32 results on '"Cordier, J."'
Search Results
2. Emerging Foodborne pathogens and the food industry
- Author
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Smoot, L., primary and Cordier, J.-L., additional
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- 2009
- Full Text
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3. INTERSTITIAL LUNG DISEASE | Cryptogenic Organizing Pneumonia
- Author
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Cordier, J.-F., primary
- Published
- 2006
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4. Enterobacteriaceae
- Author
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Cordier, J-L., primary
- Published
- 2006
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- View/download PDF
5. Industrial food microbiology and emerging foodborne pathogens
- Author
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Smoot, L., primary and Cordier, J-L., additional
- Published
- 2006
- Full Text
- View/download PDF
6. Inhibition of Astrocyte Gap Junctions by Endothelins
- Author
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Venance, L., primary, Siciliano, J.C., additional, Yokoyama, M., additional, Cordier, J., additional, Glowinski, J., additional, and Giaume, C., additional
- Published
- 1995
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7. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management
- Author
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Groh, M, Pagnoux, C, Baldini, C, Bel, E, Bottero, P, Cottin, V, Dalhoff, K, Dunogué, B, Gross, W, Holle, J, Humbert, M, Jayne, D, Jennette, J, Lazor, R, Mahr, A, Merkel, P, Mouthon, L, Sinico, R, Specks, U, Vaglio, A, Wechsler, M, Cordier, J, Guillevin, L, Guillevin, L., SINICO, RENATO ALBERTO, Groh, M, Pagnoux, C, Baldini, C, Bel, E, Bottero, P, Cottin, V, Dalhoff, K, Dunogué, B, Gross, W, Holle, J, Humbert, M, Jayne, D, Jennette, J, Lazor, R, Mahr, A, Merkel, P, Mouthon, L, Sinico, R, Specks, U, Vaglio, A, Wechsler, M, Cordier, J, Guillevin, L, Guillevin, L., and SINICO, RENATO ALBERTO
- Abstract
Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.
- Published
- 2015
8. Assessing the Impact of Stochasticity for Operating Theater Sizing
- Author
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Tancrez, J.-S., Roland, B., Cordier, J.-P., and Riane, F.
- Subjects
Healthcare management ,Markov process ,Emergencies ,Stochastic modeling ,Sizing ,Operating theater - Abstract
Over the last few decades, rational health care management and, in particular, operating theater planning, has attracted increased attention from practitioners and from the scientific community. However, although the operating theater environment is clearly stochastic, the impact of this randomness has often been ignored. In practice, simple rules based largely on past experience (such as keeping a safety margin), are most frequently used when making plans for the operating theater. In this paper, we propose an approach to help rationalize, at a strategic decision-making level, the way in which stochasticity can be taken into account in operating theater management, to help in the sizing and in the allocation of capacity. The three main sources of randomness are considered: durations of operations, unexpected emergencies and blocking because of a full recovery unit. Based on the Markov theory, our tool enables several performance measures to be estimated. An operating theater manager can use our approach to make informed decisions and assess, for example, the disruption of the planning by emergencies, the waiting times for emergency patients, the impact of the recovery unit, or the distribution of the working time. In particular, our approach helps determine the number of operations that should be planned in order to keep expected overtime limited. The tool is described in detail, discussed, and applied to the illustrative case of a Belgian hospital. (C) 2012 Elsevier B.V. All rights reserved.
9. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management
- Author
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David Jayne, Romain Lazor, Jean-François Cordier, Ulrich Specks, Marc Humbert, Klaus Dalhoff, Wolfgang L. Gross, Vincent Cottin, Peter A. Merkel, Matthieu Groh, Augusto Vaglio, Alfred Mahr, Paolo Bottero, Renato Alberto Sinico, Bertrand Dunogué, J. Charles Jennette, Loïc Guillevin, Christian Pagnoux, Michael E. Wechsler, Julia U Holle, Luc Mouthon, Chiara Baldini, Elisabeth H. Bel, Groh, M, Pagnoux, C, Baldini, C, Bel, E, Bottero, P, Cottin, V, Dalhoff, K, Dunogué, B, Gross, W, Holle, J, Humbert, M, Jayne, D, Jennette, J, Lazor, R, Mahr, A, Merkel, P, Mouthon, L, Sinico, R, Specks, U, Vaglio, A, Wechsler, M, Cordier, J, Guillevin, L, AII - Amsterdam institute for Infection and Immunity, and Pulmonology
- Subjects
United State ,medicine.medical_specialty ,Consensus ,Advisory Committees ,Churg-Strauss syndrome ,MEDLINE ,Consensu ,Recommendations ,Immunosuppressive Agent ,Glucocorticoid ,Eosinophilic ,Eosinophilia ,Internal Medicine ,Medicine ,Humans ,Churg–Strauss syndrome ,Disease management (health) ,Glucocorticoids ,Churg strauss ,Pulmonologists ,Advisory Committee ,business.industry ,Task force ,Eosinophilic granulomatosis with polyangiitis ,Medicine (all) ,Granulomatosis with Polyangiitis ,Disease Management ,Evidence-based medicine ,Recommendation ,medicine.disease ,United States ,Asthma ,Surgery ,Europe ,Anti-neutrophil cytoplasm antibody-associated vasculitis ,Anti-neutrophil cytoplasm antibody-associated vasculiti ,Family medicine ,Eosinophilic granulomatosis with polyangiiti ,Granulomatosis with Polyangiiti ,business ,Granulomatosis with polyangiitis ,Rituximab ,Churg-Strauss Syndrome ,Immunosuppressive Agents ,Human - Abstract
Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.
- Published
- 2015
10. Management of idiopathic pulmonary fibrosis in France: a survey of 1244 pulmonologists.
- Author
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Cottin V, Cadranel J, Crestani B, Dalphin JC, Delaval P, Israel-Biet D, Kessler R, Reynaud-Gaubert M, Valeyre D, Wallaert B, Bouquillon B, and Cordier JF
- Subjects
- Administration, Oral, Early Diagnosis, France, Health Care Surveys, Humans, Idiopathic Pulmonary Fibrosis physiopathology, Practice Guidelines as Topic, Pulmonary Diffusing Capacity, Surveys and Questionnaires, Treatment Outcome, Vital Capacity, Glucocorticoids therapeutic use, Idiopathic Pulmonary Fibrosis diagnosis, Idiopathic Pulmonary Fibrosis drug therapy, Pulmonary Medicine
- Abstract
Background: The present survey coordinated by the French expert centres for rare pulmonary diseases investigated French pulmonologists' current diagnostic and therapeutic practice for idiopathic pulmonary fibrosis (IPF)., Methods: From December 7, 2011 to February 18, 2012, all French pulmonologists (n = 2608) were contacted. Those who reported following up at least one IPF patient (n = 509) were administered a 26-item questionnaire by phone or e-mail., Results: 509 pulmonologists (41% of responders, 20% of French pulmonologists) were involved in the management of IPF patients. Of those, 36% discussed the cases with radiologists and pathologists. Out of 406 community pulmonologists practicing outside of reference or competence (e.g. expert) centres, 141 (35%) indicated referring patients to those centres. The 2011 international guidelines for IPF were known by 67% of pulmonologists involved in IPF, 84% of whom considered them appropriate for practice. About 58% of patients were diagnosed with mild to moderate IPF as defined by percentage predicted forced vital capacity ≥50% and percentage predicted diffusing capacity of the lung for carbon monoxide ≥35%. Management resulted from multidisciplinary discussion in 36% of the cases. By the end of December 2011, 49% of patients with mild to moderately severe IPF were treated with oral corticosteroids, and 27% received no treatment., Conclusions: Despite correct awareness of international IPF guidelines, modalities of multidisciplinary discussion and of early diagnosis and management need to be improved through the network of expert centres., (Copyright © 2013. Published by Elsevier Ltd.)
- Published
- 2014
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11. [Alveolar hemorrhage].
