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1. Section Editors

Author

Michelangelo Bortolin, Srihari Cattamanchi, Edward W. Cetaruk, Alexander Hart, Attila J. Hertelendy, PhD, Fadi S. Issa, Irving 'Jake' Jacoby, J. Lee Jenkins, Shane Kappler, James M. Madsen, Selwyn E. Mahon, Ian Norton, Luca Ragazzoni, Michael Rubin, Leon D. Sanchez, Charles Stewart, and Eric S. Weinstein

Published
2024
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2. Contributors

Author

Axel Adams, Clara Affun-Adegbulu, Rakan S. Al-Rasheed, Yasser A. Alaska, Abdulaziz D. Aldawas, Saleh Ali Alesa, George A. Alexander, Abdullah Ahmed Alhadhira, Fahad Saleha Alhajjaj, Hazem H. Alhazmi, Zainab Abdullah Alhussaini, Nawfal Aljerian, Majed Aljohani, Khaldoon H. AlKhaldi, Eyad Alkhattabi, Bryant Allen, Austin Almand, Moza M. Alnoaimi, Mohammad Alotaibi, Evan Avraham Alpert, Yasir A. Alrusayni, Mai Alshammari, Loui K. Alsulimani, Siraj Amanullah, Arian Anderson, David Arastehmanesh, Ali Ardalan, Killiam A. Argote-Araméndiz, Andrew W. Artenstein, Olivia E. Bailey, Russell Baker, Satchit Balsari, Gregory T. Banner, Fermin Barrueto M, Susan A. Bartels, Joshua J. Baugh, Frederic Berg, Vijai Bhola, William Binder, Michelangelo Bortolin, Vincent Bounes, Michael Bouton, Natasha Brown, Frederick M. Burkle, Jr, Lynn Barkley Burnett, Michele M. Burns, Nicholas V. Cagliuso, Sr, John Cahill, David W. Callaway, Duane C. Caneva, Srihari Cattamanchi, Alejandra Caycedo, Edward W. Cetaruk, Sneha Chacko, James C. Chang, Crystal Chiang, David T. Chiu, Gregory R. Ciottone, Jonathan Peter Ciottone, Melissa A. Ciottone, Robert A. Ciottone, Robert G. Ciottone, Vigen G. Ciottone, Alexander Clark, Jonathan Clark, Sean P. Conley, Joanne Cono, Arthur Cooper, Scott B. Cormier, Michael F. Court, Cord W. Cunningham, Fabrice Czarnecki, Supriya Davis, Timothy E. Davis, Gerard DeMers, Sharon Dilling, Ahmadreza Djalali, Timothy Donahoe, Joseph Donahue, Caleb Dresser, Jason Dylik, Benjamin Easter, Alexander Eastman, Laura Ebbeling, Chigozie Emetarom, Nir Eyal, Andrew J. Eyre, David J. Freeman, Franklin D. Friedman, Christie Fritz, Frederick Fung, Fiona E. Gallahue, Stephanie Chow Garbern, Mark E. Gebhart, William A. Gluckman, Craig Goolsby, Robert M. Gougelet, Fredrik Granholm, P. Gregg Greenough, Jennifer O. Grimes, Steve Grosse, Shamai A. Grossman, John T. Groves Jr, Tee L. Guidotti, George Guo, Sarah Haessler, Matthew M. Hall, John W. Hardin, Mason Harrell, Alexander Hart, MD, Melissa Harvey, Attila J. Hertelendy, PhD, Nishanth S. Hiremath, Jordan Hitchens, Christopher P. Holstege, Simon T. Horne, Steven Horng, Amer Hosin, Hans R. House, Pier Luigi Ingrassia, Fadi S. Issa, Irving 'Jake' Jacoby, Rajnish Jaiswal, Gregory Jay, J. Lee Jenkins, Josh W. Joseph, Shane Kappler, Mark E. Keim, Julie Kelman, Andrew R. Ketterer, Anas A. Khan, Ramu Kharel, Chetan U. Kharod, Thomas D. Kirsch, Anita Knopov, Max Kravitz, J. Austin Lee, Jay Lemery, Evan L. Leventhal, Jesse Loughlin, Stephanie Ludy, Brian J. Maguire, Selwyn E. Mahon, Paul M. Maniscalco, Philip Manners, Leonard Jay Marcus, Colton Margus, Taha M. Masri, Jeff Matthews, Sean D. McKay, Zeke J. McKinney, Robert K. McLellan, Eric J. McNulty, Faroukh Mehkri, Mandana Mehta, Rebecca A. Mendelsohn, Ofer Merin, Andrew Milsten, Dale M. Molé, Michael Sean Molloy, Ilaria Morelli, Jerry L. Mothershead, John Mulhern, Nicole F. Mullendore, Nicholas J. Musisca, Sonya Naganathan, Larry A. Nathanson, Erica L. Nelson, Lewis S. Nelson, Bradford A. Newbury, Kimberly Newbury, Ansley O’Neill, Robert Obernier, Jacopo M. Olagnero, Leonie Oostrom-Shah, Catherine Y. Ordun, Scott Parazynski, Andrew J. Park, Robert Partridge, Jeffrey S, James P. Phillips, Emily Pinter, David P. Polatty IV, Patrick Popieluszko, William Porcaro, Lawrence Proano, Peter B. Pruitt, Moiz Qureshi, Luca Ragazzoni, Murtaza Rashid, Paul Patrick Rega, Michael J. Reilly, Marc C. Restuccia, James J. Rifino, Paul M. Robben, Joy L. Rosenblatt, Kevin M. Ryan, Heather Rybasack-Smith, Richard James Salway, Daniel Samo, Leon D. Sanchez, Shawn M. Sanford, Ritu R. Sarin, Deesha Sarma, Jesse Schacht, Valarie Schwind, Geoffrey L. Shapiro, Joshua Sheehan, Brian Shreve, Grigor Simonyan, Devin M. Smith, E. Reed Smith, MD, Jack E. Smith, MA, Montray Smith, Peter B. Smulowitz, Angela M. Snyder, Joshua J. Solano, Bryan A. Stenson, Charles Stewart, M. Kathleen Stewart, Patrick Sullivan, Jared S. Supple, Derrick Tin, Jonathan Harris Valente, Kathryn M. Vear, P.R. Vidyalakshmi, Faith Vilas, Gary M. Vilke, Janna H. Villano, Amalia Voskanyan, C. James Watson, Nancy Weber, Scott G. Weiner, Brielle Weinstein, Eric S. Weinstein, Jordan R. Werner, Roy Karl Werner, MD, James D. Whitledge, Sage W. Wiener, Lauren Wiesner, Kenneth A. Williams, Robyn Wing, Richard E. Wolfe, Wendy Hin-Wing Wong, Robert Woolard, Prasit Wuthisuthimethawee, and Nadine A. Youssef

Published
2024
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6. Logistics and maintenance research activities for DONES facility

Author

F. Arranz, T. Lehmann, F. Rauscher, G. Fischer, S. Koehler, J. Garrido, M. Rouret, and D. Sanchez-Herranz

Subjects
Nuclear Energy and Engineering, Maintenance, Mechanical Engineering, Intralogistics simulation, General Materials Science, DONES, Logistics, ddc:620, Engineering & allied operations, Civil and Structural Engineering
Abstract

DONES is planned to operate on a continuous basis with only two beam stop periods per year for maintenance. The planned operational availability is 70 %, which calls for a carefully analyzed preventive maintenance. The purpose of the research is to propose a realistic and comprehensive logistics and maintenance plan. All the maintenance activities are included in a Maintenance Matrix based on the Plant Breakdown Structure of the project. This is the basis for the creation of a maintenance plan that will lead to a Work Schedule. Special mention within this matrix will be given to those Maintenance operations that must be included in order to comply with regulation. The need of replacement of components impose some requirements on the dimensions of architec tural features of the main building such as doors, airlocks, corridors and shipping bays. To enable these re placements, the flow of materials has been developed and analyzed by an intralogistics simulation with AnyLogic. The results of this simulation lead to modifications on either the building or the components such that the replacements are feasible. The periodic replacement of an activated component has been analyzed using FMEA methodology resulting in proposals for the plant equipment designers as well as the remote handling equipment designers. Virtual reality simulations are used for a staged approach to the maintenance operation. The simulation of the HEBT scraper helped to define in detail each step or the maintenance operation. This tool has proven to be very useful to prompt changes in both the plant equipment design and the remote handling equipment. Also, the procedure of the operation itself can be refined and optimized. The conclusion of the research activities is the contribution to the definition of the building, plant equipment and achievement of the target availability., European Commission 101052200

Published
2023

7. Contributors

Author

Pablo Abuin, Marcelo Actis, Alma Y. Alanis, Anet J.N. Anelone, Mauricio Castaño-Arcila, Bruno A. Escalante, Antonio Ferramosca, Carlos Enrique Gálvez-de León, Karen Garza Cuellar, Alejandro H. González, M. Hernandez-Gonzalez, Gustavo Hernandez-Mejia, Esteban A. Hernandez-Vargas, Peter Kim, Flora Tshinanu Musuamba, Mara Pérez, Amelia Ríos, Pablo S. Rivadeneira, Jesús Rodríguez-González, Oscar D. Sanchez, Sarah K. Spurgeon, Pauline Thémans, Eduardo Ruiz Velázquez, María F. Villa-Tamayo, and Joseph J. Winkin

Published
2022
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9. A proximity labeling protocol to probe proximity interactions in C. elegans

Author

Ariana D. Sanchez and Jessica L. Feldman

Subjects
Microscopy, Q1-390, Model Organisms, Science (General), General Immunology and Microbiology, Molecular/Chemical Probes, General Neuroscience, Developmental biology, Cell Biology, Molecular Biology, General Biochemistry, Genetics and Molecular Biology
Abstract

Summary: Enzyme-catalyzed proximity labeling (PL) has emerged as a critical approach for identifying protein-protein proximity interactions in cells; however, PL techniques were not historically practical in living multicellular organisms due to technical limitations. Here, we present a protocol for applying PL to living C. elegans using the biotin ligase mutant enzyme TurboID. We demonstrated PL in a tissue-specific and region-specific manner by focusing on non-centrosomal MTOCs (ncMTOCs) of intestinal cells. This protocol is useful for targeted in vivo protein network profiling.For complete details on the use and execution of this protocol, please refer to Sanchez et al. (2021).

Published
2021

10. Contributor contact details

Author

Huang, Qingrong, primary, Augustin, M.A., additional, Oliver, C.M., additional, Riviere, Jim E., additional, Dudkiewicz, Agnieszka, additional, Luo, Ping, additional, Boxall, Alistair, additional, Tiede, Karen, additional, Chaudhry, Qasim, additional, Gergely, Anna, additional, Bowman, Diana, additional, Morris, V.J., additional, Li, Ji, additional, Rong, Peng, additional, Huang, Qingrong, additional, Zhong, Qixin, additional, Shah, Bhavini, additional, Thies, Curt, additional, Acosta, Edgar J., additional, McClements, David Julian, additional, Lin, Mengshi, additional, Garcia, Maria D. Sanchez, additional, Lagaron, Jose M., additional, Weiss, Jochen, additional, Kanjanapongkul, Kobsak, additional, Wongsasulak, Saowakon, additional, Yoovidhya, Tipaporn, additional, de Kruif, C.G. (Kees), additional, and van Rijn, Cees J.M., additional

Published
2012
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11. Scenarios of good Anthropocenes in southern Africa

Author

Reinette Biggs, Rika Preiser, Gina Ziervogel, Warren Nilsson, P. Odendaal, Andrew Merrie, D. Sanchez Betancourt, Ryan Blanchard, Laura Pereira, Sam Poskitt, H. Warrington-Coetzee, Maike Hamann, Nicholas King, Tanja Hichert, and 26933098 - King, Nicholas David

Subjects
0106 biological sciences, Vision, Futures, Equity (economics), 010504 meteorology & atmospheric sciences, Sociology and Political Science, General Social Sciences, General Decision Sciences, Environmental ethics, Citizen journalism, Complexity, Development, 01 natural sciences, 010601 ecology, Participatory process, Anthropocene, Paradigm shift, Sustainability, Sociology, Narratives, Business and International Management, Everyday life, Futures contract, Visions, 0105 earth and related environmental sciences
Abstract

In the rapidly changing and uncertain world of the Anthropocene, positive visions of the future could play a crucial role in catalysing deep social-ecological transformations to help guide humanity towards more sustainable and equitable futures. This paper presents the outcomes from a novel visioning process designed to elicit creative and inspirational future scenarios for southern Africa. The approach based scenario development on “seeds of good Anthropocenes”, i.e. existing initiatives or technologies that represent current, local-scale innovations for sustainability. A selection of seeds was used to create four distinct, positive visions in a participatory workshop process. Common themes that independently emerged in all four visions were i) decentralized governance and decision-making; ii) a strong emphasis on equity and empathy; iii) high levels of connectedness between people; and iv) a reinforced, respectful relationship with nature. The visions mainly differ in the extent of fusion between people and technology in everyday life, and how much nature plays a role in defining the human experience. The narratives presented here describe worlds that have undergone a more significant paradigm shift towards shared human values and stewardship of resources than is explored in most other ambient narratives for the region. These “Good Anthropocene” scenarios therefore demonstrate more radical, previously unimagined ways of thinking about sustainability futures on the African continent and beyond.

