1. Preparation of yttrium-90 resin microspheres based on SiO2-Fe3O4 nanomaterials and analysis of their biodistribution
- Author
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Peishang Li, Jian Wu, Yuechen Li, Chentao Luo, Hongzhang Zhang, Haofeng Tang, Ying Wu, and Xiangsheng Kong
- Subjects
Theranostics ,Radiotherapy ,Circulation ,Chelation ,Biocompatibility ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
This study reports the development and evaluation of yttrium-90 (90Y) radiolabeled silica-coated iron oxide (SiO2-Fe3O4) resin microspheres for potential theranostic application in cancer radiation therapy. Iron oxide nanoparticles of average diameter 29.7 nm were synthesized via optimized co-precipitation and displayed superparamagnetic behavior ideal for MRI. Aminosilane surface functionalization enabled covalent conjugation of 1 mmol/g DTPA/DOTA chelators for labeling 2 mCi 90Y per 150 μg nanoparticles with 92 % efficiency when incubated for 45 mins at pH 5.5 and 50°C. In vitro stability assays in buffers and human serum showed excellent 90Y retention (>95 %) up to 48 hours. In vivo biodistribution in Wistar rats revealed extended nanoparticle circulation half-life of 5.2 hours and peak exposure of 22.4 %ID/g compared to rapid clearance of unconjugated 90Y chloride within 1 hour. Complete renal recovery by 72 hours and minimal bone accumulation (
- Published
- 2024
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