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2. Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners

Author

James S. Molton, I. Russel Lee, Denis Bertrand, Ying Ding, Shirin Kalimuddin, David C. Lye, Niranjan Nagarajan, Yunn-Hwen Gan, and Sophia Archuleta

Subjects
Klebsiella pneumoniae, Liver abscess, Microbiome, Genomics, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed. Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient’s clinical isolate was identified in their domestic partner’s stool. Conclusions: This could represent a transmission event or could represent exposure to a common environmental source.

Published
2021
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3. Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma

Author

Kern Rei Chng, Sock Hoai Chan, Amanda Hui Qi Ng, Chenhao Li, Apinya Jusakul, Denis Bertrand, Andreas Wilm, Su Pin Choo, Damien Meng Yew Tan, Kiat Hon Lim, Roy Soetinko, Choon Kiat Ong, Dan G. Duda, Simona Dima, Irinel Popescu, Chaisiri Wongkham, Zhu Feng, Khay Guan Yeoh, Bin Tean Teh, Puangrat Yongvanit, Sopit Wongkham, Vajaraphongsa Bhudhisawasdi, Narong Khuntikeo, Patrick Tan, Chawalit Pairojkul, Joanne Ngeow, and Niranjan Nagarajan

Subjects
Microbiome, Cancer, Cholangiocarcinoma, Liver fluke, Medicine, Medicine (General), R5-920
Abstract

Cholangiocarcinoma (CCA) is the primary cancer of the bile duct system. The role of bile duct tissue microbiomes in CCA tumorigenesis is unestablished. To address this, sixty primary CCA tumors and matched normals, from both liver fluke (Opisthorchis viverrini) associated (OVa, n = 28) and non-O. viverrini associated (non-OVa, n = 32) cancers, were profiled using high-throughput 16S rRNA sequencing. A distinct, tissue-specific microbiome dominated by the bacterial families Dietziaceae, Pseudomonadaceae and Oxalobacteraceae was observed in bile duct tissues. Systemic perturbation of the microbiome was noted in tumor and paired normal samples (vs non-cancer normals) for several bacterial families with a significant increase in Stenotrophomonas species distinguishing tumors vs paired normals. Comparison of parasite associated (OVa) vs non-associated (non-OVa) groups identified enrichment for specific enteric bacteria (Bifidobacteriaceae, Enterobacteriaceae and Enterococcaceae). One of the enriched families, Bifidobacteriaceae, was found to be dominant in the O. viverrini microbiome, providing a mechanistic link to the parasite. Functional analysis and comparison of CCA microbiomes revealed higher potential for producing bile acids and ammonia in OVa tissues, linking the altered microbiota to carcinogenesis. These results define how the unique microbial communities resident in the bile duct, parasitic infections and the tissue microenvironment can influence each other, and contribute to cancer.

Published
2016
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4. Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity

Author

Fei Yao, Jaya P. Kausalya, Yee Yen Sia, Audrey S.M. Teo, Wah Heng Lee, Alicia G.M. Ong, Zhenshui Zhang, Joanna H.J. Tan, Guoliang Li, Denis Bertrand, Xingliang Liu, Huay Mei Poh, Peiyong Guan, Feng Zhu, Thushangi Nadeera Pathiraja, Pramila N. Ariyaratne, Jaideepraj Rao, Xing Yi Woo, Shaojiang Cai, Fabianus H. Mulawadi, Wan Ting Poh, Lavanya Veeravalli, Chee Seng Chan, Seong Soo Lim, See Ting Leong, Say Chuan Neo, Poh Sum D. Choi, Elaine G.Y. Chew, Niranjan Nagarajan, Pierre-Étienne Jacques, Jimmy B.Y. So, Xiaoan Ruan, Khay Guan Yeoh, Patrick Tan, Wing-Kin Sung, Walter Hunziker, Yijun Ruan, and Axel M. Hillmer

Subjects
Biology (General), QH301-705.5
Abstract

Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties. Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians. Rearrangements were enriched in open chromatin and shaped by chromatin structure. We identified seven rearrangement hot spots and 136 gene fusions. In three out of 100 GC cases, we found recurrent fusions between CLDN18, a tight junction gene, and ARHGAP26, a gene encoding a RHOA inhibitor. Epithelial cell lines expressing CLDN18-ARHGAP26 displayed a dramatic loss of epithelial phenotype and long protrusions indicative of epithelial-mesenchymal transition (EMT). Fusion-positive cell lines showed impaired barrier properties, reduced cell-cell and cell-extracellular matrix adhesion, retarded wound healing, and inhibition of RHOA. Gain of invasion was seen in cancer cell lines expressing the fusion. Thus, CLDN18-ARHGAP26 mediates epithelial disintegration, possibly leading to stomach H+ leakage, and the fusion might contribute to invasiveness once a cell is transformed.