Published
2020

12. Lignocellulosic Materials for Biomedical Applications

Author

Cristina Castro, Robin Zuluaga, M. Osorio, D. Sanchez, Piedad Gañán, Tonny W. Naranjo, Isabel Cristina Ortiz, Orlando J. Rojas, and A. Cañas

Subjects
chemistry.chemical_compound, chemistry, Tissue engineering, Biocompatibility, Drug delivery, Lignin, Hemicellulose, Nanotechnology, Cellulose, Cell labeling, Nanocellulose
Abstract

Recent advances in materials science and nanotechnology together with ecological awareness have increased interest in the development of green products. The biomedical industry is not an exemption and lignocellulosic biomaterials have become of great interest, given their inherent biocompatibility. Concurrently, they are part of bio-systems and offer great versatility as far as properties and availability. In their native state, lignocellulosic biomaterials, e.g., in wood, typically comprise cellulose (35–50 wt.%), hemicellulose (20–35 wt.%), and lignin (10–25 wt.%). For biomedical applications these three components are promising green resources. Since ancient times cellulose have been used in gauzes for treatment of wounds; presently, it offers a wide range of possibilities that have been opened by nanotechnologies. Cellulose assembly is similar to that of collagen, the major component of extracellular matrices, and its applications are diverse, ranging from three-dimensional scaffolds for tissue engineering, implants for cell regeneration, or cell labeling. Likewise, hemicelluloses bring their own potential, for example, in drug delivery systems where they excel in performance. Likewise, due to its chemical heterogeneity, lignin is an excellent source of bioactive components, displays antioxidant activity, and can be used in pathogen treatment. This chapter discusses some relevant biomedical applications of lignocellulosic biomaterials. It will also highlight applications of bacterial nanocellulose, which has the same chemical structure than vegetable cellulose, but brings some additional properties, especially those critical in biomedical fields. In the medium to long term, lignocellulosic biomaterials will play an important role for improving life quality, for helping in developing tissues and organs, and for accelerating healing processes.

Published
2020
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13. List of contributors

Author

Izlia J. Arroyo-Maya, José Campos-Terán, A. Cañas, C. Castro, Brian D. Condon, Oriol Cusola, J. Vincent Edwards, Zhiqiang Fang, Ilari Filpponen, Krystal R. Fontenot, P. Gañán, Diego Gómez-Maldonado, Amy S. Gong, David Haldane, Maribel Hernández-Guerrero, Liangbing Hu, Heli Kangas, Ilkka Kilpeläinen, Jung-Hwan Kim, Alistair W.T. King, Hirotaka Koga, Per A. Larsson, Donggue Lee, Sang-Young Lee, Falk Liebner, Markus Linder, Roxana López-Simeon, Pezhman Mohammadi, Sunghyun Nam, T. Naranjo, Masaya Nogi, Tiina Nypelö, I. Ortiz, M. Osorio, Maria Soledad Peresin, Nicole Pircher, Marja Pitkänen, Sven Plappert, O.J. Rojas, D. Sanchez, Justin O. Zoppe, and R. Zuluaga

Published
2020
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14. Contributors

Author

S. Aland, D. Anne-Archard, R. Chatelin, R.J. Clarke, J. Collis, F. de Monte, A. Didier, C. Gross Jones, A. Haji-Sheikh, M.-J. Huang, L. Irons, D. Jefferies, G.E. Kapellos, S. Khalid, A.V. Kuznetsov, I.A. Kuznetsov, M. Lin, H. Liu, S. Liu, T.J. Lu, M. Marino, S. Marze, A. Mikhailov, S. Miller, K. Mitra, M. Murris-Espin, R.D. O'Dea, P. Poncet, G. Pontrelli, D. Sanchez, C.A. Simmons, M. Thiriet, G. Vairo, J.F. Wong, P. Wriggers, F. Xu, and E.W.K. Young

Published
2017
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16. Aircraft Hijacking

Author

Leon D. Sanchez, Kurt R. Horst, and Laura G. Ebbeling

Subjects
business.industry, Medicine, business
Published
2016
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17. Gunshot Attack

Author

Leon D. Sanchez and Matthew Babineau

Subjects
business.industry, Forensic engineering, Medicine, Mass Casualty, business
Published
2016
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18. Contributors

Author

Yasser A. Alaska, Abdulaziz D. Aldawas, Saleh Ali Alesa, George A. Alexander, Hazem H. Alhazmi, Nawfal Aljerian, Majed AlJohani, Khaldoon H. AlKhaldi, Bryant Allen, Bader S. Alotaibi, Mohammad Alotaibi, Evan Avraham Alpert, Rakan S. Al-Rasheed, Mai Alshammari, Asaad Alsufyani, Siraj Amanullah, Ali Ardalan, Andrew W. Artenstein, Miriam Aschkenasy, Matthew R. Babineau, Kavita Babu, Olivia E. Bailey, Gregory T. Banner, Fermin Barrueto, Susan A. Bartels, Bruce M. Becker, Paul D. Biddinger, Eike Blohm, Susan R. Blumenthal, Stephen W. Borron, Michelangelo Bortolin, Michael Bouton, Peter Brewster, Churton Budd, James M. Burke, Frederick M. Burkle, Lynne Barkley Burnett, Nicholas V. Cagliuso, John D. Cahill, David W. Callaway, Duane C. Caneva, David M. Canther, Srihari Cattamanchi, Edward W. Cetaruk, James C. Chang, Zeno L. Charles-Marcel, Anna I. Cheh, David T. Chiu, Teriggi J. Ciccone, Gregory R. Ciottone, Jonathan Peter Ciottone, Robert A. Ciottone, Diana Clapp, Raphael G. Cohen, Kathe M. Conlon, Joanne Cono, Hilarie Cranmer, Cord W. Cunningham, Steven O. Cunnion, Alison Sisitsky Curcio, Robert G. Darling, Neil B. Davids, Timothy E. Davis, Scott Deitchman, John B. Delaney, Francesco Della Corte, Gerard DeMers, William E. Dickerson, Sharon Dilling, Ahmadreza Djalali, Joseph Donahue, K. Sophia Dyer, Jason Dylik, Benjamin Easter, Laura Ebbeling, Nir Eyal, Andrew J. Eyre, Saleh Fares, Katherine Farmer, Denis J. FitzGerald, Elizabeth Foley, Kerry Fosher, David Freeman, Robert L. Freitas, Franklin D. Friedman, Frederick Fung, Fiona E. Gallahue, Lucille Gans, Stephanie Chow Garbern, Mark E. Gebhart, James Geiling, Brian C. Geyer, Mary Jo Giordano, William A. Gluckman, J. Scott Goudie, Robert M. Gougelet, Benjamin Graboyes, Michael I. Greenberg, P. Gregg Greenough, Ashley L. Greiner, Mark Greve, Stephen Grosse, Shamai A. Grossman, Tee L. Guidotti, Jason B. Hack, Matthew M. Hall, John W. Hardin, John L. Hick, Nishanth S. Hiremath, Steven Horng, Geoffrey D. Horning, Kurt R. Horst, Ali A. Hosin, Amer Hosin, Hans R. House, Pier Luigi Ingrassia, Patrick M. Jackson, Irving 'Jake' Jacoby, Rajnish Jaiswal, Adam J. Janicki, Gregory Jay, Miriam John, Shawn E. Johnson, James R. Johnston, Jerrilyn Jones, Michael D. Jones, Josh W. Joseph, Patrice Joseph, Alexis Kearney, Donald Keen, Mark E. Keim, Elizabeth Kenez, Katharyn E. Kennedy, Anas A. Khan, Chetan U. Kharod, Sylvia H. Kim, Kevin King, Mark A. Kirk, Leo Kobayashi, Lara K. Kulchycki, Rick G. Kulkarni, Joseph Lauro, Benjamin J. Lawner, David V. Le, Debra Lee, Terrance T. Lee, Jay Lemery, Jeanette A. Linder, Lawrence S. Linder, Michael A. Loesch, Heather Long, Kate Longley-Wood, Michael D. Mack, John M. Mackay, Laura Macnow, James M. Madsen, Brian J. Maguire, Patrick J. Maher, Selwyn E. Mahon, John D. Malone, Marco Mangini, Paul M. Maniscalco, David Marcozzi, Pietro D. Marghella, Jeff Matthews, Peter McCahill, Sean D. McKay, C. Crawford Mecham, Mandana Mehta, Patricia L. Meinhardt, Laura Diane Melville, Angela M. Mills, Andrew M. Milsten, Clifford S. Mitchell, Dale M. Molé, Michael Sean Molloy, John Moloney, Ilaria Morelli, Jerry L. Mothershead, John Mulhern, Nicole F. Mullendore, Larry A. Nathanson, Amelia Marie Nelson, Erica L. Nelson, Lewis S. Nelson, Carey Nichols, Mariann Nocera, Erin E. Noste, Catherine Y. Ordun, Peter D. Panagos, Robert Partridge, Jeffrey S. Paul, Catherine Pettit, James Pfaff, James P. Phillips, Jason Pickett, William Porcaro, Thérèse M. Postel, Charles N. Pozner, P.R. Vidyalakshmi, Lawrence Proano, Peter B. Pruitt, Jeffrey S. Rabrich, Jeffrey D. Race, Luca Ragazzoni, Najma Rahman-Kahn, Kristin Allyce Reed, Wende R. Reenstra, Paul P. Rega, Michael J. Reilly, Andrew T. Reisner, Marc C. Restuccia, James J. Rifino, James Michael Riley, Paul M. Robben, Kevin M. Ryan, Heather Rybasack-Smith, Leon D. Sanchez, Ritu R. Sarin, Debra D. Schnelle, Valarie Schwind, Malcolm Seheult, Kinjal N. Sethuraman, Geoffrey L. Shapiro, Marc J. Shapiro, Sam Shen, Suzanne M. Shepherd, William H. Shoff, Craig Sisson, Alexander P. Skog, Jonathan E. Slutzman, Devin M. Smith, E. Reed Smith, Jack E. Smith, Peter B. Smulowitz, Angela M. Snyder, Joshua J. Solano, John Sorenson, Kimberly A. Stanford, Charles Stewart, M. Kathleen Stewart, Carol Sulis, Robert J. Tashjian, Elizabeth S. Temin, Andrea G. Tenner, Craig D. Thorne, Jason A. Tracy, Milana Trounce, Jonathan Harris Valente, Alice Venier, Faith Vilas, Gary M. Vilke, Janna H. Villano, Barbara Vogt, Amalia Voskanyan, Scott G. Weiner, Brielle Weinstein, Eric S. Weinstein, Scott D. Weir, Roy Karl Werner, Sage W. Wiener, Kenneth A. Williams, Robyn Wing, Wendy Hin-Wing Wong, Richard E. Wolfe, Stephen P. Wood, Robert H. Woolard, Prasit Wuthisuthimethawee, Kevin Yeskey, Sami A. Yousif, Nadine A. Youssef, and Brian J. Yun

Published
2016
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19. Contributors

Author

M.M. Apo, T.A. Bailey, Cert Zoo Med, B. Barca Ruibal, J.V. Baskar, H. Beaufrère, J.E. Cooper, M.E. Cooper, P. Coutteel, M. Cowan, L. Crosta, F.J. Dein, A.B. del Rio, R. Doneley, N.A. Forbes, B. Gartrell, S. Hammer, J.M. Hatt, M.G. Hawkins, C. Hebel, J.C. Howlett, Dip Nat Sci, J. Kinne, Cert Vet Path, Cert Trop Vet, M.E. Krautwald Junghanns, O. Krone, M.P.C. Lawton, C. Liu, M.N.F. Magno, A. Melillo, D. Monks, A. Montesinos, K. Morgan, J.L. Naldo, J. Paul-Murphy, M. Pees, M.A. Peirce, H. Pendl, J. Perlman, D. Phalen, J. Ponder, P.T. Redig, M.D. Saggese, J. Samour, D. Sanchez-Migallon Guzman, P. Sandmeier, P. Schnitzer, N.J. Schoemaker, R.K. Schuster, C. Silvanose, L. Timossi, Y.R.A. van Zeeland, P.M. Wencel, U. Wernery, M.B. Wernick, M. Ziccardi, P. Zsivanovits, P. Zucca, and P. Zwart

Published
2016
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20. Sniper Attack

Author

Leon D. Sanchez and Shawn E. Johnson

Subjects
Engineering, business.industry, business
Published
2016
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21. Contributor contact details

Author

Qingrong Huang, M.A. Augustin, C.M. Oliver, Jim E. Riviere, Agnieszka Dudkiewicz, Ping Luo, Alistair Boxall, Karen Tiede, Qasim Chaudhry, Anna Gergely, Diana Bowman, V.J. Morris, Ji Li, Peng Rong, Qixin Zhong, Bhavini Shah, Curt Thies, Edgar J. Acosta, David Julian McClements, Mengshi Lin, Maria D. Sanchez Garcia, Jose M. Lagaron, Jochen Weiss, Kobsak Kanjanapongkul, Saowakon Wongsasulak, Tipaporn Yoovidhya, C.G. (Kees) de Kruif, and Cees J.M. van Rijn

Published
2012
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22. CONTRIBUTORS

