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1. Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trialResearch in context

Author

Carolina Herrera, Jennifer Serwanga, Laura Else, Lebina Limakatso, Daniel Opoka, Andrew S. Ssemata, Azure-Dee Pillay, Patricia Namubiru, Thabiso B. Seiphetlo, Geoffrey Odoch, Susan Mugaba, Portia Seatlholo, Amara Alieu, Sujan Dilly Penchala, Richard Muhumuza, Berenice Alinde, Stefan Petkov, Kyle O'Hagan, Christian Callebaut, Janet Seeley, Helen Weiss, Saye Khoo, Francesca Chiodi, Clive M. Gray, Pontiano Kaleebu, Emily L. Webb, Neil Martinson, Julie Fox, Nadia Ahmed, Millicent Atujuna, Esther Awino, Linda-Gail Bekker, Mike Chirenje, Janan Dietrich, Jeffrey Dorfman, Clive Gray, Christian Holm Hansen, Stefanie Hornschuh, Ayoub Kakande, Charles Kelly, Mamkiri Khunwane, Limaktso Lebina, Joseph Makhura, Nomvuyo Mangxilana, Freddie Mukasa Kibengo, Gertrude Mutonyi, Lucia Mungate, Winnie Nabukeera, Rehema Nagawa, Phiona Nalubega, Stephen Nash, Denis Ndekezi, Teacler Nematadzira, Lumka Nobula, Jim Rooney, Elzette Rousseau, Eugene Ruzagira, Alison Sango, Ntombexolo Seatlholo, Thabiso Seiphetlo, Robin Shattock, Lynda Stranix-Chibanda, Gugulethu Tshabalala, and Emily Webb

Subjects
HIV-1, Foreskin, Oral PrEP, Adolescents, PK/PD, Tissue explants, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: The efficacy of on-demand HIV pre-exposure prophylaxis (PrEP) for men in sub-Saharan Africa has not been evaluated, and the on-demand PrEP dosing requirement for insertive sex remains unknown. Methods: HIV-negative males 13–24 years, requesting voluntary medical male circumcision (VMMC), were enrolled into an open-label randomised controlled trial (NCT03986970), and randomised 1:1:1:1:1:1:1:1:1 to control arm or one of eight arms receiving emtricitabine-tenofovir disoproxil fumarate (F/TDF) or emtricitabine-tenofovir alafenamide (F/TAF) over one or two days, and circumcised 5 or 21 h thereafter. The primary outcome was foreskin p24 concentrations following ex vivo HIV-1BaL challenge. Secondary outcomes included peripheral blood mononuclear cell (PBMC) p24 concentration, and drug concentrations in foreskin tissue, PBMCs, plasma and foreskin CD4+/CD4-cells. In the control arm, post-exposure prophylaxis (PEP) activity of non-formulated tenofovir-emtricitabine (TFV-FTC) or TAF-FTC was assessed with ex vivo dosing 1, 24, 48 or 72 h post-HIV-1 challenge. Findings: 144 participants were analysed. PrEP with F/TDF or F/TAF prevented ex vivo infection of foreskins and PBMCs both 5 and 21 h after PrEP dosing. There was no difference between F/TDF and F/TAF (p24day15 geometric mean ratio 1.06, 95% confidence interval: 0.65–1.74). Additional ex vivo dosing did not further increase inhibition. In the control arm, PEP ex vivo dosing was effective up to 48 post-exposure diminishing thereafter, with TAF-FTC showing prolonged protection compared to TFV-FTC. Participants receiving F/TAF had higher TFV-DP concentrations in foreskin tissue and PBMCs compared with F/TDF, irrespective of dose and sampling interval; but F/TAF did not confer preferential TFV-DP distribution into foreskin HIV target cells. FTC-TP concentrations with both drug regimens were equivalent and ∼1 log higher than TFV-DP in foreskin. Interpretation: A double dose of either F/TDF or F/TAF given once either 5 or 21 h before ex vivo HIV-challenge provided protection across foreskin tissue. Further clinical evaluation of pre-coital PrEP for insertive sex is warranted. Funding: EDCTP2, Gilead Sciences, Vetenskapsrådet.

Published
2023
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2. Observed protection against SARS-CoV-2 reinfection following a primary infection: A Danish cohort study among unvaccinated using two years of nationwide PCR-test data

Author

Daniela Michlmayr, Christian Holm Hansen, Sophie Madeleine Gubbels, Palle Valentiner-Branth, Peter Bager, Niels Obel, Birgitte Drewes, Camilla Holten Møller, Frederik Trier Møller, Rebecca Legarth, Kåre Mølbak, and Steen Ethelberg

Subjects
COVID-19, Cohort studies, Immunity, Reinfection, Herd immunity, SARS-CoV-2 variants, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: The level of protection after a SARS-CoV-2 infection against reinfection and COVID-19 disease remains important with much of the world still unvaccinated. Methods: Analysing nationwide, individually referable, Danish register data including RT-PCR-test results, we conducted a cohort study using Cox regression to compare SARS-CoV-2 infection rates before and after a primary infection among still unvaccinated individuals, adjusting for sex, age, comorbidity and residency region. Estimates of protection against infection were calculated as 1 minus the hazard ratio. Estimates of protection against symptomatic infections and infections leading to hospitalisation were also calculated. The prevalence of infections classified as symptomatic or asymptomatic was compared for primary infections and reinfections. The study also assessed protection against each of the main viral variants after a primary infection with an earlier variant by restricting follow-up time to distinct, mutually exclusive periods during which each variant dominated. Findings: Until 1 July 2021 the estimated protection against reinfection was 83.4% (95%CI: 82.2–84.6%); but lower for the 65+ year-olds (72.2%; 95%CI: 53.2–81.0%). Moderately higher estimates were found for protection against symptomatic disease, 88.3% overall (95%CI: 85.9–90.3%). First-time cases who reported no symptoms were more likely to experience a reinfection (odds ratio: 1.48; 95%CI: 1.35–1.62). By autumn 2021, when infections were almost exclusively caused by the Delta variant, the estimated protection following a recent first infection was 91.3% (95%CI: 89.7–92.7%) compared to 71.4% (95%CI: 66.9–75.3%) after a first infection over a year earlier. With Omicron, a first infection with an earlier variant in the past 3-6 months gave an estimated 51.0% (95%CI: 50.1–52.0%) protection, whereas a first infection longer than 12 months earlier provided only 19.0% (95%CI: 17.2–20.5%) protection. Protection by an earlier variant-infection against hospitalisation due to a new infection was estimated at: 86.6% (95%CI: 46.3–96.7%) for Alpha, 97.2% (95%CI: 89.0–99.3%) for Delta, and 69.8% (95%CI: 51.5–81.2%) for the Omicron variant. Interpretation: SARS-CoV-2 infection offered a high level of sustained protection against reinfection, comparable with that offered by vaccines, but decreased with the introduction of new main virus variants; dramatically so when Omicron appeared. Protection was lower among the elderly but appeared more pronounced following symptomatic compared to asymptomatic infections. The level of estimated protection against serious disease was somewhat higher than that against infection and possibly longer lasting. Decreases in protection against reinfection, seemed primarily to be driven by viral evolution. Funding: None.

Published
2022
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3. Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

Author

Pamela Warner, Lucy Harriet Ravenscroft Whitaker, Richard Anthony Parker, Christopher John Weir, Anne Douglas, Christian Holm Hansen, Mayank Madhra, Stephen Gilbert Hillier, Philippa Tansy Kemp Saunders, John Peter Iredale, Scott Semple, Ov Daniel Slayden, Brian Robert Walker, and Hilary Octavia Dawn Critchley

Subjects
Heavy menstrual bleeding (HMB), Randomised controlled trial, Dexamethasone, Adaptive randomisation, Endometrium, Bayesian, Medicine, Medicine (General), R5-920
Abstract

Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due to endometrial glucocorticoid deficiency. Does reversing this deficiency, by short-term luteal-phase treatment with exogenous glucocorticoid (dexamethasone), ameliorate HMB? Methods: In our Bayesian response-adaptive parallel-group placebo-controlled randomised trial, five pre-planned interim analyses used primary outcome data to adjust randomisation probabilities to favour doses providing most dose-response information. Participants with HMB, recruited from Lothian (Scotland) NHS clinics and via community invitations/advertisements, were aged over 18 years; reported regular 21–42 day menstrual cycles; and had measured menstrual blood loss (MBL) averaging ≥ 50 mL over two screening periods. Identically encapsulated placebo, or one of six Dexamethasone doses (0·2 mg, 0·4 mg, 0·5 mg, 0·6 mg, 0·75 mg, 0·9 mg), were taken orally twice-daily over five days in the mid-luteal phase of three menstrual cycles. Participants, investigators, and those measuring outcomes were masked to group assignment.Primary outcome, change in average MBL from screening to ‘treatment’, was analysed by allocated treatment, for all with data. Trial Registration: ClinicalTrials.gov NCT01769820; EudractCT 2012–003,405–98 Findings: Recruitment lasted 29/01/2014 to 25/09/2017; 176 were screened, 107 randomised and 97 provided primary outcome data (n = 24,5,9,21,8,14,16 in the seven arms, placebo to 1·8 mg total daily active dose). In Bayesian normal dynamic linear modelling, 1·8 mg dexamethasone daily showed a 25 mL greater reduction in MBL from screening, than placebo (95% credible interval 1 to 49 mL), and probability 0·98 of benefit over placebo. Adverse events were reported by 75% (58/77) receiving dexamethasone, 58% (15/26) taking placebo. Three serious adverse events occurred, two during screening, one in a placebo participant. No woman withdrew due to adverse effects. Interpretation: Our adaptive trial in HMB showed that dexamethasone 1·8 mg daily reduced menstrual blood loss. The role of dexamethasone in HMB management deserves further investigation. Funding: UK MRC DCS/DPFS grant MR/J003611/1.

Published
2021
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4. A social empowerment intervention to prevent intimate partner violence against women in a microfinance scheme in Tanzania: findings from the MAISHA cluster randomised controlled trial

Author

Saidi Kapiga, ProfMD, Sheila Harvey, PhD, Gerry Mshana, PhD, Christian Holm Hansen, PhD, Grace J Mtolela, Flora Madaha, BA, Ramadhan Hashim, PGD, Imma Kapinga, BA, Neema Mosha, MSc, Tanya Abramsky, MSc, Shelley Lees, PhD, and Charlotte Watts, ProfPhD

Subjects
Public aspects of medicine, RA1-1270
Abstract

Summary: Background: Globally, about 30% of women have experienced physical or sexual violence, or both, from an intimate partner during their lifetime. Associations between poverty and women's increased risk of intimate partner violence have been observed. We therefore aimed to assess the effect of a violence prevention intervention delivered to women participating in a group-based microfinance scheme in Tanzania. Methods: We did a cluster randomised controlled trial among women taking part in a microfinance loan scheme in Mwanza city, Tanzania. A microfinance loan group was only enrolled if at least 70% of members consented. We randomly assigned the microfinance groups in blocks of six to receive either the intervention (ie, the intervention arm) or be wait-listed for the intervention after the trial (ie, the control arm). Women in both arms of the trial met weekly for loan repayments. Only those in the intervention arm participated in the ten-session MAISHA intervention that aims to empower women and prevent intimate partner violence. Given the nature of the intervention, it was not possible to mask participants or the research team. The primary outcome was a composite of reported past-year physical or sexual intimate partner violence, or both. Secondary outcome measures were past-year physical, sexual, and emotional intimate partner violence; acceptability and tolerance of intimate partner violence; and attitudes and beliefs related to intimate partner violence. These outcomes were assessed 24 months after the intervention. An intention-to-treat analysis was done, adjusting for age, education, and baseline measure of the respective outcome. The study is registered with ClinicalTrials.gov, number NCT02592252. Findings: Between September, 2014, and June, 2015, 66 (65%) of 101 microfinance groups approached in the study area met the trial eligibility criteria and were enrolled, of which 33 (n=544 women) were allocated to the intervention arm and 33 (n=505 women) to the control arm. Overall, 485 (89%) of 544 women in the intervention arm and 434 (86%) of 505 in the control arm completed the outcomes assessment. Among the intervention arm, 112 (23%) of 485 women reported past-year physical or sexual intimate partner violence, or both, compared with 119 (27%) of 434 in the control arm (adjusted odds ratio [aOR] 0·69, 95% CI 0·47–1·01; p=0·056). Women in the intervention arm were less likely to report physical intimate partner violence (aOR 0·64, 95% CI 0·41–0·99; p=0·043) and were less likely to express attitudes accepting of intimate partner violence (0·45, 0·34–0·61; p

Published
2019
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5. Measurement of kidney function in Malawi, South Africa, and Uganda: a multicentre cohort study

Author

Fabian, June, Kalyesubula, Robert, Mkandawire, Joseph, Hansen, Christian Holm, Nitsch, Dorothea, Musenge, Eustasius, Nakanga, Wisdom P, Prynn, Josephine E, Dreyer, Gavin, Snyman, Tracy, Ssebunnya, Billy, Ramsay, Michele, Smeeth, Liam, Tollman, Stephen, Naicker, Saraladevi, Crampin, Amelia, Newton, Robert, George, Jaya A, Tomlinson, Laurie, and African Research on Kidney Disease Consortium

Abstract

BACKGROUND: The burden of kidney disease in many African countries is unknown. Equations used to estimate kidney function from serum creatinine have limited regional validation. We sought to determine the most accurate way to measure kidney function and thus estimate the prevalence of impaired kidney function in African populations. METHODS: We measured serum creatinine, cystatin C, and glomerular filtration rate (GFR) using the slope-intercept method for iohexol plasma clearance (mGFR) in population cohorts from Malawi, Uganda, and South Africa. We compared performance of creatinine and cystatin C-based estimating equations to mGFR, modelled and validated a new creatinine-based equation, and developed a multiple imputation model trained on the mGFR sample using age, sex, and creatinine as the variables to predict the population prevalence of impaired kidney function in west, east, and southern Africa. FINDINGS: Of 3025 people who underwent measured GFR testing (Malawi n=1020, South Africa n=986, and Uganda n=1019), we analysed data for 2578 participants who had complete data and adequate quality measurements. Among 2578 included participants, creatinine-based equations overestimated kidney function compared with mGFR, worsened by use of ethnicity coefficients. The greatest bias occurred at low kidney function, such that the proportion with GFR of less than 60 mL/min per 1·73 m2 either directly measured or estimated by cystatin C was more than double that estimated from creatinine. A new creatinine-based equation did not outperform existing equations, and no equation, including the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 race-neutral equation, estimated GFR within plus or minus 30% of mGFR for 75% or more of the participants. Using a model to impute kidney function based on mGFR, the estimated prevalence of impaired kidney function was more than two-times higher than creatinine-based estimates in populations across six countries in Africa. INTERPRETATION: Estimating GFR using serum creatinine substantially underestimates the individual and population-level burden of impaired kidney function in Africa with implications for understanding disease progression and complications, clinical care, and service provision. Scalable and affordable ways to accurately identify impaired kidney function in Africa are urgently needed. FUNDING: The GSK Africa Non-Communicable Disease Open Lab. TRANSLATIONS: For the Luganda, Chichewa and Xitsonga translations of the abstract see Supplementary Materials section.