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Traclet J, Lazor R, Cordier JF, and Cottin V
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- Algorithms, Anti-Glomerular Basement Membrane Disease complications, Biopsy, Bronchoalveolar Lavage, Celiac Disease complications, Churg-Strauss Syndrome complications, Connective Tissue Diseases complications, Glucocorticoids therapeutic use, Graft Rejection, Granulomatosis with Polyangiitis complications, Hemorrhage diagnosis, Hemorrhage therapy, Humans, IgA Vasculitis complications, Leptospirosis complications, Lung pathology, Lung Diseases diagnosis, Lung Diseases therapy, Lung Transplantation adverse effects, Vasculitis complications, Hemorrhage etiology, Lung Diseases etiology, Pulmonary Alveoli
- Abstract
Diffuse alveolar hemorrhage (DAH) is defined by the presence of red blood cells originating from the lung capillaries or venules within the alveoli. The diagnosis is established on clinical features, radiological pattern, and especially bronchoalveolar lavage. Diffuse alveolar hemorrhage may have many immune or non-immune causes. Immune causes of DAH include vasculitides, connective tissue diseases, especially systemic lupus erythematosus, and antiglomerular basement membrane antibody disease (Goodpasture's syndrome). Treatment is both supportive and causal, often based on high dose corticosteroids and immunosuppressive therapy (especially intravenous cyclophosphamide). Plasma exchanges are performed in antiglomerular basement membrane antibody disease and systemic lupus erythematosus, and are considered in systemic vasculitis. Non-immune causes of DAH mainly include heart diseases, coagulation disorders, infections, drug toxicities and idiopathic DAH. Treatment of non-immune DAH is that of its cause. Whatever the cause, DAH is an emergency requiring prompt assessment and early treatment., (Copyright © 2012 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.)
- Published
- 2013
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12. [Intra-alveolar haemorrhage without renal damage as the initial presenting feature of Goodpasture's syndrome: case report and review of literature].
- Author
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Lê Quang C, Delèvaux I, Trouillier S, André M, Souweine B, Tridon A, Cordier JF, and Aumaître O
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- Adolescent, Adrenal Cortex Hormones administration & dosage, Adrenal Cortex Hormones therapeutic use, Adult, Biopsy, Bronchoalveolar Lavage, Cyclophosphamide administration & dosage, Cyclophosphamide therapeutic use, Drug Therapy, Combination, Female, Follow-Up Studies, Glomerular Basement Membrane immunology, Glomerular Basement Membrane pathology, Hemorrhage diagnosis, Humans, Immunosuppressive Agents administration & dosage, Immunosuppressive Agents therapeutic use, Lung Diseases diagnostic imaging, Male, Plasma Exchange, Prognosis, Radiography, Thoracic, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Anti-Glomerular Basement Membrane Disease diagnosis, Anti-Glomerular Basement Membrane Disease drug therapy, Anti-Glomerular Basement Membrane Disease immunology, Anti-Glomerular Basement Membrane Disease pathology, Anti-Glomerular Basement Membrane Disease therapy, Autoantibodies analysis, Hemorrhage etiology, Lung Diseases etiology, Pulmonary Alveoli
- Abstract
Isolated pulmonary involvement in Goodpasture's syndrome is exceptionally described. We report a 36-year-old woman with pulmonary haemorrhage and review 28 additional cases of the literature. In fact, these patients had often mild urine abnormalities and constant glomerular lesions. Antiglomerular basement membrane antibodies testing should be systematically ordered in patients presenting with alveolar haemorrhage. Goodpasture's syndrome without renal abnormality could be an early stage of the disease with a better prognosis.
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- 2008
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13. [Unusual pulmonary presentation of systemic Langerhans cell histiocytosis].
- Author
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Lega JC, Cottin V, Schuller A, Lazor R, Jullien D, and Cordier JF
- Subjects
- Aged, 80 and over, Biopsy, Humans, Lung pathology, Male, Bronchiectasis etiology, Histiocytosis, Langerhans-Cell diagnosis
- Abstract
An 80-year-old nonsmoking man was referred to our hospital with bilateral perihilar pulmonary opacities. He had a history of epilepsy, sclerosing cholangitis, cutaneous lesions previously diagnosed as localised Langerhans cell histiocytosis. Symptoms included dry cough and dyspnea. Chest CT showed bilateral perihilar alveolar consolidation with bronchiectasis. Histological examination of a lung biopsy showed typical features of Langerhans cell granulomatosis. Investigations revealed anterior and posterior hypopituitarism. An important improvement occurred with corticosteroid and vinblastine treatment.
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- 2008
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14. Mesenchymal cystic hamartoma of the lung in Cowden's disease.
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Cottin V, Thomas L, Loire R, Chalabreysse L, Gindre D, and Cordier JF
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- Female, Hamartoma Syndrome, Multiple pathology, Humans, Lung Neoplasms pathology, Middle Aged, Tomography, X-Ray Computed, Hamartoma Syndrome, Multiple diagnostic imaging, Lung Neoplasms diagnostic imaging
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- 2003
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15. [Pulmonary vasculitis].