Author

GEORGE A. ALEXANDER, ANGELA C. ANDERSON, ANDREW W. ARTENSTEIN, KAVITA BABU, FERMIN BARRUETO, CARRIE BARTON, BRUCE M. BECKER, MATTHEW BERKMAN, ANDREW I. BERN, MILANA BOUKHMAN, PETER BREWSTER, CHURTON BUDD, JAMES M. BURKE, FREDERICK M. BURKLE, LYNNE BARKLEY BURNETT, NICHOLAS VINCENT CAGLIUSO, JOHN D. CAHILL, DUANE C. CANEVA, JULIE ANN P. CASANI, MARY W. CHAFFEE, HENRY C. CHANG, JAMES C. CHANG, ANNA I. CHEH, ESTHER H. CHEN, TERIGGI J. CICCONE, MARIANNE E. CINAT, GREGORY R. CIOTTONE, ROBERT A. CIOTTONE, STEVEN T. COBERY, JOANNE CONO, KELLY J. CORRIGAN, FRANCESCO Della CORTE, CHRISTO C. COURBAN, HILARIE CRANMER, STEPHEN O. CUNNION, ROBERT G. DARLING, DAVID DAVIS, TIMOTHY DAVIS, JENNIFER E. DELAPENA, CHAYAN DEY, WILLIAM E. DICKERSON, ERIC W. DICKSON, SHARON DILLING, K. SOPHIA DYER, JASON DYLIK, JONATHAN A. EDLOW, MARSHALL EIDENBERG, KHAMA D. ENNIS-HOLCOMB, DENIS J. FITZGERALD, KERRY FOSHER, ROBERT L. FREITAS, RYAN FRIEDBERG, FRANKLIN D. FRIEDMAN, FREDERICK FUNG, ROBERT D. FURBERG, WADE GAASCH, FIONA E. GALLAHUE, LUCILLE GANS, ALESSANDRo GEDDO, JAMES GEILING, PAUL GIANNONE, WILLIAM GLUCKMAN, SUSAN E. GORMAN, J. SCOTT GOUDIE, ROBERT M. GOUGELET, MARK A. GRABER, JILL A. GRANT, MICHAEL I. GREENBERG, P. GREGG GREENOUGH, SHAMAI A. GROSSMAN, TEE L. GUIDOTTI, DEBORAH GUTMAN, PINCHAS HALPERN, DAN HANFLING, RACHEL HAROZ, BONNIE H. HARTSTEIN, JOHN L. HICK, STEPHEN F. HOOD, MICHAEL HOROWITZ, KURT R. HORST, HANS R. HOUSE, CURTIS J. HUNTER, JASON IMPERATO, PIER LUIGi INGRASSIA, IRVING JACOBY, THEA JAMES, DAVID JASLOW, GREGORY D. JAY, MIRIAM JOHN, MICHAEL D. JONES, JEFFRY L. KASHUK, MARK E. KEIM, KATHARYN E. KENNEDY, PAUL D. KIM, SYLVIA H. KIM, LEO KOBAYASHI, LARA K. KULCHYCKI, RICK G. KULKARNI, CHRISTOPHer R. LANG, GREGORY L. LARKIN, THOMAS P. LeBosquet, BRUCE Y. LEE, CATHERINE Y. LEE, DAVID C. LEE, JAY LEMERY, DANIEL L. LEMKIN, JEANETTE A. LINDER, LAWRENCE S. LINDER, SHAN W. LIU, CRAIG H. LLEWELLYN, FRANCESCA LOMBARDI, HEATHER LONG, EDWARD B. LUCCI, DONALD MACMILLAN, LAURA MACNOW, JAMES M. MADSEN, BRIAN J. MAGUIRE, JOHN D. MALONE, PAUL M. MANISCALCO, DAVID MARCOZZI, PIETRO D. MARGHELLA, JAMES F. MARTIN, JAMES MCKINNELL, MICHELLE MCMAHON-DOWNER, C. CRAWFOrd MECHEM, SUMERU MEHTA, PATRICIA L. MEINHARDT, LAURA DIAne MELVILLE, JEFFERY C. METZGER, ANGELA M. MILLS, ANDREW M. MILSTEN, CLIFFORD S. MITCHELL, ELIZABETH L. MITCHELL, DALE M. MOLÉ, LOUIS N. MOLINO, JOHN MOLONEY, SEAN MONTGOMERY, JERRY L. MOTHERSHEAD, LEWIS S. NELSON, CONSTANCE G. NICHOLS, PATRICIA A. NOLAN, DANIEL F. NOLTKAMPER, DZIWE W. NTABA, ANDREW S. NUGENT, NEILL S. OSTER, PETER D. PANAGOS, ROBERT PARTRIDGE, NICKI PESIK, JAMES PFAFF, WILLIAM PORCARO, LAWRENCE PROANO, NAJMA RAHMAN-KAHN, VITTORIO J. RAHO, PRASANTHI RAMANUJAM, WENDE R. REENSTRA, ANDREW REISNER, MARK C. RESTUCCIA, JAMES MIChael RILEY, ALBERT J. ROMANOSKY, PETER ROSEN, MARC S. ROSENTHAL, JONATHAN M. RUBIN, LEON D. SANCHEZ, DEBRA D. SCHNELLE, JEREMIAH D. SCHUUR, ERIC M. SERGIENKO, KINJAL SETHURAMAN, MARC J. SHAPIRO, SAM SHEN, SUZANNE M. SHEPHERD, WILLIAM H. SHOFF, SEAN MICHael SILER, ALISON SISITSKY, CRAIG SISSON, PETER B. SMULOWITZ, JOHN H. SORENSON, CHARLES STEWART, M. KATHLEen STEWART, KENT J. STOCK, CAROL SULIS, NICHOLAS SUTINGCO, NELSON TANG, ELIZABETH TEMIN, RICHARD A. TEMPEL, CRAIG D. THORNE, JASON A. TRACY, STEPHEN J. TRAUB, JONATHAN Harris VALENTE, VICTORIA M. VANDERKAM, CAROL L. VENABLE, FAITH VILAS, GARY M. VILKE, BARBARA Vogt SORENSON, SCOTT G. WEINER, ERIC S. WEINSTEIN, ROY KARL WERNER, SAGE W. WIENER, ABIGAIL WILLIAMS, KENNETH A. WILLIAMS, TRACY E. WIMBUSH, ROBERT H. WOOLARD, KEVIN YESKEY, SANDRA S. YOON, and PATRICK ZELLEY

Published
2006
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24. P.18. Rabdomiólisis en lactante. A propósito de un caso

Author

M.R. Cazorla, M. D. Sanchez-Redondo, M.J. Navarro, E. Zambrano, J.A. Alonso, R. Tapia, D. Arjona, and R. Borrego

Subjects
Pediatrics, Perinatology and Child Health, Pediatrics, RJ1-570
Abstract

Introduccion La rabdomiolisis es la desintegracion de las celulas del musculo esqueletico con liberacion de su contenido (mioglobina, enzimas y electrolitos) al torrente circulatorio. De curso evolutivo benigno, puede tener complicaciones graves dependiendo de la causa que la desencadene. La triada clasica: debilidad muscular, mialgias y orinas coluricas solamente se presenta en el 50 %. Se confirma por la presencia de mioglobinuria y aumento de enzimas musculares. Caso clinico Nina de 1 ano y 10 meses trasladada a UCIP por sospecha de sepsis. Clinica de 12 h de febricula, dolores musculares de predominio en extremidades inferiores y orina colurica. Tratada con cefotaxima intravenosa desde su ingreso. Antecedentes de 2 hermanos fallecidos de causa no clarificada. Exploracion fisica Regular estado general, palidez cutanea, buena perfusion periferica. Abdomen: higado a 1 cm del reborde costal derecho. ORL: faringe hiperemica con lengua tumefacta y edematosa en bordes y lesiones erosivas que sangraban discretamente. Osteoarticular: dolores musculares generalizados con induracion muscular. Dolor a la movilizacion de miembros inferiores, sin signos inflamatorios. Neurologico: tendencia al sueno, aunque normorreactiva. No signos meningeos. Pruebas complementarias Hematologia: normal. Bioquimica: aumento de CPK, GOT, GPT, CPKMB, funcion hepatica normal, lactato, amonio, lipasa y amilasa normales. Gasometria: normal. Hemocultivo: negativo. Troponina I y ecocardiografia normal. Hormonas tiroideas normales. Fenofibratos en plasma y aspirado gastrico normales. S. de orina: proteinuria, mioglobinuria, no hematuria. Biopsia muscular: cumulo patologico de glucogeno en el interior de las fibras musculares compatible con glucogenosis. Evolucion Ante rabdomiolisis se inicia tratamiento con hiperhidratacion, alcalinizacion y diureticos, y tratamiento empirico con biotina y carnitina. Disminucion de enzimas musculares a partir del tercer dia con normalizacion a los 10 dias. Posteriormente la nina ha estado asintomatica y continua revisiones periodicas. Comentarios 1. Existen multiples causas que producen rabdomiolisis: traumatica y no traumatica (inflamatoria, autoinmunitaria, infecciosa, alteraciones metabolicas y endocrinas, farmacos, toxicos y enfermedades metabolicas del musculo). En nuestro caso se sospecho una enfermedad metabolica muscular por los antecedentes familiares. 2. Entre las posibles complicaciones se encuentran las alteraciones electroliticas, el sindrome compartimental y la mas severa insuficiencia renal aguda. 3 . El tratamiento consiste en forzar diuresis hiperhidratacion y alcalinizacion para evitar la lesion renal, que es la principal causa de muerte.

Published
2007

25. Emergency medicine resident productivity during the SARS-CoV-2 disease 2019 (COVID-19) pandemic

Author

Daniel L. Shaw, Bryan A. Stenson, Leon D. Sanchez, and David T. Chiu

Subjects
Internship and residency, Efficiency, Productivity, Emergency medicine, COVID-19, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) pandemic disrupted medical education in many care settings, including the Emergency Department (ED). It is unclear what effects these changes have had on resident training and clinical productivity. Objective: The purpose of this study is to determine Emergency Medicine (EM) resident productivity in the ED during the COVID-19 pandemic. Methods: This was a retrospective observational study at an academic medical center with an EM residency program. Data were collected from the electronic medical record from 7/1/2017–10/31/2021. The primary outcome was patients per hour (PPH). Postgraduate year (PGY) 1 and 2 shifts were included. Analysis included descriptive statistics (mean ​± ​standard deviation), correlation testing, and multivariate linear regression. Results: Overall, PGY1 residents saw fewer PPH than PGY2 residents (1.00 ​± ​0.12 vs 1.40 ​± ​0.13 ​PPH, p ​

Published
2024
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26. Persistent tailoring of MSC activation through genetic priming

Author

Michael A. Beauregard, Guy C. Bedford, Daniel A. Brenner, Leonardo D. Sanchez Solis, Tomoki Nishiguchi, Abhimanyu, Santiago Carrero Longlax, Barun Mahata, Omid Veiseh, Pamela L. Wenzel, Andrew R. DiNardo, Isaac B. Hilton, and Michael R. Diehl

Subjects
mesenchymal stem cells, priming, immunosuppression, interferon gamma licensing, signaling pathway engineering, immunomodulation, Genetics, QH426-470, Cytology, QH573-671
Abstract

Mesenchymal stem/stromal cells (MSCs) are an attractive platform for cell therapy due to their safety profile and unique ability to secrete broad arrays of immunomodulatory and regenerative molecules. Yet, MSCs are well known to require preconditioning or priming to boost their therapeutic efficacy. Current priming methods offer limited control over MSC activation, yield transient effects, and often induce the expression of pro-inflammatory effectors that can potentiate immunogenicity. Here, we describe a genetic priming method that can both selectively and sustainably boost MSC potency via the controlled expression of the inflammatory-stimulus-responsive transcription factor interferon response factor 1 (IRF1). MSCs engineered to hyper-express IRF1 recapitulate many core responses that are accessed by biochemical priming using the proinflammatory cytokine interferon-γ (IFN-γ). This includes the upregulation of anti-inflammatory effector molecules and the potentiation of MSC capacities to suppress T cell activation. However, we show that IRF1-mediated genetic priming is much more persistent than biochemical priming and can circumvent IFN-γ-dependent expression of immunogenic MHC class II molecules. Together, the ability to sustainably activate and selectively tailor MSC priming responses creates the possibility of programming MSC activation more comprehensively for therapeutic applications.

Published
2024
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28. Ferroptosis and kidney disease

Author

Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Julio M. Martinez-Moreno, Adrian M. Ramos, Maria D. Sanchez-Niño, Melania Guerrero-Hue, Juan A. Moreno, Alberto Ortiz, and Ana B. Sanz

Subjects
Lesión renal aguda, Enfermedad renal crónica, Inflamación, Muerte celular, Necrosis regulada, Ferroptosis, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Cell death is a finely regulated process occurring through different pathways. Regulated cell death, either through apoptosis or regulated necrosis offers the possibility of therapeutic intervention. Necroptosis and ferroptosis are among the best studied forms of regulated necrosis in the context of kidney disease. We now review the current evidence supporting a role for ferroptosis in kidney disease and the implications of this knowledge for the design of novel therapeutic strategies. Ferroptosis is defined functionally, as a cell modality characterized by peroxidation of certain lipids, constitutively suppressed by GPX4 and inhibited by iron chelators and lipophilic antioxidants. There is functional evidence of the involvement of ferroptosis in diverse forms of kidneys disease. In a well characterized nephrotoxic acute kidney injury model, ferroptosis caused an initial wave of death, triggering an inflammatory response that in turn promoted necroptotic cell death that perpetuated kidney dysfunction. This suggests that ferroptosis inhibitors may be explored as prophylactic agents in clinical nephrotoxicity or ischemia–reperfusion injury such as during kidney transplantation. Transplantation offers the unique opportunity of using anti-ferroptosis agent ex vivo, thus avoiding bioavailability and in vivo pharmacokinetics and pharmacodynamics issues. Resumen: La muerte celular es un proceso minuciosamente regulado que se desarrolla a través de diferentes vías. La muerte celular regulada, ya sea mediante apoptosis o necrosis regulada, ofrece la posibilidad de introducir una intervención terapéutica. La necroptosis y la ferroptosis se encuentran entre las formas mejor estudiadas de necrosis regulada en el contexto de la nefropatía. Revisamos los datos actuales que avalan que la ferroptosis desempeña una función en la nefropatía y las repercusiones que tiene este conocimiento en el diseño de nuevas estrategias terapéuticas. La ferroptosis se define de forma funcional como una modalidad celular caracterizada por la peroxidación de ciertos lípidos, constitutivamente suprimida por GPX4 e inhibida por quelantes férricos y antioxidantes lipofílicos. Existen datos probatorios funcionales de la implicación de la ferroptosis en diversas formas de nefropatía. En un modelo de lesión renal aguda nefrotóxica bien caracterizado, la ferroptosis provocó una ola inicial de muerte, la cual desencadenó una respuesta inflamatoria que a su vez promovió la muerte celular necroptótica que perpetuó la disfunción renal. Esto sugiere que los inhibidores de la ferroptosis pueden explorarse como agentes profilácticos en la nefrotoxicidad clínica o en la lesión por isquemia-reperfusión, como durante un trasplante de riñón. Los trasplantes ofrecen una oportunidad única para el uso de agentes inhibidores de la ferroptosis ex vivo, con lo que se evitarían los problemas de biodisponibilidad y los problemas de farmacocinética y farmacodinámica in vivo.