Published
2022

6. Inclusive heavy-flavour production at central and forward rapidity in Xe–Xe collisions at TeV

Author

K. Schweda, E. Fragiacomo, Ian Gardner Bearden, Daiki Sekihata, Ali Zaman, Z. Buthelezi, Zebo Tang, Linda Vickovic, Nicolo Jacazio, Alexander Kluge, Jian Liu, G. V. Margagliotti, Marco Marquard, Sumit Kumar Saha, Yingchun Zhu, Alexey Kuryakin, Hannah Bossi, Federico Cindolo, Tuva Ora Herenui Richert, Leo Clifford Greiner, Naghmeh Mohammadi, Sebastien Perrin, Zubayer Ahammed, Siyu Tang, Tariq Mahmoud, Sylvain Chapeland, Takuya Kumaoka, Eleazar Cuautle, Rosario Nania, Benedikt Volkel, Mikhail Malaev, Johan Alme, Luciano Ramello, David Dobrigkeit Chinellato, David Olle Rickard Silvermyr, P. F. T. Matuoka, L. Fabbietti, Kirill Lapidus, Ulrich Fuchs, Corrado Gargiulo, Roman Rogalev, Prottoy Das, F. Bock, A. Karasu Uysal, Katie Leanne Graham, Aleksey M. Tikhonov, A. R. Timmins, M. Bombara, Mattia Faggin, Omar Vazquez Rueda, Neelkamal Mallick, Martin Schmidt, Peter Christiansen, Luciano Musa, Yue Shi Lai, Bushra Ali, Q. Y. Shou, Maria Barlou, Erin Frances Gauger, Kunal Garg, Ganesh Jagannath Tambave, Paolo Giubellino, Philippe Crochet, Manuel Colocci, D. Budnikov, Maximiliano Puccio, E. López Torres, Milan Tkacik, Andrey Zarochentsev, C. Hadjidakis, Hadi Hassan, M. Masera, Marco Giacalone, Alexandre Alarcon Do Passo Suaide, A. V. Kazantsev, Amanda Nicole Flores, Y. F. Ryabov, Martin Poghosyan, A. Rustamov, Hyung Kook Kim, Barbara Jacak, Dimitra Andreou, Austin Vincent Harton, L. Nellen, Mohammad Asif Bhat, V. Muccifora, Vit Kucera, C. J. Schmidt, Alexander Philipp Kalweit, T. Peitzmann, G. Boca, Uliana Dmitrieva, Negin Alizadehvandchali, Gennady Zinovjev, Sadhana Dash, Premomoy Ghosh, Konstantin Mikhaylov, Marta Verweij, Rinaldo Rui, M. Mohisin Khan, Borge Svane Nielsen, Jin-Hong Park, Henner Buesching, Vladimir Izucheev, M. Fusco Girard, R. J. Ehlers, Anisa Khatun, Iwona Anna Sputowska, Nur Hussain, Guy Paic, Jonatan Adolfsson, Gian Michele Innocenti, Christos Pliatskas Stylianidis, Sarita Sahoo, Giuseppe Mandaglio, S. L. La Pointe, David H. Evans, Maya Hachiya Shimomura, Emma Gonzalez Hernandez, Alessandro Ferretti, Dieter Røhrich, Pengyao Cui, Nicole Alice Martin, Joshua Leon Konig, Peter Chochula, Partha Pratim Bhaduri, Mukesh Sharma, L. Betev, Johannes Lehrbach, Sven Gotovac, Zabulon Vilakazi, Monika Varga-Kofarago, Andrea Festanti, Matteo Concas, Y. Zhi, A. Maire, Anton Jusko, Ivan Kralik, Miroslav Pikna, Mario Sitta, Seoyoung Noh, Alexandru Florin Dobrin, L. A. P. Moreno, Christoph Mayer, Marie Germain, Michael Jung, Sanghoon Lim, S. K. Ghosh, S. Sadovsky, Christopher Hills, Dushmanta Sahu, Domenico Colella, Sergey Evdokimov, Stefano Piano, Serpil Yalcin, Michael Rudolf Ciupek, Sourav Kundu, Roman Lavicka, Vladimir Samsonov, Victor Jose Gaston Feuillard, A. Harlenderova, Jens Robert Luhder, Giacomo Contin, David Michael Rohr, Artem Shangaraev, Arturo Alejandro Menchaca-Rocha, Vladimir Belyaev, J. T. Blair, Roberto Divia, S. Porteboeuf-Houssais, Yvonne Chiara Pachmayer, Oleg Karavichev, C. Mengke, Purba Bhattacharya, Hushnud Hushnud, Mohd Danish Azmi, Peter Malzacher, L. Aphecetche, Ernst Hellbar, Attiq Ur Rehman, Motoi Inaba, Jin Hee Yoon, Sandeep Dudi, G. Bencedi, Alberto Collu, J. Takahashi, Christine Nattrass, Andreas Michael Mathis, Luciana Bianchi, Silvia Pisano, Zuzana Moravcova, Christophe Furget, Michelangelo Agnello, Z. Rescakova, Jean Willy Andre Cleymans, Volker Lindenstruth, Barbara Antonina Trzeciak, Nilmoni Sarkar, Vladimir Vechernin, Yasir Ali, S. De Pasquale, Abhi Modak, G. de Cataldo, Satoshi Yano, P. La Rocca, Alberto Caliva, Freja Thoresen, Henrique Jose Correia Zanoli, S. P. Sorensen, Jan Rak, Rahul Ramachandran Nair, Filippo Baruffaldi, Alice Elisabeth Ohlson, Jan Honermann, V. Grigoriev, Sergey Filchagin, Marco Bregant, Oskari Antti Matti Saarimaki, A. D. C. Bell Hechavarria, F. Prino, B. Polichtchouk, Diego Stocco, Nicolas Schmidt, Luisa Bergmann, J. de Cuveland, Deepa Thomas, Jacopo Pazzini, Yu. V. Kharlov, Ejiro Naomi Umaka, Takumi Osako, Thomas Janson, Alex Henri Jean Chauvin, Anju Bhasin, Lukas Lautner, Tatsuya Chujo, Marcello Lunardon, J. L. Bazo Alba, Antonio Uras, Elisa Meninno, H. Pereira Da Costa, Sang Un Ahn, Valentina Zaccolo, Hans Rudolf Schmidt, J. Zhu, Jon-Are Saetre, Sergey Kiselev, Paolo Martinengo, O. Vazquez Doce, Adam Ryszard Kisiel, Xiaoming Zhang, Raphaelle Marie Bailhache, Tomas Herman, Serhiy Senyukov, Susanna Costanza, A. M. Gago, Markus Konrad Kohler, Pascal Dillenseger, Magnus Rentsch Ersdal, Edmundo Javier Garcia-Solis, Adela Kravcakova, Preeti Dhankher, C. Ceballos Sanchez, Costin Grigoras, W. Deng, Guido Alexander Willems, Krzysztof Redlich, Yanchun Ding, J. Saini, Carlos Duarte Galvan, D. De Gruttola, A. De Falco, Adrian Fereydon Nassirpour, Ezra Douglas Lesser, Alexander Vodopyanov, Alexandr Tumkin, Buddhadeb Bhattacharjee, Boris Wagner, Sean Murray, Toralf Bernhard Skaali, Y. J. Kwon, Igor Morozov, Kristjan Herlache Gulbrandsen, Pranjal Sarma, Nataliya Topilskaya, Mesut Arslandok, Alexei Khanzadeev, Johannes Peter Wessels, Tatiana Lazareva, Christian Holm Christensen, Germano Bonomi, P. Gianotti, Georgy Tersimonov, X. L. Li, P. Vande Vyvre, Amalia Pop, Sami Sakari Rasanen, Juan Manuel Mejia Camacho, Michael Henry Oliver, F. Torales-Acosta, G. Martínez García, Raquel Estefania Quishpe Quishpe, Mihai Petrovici, Daniel Michael Muhlheim, Ara Grigoryan, Pooja Pareek, Teodor Siemiarczuk, G. A. Feofilov, Somnath Kar, Sebastian Dominik Koryciak, Pietro Cortese, Rita Sadek, Andrei Riabov, Anjaly Sasikumar Menon, Jan Fiete Grosse-Oetringhaus, Oliver Thomas Jevons, Rachid Guernane, Alessandra Fantoni, Geun Hee Hong, Boris Rumyantsev, S. Saha, Sonia Parmar, D. Elia, Bernd Stefan Windelband, Igor Altsybeev, Supriya Das, Artur Furs, Adrian Liu, Angela Badala, Vladislav Manko, C. De Martin, G.L. Usai, Shinichi Hayashi, Hartmut Hillemanns, Imrich Szarka, Minjung Kim, Jan Jadlovsky, Aude Marie Camille Glaenzer, Y. Sekiguchi, Inayat Rasool Bhat, G. Tejeda Muñoz, Nicole Bastid, Lukasz Kamil Graczykowski, R. Alfaro Molina, Sumit Basu, Jhuma Ghosh, Sabyasachi Siddhanta, Valentina Mantovani Sarti, N. Zaviyalov, Ermanno Vercellin, Ran Xu, Jeongsu Bok, Bruno Alessandro, Oliver Matonoha, C. Garabatos, Alberto Masoni, M. Marchisone, Davide Pagano, Sushanta Tripathy, Maria Vasileiou, Seyong Kim, Nicola Zurlo, Varlen Grabski, Josephina Rae Wright, Johanna Stachel, Lucia Anna Husova, Feng Fan, Ankhi Roy, Sizar Aziz, Petra Loncar, Fiorella Maria Celeste Fionda, Sudhir Raniwala, Anand Kumar Dubey, Vladimir Kovalenko, Basanta Kumar Nandi, Y. Mao, Tatiana Karavicheva, Shiming Yang, Sebastian Adam Bysiak, Kristin Fanebust Hetland, Svetlana Kushpil, I. K. Yoo, Bong-Hwi Lim, Shi Qiu, Jacek Tomasz Otwinowski, Marielle Chartier, Chun-Lu Huang, Hira Ilyas, Cristina Terrevoli, Y. Melikyan, M. A. Mazzoni, J. J. Gaardhøje, Muqing Jin, E. Nappi, Zhanna Khabanova, Auro Prasad Mohanty, Ionel Stan, J. S. Kim, Benjamin Donigus, Adrian Florin Mechler, J. R. A. Garcia, Georgui Kornakov, A. Di Mauro, Susan L. Swain, Lucas Altenkamper, Petr Zavada, S. Lee, Lukas Koska, Sanchari Thakur, Sudhir Pandurang Rode, Christina Markert, Przemyslaw Stefan Rokita, Alexandre Shabetai, Jiyeon Kwon, Matthew Daniel Buckland, Cvetan Valeriev Cheshkov, Mohammed Hamid, Tim Sebastian Rogoschinski, Radiy Ilkaev, Peter Braun-Munzinger, Nicole Apadula, Sanjeev Singh Sambyal, Dhruv Utpalkumar Dixit, Dagmar Adamová, Udo Wolfgang Kebschull, Valeriy Pozdniakov, Sandro Christian Wenzel, B. von Haller, Ashik Ikbal Sheikh, Laura Brittany Havener, Lukas Kreis, M. Zhalov, Raimond Snellings, Thomas Michael Cormier, Lokesh Kumar, Subhasis Chattopadhyay, Gabriele Fiorenza, Pascal Dupieux, Andrea Dainese, Mike Henry Petrus Sas, Peter Glassel, Hua Pei, A. Rakotozafindrabe, R. Nayak, Petra Riedler, A. Kondratyev, E. A. R. Casula, Julian Wojciech Myrcha, Francesco Mazzaschi, Jeremy John Wilkinson, D. S. D. Albuquerque, F. Soramel, Arthur Willem Jean Gal, Rainer Arno Ernst Renfordt, Surya Prakash Pathak, Y. Yamaguchi, Agneta Oskarsson, Meike Charlotte Danisch, Sergey Fokin, Ralf Keidel, Petr Nomokonov, Gabor Biro, Sergey Shirinkin, Andrea Ferrero, J. Wiechula, Edgar Dominguez Rosas, Fouad Rami, Savita Sharma, J. W. Harris, Seyed Farid Taghavi, A. Matyja, David Horak, N. Bianchi, Janusz Oleniacz, Silvia Delsanto, Y. Berdnikov, Rashmi Raniwala, Anantachai Lakrathok, Ana Vargas, S. Vergara Limón, Jaehyeon Do, Mohamad Tarhini, Cristiane Jahnke, Peter Levai, G. Hamar, Fabio Catalano, Luca Quaglia, Lukas Tropp, R. Bellwied, Sebastian Hornung, Claude Andre Pruneau, Torsten Alt, Haidar Mas'Ud Alfanda, K. Krizkova Gajdosova, Vytautas Vislavicius, Matthias Kleiner, Irais Bautista Guzman, Evgeny Karpechev, Tomasz Trzcinski, G. Aglieri Rinella, Roberto Barbera, Elena Botta, Bhawani Singh, Mihail Bogdan Blidaru, Philippe Pillot, Corey James Myers, Gergely Gabor Barnafoldi, A. Fernández Téllez, Horst Sebastian Scheid, L. Šerkšnytė, Jerome Jung, Yasuo Miake, Sinjini Chandra, Eugen Mudnic, Klaus Johannes Reygers, Mario Kruger, Natalia Kondratyeva, Silvia Masciocchi, Boris Batyunya, Shiming Yuan, C. Oppedisano, Catalin-Lucian Ristea, D. A. Moreira De Godoy, Roy Crawford Lemmon, Bedangadas Mohanty, Claudiu Cornel Schiaua, Andrea Danu, Guillaume Batigne, Dominik Voscek, Philip Hauer, Federico Ronchetti, Joakim Nystrand, Rabi Soto Camacho, Baidyanath Sahoo, Debjani Banerjee, Mateusz Andrzej Ploskon, Anastasia Berdnikova, Stefano Trogolo, Jana Bielcikova, Michael Karim Habib, Massimo Angeletti, Ophelie Bugnon, Kenta Shigaki, Aditya Nath Mishra, Neetika Sharma, D. Peresunko, Jasper Elias Parkkila, Vitaly Loginov, A. C. Oliveira Da Silva, Vikash Sumberia, J. Castillo Castellanos, Evgeny Ryabinkin, Fernando Antonio Flor, Y. Wu, Jamila Bashir Butt, Davide Caffarri, Y. Sibiriak, Shafiq Ahmad, A. Feliciello, Zoltán Varga, Fabrizio Grosa, Svetlana Belokurova, Patrick Simon Reichelt, Sergey Nazarenko, A. Ortiz Velasquez, Nicolo' Valle, Ana Maria Marin, Robert Vertesi, M. V. Ivanov, Guillermo Mesa Perez, C. Klein-Bösing, Stephan Friedrich Stiefelmaier, Ilya Selyuzhenkov, Adrian Sevcenco, Stefano Panebianco, Bjarte Kileng, J. G. Contreras, Z. Yin, M. Winn, Syaefudin Jaelani, Yongwook Baek, Lidia Maria Gorlich, Kenneth Francis Read, Volodymyr Yurchenko, Filippo Costa, Amelia Lindner, Dmitry Finogeev, M. O. Schmidt, Christian Claude Kuhn, A. S. Nyanin, Oleksandr Kovalenko, Wadut Shaikh, E. Calvo Villar, Giulio Eulisse, Kilian Eberhard Schwarz, Luca Barioglio, Brigitte Cheynis, L. De Cilladi, Stefan Kirsch, Alla Maevskaya, Ahsan Mehmood Khan, Shreyasi Acharya, Renu Bala, H. Appelshäuser, Ketil Røed, Bharati Naik, Thomas Klemenz, Stefania Bufalino, Dibakar Bauri, Sergey Nikulin, Y. Pestov, Michal Sumbera, F. Krizek, T. Dietel, M. I. Martínez, A. B. Kurepin, Sergey Nikolaev, Florian Jonas, Mirko Planinic, Kamil Rafal Deja, Giuseppe Trombetta, Felix Reidt, G. Conesa Balbastre, Peter Martin Jacobs, C. Suire, Mallick Dukhishyam, D. J. Kim, V. Chibante Barroso, Suharyo Sumowidagdo, J.A. Mares, Ritsuya Hosokawa, Constantinos Loizides, Pragati Sahoo, Katharina Garner, Mauro Rogerio Cosentino, Hideki Hamagaki, Masanori Ogino, Jungeol Kim, Raghunath Sahoo, Podist Kurashvili, Maciej Slupecki, Fabian Pliquett, Valerie Ramillien Barret, Mikolaj Krzewicki, Piotr Jan Konopka, Grazia Luparello, Caitlin Beattie, Paraskevi Ganoti, Mohammed Al-Turany, Marian Krivda, F. Carnesecchi, Vladimir Zherebchevskii, Alexander Bolozdynya, Jon Christopher Wikne, Gioacchino Vino, Giacomo Bruno, Charles E. Hughes, Anselmo Margotti, Peter Kalinak, Grzegorz Andrzej Wilk, Kirill Voloshin, Matthias Richter, Y. Zhang, C. Soncco, Michael Lettrich, M. van Leeuwen, Dmitry Serebryakov, Nikola Poljak, Torsten Dahms, Marianna Mazzilli, Adriana Telesca, Patrick John Steffanic, Ante Bilandzic, Robin Albert Andre Caron, Victor Gonzalez, Smbat Grigoryan, James Declan Mulligan, Francesca Bellini, Monika Joanna Jakubowska, James Philip Iddon, G. Herrera Corral, Gvozden Neskovic, Rainer Martin Schicker, Vladimir Ivanov, Goran Simatovic, Debojit Sarkar, Øystein Djuvsland, Lawrence Pinsky, Raffaele Grosso, Gualtiero Volpe, L. Cunqueiro, D. Hatzifotiadou, Predrag Buncic, Laszlo Boldizsar, Dirk Hutter, M. Rodríguez Cahuantzi, Beom Joon Kim, M. J. Kweon, P. G. Jones, Barbara Ewa Erazmus, Fabio Filippo Colamaria, Manuel Guittiere, Ionut Cristian Arsene, Andreas Morsch, M. R. Haque, Austin Robert Schmier, Debasish Das, Andrea Dubla, Xiaozhi Bai, D. L. Mihaylov, Shingo Sakai, Arturo Tauro, Haavard Helstrup, Soyeon Cho, A. Alkin, Zhiqing Zhang, Igor Pshenichnov, I. Das, Vito Manzari, Arvind Khuntia, Viktor Riabov, Vivek Singh, Ranbir Singh, Simon Voigt Nesbø, Antonio Trifiro, Y. Schutz, Giuseppe Simonetti, Shengkun Zhang, Ivan Ravasenga, Ingrid Mckibben Lofnes, Jan Figiel, Alperen Yuncu, Viljar Nilsen Eikeland, Solangel Rojas Torres, Andre Augustinus, Vladimir Nikulin, Ralf Peter Averbeck, S. Beole, Malgorzata Anna Janik, Miljenko Suljic, Rutuparna Rath, Anders Garritt Knospe, L. V. Malinina, Iouri Belikov, Martin Kroesen, Fabio de Moraes Canedo, Piotr Jan Gasik, Roman Lietava, You Zhou, Vikas Singhal, Elisa Laudi, Hermann Franz Degenhardt, Antonino Zichichi, Jorge Andres Lopez Lopez, Guillaume Taillepied, Marcelo Gameiro Munhoz, A. G. Bogdanov, Raul Arteche Diaz, Martin Andreas Volkl, Boris Hippolyte, Vladimir Kaplin, Marek Kowalski, David Karatovic, Saul Anibal Rodriguez Ramirez, Artem Isakov, Sohail Musa Mahmood, Christoph Blume, Andrzej Rybicki, Kosei Yamakawa, Mihaela Gabriela Besoiu, S. R. Klein, M. Guilbaud, Laure Marie Massacrier, Evgeny Kryshen, Esther Bartsch, Alberica Toia, Magnus Mager, Pietro Antonioli, Nima Zardoshti, Siraj Ahmed Khan, Luisa Cifarelli, Giulia Clai, L. H. González-Trueba, Roberto Preghenella, K. Barth, Luuk Vermunt, Mikhail Ippolitov, Livia Terlizzi, Xinye Peng, O. Villalobos Baillie, Christian Lippmann, Luis Gustavo Pereira, Andrey Erokhin, Andrey Vasiliev, Enrico Scomparin, Janet Elizabeth Seger, Bernhard Hohlweger, Francesco Noferini, T. Kollegger, Hiroki Yokoyama, Alexander Borissov, Stefano Boi, Michal Broz, Alberto Rotondi, R. D. Majka, Patrick Huhn, Slavka Jadlovska, J. Schambach, Taku Gunji, Alexander Schmah, Purushottam Chakraborty, J. Porter, Paul Alois Buhler, Aydan Garibli, Jochen Klein, Trine Spedstad Tveter, Ivan Kisel, Pablo Fierro Rojas, A. Baldisseri, Lucrezia Camilla Migliorin, Jakub Kvapil, M. Weber, Arnon Songmoolnak, D. Mal'Kevich, Saikat Biswas, Archana Sharma, Rishat Sultanov, S. T. Heckel, Robert Helmut Munzer, Andrea Alici, Dai-Mei Zhou, Alexander Szabo, Emily Jade Willsher, Cristian Andrei, Venelin Anguelov, Branislav Sitar, D. Varga, Sidharth Kumar Prasad, Annalisa Mastroserio, Kjetil Ullaland, N. De Marco, Lars Bratrud, Francesco Riggi, Panagiota Foka, Dmitrii Nesterov, Tabea Maria Eder, Werner Riegler, T.H. Kim, Alexander Akindinov, J. Klay, Jinjin Pan, Nikolai Smirnov, Raphael Noel Tieulent, Markus Ball, B.S. Onnerstad, Luca Micheletti, Franco Meddi, Dmitry Aleksandrov, Pavel Larionov, Franck Manso, Alexandra Neagu, Chinorat Kobdaj, Arianna Grisel Torres Ramos, Z. Conesa del Valle, Dong Jo Kim, Miguel Arratia, Michal Meres, Tiziano Virgili, Markus Fasel, Przemyslaw Karczmarczyk, Suman Deb, Federico Antinori, Jan Musinsky, Ombretta Pinazza, Piotr Nowakowski, Eunja Kim, Lee Stuart Barnby, Pradip Kumar Sahu, Piero Giubilato, Jan Anton Hasenbichler, Xavier Bernard Lopez, Jaroslav Bielcik, Ryan Patrick Hannigan, Elena Rogochaya, Jacobb Lee Martinez, Anton Andronic, Heidi Maria Rytkonen, Antonio Bianchi, A. De Caro, Florian Paul Andre Damas, Neelima Agrawal, M. S. Islam, Martino Gagliardi, Clara Bartels, D. Di Bari, R. Haake, Ivan Vorobyev, Silvia Arcelli, Jin Joo Seo, Alessandro Grelli, Siegfried Valentin Foertsch, Muhammad Umair Naru, Romain Schotter, Xing Long Li, Jaime Norman, N. van der Kolk, Paolo Camerini, Sergey Voloshin, Mustafa Anaam, D. Miśkowiec, Peter Zahariev Hristov, Ken Oyama, Himanshu Sharma, P. G. Kuijer, Wladyslaw Henryk Trzaska, Madalina-Gabriela Tarzila, Wan Chang, Rosario Turrisi, Evgeny Kondratyuk, Jørgen André Lien, William Edward Witt, Luigi Dello Stritto, Adam Tadeusz Wegrzynek, Bruno Espagnon, A. A. Vinogradov, Ola Slettevoll Groettvik, Cindy Mordasini, Anik Gupta, Alexander Adler, Alessandro Balbino, Norbert Novitzky, Ramona Lea, Jonathan Samuel Colburn, Chiara Pinto, Florian Herrmann, Massimo Lamanna, Sanjib Muhuri, P. Roy, Arseniy Shabanov, Marco Toppi, K. Šafařík, Stephan Alexander Konigstorfer, Jihye Song, Jurgen Schukraft, Victor Trubnikov, Julien Faivre, Andrea Rossi, Hiroshi Murakami, Chiara Zampolli, Sara Vallero, Marko Jercic, Sonali Padhan, Maksim Melnik Storetvedt, Alice Mulliri, Biswarup Paul, L. V. R. van Doremalen, V. Petráček, Ruben Shahoyan, Janka Vrlakova, Pietro Fecchio, Panagiotis Christakoglou, Olja Dordic, T. P. Sinha, Hanna Paulina Zbroszczyk, Toru Sugitate, Yudi Ma, B. Ketzer, Filip Erhardt, Antonina Rosano, I. León Monzón, C. Cicalo, Dmitry Blau, M. Keil, Sergey Gorbunov, A. R. Redelbach, Oveis Sheibani, Rune Langøy, Roberta Arnaldi, Teo Mrnjavac, Tulika Tripathy, Gilda Scioli, Z. Akbar, T. Antičić, Richa Gupta, Sudipan De, D. Berenyi, Martin Vala, Sibaliso Mhlanga, Qasim Waheed Malik, Alexandru Bercuci, Joonil Lee, A. A. Capon, Thomas Humanic, Uzma Tabassam, Simone Ragoni, Rafael Peretti Pezzi, and H. Borel

Subjects
Physics, Nuclear and High Energy Physics, Large Hadron Collider, Muon, Meson, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Hadron, Parton, 01 natural sciences, 7. Clean energy, Nuclear physics, 0103 physical sciences, Quark–gluon plasma, High Energy Physics::Experiment, Rapidity, Impact parameter, Nuclear Experiment, 010306 general physics
Abstract

The first measurements of the production of muons and electrons from heavy-flavour hadron decays in Xe–Xe collisions at sNN=5.44 TeV, using the ALICE detector at the LHC, are reported. The measurement of the nuclear modification factor RAA is performed as a function of transverse momentum pT in several centrality classes at forward rapidity (2.5

Published
2021

7. POS-331 ASSOCIATION OF IMPAIRED KIDNEY FUNCTION WITH MORTALITY IN RURAL UGANDA: RESULTS OF A GENERAL POPULATION COHORT STUDY

Author

Laurie A. Tomlinson, Christian Holm Hansen, P. Hughes, Billy Ssebunya, Janet Seeley, S. Liam, R. Makanga, M. Kwizera Mbonye, Robert Kalyesubula, N. Robert, Keith Tomlin, and Isaac Sekitoleko

Subjects
Nephrology, business.industry, General Population Cohort, Medicine, Renal function, RC870-923, business, Association (psychology), Diseases of the genitourinary system. Urology, Demography
Abstract

Introduction: The burden of kidney disease in sub-Saharan Africa is currently poorly understood. Very limited monitoring and treatment is available for people affected. The association with other diseases and with mortality is unknown in this setting. We sought to determine the association between kidney function and subsequent all-cause mortality. Methods: In a general population cohort with detailed measurement of health-related parameters in rural Uganda, we estimated the baseline glomerular filtration rate (GFR) between 2011-2014 in 5,678 participants. We followed participants up to March 2019 with regular ascertainment of mortality and migration. Using multivariable cox regression, we determined associations between baseline eGFR and mortality. Results: The median age of the participants at baseline was 36 years (IQR 24-50), 60.7% were female, 14.6% hypertensive, 9.7% HIV-positive and 1.8% diabetic. We registered 140 deaths with a median follow-up of 5.0 years. Adjusting for age and sex, HIV, hypertension, diabetes, BMI, marital status, and alcohol and tobacco use participants with eGFR ≤45 mls/min/1.73m2 had six-fold higher mortality compared to those with eGFR ≥90mls/min/1.73m2 (HR 6.12 (95% CI 2.27-16.45)) with strong evidence of a linear trend for risk of mortality as renal function declined (P

Published
2021

8. GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

Author

Torben Hansen, Signe S. Torekov, Christian Theil Have, Ivan Brandslund, Oluf Pedersen, Niels Grarup, Jens J. Holst, Simon Veedfald, Sten Madsbad, Jens-Christian Holm, and Eva W. Iepsen

Subjects
Agonist, Blood Glucose, medicine.medical_specialty, obesity, medicine.drug_class, Denmark, Type 2 diabetes, General Biochemistry, Genetics and Molecular Biology, Glucagon-like peptide-1 receptor agonists, Glucagon-Like Peptide-1 Receptor, Weight loss, Internal medicine, Report, Weight Loss, medicine, Humans, GLP-1 RA, Receptor, Glucagon-like peptide 1 receptor, lcsh:R5-920, liraglutide, business.industry, Liraglutide, Homozygote, MC4R mutation, Middle Aged, medicine.disease, Obesity, Obesity, Morbid, Melanocortin 4 receptor, Endocrinology, Diabetes Mellitus, Type 2, Mutation, Receptor, Melanocortin, Type 4, Female, medicine.symptom, lcsh:Medicine (General), business, medicine.drug
Abstract

Summary Individuals with obesity due to pathogenic heterozygous melanocortin 4 receptor (MC4R) mutations can be treated efficiently with the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide. Here, we report the effect of 16 weeks of liraglutide 3 mg/day treatment in a woman with morbid obesity and type 2 diabetes (T2D) due to homozygous pathogenic MC4R mutation. The body weight loss was 9.7 kg, similar to weight loss in heterozygous MC4R mutation carriers and common obesity. In addition, the treatment led to clinically relevant decreases in fasting glucose, triglycerides, systolic blood pressure, and normalization of glucose tolerance. We conclude that liraglutide reduces body weight and blood glucose levels in hetero- and homozygous MC4R mutation carriers. This serves as proof-of-concept that MC4Rs are not required for the body weight and glucose lowering effects of GLP-1 RAs and that liraglutide may be used as part of the treatment of obesity and T2D due to MC4R mutations., Graphical Abstract, Highlights Liraglutide induces weight loss in a woman homozygous for pathogenic MC4R mutation Glucose tolerance normalized and fasting glucose and triglyceride levels reduced MC4R is not required for GLP-1 RA-mediated weight loss Liraglutide is an effective treatment for the most common form of monogenic obesity, In this case report, Iepsen et al. show that the GLP-1 RA liraglutide induces a weight loss of 10 kg and normalization of glucose tolerance in a woman homozygous for pathogenic MC4R mutation. Thus, the appetite-reducing effects of liraglutide are preserved in MC4R causal obesity and independent of the MC4R pathway.

