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1. Population-based multicase-control study in common tumors in Spain (MCC-Spain): Rationale and study design = Estudio multicaso-control de base poblacional de tumores comunes en España (MCC-Spain): razón y diseño del estudio

Author

Castaño-Vinyals, Gemma, Aragonés, Nuria, Pérez-Gómez, Beatriz, Martín, Vicente, Llorca, Javier, Moreno, Victor, Altzibar, Jone-Miren, Ardanaz, Eva, Sanjosé Llongueras, Silvia de, Jiménez Moleón, José Juan, García Tardón, Adonina, Alguacil, Juan, Peiró Pérez, Rosana, Marcos-Gragera, Rafael, Navarro, Carmen, Pollán, Marina, Kogevinas, Manolis, Alonso, Maria Teresa, Amiano, Pilar, Arias, Cristina, Azpiri, Mikel, Benavente, Yolanda, Boldo, Elena, Bueno, Aurora, Bustamante, Mariona, Caballero, Francisco Javier, Campo Güerri, Elias, Cantón, Rafael, Capelo, Rocío, Carmona García, Maria Carme, Casabonne, Delphine, Chirlaque, María Dolores, Cirac, Judith, Clofent, Juan, Colado, Enrique, Costas, Laura, Crous, Marta, Campo, Rosa del, Díaz Santos, Marian, Dierssen Sotos, Trinidad, Ederra, María, Espinosa, Ana, Fernández Cabrera, Marieta, Fernández Somoano, Ana, Fernández-Villa, Tania, García García-Esquinas, Esther, García Martín, Paloma, Gómez Acebo, Inés, González Puga, Cristina, Gracia Lavedan, Esther, Guevara, Marcela, Guinó, Elisabet, Huerta, José María, Lope, Virginia, López-Abente Ortega, Gonzalo, López-Otín, Carlos, Martínez Argüelles, Begoña, Merino Salas, Sergio, Mirón Pozo, Benito, Molina de la Torre, Antonio José, Moreno, Eduardo, Moreno Iribas, Conchi, Olea, Nicolás, Osca-Gelis, Gemma, Paré, Laia, Porta, Miquel, Puig, Montse, Rivas del Fresno, Manuel, Robles, Claudia, Rodríguez Suarez, Marta María, Romero, Beatriz, Sáez Castillo, Ana Isabel, Sala i Serra, Maria, Salas Trejo, Dolores, Santaballa, Ana, Santibáñez, Miguel, Sierra, Ángeles, Souto, Ana, Villanueva, Cristina M., Carrasco, Estela, Sabaté, Yasmin, Persavento, Cecília, García, Mireia, Carrasco, Glòria, Expósito, Ainara, Andreu, Montse, Bessa, Xavier, Piracés, Mercè, Lorente, José Antonio, Tusquets, Ignasi, Collet, Inma, Bory, Felip, Pera, Manuel, Abella, Eugènia, Garcia, Francesc, Salar, Antonio, Piñol, Marta, Fernández-Llamazares Rodríguez, Jaume, Viciano Martín, Marta, and Garsot, Elisenda