Published
2020
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29. A machine learning framework to predict the risk of opioid use disorder

Author

Md Mahmudul Hasan, Gary J. Young, Mehul Rakeshkumar Patel, Alicia Sasser Modestino, Leon D. Sanchez, and Md. Noor-E-Alam

Subjects
Opioid use disorder, Opioid addiction epidemic, Risk prediction, Big data analytics, Machine learning, Predictive analytics, Cybernetics, Q300-390, Electronic computers. Computer science, QA75.5-76.95
Abstract

Opioid overdose epidemic is a national public health crisis in the US. Little is known about how large-scale data analytics can be leveraged to help physicians predict whether a prescription opioid user will develop opioid use disorder. To that end, we proposed a machine learning framework for identifying potential risk factors of opioid use disorder from a large-scale healthcare claims data. These risk factors identified by the proposed framework can be used to predict which patient will be at higher risk of opioid use disorder following an opioid prescription. We utilized clinical diagnosis and prescription histories from Massachusetts commercially insured individuals who were prescribed opioids. We performed several feature selection techniques on a class imbalanced analytic sample to identify patient-level demographic and clinical features that were influential predictors of opioid use disorder. We, then compared the predictive power of four well-known machine learning algorithms: Logistic Regression, Random Forest, Decision Tree, and Gradient Boosting to predict the patients’ risk of opioid use disorder. The study results showed that the Random Forest model achieved superior predictive performance in terms of AUC and recall. Alongside the higher predictive accuracy, the random forest model identified clinical features, some of which were fairly consistent with prior clinical findings. In addition, our proposed framework is capable of extracting some other clinical features, which are predictive of opioid use disorder and indicative as the proxies of patients’ health status. We anticipate that the findings of our study will potentially help reduce in-appropriate and over prescription of opioids.

Published
2021
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30. A prospective examination of sex differences in posttraumatic autonomic functioning

Author

Antonia V. Seligowski, Elizabeth R. Steuber, Rebecca Hinrichs, Mariam H. Reda, Charis N. Wiltshire, Cassandra P. Wanna, Sterling J. Winters, Karlye A. Phillips, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Guia Guffanti, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Jr., Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Vishnu P. Murty, Meghan E. McGrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Anna M. Chang, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Beatriz Luna, Steven E. Harte, James M. Elliott, Karestan C. Koenen, Ronald C. Kessler, Samuel A. McLean, Kerry J. Ressler, and Tanja Jovanovic

Subjects
Trauma, PTSD, Autonomic, Sex, Cardiovascular, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495
Abstract

Background: Cross-sectional studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit deficits in autonomic functioning. While PTSD rates are twice as high in women compared to men, sex differences in autonomic functioning are relatively unknown among trauma-exposed populations. The current study used a prospective design to examine sex differences in posttraumatic autonomic functioning. Methods: 192 participants were recruited from emergency departments following trauma exposure (Mean age = 35.88, 68.2% female). Skin conductance was measured in the emergency department; fear conditioning was completed two weeks later and included measures of blood pressure (BP), heart rate (HR), and high frequency heart rate variability (HF-HRV). PTSD symptoms were assessed 8 weeks after trauma. Results: 2-week systolic BP was significantly higher in men, while 2-week HR was significantly higher in women, and a sex by PTSD interaction suggested that women who developed PTSD demonstrated the highest HR levels. Two-week HF-HRV was significantly lower in women, and a sex by PTSD interaction suggested that women with PTSD demonstrated the lowest HF-HRV levels. Skin conductance response in the emergency department was associated with 2-week HR and HF-HRV only among women who developed PTSD. Conclusions: Our results indicate that there are notable sex differences in autonomic functioning among trauma-exposed individuals. Differences in sympathetic biomarkers (BP and HR) may have implications for cardiovascular disease risk given that sympathetic arousal is a mechanism implicated in this risk among PTSD populations. Future research examining differential pathways between PTSD and cardiovascular risk among men versus women is warranted.

Published
2021
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31. Observation of the Λb0→Λc+K+K−π− decay

Author

R. Aaij, C. Abellán Beteta, T. Ackernley, B. Adeva, M. Adinolfi, H. Afsharnia, C.A. Aidala, S. Aiola, Z. Ajaltouni, S. Akar, J. Albrecht, F. Alessio, M. Alexander, A. Alfonso Albero, Z. Aliouche, G. Alkhazov, P. Alvarez Cartelle, S. Amato, Y. Amhis, L. An, L. Anderlini, A. Andreianov, M. Andreotti, F. Archilli, A. Artamonov, M. Artuso, K. Arzymatov, E. Aslanides, M. Atzeni, B. Audurier, S. Bachmann, M. Bachmayer, J.J. Back, S. Baker, P. Baladron Rodriguez, V. Balagura, W. Baldini, J. Baptista Leite, R.J. Barlow, S. Barsuk, W. Barter, M. Bartolini, F. Baryshnikov, J.M. Basels, G. Bassi, B. Batsukh, A. Battig, A. Bay, M. Becker, F. Bedeschi, I. Bediaga, A. Beiter, V. Belavin, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, D. Berninghoff, H.C. Bernstein, C. Bertella, E. Bertholet, A. Bertolin, C. Betancourt, F. Betti, M.O. Bettler, Ia. Bezshyiko, S. Bhasin, J. Bhom, L. Bian, M.S. Bieker, S. Bifani, P. Billoir, M. Birch, F.C.R. Bishop, A. Bizzeti, M. Bjørn, M.P. Blago, T. Blake, F. Blanc, S. Blusk, D. Bobulska, J.A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Boldyrev, A. Bondar, N. Bondar, S. Borghi, M. Borisyak, M. Borsato, J.T. Borsuk, S.A. Bouchiba, T.J.V. Bowcock, A. Boyer, C. Bozzi, M.J. Bradley, S. Braun, A. Brea Rodriguez, M. Brodski, J. Brodzicka, A. Brossa Gonzalo, D. Brundu, A. Buonaura, C. Burr, A. Bursche, A. Butkevich, J.S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, L. Calefice, L. Calero Diaz, S. Cali, R. Calladine, M. Calvi, M. Calvo Gomez, P. Camargo Magalhaes, A. Camboni, P. Campana, D.H. Campora Perez, A.F. Campoverde Quezada, S. Capelli, L. Capriotti, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, I. Carli, P. Carniti, L. Carus, K. Carvalho Akiba, A. Casais Vidal, G. Casse, M. Cattaneo, G. Cavallero, S. Celani, J. Cerasoli, A.J. Chadwick, M.G. Chapman, M. Charles, Ph. Charpentier, G. Chatzikonstantinidis, C.A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, A. Chernov, S.-G. Chitic, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, M.F. Cicala, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, J.L. Cobbledick, V. Coco, J.A.B. Coelho, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, L. Congedo, A. Contu, N. Cooke, G. Coombs, G. Corti, C.M. Costa Sobral, B. Couturier, D.C. Craik, J. Crkovská, M. Cruz Torres, R. Currie, C.L. Da Silva, E. Dall'Occo, J. Dalseno, C. D'Ambrosio, A. Danilina, P. d'Argent, A. Davis, O. De Aguiar Francisco, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, M. De Serio, D. De Simone, P. De Simone, J.A. de Vries, C.T. Dean, W. Dean, D. Decamp, L. Del Buono, B. Delaney, H.-P. Dembinski, A. Dendek, V. Denysenko, D. Derkach, O. Deschamps, F. Desse, F. Dettori, B. Dey, P. Di Nezza, S. Didenko, L. Dieste Maronas, H. Dijkstra, V. Dobishuk, A.M. Donohoe, F. Dordei, A.C. dos Reis, L. Douglas, A. Dovbnya, A.G. Downes, K. Dreimanis, M.W. Dudek, L. Dufour, V. Duk, P. Durante, J.M. Durham, D. Dutta, M. Dziewiecki, A. Dziurda, A. Dzyuba, S. Easo, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, S. Ek-In, L. Eklund, S. Ely, A. Ene, E. Epple, S. Escher, J. Eschle, S. Esen, T. Evans, A. Falabella, J. Fan, Y. Fan, B. Fang, N. Farley, S. Farry, D. Fazzini, P. Fedin, M. Féo, P. Fernandez Declara, A. Fernandez Prieto, J.M. Fernandez-tenllado Arribas, F. Ferrari, L. Ferreira Lopes, F. Ferreira Rodrigues, S. Ferreres Sole, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R.A. Fini, M. Fiorini, M. Firlej, K.M. Fischer, C. Fitzpatrick, T. Fiutowski, F. Fleuret, M. Fontana, F. Fontanelli, R. Forty, V. Franco Lima, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D.A. Friday, J. Fu, Q. Fuehring, W. Funk, E. Gabriel, T. Gaintseva, A. Gallas Torreira, D. Galli, S. Gambetta, Y. Gan, M. Gandelman, P. Gandini, Y. Gao, M. Garau, L.M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, B. Garcia Plana, F.A. Garcia Rosales, L. Garrido, D. Gascon, C. Gaspar, R.E. Geertsema, D. Gerick, L.L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, D. Gerstel, Ph. Ghez, V. Gibson, M. Giovannetti, A. Gioventù, P. Gironella Gironell, L. Giubega, C. Giugliano, K. Gizdov, E.L. Gkougkousis, V.V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, P. Gorbounov, I.V. Gorelov, C. Gotti, E. Govorkova, J.P. Grabowski, R. Graciani Diaz, T. Grammatico, L.A. Granado Cardoso, E. Graugés, E. Graverini, G. Graziani, A. Grecu, L.M. Greeven, P. Griffith, L. Grillo, S. Gromov, L. Gruber, B.R. Gruberg Cazon, C. Gu, M. Guarise, P.A. Günther, E. Gushchin, A. Guth, Y. Guz, T. Gys, T. Hadavizadeh, G. Haefeli, C. Haen, J. Haimberger, S.C. Haines, T. Halewood-leagas, P.M. Hamilton, Q. Han, X. Han, T.H. Hancock, S. Hansmann-Menzemer, N. Harnew, T. Harrison, C. Hasse, M. Hatch, J. He, M. Hecker, K. Heijhoff, K. Heinicke, A.M. Hennequin, K. Hennessy, L. Henry, J. Heuel, A. Hicheur, D. Hill, M. Hilton, S.E. Hollitt, P.H. Hopchev, J. Hu, W. Hu, W. Huang, X. Huang, W. Hulsbergen, R.J. Hunter, M. Hushchyn, D. Hutchcroft, D. Hynds, P. Ibis, M. Idzik, D. Ilin, P. Ilten, A. Inglessi, A. Ishteev, K. Ivshin, R. Jacobsson, S. Jakobsen, E. Jans, B.K. Jashal, A. Jawahery, V. Jevtic, M. Jezabek, F. Jiang, M. John, D. Johnson, C.R. Jones, T.P. Jones, B. Jost, N. Jurik, S. Kandybei, Y. Kang, M. Karacson, M. Karpov, N. Kazeev, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, K.E. Kim, T. Kirn, V.S. Kirsebom, O. Kitouni, S. Klaver, K. Klimaszewski, S. Koliiev, A. Kondybayeva, A. Konoplyannikov, P. Kopciewicz, R. Kopecna, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, P. Kravchenko, L. Kravchuk, R.D. Krawczyk, M. Kreps, F. Kress, S. Kretzschmar, P. Krokovny, W. Krupa, W. Krzemien, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, H.S. Kuindersma, G.J. Kunde, T. Kvaratskheliya, D. Lacarrere, G. Lafferty, A. Lai, A. Lampis, D. Lancierini, J.J. Lane, R. Lane, G. Lanfranchi, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, R. Le Gac, S.H. Lee, R. Lefèvre, A. Leflat, S. Legotin, O. Leroy, T. Lesiak, B. Leverington, H. Li, L. Li, P. Li, X. Li, Y. Li, Z. Li, X. Liang, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, G. Liu, H. Liu, S. Liu, X. Liu, A. Loi, J. Lomba Castro, I. Longstaff, J.H. Lopes, G. Loustau, G.H. Lovell, Y. Lu, D. Lucchesi, S. Luchuk, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, O. Lupton, A. Lusiani, X. Lyu, L. Ma, S. Maccolini, F. Machefert, F. Maciuc, V. Macko, P. Mackowiak, S. Maddrell-Mander, O. Madejczyk, L.R. Madhan Mohan, O. Maev, A. Maevskiy, D. Maisuzenko, M.W. Majewski, J.J. Malczewski, S. Malde, B. Malecki, A. Malinin, T. Maltsev, H. Malygina, G. Manca, G. Mancinelli, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. Maratas, J.F. Marchand, U. Marconi, S. Mariani, C. Marin Benito, M. Marinangeli, P. Marino, J. Marks, P.J. Marshall, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, M. Materok, R. Matev, A. Mathad, Z. Mathe, V. Matiunin, C. Matteuzzi, K.R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, M. Mazurek, M. McCann, L. Mcconnell, T.H. Mcgrath, A. McNab, R. McNulty, J.V. Mead, B. Meadows, C. Meaux, G. Meier, N. Meinert, D. Melnychuk, S. Meloni, M. Merk, A. Merli, L. Meyer Garcia, M. Mikhasenko, D.A. Milanes, E. Millard, M. Milovanovic, M.-N. Minard, L. Minzoni, S.E. Mitchell, B. Mitreska, D.S. Mitzel, A. Mödden, R.A. Mohammed, R.D. Moise, T. Mombächer, I.A. Monroy, S. Monteil, M. Morandin, G. Morello, M.J. Morello, J. Moron, A.B. Morris, A.G. Morris, R. Mountain, H. Mu, F. Muheim, M. Mukherjee, M. Mulder, D. Müller, K. Müller, C.H. Murphy, D. Murray, P. Muzzetto, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, I. Neri, N. Neri, S. Neubert, N. Neufeld, R. Newcombe, T.D. Nguyen, C. Nguyen-Mau, E.M. Niel, S. Nieswand, N. Nikitin, N.S. Nolte, C. Nunez, A. Oblakowska-Mucha, V. Obraztsov, D.P. O'Hanlon, R. Oldeman, M.E. Olivares, C.J.G. Onderwater, A. Ossowska, J.M. Otalora Goicochea, T. Ovsiannikova, P. Owen, A. Oyanguren, B. Pagare, P.R. Pais, T. Pajero, A. Palano, M. Palutan, Y. Pan, G. Panshin, A. Papanestis, M. Pappagallo, L.L. Pappalardo, C. Pappenheimer, W. Parker, C. Parkes, C.J. Parkinson, B. Passalacqua, G. Passaleva, A. Pastore, M. Patel, C. Patrignani, C.J. Pawley, A. Pearce, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, D. Pereima, P. Perret, K. Petridis, A. Petrolini, A. Petrov, S. Petrucci, M. Petruzzo, T.T.H. Pham, A. Philippov, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, M. Pili, D. Pinci, J. Pinzino, F. Pisani, A. Piucci, P.K. Resmi, V. Placinta, S. Playfer, J. Plews, M. Plo Casasus, F. Polci, M. Poli Lener, M. Poliakova, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, G.J. Pomery, S. Ponce, A. Popov, D. Popov, S. Popov, S. Poslavskii, K. Prasanth, L. Promberger, C. Prouve, V. Pugatch, A. Puig Navarro, H. Pullen, G. Punzi, W. Qian, J. Qin, R. Quagliani, B. Quintana, N.V. Raab, R.I. Rabadan Trejo, B. Rachwal, J.H. Rademacker, M. Rama, M. Ramos Pernas, M.S. Rangel, F. Ratnikov, G. Raven, M. Reboud, F. Redi, F. Reiss, C. Remon Alepuz, Z. Ren, V. Renaudin, R. Ribatti, S. Ricciardi, K. Rinnert, P. Robbe, A. Robert, G. Robertson, A.B. Rodrigues, E. Rodrigues, J.A. Rodriguez Lopez, A. Rollings, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, J.D. Roth, M. Rotondo, M.S. Rudolph, T. Ruf, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J.J. Saborido Silva, N. Sagidova, N. Sahoo, B. Saitta, D. Sanchez Gonzalo, C. Sanchez Gras, R. Santacesaria, C. Santamarina Rios, M. Santimaria, E. Santovetti, D. Saranin, G. Sarpis, M. Sarpis, A. Sarti, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L.G. Scantlebury Smead, S. Schael, M. Schellenberg, M. Schiller, H. Schindler, M. Schmelling, T. Schmelzer, B. Schmidt, O. Schneider, A. Schopper, M. Schubiger, S. Schulte, M.H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, S. Sellam, A. Semennikov, M. Senghi Soares, A. Sergi, N. Serra, J. Serrano, L. Sestini, A. Seuthe, P. Seyfert, D.M. Shangase, M. Shapkin, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, V. Shevchenko, E.B. Shields, E. Shmanin, J.D. Shupperd, B.G. Siddi, R. Silva Coutinho, G. Simi, S. Simone, I. Skiba, N. Skidmore, T. Skwarnicki, M.W. Slater, J.G. Smeaton, A. Smetkina, E. Smith, M. Smith, A. Snoch, M. Soares, L. Soares Lavra, M.D. Sokoloff, F.J.P. Soler, A. Solovev, I. Solovyev, F.L. Souza De Almeida, B. Souza De Paula, B. Spaan, E. Spadaro Norella, P. Spradlin, F. Stagni, M. Stahl, S. Stahl, P. Stefko, O. Steinkamp, S. Stemmle, O. Stenyakin, H. Stevens, S. Stone, M.E. Stramaglia, M. Straticiuc, D. Strekalina, S. Strokov, F. Suljik, J. Sun, L. Sun, Y. Sun, P. Svihra, P.N. Swallow, K. Swientek, A. Szabelski, T. Szumlak, M. Szymanski, S. Taneja, Z. Tang, T. Tekampe, F. Teubert, E. Thomas, K.A. Thomson, M.J. Tilley, V. Tisserand, S. T'Jampens, M. Tobin, S. Tolk, L. Tomassetti, D. Torres Machado, D.Y. Tou, M. Traill, M.T. Tran, E. Trifonova, C. Trippl, A. Tsaregorodtsev, G. Tuci, A. Tully, N. Tuning, A. Ukleja, D.J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, A. Vagner, V. Vagnoni, A. Valassi, G. Valenti, N. Valls Canudas, M. van Beuzekom, M. Van Dijk, H. Van Hecke, E. van Herwijnen, C.B. Van Hulse, M. van Veghel, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J.J. Velthuis, M. Veltri, A. Venkateswaran, M. Veronesi, M. Vesterinen, D. Vieira, M. Vieites Diaz, H. Viemann, X. Vilasis-Cardona, E. Vilella Figueras, P. Vincent, G. Vitali, A. Vollhardt, D. Vom Bruch, A. Vorobyev, V. Vorobyev, N. Voropaev, R. Waldi, J. Walsh, C. Wang, J. Wang, M. Wang, R. Wang, Y. Wang, Z. Wang, H.M. Wark, N.K. Watson, S.G. Weber, D. Websdale, C. Weisser, B.D.C. Westhenry, D.J. White, M. Whitehead, D. Wiedner, G. Wilkinson, M. Wilkinson, I. Williams, M. Williams, M.R.J. Williams, F.F. Wilson, W. Wislicki, M. Witek, L. Witola, G. Wormser, S.A. Wotton, H. Wu, K. Wyllie, Z. Xiang, D. Xiao, Y. Xie, H. Xing, A. Xu, J. Xu, L. Xu, M. Xu, Q. Xu, Z. Xu, D. Yang, Y. Yang, Z. Yang, Y. Yao, L.E. Yeomans, H. Yin, J. Yu, X. Yuan, O. Yushchenko, E. Zaffaroni, K.A. Zarebski, M. Zavertyaev, M. Zdybal, O. Zenaiev, M. Zeng, D. Zhang, L. Zhang, S. Zhang, Y. Zhang, A. Zhelezov, Y. Zheng, X. Zhou, Y. Zhou, X. Zhu, V. Zhukov, J.B. Zonneveld, S. Zucchelli, D. Zuliani, and G. Zunica

