17 results on '"De Giorgio, F."'
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2. List of contributors
- Author
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Arbizzani, C., primary, Castillo, E. Cabrera, additional, Danzer, M.A., additional, De Giorgio, F., additional, Fetcenko, M., additional, Garche, J., additional, Goldbach, T., additional, Grazioli, D., additional, Hauser, A., additional, Helms, H., additional, Herrmann, F., additional, Huber, C., additional, Kämper, C., additional, Karden, E., additional, Kim, H., additional, Kintner-Meyer, M.C., additional, Koch, J., additional, Kuhn, R., additional, Kurzweil, P., additional, Lambrecht, U., additional, Liebau, V., additional, Linse, C., additional, Lunz, B., additional, Maglia, F., additional, Mastragostino, M., additional, Moseley, P.T., additional, Müller, M., additional, Oh, S.-M., additional, Perner, A., additional, Püttner, A., additional, Rothfuss, F., additional, Salvadori, A., additional, Sauer, D.U., additional, Schott, B., additional, Scrosati, B., additional, Sun, Y.-K., additional, Vetter, J., additional, Viswanathan, V.V., additional, and Zelinsky, M., additional
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- 2015
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3. Battery parameters for hybrid electric vehicles
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F. De Giorgio, Catia Arbizzani, Marina Mastragostino, B. Scrosati, J. Garche, W. Tillmetz, Arbizzani, C, De Giorgio, F, and Mastragostino, M
- Subjects
High voltage cathode ,Supercapacitor ,Battery (electricity) ,Engineering ,business.product_category ,business.industry ,Electrical engineering ,Automotive engineering ,HEV ,Hardware_GENERAL ,Electric vehicle ,battery ,Fuel cells ,high voltage cathode ,business - Abstract
This chapter discusses the evaluation of the key parameters of lithium-ion batteries for power assist and plug-in hybrid electric vehicle applications on the basis of reference tests set up by the US Advanced Battery Consortium–Department of Energy; a battery case study is used to highlight the analysis procedure. The chapter then briefly summarizes the main characteristics of lithium-ion batteries already on the market and under development, with emphasis also given to the safety of each battery-chemistry. The use of supercapacitors (ultracapacitors) in parallel with the batteries to increase both performance and battery life is also discussed, and limits and future developments of lithium-ion batteries and of supercapacitors are included. Finally, a short discussion is provided about the on-road transportation of the future.
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- 2015
4. Comprehensive evaluation of the pharmacological and toxicological effects of γ-valerolactone as compared to γ-hydroxybutyric acid: Insights from in vivo and in silico models.
- Author
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Arfè R, Bilel S, Tirri M, Corli G, Bergamin E, Serpelloni G, Bassi M, Borsari M, Boccuto F, Bernardi T, Caruso L, Alkilany AM, Rachid O, Botrè F, De-Giorgio F, and Marti M
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- Male, Mice, Animals, Hydroxybutyrates, Computer Simulation, Sodium Oxybate
- Abstract
Γ-valerolactone (GVL), marketed online as "Tranquilli-G" and "excellent Valium", is used as a legal substitute for γ-hydroxybutyric acid (GHB); however, until now, GVL has only been connected to one Drug-Facilitated Sexual Assault (DFSA) case. Moreover, the pharmaco-toxicological effects of GVL are poorly studied. The aim of this study was to investigate the 1) in vivo effects of gavage administration of GVL (100-3000 mg/kg) on neurological (myoclonia, convulsions), sensorimotor (visual, acoustic, and overall tactile) responses, righting reflex, thermoregulation, motor activity (bar, drag, and accelerod test) and cardiorespiratory changes (heart rate, breath rate, oxygen saturation, and pulse distension) in CD-1 male mice and the 2) in silico ADMET profile of GVL in comparison to GHB and the open active form γ-hydroxyvaleric acid (GHV). The present study demonstrates that GVL inhibits, in a dose-dependent manner, sensorimotor and motor responses and induces cardiorespiratory depression (at a dose of 3000 mg/kg) in mice. The determination of the ED
50 in sensorimotor and motor responses revealed that GVL is about 4-5 times less potent than GHB. In silico prediction of ADMET profiles revealed toxicokinetic similarities between GHB and GHV, and differences with GVL. These results suggest that GVL could be used as a substitute for GHB and should be added to forensic toxicology screenings., Competing Interests: Declaration of Competing Interest Declarations of interest: none., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)- Published
- 2023
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5. Atlantoaxial Joint Distraction and Fusion with DTRAX Intra-Articular Cages: A Cadaveric Feasibility Study and Review of the Pertinent Literature.
