1. Antiviral activity of substituted homoisoflavonoids on enteroviruses.
- Author
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Tait S, Salvati AL, Desideri N, and Fiore L
- Subjects
- Animals, Antiviral Agents toxicity, Cell Line, Chlorocebus aethiops, Enterovirus physiology, Isoflavones toxicity, Molecular Structure, Virus Replication drug effects, Antiviral Agents chemistry, Antiviral Agents pharmacology, Enterovirus drug effects, Isoflavones chemistry, Isoflavones pharmacology
- Abstract
The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30.
- Published
- 2006
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