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Objective: Osteoradionecrosis (ORN) of the jaw is preceded by dental extractions in up to 10% of cases. We present a case series of post-radiotherapy patients undergoing dental extractions who have received the prophylactic antifibrotic agents pentoxifylline and vitamin E (PVe) to prevent ORN., Study Design: A retrospective review was conducted of 219 patients with head and neck cancer (HNC) undergoing 1079 dental extractions between 2009 and 2020. Data regarding oncological treatment, prophylactic drug regimen, dental history, and clinical outcome was collected., Results: Twelve patients developed ORN at 17 extraction sites (ORN rates, 1.6% and 5.5% at tooth level and patient level, respectively). PVe regimen compliance significantly decreased ORN rates at the patient level (3.4% vs 11.5%; P < .03) and the tooth level (1.0% vs 3.5%; P < .01) compared with no PVe. Regimen compliance significantly reduced ORN rates in patients with oropharyngeal cancer (P < .01); in those with mandibular (P < .005) molar (P < .003), and flapless extractions (P < .04); in patients with radiation regions >40 Gy (P < .0009); and in those who underwent primary closure (P < .03). Machine learning analysis identified almost all these factors as influential at a tooth level for ORN., Conclusions: PVe regimen compliance decreased dental extraction ORN rates more than the literature base rates of 7% at the patient level and 2% at the tooth level. Given its success in managing existing ORN, PVe could be extended prophylactically for dental extractions in irradiated patients with head and neck cancer., (Copyright © 2021 Elsevier Inc. All rights reserved.)

Two-thirds of the world population do not have access to safe, affordable and timely surgery. This global surgical crisis largely affects low and middle-income countries, and it will surpass the challenges created by communicable diseases. The barriers of access to surgery range from cost of surgery and patient transportation to availability and quality of surgical infrastructure and providers. Mercy Ships is a Non-Governmental Organisation (NGO) providing free world-class life-saving and life-transforming surgery to the poorest of the poor in West Africa. In order to address barriers to access surgical assessment and care, Mercy Ships switched from centralised patient selection mainly in port cities or capitals to decentralised selection strategy staffed by experienced nursing teams travelling to remote locations nearer to patients' homes. In this way, the under-served rural population is given equal opportunity to access Mercy Ships' free specialised surgical services. In each country served by the Mercy Ships, a 5 year country engagement program is created to focus on improving the quality of life for people living with disease, disfigurement and disability through free direct medical service to reduce the burden of unmet surgical needs. Moreover, our Medical Capacity Building teams concentrate in improving infrastructure and quality control, equipment donation and maintenance. Lastly, Mercy Ships partner with government and policy makers to improve and strengthen their local surgical care delivery system as an indispensable part of the healthcare system. In this vast sea of global surgical crisis, the vision of the Mercy Ships is to eradicate the 'disease of poverty' and effectively do itself out of a job. Mercy Ships' new and the world's largest (37,000 ton) purpose-built hospital ship, the Global Mercy, is joining our current ship, the Africa Mercy (16,500 ton) to save lives and to strengthen local surgical care service. This will more than double our capacity and impact in sub-Saharan Africa following COVID-19 pandemic. Moreover our state-of-art on-board simulation laboratories and traditional practical training of local healthcare providers will further enhance and build their medical capacity. The Global Mercy will become the largest floating and training platform to train next generation African medical and health care professionals so that they can save countless lives by training others in the future. We therefore invite you to partner with us in bringing hope and healing to the forgotten poor in West Africa., (© 2021 Published by Elsevier B.V. on behalf of Craniofacial Research Foundation.)