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4. Contributors

Author

Abdurakhmanov, Alexander, primary, Abu-Shakra, Mahmoud, additional, Afanasyeva, Marina, additional, Agmon-Levin, Nancy, additional, Albert, Paul J., additional, Almeida, Isabel, additional, Alves, Rute, additional, Amital, Howard, additional, Andrade, Paulo, additional, Antonelli, Alessandro, additional, Puccetti, Antonio, additional, Arango, María-Teresa, additional, Atzeni, Fabiola, additional, Baird, Alison E., additional, Balbir-Gurman, Alexandra, additional, Bashi, Tomer, additional, Batticciotto, Alberto, additional, Benucci, Maurizio, additional, Blank, Miri, additional, Bogdanos, Dimitrios P., additional, Bombardieri, S., additional, Borella, E., additional, Bosis, Samantha, additional, Bournia, Vasiliki Kalliopi, additional, Brandão, Mariana, additional, Braun-Moscovici, Yolanda, additional, Brender-Gotlieb, Neta, additional, Cainelli, Francesca, additional, Caldas, Cezar Augusto Muniz, additional, Campar, A., additional, Carvalheiras, Graziela, additional, Cervera, R., additional, Chapman, Joab, additional, Chastain, Emily M.L., additional, Claudio, Lunardi, additional, Cohen, Eytan, additional, Conti, Fabrizio, additional, Correia, J., additional, Carvalho, Jozélio Freire de, additional, Rossa, A. Della, additional, Detrick, Barbara, additional, Deutsch, Melanie, additional, Di Domenicantonio, Andrea, additional, Domeneghetti, M., additional, Domingues, Vital, additional, Doria, A., additional, Dow, Coad Thomas, additional, Dreyfus, David H., additional, Drouin, Elise E., additional, Dubaniewicz, Anna, additional, Durai, Malarvizhi, additional, Ebringer, Alan, additional, Ehrenfeld, Michael, additional, Elisa, Tinazzi, additional, Esposito, Susanna, additional, Fallahi, Poupak, additional, Faria, Raquel, additional, Farinha, Fátima, additional, Ferrannini, Ele, additional, Ferrari, Silvia Martina, additional, Ferreira, Alvaro, additional, Ferrão, C., additional, Garg, Ravindra Kumar, additional, Gatto, M., additional, Ghirardello, A., additional, Giovanna, Zanoni, additional, Giuseppe, Patuzzo, additional, Givaty, Gili, additional, Guilherme, Luiza, additional, Hammerstad, Sara Salehi, additional, Hodak, Emillia, additional, Hooks, John J., additional, Iaccarino, L., additional, Invernizzi, Pietro, additional, Israeli, Eitan, additional, Jamin, Christophe, additional, Janket, Sok-Ja, additional, Jarčuška, Peter, additional, Jones, Rodney P., additional, Kalil, Jorge, additional, Kanasi, Eleni, additional, Kivity, Shaye, additional, Konikoff, Tom, additional, Kozáková, D., additional, Krause, Ilan, additional, Lerner, Aaron, additional, Lidar, Merav, additional, Ling, Eduard, additional, Mahajna, Hussein, additional, Mahroum, Naim, additional, Maoz-Segal, Ramit, additional, Marinho, António, additional, Marshall, Trevor G., additional, Martinelli, Maria, additional, Marzia, Dolcino, additional, Mavragani, Clio P., additional, Mendonça, Teresa, additional, Miller, Stephen D., additional, Mimouni, Daniel, additional, Monteiro, Marta, additional, Moudgil, Kamal D., additional, Moulton, Vaishali R., additional, Moutsopoulos, Haralampos M., additional, Nagpal, Kamalpreet, additional, Neves, Esmeralda, additional, Nussenblatt, Robert, additional, Ollech, Ayelet, additional, Palma, L., additional, Pasoto, Sandra Gofinet, additional, Pella, Daniel, additional, Pereira, Cláudia, additional, Perricone, Carlo, additional, Petríková, Jana, additional, Proal, Amy D., additional, Rashid, Taha, additional, Reif, Shimon, additional, Renaudineau, Yves, additional, Ribeiro, Francinne Machado, additional, Rigante, Donato, additional, Rigopoulou, Eirini I., additional, Rose, Noel R., additional, Rosário, Cristina, additional, Rovenský, J., additional, Sakkas, Lazaros I., additional, Sarzi-Puttini, Piercarlo, additional, Seguro, Luciana Parente Costa, additional, Semino, Margherita, additional, Shoenfeld, Yehuda, additional, Silva, S., additional, Simonin, Laurent, additional, Smyk, Daniel S., additional, Sousa, Rita Catarina Medeiros, additional, Stagnaro, C., additional, Steere, Allen C., additional, Strle, Klemen, additional, Tektonidou, Maria G., additional, Tishler, Moshe, additional, Tomer, Yaron, additional, Toubi, Elias, additional, Tsokos, George C., additional, Vadasz, Zahava, additional, Valesini, Guido, additional, Vasconcelos, Carlos, additional, Vasconcelos, Júlia, additional, Vassilopoulos, Dimitrios, additional, Venkatesha, Shivaprasad H., additional, Vento, Sandro, additional, Viale, Christophe, additional, Villanueva, Ronald, additional, Vita, Pedro, additional, Wilson, Clyde, additional, Youinou, Pierre, additional, Záňová, E., additional, Zandman-Goddard, Gisele, additional, and Zen, M., additional