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Cordier JF
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- Antibodies, Antineutrophil Cytoplasmic immunology, Biopsy, Churg-Strauss Syndrome diagnosis, Churg-Strauss Syndrome immunology, Granulomatosis with Polyangiitis diagnosis, Granulomatosis with Polyangiitis immunology, Humans, Lung Diseases diagnosis, Polyarteritis Nodosa diagnosis, Polyarteritis Nodosa immunology, Vasculitis diagnosis, Lung Diseases immunology, Vasculitis immunology
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- 2002
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16. [Primary sarcoma of the pulmonary artery. Case report].
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Gerard A, Durieu I, Cordier JF, Champsaur G, Loire R, and Vital Durand D
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- Angiography, Female, Humans, Middle Aged, Prognosis, Sarcoma diagnostic imaging, Sarcoma pathology, Vascular Neoplasms diagnostic imaging, Vascular Neoplasms pathology, Pulmonary Artery, Sarcoma diagnosis, Sarcoma surgery, Vascular Neoplasms diagnosis, Vascular Neoplasms surgery
- Abstract
Introduction: Sarcoma of the common pulmonary artery is a rare malignant tumor that can mimic pulmonary embolism., Exegesis: We report a case of a pulmonary artery sarcoma that occurred in a 60-year-old woman and had an unusual (4-year duration) evolution., Conclusion: Early diagnosis with adequate surgical procedures (complete resection) leads to better prognosis.
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- 1999
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17. Small-cell lung cancer: patients included in clinical trials are not representative of the patient population as a whole.
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Cottin V, Arpin D, Lasset C, Cordier JF, Brune J, Chauvin F, and Trillet-Lenoir V
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Small Cell pathology, Eligibility Determination, Female, Humans, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, Treatment Outcome, Carcinoma, Small Cell therapy, Clinical Trials as Topic methods, Lung Neoplasms therapy, Patient Selection
- Abstract
Purpose: To determine the clinical characteristics of the subpopulation of patients not included in clinical trials, their outcome, and the reasons for their ineligibility and non-participation., Patients and Methods: We studied 57 patients (out of 178 consecutive patients with SCLC), who were not included in any of the three successive clinical trials completed at our center during the study period. We also compared 37 patients excluded from the largest clinical trial to their 73 included counterparts., Results: Reasons for ineligibility (n = 53) included low Karnofsky index (n = 17), advanced age (n = 12), non-feasible long-term follow-up (n = 12), previous history of cancer (n = 8), contraindication for anthracyclines (n = 5), and other medical reasons (n = 11). Only four eligible patients were not included in the trials. As compared to patients included in the studies, non-included patients had a significantly lower Karnofsky index, were older, presented more frequently with metastatic disease, and had a lower response rate to treatment and a shorter survival. However, exclusion from the trial was not an independent prognostic factor by multivariate analysis., Conclusions: Selection biases were unlikely in the three trials, based on the high ratio of included/eligible patients. However, the subgroup of patients included in the trials was not representative of the patient population as a whole because of restrictive eligibility criteria. Results from published clinical trials to the overall population should be extrapolated only with caution. We suggest that the proportion and major characteristics of ineligible and non-participating patients be mentioned in any publication of a clinical trial.
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- 1999
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18. Differential effects of propofol and ketamine on cytosolic calcium concentrations of astrocytes in primary culture.
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Mantz J, Delumeau JC, Cordier J, and Petitet F
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- Animals, Astrocytes metabolism, Cells, Cultured, Cerebral Cortex embryology, Mice, Astrocytes drug effects, Calcium metabolism, Cytosol metabolism, Ketamine pharmacology, Propofol pharmacology
- Abstract
Propofol has been shown recently to alter cellular communication mediated by gap junctions between astrocytes (a glial cell subpopulation involved in major brain functions). As marked increases in concentrations of cytosolic calcium ([Ca2+]i) produce closure of the gap junction, we have investigated the effects of both propofol and ketamine on resting [Ca2+]i concentrations in mouse cultured astrocytes using microfluorimetry with the indo-1 fluorescent probe. Propofol 10(-5) and 10(-4) mol litre-1 induced a monophasic transitory Ca2+ peak in a large subpopulation of the cells tested. This response exhibited characteristics close to those of the peak elicited by [L-Pro9] substance P (10(-7) mol litre-1), an activator of phospholipase C in astrocytes. In both cases, it possibly corresponded to mobilization of Ca2+ from endogenous stores. In a few cases, however, administration of propofol induced a moderate, but sustained increase in [Ca2+]i corresponding to the entry of external Ca2+ into the cells. In contrast, ketamine 10(-5) and 10(-4) mol litre-1 failed to affect [Ca2+]i resting concentrations. These findings indicate that clinically relevant concentrations of propofol, but not ketamine, increased [Ca2+]i concentration in astrocytes.