- Author
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Rapisarda A, Pennisi G, Montano N, Della Pepa GM, Ricciardi L, De-Giorgio F, Visocchi M, Olivi A, and Polli FM
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- Adult, Cadaver, Cervical Vertebrae surgery, Feasibility Studies, Humans, Tomography, X-Ray Computed, Atlanto-Axial Joint physiology, Atlanto-Axial Joint surgery, Platybasia, Spinal Fusion methods
- Abstract
Purpose: Atlantoaxial joint distraction is a key procedure for the treatment of selected patients affected by basilar invagination (BI). In recent years, several authors have reported various techniques of distraction and fixation of the C1-C2 joint using different types of intra-articular spacers, with or without posterior fixation. We review the pertinent literature and propose a feasibility study on the use of a new device for the distraction of the C1-C2 joint aimed to the descent of the dens out of the foramen magnum suggesting its application on selected cases of BI., Methods: The GL-DTRAX Cervical Cage-SE is a cage approved by the Food and Drug Administration for distraction and fixation of subaxial cervical spine. Five adult cadaveric specimens were dissected surgically to evaluate the feasibility of DTRAX insertion inside the C1-C2 joint through a posterior approach., Results: The cages were uneventfully set into the C1-C2 intra-articular space of all samples without the need to sacrifice C2 nerve roots and ganglia. Postoperative cervical computed tomography scanning confirmed the correct fitting of the devices in every sample., Conclusions: This cadaveric study highlights the feasibility of the DTRAX cage as a C1-C2 intra-articular device producing a substantial distraction of atlantoaxial complex and suggesting a possible therapeutic role in selected cases of BI., (Copyright © 2022. Published by Elsevier Inc.)
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- 2022
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6. Ethanol enhanced MDPV- and cocaine-induced aggressive behavior in mice: Forensic implications.
- Author
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De-Giorgio F, Bergamin E, Bilel S, Tirri M, Arfè R, Marchetti B, Corli G, Serpelloni G, and Marti M
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- Aggression, Animals, Benzodioxoles, Dose-Response Relationship, Drug, Ethanol, Male, Mice, Pyrrolidines, Cocaine
- Abstract
Background: Reports concerning the causal link between aggressive behavior and use and abuse of different substances (i.e., alcohol, MDPV) can be found in the literature. Nonetheless, the topic concerning the effects of acute ethanol administration on MDPV and cocaine induced aggressive behavior has yet to be thoroughly investigated. The aim of this study was to investigate such synergistic effects., Materials and Methods: A total of 360 male mice were employed in the study. Ethanol was diluted with saline solution and administered 10 min before MDPV or cocaine injection via oral gavage needles. Similarly, MDPV and cocaine were dissolved in saline solution and administered by intraperitoneal injection. Different associations of specific drug doses were then tested. To investigate the acute effects of MDPV and cocaine and their interaction with ethanol on aggression in mice, a resident-intruder test was used., Results: Ethanol alone was ineffective at dosages of 0.05 g/kg and 0.25 g/kg but increased the aggressiveness of the mice at 0.125 g/kg. Similarly, the injection of both cocaine alone and MDPV alone did not significantly increase the aggressiveness of the mice; conversely, the combination of ethanol and cocaine and ethanol and MDPV enhanced aggression at specific ethanol dosages (0.05 g/kg and 0.125 g/kg)., Conclusion: This study demonstrated that acute ethanol administration enhances MDPV- and cocaine-induced aggressive behavior in mice. This aggressive response is particularly enhanced when MDVP and cocaine are coupled with specific ethanol dosages, proving that psychostimulant drugs may act synergistically under certain conditions., (Copyright © 2021. Published by Elsevier B.V.)