Subjects
Epidemiology, Epidemiologia, Càncer, Cancer
Abstract

MCC-Spain study group: Maria Teresa Alonso, Pilar Amiano, Cristina Arias, Mikel Azpiri, Yolanda Benavente, Elena Boldo, Aurora Bueno, Mariona Bustamante, Francisco Javier Caballero, Elías Campo, Rafael Cantón, Rocío Capelo, Carme Carmona, Delphine Casabonne, María Dolores Chirlaque, Judith Cirac, Juan Clofent, Enrique Colado, Laura Costas, Marta Crous, Rosa del Campo, Marian Díaz Santos, Trinidad Dierssen-Sotos, María Ederra, Ana Espinosa, Marieta Fernández Cabrera, Ana Fernández Somoano, Fernández-Villa, Tania, Esther García García-Esquinas, Paloma García Martín, Inés Gómez-Acebo, Cristina González Puga, Esther Gràcia, Marcela Guevara Eslava, Elisabet Guinó, José María Huerta, Virginia Lope, Gonzalo López-Abente, Carlos Lopez-Otín, Begona˜ Martinez Argüelles, Sergio Merino Salas, Benito Mirón Pozo, Antonio José Molina de la Torre, Eduardo Moreno, Concepción Moreno Iribas, Nicolás Olea, Gemma Osca Gelis, Laia Paré, Miquel Porta, Montse Puig, Manuel Rivas del Fresno, Claudia Robles, Marta María Rodríguez Suarez, Beatriz Romero, Ana Isabel Sáez Castillo, Maria Sala Serra, Dolores Salas Trejo, Ana Santaballa, Miguel Santibánez, ˜ Ángeles Sierra, Ana Souto, Cristina M Villanueva We present the protocol of a large population-based case-control study of 5 common tumorsin Spain (MCC-Spain) that evaluates environmental exposures and genetic factors.Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and pri-mary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer,1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chroniclymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age,sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) andfrom 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociode-mographic factors, environmental exposures, occupation, medication, lifestyle, and personal and familymedical history. In addition, participants completed a self-administered food-frequency questionnaireand telephone interviews. Blood samples were collected from 76% of participants while saliva sampleswere collected in CLL cases and participants refusing blood extractions. Clinical information was recordedfor cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals.Genotyping was done through an exome array enriched with genetic markers in specific pathways. Mul-tiple analyses are planned to assess the association of environmental, personal and genetic risk factorsfor each tumor and to identify pleiotropic effects.Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiol-ogy & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancersand will promote cancer research and prevention in Spain

Published
2020

2. Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study

Author

Medicina Preventiva, Peremiquel Trillas, Paula, Benavente, Yolanda, Martín Bustamante, Mayte, Casabonne, Delphine, Pérez Gómez, Beatriz, Gómez Acebo, Inés, Oliete Canela, Anna, Diéguez Rodríguez, Marta, Tusquets, Ignasi, Amiano, Pilar, Mengual, Lourdes, Ardanaz, Eva, Capelo, Rocío, Molina de la Torre, Antonio José, Salas Trejo, Dolores, Fernández Tardón, Guillermo, Lope, Virginia, Jiménez Moleón, José J., Marcos Gragera, Rafael, Dierssen Sotos, Trinidad, Azpiri, Mikel, Muñoz, Montse, Guevara, Marcela, Fernández Villa, Tania, Molina Barceló, Ana, Aragonés, Nuria, Pollán, Marina, Castaño Vinyals, Gemma, Alguacil, Juan, Kogevinas, Manolis, Sanjosé, Silvia de, Costas, Laura, Medicina Preventiva, Peremiquel Trillas, Paula, Benavente, Yolanda, Martín Bustamante, Mayte, Casabonne, Delphine, Pérez Gómez, Beatriz, Gómez Acebo, Inés, Oliete Canela, Anna, Diéguez Rodríguez, Marta, Tusquets, Ignasi, Amiano, Pilar, Mengual, Lourdes, Ardanaz, Eva, Capelo, Rocío, Molina de la Torre, Antonio José, Salas Trejo, Dolores, Fernández Tardón, Guillermo, Lope, Virginia, Jiménez Moleón, José J., Marcos Gragera, Rafael, Dierssen Sotos, Trinidad, Azpiri, Mikel, Muñoz, Montse, Guevara, Marcela, Fernández Villa, Tania, Molina Barceló, Ana, Aragonés, Nuria, Pollán, Marina, Castaño Vinyals, Gemma, Alguacil, Juan, Kogevinas, Manolis, Sanjosé, Silvia de, and Costas, Laura

Abstract

[EN] Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case–control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01–1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02–1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00–1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies

3. Epstein Barr virus antibody reactivity and gastric cancer: A population-based case-control study.

Author

Aragonés N, Fernández de Larrea N, Pastor-Barriuso R, Michel A, Romero B, Pawlita M, Mayorgas-Torralba S, Martín V, Moreno V, Casabonne D, Castilla J, Fernandez-Tardón G, Dierssen-Sotos T, Capelo R, Salas D, Salcedo-Bellido I, Chirlaque MD, Brenner N, Pedraza M, Bessa X, Pérez-Gómez B, Butt J, Kogevinas M, Del Campo R, de Sanjosé S, Waterboer T, and Pollán M