Published
2015
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5. Targeting eosinophils in allergic bronchopulmonary aspergillosis: is it effective as a steroid-sparing strategy?

Author

Senna Gianenrico, Claudio Micheletto, Giuliana Festi, Lucia Guidolin, Mattia Todesco, Marco Caminati, and Claudio Lunardi

Subjects
Pulmonary and Respiratory Medicine, lcsh:Immunologic diseases. Allergy, business.industry, Steroid sparing, Immunology, Immunology and Allergy, Medicine, Allergic bronchopulmonary aspergillosis, business, medicine.disease, lcsh:RC581-607
Published
2020

6. List of Contributors

Author

Jakub Abramson, S. Sohail Ahmed, Marco A. Alba, Youssif M. Ali, Julian L. Ambrus, Agnes Andersson Svärd, Martin Aringer, Shervin Assassi, Thanda Aung, Ilya Ayzenberg, Robert N. Barker, Alan G. Baxter, Corrado Betterle, Stanca A. Birlea, Niklas K. Björkström, Paul A. Blair, Stephan Blüml, Xavier Bosch, Robert A. Brodsky, Yenan T. Bryceson, Patrick R. Burkett, James B. Bussel, Roberto Caricchio, Livia Casciola-Rosen, Patrizio Caturegli, Benjamin Chaigne-Delalande, Paulina Chalan, Lucienne Chatenoud, Philip L. Cohen, Megan A. Cooper, Ken Coppieters, Ronald G. Crystal, Donna A. Culton, Valentina Damato, Anne Davidson, Lorenzo Delfino, Peter J. Delves, Giulia Di Dalmazi, Betty Diamond, Luis A. Diaz, Ronald J. Falk, Marvin J. Fritzler, Stefania Gallucci, Sapna Gangaputra, Brian Gelbman, M. Eric Gershwin, Igal Gery, Daniel R. Getts, Ralf Gold, Yael Goldfarb, Jing Gong, Siamon Gordon, Jörg J. Goronzy, Judith M. Greer, Vanesa A. Guazzone, Luiza Guilherme, David A. Hafler, Bevra H. Hahn, Abdel Rahim A. Hamad, Hideaki Hamano, Leonard C. Harrison, Dirk Homann, Eystein S. Husebye, J. Charles Jennette, Richard J. Jones, Margaret A. Jordan, Jorge Kalil, Shigeyuki Kawa, Ziya Kaya, Christian W. Keller, Nicholas J.C. King, Maleewan Kitcharoensakkul, Kendo Kiyosawa, Christoph Königs, Mitchell Kronenberg, Vijay K. Kuchroo, Arian Laurence, Eun-Ju Lee, Helmar C. Lehmann, Åke Lernmark, Ida Lindbladh, Zhi Liu, Hans-Gustaf Ljunggren, Claudio Lunardi, Knut E.A. Lundin, Jan D. Lünemann, Michael P.T. Lunn, Livia Lustig, Charles R. Mackay, Ian R. Mackay, Clara Malattia, Luisa Martinez-Pomares, Alberto Martini, Claudia Mauri, Pamela A. McCombe, Fritz Melchers, Giorgina Mieli-Vergani, Frederick W. Miller, Stephen D. Miller, Masayuki Mizui, Jenny Mjösberg, Christian Münz, Jagtar Singh Nijjar, David A. Norris, Kristine Oleinika, Joost J. Oppenheim, Mathias Pawlak, Cristina Peligero-Cruz, Anneli Peters, Pärt Peterson, Kalliopi Pitarokoili, Fabio Presotto, Antonio Puccetti, Hamid Rabb, Patricia Raczek, M. Jubayer Rahman, Manuel Ramos-Casals, Noel R. Rose, Antony Rosen, Mohanraj Sadasivam, Adam Schiffenbauer, Wilhelm J. Schwaeble, H. Nida Sen, Marc Serota, Kazim A. Sheikh, Yehuda Shoenfeld, Ora Shovman, Joachim Sieper, Arthur M. Silverstein, Robert B. Sim, Kenneth G C Smith, Josef S. Smolen, Ludvig M. Sollid, Alanna Spiteri, Lawrence Steinman, John H. Stone, Uta Syrbe, Ami Tamhaney, Atsushi Tanaka, Veena Taneja, Kristin V. Tarbell, Elisa Tinazzi, Benedict K. Tiong, Ban-Hock Toh, George C. Tsokos, Kenneth S.K. Tung, John Varga, Diego Vergani, Mark A. Vickers, Stuart Viegas, Angela Vincent, Matthias von Herrath, Anthony P. Weetman, Joel V. Weinstock, John M. Wentworth, Sarah Wesley, Cornelia M. Weyand, Gerhard Wingender, Michael W. Winter, Renato Zanchetta, and Moncef Zouali