- Published
- 2021
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7. A 360° Approach to the Craniovertebral Junction in a Cadaveric Laboratory Setting: Historical Insights, Current, and Future Perspectives in a Comparative Study.
- Author
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Signorelli F, Olivi A, De Giorgio F, Pascali VL, and Visocchi M
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- Atlanto-Occipital Joint anatomy & histology, Cadaver, Cervical Atlas anatomy & histology, Cranial Fossa, Posterior anatomy & histology, Cranial Fossa, Posterior surgery, Cranial Nerves anatomy & histology, Dissection, Humans, Mouth, Nasal Cavity, Natural Orifice Endoscopic Surgery, Neurosurgical Procedures methods, Occipital Bone anatomy & histology, Odontoid Process, Vertebral Artery anatomy & histology, Atlanto-Occipital Joint surgery, Cervical Atlas surgery, Neuroendoscopy methods, Neuronavigation methods, Occipital Bone surgery
- Abstract
Background: We herein outline the experience matured in our equipped Cranio-Vertebral Junction Laboratory for anatomic dissection., Methods: An extreme lateral approach (ELA) was performed on 4 fresh cadavers and submandibular approach was performed on 5. An endoscope and navigation-assisted far lateral approach (FLA) was performed in 5 injected specimens. In these specimens, a transoral approach was also performed, as well as a neuronavigation-assisted comparison between transoral and transnasal explorable distances., Results: As calculated with neuronavigation, statistically significant differences both in the explored craniocaudal (P = 0.003) and lateral (P = 0.008) distances were observed between the transoral approach and endoscopic endonasal approach. In FLA, neuronavigation facilitated identification and partial removal of the occipital condyle; in one case, during endoscopic intradural exploration, tearing of the emerging roots of the 11th cranial nerve occurred. In ELA, the site where the accessory nerve pierces into the sternocleidomastoid muscle was found at a distance from the tip of the mastoid between 3 and 4 cm., Conclusions: During dissections, as in the clinical setting, endoscope and image guidance give the surgeon a constant orientation, increasing the accuracy and the safety of the approach. Nonetheless, the encumbrance of the endoscope could represent a limit in deep and narrow corridors as those running across the craniovertebral junction, especially in "oblique" FLA and ELA, in which the surgical target is often hidden by a delicate tangle of nerves and vessels. Its use appears more suitable and safer in "straight" approaches as transoral and transnasal in which there are no neurovascular structures interposed., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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8. A case of Jack Russel Terrier scavenging: Images and three dimensional models for forensic interpretation.
- Author
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De-Giorgio F, Grassi S, and Berketa JW
- Subjects
- Accidental Falls, Adult, Animals, Facial Injuries etiology, Facial Injuries pathology, Forensic Dentistry, Forensic Pathology, Humans, Male, Neck Injuries etiology, Neck Injuries pathology, Photogrammetry, Skull Fractures pathology, Subarachnoid Hemorrhage pathology, Bites and Stings pathology, Computer Simulation, Dogs, Feeding Behavior, Imaging, Three-Dimensional, Tooth diagnostic imaging
- Abstract
Distinguishing between ante-mortem and post-mortem domestic dog injuries is fundamental in order to correctly find the cause of the death. Although fatal aggressions are chiefly perpetrated by pit bull-type dogs, small dogs are responsible for a significant share of animal bites and can cause high-degree injuries. On the other side, indoor and outdoor scavenging can hinder forensic investigation, consuming parts of the body where crucial forensic features like bruises and wounds have been inflicted. In the case we present, a man died after falling down his house stairs because of a traumatic intracranial haemorrhage. His dog, a Jack Russel Terrier, scavenged a significant portion of his facial superficial and deep tissues, suggesting to the investigators the hypothesis of a brutal aggression. In this paper, we showed how the application of advanced 3D processing and modelling techniques can give a crucial contribution to detect the injuries certainly caused by animal teeth., (Copyright © 2019 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.)