Subjects
Physics, QC1-999
Abstract

The Λb0→Λc+K+K−π− decay is observed for the first time using a data sample of proton-proton collisions at centre-of-mass energies of s=7 and 8TeV collected by the LHCb detector, corresponding to an integrated luminosity of 3fb−1. The ratio of branching fractions between the Λb0→Λc+K+K−π− and the Λb0→Λc+Ds− decays is measured to beB(Λb0→Λc+K+K−π−)B(Λb0→Λc+Ds−)=(9.26±0.29±0.46±0.26)×10−2, where the first uncertainty is statistical, the second systematic and the third is due to the knowledge of the Ds−→K+K−π− branching fraction. No structure on the invariant mass distribution of the Λc+K+ system is found, consistent with no open-charm pentaquark signature.

Published
2021
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32. Molecular pathways driving omeprazole nephrotoxicity

Author

Miguel Fontecha-Barriuso, Diego Martín-Sanchez, Julio M. Martinez-Moreno, Daniela Cardenas-Villacres, Susana Carrasco, Maria D. Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, and Ana B. Sanz

Subjects
Nephrotoxicity, Omeprazole, Oxidative stress, Cell death, Tubular proximal cells, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

Omeprazole, a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease, has been associated to chronic kidney disease and acute interstitial nephritis. However, whether omeprazole is toxic to renal cells is unknown. Omeprazole has a lethal effect over some cancer cells, and cell death is a key process in kidney disease. Thus, we evaluated the potential lethal effect of omeprazole over tubular cells.Omeprazole induced dose-dependent cell death in human and murine proximal tubular cell lines and in human primary proximal tubular cell cultures. Increased cell death was observed at the high concentrations used in cancer cell studies and also at lower concentrations similar to those in peptic ulcer patient serum. Cell death induced by omeprazole had features of necrosis such as annexin V/7-AAD staining, LDH release, vacuolization and irregular chromatin condensation. Weak activation of caspase-3 was observed but inhibitors of caspases (zVAD), necroptosis (Necrostatin-1) or ferroptosis (Ferrostatin-1) did not prevent omeprazole-induced death. However, omeprazole promoted a strong oxidative stress response affecting mitochondria and lysosomes and the antioxidant N-acetyl-cysteine reduced oxidative stress and cell death. By contrast, iron overload increased cell death. An adaptive increase in the antiapoptotic protein BclxL failed to protect cells. In mice, parenteral omeprazole increased tubular cell death and the expression of NGAL and HO-1, markers of renal injury and oxidative stress, respectively.In conclusion, omeprazole nephrotoxicity may be related to induction of oxidative stress and renal tubular cell death.

Published
2020
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33. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author

Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. 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Sterry, T. Wong, M. Boon, R. Bunney, R. Haria-Shah, R.T. Baron, S. Davies, T. Schatzberger, N. Hargreaves, T. Stephenson, H. Choi, R. Batson, L. Lucraft, T. Myhill, S. Estifano, D. Geatch, J. Wilkinson, R. Veale, K. Forshaw, T. Davies, K. Zaman, P. Vinson, C. Liley, M. Bandrapalli, P. McGinty, R. Wastling, P. McEleny, A. Beattie, P. Cooke, M. Wong, J. Gunasegaram, M. Pugsley, S. Ahmad, C. A'Court, J. Ayers, J. Bennett, S. Cartwright, S. Dobson, C. Dooldeniya, A. Flynn, R. Fox, J. Goram, A. Halpin, A. Hay, P. Jacobs, L. Jeffers, L. Lomax, I. Munro, R. Muvva, M. Nadaph, K. Powell, S. Randfield, D. Redpath, R. Reed, M. Rickenbach, G. Rogers, P.B. Saunders, C. Seamark, J. Shewring, P. Simmons, H. Simper, H. Stoddart, A. Sword, N. Thomas, A. Thomson, H. Gibbs, A. Blenkhorn, B. Singh, W. Van Gaal, W. Abhayaratna, R. Lehman, P. Roberts-Thomson, J. Kilian, D. Coulshed, A. Catanchin, D. Colquhoun, H. Kiat, D. Eccleston, J. French, L. Zimmett, B. Ayres, T. Phan, P. Blombery, D. Crimmins, D. O'Donnell, A. Choi, P. Astridge, M. Arstall, N. Jepson, M. Binnekamp, A. Lee, J. Rogers, G. Starmer, P. Carroll, J. Faunt, A. Aggarwala, L. Barry, C. Batta, R. Beveridge, A. Black, M. Bonner, J. Boys, E. Buckley, M. Campo, L. Carlton, A. Connelly, B. Conway, D. Cresp, H. Dimitri, S. Dixon, M. Dolman, M. Duroux, M. Eskandari, R. Eslick, A. Ferreira-Jardim, T. Fetahovic, D. Fitzpatrick, R. Geraghty, J. Gibbs, T. Grabek, M.H. Modi, K. Hayes, M.P. Hegde, L. Hesketh, B. Hoffmann, B. Jacobson, K. Johnson, C. Juergens, I. Kassam, V. Lawlor, M. Lehman, S. Lehman, D. Leung, S. Mackay, M. MacKenzie, C. McCarthy, C. McIntosh, L. McKeon, H. Morrison, C. Mussap, J.-D. Myers, V. Nagalingam, G. Oldfield, V. O'May, J. Palmer, L. Parsons, K. Patching, T. Patching, V. Paul, M. Plotz, S. Preston, H. Rashad, M. Ratcliffe, S. Raynes, J. Rose, L. Sanders, M. Seremetkoska, H. Setio, S. Shone, P. Shrestha, C. Singh, C. Singleton, N. Stoyanov, S. Sutcliffe, K. Swaraj, J. Tarrant, S. Thompson, I.M. Tsay, M. Vorster, A. Waldman, L. Wallis, E. Wilford, K. Wong, S.J. Connolly, A. Spyropoulos, J. Eikelboom, R. Luton, M. Gupta, A.S. Pandey, S. Cheung, R. Leader, P. Beaudry, F. Ayala-Paredes, J. Berlingieri, J. Heath, G. Poirier, M. Du Preez, R. Nadeau, G. Dresser, R. Dhillon, T. Hruczkowski, B. Schweitzer, B. Coutu, P. Angaran, P. MacDonald, S. Vizel, S. Fikry, R. Parkash, A. Lavoie, J. Cha, B. Ramjattan, J. Bonet, K. Ahmad, L. Aro, T. Aves, K. Beaudry, C. Bergeron, J. Bigcanoe, N. Bignell, L. Breakwell, E. Burke, L. Carroll, B. Clarke, T. Cleveland, S. Daheb, P. Dehghani, I. Denis, Z. Djaidani, P. Dorian, S. Douglass, J. Dunnigan, A. Ewert, D. Farquhar, A. Fearon, L. Ferleyko, D. Fournier, B. Fox, M.-C. Grenier, W. Gulliver, K. Haveman, C. Hines, K. Hines, A.M. Jackson, C. Jean, G. Jethoo, R. Kahlon, S. Kelly, R. Kim, V. Korley, J. Kornder, L. Kwan, J. Largy, C. Lewis, S. Lewis, I. Mangat, R. Moor, J. Navratil, I. Neas, J. Otis, R. Otis, M. Pandey, F. Petrie, A. Pinter, M. Raines, P. Roberts, M. Robinson, G. Sas, S. Schulman, L. Snell, S. Spearson, J. Stevenson, T. Trahey, S. Wong, D. Wright, H. Ragy, A. Abd El-Aziz, S.K. Abou Seif, M.G. El Din, S. El Etriby, A. Elbahry, A. El-Etreby, M. Elkhadem, A. Katta, T. Khairy, A. Mowafy, M. Nawar, A. Ohanissian, A. Reda, M. Reda, H. Salem, N. Sami, S. Samir, M. Setiha, M. Sobhy, A. Soliman, N. Taha, M. Tawfik, E. Zaatout, D. Kettles, J. Bayat, H. Siebert, A. Horak, Y. Kelfkens, R. Garda, T. Pillay, M. Guerra, L. van Zyl, H. Theron, A. Murray, R. Louw, D. Greyling, P. Mntla, V. Ueckermann, R. Loghdey, S. Ismail, F. Ahmed, J. Engelbrecht, A. Ramdass, S. Maharajh, W. Oosthuysen, G. Angel, C. Bester, M. Booysen, C. Boshoff, C. Cannon, S. Cassimjee, C. Chami, G. Conway, A. Davids, L. de Meyer, G. Du Plessis, T. Ellis, L. Henley, M. Karsten, E. Loyd, J. Marks, L. Mavhusa, M. Mostert, A. Page, L. Rikhotso, M. Salie, J. Sasto, F. Shaik, A. Skein, L. Smith, G. Tarr, T. Tau, F. van Zyl, W. Al Mahmeed, G. Yousef, A. Agrawal, M. Nathani, M. Ibrahim, E.M. Esheiba, R. Singh, A. Naguib, M. Abu-Mahfouz, M. Al Omairi, A. Al Naeemi, R. Maruthanayagam, N. Bazargani, A. Wassef, R. Gupta, M. Khan, B. Subbaraman, A. Abdul, A. Al Mulla, S. El Bardisy, P. Haridas, S. Jadhav, K. Magdaluyo, M. Makdad, I. Maqsood, R. Mohamed, N. Sharma, R. Sharma, M. Thanzeel, S.Z. Goldhaber, R. Canosa, P. Rama, E. Blumberg, J. Garcia, P. Mullen, V. Wilson, A. Quick, K. Ferrick, W.M. Kutayli, M. Cox, M. Franco, S. Falkowski, R. Mendelson, M. Williams, S. Miller, S. Beach, A. Alfieri, T. Gutowski, I. Haque, R. Reddy, W. Ahmed, P. Delafontaine, D. Diercks, D. Theodoro, K. Remmel, M. Alberts, R. Ison, H. Noveck, P. Duffy, S. Pitta, D. Nishijima, C. Treasure, N. Asafu-Adjaye, K. Ball, M. Bartlett, M. Bentley, S. Bowers, A. Brown, A. Browne, J. Cameron-Watts, M. Canova, D. Cassidy, K. Cervellione, S. Congal, J. DePauw, A. Dickerson, M. Eley, L. Evans, S. Felpel, K. Ferdinand, D. Fielder, P. Gentry, A. Haideri, F. Hakimi, T. Harbour, E. Hartranft, B. Hawkins, M. Headlee, L. Henson, C. Herrick, T. Hicks, S. Jasinski, A. Jones, L. Jones, P. Jones, S. Karl, M. Keeling, J. Kerr, P. Knowles, J. Langdon, M. Lay, J.A. Lee, T. Lincoln, E. Malone, A. Merliss, D. Merritt, J. Minardo, B. Mooso, C. Orosco, V. Palumbo, M. Parker, T. Parrott, S. Paserchia, G. Pearl, J. Peterson, N. Pickelsimer, T. Purcell, J. Raynor, S. Raziano, C. Richard, T. Richardson, C. Robertson, A. Sage, T. Sanghera, P. Shaw, J. Shoemaker, K. Smith, B. Stephanie, A. Thatcher, H. Theobald, N. Thompson, L. Treasure, T. Tripti, C. Verdi, and V. Worthy