Published
2020
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9. Exploration of jet substructure using iterative declustering in pp and Pb–Pb collisions at LHC energies

Author

J. Castillo Castellanos, Jamila Bashir Butt, Y. Sibiriak, J. W. Harris, Purushottam Chakraborty, Ilya Selyuzhenkov, Silvia Masciocchi, Suyuan Liu, Vladyslav Litichevskyi, Trine Spedstad Tveter, Ivan Kisel, Ophelie Bugnon, Kenta Shigaki, Christian Claude Kuhn, Renaud Vernet, C. Klein-Bösing, A. S. Nyanin, Christoph Blume, Tomoya Tsuji, Shreyasi Acharya, H. Appelshäuser, Ketil Røed, Sebastian Lehner, Jaime Norman, Jacopo Margutti, Sergey Nikolaev, Giulio Eulisse, Kilian Eberhard Schwarz, Arseniy Shabanov, Andrzej Rybicki, W. J. Llope, Amal Sarkar, C. Suire, Constantinos Loizides, Eugenio Scapparone, Matteo Lupi, Kosei Yamakawa, Ciprian Mihai Mitu, Esther Bartsch, Lucia Leardini, Bharati Naik, Y. Pestov, Felix Reidt, C. Hadjidakis, Hideki Hamagaki, Nima Zardoshti, Silvia Arcelli, M. Buckland, Ejiro Naomi Umaka, Paolo Bartalini, L. O. D. L. Pimentel, V. Chibante Barroso, Raghunath Sahoo, Valerie Ramillien Barret, Jurgen Schukraft, Victor Trubnikov, Julien Faivre, P. F. T. Matuoka, Ulrich Fuchs, Przemyslaw Karczmarczyk, Suman Deb, Federico Antinori, Michael Lettrich, Ali Zaman, Øystein Djuvsland, Marco Marquard, Hiroshi Murakami, Xiaowen Ren, Daniel Michael Muhlheim, Jhuma Ghosh, K. Barth, Luuk Vermunt, G. Contin, Paolo Camerini, Sergey Voloshin, E. Fragiacomo, Ian Gardner Bearden, Daiki Sekihata, Yingchun Zhu, Filimon Roukoutakis, Hannah Bossi, Stefano Piano, Sourav Kundu, Rajendra Nath Patra, Serpil Yalcin, Hushnud Hushnud, Corrado Gargiulo, Manoj Bhanudas Jadhav, Roman Rogalev, Omar Vazquez Rueda, Yue Shi Lai, Fiorella Maria Celeste Fionda, M. Weber, Arnon Songmoolnak, Gerardus Nooren, Jan Musinsky, Ombretta Pinazza, Piotr Nowakowski, Sabyasachi Siddhanta, Shaji Kumar, Saikat Biswas, Mesut Arslandok, C. Garabatos, Alberto Masoni, Mikhail Ippolitov, Archana Sharma, Natalia Zhigareva, Jeremy John Wilkinson, Agneta Oskarsson, Rafael Peretti Pezzi, H. Borel, M. Martinez Pedreira, K. Schweda, Andrea Alici, Tuva Ora Herenui Richert, Markus Bernhard Zimmermann, Siyu Tang, Benedikt Volkel, Serhiy Senyukov, Susanna Costanza, Magnus Rentsch Ersdal, Edmundo Javier Garcia-Solis, Ranjit Nayak, Dai-Mei Zhou, Erin Frances Gauger, Vit Kucera, Z. Buthelezi, V. Grigoriev, Y. Corrales Morales, Yves Roland Schutz, Victor Jose Gaston Feuillard, Pascal Dillenseger, Cristian Andrei, Mikhail Malaev, M. G. D. L. C. Vicencio, Venelin Anguelov, Eliane Epple, Rama Chandra Baral, Livio Bianchi, Sumit Kumar Saha, Federico Cindolo, Alwina Ruixin Liu, Premomoy Ghosh, Konstantin Mikhaylov, Sudhir Pandurang Rode, Jana Crkovská, Zhiqing Zhang, Raphaelle Marie Bailhache, A. Karasu Uysal, Harry Arthur Andrews, D. Miśkowiec, Jan Fiete Grosse-Oetringhaus, Prabhakar Palni, Rosario Nania, Aleksey M. Tikhonov, M. Bombara, Ermanno Vercellin, M. Mohisin Khan, Y. Mao, Borge Svane Nielsen, Alexander Kluge, D. Budnikov, Pietro Fecchio, Vardanush Papikyan, R. Alfaro Molina, Krystian Roslon, Igor Altsybeev, Anisa Khatun, Iwona Anna Sputowska, Nur Hussain, Paolo Giubellino, Philippe Crochet, Davide Pagano, Jesse Thomas Buxton, Guy Paic, Linda Vickovic, G. V. Margagliotti, M. A. Mazzoni, Tahir Hussain, Toralf Bernhard Skaali, Emma Gonzalez Hernandez, Alessandro Ferretti, David Michael Rohr, Dimitra Andreou, F. Soramel, A. Matyja, Janusz Oleniacz, Y. Berdnikov, Michael Henry Oliver, Laurent Bernard Aphecetche, Martin Poghosyan, Austin Vincent Harton, Krzysztof Redlich, Yanchun Ding, Sami Sakari Rasanen, Marielle Chartier, J. S. Kim, Artem Shangaraev, J. L. Klay, A. Rustamov, Adrian Florin Mechler, Barbara Jacak, Alexander Philipp Kalweit, Johannes Lehrbach, Tasnuva Chowdhury, C. J. Schmidt, Seyong Kim, Alexander Akindinov, Vicente González, Dagmar Adamová, Uliana Dmitrieva, Peter Glassel, Manuel Colocci, A. Villatoro Tello, Panagiotis Christakoglou, F. Torales-Acosta, G. Martínez García, Xuan Zhang, E. López Torres, Ashutosh Pandey, Eunja Kim, Matteo Concas, Souvik Priyam Adhya, Leo Clifford Greiner, Christian Bourjau, Silvia Delsanto, Jacek Tomasz Otwinowski, Zhanna Khabanova, P. González-Zamora, Philipp Johannes Luettig, Masanori Ogino, Peter Zahariev Hristov, Ken Oyama, Peter Chochula, Ana Vargas, Danthasinghe Piyarathna, Vytautas Vislavicius, Mais Kazim Oglu Suleymanov, Thomas Michael Cormier, Lokesh Kumar, Hua Pei, Attiq Ur Rehman, Bruno Alessandro, Mukesh Sharma, Z. Conesa del Valle, Pragati Sahoo, Priyanka Sett, Motoi Inaba, Sk Noor Alam, Jin Hee Yoon, Marian Krivda, Irais Bautista Guzman, S. Sadovsky, Christopher Hills, Domenico Colella, Yuri Melikyan, Olja Dordic, Nicole Apadula, Evgeny Karpechev, Tomasz Trzcinski, N. Zaviyalov, Udo Wolfgang Kebschull, S. Yano, Grzegorz Andrzej Wilk, D. M. Goméz Coral, Andrey Zarochentsev, Gabriele Fiorenza, Pascal Dupieux, Andrea Dainese, Sergey Fokin, Naghmeh Mohammadi, David Dobrigkeit Chinellato, Zubayer Ahammed, Catherine Micaela Silvestre, X. L. Li, Elena Bruna, Brennan Schaefer, Steffen Georg Weber, Sudhir Raniwala, Matthias Richter, Vladimir Belyaev, J. T. Blair, Ante Bilandzic, G. Herrera Corral, Gennady Zinovjev, Roberto Divia, A. Gomez Ramirez, Maya Hachiya Shimomura, Tatiana Karavicheva, T. P. Sinha, G. Aglieri Rinella, Tomas Wilhelm Snellman, Hanna Paulina Zbroszczyk, Joakim Nystrand, Xinye Peng, Sadhana Dash, Dieter Røhrich, Hendrik Poppenborg, A. Maire, Anton Jusko, M. R. Haque, A. De Falco, Adrian Fereydon Nassirpour, Gabriele Gaetano Fronze, Boris Batyunya, Lawrence Pinsky, Shiming Yuan, Jochen Klein, Ivan Kralik, Miroslav Pikna, Vladimir Samsonov, Christine Nattrass, L. Cunqueiro, Mario Sitta, Torsten Alt, Bogdan Theodor Rascanu, D. A. Moreira De Godoy, Oleg Karavichev, David Olle Rickard Silvermyr, M. Masera, K. Krizkova Gajdosova, O. Villalobos Baillie, Christian Lippmann, Tatiana Lazareva, Luis Gustavo Pereira, Martin Schmidt, Christian Holm Christensen, Ionel Stan, S. De Pasquale, Freja Thoresen, Nicole Alice Martin, Toru Sugitate, S. Porteboeuf-Houssais, Sandro Christian Wenzel, Sergey Kiselev, Barbara Guerzoni, Peter Christiansen, J. L. Bazo Alba, Martin Vala, Jongsik Eum, Chengxin Zhao, Claudiu Cornel Schiaua, Sandra Moretto, Z. Yin, Syaefudin Jaelani, M. O. Schmidt, Mohammed Hamid, Andrey Erokhin, Nicolo Jacazio, Germano Bonomi, Alexander Mamonov, Michelangelo Agnello, S. W. Lindsay, Roy Crawford Lemmon, Tapan K. Nayak, Andrey Vasiliev, Andreas Morsch, Shingo Sakai, Yvonne Chiara Pachmayer, Andrea Danu, Konstantin Munning, Dario Berzano, Jinjin Pan, Guillaume Batigne, Massimo Angeletti, Johan Alme, Luciano Ramello, P. Gianotti, Meike Charlotte Danisch, Klaus Johannes Reygers, Astrid Morreale, Ajay Kumar Dash, Laura Fabbietti, Dominik Voscek, T. Peitzmann, Vladimir Zherebchevskii, Sang Un Ahn, Vivek Singh, Sibaliso Mhlanga, G. Boca, Dibakar Bauri, P. Vande Vyvre, Jan Jadlovsky, Ahsan Mehmood Khan, Sumit Basu, Tatsuya Chujo, E. Perez Lezama, Enrico Scomparin, J. Pluta, Evgeny Ryabinkin, Mallick Dukhishyam, Daniel Berenyi, Andrei Ionut Herghelegiu, Heiko Engel, J. Wiechula, Qasim Waheed Malik, Lucia Anna Husova, Alexandru Bercuci, Mohamad Tarhini, Cristiane Jahnke, Valentina Zaccolo, Hans Rudolf Schmidt, Paolo Martinengo, Luca Micheletti, Teodor Siemiarczuk, Sonia Parmar, Marton Vargyas, Mario Kruger, Jussi Samuli Viinikainen, Dmitry Finogeev, Federico Ronchetti, P. G. Kuijer, Jana Bielcikova, Wanchaloem Poonsawat, Y. F. Ryabov, J.A. Mares, Wladyslaw Henryk Trzaska, Madalina-Gabriela Tarzila, J. Zhu, Andre Mischke, Beomsu Chang, Corey James Myers, Grazia Luparello, Volodymyr Yurchenko, Paraskevi Ganoti, Mohammed Al-Turany, Antonija Utrobicic, Renu Bala, O. Vazquez Doce, Franco Meddi, Mohd Danish Azmi, Dmitry Aleksandrov, Pavel Larionov, Anthony Robert Timmins, Peter Malzacher, Adam Ryszard Kisiel, R. D. De Souza, Pooja Pareek, R. Orava, Franck Manso, C. Oppedisano, Chinorat Kobdaj, Catalin-Lucian Ristea, Pranjal Sarma, Nikolai Smirnov, B. Ketzer, E. Nappi, Susan L. Swain, Lucas Altenkamper, Janet Elizabeth Seger, Robert Vertesi, Bjarte Kileng, M. van Leeuwen, Costin Grigoras, Cindy Mordasini, Fabrizio Grosa, Michal Sumbera, A. A. P. Suaide, F. Bock, Bushra Ali, Q. Y. Shou, Peter Kalinak, Sona Pochybova, Valery Punin, Bernhard Hohlweger, Hadi Hassan, Raphael Noel Tieulent, Marianna Mazzilli, Adriana Telesca, Patrick John Steffanic, Boris Rumyantsev, Vojtech Pacik, Francesco Noferini, Rene Bellwied, Mauro Rogerio Cosentino, Sibaji Raha, Filip Erhardt, Chiara Zampolli, Sara Vallero, Dong Jo Kim, Goran Simatovic, Vitaly Loginov, Annika Passfeld, Florian Jonas, A. A. Capon, Alexander Bolozdynya, Anik Gupta, Uzma Tabassam, Markus Ball, Alexander Adler, Daniel Dabrowski, Wan Chang, Fabio Filippo Colamaria, S. Balouza, Mihaela Gabriela Besoiu, Marko Jercic, Xiaozhi Bai, Y. Wu, Markus Konrad Kohler, Miguel Arratia, Kamil Rafal Deja, Dmitry Mal'kevich, Maria Vasileiou, A. M. Rossi, Anders Garritt Knospe, Michal Meres, Tiziano Virgili, Markus Fasel, Monika Joanna Jakubowska, Jungeol Kim, Dirk Hutter, Julian Wojciech Myrcha, M. Rodríguez Cahuantzi, Yongwook Baek, Lidia Maria Gorlich, Arthur Willem Jean Gal, Rainer Arno Ernst Renfordt, Andrew Michael Kubera, Alberica Toia, Kenneth Francis Read, Magnus Mager, Florian Herrmann, Nicola Zurlo, Vladimir Kovalenko, Simone Ragoni, Maksim Melnik Storetvedt, L. V. Malinina, Iouri Belikov, Thomas Dietel, Pietro Antonioli, Petr Nomokonov, F. Carnesecchi, Roman Lietava, David Horak, Rashmi Raniwala, Peter Graham Jones, You Zhou, Shiming Yang, Luisa Cifarelli, Sebastian Hornung, Claude Andre Pruneau, Roberto Barbera, Ionut Cristian Arsene, M. J. Kweon, D. L. Mihaylov, Kunal Garg, Maximiliano Puccio, Raimond Snellings, Smbat Grigoryan, Gvozden Neskovic, Rainer Martin Schicker, Sanjib Muhuri, P. Roy, Robert Helmut Munzer, Biswarup Paul, Elena Botta, Sohail Musa Mahmood, C. Soncco, Dmitry Serebryakov, Nikola Poljak, Torsten Dahms, Marco Toppi, Rosario Turrisi, Evgeny Kondratyuk, Stefania Bufalino, Theo Alexander Broker, Jasper Elias Parkkila, M. M. Mondal, Auro Prasad Mohanty, Zhuo Zhou, S. K. Ghosh, Philip Hauer, Debojit Sarkar, Sergey Shirinkin, Arturo Tauro, Syed Asad Hussain, Soyeon Cho, Julius Maximilian Gronefeld, A. Dashi, Rabi Soto Camacho, Manuel Guittiere, Andrzej Deloff, A. J. Castro, A. M. Gago, R. A. Negrao De Oliveira, Guillermo Mesa Perez, L. V. R. van Doremalen, Podist Kurashvili, A. Di Mauro, Oleksandr Kovalenko, Y. J. Kwon, Benjamin Donigus, Guido Alexander Willems, Stefan Thomas Heckel, Haidar Mas'Ud Alfanda, Nataliya Topilskaya, Igor Pshenichnov, Sonia Rajput, I. Das, L. Nellen, Jihye Song, V. Petráček, Ruben Shahoyan, Jonatan Adolfsson, Michael Linus Knichel, Janka Vrlakova, Ana Maria Marin, Wadut Shaikh, Peter Braun-Munzinger, Sanjeev Singh Sambyal, Giuseppe Trombetta, G. Conesa Balbastre, Alexei Khanzadeev, Himani Bhatt, Peter Martin Jacobs, Ran Xu, Johanna Stachel, Solangel Rojas Torres, Jørgen André Lien, William Edward Witt, Adam Tadeusz Wegrzynek, Andre Augustinus, Jon Christopher Wikne, Gioacchino Vino, Alexander Szabo, Filip Krizek, Giacomo Bruno, Charles E. Hughes, B. Espagnon, D. Hatzifotiadou, Bedangadas Mohanty, Predrag Buncic, Laszlo Boldizsar, J. Takahashi, Michael Karim Habib, Valeriy Pozdniakov, Sven Gotovac, Zabulon Vilakazi, Cvetan Valeriev Cheshkov, Radiy Ilkaev, Surya Prakash Pathak, Annelies Marianne Veen, Vito Manzari, Fatiha Lehas, Ashik Ikbal Sheikh, Lukas Kreis, Arvind Khuntia, Viktor Riabov, Fouad Rami, Emily Jade Willsher, Roman Lavicka, Håvard Helstrup, Ingrid Mckibben Lofnes, Lukas Tropp, Jan Figiel, Alperen Yuncu, Branislav Sitar, Sidharth Kumar Prasad, H. Natal da Luz, Annalisa Mastroserio, Marie Germain, E. Stenlund, Philippe Rosnet, A. Kondratyev, E. A. R. Casula, A. A. Vinogradov, Ola Slettevoll Groettvik, Kjetil Ullaland, N. De Marco, Ralf Keidel, Ritsuya Hosokawa, Lukasz Kamil Graczykowski, Adrian Sevcenco, Stefano Panebianco, J. Sochan, S. Vergara Limón, Sandeep Dudi, Arturo Alejandro Menchaca-Rocha, Lars Bratrud, Supriya Das, Francesco Riggi, Artur Furs, Vladislav Manko, Ernst Hellbar, Panagiota Foka, Valentina Mantovani Sarti, Vladimir Peskov, A. Fernández Téllez, Horst Sebastian Scheid, Petra Loncar, Peter Levai, I. K. Yoo, Lukas Koska, Marcello Borri, Ezra Douglas Lesser, Alexander Vodopyanov, Alexandr Tumkin, Alexandre Shabetai, Jiyeon Kwon, Michal Sefcik, Basanta Kumar Nandi, Petra Riedler, Svein Lindal, Natalia Kondratyeva, Mateusz Andrzej Ploskon, Eleazar Cuautle, Antonio Uras, Edgar Dominguez Rosas, Andreas Michael Mathis, Rishat Sultanov, Christopher Daniel Anson, Peter Strmen, Elisa Meninno, Gergely Gabor Barnafoldi, H. Pereira Da Costa, Fabio Catalano, Rafay Anwar, Neetika Sharma, D. Peresunko, Ramona Lea, Kirill Voloshin, Nilmoni Sarkar, Vladimir Vechernin, Yasir Ali, Kristin Fanebust Hetland, Svetlana Kushpil, C. de Conti, S. Dani, Werner Riegler, T.H. Kim, Sushanta Tripathy, Sarita Sahoo, Filippo Costa, Y. Sekiguchi, Rathijit Biswas, Inayat Rasool Bhat, Pietro Cortese, I. León Monzón, G. Tejeda Muñoz, Cristina Terrevoli, Taku Gunji, C. Cicalo, Maciej Slupecki, Piotr Jan Konopka, James Declan Mulligan, T. J. Humanic, L. A. P. Moreno, Christoph Mayer, Suharyo Sumowidagdo, Dmitry Blau, K. Šafařík, Preeti Dhankher, Kristjan Herlache Gulbrandsen, M. Keil, Alexander Schmah, Gualtiero Volpe, Sampo Saarinen, Barbara Ewa Erazmus, U. Frankenfeld, Jens Robert Luhder, Sergey Gorbunov, Andrea Dubla, Hermann Franz Degenhardt, R. T. Jimenez Bustamante, Oliver Thomas Jevons, L. Massacrier, R. Varma, Sizar Aziz, Anton Alkin, Giuseppe Simonetti, Ivan Ravasenga, Katie Leanne Graham, Ralf Peter Averbeck, S. Beole, Filippo Baruffaldi, Linus Feldkamp, Andres Sandoval, Johannes Peter Wessels, M. H. P. Sas, Raymond James Ehlers, Rune Langøy, Raul Arteche Diaz, Dennis Franz Weiser, Martin Andreas Volkl, Roberta Arnaldi, Sergey Filchagin, Marco Bregant, Paul Alois Buhler, Aydan Garibli, Alexandru Florin Dobrin, Vladimir Nikulin, Cristina Bedda, F. Prino, B. Polichtchouk, Dhananjaya Thakur, Teo Mrnjavac, Mattia Faggin, Tulika Tripathy, Boris Hippolyte, Christophe Furget, Luciano Musa, Jean Willy Andre Cleymans, Volker Lindenstruth, Sean Murray, Barbara Antonina Trzeciak, M. M. Mieskolainen, S. R. Klein, H. J. C. Zanoli, Gilda Scioli, Gabor Biro, Evgeny Kryshen, T. Antičić, Richa Gupta, Sudipan De, P. La Rocca, Alberto Caliva, A. Baldisseri, S. P. Sorensen, Nicolas Schmidt, Dezso Varga, Sebastian Klewin, Siraj Ahmed Khan, Jakub Kvapil, Alex Henri Jean Chauvin, K. Puranapanda, D. De Gruttola, Erwann Masson, Mihai Petrovici, Ara Grigoryan, E. Serradilla, D. Elia, Bernd Stefan Windelband, Varlen Grabski, E. Calvo Villar, Bong-Hwi Lim, Vladimir Izucheev, Viktor Ratza, Stefan Kirsch, Sergey Nikulin, S. Lee, B. von Haller, Piotr Jan Gasik, Vikas Singhal, A. Harlenderova, Antonino Zichichi, Guillaume Taillepied, Marcelo Gameiro Munhoz, Valeria Muccifora, A. G. Bogdanov, Jan Rak, Vladimir Kaplin, Rahul Ramachandran Nair, Marek Kowalski, Chun-Lu Huang, Yu. V. Kharlov, Petr Zavada, M. A. Lisa, Gyula Bencedi, Christina Markert, Przemyslaw Stefan Rokita, Paul Christoph Bätzing, A. Rakotozafindrabe, D. S. D. Albuquerque, G. Hamar, Adela Kravcakova, Yasuo Miake, Sinjini Chandra, Aditya Nath Mishra, Fernando Antonio Flor, Davide Caffarri, A. Ortiz Velasquez, Nicolo' Valle, Stefano Bagnasco, M. V. Ivanov, J. G. Contreras, Alla Maevskaya, M. I. Martínez, A. B. Kurepin, Mirko Planinic, Katharina Garner, Francesca Bellini, James Philip Iddon, Vladimir Ivanov, Beom Joon Kim, G. L. Usai, Tariq Mahmoud, Sylvain Chapeland, Rinaldo Rui, M. Fusco Girard, Sergey Evdokimov, Alberto Collu, Samrangy Sadhu, Philippe Pillot, Baidyanath Sahoo, H.B. Kim, Rudiger Haake, Stefano Trogolo, D. S. Hwang, A. Feliciello, Patrick Simon Reichelt, Sergey Nazarenko, Luca Barioglio, Brigitte Cheynis, Carsten Klein, D. J. Kim, Ken Suzuki, Anselmo Margotti, Carlos Duarte Galvan, Buddhadeb Bhattacharjee, Boris Wagner, Silvia Pisano, G. de Cataldo, Raquel Estefania Quishpe Quishpe, Alessandra Fantoni, Angela Badala, Hartmut Hillemanns, Yosuke Watanabe, Anand Kumar Dubey, Muqing Jin, Sanchari Thakur, Shinichi Hayashi, P. W. Stankus, C. Ceballos Sanchez, Austin Robert Schmier, Debasish Das, Ranbir Singh, Simon Voigt Nesbø, Malgorzata Anna Janik, Rutuparna Rath, Timo Eero Hilden, Elisa Laudi, Kirill Lapidus, Antoine Xavier Lardeux, J. P. Revol, Ganesh Jagannath Tambave, Jin-Hong Park, Henner Buesching, Erik Brücken, S. L. La Pointe, David H. Evans, Monika Varga-Kofarago, Andrea Festanti, Diego Stocco, J. de Cuveland, Deepa Thomas, Andrey Reshetin, Sukalyan Chattopadhyay, Marcello Lunardon, J. Saini, Roberto Preghenella, Amalia Pop, Rachid Guernane, Imrich Szarka, Minjung Kim, Nicole Bastid, M. Marchisone, Ankhi Roy, Latchezar Betev, J. J. Gaardhøje, Redmer Alexander Bertens, Lee Stuart Barnby, Pradip Kumar Sahu, Piero Giubilato, Alice Elisabeth Ohlson, Jan Anton Hasenbichler, Xavier Bernard Lopez, Jaroslav Bielcik, Ryan Patrick Hannigan, Elena Rogochaya, Jacobb Lee Martinez, Anton Andronic, Heidi Maria Rytkonen, Mitali Mondal, Antonio Bianchi, A. De Caro, Florian Paul Andre Damas, Ivan Vorobyev, Alessandro Grelli, Siegfried Valentin Foertsch, Muhammad Umair Naru, Xing Long Li, N. van der Kolk, A. C. Oliveira Da Silva, Nicola Bianchi, Mustafa Anaam, Madan M. Aggarwal, E. Widmann, A. Borissov, Neelima Agrawal, M. S. Islam, Martino Gagliardi, Nirbhay Kumar Behera, D. Di Bari, T. Kollegger, J. H. Kang, Hiroki Yokoyama, Michal Broz, Alberto Rotondi, R. D. Majka, Patrick Huhn, Slavka Jadlovska, J. Schambach, Anju Bhasin, G. A. Feofilov, Somnath Kar, M. Zhalov, Andrea Ferrero, Shafiq F. Ahmad, Fabian Pliquett, Mikolaj Krzewicki, Raffaele Grosso, Miljenko Suljic, Shuaib Ahmad Khan, Eugen Mudnic, Jorn Henning Putschke, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), ALICE, Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Acharya S., Adamova D., Adhya S.P., Adler A., Adolfsson J., Aggarwal M.M., Aglieri Rinella G., Agnello M., Agrawal N., Ahammed Z., Ahmad S., Ahn S.U., Akindinov A., Al-Turany M., Alam S.N., Albuquerque D.S.D., Aleksandrov D., Alessandro B., Alfanda H.M., Alfaro Molina R., Ali B., Ali Y., Alici