1. Extracellular Vesicle Biogenesis in Cancer
- Author
-
Stephanie N. Hurwitz and David G. Meckes
- Subjects
0301 basic medicine ,Cell ,Cancer ,Context (language use) ,Extracellular vesicle ,Biology ,medicine.disease ,Extracellular vesicles ,Cell biology ,Human tumor ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,Biogenesis - Abstract
Extracellular vesicles (EVs) represent a broad collection of membrane-enclosed sacs released from cells that contain biologically active cargo and cell type–specific and disease type–specific molecular information. Furthermore, EVs have been demonstrated to perpetuate the pathogenesis and progression of disease through manipulation of cells in the surrounding microenvironment. Based on the unique properties of EVs, there is tremendous interest in developing EV-based diagnostic and therapeutic platforms for cancer and many other diseases. However, before the full medical utility of EVs can be reached, a better understanding of mechanisms driving EV biogenesis must be obtained. Here, we will highlight the current understanding of EV biogenesis in the context of cancer, discuss recent advances in the field, and provide evidence for the utility of human tumor viruses in studying EV biogenesis and trafficking.
- Published
- 2018