1. Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis.
- Author
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Pourgholami MH, Khachigian LM, Fahmy RG, Badar S, Wang L, Chu SW, and Morris DL
- Subjects
- Animals, Cells, Cultured, Disease Models, Animal, Endothelium, Vascular cytology, Endothelium, Vascular physiology, Humans, Infant, Newborn, Mice, Umbilical Veins cytology, Vascular Endothelial Growth Factor Receptor-2 biosynthesis, Albendazole pharmacology, Angiogenesis Inhibitors pharmacology, Capillary Permeability drug effects, Cell Movement drug effects, Endothelium, Vascular drug effects, Retinal Neovascularization physiopathology, Retinopathy of Prematurity physiopathology, Vascular Endothelial Growth Factor Receptor-2 antagonists & inhibitors
- Abstract
The angiogenic process begins with the cell proliferation and migration into the primary vascular network, and leads to vascularization of previously avascular tissues and organs as well to growth and remodeling of the initially homogeneous capillary plexus to form a new microcirculation. Additionally, an increase in microvascular permeability is a crucial step in angiogenesis. Vascular endothelial growth factor (VEGF) plays a central role in angiogenesis. We have previously reported that albendazole suppresses VEGF levels and inhibits malignant ascites formation, suggesting a possible effect on angiogenesis. This study was therefore designed to investigate the antiangiogenic effect of albendazole in non-cancerous models of angiogenesis. In vitro, treatment of human umbilical vein endothelial cells (HUVECs) with albendazole led to inhibition of tube formation, migration, permeability and down-regulation of the VEGF type 2 receptor (VEGFR-2). In vivo albendazole profoundly inhibited hyperoxia-induced retinal angiogenesis in mice. These results provide new insights into the antiangiogenic effects of albendazole., (Copyright 2010 Elsevier Inc. All rights reserved.)
- Published
- 2010
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