A., Alkin A., Alme J., Alt T., Altenkamper L., Altsybeev I., Anaam M.N., Andrei C., Andreou D., Andrews H.A., Andronic A., Angeletti M., Anguelov V., Anson C., Anticic T., Antinori F., Antonioli P., Anwar R., Apadula N., Aphecetche L., Appelshauser H., Arcelli S., Arnaldi R., Arratia M., Arsene I.C., Arslandok M., Augustinus A., Averbeck R., Aziz S., Azmi M.D., Badala A., Baek Y.W., Bagnasco S., Bai X., Bailhache R., Bala R., Baldisseri A., Ball M., Balouza S., Baral R.C., Barbera R., Barioglio L., Barnafoldi G.G., Barnby L.S., Barret V., Bartalini P., Barth K., Bartsch E., Baruffaldi F., Bastid N., Basu S., Batigne G., Batyunya B., Batzing P.C., Bauri D., Bazo Alba J.L., Bearden I.G., Bedda C., Behera N.K., Belikov I., Bellini F., Bellwied R., Belyaev V., Bencedi G., Beole S., Bercuci A., Berdnikov Y., Berenyi D., Bertens R.A., Berzano D., Besoiu M.G., Betev L., Bhasin A., Bhat I.R., Bhatt H., Bhattacharjee B., Bianchi A., Bianchi L., Bianchi N., Bielcik J., Bielcikova J., Bilandzic A., Biro G., Biswas R., Biswas S., Blair J.T., Blau D., Blume C., Boca G., Bock F., Bogdanov A., Boldizsar L., Bolozdynya A., Bombara M., Bonomi G., Borel H., Borissov A., Borri M., Bossi H., Botta E., Bourjau C., Bratrud L., Braun-Munzinger P., Bregant M., Broker T.A., Broz M., Brucken E.J., Bruna E., Bruno G.E., Buckland M.D., Budnikov D., Buesching H., Bufalino S., Bugnon O., Buhler P., Buncic P., Buthelezi Z., Butt J.B., Buxton J.T., Caffarri D., Caliva A., Calvo Villar E., Camacho R.S., Camerini P., Capon A.A., Carnesecchi F., Castillo Castellanos J., Castro A.J., Casula E.A.R., Catalano F., Ceballos Sanchez C., Chakraborty P., Chandra S., Chang B., Chang W., Chapeland S., Chartier M., Chattopadhyay S., Chauvin A., Cheshkov C., Cheynis B., Chibante Barroso V., Chinellato D.D., Cho S., Chochula P., Chowdhury T., Christakoglou P., Christensen C.H., Christiansen P., Chujo T., Cicalo C., Cifarelli L., Cindolo F., Cleymans J., Colamaria F., Colella D., Collu A., Colocci M., Concas M., Conesa Balbastre G., Conesa del Valle Z., Contin G., Contreras J.G., Cormier T.M., Corrales Morales Y., Cortese P., Cosentino M.R., Costa F., Costanza S., Crkovska J., Crochet P., Cuautle E., Cunqueiro L., Dabrowski D., Dahms T., Dainese A., Damas F.P.A., Dani S., Danisch M.C., Danu A., Das D., Das I., Das S., Dash A., Dash S., Dashi A., De S., De Caro A., de Cataldo G., de Conti C., de Cuveland J., De Falco A., De Gruttola D., De Marco N., De Pasquale S., De Souza R.D., Deb S., Degenhardt H.F., Deja K.R., Deloff A., Delsanto S., Dhankher P., Di Bari D., Di Mauro A., Diaz R.A., Dietel T., Dillenseger P., Ding Y., Divia R., Djuvsland O., Dmitrieva U., Dobrin A., Donigus B., Dordic O., Dubey A.K., Dubla A., Dudi S., Dukhishyam M., Dupieux P., Ehlers R.J., Elia D., Engel H., Epple E., Erazmus B., Erhardt F., Erokhin A., Ersdal M.R., Espagnon B., Eulisse G., Eum J., Evans D., Evdokimov S., Fabbietti L., Faggin M., Faivre J., Fantoni A., Fasel M., Fecchio P., Feldkamp L., Feliciello A., Feofilov G., Fernandez Tellez A., Ferrero A., Ferretti A., Festanti A., Feuillard V.J.G., Figiel J., Filchagin S., Finogeev D., Fionda F.M., Fiorenza G., Flor F., Foertsch S., Foka P., Fokin S., Fragiacomo E., Frankenfeld U., Fronze G.G., Fuchs U., Furget C., Furs A., Fusco Girard M., Gaardhoje J.J., Gagliardi M., Gago A.M., Gal A., Galvan C.D., Ganoti P., Garabatos C., Garcia-Solis E., Garg K., Gargiulo C., Garibli A., Garner K., Gasik P., Gauger E.F., Gay Ducati M.B., Germain M., Ghosh J., Ghosh P., Ghosh S.K., Gianotti P., Giubellino P., Giubilato P., Glassel P., Gomez Coral D.M., Gomez Ramirez A., Gonzalez V., Gonzalez-Zamora P., Gorbunov S., Gorlich L., Gotovac S., Grabski V., Graczykowski L.K., Graham K.L., Greiner L., Grelli A., Grigoras C., Grigoriev V., Grigoryan A., Grigoryan S., Groettvik O.S., Gronefeld J.M., Grosa F., Grosse-Oetringhaus J.F., Grosso R., Guernane R., Guerzoni B., Guittiere M., Gulbrandsen K., Gunji T., Gupta A., Gupta R., Guzman I.B., Haake R., Habib M.K., Hadjidakis C., Hamagaki H., Hamar G., Hamid M., Hannigan R., Haque M.R., Harlenderova A., Harris J.W., Harton A., Hasenbichler J.A., Hassan H., Hatzifotiadou D., Hauer P., Hayashi S., Heckel S.T., Hellbar E., Helstrup H., Herghelegiu A., Hernandez E.G., Herrera Corral G., Herrmann F., Hetland K.F., Hilden T.E., Hillemanns H., Hills C., Hippolyte B., Hohlweger B., Horak D., Hornung S., Hosokawa R., Hristov P., Huang C., Hughes C., Huhn P., Humanic T.J., Hushnud H., Husova L.A., Hussain N., Hussain S.A., Hussain T., Hutter D., Hwang D.S., Iddon J.P., Ilkaev R., Inaba M., Ippolitov M., Islam M.S., Ivanov M., Ivanov V., Izucheev V., Jacak B., Jacazio N., Jacobs P.M., Jadhav M.B., Jadlovska S., Jadlovsky J., Jaelani S., Jahnke C., Jakubowska M.J., Janik M.A., Jercic M., Jevons O., Jimenez Bustamante R.T., Jin M., Jonas F., Jones P.G., Jusko A., Kalinak P., Kalweit A., Kang J.H., Kaplin V., Kar S., Karasu Uysal A., Karavichev O., Karavicheva T., Karczmarczyk P., Karpechev E., Kebschull U., Keidel R., Keil M., Ketzer B., Khabanova Z., Khan A.M., Khan S., Khan S.A., Khanzadeev A., Kharlov Y., Khatun A., Khuntia A., Kileng B., Kim B., Kim D., Kim D.J., Kim E.J., Kim H., Kim J., Kim J.S., Kim M., Kim S., Kim T., Kirsch S., Kisel I., Kiselev S., Kisiel A., Klay J.L., Klein C., Klein J., Klein S., Klein-Bosing C., Klewin S., Kluge A., Knichel M.L., Knospe A.G., Kobdaj C., Kohler M.K., Kollegger T., Kondratyev A., Kondratyeva N., Kondratyuk E., Konopka P.J., Koska L., Kovalenko O., Kovalenko V., Kowalski M., Kralik I., Kravcakova A., Kreis L., Krivda M., Krizek F., Krizkova Gajdosova K., Kruger M., Kryshen E., Krzewicki M., Kubera A.M., Kucera V., Kuhn C., Kuijer P.G., Kumar L., Kumar S., Kundu S., Kurashvili P., Kurepin A., Kurepin A.B., Kushpil S., Kvapil J., Kweon M.J., Kwon J.Y., Kwon Y., La Pointe S.L., La Rocca P., Lai Y.S., Langoy R., Lapidus K., Lardeux A., Larionov P., Laudi E., Lavicka R., Lazareva T., Lea R., Leardini L., Lee S., Lehas F., Lehner S., Lehrbach J., Lemmon R.C., Leon Monzon I., Lesser E.D., Lettrich M., Levai P., Li X., Li X.L., Lien J., Lietava R., Lim B., Lindal S., Lindenstruth V., Lindsay S.W., Lippmann C., Lisa M.A., Litichevskyi V., Liu A., Liu S., Llope W.J., Lofnes I.M., Loginov V., Loizides C., Loncar P., Lopez X., Lopez Torres E., Luettig P., Luhder J.R., Lunardon M., Luparello G., Lupi M., Maevskaya A., Mager M., Mahmood S.M., Mahmoud T., Maire A., Majka R.D., Malaev M., Malik Q.W., Malinina L., Mal'Kevich D., Malzacher P., Mamonov A., Manko V., Manso F., Manzari V., Mao Y., Marchisone M., Mares J., Margagliotti G.V., Margotti A., Margutti J., Marin A., Markert C., Marquard M., Martin N.A., Martinengo P., Martinez J.L., Martinez M.I., Martinez Garcia G., Martinez Pedreira M., Masciocchi S., Masera M., Masoni A., Massacrier L., Masson E., Mastroserio A., Mathis A.M., Matuoka P.F.T., Matyja A., Mayer C., Mazzilli M., Mazzoni M.A., Mechler A.F., Meddi F., Melikyan Y., Menchaca-Rocha A., Meninno E., Meres M., Mhlanga S., Miake Y., Micheletti L., Mieskolainen M.M., Mihaylov D.L., Mikhaylov K., Mischke A., Mishra A.N., Miskowiec D., Mitu C.M., Mohammadi N., Mohanty A.P., Mohanty B., Mohisin Khan M., Mondal M., Mondal M.M., Mordasini C., Moreira De Godoy D.A., Moreno L.A.P., Moretto S., Morreale A., Morsch A., Mrnjavac T., Muccifora V., Mudnic E., Muhlheim D., Muhuri S., Mulligan J.D., Munhoz M.G., Munning K., Munzer R.H., Murakami H., Murray S., Musa L., Musinsky J., Myers C.J., Myrcha J.W., Naik B., Nair R., Nandi B.K., Nania R., Nappi E., Naru M.U., Nassirpour A.F., Natal da Luz H., Nattrass C., Nayak R., Nayak T.K., Nazarenko S., Negrao De Oliveira R.A., Nellen L., Nesbo S.V., Neskovic G., Nielsen B.S., Nikolaev S., Nikulin S., Nikulin V., Noferini F., Nomokonov P., Nooren G., Norman J., Nowakowski P., Nyanin A., Nystrand J., Ogino M., Ohlson A., Oleniacz J., Oliveira Da Silva A.C., Oliver M.H., Oppedisano C., Orava R., Ortiz Velasquez A., Oskarsson A., Otwinowski J., Oyama K., Pachmayer Y., Pacik V., Pagano D., Paic G., Palni P., Pan J., Pandey A.K., Panebianco S., Papikyan V., Pareek P., Park J., Parkkila J.E., Parmar S., Passfeld A., Pathak S.P., Patra R.N., Paul B., Pei H., Peitzmann T., Peng X., Pereira L.G., Pereira Da Costa H., Peresunko D., Perez G.M., Perez Lezama E., Peskov V., Pestov Y., Petracek V., Petrovici M., Pezzi R.P., Piano S., Pikna M., Pillot P., Pimentel L.O.D.L., Pinazza O., Pinsky L., Pisano S., Piyarathna D.B., Ploskon M., Planinic M., Pliquett F., Pluta J., Pochybova S., Poghosyan M.G., Polichtchouk B., Poljak N., Poonsawat W., Pop A., Poppenborg H., Porteboeuf-Houssais S., Pozdniakov V., Prasad S.K., Preghenella R., Prino F., Pruneau C.A., Pshenichnov I., Puccio M., Punin V., Puranapanda K., Putschke J., Quishpe R.E., Ragoni S., Raha S., Rajput S., Rak J., Rakotozafindrabe A., Ramello L., Rami F., Raniwala R., Raniwala S., Rasanen S.S., Rascanu B.T., Rath R., Ratza V., Ravasenga I., Read K.F., Redlich K., Rehman A., Reichelt P., Reidt F., Ren X., Renfordt R., Reshetin A., Revol J.-P., Reygers K., Riabov V., Richert T., Richter M., Riedler P., Riegler W., Riggi F., Ristea C., Rode S.P., Rodriguez Cahuantzi M., Roed K., Rogalev R., Rogochaya E., Rohr D., Rohrich D., Rokita P.S., Ronchetti F., Rosas E.D., Roslon K., Rosnet P., Rossi A., Rotondi A., Roukoutakis F., Roy A., Roy P., Rueda O.V., Rui R., Rumyantsev B., Rustamov A., Ryabinkin E., Ryabov Y., Rybicki A., Rytkonen H., Saarinen S., Sadhu S., Sadovsky S., Safarik K., Saha S.K., Sahoo B., Sahoo P., Sahoo R., Sahoo S., Sahu P.K., Saini J., Sakai S., Sambyal S., Samsonov V., Sandoval A., Sarkar A., Sarkar D., Sarkar N., Sarma P., Sarti V.M., Sas M.H.P., Scapparone E., Schaefer B., Schambach J., Scheid H.S., Schiaua C., Schicker R., Schmah A., Schmidt C., Schmidt H.R., Schmidt M.O., Schmidt M., Schmidt N.V., Schmier A.R., Schukraft J., Schutz Y., Schwarz K., Schweda K., Scioli G., Scomparin E., Sefcik M., Seger J.E., Sekiguchi Y., Sekihata D., Selyuzhenkov I., Senyukov S., Serebryakov D., Serradilla E., Sett P., Sevcenco A., Shabanov A., Shabetai A., Shahoyan R., Shaikh W., Shangaraev A., Sharma A., Sharma M., Sharma N., Sheikh A.I., Shigaki K., Shimomura M., Shirinkin S., Shou Q., Sibiriak Y., Siddhanta S., Siemiarczuk T., Silvermyr D., Silvestre C., Simatovic G., Simonetti G., Singh R., Singh V.K., Singhal V., Sinha T., Sitar B., Sitta M., Skaali T.B., Slupecki M., Smirnov N., Snellings R.J.M., Snellman T.W., Sochan J., Soncco C., Song J., Songmoolnak A., Soramel F., Sorensen S., Sputowska I., Stachel J., Stan I., Stankus P., Steffanic P.J., Stenlund E., Stocco D., Storetvedt M.M., Strmen P., Suaide A.A.P., Sugitate T., Suire C., Suleymanov M., Suljic M., Sultanov R., Sumbera M., Sumowidagdo S., Suzuki K., Swain S., Szabo A., Szarka I., Tabassam U., Taillepied G., Takahashi J., Tambave G.J., Tang S., Tarhini M., Tarzila M.G., Tauro A., Tejeda Munoz G., Telesca A., Terrevoli C., Thakur D., Thakur S., Thomas D., Thoresen F., Tieulent R., Tikhonov A., Timmins A.R., Toia A., Topilskaya N., Toppi M., Torales-Acosta F., Torres S.R., Tripathy S., Tripathy T., Trogolo S., Trombetta G., Tropp L., Trubnikov V., Trzaska W.H., Trzcinski T.P., Trzeciak B.A., Tsuji T., Tumkin A., Turrisi R., Tveter T.S., Ullaland K., Umaka E.N., Uras A., Usai G.L., Utrobicic A., Vala M., Valle N., Vallero S., van der Kolk N., van Doremalen L.V.R., van Leeuwen M., Vande Vyvre P., Varga D., Varga-Kofarago M., Vargas A., Vargyas M., Varma R., Vasileiou M., Vasiliev A., Vazquez Doce O., Vechernin V., Veen A.M., Vercellin E., Vergara Limon S., Vermunt L., Vernet R., Vertesi R., Vicencio M.G.D.L.C., Vickovic L., Viinikainen J., Vilakazi Z., Villalobos Baillie O., Villatoro Tello A., Vino G., Vinogradov A., Virgili T., Vislavicius V., Vodopyanov A., Volkel B., Volkl M.A., Voloshin K., Voloshin S.A., Volpe G., von Haller B., Vorobyev I., Voscek D., Vrlakova J., Wagner B., Watanabe Y., Weber M., Weber S.G., Wegrzynek A., Weiser D.F., Wenzel S.C., Wessels J.P., Widmann E., Wiechula J., Wikne J., Wilk G., Wilkinson J., Willems G.A., Willsher E., Windelband B., Witt W.E., Wu Y., Xu R., Yalcin S., Yamakawa K., Yang S., Yano S., Yin Z., Yokoyama H., Yoo I.-K., Yoon J.H., Yuan S., Yuncu A., Yurchenko V., Zaccolo V., Zaman A., Zampolli C., Zanoli H.J.C., Zardoshti N., Zarochentsev A., Zavada P., Zaviyalov N., Zbroszczyk H., Zhalov M., Zhang X., Zhang Z., Zhao C., Zherebchevskii V., Zhigareva N., Zhou D., Zhou Y., Zhou Z., Zhu J., Zhu Y., Zichichi A., Zimmermann M.B., Zinovjev G., Zurlo N., Helsinki Institute of Physics, Acharya, S., Adamova, D., Adhya, S. 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K., Hadjidakis, C., Hamagaki, H., Hamar, G., Hamid, M., Hannigan, R., Haque, M. R., Harlenderova, A., Harris, J. W., Harton, A., Hasenbichler, J. A., Hassan, H., Hatzifotiadou, D., Hauer, P., Hayashi, S., Heckel, S. T., Hellbar, E., Helstrup, H., Herghelegiu, A., Hernandez, E. G., Herrera Corral, G., Herrmann, F., Hetland, K. F., Hilden, T. E., Hillemanns, H., Hills, C., Hippolyte, B., Hohlweger, B., Horak, D., Hornung, S., Hosokawa, R., Hristov, P., Huang, C., Hughes, C., Huhn, P., Humanic, T. J., Hushnud, H., Husova, L. A., Hussain, N., Hussain, S. A., Hussain, T., Hutter, D., Hwang, D. S., Iddon, J. P., Ilkaev, R., Inaba, M., Ippolitov, M., Islam, M. S., Ivanov, M., Ivanov, V., Izucheev, V., Jacak, B., Jacazio, N., Jacobs, P. M., Jadhav, M. B., Jadlovska, S., Jadlovsky, J., Jaelani, S., Jahnke, C., Jakubowska, M. J., Janik, M. A., Jercic, M., Jevons, O., Jimenez Bustamante, R. T., Jin, M., Jonas, F., Jones, P. G., Jusko, A., Kalinak, P., Kalweit, A., Kang, J. H., Kaplin, V., Kar, S., Karasu Uysal, A., Karavichev, O., Karavicheva, T., Karczmarczyk, P., Karpechev, E., Kebschull, U., Keidel, R., Keil, M., Ketzer, B., Khabanova, Z., Khan, A. M., Khan, S., Khan, S. A., Khanzadeev, A., Kharlov, Y., Khatun, A., Khuntia, A., Kileng, B., Kim, B., Kim, D., Kim, D. J., Kim, E. J., Kim, H., Kim, J., Kim, J. S., Kim, M., Kim, S., Kim, T., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Klay, J. L., Klein, C., Klein, J., Klein, S., Klein-Bosing, C., Klewin, S., Kluge, A., Knichel, M. L., Knospe, A. G., Kobdaj, C., Kohler, M. K., Kollegger, T., Kondratyev, A., Kondratyeva, N., Kondratyuk, E., Konopka, P. J., Koska, L., Kovalenko, O., Kovalenko, V., Kowalski, M., Kralik, I., Kravcakova, A., Kreis, L., Krivda, M., Krizek, F., Krizkova Gajdosova, K., Kruger, M., Kryshen, E., Krzewicki, M., Kubera, A. M., Kucera, V., Kuhn, C., Kuijer, P. G., Kumar, L., Kumar, S., Kundu, S., Kurashvili, P., Kurepin, A., Kurepin, A. B., Kushpil, S., Kvapil, J., Kweon, M. 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B., Ploskon, M., Planinic, M., Pliquett, F., Pluta, J., Pochybova, S., Poghosyan, M. G., Polichtchouk, B., Poljak, N., Poonsawat, W., Pop, A., Poppenborg, H., Porteboeuf-Houssais, S., Pozdniakov, V., Prasad, S. K., Preghenella, R., Prino, F., Pruneau, C. A., Pshenichnov, I., Puccio, M., Punin, V., Puranapanda, K., Putschke, J., Quishpe, R. E., Ragoni, S., Raha, S., Rajput, S., Rak, J., Rakotozafindrabe, A., Ramello, L., Rami, F., Raniwala, R., Raniwala, S., Rasanen, S. S., Rascanu, B. T., Rath, R., Ratza, V., Ravasenga, I., Read, K. F., Redlich, K., Rehman, A., Reichelt, P., Reidt, F., Ren, X., Renfordt, R., Reshetin, A., Revol, J. -P., Reygers, K., Riabov, V., Richert, T., Richter, M., Riedler, P., Riegler, W., Riggi, F., Ristea, C., Rode, S. P., Rodriguez Cahuantzi, M., Roed, K., Rogalev, R., Rogochaya, E., Rohr, D., Rohrich, D., Rokita, P. S., Ronchetti, F., Rosas, E. D., Roslon, K., Rosnet, P., Rossi, A., Rotondi, A., Roukoutakis, F., Roy, A., Roy, P., Rueda, O. V., Rui, R., Rumyantsev, B., Rustamov, A., Ryabinkin, E., Ryabov, Y., Rybicki, A., Rytkonen, H., Saarinen, S., Sadhu, S., Sadovsky, S., Safarik, K., Saha, S. K., Sahoo, B., Sahoo, P., Sahoo, R., Sahoo, S., Sahu, P. K., Saini, J., Sakai, S., Sambyal, S., Samsonov, V., Sandoval, A., Sarkar, A., Sarkar, D., Sarkar, N., Sarma, P., Sarti, V. M., Sas, M. H. P., Scapparone, E., Schaefer, B., Schambach, J., Scheid, H. S., Schiaua, C., Schicker, R., Schmah, A., Schmidt, C., Schmidt, H. R., Schmidt, M. O., Schmidt, M., Schmidt, N. V., Schmier, A. R., Schukraft, J., Schutz, Y., Schwarz, K., Schweda, K., Scioli, G., Scomparin, E., Sefcik, M., Seger, J. E., Sekiguchi, Y., Sekihata, D., Selyuzhenkov, I., Senyukov, S., Serebryakov, D., Serradilla, E., Sett, P., Sevcenco, A., Shabanov, A., Shabetai, A., Shahoyan, R., Shaikh, W., Shangaraev, A., Sharma, A., Sharma, M., Sharma, N., Sheikh, A. 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B., Zinovjev, G., Zurlo, N., Sub Subatomic Physics (SAP), Afd Subatomic Physics (SAP), Subatomic Physics, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
jet substructure, pp and Pb-Pb collisions, heavy ion: scattering, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Physics::Instrumentation and Detectors, Monte Carlo method, Pb-Pb, jet quenchin, jet substructure, heavy-ion collisions, hiukkasfysiikka, pp and Pb-Pb collisions, nucl-ex, pp, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), ALICE, jet, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], color: coherence, Nuclear Experiment (nucl-ex), Nuclear Experiment, Monte Carlo, declustering, Physics, Large Hadron Collider, VDP::Kjerne- og elementærpartikkelfysikk: 431, suppression, lcsh:QC1-999, PRIRODNE ZNANOSTI. Fizika, CERN LHC Coll, Nuclear and elementary particle physics: 431 [VDP], VDP::Nuclear and elementary particle physics: 431, PYTHIA, LHC, pp collisions, Particle Physics - Experiment, Coherence (physics), Nuclear and High Energy Physics, p p: scattering, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 114 Physical sciences, Nuclear physics, heavy-ion, scattering [heavy ion], 0103 physical sciences, ddc:530, Nuclear Physics - Experiment, 010306 general physics, enhancement, 010308 nuclear & particles physics, hep-ex, NATURAL SCIENCES. Physics, 7000 GeV-cms/nucleon 2760 GeV-cms/nucleon, Heavy ion interaction, QGP, Quark–gluon plasma, coherence [color], Substructure, High Energy Physics::Experiment, LHC, jet, QGP, LHC, High-Energy Physics, lcsh:Physics, experimental results
Abstract