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- 1994
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19. [Value of C-reactive protein determination in small cell lung cancer].
- Author
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Arpin D, Trillet-Lenoir V, Lasset C, Souquet PJ, Riou R, Yoanidis I, Guidollet J, Cordier JF, and Brune J
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Small Cell drug therapy, Dose-Response Relationship, Drug, Female, Humans, Lung Neoplasms drug therapy, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, C-Reactive Protein analysis, Carcinoma, Small Cell blood, Lung Neoplasms blood
- Abstract
A prospective analysis of serum levels of C-reactive protein (CRP) has been conducted on a series of 39 small cell lung cancer (SCLC) patients during the first course of chemotherapy in order to evaluate the predictive value of this marker on tumoral extension at diagnosis and response to therapy. Serum levels of CRP were measured before chemotherapy (day 0) and during the first two days of treatment (day 1, day 2). Twenty-three of 32 evaluable patients (71%) had extensive disease. The mean pre-treatment CRP level was significantly higher in this group than in the group of patients with limited disease (52.3 mg/l vs 15.8 mg/l, P = 0.02). Twenty-three patients responded to treatment and nine did not. The evolution of serum CRP levels in both groups was compared between day 0 and day 2. A more than two-fold increase of initial CRP levels showed a 100% predictive value for response. On the other hand, a decrease by more than 50% of initial serum levels was associated with a negative predictive value of 75% for response. We conclude that the follow-up of CRP levels during initial chemotherapy of SCLC might be useful in the initial evaluation of tumoral extension and in the early prediction of response to therapy.
- Published
- 1993
20. Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients.
- Author
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Cordier JF, Chailleux E, Lauque D, Reynaud-Gaubert M, Dietemann-Molard A, Dalphin JC, Blanc-Jouvan F, and Loire R
- Subjects
- Adult, Aged, Bronchoalveolar Lavage Fluid pathology, Bronchoscopy, Combined Modality Therapy, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Lung Neoplasms diagnostic imaging, Lung Neoplasms therapy, Lung Volume Measurements, Lymphoma, B-Cell pathology, Lymphoma, Large B-Cell, Diffuse pathology, Lymphoma, Non-Hodgkin diagnostic imaging, Lymphoma, Non-Hodgkin therapy, Male, Middle Aged, Retrospective Studies, Survival Rate, Tomography, X-Ray Computed, Lung Neoplasms pathology, Lymphoma, Non-Hodgkin pathology
- Abstract
We studied 70 patients with biopsy-proven pulmonary non-Hodgkin's lymphomas without extrathoracic involvement or mediastinal adenopathy to determine the clinical, imaging, and endoscopic features of this condition in a homogeneous series. In low-grade (LG) lymphomas, symptoms were cough, dyspnea, chest pain, hemoptysis. Imaging features consisted of localized alveolar opacities, infiltrative diffuse opacities, atelectasis, and pleural effusions. Inflammatory changes of the mucosa were present in some patients, leading to bronchial stenosis in 7; biopsies showed lymphomatous infiltration in 12. Prognosis of LG lymphomas was excellent, with 93.6 percent survival at five years. High-grade lymphomas differed from LG lymphomas principally by a more aggressive course and a worse survival. Inflammatory changes occurred in seven of nine cases leading to stenosis in two, and biopsies showed lymphomatous involvement in five. The profile of primary pulmonary lymphomas in this study could help clinicians consider this condition and prompt them to evaluate new diagnostic tools.
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- 1993
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21. Pretreatment staging evaluation in small cell lung carcinoma. A new approach to medical decision making.