Subjects
Surgery, RD1-811, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P

Published
2018
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34. Prompt and nonprompt J/ψ production and nuclear modification in pPb collisions at sNN=8.16 TeV

Author

R. Aaij, B. Adeva, M. Adinolfi, Z. Ajaltouni, S. Akar, J. Albrecht, F. Alessio, M. Alexander, A. Alfonso Albero, S. Ali, G. Alkhazov, P. Alvarez Cartelle, A.A. Alves, Jr, S. Amato, S. Amerio, Y. Amhis, L. An, L. Anderlini, G. Andreassi, M. Andreotti, J.E. Andrews, R.B. Appleby, F. Archilli, P. d'Argent, J. Arnau Romeu, A. Artamonov, M. Artuso, E. Aslanides, G. Auriemma, M. Baalouch, I. Babuschkin, S. Bachmann, J.J. Back, A. Badalov, C. Baesso, S. Baker, V. Balagura, W. Baldini, A. Baranov, R.J. Barlow, C. Barschel, S. Barsuk, W. Barter, F. Baryshnikov, M. Baszczyk, V. Batozskaya, V. Battista, A. Bay, L. Beaucourt, J. Beddow, F. Bedeschi, I. Bediaga, A. Beiter, L.J. Bel, N. Beliy, V. Bellee, N. Belloli, K. Belous, I. Belyaev, E. Ben-Haim, G. Bencivenni, S. Benson, S. Beranek, A. Berezhnoy, R. Bernet, D. Berninghoff, E. Bertholet, A. Bertolin, C. Betancourt, F. Betti, M.-O. Bettler, M. van Beuzekom, Ia. Bezshyiko, S. Bifani, P. Billoir, A. Birnkraut, A. Bitadze, A. Bizzeti, M.B. Bjoern, T. Blake, F. Blanc, J. Blouw, S. Blusk, V. Bocci, T. Boettcher, A. Bondar, N. Bondar, W. Bonivento, I. Bordyuzhin, A. Borgheresi, S. Borghi, M. Borisyak, M. Borsato, M. Borysova, F. Bossu, M. Boubdir, T.J.V. Bowcock, E. Bowen, C. Bozzi, S. Braun, T. Britton, J. Brodzicka, D. Brundu, E. Buchanan, C. Burr, A. Bursche, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, R. Calladine, M. Calvi, M. Calvo Gomez, A. Camboni, P. Campana, D.H. Campora Perez, L. Capriotti, A. Carbone, G. Carboni, R. Cardinale, A. Cardini, P. Carniti, L. Carson, K. Carvalho Akiba, G. Casse, L. Cassina, L. Castillo Garcia, M. Cattaneo, G. Cavallero, R. Cenci, D. Chamont, M. Charles, Ph. Charpentier, G. Chatzikonstantinidis, M. Chefdeville, S. Chen, S.F. Cheung, S.-G. Chitic, V. Chobanova, M. Chrzaszcz, A. Chubykin, X. Cid Vidal, G. Ciezarek, P.E.L. Clarke, M. Clemencic, H.V. Cliff, J. Closier, V. Coco, J. Cogan, E. Cogneras, V. Cogoni, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, A. Contu, A. Cook, G. Coombs, S. Coquereau, G. Corti, M. Corvo, C.M. Costa Sobral, B. Couturier, G.A. Cowan, D.C. Craik, A. Crocombe, M. Cruz Torres, R. Currie, C. D'Ambrosio, F. Da Cunha Marinho, E. Dall'Occo, J. Dalseno, A. Davis, O. De Aguiar Francisco, K. De Bruyn, S. De Capua, M. De Cian, J.M. De Miranda, L. De Paula, M. De Serio, P. De Simone, C.T. Dean, D. Decamp, L. Del Buono, H.-P. Dembinski, M. Demmer, A. Dendek, D. Derkach, O. Deschamps, F. Dettori, B. Dey, A. Di Canto, P. Di Nezza, H. Dijkstra, F. Dordei, M. Dorigo, A. Dosil Suárez, L. Douglas, A. Dovbnya, K. Dreimanis, L. Dufour, G. Dujany, K. Dungs, P. Durante, R. Dzhelyadin, M. Dziewiecki, A. Dziurda, A. Dzyuba, N. Déléage, S. Easo, M. Ebert, U. Egede, V. Egorychev, S. Eidelman, S. Eisenhardt, U. Eitschberger, R. Ekelhof, L. Eklund, S. Ely, S. Esen, H.M. Evans, T. Evans, A. Falabella, N. Farley, S. Farry, R. Fay, D. Fazzini, L. Federici, D. Ferguson, G. Fernandez, P. Fernandez Declara, A. Fernandez Prieto, F. Ferrari, F. Ferreira Rodrigues, M. Ferro-Luzzi, S. Filippov, R.A. Fini, M. Fiore, M. Fiorini, M. Firlej, C. Fitzpatrick, T. Fiutowski, F. Fleuret, K. Fohl, M. Fontana, F. Fontanelli, D.C. Forshaw, R. Forty, V. Franco Lima, M. Frank, C. Frei, J. Fu, W. Funk, E. Furfaro, C. Färber, E. Gabriel, A. Gallas Torreira, D. Galli, S. Gallorini, S. Gambetta, M. Gandelman, P. Gandini, Y. Gao, L.M. Garcia Martin, J. García Pardiñas, J. Garra Tico, L. Garrido, P.J. Garsed, D. Gascon, C. Gaspar, L. Gavardi, G. Gazzoni, D. Gerick, E. Gersabeck, M. Gersabeck, T. Gershon, Ph. Ghez, S. Gianì, V. Gibson, O.G. Girard, L. Giubega, K. Gizdov, V.V. Gligorov, D. Golubkov, A. Golutvin, A. Gomes, I.V. Gorelov, C. Gotti, E. Govorkova, J.P. Grabowski, R. Graciani Diaz, L.A. Granado Cardoso, E. Graugés, E. Graverini, G. Graziani, A. Grecu, R. Greim, P. Griffith, L. Grillo, L. Gruber, B.R. Gruberg Cazon, O. Grünberg, E. Gushchin, Yu. Guz, T. Gys, C. Göbel, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, S.C. Haines, B. Hamilton, X. Han, T. Hancock, S. Hansmann-Menzemer, N. Harnew, S.T. Harnew, J. Harrison, C. Hasse, M. Hatch, J. He, M. Hecker, K. Heinicke, A. Heister, K. Hennessy, P. Henrard, L. Henry, E. van Herwijnen, M. Heß, A. Hicheur, D. Hill, C. Hombach, P.H. Hopchev, Z.-C. Huard, W. Hulsbergen, T. Humair, M. Hushchyn, D. Hutchcroft, P. Ibis, M. Idzik, P. Ilten, R. Jacobsson, J. Jalocha, E. Jans, A. Jawahery, F. Jiang, M. John, D. Johnson, C.R. Jones, C. Joram, B. Jost, N. Jurik, S. Kandybei, M. Karacson, J.M. Kariuki, S. Karodia, M. Kecke, M. Kelsey, M. Kenzie, T. Ketel, E. Khairullin, B. Khanji, C. Khurewathanakul, T. Kirn, S. Klaver, K. Klimaszewski, T. Klimkovich, S. Koliiev, M. Kolpin, I. Komarov, R. Kopecna, P. Koppenburg, A. Kosmyntseva, S. Kotriakhova, M. Kozeiha, L. Kravchuk, M. Kreps, P. Krokovny, F. Kruse, W. Krzemien, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, A.K. Kuonen, K. Kurek, T. Kvaratskheliya, D. Lacarrere, G. Lafferty, A. Lai, G. Lanfranchi, C. Langenbruch, T. Latham, C. Lazzeroni, R. Le Gac, J. van Leerdam, A. Leflat, J. Lefrançois, R. Lefèvre, F. Lemaitre, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, T. Li, Y. Li, Z. Li, T. Likhomanenko, R. Lindner, F. Lionetto, X. Liu, D. Loh, I. Longstaff, J.H. Lopes, D. Lucchesi, M. Lucio Martinez, H. Luo, A. Lupato, E. Luppi, O. Lupton, A. Lusiani, X. Lyu, F. Machefert, F. Maciuc, V. Macko, P. Mackowiak, B. Maddock, S. Maddrell-Mander, O. Maev, K. Maguire, D. Maisuzenko, M.W. Majewski, S. Malde, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, P. Manning, D. Marangotto, J. Maratas, J.F. Marchand, U. Marconi, C. Marin Benito, M. Marinangeli, P. Marino, J. Marks, G. Martellotti, M. Martin, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, D. Martins Tostes, L.M. Massacrier, A. Massafferri, R. Matev, A. Mathad, Z. Mathe, C. Matteuzzi, A. Mauri, E. Maurice, B. Maurin, A. Mazurov, M. McCann, A. McNab, R. McNulty, J.V. Mead, B. Meadows, C. Meaux, F. Meier, N. Meinert, D. Melnychuk, M. Merk, A. Merli, E. Michielin, D.A. Milanes, E. Millard, M.-N. Minard, L. Minzoni, D.S. Mitzel, A. Mogini, J. Molina Rodriguez, T. Mombacher, I.A. Monroy, S. Monteil, M. Morandin, M.J. Morello, O. Morgunova, J. Moron, A.B. Morris, R. Mountain, F. Muheim, M. Mulder, M. Mussini, D. Müller, J. Müller, K. Müller, V. Müller, P. Naik, T. Nakada, R. Nandakumar, A. Nandi, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, M. Neuner, T.D. Nguyen, C. Nguyen-Mau, S. Nieswand, R. Niet, N. Nikitin, T. Nikodem, A. Nogay, D.P. O'Hanlon, A. Oblakowska-Mucha, V. Obraztsov, S. Ogilvy, R. Oldeman, C.J.G. Onderwater, A. Ossowska, J.M. Otalora Goicochea, P. Owen, A. Oyanguren, P.R. Pais, A. Palano, M. Palutan, A. Papanestis, M. Pappagallo, L.L. Pappalardo, C. Pappenheimer, W. Parker, C. Parkes, G. Passaleva, A. Pastore, M. Patel, C. Patrignani, A. Pearce, A. Pellegrino, G. Penso, M. Pepe Altarelli, S. Perazzini, P. Perret, L. Pescatore, K. Petridis, A. Petrolini, A. Petrov, M. Petruzzo, E. Picatoste Olloqui, B. Pietrzyk, M. Pikies, D. Pinci, A. Pistone, A. Piucci, V. Placinta, S. Playfer, M. Plo Casasus, T. Poikela, F. Polci, M. Poli Lener, A. Poluektov, I. Polyakov, E. Polycarpo, G.J. Pomery, S. Ponce, A. Popov, D. Popov, S. Poslavskii, C. Potterat, E. Price, J. Prisciandaro, C. Prouve, V. Pugatch, A. Puig Navarro, H. Pullen, G. Punzi, W. Qian, R. Quagliani, B. Quintana, B. Rachwal, J.H. Rademacker, M. Rama, M. Ramos Pernas, M.S. Rangel, I. Raniuk, F. Ratnikov, G. Raven, M. Ravonel Salzgeber, M. Reboud, F. Redi, S. Reichert, A.C. dos Reis, C. Remon Alepuz, V. Renaudin, S. Ricciardi, S. Richards, M. Rihl, K. Rinnert, V. Rives Molina, P. Robbe, A.B. Rodrigues, E. Rodrigues, J.A. Rodriguez Lopez, P. Rodriguez Perez, A. Rogozhnikov, S. Roiser, A. Rollings, V. Romanovskiy, A. Romero Vidal, J.W. Ronayne, M. Rotondo, M.S. Rudolph, T. Ruf, P. Ruiz Valls, J. Ruiz Vidal, J.J. Saborido Silva, E. Sadykhov, N. Sagidova, B. Saitta, V. Salustino Guimaraes, D. Sanchez Gonzalo, C. Sanchez Mayordomo, B. Sanmartin Sedes, R. Santacesaria, C. Santamarina Rios, M. Santimaria, E. Santovetti, G. Sarpis, A. Sarti, C. Satriano, A. Satta, D.M. Saunders, D. Savrina, S. Schael, M. Schellenberg, M. Schiller, H. Schindler, M. Schlupp, M. Schmelling, T. Schmelzer, B. Schmidt, O. Schneider, A. Schopper, H.F. Schreiner, K. Schubert, M. Schubiger, M.-H. Schune, R. Schwemmer, B. Sciascia, A. Sciubba, A. Semennikov, A. Sergi, N. Serra, J. Serrano, L. Sestini, P. Seyfert, M. Shapkin, I. Shapoval, Y. Shcheglov, T. Shears, L. Shekhtman, V. Shevchenko, B.G. Siddi, R. Silva Coutinho, L. Silva de Oliveira, G. Simi, S. Simone, M. Sirendi, N. Skidmore, T. Skwarnicki, E. Smith, I.T. Smith, J. Smith, M. Smith, l. Soares Lavra, M.D. Sokoloff, F.J.P. Soler, B. Souza De Paula, B. Spaan, P. Spradlin, S. Sridharan, F. Stagni, M. Stahl, S. Stahl, P. Stefko, S. Stefkova, O. Steinkamp, S. Stemmle, O. Stenyakin, H. Stevens, S. Stone, B. Storaci, S. Stracka, M.E. Stramaglia, M. Straticiuc, U. Straumann, L. Sun, W. Sutcliffe, K. Swientek, V. Syropoulos, M. Szczekowski, T. Szumlak, M. Szymanski, S. T'Jampens, A. Tayduganov, T. Tekampe, G. Tellarini, F. Teubert, E. Thomas, J. van Tilburg, M.J. Tilley, V. Tisserand, M. Tobin, S. Tolk, L. Tomassetti, D. Tonelli, S. Topp-Joergensen, F. Toriello, R. Tourinho Jadallah Aoude, E. Tournefier, M. Traill, M.T. Tran, M. Tresch, A. Trisovic, A. Tsaregorodtsev, P. Tsopelas, A. Tully, N. Tuning, A. Ukleja, A. Ustyuzhanin, U. Uwer, C. Vacca, A. Vagner, V. Vagnoni, A. Valassi, S. Valat, G. Valenti, R. Vazquez Gomez, P. Vazquez Regueiro, S. Vecchi, M. van Veghel, J.J. Velthuis, M. Veltri, G. Veneziano, A. Venkateswaran, T.A. Verlage, M. Vernet, M. Vesterinen, J.V. Viana Barbosa, B. Viaud, D. Vieira, M. Vieites Diaz, H. Viemann, X. Vilasis-Cardona, M. Vitti, V. Volkov, A. Vollhardt, B. Voneki, A. Vorobyev, V. Vorobyev, C. Voß, J.A. de Vries, C. Vázquez Sierra, R. Waldi, C. Wallace, R. Wallace, J. Walsh, J. Wang, D.R. Ward, H.M. Wark, N.K. Watson, D. Websdale, A. Weiden, M. Whitehead, J. Wicht, G. Wilkinson, M. Wilkinson, M. Williams, M.P. Williams, T. Williams, F.F. Wilson, J. Wimberley, M.A. Winn, J. Wishahi, W. Wislicki, M. Witek, G. Wormser, S.A. Wotton, K. Wraight, K. Wyllie, Y. Xie, Z. Xu, Z. Yang, Y. Yao, H. Yin, J. Yu, X. Yuan, O. Yushchenko, K.A. Zarebski, M. Zavertyaev, L. Zhang, Y. Zhang, A. Zhelezov, Y. Zheng, X. Zhu, V. Zhukov, J.B. Zonneveld, and S. Zucchelli

