1. Reprogramming microorganisms for the biosynthesis of astaxanthin via metabolic engineering
- Author
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Fenghong Huang, Xia Wan, Dan Chen, Lin Su, Yangmin Gong, Gabriel Moncalián, Zhu Hangzhi, Chen Wenchao, Xue-Rong Zhou, Deng Qianchun, Chinese Academy of Agricultural Sciences, and Ministry of Science and Technology of the People's Republic of China
- Subjects
0106 biological sciences ,0301 basic medicine ,Microorganism ,Xanthophylls ,Biology ,01 natural sciences ,Biochemistry ,Metabolic engineering ,03 medical and health sciences ,chemistry.chemical_compound ,Synthetic biology ,Biosynthesis ,Astaxanthin ,business.industry ,Cell Biology ,Carotenoids ,Biosynthetic Pathways ,Biotechnology ,030104 developmental biology ,chemistry ,business ,Reprogramming ,010606 plant biology & botany - Abstract
There is an increasing demand for astaxanthin in food, feed, cosmetics and pharmaceutical applications because of its superior anti-oxidative and coloring properties. However, naturally produced astaxanthin is expensive, mainly due to low productivity and limited sources. Reprogramming of microorganisms for astaxanthin production via metabolic engineering is a promising strategy. We primarily focus on the application of synthetic biology, enzyme engineering and metabolic engineering in enhancing the synthesis and accumulation of astaxanthin in microorganisms in this review. We also discuss the biosynthetic pathways of astaxanthin within natural producers, and summarize the achievements and challenges in reprogramming microorganisms for enhancing astaxanthin production. This review illuminates recent biotechnological advances in microbial production of astaxanthin. Future perspectives on utilization of new technologies for boosting microbial astaxanthin production are also discussed., This work was supported by the Chinese Academy of Agricultural Sciences [grant numbers Y2020XK25, CAAS-XTCX2018020-7 and CAAS-ASTIP-2016-OCRI], the “3551” Optics Valley Talent Schema [grant number K159] and the Ministry of Science and Technology of the China [grant number 2016YFD0501209].
- Published
- 2021