Author: "CEREZO" / Publisher: elsevier - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"CEREZO"' showing total 382 results

Start Over Author "CEREZO" Publisher elsevier

382 results on '"CEREZO"'

1. Tools for a personalized tacrolimus dose adjustment in the follow-up of renal transplant recipients. Metabolizing phenotype according to CYP3A genetic polymorphisms versus concentration-dose ratio

Author: Anna Vidal-Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Alex Favà, Josep M. Cruzado, Joan Torras, Josep M. Grinyó, and Nuria Lloberas
Subjects: Tacrolimus, Trasplante renal, Inmunosupresión, Monitorización terapéutica, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Background and justification: The strategy of the concentration-dose (C/D) approach and the different profiles of tacrolimus (Tac) according to the cytochrome P450 polymorphisms (CYPs) focus on the metabolism of Tac and are proposed as tools for the follow-up of transplant patients. The objective of this study is to analyse both strategies to confirm whether the stratification of patients according to the pharmacokinetic behaviour of C/D corresponds to the classification according to their CYP3A4/5 cluster metabolizer profile. Materials and methods: 425 kidney transplant patients who received Tac as immunosuppressive treatment have been included. The concentration/dose ratio (C/D) was used to divide patients in terciles and classify them according to their Tac metabolism rate (fast, intermediate, and slow). Based on CYP3A4 and A5 polymorphisms, patients were classified into 3 metabolizer groups: fast (CYP3A5*1 carriers and CYP34A*1/*1), intermediate (CYP3A5*3/3 and CYP3A4*1/*1) and slow (CYP3A5*3/*3 and CYP3A4*22 carriers). Results: When comparing patients included in each metabolizer group according to C/D ratio, 47% (65/139) of the fast metabolizers, 85% (125/146) of the intermediate and only 12% (17/140) of the slow also fitted in the homonym genotype group. Statistically lower Tac concentrations were observed in the fast metabolizers group and higher Tac concentrations in the slow metabolizers when compared with the intermediate group both in C/D ratio and polymorphisms criteria. High metabolizers required approximately 60% more Tac doses than intermediates throughout follow-up, while poor metabolizers required approximately 20% fewer doses than intermediates. Fast metabolizers classified by both criteria presented a higher percentage of times with sub-therapeutic blood Tac concentration values. Conclusion: Determination of the metabolizer phenotype according to CYP polymorphisms or the C/D ratio allows patients to be distinguished according to their exposure to Tac. Probably the combination of both classification criteria would be a good tool for managing Tac dosage for transplant patients. Resumen: Antecedentes y justificación: La estrategia de la aproximación concentración-dosis (C/D) y los distintos perfiles del tacrolimus (Tac) según los polimorfismos del citocromo P450 (CYPs) se centran en el metabolismo de Tac y se plantean como herramientas para el seguimiento de los pacientes trasplantados. El objetivo de este estudio es comparar la exposición al Tac analizado según ambas estrategias. Materiales y métodos: Se han incluido 425 pacientes trasplantados renales. El cálculo del cociente concentración Tac/dosis (C/D) permitió dividir la población en terciles y clasificar los pacientes según su tasa de metabolismo del Tac en 3 grupos (rápida, intermedia y lenta). En base los polimorfismos del CYP3A4 y A5, los pacientes se agruparon en metabolizadores rápidos (portadores del CYP3A5*1 y CYP34A *1/*1), intermedios (CYP3A5*3/3 y CYP3A4*1/*1) y lentos (CYP3A5 *3/*3 y portadores del CYP3A4*22). Resultados: Al comparar los pacientes de cada grupo metabolizador según los dos criterios coincidieron el 47% (65/139) de los metabolizadores rápidos, el 85% (125/146) de los intermedios y solo el 12% (17/140) de los lentos. Se observaron concentraciones de Tac estadísticamente menores en los metabolizadores rápidos y concentraciones mayores en los lentos, comparándolos con el grupo intermedio según el cociente C/D o según polimorfismos. Los metabolizadores rápidos requirieron alrededor del 60% más de dosis de Tac que los intermedios a lo largo del seguimiento, mientras que los lentos aproximadamente un 20% menos de dosis que los intermedios. Los metabolizadores rápidos clasificados por ambos criterios presentan un porcentaje mayor de veces con valores de concentración de Tac en sangre infra-terapéuticos. Conclusión: La determinación del fenotipo metabolizador según los polimorfismos del CYP o bien cociente C/D permite distinguir los pacientes según su exposición al Tac. Probablemente la combinación de ambos criterios de clasificación sería una buena herramienta en el manejo de la dosificación de Tac para los pacientes trasplantados.
Published: 2024
Full Text: View/download PDF

2. Herramientas para un ajuste de dosis de tacrolimus más personalizado en el seguimiento de los pacientes con transplante renal. Fenotipo metabolizador según polimorfismos genéticos del CYP3A vs. el cociente concentración-dosis

