkhondeh, Parul Grover, Ruchi Gupta, Rupa Gupta, Shabnoor Iqbal, Ramachandran Ishwarya, Ashish Jain, Ivan Kahwa, Ameer Khusro, Mohan Lal Kori, Mayank Krishna Kulshrestha, Anoop Kumar, Ram Kumar, Santram Lodhi, Madhumita Majumder, Neelesh Malviya, Sapna Malviya, António B. Mapossa, Rachel Mbabazi, Lovekesh Mehta, Sunita Minz, Prabhakar Mishra, Sharon Nakalema, Ashesh Nandy, Papiya Nandy, Esther Afua Oteng-Amankwah, Umesh Kumar Patil, Madhulika Pradhan, Awdhesh Prasad, Devyani Rajput, R. Ramachandra, Vijay Singh Rana, Muhammad Umar Khayam Sahibzada, Marielena Vogel Saivish, Saeed Samarghandian, Katta Santharam, Rajiv Saxena, Neeraj Kumar Sethiya, Kamal Shah, Tanvir Yusuf Shaikh, Neelima Sharma, Prasanti Sharma, Shubham Sharma, Manindra Mohan Shrivastava, Deependra Singh, Manju Rawat Singh, Alcides Sitoe, S.K. Sukrutha, Marjan Talebi, Mohsen Talebi, Rahul Tiwari, Ritu Tomar, Baskaralingam Vaseeharan, Viroj Wiwanitkit, Krishna Yadav, Sora Yasri, and Fadia S. Youssef

Published
2023

8. Contributors

Author

Amir Hossein Abdolghaffari, Anjana Adhikari-Devkota, Salman Ahmed, Reem Hasaballah Alhasani, Mohammed Alqarni, Norah A. Althobaiti, Renata de Sousa Alves, Rajeshwar K.K. Arya, Mohammad Hossein Asghari, Chundoo B. Azeemah, Joseph I. Azzopardi, Nawshin Baureek, Tapan Behl, Tarun Belwal, Amira Y. Benmelouka, Dhaka R. Bhandari, Dheeraj Bisht, Arti Bisht, Renald Blundell, Anna Blázovics, Hasna Bouhenni, Jacqueline Ramos Machado Braga, Meriem Chafaa, Sharmistha Chatterjee, Zunera Chauhdary, Xiuping Chen, Lei Chen, Ericsson Coy-Barrera, Abhishek K. Das, Hari P. Devkota, Prasanta Dey, Arasana Dhariwal, Sanaa Dilmar A., Koula Doukani, Sumit Durgapal, Daphne Désiré A.-L., Shahira M. Ezzat, Sajad Fakhri, Mohammad Hosein Farzaei, Joomun B. Fatimah-Tuz-Zohra, Aakriti Garg, Noyel Ghosh, Sumit Ghosh, Jalaj K. Gour, Daniel Cordeiro Gurgel, Shokoufeh Hassani, Uday Hossain, Subratty A. Hussein, Shabnoor Iqbal, Arvind Jantwal, Roberta Jeane Bezerra Jorge, Tanuj Joshi, Vijay Juyal, Rahul Kaldate, Gökçe Ş. Karatoprak, Arnab Karmakar, S. Khatoon Khadaroo, Haroon Khan, Abdul H. Khan, Ziyad Khan, Anoop Kumar, Prashant Kumar, Aadesh Kumar, Manish Kumar, Ankit Kumar, Jankee T. Laxmi, Devina Lobine, Meeajan M. Irfaan, Filippo Maggi, Nihal M. El Mahdy, Marwa M. Mahfouz, Mohamad Fawzi Mahomoodally, Ankita Mandal, Aline Diogo Marinho, Harikesh Maurya, Lingchao Miao, Milad Moloudizargari, Saeideh Momtaz, Ghulam Mujtaba Shah, Seyed Mohammad Nabavi, Nouzaifa Nabee, Francisco Assis Nogueira-Junior, Diana Célia Sousa Nunes-Pinheiro, Abhay K. Pandey, Kiran Patni, Pooja Patni, Lokesh Patni, Vinay Pratap, Govind Rajpal, Márcia Maria Vieira Ramos, Harvesh Kumar Rana, Mahendra Rana, Amita J. Rana, Shahid Rasool, Azhar Rasul, Akhtar Rasul, Elodie Rosette M. A.-L., Archana N. Sah, Mohamed A. Salem, Kasturi Sarkar, Ammar S.M. Selles, Muhammad Ajmal Shah, Shahid Shah, Ruchika Sharma, Parames C. Sil, Ana Sanches Silva, João Alison de Moraes Silveira, Amit Kumar Singh, Anita Singh, Manoj K. Singh, Sushil Kumar Singh, Laxman Singh, Leila Soudani, Ipek Süntar, Devesh Tewari, Nidhi Tiwari, Malik Saad Ullah, Hammad Ullah, Jyoti Upadhyay, Mirele da Silveira Vasconcelos, Sandeep Visvarma, Jianbo Xiao, Yixi Xie, Ömer F. Yakıncı, Li Yang, Toorabally B. Zaynab, Haolin Zhang, Francisco Rogênio da Silva Mendes, Dirce Fernandes de Melo, Paulo Carvalho de Paula, Luciana de Siqueira Oliveira, Felipe Domingos de Sousa, Tamiris de Fátima Goebel de Souza, and Juan M. Álvarez-Caballero

Published
2022

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