Subjects
Physics, QC1-999
Abstract

The production of J/ψ mesons is studied in proton-lead collisions at the centre-of-mass energy per nucleon pair sNN=8.16 TeV with the LHCb detector at the LHC. The double differential cross-sections of prompt and nonprompt J/ψ production are measured as a function of the J/ψ transverse momentum and rapidity in the nucleon–nucleon centre-of-mass frame. Forward-to-backward ratios and nuclear modification factors are determined. The results are compared with theoretical calculations based on collinear factorisation using nuclear parton distribution functions, on the colour glass condensate or on coherent energy loss models.

Published
2017
Full Text
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36. Usefulness of serum neurofilament light chain in chronic inflammatory demyelinating polyradiculoneuropathy.

Author

Llauradó A, García-Carmona C, Restrepo-Vera JL, Alemañ J, Salvadó M, Sanchez-Tejerina D, Sotoca J, Seoane JL, Lainez E, Gratacós-Viñola M, Vidal-Taboada JM, Fissolo N, Comabella M, Raguer N, and Juntas-Morales R

Abstract

Background: The development of new biomarkers is essential to improve diagnostic accuracy and guide treatment decisions in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The aim of this study was to investigate the utility of the serum neurofilament light chain (sNfL) level as a marker for disability and response to immunomodulatory treatment in patients with CIDP., Methods: This prospective, single-center, observational study included 38 patients with CIDP: 19 treatment-naive (CIDP-I) patients assessed before and after the initiation of immunomodulatory therapy and 19 stable patients on maintenance immunoglobulins (CIDP-M). Clinical scales (INCAT, I-RODS, MRC-SS and grip strength) were used to assess disability and treatment response. Nerve conduction study data were collected., Results: The median sNfL level (pg/mL) was greater in CIDP-I patients than in CIDP-M patients (23.4 vs. 7.7; p = 0.002). A reduction in sNfL levels was observed in CIDP-I patients after 5 months of immunomodulatory treatment (23.4 vs. 15.0; p = 0.001). sNfL levels were correlated with greater disability as assessed by the INCAT (p = 0.007), I-RODS (p = 0.004), and MRC-SS (p = 0.016) in treatment-naive patients but not in those receiving maintenance therapy. sNfL levels correlated with the average amplitude of the distal compound muscle action potential of the median, ulnar, peroneal and tibial nerves from the most affected limb (p = 0.043)., Conclusions: sNfL levels are significantly reduced in patients with CIDP who respond to immunomodulatory treatment and are positively correlated with disability. These findings highlight the utility of sNfL as a marker of disease activity and treatment response in patients with CIDP., Competing Interests: Declaration of competing interest The authors report no disclosures relevant to the manuscript., (Copyright © 2025 Elsevier B.V. All rights reserved.)

Published
2025
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38. To the Editor-Electrical impulse conduction through superior septal connections as a mechanism to bundle branch block correction is a verifiable assumption.

Author

Mahmud R, Sanchez-Quintana D, Macias Y, de Almeida MC, Anderson RH, and Back Sternick E

Subjects
Humans, Electrocardiography, Heart Septum physiopathology, Bundle of His physiopathology, Bundle-Branch Block physiopathology, Bundle-Branch Block diagnosis, Bundle-Branch Block therapy, Heart Conduction System physiopathology
Abstract

Competing Interests: Disclosures The authors have no conflicts of interest to disclose.

Published
2024
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39. Outcomes in studies regarding older patients with prostate cancer: A systematic review.

Author

Jochems KFT, Menges D, Sanchez D, de Glas NA, Wildiers H, Eberli D, Puhan MA, and Bastiaannet E

Subjects
Humans, Male, Aged, Aged, 80 and over, Disease Progression, Outcome Assessment, Health Care, Age Factors, Prostatic Neoplasms therapy, Prostatic Neoplasms mortality, Quality of Life
Abstract

Introduction: Older patients are often deemed ineligible for clinical research, and many frequently-used endpoints and outcome measures are not as relevant for older patients for younger ones. This systematic review aimed to present an overview of outcomes used in clinical research regarding patients over the age of 65 years with prostate cancer., Materials and Methods: PubMed and Embase were systematically searched to identify studies on prostate cancer (treatment) in patients aged ≥65 between 2016 and 2023. Data on title, study design, number of participants and age, stage of disease, treatment, and investigated outcomes were synthesized and descriptively analyzed., Results: Sixty-eight studies were included. Of these most included patients over 65 years, while others used a higher age. Overall, 39 articles (57.3%) reported on survival-related outcomes, 22 (32.4%) reported on progression of disease and 38 (55.9%) used toxicity or adverse events as an outcome measure. Health-related quality of life and functional outcomes were investigated in 29.4%, and cognition in two studies. The most frequently investigated survival-related outcomes were overall and cancer-specific survival (51.3%); however, 38.5% only studied overall survival., Discussion: The main focus of studies included in this review remains survival and disease progression. There is limited attention for health-related quality of life and functional status, although older patients often prioritize the latter. Future research should incorporate outcome measures tailored to the aged population to improve care for older patients with prostate cancer., Competing Interests: Declaration of Competing Interest No conflict of interest for all authors., (Copyright © 2024. Published by Elsevier Ltd.)

Published
2024
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40. Correction of bundle branch block by so-called nonselective His bundle pacing: The potential role of accessory connections in the ventricular septal crest.

Author

Mahmud R, Sanchez-Quintana D, Macias Y, de Almeida MC, Anderson RH, and Back Sternick E

Subjects
Humans, Accessory Atrioventricular Bundle physiopathology, Bundle of His physiopathology, Bundle-Branch Block physiopathology, Bundle-Branch Block therapy, Cardiac Pacing, Artificial methods, Electrocardiography, Ventricular Septum
Abstract

Competing Interests: Disclosures We have no conflicts of interest to disclose.

Published
2024
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41. State health departments leverage pharmacy partnerships across the nation to advance diabetes care initiatives.

Author

Montierth R, Bing M, Sanchez-Torres D, Mahajan P, Alexander J, and Gearing MJ

Subjects
Humans, United States, Public Health, Centers for Disease Control and Prevention, U.S., Professional Role, Pharmacies organization & administration, State Government, Cooperative Behavior, Diabetes Mellitus, Type 2 prevention & control, Pharmacists organization & administration
Abstract

Background: In 2018, the Centers for Disease Control and Prevention (CDC)'s Division of Diabetes Translation (DDT) initiated a 5-year cooperative agreement funding opportunity with departments of health in every state and the District of Columbia. The funded recipients pursued activities that strengthened diabetes management and type 2 diabetes prevention interventions within their jurisdictions. An option to involve the pharmacy sector in their diabetes-related interventions was available., Objectives: This research aims to understand who public health departments partnered with in the pharmacy sector and identify the types of activities pursued together to expand access to diabetes-related interventions., Methods: A review of annual work plans and progress reports submitted to CDC by recipients during the first 4 years of the funding cycle was conducted. Descriptions of work conducted in partnership with pharmacies, pharmacists, or pharmacy organizations were flagged for review, coding, and analysis., Results: Of the 51 public health department recipients, 48 collaborated with pharmacy partners within their jurisdictions. Activities were developed and carried out in ways that utilized the pharmacy workforce to support public health diabetes initiatives, such as the development and delivery of diabetes self-management education and support and type 2 diabetes prevention programs in pharmacies (68.8%), delivery of diabetes-related training for the pharmacy workforce (91.7%), and support of billing and sustainability efforts for pharmacy-based diabetes services (52.1%)., Conclusion: State public health department diabetes program personnel cultivated productive relationships with a variety of members of the pharmacy workforce. Through these partnerships, they leveraged one another's resources, expertise, and mutual determination to prepare and carry out diabetes-related interventions within their states. This document provides pharmacists and pharmacy decision-makers with foundational knowledge that can lead to increased engagement with public health partners to expand diabetes management and prevention services in pharmacy settings., Competing Interests: Disclosure The authors have no conflicts of interest to disclose., (Published by Elsevier Inc.)

Published
2024
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42. Quantifying the effect of cerebral atrophy on head injury risk in elderly individuals: Insights from computational biomechanics and experimental analysis of bridging veins.

Author

Abdi H, Sanchez-Molina D, Garcia-Vilana S, and Rahimi-Movaghar V

Subjects
Humans, Aged, Biomechanical Phenomena, Brain, Atrophy, Finite Element Analysis, Craniocerebral Trauma complications, Craniocerebral Trauma diagnostic imaging, Brain Injuries
Abstract

The objective of this study was to quantitatively investigate the relationship between cerebral atrophy and the risk of injury in elderly individuals. To achieve this, a sophisticated computational biomechanics approach utilizing finite element analysis was employed to simulate the mechanical behavior of the brain and skull under various conditions. In addition, particular emphasis was placed on understanding the role of cerebral bridging veins (BVs) and their mechanical properties at different ages in the occurrence of head injuries. Head models representing healthy brains and five atrophy models were developed based on imaging data. After validation, the models underwent the identical impact loading conditions to enable the simulation of brain damage. The resulting outcomes of the models with brain atrophy were then compared to the results obtained from the healthy model, allowing for a comparative analysis. Simulations showed increased relative displacement with worsening brain atrophy, particularly in the frontal and occipital regions. Compared to the healthy brain model, relative displacement increased by 2.36 %-9.21 % in the atrophy models, indicating an elevated risk of injury. In severe brain atrophy (FEM 6), the strain reached 83.59 % in local model simulations, leading to damage and rupture of cerebral BVs in both young and elderly individuals. Mechanical tests on cerebral BVs demonstrated a negative correlation between age and ultimate force, stress, and strain, suggesting increased susceptibility to damage with age. An observed sharp decline of approximately 50 % in ultimate stress and 35 % in ultimate strain was noted as age increased. We implemented a 50 % reduction in the intensity of head impact forces; nevertheless, vascular damage continues to manifest in the elderly population. To establish a truly safe zone, it is imperative to further decrease the intensity of the impact. This investigation represents a significant step forward in our understanding of the complex interplay between cerebral atrophy, the mechanical properties of BVs at different age, and the risk of head injury in the elderly. Through continued research in this field, we can strive to improve the quality of care, enhance prevention strategies, and ultimately enhance the well-being and safety of the elderly population., Competing Interests: Declaration of Competing Interest We hereby confirm that there is no conflict of interest in this study., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Published
2023
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43. The Patient-Reported Outcomes Measurement Information System (PROMIS) pediatric and parent-proxy short forms for anxiety: Psychometric properties in the Kids FACE FEARS sample.