Published
2015
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5. Liste des auteurs

Author

Aquino, Jean-Pierre, primary, Cudennec, Tristan, additional, Barthélémy, Lucette, additional, Andrieu, Sandrine, additional, Ankri, Joël, additional, Arrouy, Laurence, additional, Aubert, Lucie, additional, Baranes, Joseph John, additional, Barret, Béatrice, additional, Baudry, Élodie, additional, Bayle, Catherine, additional, Beaune, Sébastien, additional, Beguin, Anne-Marie, additional, Beguin, Mathilde, additional, Bérard, Alain, additional, Blanckaert, Antonin, additional, Zamponi, Dominique Bonnet, additional, Bouaziz, Walid, additional, Bouccara, Didier, additional, Bouchara, Julie, additional, Brieu, Marie-Anne, additional, Bula, Christophe, additional, Caillet, Philippe, additional, Cambon, Laurent, additional, Caron-Thibault, Gauthier, additional, Carrère, Barbara, additional, Chapon, Pierre-Marie, additional, Charras, Kevin, additional, Chassagne, Philippe, additional, Chevallier, Anita, additional, Chevrier, Roland, additional, Coconnier, Andrée, additional, Cohen, Marc, additional, Curatolo, Niccolo, additional, Daire, Rodolphe, additional, De Malherbe, Adèle, additional, de Rotrou, Jocelyne, additional, Dejardin, Philippe, additional, Demory, Mathilde, additional, Denis, Bertrand, additional, Derville, Sandrine, additional, Desana, Marie-Odile, additional, Driessen, Élodie, additional, Duportet, Bernard, additional, Dupré-Lévêque, Delphine, additional, Dupuy, Charlotte, additional, Durpoix, Catherine, additional, Eclancher, Sandra, additional, Forestier, Begum Errol, additional, Farag, Laurent, additional, Fauchard, Gwenaelle, additional, Faucher, Nathalie, additional, Feteanu, Dorin, additional, Forestier, Romain, additional, Forette, Françoise, additional, Françon, Alain, additional, Fuchs, Marie-Françoise, additional, Fulop, Tamas, additional, Gavazzi, Gaëtan, additional, Geoffroy, Marie, additional, Gervais, Xavier, additional, Giron, Paule, additional, Godart, Marie-Christine, additional, Guérin, Oliver, additional, Guillet, Philippe, additional, Guitton, Claire, additional, Gzil, Fabrice, additional, Halimi, Didier, additional, Harboun, Marc, additional, Hautin, Pascale, additional, Hervy, Bernard, additional, Houles, Mathieu, additional, Hubert, Sidonie, additional, Hugonot-Diener, Laurence, additional, Hugues, Julie, additional, Hugues, Philippe, additional, Jacquin-Mourain, Nicole, additional, Jeandel, Claude, additional, Jothy, Anne-Catherine, additional, Kaltenbach, Georges, additional, Lapierre, Vincent, additional, Lefebvre, Pierre-Olivier, additional, Legrain, Sylvie, additional, Le Guen, Julien, additional, Lemaire, Aurélie, additional, Lesure, Christine, additional, Madjlessi, Arach, additional, Malaquin-Pavan, Évelyne, additional, Manciaux, Marie-Agnès, additional, Martin, Marie-Laure, additional, Maubourguet, Nathalie, additional, Menecier, Pascal, additional, Mohebi, Alexis, additional, Morvillers, Jean-Manuel, additional, Motte, Valérie, additional, Moulias, Sophie, additional, Garcia, Araceli Muela, additional, Muller, Florence, additional, Noaillon, Mathilde, additional, Nogues, Michel, additional, Nouvel, Fabrice, additional, Paccard, Delphine, additional, Paillaud, Éléna, additional, Péan, Hélène, additional, Pedepeyrau, Cécilia, additional, Pigné, Étienne, additional, Pin, Stéphanie, additional, Platel, Hervé, additional, Prate, Frédéric, additional, Rapagnani, Giuliana, additional, Raynaud-Simon, Agathe, additional, Reguer, Daniel, additional, Renkes, Jacqueline, additional, Reznikoff, Valérie, additional, Robert, Philippe, additional, Robine, Jean-Marie, additional, Rogez, Élisabeth, additional, Rolland, Yves, additional, Rothan-Tondeur, Monique, additional, Sacco, Guillaume, additional, Saint-Gaudens, Pascale, additional, Salord, Jean-Claude, additional, Schmitt, Elisé, additional, Sifaoui, Brigitte, additional, Somme, Dominique, additional, Sophie, Lartigue, additional, Suzanne, Olivier, additional, Teillet, Laurent, additional, Teixeira, Antonio, additional, Thillard, Anne Lyse, additional, Tifratène, Karim, additional, Trotet, Sarah, additional, Vellas, Bruno, additional, Verny, Christiane, additional, Verny, Marc, additional, Viatour, Géraldine, additional, Vilaine, Ève, additional, Villez, Marion, additional, Vincent, Hélène, additional, and Vogel, Thomas, additional

Published
2016
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