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Chauvin F, Trillet V, Court-Fortune I, Velay B, Mazoyer G, Girodet B, Gormand F, Rebattu P, and Cordier JF
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Small Cell epidemiology, Carcinoma, Small Cell therapy, Combined Modality Therapy, Confidence Intervals, Decision Support Techniques, France epidemiology, Humans, Logistic Models, Lung Neoplasms epidemiology, Lung Neoplasms therapy, Methods, Neoplasm Staging, Prognosis, Radiotherapy Dosage, Retrospective Studies, Carcinoma, Small Cell pathology, Lung Neoplasms pathology
- Abstract
The real need for extensive staging at the time of diagnosis is discussed in regard to small cell lung carcinoma. We performed a decisional retrospective analysis on a series of 182 patients, based on three staging steps: the first step included physical examination and routine biologic tests. The second step consisted of liver ultrasonography and needle aspiration of any clinically detectable tumor mass, and the third step included bone marrow examination, radionuclide bone scan, thoracic, abdominal, and brain CT scan. A stepwise multivariate logistic regression performed on 11 variables considered in the first step shows that a four-parameter model can predict the spread of the disease (limited or extensive): weight loss, performance status, and elevated LDH or alkaline phosphatase levels. Limited disease can be predicted in two ways: (1) elevated LDH with normal alkaline phosphatases, no weight loss, and good performance status, or (2) normal LDH and alkaline phosphatases. In this series, 28 percent of patients can be predicted as having extensive disease and can be treated with chemotherapy alone without chest irradiation. After the second step, the probability of disease being extensive is only 25 percent, and only 84 (46.15 percent) patients would need to undergo the third step of staging procedures (brain CT scan, bone marrow aspiration and biopsy, radionuclide bone scan) with this method. We conclude that a multistep approach represents a simple staging method and offers the advantage of harmlessness and lower costs for patients not to be evaluated in prospective clinical trials.
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- 1992
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22. Thoracic splenosis presenting with hemoptysis.
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Cordier JF, Gamondes JP, Marx P, Heinen I, and Loire R
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- Chronic Disease, Hemoptysis etiology, Humans, Male, Middle Aged, Splenic Rupture complications, Thoracic Diseases complications, Thoracic Diseases etiology, Wounds, Gunshot complications, Hemoptysis diagnosis, Thoracic Diseases diagnosis
- Abstract
Thoracic splenosis (post-traumatic autotransplantation of splenic tissue) is rare and generally asymptomatic. We report a patient with thoracic splenosis presenting with repeated hemoptysis. The blood supply of the hypervascular splenic transplants originated from a bronchial and an intercostal artery. Hemoptysis improved after surgical exeresis of splenosis. Recognizing splenosis presenting with hemoptysis is important, since percutaneous embolotherapy could be hazardous because of the risk of ectopic splenic tissue infarction.
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- 1992
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23. Detection of an eosinophil derived neurotoxin in the urine of a patient with idiopathic chronic eosinophilic pneumonia.
- Author
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Deviller P, Gruart V, Prin L, Tardy F, Bulle C, Capron M, Capron A, and Cordier JF
- Subjects
- Chronic Disease, Electrophoresis, Agar Gel, Eosinophil-Derived Neurotoxin, Humans, Male, Middle Aged, Ribonucleases metabolism, Neurotoxins urine, Pulmonary Eosinophilia urine
- Published
- 1991
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24. [Treatment of diffuse interstitial pulmonary fibrosis].
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Cordier JF
- Subjects
- Fibroblasts physiology, Humans, Pulmonary Fibrosis physiopathology, Pulmonary Fibrosis therapy
- Abstract
At the stage of established pulmonary fibrosis there is no effective treatment. Hence the necessity of an early diagnosis at the "cellular" stage of diffuse interstitial fibrosing pneumopathy, which offers the best chances of improvement under corticosteroid therapy. Current biopathological researches on the dynamic mechanisms of fibrosis (fibrogenesis, fibrolysis) should open therapeutic lines involving cytokines and/or their receptors, including at the stage of gene transcription.
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- 1991
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25. Left pulmonary artery thrombosis in chlorpromazine-induced lupus.
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Roche-Bayard P, Rossi R, Mann JM, Cordier JF, and Delahaye JP
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- Adult, Female, Humans, Magnetic Resonance Imaging, Pulmonary Artery diagnostic imaging, Pulmonary Artery pathology, Pulmonary Embolism diagnosis, Pulmonary Embolism diagnostic imaging, Radiography, Chlorpromazine adverse effects, Lupus Erythematosus, Systemic chemically induced, Pulmonary Embolism chemically induced
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- 1990
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26. Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns.