Author

Freitag GF, Salem H, Conroy K, Busto C, Adrian M, Borba CPC, Brandt A, Chu PV, Dantowitz A, Farley AM, Fortuna L, Furr JM, Lejeune J, Miller L, Platt R, Porche M, Read KL, Rivero-Conil S, Hernandez RDS, Shumway P, Sikov J, Spencer A, Syeda H, McLellan LF, Rapee RM, McMakin D, Pincus DB, and Comer JS

Subjects
Adolescent, Humans, Child, Psychometrics, Reproducibility of Results, Surveys and Questionnaires, Fear, Parents, Patient Reported Outcome Measures, Information Systems, Quality of Life, Anxiety
Abstract

There is tremendous need for brief and supported, non-commercial youth- and caregiver-report questionnaires of youth anxiety. The pediatric and parent proxy short forms of the Patient-Reported Outcomes Measurement Information System (PROMIS) Anxiety scale (8a v2.0) are free, brief, publicly accessible measures of youth- and caregiver-reported anxiety in children and adolescents. Despite increased use of the PROMIS, no study has evaluated performance of its anxiety scales in a sample of treatment-engaged anxious youth. Analyses were conducted on baseline data from the first 265 families (child M Age =11.14 years, 70% racial/ethnic minoritized youth) to enroll in the Kids FACE FEARS trial, a multisite comparative effectiveness trial of therapist-led vs. self-administered treatment for elevated youth anxiety. Confirmatory factor analysis (CFA) examined factor structure; omega coefficients and regression models examined internal consistency, convergent validity, and cross-informant reliability. CFA supported adjusted single-factor solutions across youth and caregiver reports, and internal consistency was high. Convergent validity was supported by medium-to-large associations with anxiety-related impairment and severity. Moderate cross-informant reliability between reports was found. Results showcase the first psychometric study of the PROMIS Anxiety scale short forms among treatment-engaged youth with elevated anxiety. Findings highlight the PROMIS Anxiety scale's utility in typical care settings for youth anxiety., (Published by Elsevier Ltd.)

Published
2023
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45. Congenital infection of SARS-CoV-2 in live-born neonates: a population-based descriptive study.

Author

Garcia-Ruiz I, Sulleiro E, Serrano B, Fernandez-Buhigas I, Rodriguez-Gomez L, Sanchez-Nieves Fernandez D, Anton-Pagarolas A, Esperalba-Esquerra J, Frick MA, Camba F, Navarro-Jimenez A, Fernandez-Hidalgo N, Maiz N, Carreras E, and Suy A

Subjects
Adolescent, Adult, Amniotic Fluid virology, COVID-19 virology, Female, Fetal Blood virology, Humans, Infant, Newborn, Middle Aged, Nasopharynx virology, Placenta virology, Pregnancy, Spain epidemiology, Tertiary Care Centers, Young Adult, COVID-19 congenital, Infectious Disease Transmission, Vertical, Pregnancy Complications, Infectious virology, SARS-CoV-2 isolation & purification
Abstract

Objective: To evaluate the evidence of mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)., Methods: This is a descriptive, multicentre, observational study in nine tertiary care hospitals throughout Spain. The study population was women with coronavirus disease 2019 during pregnancy. Mother-to-child transmission was defined as positive real-time RT-PCR of SARS-CoV-2 in amniotic fluid, cord blood, placenta or neonatal nasopharyngeal swabs taken immediately after birth., Results: We included 43 women with singleton pregnancies and one with a twin pregnancy, as a result we obtained 45 samples of placenta, amniotic fluid and umbilical cord blood. The median gestational age at diagnosis was 34.7 weeks (range 14-41.3 weeks). The median interval between positive RT-PCR and delivery was 21.5 days (range 0-141 days). Fourteen women (31.8%, 95% CI 18.6%-47.6%) were positive at the time of delivery. There was one singleton pregnancy with SARS-CoV-2 RT-PCR positive in the placenta, amniotic fluid and umbilical cord blood (2.2%, 95% CI 0.1%-11.8%). Nasopharyngeal aspiration was performed on 38 neonates at birth, all of which were negative (0%, 95% CI 0%-9.3%). In 11 neonates the nasopharyngeal aspiration was repeated at 24-48 hours, and one returned positive (9.1%, 95% CI 0.2%-41.3%)., Conclusions: The presence of SARS-CoV-2 in placenta, amniotic fluid and cord blood shows that mother-to-child transmission is possible but uncommon., (Copyright © 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)

Published
2021
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46. Prediction of 5-year mortality risk by malnutrition according to the GLIM format using seven pragmatic approaches to define the criterion of loss of muscle mass.

Author

Sanchez-Rodriguez D, Locquet M, Bruyère O, Lengelé L, Cavalier E, Reginster JY, and Beaudart C

Subjects
Aged, Aging, Anthropometry, Belgium epidemiology, Body Mass Index, Cohort Studies, Female, Hand Strength, Humans, Independent Living, Male, Malnutrition epidemiology, Nutrition Assessment, Risk Factors, Malnutrition diagnosis, Malnutrition mortality, Mass Screening methods, Sarcopenia diagnosis
Abstract

Objectives: To assess the association between baseline malnutrition according to the GLIM format, using seven pragmatic approaches to define the criterion of loss of muscle mass, with mortality in the SarcoPhAge (Sarcopenia and Physical Impairment with advancing Age) study during a 5-year follow-up. Secondarily, to calculate diagnostic performance indicators, concordance, and feasibility of these 7 pragmatic approaches compared to the original GLIM criteria., Methods: Post-hoc analysis of the SarcoPhAge cohort, which included 534 community-dwelling volunteers ≥65-year-old, followed-up from 2013 to 2019. Baseline malnutrition was defined by GLIM criteria and 7 approaches: 1) Omission of a reduced muscle mass as a criterion; 2) Substitution for handgrip strength, 3) Calf-circumference, 4) Mid-arm circumference, 5) Goodman's grid, 6) Ishii's score chart, and 7) Yu's formula. The association between malnutrition (according to GLIM criteria and the 7 approaches) and mortality was assessed by Cox-regressions. Sensitivity, Specificity, Positive (PPV), Negative (NPV) predictive values, area under the curve (AUC), Cohen-kappa coefficient, and TELOS-feasibility score were calculated., Results: Data to calculate GLIM criteria were available for 373 subjects (73.07 ± 5.96 years, 56% women). Prevalence of malnutrition with GLIM criteria was 24.4% (ranged from 13.9% to 20.9% with the 7 approaches). GLIM criteria showed a HR = 3.38 (1.89-6.09) to predict mortality during the 5-year follow-up, which ranged from HR = 2.72 (1.51-4.91) to 3.94 (2.14-7.24) with the 7 approaches. All 7 approaches were feasible (TELOS ≥ 3), showed sensitivity ≥ 65%, specificity ≥ 95.4%, PPV ≥ 85%, NPV ≥ 88%, AUC ≥ 0.7 and had almost-perfect/strong concordance (k ≥ 0.7) with the original GLIM criteria., Conclusions: GLIM criteria and the 7 approaches predicted three-to four-fold mortality, all ensured an accurate diagnosis, and were feasible in clinical settings., Competing Interests: Conflict of Interest All authors declare they do not have any financial and personal relationships with other people or organizations that could inappropriately influence their work., (Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)

Published
2021
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47. SURFWET: A biokinetic model for surface flow constructed wetlands.

Author

Aragones DG, Sanchez-Ramos D, and Calvo GF

Subjects
Nitrogen analysis, Phosphorus, Wastewater, Waste Disposal, Fluid, Wetlands
Abstract

Constructed wetlands are an alternative biotechnology for wastewater treatment that have several advantages over conventional systems. In this work, a biokinetic model for surface flow constructed wetlands is presented (SURFWET). SURFWET belongs to a class of models that are not only interesting from a theoretical viewpoint, as they allow to improve the understanding of the underlying processes; but also from a practical viewpoint, because they can be useful for optimal designs of constructed wetlands, complementing current empirical methods. The proposed model is centered on the intervening physical and biochemical processes involved in pollutant removal in wastewater (organic matter, nitrogen, phosphorus, suspended solids), capturing the interplay of the main agents on contaminant removal (bacteria, macrophytes and phytoplankton). Furthermore, the hydraulic model considers water volume as a variable depending on the outlet hydraulic capacity, and dissolved oxygen has also been introduced as a key driver of reaction kinetics of wetlands. Beyond putting forward a theoretical framework, SURFWET has been applied to simulate a specific case to demonstrate its robustness, in a 12-year-interval simulation. The results show the typical seasonality of this biotechnology, highlighting the importance of dissolved oxygen, which is a key limiting factor on a large number of biochemical processes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Published
2020
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48. Sarcopenia in Acute Care Patients: Protocol for the European Collaboration of Geriatric Surveys: Sarcopenia 9+ EAMA Project.

Author

Sanchez-Rodriguez D, Hope S, Piotrowicz K, Benoit F, Czesak J, Dallmeier D, Decker G, De Spiegeleer A, Højmann AH, Hrnciarikova D, Marco E, Mendes D, Meza D, Nascimento P, Rodrigues A, Surquin M, Toscano-Rico M, Vankova H, Vetrano DL, Gąsowski J, Van Den Noortgate N, and Landi F

Subjects
Aged, Aged, 80 and over, Body Composition, Female, Geriatric Assessment, Hand Strength, Humans, Male, Prevalence, Sarcopenia diagnosis, Walking, Ambulatory Care Facilities, Muscle, Skeletal physiopathology, Sarcopenia epidemiology
Published
2019
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49. Effects of flooding regime and meteorological variability on the removal efficiency of treatment wetlands under a Mediterranean climate.

Author

Sanchez-Ramos D, Aragones DG, and Florín M

Abstract

The modeling of free-water surface constructed wetlands (FWS-CWs) provides an improved understanding of their processes and constitutes a useful tool for the design and management of these systems. In this work, a dynamic simulation model for FWS-CWs was developed and used to simulate the operation of a FWS-CW proposed for improving the treatment of sewage effluents entering the Tablas de Daimiel National Park in central Spain. The process-based model simulates carbon, nitrogen and phosphorus dynamics, including key hydrological processes for wetlands under a fluctuating Mediterranean semiarid climate. The model allows for the simulation of the operation of FWS-CWs with variable flooding regimes, relating the surface water level to the flooded area and the water outflow. Simulations of the proposed FWS-CW under different water management schemes and scenarios were run, and the consequences of those management strategies on the treatment efficiency were analyzed. Under the Mediterranean climate and geology of the study area, namely, high water losses through evapotranspiration and infiltration, the decrease in nutrient concentrations was higher when the flooded area was reduced in summer than when a constant flooded area was maintained. Moreover, the meteorological variability introduced in different scenarios produced different results in terms of water outflow, but differences in terms of nutrient concentrations were not significant. The ability of the model to simulate different hydrological scenarios and their consequences on water quality makes it a useful decision-support tool., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
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50. High-resolution melt (HRM) analysis for detection of SNPs associated with pyrethroid resistance in the southern cattle fever tick, Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).

Author

Klafke GM, Miller RJ, Tidwell JP, Thomas DB, Sanchez D, Feria Arroyo TP, and Pérez de León AA

Subjects
Animals, Cattle, Cattle Diseases parasitology, Female, Genotype, Larva drug effects, Mutation, Real-Time Polymerase Chain Reaction, Transition Temperature, Insecticide Resistance genetics, Insecticides pharmacology, Polymorphism, Single Nucleotide, Pyrethrins pharmacology, Rhipicephalus genetics
Abstract

The southern cattle fever tick, Rhipicephalus (Boophilus) microplus, is the most economically important ectoparasite of cattle worldwide. A limitation for sustainable control and eradication is the emergence of acaricide resistance among tick populations. Molecular diagnostic tools offer the opportunity to detect resistance rapidly, which can be complemented with confirmatory bioassays with larvae and adult ticks that are more resource and time consuming to generate. Synthetic pyrethroid resistance is one of the most prevalent and well-studied forms of resistance in arthropods, being linked with target site alterations in the sodium ion channel gene. Here, we report research on a novel molecular method to detect mutations in the para-sodium channel gene of R. microplus associated with acaricide resistance that is based on quantitative PCR high-resolution melt (HRM) analysis. Genomic DNA fragments of domains II and III of the para-sodium channel gene were amplified by real-time PCR in the presence of EVA ® Green dye to test resistant and susceptible reference ticks from the U.S., Brazil, and Mexico. Larval packet tests with discriminating doses and a modified lethal time analysis were performed to confirm resistance to permethrin, cypermethrin, deltamethrin, and flumethrin in laboratory strains. Tick specimens collected from cattle that were inspected at the United States Port-of-Entry at the Texas-Mexico border were also genotyped. Previously described mutations associated with pyrethroid resistance (T170C, C190A, G184C, and T2134A) were successfully detected by qPCR-HRM in different genotypes and confirmed by sequencing. A novel non-synonymous SNP located at domain III (C2136A) and the G215T mutation in domain II, previously described only in Asian R. microplus and R. australis, were also detected with the HRM and confirmed by sequencing. This technique could be adapted for high-throughput screening, detection, and discovery of allele-specific mutations in cattle tick outbreak populations to inform eradication strategies in the USA. This knowledge could also be applied to integrated control programs in other parts of the world where R. microplus is endemic and where similar SNPs have been identified associated with pyrethroid resistance. This study highlights the existence of several mutations in the para-sodium channel gene in different combinations in field populations of R. microplus from Mexico., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2019
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