The ALICE collaboration at the CERN LHC reports novel measurements of jet substructure in pp collisions at $\sqrt{s}$= 7 TeV and central Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}$ = 2.76 TeV. Jet substructure of track-based jets is explored via iterative declustering and grooming techniques. We present the measurement of the momentum sharing of two-prong substructure exposed via grooming, the $z_{\rm{g}}$, and its dependence on the opening angle, in both pp and Pb-Pb collisions. We also present the first measurement of the distribution of the number of branches obtained in the iterative declustering of the jet, which is interpreted as the number of its hard splittings. In Pb-Pb collisions, we observe a suppression of symmetric splittings at large opening angles and an enhancement of splittings at small opening angles relative to pp collisions, with no significant modification of the number of splittings. The results are compared to predictions from various Monte Carlo event generators to test the role of important concepts in the evolution of the jet in the medium such as color coherence., 20 pages, 4 captioned figures, 3 tables, authors from page 15, published version, figures at http://alice-publications.web.cern.ch/node/5256

Published
2020
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10. A social empowerment intervention to prevent intimate partner violence against women in a microfinance scheme in Tanzania: findings from the MAISHA cluster randomised controlled trial

Author

Charlotte Watts, Grace J Mtolela, Imma Kapinga, Neema Florence Mosha, Shelley Lees, Sheila Harvey, Ramadhan Hashim, Tanya Abramsky, Christian Holm Hansen, Gerry Mshana, Flora Madaha, and Saidi Kapiga

Subjects
medicine.medical_specialty, Sexual Behavior, 030231 tropical medicine, Intimate Partner Violence, Poison control, Tanzania, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intervention (counseling), Injury prevention, medicine, Humans, 030212 general & internal medicine, Cluster randomised controlled trial, Sexual violence, lcsh:Public aspects of medicine, lcsh:RA1-1270, General Medicine, Sexual Partners, Sexual abuse, Family medicine, Domestic violence, Empowerment, Female
Abstract

Summary: Background: Globally, about 30% of women have experienced physical or sexual violence, or both, from an intimate partner during their lifetime. Associations between poverty and women's increased risk of intimate partner violence have been observed. We therefore aimed to assess the effect of a violence prevention intervention delivered to women participating in a group-based microfinance scheme in Tanzania. Methods: We did a cluster randomised controlled trial among women taking part in a microfinance loan scheme in Mwanza city, Tanzania. A microfinance loan group was only enrolled if at least 70% of members consented. We randomly assigned the microfinance groups in blocks of six to receive either the intervention (ie, the intervention arm) or be wait-listed for the intervention after the trial (ie, the control arm). Women in both arms of the trial met weekly for loan repayments. Only those in the intervention arm participated in the ten-session MAISHA intervention that aims to empower women and prevent intimate partner violence. Given the nature of the intervention, it was not possible to mask participants or the research team. The primary outcome was a composite of reported past-year physical or sexual intimate partner violence, or both. Secondary outcome measures were past-year physical, sexual, and emotional intimate partner violence; acceptability and tolerance of intimate partner violence; and attitudes and beliefs related to intimate partner violence. These outcomes were assessed 24 months after the intervention. An intention-to-treat analysis was done, adjusting for age, education, and baseline measure of the respective outcome. The study is registered with ClinicalTrials.gov, number NCT02592252. Findings: Between September, 2014, and June, 2015, 66 (65%) of 101 microfinance groups approached in the study area met the trial eligibility criteria and were enrolled, of which 33 (n=544 women) were allocated to the intervention arm and 33 (n=505 women) to the control arm. Overall, 485 (89%) of 544 women in the intervention arm and 434 (86%) of 505 in the control arm completed the outcomes assessment. Among the intervention arm, 112 (23%) of 485 women reported past-year physical or sexual intimate partner violence, or both, compared with 119 (27%) of 434 in the control arm (adjusted odds ratio [aOR] 0·69, 95% CI 0·47–1·01; p=0·056). Women in the intervention arm were less likely to report physical intimate partner violence (aOR 0·64, 95% CI 0·41–0·99; p=0·043) and were less likely to express attitudes accepting of intimate partner violence (0·45, 0·34–0·61; p

Published
2019

11. Upscaling of Enzymatic Processes

Author

Hans Christian Holm, Per Munk Nielsen, and Fanny Longin

Subjects
0301 basic medicine, 03 medical and health sciences, Biodiesel, 030109 nutrition & dietetics, 0404 agricultural biotechnology, 04 agricultural and veterinary sciences, Biochemical engineering, 040401 food science
Abstract

Since the late 1990s, enzyme use in the oils and fats industry has evolved into state-of-the-art processing. Today, enzymes are used in more than 200 production sites around the world. The key to this wide acceptance of enzymatic processing has been optimization of the enzyme production economy, and especially technology developments on how to apply the enzymes in an efficient way in the different applications to improve yields and product qualities. Up-scaling of these different enzyme processes has predominantly been done in close collaboration between enzyme suppliers and early adopters in the industry, very often in collaboration with engineering companies. This chapter focusses on history and key process learnings from the implementation of enzymes for: production of structured lipids and margarine stock, refining of vegetable oils, production of concentrated omega-3 from fish oils, production of biodiesel from low-quality feedstocks, and production of high-purity cosmetic ingredients. Life-cycle assessments have proved the environmental benefit of enzyme technology compared to chemistry-based routes.

Published
2018
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12. List of Contributors

Author

Casimir C. Akoh, Uwe T. Bornscheuer, Stefan Bruder, Henrike Brundiek, Hanna Büchsenschütz, Xiao Chen, Fang Cong, Jasmina Damnjanović, Elisabeth I.P. Delbeke, Li Deng, Albert J. Dijkstra, Eric Dubreucq, Richard A. Gross, Jens Grüninger, Zheng Guo, Silke Hackenschmidt, Hans Christian Holm, Yugo Iwasaki, Anne-Hélène Jan, Johannes Kabisch, Shigenobu Kishino, Leslie Kleiner, Robert Kourist, Jingbo Li, Lei Li, Fanny Longin, Shekar Mekala, Eva J. Moldenhauer, Per Munk Nielsen, Jun Ogawa, Isabel Oroz-Guinea, Jin-Byung Park, Jacob Nedergaard Pedersen, Anna Schweiger, Sascha Siebenhaller, Chris V. Stevens, Maeva Subileau, Christoph Syldatk, Michiki Takeuchi, Inge N.A. Van Bogaert, Kevin M. Van Geem, Xuebing Xu, Young Joo Yeon, and Katja Zorn

Published
2018
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13. J/ production as a function of charged-particle pseudorapidity density in p–Pb collisions at