Published
2020

8. Autoantigens and Autoantibodies in the Pathogenesis of Sjögren’s Syndrome

Author

Giuseppe Patuzzo, Elisa Tinazzi, and Claudio Lunardi

Subjects
Pathogenesis, stomatognathic diseases, biology, Antigen, Carbonic anhydrase II, Immunology, biology.protein, Autoantibody, Disease, Lipocalin, Sjogren s, Calreticulin
Abstract

A fundamental aspect in the comprehension of the mechanisms responsible for the pathogenesis of Sjogren’s syndrome (SS) is the identification of the antigenic determinants that play a pivotal role in triggering and maintaining the disease. Moreover, the identification of autoantigens may lead to the definition of autoantibodies that either contribute to the onset of the disease or can be useful for diagnosis. The most well-defined autoantigens in SS are some intracellular antigens, such as Ro52/TRIM21, Ro60/TROVE2, and La/SSB, which are all part of ribonucleoproteins-RNA complexes. Other autoantibody targets are represented by mitochondrial antigens, muscarinic receptors, carbonic anhydrase II, smooth muscle antigens, α-fodrin, and lipocalin. Recently, studies in animal models have identified novel antigens, which have been tested by the Sjogren's International Collaborative Clinical Alliance (SICCA) to verify their reliability in humans. Herein, we describe some of these autoantigens and their possible role in the pathogenesis of the disease.