Subjects
Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors, Stomach Neoplasms pathology, Epstein-Barr Virus Infections complications, Stomach Neoplasms virology
Abstract

Background: In contrast to the recognized role of Helicobacter pylori in the etiology of non-cardia gastric cancer (GC), there is still insufficient epidemiological evidence for the involvement of Epstein-Barr virus (EBV) in gastric carcinogenesis. We aimed to evaluate the relation of antibody profile and antibody reactivity intensity against four individual EBV proteins to GC risk., Methods: We used information from 281 GC cases and 2071 age and sex frequency matched controls recruited in the frame of the MCC-Spain multicase-control study, between 2008 and 2013. Sociodemographic, lifestyle and environmental factors were assessed in face-to-face interviews. Antibody responses to four EBV proteins (EBNA-1, ZEBRA, EA-D, and VCA-p18) were analyzed by multiplex serology. Odds ratios (OR) and 95% confidence intervals were calculated by using logistic regression mixed models to evaluate the association of seropositivity and antibody reactivity against EBV proteins with GC, adjusting for GC risk factors. Stratified analyses by tumor location (cardia vs. non-cardia) and morphology (intestinal vs. diffuse) were done., Results: Among controls, seropositivity for EA-D, ZEBRA, EBNA-1 and VCA-p18 was 85%, 91%, 97% and 99%, respectively. Even though seropositivity for none of the studied proteins was associated with a higher GC risk, increasing antibody reactivity against EBNA-1 and VCA-p18 was associated with higher OR of GC. This association was present for cardia and non-cardia cancer cases, and for intestinal and diffuse types., Conclusion: Our results support the hypothesis that EBV may play a role in GC etiology, and highlight the importance of evaluating specific antibodies and the dose-response relations when studying widespread infections., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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4. Concentrations and correlations of disinfection by-products in municipal drinking water from an exposure assessment perspective.

Author

Villanueva CM, Castaño-Vinyals G, Moreno V, Carrasco-Turigas G, Aragonés N, Boldo E, Ardanaz E, Toledo E, Altzibar JM, Zaldua I, Azpiroz L, Goñi F, Tardón A, Molina AJ, Martín V, López-Rojo C, Jiménez-Moleón JJ, Capelo R, Gómez-Acebo I, Peiró R, Ripoll M, Gracia-Lavedan E, Nieuwenhujsen MJ, Rantakokko P, Goslan EH, Pollán M, and Kogevinas M

Subjects
Acetonitriles analysis, Chloral Hydrate analysis, Furans analysis, Hydrocarbons, Chlorinated analysis, Principal Component Analysis, Spain, Trihalomethanes analysis, Water Purification, Water Supply analysis, Disinfection methods, Drinking Water analysis, Drinking Water chemistry, Water Pollutants, Chemical analysis
Abstract

Although disinfection by-products (DBPs) occur in complex mixtures, studies evaluating health risks have been focused in few chemicals. In the framework of an epidemiological study on cancer in 11 Spanish provinces, we describe the concentration of four trihalomethanes (THMs), nine haloacetic acids (HAA), 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), four haloacetonitries, two haloketones, chloropicrin and chloral hydrate and estimate correlations. A total of 233 tap water samples were collected in 2010. Principal component analyses were conducted to reduce dimensionality of DBPs. Overall median (range) level of THMs and HAAs was 26.4 (0.8-98.1) and 26.4 (0.9-86.9) μg/l, respectively (N=217). MX analysed in a subset (N=36) showed a median (range) concentration of 16.7 (0.8-54.1)ng/l. Haloacetonitries, haloketones, chloropicrin and chloral hydrate were analysed in a subset (N=16), showing levels from unquantifiable (<1 μg/l) to 5.5 μg/l (dibromoacetonitrile). Spearman rank correlation coefficients between DBPs varied between species and across areas, being highest between dibromochloromethane and dibromochloroacetic acid (r(s)=0.87). Principal component analyses of 13 DBPs (4 THMs, 9 HAAs) led 3 components explaining more than 80% of variance. In conclusion, THMs and HAAs have limited value as predictors of other DBPs on a generalised basis. Principal component analysis provides a complementary tool to address the complex nature of the mixture., (Copyright © 2012 Elsevier Inc. All rights reserved.)

Published
2012
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