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Peyrol S, Cordier JF, and Grimaud JA
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- Blood Coagulation Factors analysis, Collagen analysis, Fibrin analysis, Fibrinogen analysis, Fibronectins analysis, Humans, Immunohistochemistry, Pulmonary Alveoli ultrastructure, Bronchiolitis Obliterans pathology, Pneumonia pathology, Pulmonary Alveoli pathology, Pulmonary Fibrosis pathology
- Abstract
Idiopathic bronchiolitis obliterans-organizing pneumonia (BOOP) is characterized by air space fibrosis of unknown origin. Clinical resolution under steroid treatment suggests the removal of the fibrotic lesion. Open lung biopsies of four patients with idiopathic BOOP were studied by immunochemistry and electron microscopy. Three distinct cell-matrix patterns of intra-alveolar bud were found to represent the sequential evolution of the fibrotic process: fibrinoid inflammatory cell clusters in which immunoglobulins and procoagulant factors (fibrinogen, factors VII and X) were identified; fibroinflammatory buds in which desmin-containing fibroblasts were observed migrating, proliferating, and secreting matrix proteins; fibrotic buds in which myofibroblasts organized a loose connective matrix predominantly composed of fibronectin and type III collagen. Extending forms of fibrotic buds may join contiguous alveoli. Fibrotic bud remodeling ability is correlated to the nature and organization of the matrix components but the factors permitting intra-alveolar matrix degradation must be characterized.
- Published
- 1990
27. Pulmonary Wegener's granulomatosis. A clinical and imaging study of 77 cases.
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Cordier JF, Valeyre D, Guillevin L, Loire R, and Brechot JM
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- Adolescent, Adult, Aged, Biopsy, Bronchoalveolar Lavage Fluid, Bronchoscopy, Female, Granulomatosis with Polyangiitis diagnostic imaging, Granulomatosis with Polyangiitis pathology, Humans, Lung diagnostic imaging, Lung pathology, Lung Diseases diagnostic imaging, Lung Diseases pathology, Male, Middle Aged, Radiography, Granulomatosis with Polyangiitis diagnosis, Lung Diseases diagnosis
- Abstract
We studied 77 patients with biopsy-proven WG and pulmonary manifestations, to characterize the nature and frequency of the clinical, imaging and endoscopic features of this condition. Pulmonary symptoms were cough, mild dyspnea, hemoptysis and chest pain. Five patients had no pulmonary symptoms. Imaging features consisted of nodules, infiltrates and pleural opacities. A CT scan proved useful by disclosing cavities in opacities or opacities which were not seen on an x-ray film. Fiberoptic bronchoscopy was performed in 74 patients, and it was macroscopically abnormal in 55 percent (showing bronchial inflammation or stenosis or both or isolated hemorrhage). Six patients presented with alveolar hemorrhagic syndrome. Four patients had a pleural exudate rich in polymorphonuclear leukocytes. The WG was limited to the lung in seven patients. Sixteen patients died because of active disease or iatrogenic complications (two). An improved knowledge of clinical and imaging features of WG could help the clinician reach an earlier diagnosis.
- Published
- 1990
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28. [What is institutional psychotherapy? (author's transl)].
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Cordier JB
- Subjects
- Adolescent, Adolescent Psychiatry methods, Humans, Psychology, Adolescent, Institutional Practice, Psychotherapy methods
- Published
- 1980
29. Idiopathic bronchiolitis obliterans organizing pneumonia. Definition of characteristic clinical profiles in a series of 16 patients.
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Cordier JF, Loire R, and Brune J
- Subjects
- Adult, Aged, Bronchiolitis Obliterans classification, Bronchoalveolar Lavage Fluid cytology, Female, Humans, Lung diagnostic imaging, Male, Middle Aged, Pneumonia classification, Radiography, Respiratory Function Tests, Bronchiolitis Obliterans diagnosis, Lung pathology, Pneumonia diagnosis
- Abstract
Bronchiolitis obliterans organizing pneumonia (BOOP) is a pathologic finding common to various injuries to the lung of either definite or idiopathic etiology. Since the presentation of patients with idiopathic BOOP varies, we studied 16 patients with BOOP on pulmonary histology to define more distinct and homogeneous clinical and imaging profiles of idiopathic BOOP. We distinguished three groups of patients: group 1 (n = 4), with multiple patchy migratory pulmonary involvement of the pneumonia type. Their clinical course was subacute, with cough, fever, weight loss, mild dyspnea, and increased ESR. Chest x-ray film and CT scan showed multiple alveolar opacities. All patients completely recovered with corticosteroid therapy but relapsed when therapy was stopped too rapidly. Group 2 (n = 5) had solitary pulmonary involvement of the pneumonia type occurring in a similar clinical context. Since carcinoma was suspected, they underwent surgical excision of the pneumonic area and recovered without relapse. Group 3 patients (n = 7) presented with diffuse pulmonary involvement of the interstitial lung disease type. They had more progressive onset of more severe dyspnea, crackles heard over all lung surfaces, and interstitial opacities with or without alveolar opacities on chest imaging. Improvement with corticosteroid therapy was obtained in only three patients. In all three groups, lung function test results showed a restrictive pattern. The obstructive pattern characteristic of pure bronchiolitis obliterans was found in none. BAL showed a mixed pattern (increase of both lymphocytes and polymorphonuclear cells) in the patients of the first two groups. Thus, we distinguished three characteristic clinical and imaging profiles in patients with idiopathic BOOP: multiple patchy pneumonia, solitary pneumonia, and diffuse interstitial lung disease. These profiles are so different that they should be distinguished in clinical studies of idiopathic BOOP.
