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Your search keyword '"Davide Ruffoni"' showing total 4 results
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4 results on '"Davide Ruffoni"'

1. Joining soft tissues to bone: Insights from modeling and simulations

Author

Alexandra Tits and Davide Ruffoni

Subjects
Enthesis, Bone-tendon interface, Modeling, Computer simulations, Fibrocartilage, Gradients, Diseases of the musculoskeletal system, RC925-935
Abstract

Entheses are complex multi-tissue regions of the musculoskeletal system serving the challenging task of connecting highly dissimilar materials such as the compliant tendon to the much stiffer bone, over a very small region. The first aim of this review is to highlight mathematical and computational models that have been developed to investigate the many attachment strategies present at entheses at different length scales. Entheses are also relevant in the medical context due to the high prevalence of orthopedic injuries requiring the reattachment of tendons or ligaments to bone, which are associated with a rather poor long-term clinical outcome. The second aim of the review is to report on the computational works analyzing the whole tendon to bone complex as well as targeting orthopedic relevant issues. Modeling approaches have provided important insights on anchoring mechanisms and surgical repair strategies, that would not have been revealed with experiments alone. We intend to demonstrate the necessity of including, in future models, an enriched description of enthesis biomechanical behavior in order to unravel additional mechanical cues underlying the development, the functioning and the maintaining of such a complex biological interface as well as to enhance the development of novel biomimetic adhesive, attachment procedures or tissue engineered implants.

Published
2021
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3. Local adaptation of bone micro-structure and canal network to tendon insertion investigated by image-based micro-FE simulations

Author

Pierre Drion, Alexandra Tits, Peter Varga, Erwan Plougonven, Justin Fernandez, Davide Ruffoni, Jean-François Kaux, Timothy Volders, and G. Harry van Lenthe

Subjects
Materials science, lcsh:Diseases of the musculoskeletal system, Endocrinology, Diabetes and Metabolism, Micro computed tomography, Canal network, Micro structure, Tendon, medicine.anatomical_structure, medicine, Orthopedics and Sports Medicine, lcsh:RC925-935, Image based, Biomedical engineering, Local adaptation
Published
2020

4. Finite Element Analysis in Bone Research: A Computational Method Relating Structure to Mechanical Function

Author

Harry van Lenthe and Davide Ruffoni

Subjects
Materials science, business.industry, media_common.quotation_subject, Osteoporosis, Structure (category theory), Structural engineering, Materials design, medicine.disease, Finite element method, medicine.anatomical_structure, Osteocyte, Fracture (geology), medicine, Hierarchical organization, Function (engineering), business, media_common
Abstract

Bone is probably the most frequently investigated biological material and finite element analysis (FEA) is the computational tool most commonly used for the analysis of bone biomechanical function. FEA has been used in bone research for more than 30 years and has had a substantial impact on our understanding of the complex behavior of bone. Bone is structured in a hierarchical way covering many length scales and this chapter reflects this hierarchical organization. In particular, the focus is on the applications of FEA for understanding the relationship between bone structure and its mechanical function at specific hierarchical levels. Depending on the hierarchical level, different issues have been investigated with FEA ranging from more clinically oriented topics related to bone quality (e.g., predicting bone strength and fracture risk) to more fundamental problems dealing with the mechanical aspects of biological processes (e.g., stress and strain around osteocyte lacunae) as well as with the micromechanical behavior of bone at its ultrastructure. A better understanding of the relationship between structure and mechanical function is expected to be important for the current trends in (bio)materials design, where the structure of biological materials is considered as a possible source of inspiration, as well as for more successful approaches in the prevention and treatment of age- and disease-related fractures.

Published
2011
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