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In this work we report the electrochemical, spectroscopical and spectro-electrochemical studies of a model complex [Cu ΙΙ (Bztpen)] 2+ , (Bztpen = (N-benzyl-N,N',N'-tris(pyridin-2-ylmethyl)ethylenediamine) in order to propose a methodology to evaluate the interaction of potential metal based anticancer agents during electron transfer processes, with transport proteins such as Bovine Serum Albumin (BSA). It was possible to establish a reversible electron transfer [Cu ΙΙ (Bztpen)] 2+ +1e → [Cu Ι (Bztpen)] + and a weak interaction energy between BSA and [Cu ΙΙ (Bztpen)] and [Cu Ι (Bztpen)] species, with no adsorption of protein over the electrode surface. Circular Dichroism (CD) Spectroelectrochemistry, not reported before, reveals no significant changes in BSA structure during the electron transfer [Cu ΙΙ (Bztpen)] 2+ + 1e → [Cu Ι (Bztpen)] + . CD experiments at variable temperature for BSA denaturalization in the absence and in the presence of [Cu ΙΙ (Bztpen)] 2+ , shown no change in thermodynamic parameters due to low interaction between the transport protein and copper complex., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Inc. All rights reserved.)

In this work we report a series of Cu(II) complexes [Cu(N-N) 2 (X)] + , (N-N=substituted 1,10-phenanthroline derivatives and X=Cl - or NO 3 - ), with tunable E 1/2 for electrochemical reduction [Cu II (N-N) 2 (X)] + +1e - ⇌[Cu I (N-N) 2 ]+X - . The disproportion of O 2 •- was explored in presence of the electro-generated species [Cu I (N-N) 2 ] + using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E 1/2 ) for Cu(II)/Cu(I) couple shown a current increment for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species., (Copyright © 2017 Elsevier Inc. All rights reserved.)