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- 2019
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9. Excavated pulmonary lesions: differential diagnosis in a health-care worker.
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Trecarichi EM, Spagnolo A, De-Giorgio F, Pirronti T, Inzani F, and Vetrugno G
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- Diagnosis, Differential, Female, Humans, Middle Aged, Nasal Polyps drug therapy, Pneumonia, Lipid etiology, Pneumonia, Lipid diagnosis
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- 2017
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10. Myocardial bridging and ecstasy: A fatal combination involving a 22year-old male.
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Zaami S, De-Giorgio F, Marinelli E, Pellegrini M, Pichini S, and Busardò FP
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- Fatal Outcome, Humans, Male, Young Adult, Hallucinogens toxicity, Myocardial Bridging chemically induced, Myocardial Bridging pathology, N-Methyl-3,4-methylenedioxyamphetamine toxicity
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- 2016
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11. Myocardial bridging and sudden cardiac death: is the actual classification exhaustive?
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De Giorgio F, Grassi VM, Polacco M, Pascali VL, d'Aloja E, and Arena V
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- Adult, Aged, 80 and over, Autopsy, Death, Sudden, Cardiac etiology, Female, Humans, Male, Myocardial Bridging diagnosis, Myocardial Bridging mortality, Death, Sudden, Cardiac pathology, Myocardial Bridging complications, Myocardium pathology
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- 2014
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12. Formation of the inflammasome in acute myocarditis.
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Toldo S, Kannan H, Bussani R, Anzini M, Sonnino C, Sinagra G, Merlo M, Mezzaroma E, De-Giorgio F, Silvestri F, Van Tassell BW, Baldi A, and Abbate A
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- Acute Disease, Adult, Female, Humans, Male, Middle Aged, Myocarditis pathology, Inflammasomes metabolism, Inflammation Mediators metabolism, Myocarditis diagnosis, Myocarditis metabolism
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- 2014
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13. Screening for exogenous androgen anabolic steroids in human hair by liquid chromatography/orbitrap-high resolution mass spectrometry.
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Strano-Rossi S, Castrignanò E, Anzillotti L, Odoardi S, De-Giorgio F, Bermejo A, and Pascali VL
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- Down Syndrome metabolism, Down Syndrome pathology, Forensic Toxicology, Humans, Male, Mass Spectrometry, Testosterone analogs & derivatives, Testosterone analysis, Young Adult, Chromatography, High Pressure Liquid, Hair chemistry, Steroids analysis
- Abstract
A method for the screening of various anabolic steroids and their esters in human hair, based on liquid-chromatography-high resolution mass spectrometry using an Exactive benchtop Orbitrap mass spectrometer, has been set up and validated. This method involved methanolic incubation of 30 mg of hair and analysis of the relevant extract in HPLC using a C18 column. The mass detector, with nominal resolving power of 100,000, operated in full scan mode in APCI under positive ionization mode. Analytes were identified by exact mass, correspondence of isotopic cluster and retention times. The limits of detection obtained varied from 10 to 50 pg mg(-1), and limits of quantitation were 0.5 ng mg(-1) for all compounds. The method was linear for all analytes in the ranges from the LOQ to 6 ng mg(-1), giving correlation coefficients >0.99 for all analytes. Also accuracy (intended as %E) and repeatability (%CV) were always lower than 15%. Specificity was assessed by analysing ten blank samples and fifteen samples from polidrug abusers. This method was applied to a real-life case, resulting in the identification of testosterone undecanoate in the hair of a suspect. The analyte identity was confirmed by the analysis of its in-source fragmentation and comparison to a certified standard. Thanks to the scan acquisition, this method also enables retrospective re-analysis of the acquired datafile in case a further analyte needs to be screened., (Copyright © 2013 Elsevier B.V. All rights reserved.)
