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1. Michael addition reaction in C-5 of Camptothecin

Author

Changkuo Zhao, Linming Zuo, Xi Ke, and Xianheng Wang

Subjects
Michael addition, Camptothecin, 5-alkylation, Structure modification, Chemistry, QD1-999
Abstract

A simple method for Michael addition at C-5 of Camptothecin has been developed to construct 5-CPT derivatives. The addition products were obtained with moderate yields, and the structures of the target compounds were characterized by 1H NMR, 13C NMR, and HRMS spectra. The feasibility of various Michael addition acceptors for this reaction has also been investigated.

Published
2024
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