1. Influence of ethanol on gastric absorption and metabolism of albendazole and mebendazole.
- Author
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Justel A, Alvarez AI, Alonso ML, del Estal JL, Villaverde C, Barrio JP, and Prieto JG
- Subjects
- Animals, Dose-Response Relationship, Drug, Gastric Mucosa drug effects, Gastric Mucosa metabolism, Intestinal Absorption drug effects, Liver drug effects, Liver metabolism, Male, Rats, Rats, Wistar, Albendazole pharmacokinetics, Ethanol pharmacology, Mebendazole pharmacokinetics
- Abstract
The effect of ethanol administration on gastric absorption in rats of two benzimidazole derivatives has been studied. The ethanol administration was carried out as both acute (5%, 10% and 15% w/v of ethanol in the perfusion solution), and chronic (15, 30 and 120 days) forms. Two benzimidazole derivatives were used: albendazole (ABZ) and mebendazole (MBZ). The administration of ethanol did not affect the kinetic mechanism of the absorption process (simple diffusion) but the absorption rate decreased in all treatments except in 5% acute ethanol, presumably due to the improved solubility of the drugs. Plasma, bile and liver levels after gastric perfusion suggest a possible interference of ethanol metabolism with drug hepatic metabolism.
- Published
- 1994
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