Author

Rainer Arno Ernst Renfordt, Andrew Michael Kubera, Petr Nomokonov, David Horak, Rashmi Raniwala, Claude Andre Pruneau, Roberto Barbera, Elena Botta, A. J. Castro, R. A. Negrao De Oliveira, Ana Maria Marin, C. Zhang, V. Grigoriev, Ø. Djuvsland, Z. Yin, Syaefudin Jaelani, M. O. Schmidt, Y. Corrales Morales, Lukas Gruber, Kohei Terasaki, Laura Fabbietti, G. Puddu, Daiki Sekihata, M. Kim, E. Perez Lezama, J.A. Mares, Grazia Luparello, Paraskevi Ganoti, Toralf Bernhard Skaali, M. van Leeuwen, Miroslaw Marek Kielbowicz, Goran Simatovic, Michael Henry Oliver, Dmitry Mal'kevich, G. Martínez García, Herve Borel, P. González-Zamora, Bruno Alessandro, Priyanka Sett, H. Caines, Sudhir Raniwala, Tatiana Karavicheva, Subikash Choudhury, P. L. M. Podesta-Lerma, Gabriele Gaetano Fronze, Ionel Stan, Meike Charlotte Danisch, Rafael Peretti Pezzi, M. Martinez Pedreira, K. Schweda, Marton Vargyas, Andre Mischke, Bharati Naik, M. E. Connors, Y. Pestov, V. Lenti, Pradip Kumar Sahu, Fabrizio Grosa, Ulrich Fuchs, Corrado Gargiulo, Manoj Bhanudas Jadhav, Felix Reidt, V. Chibante Barroso, Linda Vickovic, Yonghong Zhang, Eleazar Cuautle, B. Di Ruzza, Rosario Nania, Paolo Giubellino, Aleksey M. Tikhonov, Raghunath Sahoo, Leo Clifford Greiner, Mohammad Ahmad Saleh, Valerie Ramillien Barret, M. Bombara, Z. Buthelezi, Livio Bianchi, L. Cunqueiro, Serhiy Senyukov, David Dobrigkeit Chinellato, F. Ronchetti, Sumit Kumar Saha, Benjamin Audurier, Erin Frances Gauger, Rosario Turrisi, Manuel Colocci, A. Villatoro Tello, M. A. Diaz Corchero, Mohammad Tariq, E. López Torres, David Olle Rickard Silvermyr, Austin Vincent Harton, Federico Cindolo, Cristina Bedda, Katie Leanne Graham, Oliver Busch, V. Petrov, Premomoy Ghosh, Johann Zmeskal, Lucile Ronflette, Martin Schmidt, Barbara Guerzoni, Peter Christiansen, Evgeny Kondratyuk, A. Kolojvari, Konstantin Mikhaylov, C. J. Schmidt, D. M. Goméz Coral, Andrey Zarochentsev, Anisa Khatun, Iwona Anna Sputowska, Nur Hussain, Jesse Thomas Buxton, T. Peitzmann, G. Boca, Jørgen André Lien, M. Mohisin Khan, Borge Svane Nielsen, Alessandro Ferretti, In-kwon Yoo, William Edward Witt, C. Hadjidakis, C. Alves Garcia Prado, Luciano Musa, Johannes Lehrbach, Sebastian Klewin, Nikita Agrawal, E. Fragiacomo, L. Nellen, Sona Pochybova, Anik Gupta, Ian Gardner Bearden, Bruno Espagnon, Bogdan Theodor Rascanu, M. Masera, Mais Kazim Oglu Suleymanov, Laurent Ducroux, Pragati Sahoo, Zhiqing Zhang, Raphaelle Marie Bailhache, Attiq Ur Rehman, Ki-Seok Choi, Sk Noor Alam, Artem Shangaraev, Piotr Jan Gasik, Vikas Singhal, Antonino Zichichi, Marcelo Gameiro Munhoz, A. A. Vinogradov, A. De Falco, Alexey Kuryakin, Filimon Roukoutakis, Motoi Inaba, Jin Hee Yoon, Valeria Muccifora, Ermanno Vercellin, Lucina Gabriela Espinoza Beltran, Florian Herrmann, Andile Mothegi Whitehead, M. A. Mazzoni, Artem Konevskikh, Tahir Hussain, Catherine Micaela Silvestre, J. Porter, Hao Wang, P. Gianotti, Alessandra Lattuca, Jochen Klein, Audrey Francisco, P. Vande Vyvre, Tuva Ora Herenui Richert, Markus Bernhard Zimmermann, Tsubasa Okubo, Sonia Parmar, E. M. Fiore, Steffen Georg Weber, Ivan Vorobyev, Vladyslav Litichevskyi, Trine Spedstad Tveter, Håvard Helstrup, Vladimir Izucheev, A. G. Bogdanov, Debojit Sarkar, Vladimir Kaplin, Ali Zaman, Liudmila Malinina, Alessandro Grelli, Peter Glassel, R. N. Singaraju, Joel Anthony Mazer, Ivan Kisel, P. Pillot, Ajay Kumar, Ritsuya Hosokawa, Tyler Harrison Lutz, Sanjib Muhuri, P. Roy, Wanchaloem Poonsawat, Vytautas Vislavicius, Christian Holm Christensen, Y. F. Ryabov, Oksana Shadura, Marek Kowalski, S. Li, Y. Watanabe, Friederike Bock, Fedor Guber, Christian Bourjau, Krzysztof Redlich, Boris Batyunya, Francesco Barile, Siegfried Valentin Foertsch, S. K. Basu, Mikhail Malaev, Marco Marquard, Irais Bautista Guzman, J. A. L. Martinez, Zhuo Zhou, Xiao-yan Li, Maria Vasileiou, Xiangrong Zhu, A. M. Rossi, A. Karasu Uysal, Ramona Lea, V. Paticchio, Vladimir Kovalenko, Constantinos Loizides, M. A. Lisa, Gyula Bencedi, Germano Bonomi, Alexander Mamonov, Sami Sakari Rasanen, Ashutosh Pandey, Jubin Mitra, Joakim Nystrand, Hendrik Poppenborg, Stephanie Zimmermann, Jan Jadlovsky, Chengxin Zhao, D. Budnikov, Maitreyee Mukherjee, Silvia Arcelli, P. H. S. Y. Jayarathna, A. Sharma, Muhammad Umair Naru, Andrei Ionut Herghelegiu, Heiko Engel, Jaime Norman, Teodor Siemiarczuk, Chaosong Gao, Saikat Biswas, D. Domenicis Gimenez, J. Pluta, Evgeny Ryabinkin, Martin Poghosyan, J. L. Klay, A. R. Reolon, A. Rustamov, F. R. Grull, Barbara Jacak, Jan Cabala, Marcel Araujo Silva Figueredo, R. Russo, Jung-Il Song, Alexander Philipp Kalweit, L. A. P. Moreno, Christoph Mayer, Dario Berzano, Anju Bhasin, Antonio Uras, Elisa Meninno, U. Frankenfeld, Julien Charles Hamon, A. C. Oliveira Da Silva, Nicola Bianchi, Andrea Alici, Michal Kopcik, S. Sadovsky, Cristina Terrevoli, Paolo Camerini, Benjamin Andreas Hess, Domenico Colella, Martin Andreas Volkl, Vladimir Samsonov, G. A. Feofilov, Gennady Zinovjev, Sergey Voloshin, Sadhana Dash, Sergey Filchagin, Marco Bregant, Lee Stuart Barnby, Piero Giubilato, E. Nappi, Susan L. Swain, Xavier Bernard Lopez, Jaroslav Bielcik, Dai-Mei Zhou, Yves Roland Schutz, Dieter Røhrich, Yongwook Baek, H. Pereira Da Costa, Christine Nattrass, Igor Lakomov, Federica Sozzi, Benjamin Donigus, D. Miśkowiec, Jussi Samuli Viinikainen, Dmitry Finogeev, M. Zhalov, B. Erazmus, Maciej Pawel Szymanski, K. Shtejer, Elena Rogochaya, Helmut Oskar Oeschler, Cristian Andrei, Venelin Anguelov, Eliane Epple, E. Montes, F. Prino, B. Polichtchouk, Sven Gotovac, Zabulon Vilakazi, Roman Lavicka, Peter Zahariev Hristov, Ken Oyama, Igor Pshenichnov, Oliver Werner Arnold, Y. Sekiguchi, Inayat Rasool Bhat, I. Das, Mikolaj Krzewicki, P. I. Loenne, Astrid Vauthier, J. W. Harris, Anton Andronic, A. Rachevski, Sang Un Ahn, G. Tejeda Muñoz, Valentina Zaccolo, Hans Rudolf Schmidt, Ewa Gladysz-dziadus, Jan Rak, Rahul Ramachandran Nair, Jan Figiel, J. Zhu, Arturo Alejandro Menchaca-Rocha, L. Aphecetche, Maciej Slupecki, Rene Bellwied, Raffaele Grosso, Jovan Milosevic, Yu. V. Kharlov, Jan Hladky, Miljenko Suljic, G. S. Pappalardo, P. G. Kuijer, Silvia Masciocchi, Pranjal Sarma, Annika Passfeld, Wladyslaw Henryk Trzaska, Madalina-Gabriela Tarzila, James Declan Mulligan, T. J. Humanic, A. Di Mauro, Shuaib Ahmad Khan, F. Scarlassara, Ernst Hellbar, A. B. Kurepin, Baldo Sahlmuller, Alberto Baldisseri, Andreas Michael Mathis, Prabhat Ranjan Pujahari, Satyajit Jena, Adela Kravcakova, Peter Strmen, Kenta Shigaki, Guido Alexander Willems, A. De Caro, J. Van Der Maarel, P. Di Nezza, Pietro Cortese, K. Šafařík, Preeti Dhankher, Sampo Saarinen, Renaud Vernet, C. Klein-Bösing, Peter Braun-Munzinger, Sanjeev Singh Sambyal, Valeriy Pozdniakov, Nilmoni Sarkar, Vladimir Vechernin, Madan M. Aggarwal, Cristiane Jahnke, A. Nedosekin, Xinye Peng, Ashik Ikbal Sheikh, A. S. Nyanin, F. Bellini, O. Villalobos Baillie, Christian Lippmann, Luis Gustavo Pereira, Giulio Eulisse, Kishora Nayak, J. W. Van Hoorne, R. A. Ricci, Gabor Biro, Naghmeh Mohammadi, V. P. Kondratiev, Kilian Eberhard Schwarz, Andrea Dubla, Alexis Jean-michel Mas, David Michael Rohr, Rajendra Nath Patra, Serpil Yalcin, Wisla Carena, Martino Gagliardi, Nirbhay Kumar Behera, Andrey Vasiliev, Enrico Scomparin, J. Martin Blanco, E. A. R. Casula, R. Varma, D. Di Bari, Susanna Costanza, Edmundo Javier Garcia-Solis, Stefano Piano, E. Calvo Villar, Stefan Kirsch, Sourav Kundu, Sergey Nikulin, Monika Joanna Jakubowska, Kristjan Herlache Gulbrandsen, Dirk Hutter, M. Rodríguez Cahuantzi, Giuseppe Simonetti, M. Irfan, S. U. Chung, Mauro Rogerio Cosentino, S. Esumi, Ralf Keidel, Alice Zimmermann, Pooja Pareek, Lilit Karayan, S. Vergara Limón, Pascal Dillenseger, Janet Elizabeth Seger, Andrea Francescon, Ivan Ravasenga, Peter Levai, Christophe Furget, Bernhard Hohlweger, Jean Willy Andre Cleymans, Volker Lindenstruth, Barbara Antonina Trzeciak, Ranjit Nayak, Bastian Bathen, Vojtech Pacik, Francesco Noferini, Henrik Qvigstad, Dmitry Blau, C. Roy, Ralf Peter Averbeck, S. Beole, C. Lagana Fernandes, S. Mahajan, Prabhakar Palni, Fabio Filippo Colamaria, T. Kollegger, Charalampos Kouzinopoulos, Johannes Peter Wessels, N. Zaviyalov, J. H. Kang, Alexander Borissov, A. Gomez Ramirez, Vardanush Papikyan, R. Alfaro Molina, Annalisa Mastroserio, Jan Fiete Grosse-Oetringhaus, M. Ivanov, M. Keil, R. Scott, M. J. Kweon, D. L. Mihaylov, Kunal Garg, Marielle Chartier, Raimond Snellings, A. J. Rubio Montero, Martin Vala, H. Zhang, Hans Peter Beck, Gergely Gabor Barnafoldi, Michal Broz, C. Petta, Konstantin Munning, J. Wiechula, H. 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Maldonado Cervantes, Elena Bruna, Sonia Rajput, V. Petráček, Ruben Shahoyan, Janka Vrlakova, Tomoya Tsuji, Arseniy Shabanov, Roy Crawford Lemmon, Andrea Festanti, Myunggeun Song, W. J. Llope, Lucia Leardini, Jurgen Schukraft, Satyabrata Kar, Victor Trubnikov, Julien Faivre, Jana Bielcikova, Hiroshi Murakami, Klaus Johannes Reygers, Astrid Morreale, Xiaowen Ren, Dominik Voscek, L. Lazaridis, Robert Vertesi, F. Carnesecchi, Antoine Xavier Lardeux, Bjarte Kileng, M. An, Rama Chandra Baral, Ganesh Jagannath Tambave, Jin-Hong Park, Nikola Poljak, Torsten Dahms, Henner Buesching, Erik Brücken, Peter Graham Jones, S. L. La Pointe, David H. Evans, I. Cortés Maldonado, Smbat Grigoryan, Diego Stocco, Rainer Martin Schicker, J. de Cuveland, Massimiliano Marchisone, Deepa Thomas, Eric Endress, Stefan Thomas Heckel, P. Rosnet, Andrey Reshetin, Sukalyan Chattopadhyay, Marcello Lunardon, J. Saini, Amalia Pop, Rachid Guernane, Chitrasen Jena, Imrich Szarka, Andrzej Deloff, Nicole Bastid, Ankhi Roy, J. Book, Latchezar Betev, Andre Augustinus, J. J. Gaardhøje, Hongbo Zhu, Redmer Alexander Bertens, Marie Germain, Bedangadas Mohanty, Sebastian Rosado Navarro, Fatiha Lehas, Alice Elisabeth Ohlson, Marcello Borri, Alexander Vodopyanov, H. Natal da Luz, Alexandr Tumkin, Rafay Anwar, E. G. Ferreiro, Ashpreet Kaur Duggal, Sushanta Tripathy, Adrian Sevcenco, Stefano Panebianco, Fabian Ng, Hermann Franz Degenhardt, Dennis Franz Weiser, H. J. C. Zanoli, Evgeny Kryshen, Vladimir V. Isakov, Roberto Preghenella, Marek Chojnacki, and E. Serradilla

Subjects
Physics, Nuclear and High Energy Physics, Large Hadron Collider, 010308 nuclear & particles physics, Monte Carlo method, Observable, Multiplicity (mathematics), 01 natural sciences, Charged particle, Nuclear physics, Pseudorapidity, 0103 physical sciences, Transverse momentum, Rapidity, Nuclear Experiment, 010306 general physics
Abstract

We report measurements of the inclusive J/ψ yield and average transverse momentum as a function of charged-particle pseudorapidity density dNch/dη in p–Pb collisions at sNN=5.02TeV with ALICE at the LHC. The observables are normalised to their corresponding averages in non-single diffractive events. An increase of the normalised J/ψ yield with normalised dNch/dη, measured at mid-rapidity, is observed at mid-rapidity and backward rapidity. At forward rapidity, a saturation of the relative yield is observed for high charged-particle multiplicities. The normalised average transverse momentum at forward and backward rapidities increases with multiplicity at low multiplicities and saturates beyond moderate multiplicities. In addition, the forward-to-backward nuclear modification factor ratio is also reported, showing an increasing suppression of J/ψ production at forward rapidity with respect to backward rapidity for increasing charged-particle multiplicity.

Published
2017

14. Centrality dependence of the pseudorapidity density distribution for charged particles in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV

Author

Abbas, Ehab, Abelev, Betty, Adam, Jaroslav, Adamova, Dagmar, Adare, Andrew Marshall, Aggarwal, Madan, Aglieri Rinella, Gianluca, Agnello, Michelangelo, Agocs, Andras Gabor, Agostinelli, Andrea, Ahammed, Zubayer, Ahmad, Arshad, Ahmad, Nazeer, Ahn, Sang Un, Ahn, Sul-Ah, Aimo, Ilaria, Ajaz, Muhammad, Akindinov, Alexander, Aleksandrov, Dmitry, Alessandro, Bruno, Alici, Andrea, Alkin, Anton, Almaraz Avina, Erick Jonathan, Alme, Johan, Alt, Torsten, Altini, Valerio, Altinpinar, Sedat, Altsybeev, Igor, Andrei, Cristian, Andronic, Anton, Anguelov, Venelin, Anielski, Jonas, Anson, Christopher Daniel, Anticic, Tome, Antinori, Federico, Antonioli, Pietro, Aphecetche, Laurent Bernard, Appelshauser, Harald, Arbor, Nicolas, Arcelli, Silvia, Arend, Andreas, Armesto, Nestor, Arnaldi, Roberta, Aronsson, Tomas Robert, Arsene, Ionut Cristian, Arslandok, Mesut, Asryan, Andzhey, Augustinus, Andre, Averbeck, Ralf Peter, Awes, Terry, Aysto, Juha Heikki, Azmi, Mohd Danish, Bach, Matthias Jakob, Badala, Angela, Baek, Yong Wook, Bailhache, Raphaelle Marie, Bala, Renu, Baldisseri, Alberto, Baltasar Dos Santos Pedrosa, Fernando, Ban, Jaroslav, Baral, Rama Chandra, Barbera, Roberto, Barile, Francesco, Barnafoldi, Gergely Gabor, Barnby, Lee Stuart, Barret, Valerie, Bartke, Jerzy Gustaw, Basile, Maurizio, Bastid, Nicole, Basu, Sumit, Bathen, Bastian, Batigne, Guillaume, Batyunya, Boris, Batzing, Paul Christoph, Baumann, Christoph Heinrich, Bearden, Ian Gardner, Beck, Hans, Behera, Nirbhay Kumar, Belikov, Iouri, Bellini, Francesca, Bellwied, Rene, Belmont-Moreno, Ernesto, Bencedi, Gyula, Beole, Stefania, Berceanu, Ionela, Bercuci, Alexandru, Berdnikov, Yaroslav, Berenyi, Daniel, Bergognon, Anais Annick Erica, Bertens, Redmer Alexander, Berzano, Dario, Betev, Latchezar, Bhasin, Anju, Bhati, Ashok Kumar, Bhom, Jihyun, Bianchi, Nicola, Bianchi, Livio, Bianchin, Chiara, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Bjelogrlic, Sandro, Blanco, F, Blanco, Francescorancesco, Blau, Dmitry, 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Kazantsev, Andrey, Kebschull, Udo Wolfgang, Keidel, Ralf, Ketzer, Bernhard Franz, Khan, Kamal Hussain, Khan, Mohisin Mohammed, Khan, Palash, Khan, Shuaib Ahmad, Khanzadeev, Alexei, Kharlov, Yury, Kileng, Bjarte, Kim, Minwoo, Kim, Se Yong, Kim, Beomkyu, Kim, Taesoo, Kim, Dong Jo, Kim, Do Won, Kim, Jonghyun, Kim, Jin Sook, Kim, Mimae, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam Ryszard, Klay, Jennifer Lynn, Klein, Jochen, Klein-Bosing, Christian, Kliemant, Michael, Kluge, Alexander, Knichel, Michael Linus, Knospe, Anders Garritt, Kohler, Markus, Kollegger, Thorsten, Kolojvari, Anatoly, Kompaniets, Mikhail, Kondratiev, Valery, Kondratyeva, Natalia, Konevskih, Artem, Kovalenko, Vladimir, Kowalski, Marek, Kox, Serge, Koyithatta Meethaleveedu, Greeshma, Kral, Jiri, Kralik, Ivan, Kramer, Frederick, Kravcakova, Adela, Krelina, Michal, Kretz, Matthias, Krivda, Marian, Krizek, Filip, Krus, Miroslav, Kryshen, Evgeny, Krzewicki, Mikolaj, Kucera, Vit, Kucheriaev, Yury, Kugathasan, Thanushan, Kuhn, Christian Claude, Kuijer, Paul, Kulakov, Igor, Kumar, Jitendra, Kurashvili, Podist, Kurepin, A, Kurepin, AB, Kuryakin, Alexey, Kushpil, Svetlana, Kushpil, Vasily, Kvaerno, Henning, Kweon, Min Jung, Kwon, Youngil, Ladron de Guevara, Pedro, Lakomov, Igor, Langoy, Rune, La Pointe, Sarah Louise, Lara, Camilo Ernesto, Lardeux, Antoine Xavier, La Rocca, Paola, Lea, Ramona, Lechman, Mateusz, Lee, Sung Chul, Lee, Graham Richard, Legrand, Iosif, Lehnert, Joerg Walter, Lemmon, Roy Crawford, Lenhardt, Matthieu Laurent, Lenti, Vito, Leon, Hermes, Leoncino, Marco, Leon Monzon, Ildefonso, Levai, Peter, Li, Shuang, Lien, Jorgen, Lietava, Roman, Lindal, Svein, Lindenstruth, Volker, Lippmann, Christian, Lisa, Michael Annan, Ljunggren, Hans Martin, Lodato, Davide Francesco, Loenne, Per-Ivar, Loggins, Vera, Loginov, Vitaly, Lohner, Daniel, Loizides, Constantinos, Loo, Kai Krister, Lopez, Xavier Bernard, Lopez Torres, Ernesto, Lovhoiden, Gunnar, Lu, Xianguo, Luettig, Philipp, Lunardon, 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Yasuo, Mikhaylov, Konstantin, Milano, Leonardo, Milosevic, Jovan, Mischke, Andre, Mishra, Aditya Nath, Miskowiec, Dariusz, Mitu, Ciprian Mihai, Mizuno, Sanshiro, Mlynarz, Jocelyn, Mohanty, Bedangadas, Molnar, Levente, Montano Zetina, Luis Manuel, Monteno, Marco, Montes, Esther, Moon, Taebong, Morando, Maurizio, Moreira De Godoy, Denise Aparecida, Moretto, Sandra, Morreale, Astrid, Morsch, Andreas, Muccifora, Valeria, Mudnic, Eugen, Muhuri, Sanjib, Mukherjee, Maitreyee, Muller, Hans, Munhoz, Marcelo, Murray, Sean, Musa, Luciano, Musinsky, Jan, Nandi, Basanta Kumar, Nania, Rosario, Nappi, Eugenio, Nattrass, Christine, Nayak, Tapan Kumar, Nazarenko, Sergey, Nedosekin, Alexander, Nicassio, Maria, Niculescu, Mihai, Nielsen, Borge Svane, Niida, Takafumi, Nikolaev, Sergey, Nikolic, Vedran, Nikulin, Sergey, Nikulin, Vladimir, Nilsen, Bjorn Steven, Nilsson, Mads Stormo, Noferini, Francesco, Nomokonov, Petr, Nooren, Gerardus, Nyanin, Alexandre, Nyatha, Anitha, Nygaard, Casper, Nystrand, Joakim Ingemar, Ochirov, Alexander, Oeschler, Helmut Oskar, Oh, Saehanseul, Oh, Sun Kun, Oleniacz, Janusz, Oliveira Da Silva, Antonio Carlos, Oppedisano, Chiara, Ortiz Velasquez, Antonio, Oskarsson, Anders Nils Erik, Ostrowski, Piotr Krystian, Otwinowski, Jacek Tomasz, Oyama, Ken, Ozawa, Kyoichiro, Pachmayer, Yvonne Chiara, Pachr, Milos, Padilla, Fatima, Pagano, Paola, Paic, Guy, Painke, Florian, Pajares, Carlos, Pal, Susanta Kumar, Palaha, Arvinder Singh, Palmeri, Armando, Papikyan, Vardanush, Pappalardo, Giuseppe, Park, Woo Jin, Passfeld, Annika, Patalakha, Dmitri Ivanovich, Paticchio, Vincenzo, Paul, Biswarup, Pavlinov, Alexei, Pawlak, Tomasz Jan, Peitzmann, Thomas, Pereira Da Costa, Hugo Denis Antonio, Pereira De Oliveira Filho, Elienos, Peresunko, Dmitri, Perez Lara, Carlos Eugenio, Perrino, Davide, Peryt, Wiktor Stanislaw, Pesci, Alessandro, Pestov, Yury, Petracek, Vojtech, Petran, Michal, Petris, Mariana, Petrov, Plamen Rumenov, Petrovici, Mihai, Petta, Catia, Piano, Stefano, Pikna, Miroslav, Pillot, Philippe, Pinazza, Ombretta, Pinsky, Lawrence, Pitz, Nora, Piyarathna, Danthasinghe, Planinic, Mirko, Ploskon, Mateusz Andrzej, Pluta, Jan Marian, Pocheptsov, Timur, Pochybova, Sona, Podesta Lerma, Pedro Luis Manuel, Poghosyan, Martin, Polak, Karel, Polichtchouk, Boris, Poljak, Nikola, Pop, Amalia, Porteboeuf-Houssais, Sarah, Pospisil, Vladimir, Potukuchi, Baba, Prasad, Sidharth Kumar, Preghenella, Roberto, Prino, Francesco, Pruneau, Claude Andre, Pshenichnov, Igor, Puddu, Giovanna, Punin, Valery, Putis, Marian, Putschke, Jorn Henning, Qvigstad, Henrik, Rachevski, Alexandre, Rademakers, Alphonse, Raiha, Tomi Samuli, Rak, Jan, Rakotozafindrabe, Andry Malala, Ramello, Luciano, Raniwala, Sudhir, Raniwala, Rashmi, Rasanen, Sami Sakari, Rascanu, Bogdan Theodor, Rathee, Deepika, Rauch, Wolfgang, Read, Kenneth Francis, Real, Jean-Sebastien, Redlich, Krzysztof, Reed, Rosi Jan, Rehman, Attiq Ur, Reichelt, Patrick, Reicher, Martijn, Renfordt, Rainer Arno Ernst, Reolon, Anna 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Rolf Paul, Schiaua, Claudiu Cornel, Schicker, Rainer Martin, Schmidt, Hans Rudolf, Schmidt, Christian Joachim, Schuchmann, Simone, Schukraft, Jurgen, Schuster, Tim, Schutz, Yves Roland, Schwarz, Kilian Eberhard, Schweda, Kai Oliver, Scioli, Gilda, Scomparin, Enrico, Scott, Rebecca, Scott, Patrick Aaron, Segato, Gianfranco, Selyuzhenkov, Ilya, Senyukov, Serhiy, Seo, Jeewon, Serci, Sergio, Serradilla, Eulogio, Sevcenco, Adrian, Shabetai, Alexandre, Shabratova, Galina, Shahoyan, Ruben, Sharma, Natasha, Sharma, Satish, Sharma, Rohni, Shigaki, Kenta, Shtejer, Katherin, Sibiriak, Yury, Sicking, Eva, Siddhanta, Sabyasachi, Siemiarczuk, Teodor, Silvermyr, David Olle Rickard, Silvestre, Catherine, Simatovic, Goran, Simonetti, Giuseppe, Singaraju, Rama Narayana, Singh, Ranbir, Singha, Subhash, Singhal, Vikas, Sinha, Bikash, Sinha, Tinku, Sitar, Branislav, Sitta, Mario, Skaali, Bernhard, Skjerdal, Kyrre, Smakal, Radek, Smirnov, Nikolai, Snellings, Raimond, Sogaard, Carsten, Soltz, Ron Ariel, Song, Myunggeun, Song, Jihye, Soos, Csaba, Soramel, Francesca, Sputowska, Iwona, Spyropoulou-Stassinaki, Martha, Srivastava, Brijesh Kumar, Stachel, Johanna, Stan, Ionel, Stefanek, Grzegorz, Steinpreis, Matthew, Stenlund, Evert Anders, Steyn, Gideon Francois, Stiller, Johannes Hendrik, Stocco, Diego, Stolpovskiy, Mikhail, Strmen, Peter, Suaide, Alexandre Alarcon do Passo, Subieta Vasquez, Martin Alfonso, Sugitate, Toru, Suire, Christophe Pierre, Sultanov, Rishat, Sumbera, Michal, Susa, Tatjana, Symons, Timothy, Szanto de Toledo, Alejandro, Szarka, Imrich, Szczepankiewicz, Adam, Szymanski, Maciej, Takahashi, Jun, Tangaro, Marco-Antonio, Tapia Takaki, Daniel Jesus, Tarantola Peloni, Attilio, Tarazona Martinez, Alfonso, Tauro, Arturo, Tejeda Munoz, Guillermo, Telesca, Adriana, Ter-Minasyan, Astkhik, Terrevoli, Cristina, Thader, Jochen Mathias, Thomas, Deepa, Tieulent, Raphael Noel, Timmins, Anthony, Tlusty, David, Toia, Alberica, Torii, Hisayuki, Toscano, Luca, Trubnikov, Victor, Truesdale, David Christopher, Trzaska, Wladyslaw Henryk, Tsuji, Tomoya, Tumkin, Alexandr, Turrisi, Rosario, Tveter, Trine Spedstad, Ulery, Jason Glyndwr, Ullaland, Kjetil, Ulrich, Jochen, Uras, Antonio, Urciuoli, Guido Marie, Usai, Gianluca, Vajzer, Michal, Vala, Martin, Valencia Palomo, Lizardo, Vande Vyvre, Pierre, Van Hoorne, Jacobus Willem, van Leeuwen, Marco, Vannucci, Luigi, Vargas, Aurora Diozcora, Varma, Raghava, Vasileiou, Maria, Vasiliev, Andrey, Vechernin, Vladimir, Veldhoen, Misha, Venaruzzo, Massimo, Vercellin, Ermanno, Vergara, Sergio, Vernet, Renaud, Verweij, Marta, Vickovic, Linda, Viesti, Giuseppe, Viinikainen, Jussi, Vilakazi, Zabulon, Villalobos Baillie, Orlando, Vinogradov, Yury, Vinogradov, Leonid, Vinogradov, Alexander, Virgili, Tiziano, Viyogi, Yogendra, Vodopianov, Alexander, Volkl, Martin Andreas, Voloshin, Sergey, Voloshin, Kirill, Volpe, Giacomo, von Haller, Barthelemy, Vorobyev, Ivan, Vranic, Danilo, Vrlakova, Janka, Vulpescu, Bogdan, Vyushin, Alexey, Wagner, Boris, Wagner, Vladimir, Wan, Renzhuo, Wang, Yaping, Wang, Mengliang, Wang, Yifei, Watanabe, Kengo, Weber, Michael, Wessels, Johannes, Westerhoff, Uwe, Wiechula, Jens, Wikne, Jon, Wilde, Martin Rudolf, Wilk, Grzegorz Andrzej, Williams, Crispin, Windelband, Bernd Stefan, Xaplanteris Karampatsos, Leonidas, Yaldo, Chris G, Yamaguchi, Yorito, Yang, Shiming, Yang, Ping, Yang, Hongyan, Yasnopolsky, Stanislav, Yi, JunGyu, Yin, Zhongbao, Yoo, In-Kwon, Yoon, Jongik, Yu, Weilin, Yuan, Xianbao, Yushmanov, Igor, Zaccolo, Valentina, Zach, Cenek, Zampolli, Chiara, Zaporozhets, Sergey, Zarochentsev, Andrey, Zavada, Petr, Zaviyalov, Nikolai, Zbroszczyk, Hanna Paulina, Zelnicek, Pierre, Zgura, Sorin Ion, Zhalov, Mikhail, Zhang, Haitao, Zhang, Xiaoming, Zhang, Yonghong, Zhou, Daicui, Zhou, Fengchu, Zhou, You, Zhu, Hongsheng, Zhu, Jianlin, Zhu, Xiangrong, Zhu, Jianhui, Zichichi, Antonino, Zimmermann, Alice, Zinovjev, Gennady, Zoccarato, Yannick Denis, Zynovyev, Mykhaylo, Zyzak, Maksym, UNIVERSIDADE DE ESTADUAL DE CAMPINAS, Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALICE, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Heavy-ion collisions, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Matematikk og naturvitenskap: 400::Fysikk: 430::Kjerne- og elementærpartikkelfysikk: 431 [VDP], FOS: Physical sciences, Charged-particle density, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Mathematics and natural scienses: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Nuclear and elementary particle physics: 431 [VDP], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Wide rapidity coverage, Nuclear Physics - Experiment, LHC, Nuclear Experiment (nucl-ex), Nuclear Experiment, Heavy ions collisions, charged-particle density, Particle Physics - Experiment
Abstract

