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Your search keyword '"D. Sudhaker Rao"' showing total 3 results
Start Over Author "D. Sudhaker Rao" Publisher elsevier
3 results on '"D. Sudhaker Rao"'

1. Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone

Author

Kumaran Sundaram, Yuvaraj Sambandam, Srinivasan Shanmugarajan, D. Sudhaker Rao, and Sakamuri V. Reddy

Subjects
Paget's disease of bone, Osteoclast, MVNP, DAP12, SIRPβ1, Diseases of the musculoskeletal system, RC925-935
Abstract

Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP) has been shown to induce pagetic osteoclasts (OCLs). However, the molecular mechanisms underlying MVNP stimulation of OCL differentiation in the PDB are unclear. We therefore determined the MVNP regulated gene expression profiling during OCL differentiation. Agilent microarray analysis of gene expression identified high levels of SIRPβ1 (353-fold) expression in MVNP transduced human bone marrow mononuclear cells stimulated with RANKL. Real-time PCR analysis further confirmed that MVNP alone upregulates SIRPβ1 mRNA expression in these cells. Also, bone marrow mononuclear cells derived from patients with PDB showed high levels of SIRPβ1 mRNA expression compared to normal subjects. We further show that MVNP increases SIRPβ1 interaction with DAP12 adaptor protein in the presence and absence of RANKL stimulation. shRNA knockdown of SIRPβ1 expression in normal human bone marrow monocytes decreased the levels of MVNP enhanced p-Syk and c-Fos expression. In addition, SIRPβ1 knockdown significantly decreased MVNP stimulated dendritic cell–specific transmembrane protein (DC-STAMP) and connective tissue growth factor (CTGF) mRNA expression during OCL differentiation. Furthermore, we demonstrated the contribution of SIRPβ1 in MVNP induced OCL formation and bone resorption. Thus, our results suggest that MVNP modulation of SIRPβ1 provides new insights into the molecular mechanisms which control high bone turnover in PDB.

Published
2017
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2. Clinical Presentation of Primary Hyperparathyroidism

Author

Ambrish Mithal, Luiz Griz, Saroj Kanta Mishra, Yifan Shi, Geísa M. Macedo, John P. Bilezikian, D. Sudhaker Rao, Gustav Celdas, Shonni J. Silverberg, Francisco Bandeira, Xun-wu Meng, and Cristina Bandeira

Subjects
Pathology, medicine.medical_specialty, Hyperparathyroidism, endocrine system diseases, business.industry, Osteitis fibrosa cystica, Physiology, medicine.disease, Asymptomatic, Malnutrition, Parathyroid carcinoma, medicine, Vitamin D and neurology, Parathyroid hormone secretion, medicine.symptom, business, Primary hyperparathyroidism
Abstract

The pattern of presentation of hyperparathyroidism has changed in the West such that nearly 70–80% patients are asymptomatic and do not usually suffer from its skeletal or renal complications. In contrast, primary hyperparathyroidism presents its traditional manifestations in the East and in some regions of the Southern Hemisphere. In these regions, it is associated with more symptoms, large parathyroid tumors, and a higher incidence of parathyroid cancers. Many of the similarities between traditional primary hyperparathyroidism of the West and contemporary primary hyperparathyroidism of the East are explained by the differences in prevailing surveillance patterns and vitamin D and calcium nutrition of the populations. The higher prevalence of parathyroid cancers may be a reflection of an exaggerated growth behavior of abnormal parathyroid tissue partly influenced by vitamin D and calcium nutritional status of the individual. It is reasonable to infer that more severe bone disease—such as osteitis fibrosa cystica, brown tumors, and pathologic fractures are likely only when excess parathyroid hormone secretion is accompanied by profound and prolonged vitamin D and calcium malnutrition. Continued observations and comparisons of patients with primary hyperparathyroidism from different parts of the world are likely to provide even greater insights into this ever-changing disease.

Published
2001

3. Contributors

Author

Joseph M. Alexander, Andrew Arnold, Jane E. Aubin, Cristina Bandeira, Francisco Bandeira, John P. Bilezikian, F. Richard Bringhurst, Arthur E. Broadus, Edward M. Brown, Ernesto Canalis, Gustav Celdas, Naibedya Chattopadhyay, Michael Chorev, Thomas L. Clemens, Jack W. Coburn, Arthur Conigrave, L.J. Deftos, David W. Dempster, Gerard M. Doherty, John L. Doppman, Robert W. Downs, Marc K. Drezner, Murray J. Favus, Lorraine A. Fitzpatrick, Ghada El-Hajj Fuleihan, Robert F. Gagel, Paul G. Gauger, Emily L. Germain-Lee, David Goltzman, Esther A. González, Andrew Grey, Luiz Griz, David Heath, Hunter Heath, Johan N.M. Heersche, Janet M. Hock, Karl Insogna, Suzanne M. Jan de Beur, Harald Jüppner, Andrew C. Karaplis, Sundeep Khosla, Michael Kleerekoper, Vanessa A. Klugman, Richard Kremer, Henry M. Kronenberg, Kaechoong Lee, Michael A. Levine, Virginia A. LiVolsi, Sverker Ljunghall, Ewa Lundgren, Geisa Macedo, Lawrence Mallette, Robert Marcus, John T. Martin, Kevin J. Martin, Stephen J. Marx, Urszula Masiukiewicz, L.J. Melton, Xunwu Meng, Saroj K. Mishra, Ambrish Mithal, Maryann Mitnick, Jean E. Mulder, Gregory R. Mundy, Inaam A. Nakchbandi, M. T. Audrey Nguyen, Robert A. Nissenson, Babatunde Oyajobi, Charles Y.C. Pak, A. Michael Parfitt, May Parisien, William M. Philbrick, John T. Potts, Lawrence G. Raisz, D. Sudhaker Rao, Jonas Rastad, B.L. Riggs, Michael Rosenblatt, Robert K. Rude, Isidro B. Salusky, Markus J. Seibel, Gino V. Segre, Elizabeth Shane, Yifan Shi, Caroline Silve, Shonni J. Silverberg, Eduardo Slatopolsky, Andrew F. Stewart, John L. Stock, Gordon J. Strewler, R.V. Thakker, Norman W. Thompson, Robert Udelsman, Lee S. Weinstein, Samuel A. Wells, Michael P. Whyte, and John J. Wysolmerski

Published
2001

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