Published
2016

9. List of Contributors

Author

Nancy Agmon-Levin, S. Sohail Ahmed, Youssif M. Ali, Martin Aringer, Jean-François Bach, Jennifer Barker, Robert N. Barker, Alan G. Baxter, Corrado Betterle, Stanca A. Birlea, Niklas K. Björkström, Paul A. Blair, Alex Bobik, Nabeel H. Borazan, Xavier Bosch, Robert A. Brodsky, Yenan T. Bryceson, Patrick R. Burkett, James B. Bussel, Helmut Butzkueven, Roberto Caricchio, Livia Casciola-Rosen, Patrizio Caturegli, Lucienne Chatenoud, Philip L. Cohen, Ken Coppieters, Sarah Q. Crome, Ronald G. Crystal, Donna A. Culton, Monica D. Dalal, Chella S. David, Anne Davidson, Ahmed J. Delli, Peter J. Delves, Vera Kandror Denmark, Betty Diamond, Luis A. Diaz, John E. Eaton, George S. Eisenbarth, Ronald J. Falk, Judith Field, Thomas A. Fleisher, George E. Fragoulis, Marvin J. Fritzler, Daniel E. Furst, Stefania Gallucci, Brian Gelbman, M. Eric Gershwin, Daniel R. Getts, Meghann Teague Getts, Roberto Gianani, Paul A. Gleeson, James W. Goding, Siamon Gordon, Jörg J. Goronzy, Judith M. Greer, Berengere Gruson, L. Guilherme, Angelika Gutenberg, David A. Hafler, Bevra H. Hahn, Hideaki Hamano, Sara R. Hamilton, Leonard C. Harrison, Amanda L. Hernandez, Eystein Husebye, J. Charles Jennette, Richard J. Jones, Margaret A. Jordan, J. Kalil, Christoph Königs, Shigeyuki Kawa, Ziya Kaya, Jennifer K. King, Nicholas J.C. King, Kendo Kiyosawa, Mitchell Kronenberg, Vijay K. Kuchroo, Tin Kyaw, Jan Lünemann, Robert G. Lahita, Parviz Lalezari, Paul-Henri Lambert, Eric Lancaster, Arian Laurence, Youjin Lee, Michael Lenardo, Åke Lernmark, Arnold I. Levinson, Keith D. Lindor, Zhi Liu, Hans-Gustaf Ljunggren, Claudio Lunardi, Knut E.A. Lundin, Michael P.T. Lunn, Isabella Lupi, Livia Lustig, Christian Münz, Charles R. Mackay, Ian R. Mackay, Clara Malattia, Ashutosh Mangalam, Alberto Martini, Claudia Mauri, Clio P. Mavragani, Lloyd Mayer, Pamela A. McCombe, Fritz Melchers, Giorgina Mieli-Vergani, Frederick W. Miller, Stephen D. Miller, Masayuki Mizui, Jenny Mjösberg, Haralampos M. Moutsopoulos, David A. Norris, Robert B. Nussenblatt, Kevin C. O’Connor, Pamela S. Ohashi, Meredith O’Keeffe, Joao Bosco Oliveira, Joost J. Oppenheim, Alicia Perez-Arroyo, Anneli Peters, Pärt Peterson, Annette Plüddemann, Jerome B. Posner, Gloria A. Preston, Antonio Puccetti, Kristen Radford, Manuel Ramos-Casals, V. Koneti Rao, Paula K. Rauschkolb, Venkat Reddy, Kurt Redlich, Claudia Rival, Noel R. Rose, Antony Rosen, John W. Schrader, Wilhelm J. Schwaeble, Carlo Selmi, H. Nida Sen, Marc Serota, Kazim A. Sheikh, Yehuda Shoenfeld, Ken Shortman, Joachim Sieper, Arthur M. Silverstein, Robert B. Sim, Anna Simon, Josef S. Smolen, Ludvig M. Sollid, Monique Stoffels, Helen Su, Uta Syrbe, Jayant A. Talwalkar, Veena Taneja, Angela Tincani, Peter Tipping, Ban-Hock Toh, George C. Tsokos, Eric Tu, Kenneth S.K. Tung, Ian R. van Driel, Diego Vergani, Mark A. Vickers, Stuart Viegas, Angela Vincent, Ulrich H. von Andrian, Matthias von Herrath, Anthony P. Weetman, John M. Wentworth, Cornelia M. Weyand, Gerhard Wingender, Renato Zanchetta, and Moncef Zouali

Published
2014

10. Immune-Mediated Inner Ear Disease

Author

Antonio Puccetti and Claudio Lunardi

Subjects
Autoimmune disease, Pathology, medicine.medical_specialty, business.industry, Cogan syndrome, anticochlea antibodies, Autoimmune inner ear disease, Disease, medicine.disease, Pathophysiology, medicine.anatomical_structure, Immune system, anti-CD148 peptide, inner ear disease, Immunology, otorhinolaryngologic diseases, medicine, Inner ear, Sensorineural hearing loss, sense organs, cogan syndrome, business
Abstract

Inner ear damage can be caused by viral infections, trauma, vascular damage, and immune mechanisms, and is responsible for sensorineural hearing loss, a syndrome characterized by rapid progression of hearing impairment that is frequently non-responsive to medical treatment. Immune-mediated inner ear disease can be of autoimmune origin either as an isolated process affecting only the ear, to be considered as an organ-specific autoimmune disease, or as part of a systemic autoimmune disorder in approximately 30% of cases. The incidence and prevalence of autoimmune inner ear disease is unknown due to the lack of reliable diagnostic tests and to the limited access to the site of autoimmune aggression. Since the rapid administration of steroids and/or other immunosuppressive agents may result in hearing preservation, a great effort is needed in order to find both clinical and immunological features able to identify these patients. Animal models of autoimmune inner ear disease may help in this effort to clarify the largely unknown pathophysiology of the disease and the response to therapy.

Published
2014

11. Inner Ear Disease

Author

Claudio Lunardi and Antonio Puccetti

Subjects
Pathology, medicine.medical_specialty, antiCD148 antibodies, sensorineural hearing loss, immune mediated inner ear disease, business.industry, Diagnostic test, Disease, medicine.disease_cause, medicine.disease, Autoimmunity, medicine.anatomical_structure, Immune system, Inner ear disease, Antigen, Immunology, otorhinolaryngologic diseases, medicine, Inner ear, Sensorineural hearing loss, sense organs, business
Abstract

Publisher Summary It is now evident that the inner ear is not an “immunologically privileged” site and may mount an immune response against both foreign and self-antigens. This chapter focuses on sensorineural hearing loss (SNHL). This has been described and termed in different ways: autoimmune SNHL, immunemediated inner ear disease (IMIED), idiopathic progressive bilateral SNHL, sudden SNHL, and idiopathic SNHL, bilateral immune-mediated Meniere's disease, autoimmune vestibulo-cochlear disorders, generating a great confusion in the identification of patients and in the evaluation of different studies. The association of IMIED with systemic autoimmune diseases provides evidence that autoimmunity can damage the inner ear, but it does not address organ-specific disease. Antibodies directed against different inner ear antigens have been identified in some patients. However, they are neither diagnostic nor correlate with disease state. In the future, the major goals for research in this field can be the identification of pathogenetically relevant autoantigens, development of a highly specific diagnostic test, and a better knowledge of the immunopathologic mechanisms in an organ as inaccessible as the inner ear.