We present the first wide-range measurement of the charged-particle pseudorapidity density distribution, for different centralities (the 0-5%, 5-10%, 10-20%, and 20-30% most central events) in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV at the LHC. The measurement is performed using the full coverage of the ALICE detectors, $-5.0 < ��< 5.5$, and employing a special analysis technique based on collisions arising from LHC "satellite" bunches. We present the pseudorapidity density as a function of the number of participating nucleons as well as an extrapolation to the total number of produced charged particles ($N_{\rm ch} = 17165 \pm 772$ for the 0-5% most central collisions). From the measured ${\rm d}N_{\rm ch}/{\rm d}��$ distribution we derive the rapidity density distribution, ${\rm d}N_{\rm ch}/{\rm d}y$, under simple assumptions. The rapidity density distribution is found to be significantly wider than the predictions of the Landau model. We assess the validity of longitudinal scaling by comparing to lower energy results from RHIC. Finally the mechanisms of the underlying particle production are discussed based on a comparison with various theoretical models., 21 pages, 9 captioned figures, 2 tables, authors from page 16, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/592

Published
2016
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16. Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at $\sqrt{s_{\rm NN}}=2.76$ TeV

Author

Abelev, Betty, Adam, Jaroslav, Adamova, Dagmar, Adare, Andrew Marshall, Aggarwal, Madan, Aglieri Rinella, Gianluca, Agocs, Andras Gabor, Agostinelli, Andrea, Aguilar Salazar, Saul, Ahammed, Zubayer, Ahmad, Arshad, Ahmad, Nazeer, Ahn, Sang Un, Akindinov, Alexander, Aleksandrov, Dmitry, Alessandro, Bruno, Alfaro Molina, Jose Ruben, Alici, Andrea, Alkin, Anton, Almaraz Avina, Erick Jonathan, Alme, Johan, Alt, Torsten, Altini, Valerio, Altinpinar, Sedat, Altsybeev, Igor, Andrei, Cristian, Andronic, Anton, Anguelov, Venelin, Anielski, Jonas, Anticic, Tome, Antinori, Federico, Antonioli, Pietro, Aphecetche, Laurent Bernard, Appelshauser, Harald, Arbor, Nicolas, Arcelli, Silvia, Armesto, Nestor, Arnaldi, Roberta, Aronsson, Tomas Robert, Arsene, Ionut Cristian, Arslandok, Mesut, Augustinus, Andre, Averbeck, Ralf Peter, Awes, Terry, Aysto, Juha Heikki, Azmi, Mohd Danish, Bach, Matthias Jakob, Badala, Angela, Baek, Yong Wook, Bailhache, Raphaelle Marie, Bala, Renu, Baldini Ferroli, Rinaldo, Baldisseri, Alberto, Baldit, Alain, Baltasar Dos Santos Pedrosa, Fernando, Ban, Jaroslav, Baral, Rama Chandra, Barbera, Roberto, Barile, Francesco, Barnafoldi, Gergely Gabor, Barnby, Lee Stuart, Barret, Valerie, Bartke, Jerzy Gustaw, Basile, Maurizio, Bastid, Nicole, Basu, Sumit, Bathen, Bastian, Batigne, Guillaume, Batyunya, Boris, Baumann, Christoph Heinrich, Bearden, Ian Gardner, Beck, Hans, Behera, Nirbhay Kumar, Belikov, Iouri, Bellini, Francesca, Bellwied, Rene, Belmont-Moreno, Ernesto, Bencedi, Gyula, Beole, Stefania, Berceanu, Ionela, Bercuci, Alexandru, Berdnikov, Yaroslav, Berenyi, Daniel, Bergognon, Anais Annick Erica, Berzano, Dario, Betev, Latchezar, Bhasin, Anju, Bhati, Ashok Kumar, Bhom, Jihyun, Bianchi, Livio, Bianchi, Nicola, Bianchin, Chiara, Bielcik, Jaroslav, Bielcikova, Jana, Bilandzic, Ante, Bjelogrlic, Sandro, Blanco, F, Blanco, Francescorancesco, Blau, Dmitry, Blume, Christoph, Bock, Nicolas, Boettger, Stefan, Bogdanov, Alexey, Boggild, Hans, Bogolyubsky, Mikhail, Boldizsar, Laszlo, Bombara, Marek, Book, Julian, Borel, Herve, Borissov, Alexander, Bose, Suvendu Nath, Bossu, Francesco, Botje, Michiel, Boyer, Bruno Alexandre, Braidot, Ermes, Braun-Munzinger, Peter, Bregant, Marco, Breitner, Timo Gunther, Browning, Tyler Allen, Broz, Michal, Brun, Rene, Bruna, Elena, Bruno, Giuseppe Eugenio, Budnikov, Dmitry, Buesching, Henner, Bufalino, Stefania, Bugaiev, Kyrylo, Busch, Oliver, Buthelezi, Edith Zinhle, Caffarri, Davide, Cai, Xu, Caines, Helen Louise, Calvo Villar, Ernesto, Camerini, Paolo, Canoa Roman, Veronica, Cara Romeo, Giovanni, Carena, Francesco, Carena, Wisla, Carminati, Federico, Casanova Diaz, Amaya Ofelia, Castillo Castellanos, Javier Ernesto, Casula, Ester Anna Rita, Catanescu, Vasile, Cavicchioli, Costanza, Ceballos Sanchez, Cesar, Cepila, Jan, Cerello, Piergiorgio, Chang, Beomsu, Chapeland, Sylvain, Charvet, Jean-Luc Fernand, Chattopadhyay, Sukalyan, Chattopadhyay, Subhasis, Chawla, Isha, Cherney, Michael Gerard, Cheshkov, Cvetan, Cheynis, Brigitte, Chiavassa, Emilio, Chibante Barroso, Vasco Miguel, Chinellato, David, Chochula, Peter, Chojnacki, Marek, Choudhury, Subikash, Christakoglou, Panagiotis, Christensen, Christian Holm, Christiansen, Peter, Chujo, Tatsuya, Chung, Suh-Urk, Cicalo, Corrado, Cifarelli, Luisa, Cindolo, Federico, Cleymans, Jean Willy Andre, Coccetti, Fabrizio, Colamaria, Fabio, Colella, Domenico, Conesa Balbastre, Gustavo, Conesa del Valle, Zaida, Constantin, Paul, Contin, Giacomo, Contreras, Jesus Guillermo, Cormier, Thomas Michael, Corrales Morales, Yasser, Cortes Maldonado, Ismael, Cortese, Pietro, Cosentino, Mauro Rogerio, Costa, Filippo, Cotallo, Manuel Enrique, Crochet, Philippe, Cruz Alaniz, Emilia, Cuautle, Eleazar, Cunqueiro, Leticia, D'Erasmo, Ginevra, Dainese, Andrea, Dalsgaard, Hans Hjersing, Danu, Andrea, Das, Debasish, Das, Indranil, Das, Kushal, Dash, Ajay Kumar, Dash, Sadhana, De, Sudipan, de Barros, Gabriel, De Caro, Annalisa, de Cataldo, Giacinto, de Cuveland, Jan, De Falco, Alessandro, De Gruttola, Daniele, De Marco, Nora, De Pasquale, Salvatore, de Rooij, Raoul Stefan, Delagrange, Hugues, Deloff, Andrzej, Demanov, Vyacheslav, Denes, Ervin, Deppman, Airton, Di Bari, Domenico, Di Giglio, Carmelo, Di Liberto, Sergio, Di Mauro, Antonio, Di Nezza, Pasquale, Diaz Corchero, Miguel Angel, Dietel, Thomas, Divia, Roberto, Djuvsland, Oeystein, Dobrin, Alexandru Florin, Dobrowolski, Tadeusz Antoni, Dominguez, Isabel, Donigus, Benjamin, Dordic, Olja, Driga, Olga, Dubey, Anand Kumar, Ducroux, Laurent, Dupieux, Pascal, Dutta Majumdar, AK, Dutta Majumdar, Mihir Ranjan, Elia, Domenico, Emschermann, David Philip, Engel, Heiko, Erdal, Hege Austrheim, Espagnon, Bruno, Estienne, Magali Danielle, Esumi, Shinichi, Evans, David, Eyyubova, Gyulnara, Fabris, Daniela, Faivre, Julien, Falchieri, Davide, Fantoni, Alessandra, Fasel, Markus, Fearick, Roger Worsley, Fedunov, Anatoly, Fehlker, Dominik, Feldkamp, Linus, Felea, Daniel, Fenton-Olsen, Bo, Feofilov, Grigory, Fernandez Tellez, Arturo, Ferretti, Alessandro, Ferretti, Roberta, Figiel, Jan, Figueredo, Marcel, Filchagin, Sergey, Finogeev, Dmitry, Fionda, Fiorella, Fiore, Enrichetta Maria, Floris, Michele, Foertsch, Siegfried Valentin, Foka, Panagiota, Fokin, Sergey, Fragiacomo, Enrico, Frankenfeld, Ulrich Michael, Fuchs, Ulrich, Furget, Christophe, Fusco Girard, Mario, Gaardhoje, Jens Joergen, Gagliardi, Martino, Gago, Alberto, Gallio, Mauro, Gangadharan, Dhevan Raja, Ganoti, Paraskevi, Garabatos, Jose, Garcia-Solis, Edmundo, Garishvili, Irakli, Gerhard, Jochen, Germain, Marie, Geuna, Claudio, Gheata, Andrei George, Gheata, Mihaela, Ghidini, Bruno, Ghosh, Premomoy, Gianotti, Paola, Girard, Martin Robert, Giubellino, Paolo, Gladysz-Dziadus, Ewa, Glassel, Peter, Gomez, Ramon, Gonschior, Alexey, Gonzalez Ferreiro, Elena, Gonzalez-Trueba, Laura Helena, Gonzalez-Zamora, Pedro, Gorbunov, Sergey, Goswami, Ankita, Gotovac, Sven, Grabski, Varlen, Graczykowski, Lukasz Kamil, Grajcarek, Robert, Grelli, Alessandro, Grigoras, Alina Gabriela, Grigoras, Costin, Grigoriev, Vladislav, Grigoryan, Ara, Grigoryan, Smbat, Grinyov, Boris, Grion, Nevio, Grosse-Oetringhaus, Jan Fiete, Grossiord, Jean-Yves, Grosso, Raffaele, Guber, Fedor, Guernane, Rachid, Guerra Gutierrez, Cesar, Guerzoni, Barbara, Guilbaud, Maxime Rene Joseph, Gulbrandsen, Kristjan Herlache, Gunji, Taku, Gupta, Anik, Gupta, Ramni, Gutbrod, Hans, Haaland, Oystein Senneset, Hadjidakis, Cynthia Marie, Haiduc, Maria, Hamagaki, Hideki, Hamar, Gergoe, Hanratty, Luke David, Hansen, Alexander, Harmanova, Zuzana, Harris, John William, Hartig, Matthias, Hasegan, Dumitru, Hatzifotiadou, Despoina, Hayrapetyan, Arsen, Heckel, Stefan Thomas, Heide, Markus Ansgar, Helstrup, Haavard, Herghelegiu, Andrei Ionut, Herrera Corral, Gerardo Antonio, Herrmann, Norbert, Hess, Benjamin Andreas, Hetland, Kristin Fanebust, Hicks, Bernard, Hille, Per Thomas, Hippolyte, Boris, Horaguchi, Takuma, Hori, Yasuto, Hristov, Peter Zahariev, Hrivnacova, Ivana, Huang, Meidana, Humanic, Thomas, Hwang, Dae Sung, Ichou, Raphaelle, Ilkaev, Radiy, Ilkiv, Iryna, Inaba, Motoi, Incani, Elisa, Innocenti, Gian Michele, Ippolitov, Mikhail, Irfan, Muhammad, Ivan, Cristian George, Ivanov, Andrey, Ivanov, Marian, Ivanov, Vladimir, Ivanytskyi, Oleksii, Jacholkowski, Adam Wlodzimierz, Jacobs, Peter, Jangal, Swensy Gwladys, Janik, Malgorzata Anna, Janik, Rudolf, Jayarathna, Sandun, Jena, Satyajit, Jha, Deeptanshu Manu, Jimenez Bustamante, Raul Tonatiuh, Jirden, Lennart, Jones, Peter Graham, Jung, Hyung Taik, Jusko, Anton, Kakoyan, Vanik, Kalcher, Sebastian, Kalinak, Peter, Kalliokoski, Tuomo Esa Aukusti, Kalweit, Alexander Philipp, Kanaki, Kalliopi, Kang, Ju Hwan, Kaplin, Vladimir, Karasu Uysal, Ayben, Karavichev, Oleg, Karavicheva, Tatiana, Karpechev, Evgeny, Kazantsev, Andrey, Kebschull, Udo Wolfgang, Keidel, Ralf, Khan, Mohisin Mohammed, Khan, Palash, Khan, Shuaib Ahmad, Khanzadeev, Alexei, Kharlov, Yury, Kileng, Bjarte, Kim, Beomkyu, Kim, Dong Jo, Kim, Do Won, Kim, Jonghyun, Kim, Jin Sook, Kim, Minwoo, Kim, Mimae, Kim, Se Yong, Kim, Seon Hee, Kim, Taesoo, Kirsch, Stefan, Kisel, Ivan, Kiselev, Sergey, Kisiel, Adam Ryszard, Klay, Jennifer Lynn, Klein, Jochen, Klein-Bosing, Christian, Kluge, Alexander, Knichel, Michael Linus, Knospe, Anders Garritt, Koch, Kathrin, Kohler, Markus, Kolojvari, Anatoly, Kondratiev, Valery, Kondratyeva, Natalia, Konevskih, Artem, Korneev, Andrey, Kour, Ravjeet, Kowalski, Marek, Kox, Serge, Koyithatta Meethaleveedu, Greeshma, Kral, Jiri, Kralik, Ivan, Kramer, Frederick, Kraus, Ingrid Christine, Krawutschke, Tobias, Krelina, Michal, Kretz, Matthias, Krivda, Marian, Krizek, Filip, Krus, Miroslav, Kryshen, Evgeny, Krzewicki, Mikolaj, Kucheriaev, Yury, Kuhn, Christian Claude, Kuijer, Paul, Kulakov, Igor, Kurashvili, Podist, Kurepin, A, Kurepin, AB, Kuryakin, Alexey, Kushpil, Svetlana, Kushpil, Vasily, Kweon, Min Jung, Kwon, Youngil, La Pointe, Sarah Louise, La Rocca, Paola, Ladron de Guevara, Pedro, Lakomov, Igor, Langoy, Rune, Lara, Camilo Ernesto, Lardeux, Antoine Xavier, Lazzeroni, Cristina, Le Bornec, Yves, Lea, Ramona, Lechman, Mateusz, Lee, Graham Richard, Lee, Ki Sang, Lee, Sung Chul, Lefevre, Frederic, Lehnert, Joerg Walter, Leistam, Lars, Lemmon, Roy Crawford, Lenhardt, Matthieu Laurent, Lenti, Vito, Leon Monzon, Ildefonso, Leon Vargas, Hermes, Leoncino, Marco, Levai, Peter, Lien, Jorgen, Lietava, Roman, Lindal, Svein, Lindenstruth, Volker, Lippmann, Christian, Lisa, Michael Annan, Liu, Lijiao, Loenne, Per-Ivar, Loggins, Vera, Loginov, Vitaly, Lohn, Stefan Bernhard, Lohner, Daniel, Loizides, Constantinos, Loo, Kai Krister, Lopez, Xavier Bernard, Lopez Torres, Ernesto, Lovhoiden, Gunnar, Lu, Xianguo, Luettig, Philipp, Lunardon, Marcello, Luo, Jiebin, Luparello, Grazia, Luquin, Lionel, Luzzi, Cinzia, Ma, Rongrong, Maevskaya, Alla, Mager, Magnus, Mahapatra, Durga Prasad, Maire, Antonin, Mal'Kevich, Dmitry, Malaev, Mikhail, Maldonado Cervantes, Ivonne Alicia, Malinina, Ludmila, Malzacher, 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Paola, Paic, Guy, Painke, Florian, Pajares, Carlos, Pal, S, Pal, Susanta Kumar, Palaha, Arvinder Singh, Palmeri, Armando, Papikyan, Vardanush, Pappalardo, Giuseppe, Park, Woo Jin, Passfeld, Annika, Patalakha, Dmitri Ivanovich, Paticchio, Vincenzo, Pavlinov, Alexei, Pawlak, Tomasz Jan, Peitzmann, Thomas, Pereira Da Costa, Hugo Denis Antonio, Pereira De Oliveira Filho, Elienos, Peresunko, Dmitri, Perez Lara, Carlos Eugenio, Perez Lezama, Edgar, Perini, Diego, Perrino, Davide, Peryt, Wiktor Stanislaw, Pesci, Alessandro, Peskov, Vladimir, Pestov, Yury, Petracek, Vojtech, Petran, Michal, Petris, Mariana, Petrov, Plamen Rumenov, Petrovici, Mihai, Petta, Catia, Piano, Stefano, Piccotti, Anna, Pikna, Miroslav, Pillot, Philippe, Pinazza, Ombretta, Pinsky, Lawrence, Pitz, Nora, Piuz, Francois, Piyarathna, Danthasinghe, Ploskon, Mateusz Andrzej, Pluta, Jan Marian, Pochybova, Sona, Podesta Lerma, Pedro Luis Manuel, Poghosyan, Martin, Polichtchouk, Boris, Pop, Amalia, Porteboeuf-Houssais, Sarah, 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Oliver, Scioli, Gilda, Scomparin, Enrico, Scott, Patrick Aaron, Scott, Rebecca, Segato, Gianfranco, Selyuzhenkov, Ilya, Senyukov, Serhiy, Seo, Jeewon, Serci, Sergio, Serradilla, Eulogio, Sevcenco, Adrian, Shabetai, Alexandre, Shabratova, Galina, Shahoyan, Ruben, Sharma, Natasha, Sharma, Satish, Shigaki, Kenta, Shimomura, Maya, Shtejer, Katherin, Sibiriak, Yury, Siciliano, Melinda, Sicking, Eva, Siddhanta, Sabyasachi, Siemiarczuk, Teodor, Silvermyr, David Olle Rickard, Silvestre, catherine, Simatovic, Goran, Simonetti, Giuseppe, Singaraju, Rama Narayana, Singh, Ranbir, Singha, Subhash, Singhal, Vikas, Sinha, Bikash, Sinha, Tinku, Sitar, Branislav, Sitta, Mario, Skaali, Bernhard, Skjerdal, Kyrre, Smakal, Radek, Smirnov, Nikolai, Snellings, Raimond, Sogaard, Carsten, Soltz, Ron Ariel, Son, Hyungsuk, Song, Jihye, Song, Myunggeun, Soos, Csaba, Soramel, Francesca, Sputowska, Iwona, Spyropoulou-Stassinaki, Martha, Srivastava, Brijesh Kumar, Stachel, Johanna, Stan, Ionel, Stefanek, Grzegorz, 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Williams, Crispin, Windelband, Bernd Stefan, Xaplanteris Karampatsos, Leonidas, Yaldo, Chris G, Yamaguchi, Yorito, Yang, Hongyan, Yang, Shiming, Yasnopolsky, Stanislav, Yi, JunGyu, Yin, Zhongbao, Yoo, In-Kwon, Yoon, Jongik, Yu, Weilin, Yuan, Xianbao, Yushmanov, Igor, Zach, Cenek, Zampolli, Chiara, Zaporozhets, Sergey, Zarochentsev, Andrey, Zavada, Petr, Zaviyalov, Nikolai, Zbroszczyk, Hanna Paulina, Zelnicek, Pierre, Zgura, Sorin Ion, Zhalov, Mikhail, Zhang, Haitao, Zhang, Xiaoming, Zhou, Daicui, Zhou, Fengchu, Zhou, You, Zhu, Jianhui, Zhu, Xiangrong, Zichichi, Antonino, Zimmermann, Alice, Zinovjev, Gennady, Zoccarato, Yannick Denis, Zynovyev, Mykhaylo, Zyzak, Maksym, UNIVERSIDADE DE ESTADUAL DE CAMPINAS, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Laboratoire de Physique Corpusculaire, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), ALICE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], Nuclear Theory, Matematikk og naturvitenskap: 400::Fysikk: 430::Kjerne- og elementærpartikkelfysikk: 431 [VDP], FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Mathematics and natural scienses: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], High Energy Physics - Experiment, Nuclear Theory (nucl-th), High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Nuclear Physics - Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment, Particle Physics - Experiment
Abstract