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- 2013
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14. Causation or coincidence? A case of sudden death due to spontaneous coronary artery dissection in presence of myocardial bridging.
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De-Giorgio F, Grassi VM, Abbate A, d'Aloja E, and Arena V
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- Adult, Female, Humans, Vascular Diseases complications, Vascular Diseases diagnosis, Coronary Vessel Anomalies complications, Coronary Vessel Anomalies diagnosis, Death, Sudden, Cardiac, Myocardial Bridging complications, Myocardial Bridging diagnosis, Vascular Diseases congenital
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- 2012
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15. An unusual cause of fatal pulmonary embolism.
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De Giorgio F, Abbate A, Zoccai GB, Pascali VL, d'Aloja E, Capelli A, and Arena V
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- Aged, Autopsy, Fatal Outcome, Humans, Male, Arthritis, Gouty complications, Pulmonary Embolism etiology
- Abstract
We report on a case of a fatal pulmonary embolism--an unexpected finding at autopsy of a 71-year-old man who had suffered from severe erosive gouty arthritis. Using morphological findings, medical history and histopathological results, we show the potentially devastating complications of this fairly common medical condition, occurring as a result of massive bone marrow erosion and detachment and finally leading to embolization of the lungs.
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- 2007
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16. Right atrium tear as cause of death after blunt chest trauma.
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De Giorgio F, Abbate A, Capelli A, and Arena V
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- Humans, Male, Middle Aged, Seat Belts adverse effects, Death, Sudden etiology, Heart Atria injuries, Heart Injuries complications, Wounds, Nonpenetrating complications
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- 2006
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17. Increased apoptosis in remote non-infarcted myocardium in multivessel coronary disease.
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Biondi-Zoccai GG, Abbate A, Vasaturo F, Scarpa S, Santini D, Leone AM, Parisi Q, De Giorgio F, Bussani R, Silvestri F, Baldi F, Biasucci LM, and Baldi A
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- Autopsy, Humans, Immunohistochemistry, Male, Myocardial Infarction mortality, Ventricular Remodeling, Apoptosis, Coronary Disease pathology, Coronary Vessels pathology, Myocardial Infarction pathology
- Abstract
Background: Multivessel coronary disease after myocardial infarction is a major risk factor for unfavorable cardiac remodeling and death due to pump failure, but underlying pathophysiologic mechanisms are still uncompletely established. Post-infarction myocardial apoptosis has been recently implicated as a cause of ongoing cell loss leading to cardiac failure. Our aim was to assess the role of post-infarction myocardial apoptosis and pro-apoptotic factor expression in the non-infarcted remote myocardium of subjects with multivessel coronary disease., Methods: Twenty-one males dying after recent myocardial infarction with permanent occlusion of the infarct-related artery were selected at autopsy. Apoptosis was assessed at viable myocardial regions remote from infarction by co-staining for in situ end-labeling of DNA fragmentation and cleaved caspase-3. Expression of pro-apoptotic factor bax and hypoxia-induced factor-1alpha was evaluated by immunohistochemistry., Results: Subjects with multivessel disease (N=11) showed a significantly two-fold higher myocardial apoptosis in comparison to subjects with single vessel disease (N=10) (0.9% vs. 0.5%, p=0.013). Similarly, myocardial bax expression was increased in patients with multivessel disease (3.0% vs. 1.4%, p=0.029). Stratification for the number of diseased coronary vessels confirmed the association between extent of coronary disease and apoptotic rates (p=0.022). Even in subjects dying over 30 days after infarction multivessel disease remained predictive of enhanced myocardiocyte apoptosis at remote regions (p=0.033)., Conclusions: Post-infarction myocardial apoptosis and bax expression in remote left ventricular regions are significantly increased in male patients with multivessel coronary disease in comparison to those with isolated infarct-related artery occlusion. These findings suggest that apoptotic cell loss in the viable non-infarcted myocardium, possibly due ongoing ischemia, may play a relevant role in the unfavorable clinical course typical of multivessel disease after myocardial infarction.
- Published
- 2004
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