- Published
- 1989
- Full Text
- View/download PDF
30. Pulmonary sarcoidosis: flow cytometry measurement of lung T cell activation.
- Author
-
Mornex JF, Cordier G, Pages J, Lefebvre R, Revillard JP, Vergnon JM, Vincent M, Cordier JF, and Brune J
- Subjects
- Adult, Cell Cycle, Female, Fluorescent Antibody Technique, Humans, Lymphocyte Activation, Male, Middle Aged, Pulmonary Alveoli cytology, Lung Diseases immunology, Sarcoidosis immunology, T-Lymphocytes immunology
- Abstract
Lung T cell activation is considered a major factor in the pathogenesis of pulmonary sarcoidosis. Our study was designed to investigate several parameters of T cell activation among blood and alveolar cell populations, including expression of HLA-DR or MLR antigens, increased cell size, and presence of dividing cells. Blood sampling and bronchoalveolar lavages were performed in 20 patients with pulmonary sarcoidosis. Cell populations were analyzed by flow cytometry using immunofluorescence labeling with monoclonal antibodies to lymphocyte differentiation or activation antigens. Cell types were identified by their light-scattering properties. Cell cycle analysis was done after staining with acridine orange. Bronchoalveolar lavage contained a higher proportion of small T4-positive lymphocytes, and large cells of the same phenotype were detected in three patients. T cells bearing HLA-DR antigens were detected in six of 14 bronchoalveolar lavage samples. A marked increased of MLR-positive cells was found in the peripheral blood of eight of eight patients and in the bronchoalveolar lavage of five of seven patients. Increased percentages of cells in the S + G2 + M phases were found in blood lymphocytes from three patients and in half the bronchoalveolar lavage samples. Therefore, a variety of activation markers may be expressed by alveolar T cells. Their qualitative and quantitative assessment may provide additional criteria for staging the intensity of the alveolitis, and the possible relationship between these markers and disease progression or activity deserves long-term clinical investigation.
- Published
- 1985
31. Amyloidosis of the lower respiratory tract. Clinical and pathologic features in a series of 21 patients.
- Author
-
Cordier JF, Loire R, and Brune J
- Subjects
- Adult, Aged, Amyloid metabolism, Amyloidosis surgery, Birefringence, Bronchial Diseases pathology, Female, Humans, Lung Diseases surgery, Lung Neoplasms pathology, Male, Microscopy, Polarization, Middle Aged, Tissue Distribution, Tracheal Diseases pathology, Amyloidosis pathology, Lung Diseases pathology
- Abstract
Twenty one cases of amyloidosis of the lower respiratory tract were seen at a single center. In three patients, multifocal bronchial amyloid plaques led to stenosis and atelectasis, and in two, small pseudotumor masses were an incidental bronchoscopic finding. Two patients had nodular parenchymal amyloidosis, in one of whom the lesions were progressive and in the other static. Fifteen patients had diffuse parenchymal amyloidosis. Two of these had severe interstitial involvement and died in respiratory failure; eight had congestive cardiac failure, and parenchymal amyloidosis was a post-mortem finding; two had senile cardiorespiratory amyloidosis, also found at autopsy; and in three, the amyloidosis was associated with malignancy. The degree of respiratory embarrassment seemed to be related to the amount of amyloid in the gas diffusion zones, irrespective of the etiology of amyloidosis.
- Published
- 1986
- Full Text
- View/download PDF
32. Can new maths help disturbed children?
- Author
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Cordier J and Lowenthal F
- Subjects
- Child, Education, Special, Humans, Methods, Learning Disabilities, Mathematics, Teaching
- Published
- 1973
- Full Text
- View/download PDF
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