The elliptic, $v_2$, triangular, $v_3$, and quadrangular, $v_4$, azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions and (anti-)protons in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range $|��|8$ GeV/$c$. The small $p_{\rm T}$ dependence of the difference between elliptic flow results obtained from the event plane and four-particle cumulant methods suggests a common origin of flow fluctuations up to $p_{\rm T}=8$ GeV/$c$. The magnitude of the (anti-)proton elliptic and triangular flow is larger than that of pions out to at least $p_{\rm T}=8$ GeV/$c$ indicating that the particle type dependence persists out to high $p_{\rm T}$., 16 pages, 5 captioned figures, authors from page 11, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/1860

Published
2012
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17. Study of the structure factor anisotropy and long range correlations of ferrofluids in the dilute low-coupling regime

Author

Alexey O. Ivanov, Ekaterina Krutikova, Vincent Ballenegger, Joan J. Cerdà, Christian Holm, and Ekaterina A. Elfimova

Subjects
Physics, Dipole, Condensed matter physics, Virial expansion, Brillouin and Langevin functions, Hard spheres, Condensed Matter Physics, Radial distribution function, Structure factor, Magnetic dipole–dipole interaction, Electronic, Optical and Magnetic Materials, Magnetic field
Abstract

Dipolar soft-sphere (DSS) fluids in the dilute low-coupling regime are studied via Molecular Dynamic simulations and the extension of a theoretical formalism previously used for dipolar hard spheres in which new terms for the virial expansion of the radial distribution function corresponding to the three-particle contribution are presented and tested for the zero and non-zero magnetic field case. A thorough comparison with simulations shows that the extended formalism is able to account for the structure factors of DSS with and without externally applied magnetic fields in the dilute low-coupling regime: quantitative agreement between theory and simulations is found for dipolar coupling parameters λ≲2λ≲2, and volume fraction φ≲0.25φ≲0.25. When λ>1λ>1 the new added term to the virial expansion is observed to play a crucial role in order to match quantitatively theory and simulations at zero field. In the presence of an external magnetic field our tests show that further improvements are needed and only new terms with Langevin function dependences can significatively contribute to improve the predictions for the dilute low-coupling regime. Numerical simulations show that despite that the ferrofluids considered here are in the dilute low-coupling regime, when an external field is applied, important correlations along the parallel direction to the field and depletion phenomena along the perpendicular direction are observed in the averaged density surrounding a particle., This research has been carried out within the financial support of RFBRGrantno.08-02-00647andDFG -RFBRJointGrantnos.HO1108/ 12-1and06-02-04019,AVCPNo.2.1.1/1535,FASI02.740.11.0202and Grant of President of RF MK-1673.2010.2.

Published
2011

18. Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescentsResearch in context

Author

Yun Huang, Sara Elizabeth Stinson, Malte Thodberg, Louise Aas Holm, Roman Thielemann, Karolina Sulek, Morten Asp Vonsild Lund, Cilius Esmann Fonvig, Min Kim, Kajetan Trost, Helene Bæk Juel, Trine Nielsen, Peter Rossing, Maja Thiele, Aleksander Krag, Cristina Legido-Quigley, Jens-Christian Holm, and Torben Hansen

Subjects
Lipidomics, Genome-wide association study, Children, Cardiometabolic risk, Mendelian randomisation, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: Lipid species are emerging as biomarkers for cardiometabolic risk in both adults and children. The genetic regulation of lipid species and their impact on cardiometabolic risk during early life remain unexplored. Methods: Using mass spectrometry-based lipidomics, we measured 227 plasma lipid species in 1149 children and adolescents (44.8% boys) with a median age of 11.2 years. We performed genome-wide association analyses to identify genetic variants influencing lipid species. Colocalisation and Mendelian randomisation (MR) analyses were performed to infer causality between lipid species and cardiometabolic outcomes. Findings: We identified 37 genome-wide significant loci for 52 lipid species, nine of which are previously unreported. Colocalisation analyses revealed that seven lipid loci shared genetic variants associated with adult cardiometabolic outcomes. One-sample MR analysis identified positive causal associations between ceramides and liver enzymes, sphingomyelins and hemoglobin A1c (HbA1c), and phosphatidylethanolamines and high-sensitivity C-reactive protein in children and adolescents. Two-sample MR using adult-based summary statistics showed consistent direction of associations and indicated additional causal links, specifically between ceramides and elevated HbA1c levels, and phosphatidylinositols with elevated liver enzymes. Interpretation: These findings highlight the potential long-term implications of plasma lipid genetic determinants on cardiometabolic risk. Funding: Novo Nordisk Foundation, The Innovation Fund Denmark, The Danish Heart Foundation, EU Horizon, and LundbeckFonden.

Published
2025
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20. Outcomes following SARS-CoV-2 infection in individuals with and without solid organ transplantation-A Danish nationwide cohort study.

Author

Overvad M, Koch A, Jespersen B, Gustafsson F, Krause TG, Hansen CH, Ethelberg S, and Obel N

Subjects
Humans, SARS-CoV-2, Cohort Studies, RNA, Viral, COVID-19 Vaccines, Denmark epidemiology, COVID-19 epidemiology, Organ Transplantation adverse effects
Abstract

The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, hospitalization and death, and the effects of SARS-CoV-2 vaccines in solid organ transplant recipients (SOTRs) is still debated. We performed a nationwide, population-based, matched cohort study, including all Danish SOTRs (n = 5184) and a matched cohort from the general population (n = 41 472). Cox regression analyses were used to calculate incidence rate ratios (IRRs). SOTRs had a slightly increased risk of SARS-CoV-2 infection and were vaccinated earlier than the general population. The overall risk of hospital contact with COVID-19, severe COVID-19, need for assisted respiration, and hospitalization followed by death was substantially higher in SOTRs (IRR: 32.8 95%CI [29.0-37.0], 9.2 [6.7-12.7], 12.5 [7.6-20.8], 12.4 [7.9-12.7]). The risk of hospitalization and death after SARS-CoV-2 infection decreased substantially in SOTRs after the emergence of the Omicron variant (IRR: 0.45 [0.37-0.56], 0.17 [0.09-0.30]). Three vaccinations reduced the risk of SARS-CoV-2 infection only marginally compared to two vaccinations, but SOTRs with three vaccinations had a lower risk of death (IRR: 022 [0.16-0.35]). We conclude that SOTRs have a risk of SARS-CoV-2 infection comparable to the general population, but substantially increased the risk of hospitalization and death following SARS-CoV-2 infection. A third vaccination only reduces the risk of SARS-CoV2 infection marginally, but SOTRs vaccinated 3 times have reduced mortality., (© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.)

Published
2022
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21. Population-based pediatric reference values for serum parathyroid hormone, vitamin D, calcium, and phosphate in Danish/North-European white children and adolescents.

Author

Vissing Landgrebe A, Asp Vonsild Lund M, Lausten-Thomsen U, Frithioff-Bøjsøe C, Esmann Fonvig C, Lind Plesner J, Aas Holm L, Jespersen T, Hansen T, and Christian Holm J

Subjects
Adolescent, Child, Denmark, Female, Humans, Male, Reference Values, Vitamin D Deficiency, White People, Calcium blood, Parathyroid Hormone blood, Phosphates blood, Vitamin D blood
Abstract

Introduction: Parathyroid hormone (PTH) and vitamin D are essential hormones in bone metabolism, especially during pediatric growth. Vitamin D insufficiency is often asymptomatic and is prevalent in high-latitude countries., Methods: In a Danish population-based cohort of 2211 6-18-year-olds, sex- and age-specific pediatric reference values for fasting concentrations of intact serum PTH, vitamin D (25-hydroxycholecalciferol, 25-OH-D), total calcium, and phosphate were generated in accordance with Clinical and Laboratory Standards Institute (CLSI) EP28-A3c guidelines. The effect of season on these biomarkers of bone metabolism was evaluated., Results: In boys, PTH concentrations increased with age, while the vitamin D and phosphate concentrations decreased (all p < .001). In girls, a peak in PTH concentrations and a nadir in vitamin D concentrations were observed in the 10-14-year-olds (both p < .001). Calcium and phosphate decreased with age for both sexes (girls: both p < .001; boys calcium: p < .05, boys phosphate: p < .001). Vitamin D was 20% lower in winter than summer for both sexes (both p < .001). Individuals with vitamin D sufficiency (25-OH-D > 50 nmol/L) exhibited a 5% lower level of PTH compared to the whole sample population (p < .001)., Conclusion: The concentrations of PTH, vitamin D, calcium, and phosphate vary during childhood and adolescence, and is dependent on sex and season. These factors should be considered when screening for and treating imbalances in bone metabolism., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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22. Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study.

Author

Hansen CH, Michlmayr D, Gubbels SM, Mølbak K, and Ethelberg S

Subjects
Adolescent, Adult, Aged, Child, Child, Preschool, Cohort Studies, Databases, Factual, Denmark epidemiology, Female, Humans, Infant, Male, Middle Aged, COVID-19 Testing, Polymerase Chain Reaction, Reinfection epidemiology, Reinfection immunology, SARS-CoV-2 immunology
Abstract

Background: The degree to which infection with SARS-CoV-2 confers protection towards subsequent reinfection is not well described. In 2020, as part of Denmark's extensive, free-of-charge PCR-testing strategy, approximately 4 million individuals (69% of the population) underwent 10·6 million tests. Using these national PCR-test data from 2020, we estimated protection towards repeat infection with SARS-CoV-2., Methods: In this population-level observational study, we collected individual-level data on patients who had been tested in Denmark in 2020 from the Danish Microbiology Database and analysed infection rates during the second surge of the COVID-19 epidemic, from Sept 1 to Dec 31, 2020, by comparison of infection rates between individuals with positive and negative PCR tests during the first surge (March to May, 2020). For the main analysis, we excluded people who tested positive for the first time between the two surges and those who died before the second surge. We did an alternative cohort analysis, in which we compared infection rates throughout the year between those with and without a previous confirmed infection at least 3 months earlier, irrespective of date. We also investigated whether differences were found by age group, sex, and time since infection in the alternative cohort analysis. We calculated rate ratios (RRs) adjusted for potential confounders and estimated protection against repeat infection as 1 - RR., Findings: During the first surge (ie, before June, 2020), 533 381 people were tested, of whom 11 727 (2·20%) were PCR positive, and 525 339 were eligible for follow-up in the second surge, of whom 11 068 (2·11%) had tested positive during the first surge. Among eligible PCR-positive individuals from the first surge of the epidemic, 72 (0·65% [95% CI 0·51-0·82]) tested positive again during the second surge compared with 16 819 (3·27% [3·22-3·32]) of 514 271 who tested negative during the first surge (adjusted RR 0·195 [95% CI 0·155-0·246]). Protection against repeat infection was 80·5% (95% CI 75·4-84·5). The alternative cohort analysis gave similar estimates (adjusted RR 0·212 [0·179-0·251], estimated protection 78·8% [74·9-82·1]). In the alternative cohort analysis, among those aged 65 years and older, observed protection against repeat infection was 47·1% (95% CI 24·7-62·8). We found no difference in estimated protection against repeat infection by sex (male 78·4% [72·1-83·2] vs female 79·1% [73·9-83·3]) or evidence of waning protection over time (3-6 months of follow-up 79·3% [74·4-83·3] vs ≥7 months of follow-up 77·7% [70·9-82·9])., Interpretation: Our findings could inform decisions on which groups should be vaccinated and advocate for vaccination of previously infected individuals because natural protection, especially among older people, cannot be relied on., Funding: None., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
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24. Prevalence, associations, and adequacy of treatment of major depression in patients with cancer: a cross-sectional analysis of routinely collected clinical data.

Author

Walker J, Hansen CH, Martin P, Symeonides S, Ramessur R, Murray G, and Sharpe M

Abstract

Background: Major depression is an important complication of cancer. However, reliable data are lacking for the prevalence of depression in patients with cancer in different primary sites, the association of depression with demographic and clinical variables within cancer groupings, and the proportion of depressed patients with cancer receiving potentially effective treatment for depression. We investigated these questions with data from a large representative clinical sample., Methods: We analysed data from patients with breast, lung, colorectal, genitourinary, or gynaecological cancer who had participated in routine screening for depression in cancer clinics in Scotland, UK between May 12, 2008, and Aug 24, 2011. Depression screening was done in two stages (first, Hospital Anxiety and Depression Scale; then, major depression section of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition). Data for depression status were linked with demographic and clinical data obtained from the Scottish National Cancer Registry., Findings: We analysed data for 21 151 patients. The prevalence of major depression was highest in patients with lung cancer (13·1%, 95% CI 11·9-14·2%), followed by gynaecological cancer (10·9%, 9·8-12·1), breast cancer (9·3%, 8·7-10·0), colorectal cancer (7·0%, 6·1-8·0), and genitourinary cancer (5·6%, 4·5-6·7). Within these cancer groupings, a diagnosis of major depression was more likely in patients who were younger, had worse social deprivation scores, and, for lung cancer and colorectal cancer, female patients. 1130 (73%) of 1538 patients with depression and complete patient-reported treatment data were not receiving potentially effective treatment., Interpretation: Major depression is common in patients attending cancer clinics and most goes untreated. A pressing need exists to improve the management of major depression for patients attending specialist cancer services., Funding: Cancer Research UK and Chief Scientist Office of the Scottish Government., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Published
2014
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25. Thoughts of death and suicide reported by cancer patients who endorsed the "suicidal thoughts" item of the PHQ-9 during routine screening for depression.

Author

Walker J, Hansen CH, Butcher I, Sharma N, Wall L, Murray G, and Sharpe M

Subjects
Adult, Aged, Aged, 80 and over, Depression psychology, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Young Adult, Attitude to Death, Depression diagnosis, Neoplasms psychology, Psychiatric Status Rating Scales, Suicidal Ideation
Abstract

Background: Patients with serious medical illnesses, such as cancer, are at increased risk of suicide but are also often facing death. The Patient Health Questionnaire-9 (PHQ-9) is widely used to screen patients for depression. It includes an item that asks about thoughts of death and hurting yourself (Item-9)., Objective: To describe the nature of thoughts of death and suicide reported in clinical interviews carried out to further assess suicidal ideation of cancer outpatients who had endorsed the "suicidal thoughts item" (Item-9) of the PHQ-9 during routine depression screening., Method: Secondary analysis of anonymized service data (with ethical approval) derived from the routine clinical administration of self-report questionnaires and telephone interviews to outpatients attending a Cancer Centre in the UK., Results: Complete data were available on 330/463 (71%) of patients who had endorsed Item-9. In a subsequent structured telephone interview, approximately one-third of these patients denied any thoughts that they would be better off dead, another third acknowledged having thoughts that they would be better off dead, but not of suicide, and the remaining third reported clear thoughts of committing suicide., Conclusion: Only one-third of cancer outpatients who endorse the "suicidal thoughts item" of the PHQ-9 report suicidal thoughts at a subsequent interview. Services planning to set up depression screening with the PHQ-9 need to carefully consider the relative benefits and burden to their service and patients of including Item-9 and interviewing all those who endorse it., (Copyright © 2011 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2011
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