Published
2006

12. Contributors

Author

Frank Alderuccio, Elaine L. Alexander, Gunnar V. Alm, Irina Apostolou, Elizabeth G. Araujo, Jean-François Bach, Jennifer M. Barker, Anthony Basten, Kenneth L. Baughman, David Bernhard, Corrado Betterle, Carol M. Black, Steven Brass, Robert Brink, Robert A. Brodsky, Camilla Buckley, Gerd-Rüdiger Burmester, Livia Casciola-Rosen, Patrizio Caturegli, Lucienne Chatenoud, Marcus R. Clark, Ross L. Coppel, Joe Craft, Ronald G. Crystal, Albert J. Czaja, Chella S. David, Anne Davidson, Peter J. Delves, Christopher P. Denton, Betty Diamond, Luis A. Diaz, Thomas Dörner, George S. Eisenbarth, Paul Emery, Lorenzo Emmi, Andrew G. Engel, Ronald J. Falk, Martin J. Fritzler, Brian Gelbman, M. Eric Gershwin, Bruce C. Gilliland, Bruno Giometto, James W. Goding, Tom P. Gordon, Jörg J. Goronzy, David Green, Matthew A. Gronski, Luiza Guilherme, David A. Hafler, Hideaki Hamano, Reinhard Hohlfeld, Katherine Morland Hammitt, Leonard C. Harrison, Blair Henderson, Hans Hengartner, Matthias von Herrath, Julio Hilario-Vargas, Michael W. Jackson, J. Charles Jennette, Richard Jones, Jorge E. Kalil, Olle Kämpe, Insoo Kang, Simon Karpatkin, Shigeyuki Kawa, Kendo Kiyosawa, Michael Knoflach, Karsten Kretschmer, Leila I. Kump, Parviz Lalezari, Robert G. Lahita, Grace A. Levy-Clarke, Ning Li, Zhuqing Li, Judith L. Luborsky, Zhi Liu, Claudio Lunardi, Knut E.A. Lundin, Michael P.T. Lunn, Livia Lustig, Charles R. Mackay, Fabienne Mackay, Ian R. Mackay, Sarah Mackie, Michael G. McHeyzer-Williams, Kevin J. Maloy, Menelaos N. Manoussakis, Michael P. Manns, Emanual Maverakis, Lloyd F. Mayer, Agnes Mayr, Ian G. McFarlane, Giorgina Mieli-Vergani, Frederick W. Miller, Øyvind Molberg, Muriel Moser, Kamal D. Moudgil, Haralambos M. Moutsopoulos, Gerald T. Nepom, Robert B. Nussenblatt, Pamela S. Ohashi, Ron Palmon, Pärt Peterson, Michelle Petri, Fiona Powrie, Barrak M. Pressler, Gloria A. Preston, Antonio Puccetti, Mark Quinn, Simon Read, Bart O. Roep, Sergio Romagnami, Lars Rönnblom, Noel R. Rose, Antony Rosen, Robert A.S. Roubey, Jean-Marie R. Saint-Remy, Pere Santamaria, Carlo Selmi, Eli E. Sercarz, Kazim A. Sheikh, Yehuda Shoenfeld, Joachim Sieper, Arthur M. Silverstein, Ludvig M. Sollid, Wolfram Sterry, Veena Taneja, Stuart Tangye, Moshe Tishler, Yaron Tomer, Ban-Hock Toh, George C. Tsokos, Kenneth S.K. Tung, Shey-Cherng Tzou, Raivo Uibo, David L. Vaux, Diego Vergani, Marika Vianello, Angela Vincent, Roberta Vitaliani, Ulrich H. Von Andrian, Harald Von Boehmer, Mindi R. Walker, Sally A. Waterman, Howard L. Weiner, Cornelia M. Weyand, Anthony P. Weetman, Senga Whittingham, Georg Wick, Allan Wiik, Margitta Worm, Yang Yang, Renato Zanchetta, and Rolf M. Zinkernagel

Published
2006

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