Author: Anna Vidal-Alabró, Helena Colom, Pere Fontova, Gema Cerezo, Edoardo Melilli, Núria Montero, Ana Coloma, Anna Manonellas, Alexandre Favà, Josep M. Cruzado, Joan Torras, Josep M. Grinyó, and Núria Lloberas
Subjects: Tacrolimus, Kidney transplantation, Immunosuppression, Therapeutic drug monitoring, Pharmacokinetics, Pharmacogenetics, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Resumen: Antecedentes y justificación: La estrategia de la aproximación concentración-dosis (C/D) y los distintos perfiles del tacrolimus (Tac), según los polimorfismos del citocromo P450 (CYPs) se centran en el metabolismo de Tac y se plantean como herramientas para el seguimiento de los pacientes trasplantados. El objetivo de este estudio es comparar la exposición al Tac analizado según ambas estrategias. Materiales y métodos: Se han incluido 425 pacientes trasplantados renales. El cálculo del cociente concentración Tac/dosis (C/D) permitió dividir la población en terciles y clasificar los pacientes según su tasa de metabolismo del Tac en tres grupos (rápida, intermedia y lenta). Con base en los polimorfismos del CYP3A4 y A5, los pacientes se agruparon en metabolizadores rápidos (portadores del CYP3A5*1 y CYP34A *1/*1), intermedios (CYP3A5*3/3 y CYP3A4*1/*1) y lentos (CYP3A5 *3/*3 y portadores del CYP3A4*22). Resultados: Al comparar los pacientes de cada grupo metabolizador según los dos criterios, coincidieron 47% (65/139) de los metabolizadores rápidos, 85% (125/146) de los intermedios y solo 12% (17/140) de los lentos. Se observaron concentraciones de Tac estadísticamente menores en los metabolizadores rápidos y concentraciones mayores en los lentos, comparándolos con el grupo intermedio según el cociente C/D o según polimorfismos. Los metabolizadores rápidos requirieron alrededor de 60% más de dosis de Tac que los intermedios a lo largo del seguimiento, mientras que los lentos aproximadamente 20% menos de dosis que los intermedios. Los metabolizadores rápidos clasificados por ambos criterios presentan un porcentaje mayor de veces con valores de concentración de Tac en sangre infraterapéuticos. Conclusión: La determinación del fenotipo metabolizador según los polimorfismos del CYP o bien cociente C/D permite distinguir los pacientes según su exposición al Tac. Probablemente la combinación de ambos criterios de clasificación sería una buena herramienta en el manejo de la dosificación de Tac para los pacientes trasplantados. Abstract: Background and justification: The strategy of the concentration–dose (C/D) approach and the different profiles of tacrolimus (Tac) according to the cytochrome P450 polymorphisms (CYPs) focus on the metabolism of Tac and are proposed as tools for the follow-up of transplant patients. The objective of this study is to analyse both strategies to confirm whether the stratification of patients according to the pharmacokinetic behaviour of C/D corresponds to the classification according to their CYP3A4/5 cluster metabolizer profile. Materials and methods: Four hundred and twenty-five kidney transplant patients who received Tac as immunosuppressive treatment have been included. The concentration/dose ratio (C/D) was used to divided patients in terciles and classify them according to their Tac metabolism rate (fast, intermediate, and slow). Based on CYP3A4 and A5 polymorphisms, patients were classified into three metabolizer groups: fast (CYP3A5*1 and CYP34A*1/*1 carriers), intermediate (CYP3A5*3/3 and CYP3A4*1/*1) and slow (CYP3A5*3/*3 and CYP3A4*22 carriers). Results: When comparing patients included in each metabolizer group according to C/D ratio, 47% (65/139) of the fast metabolizers, 85% (125/146) of the intermediate and only 12% (17/140) of the slow also fitted in the homonym genotype group. Statistically lower Tac concentrations were observed in the fast metabolizers group and higher Tac concentrations in the slow metabolizers when compared with the intermediate group both in C/D ratio and polymorphisms criteria. High metabolizers required approximately 60% more Tac doses than intermediates throughout follow-up, while poor metabolizers required approximately 20% fewer doses than intermediates. Fast metabolizers classified by both criteria presented a higher percentage of times with sub-therapeutic blood Tac concentration values. Conclusion: Determination of the metabolizer phenotype according to CYP polymorphisms or the C/D ratio allows patients to be distinguished according to their exposure to Tac. Probably the combination of both classification criteria would be a good tool for managing Tac dosage for transplant patients.
Published: 2024
Full Text: View/download PDF

3. Innovative device for crack monitoring and deflection analysis in structures: Improved accuracy, safety and efficiency

Author: Alfonso C. Marcos-Romero, Laura Mendoza-Cerezo, Antonio Macías-García, Noelia Rebollo Muñoz, and Jesús M. Rodríguez-Rego
Subjects: Cracks, Cracking, Load testing, Device, Structural health monitoring (SHM), Building information modeling (BIM), Technology
Abstract: It is of the utmost importance to ensure the structural integrity of buildings in order to guarantee the safety of their occupants. Conventional techniques for monitoring cracks and conducting flexural analysis during loading and unloading tests frequently prove inadequate in terms of accuracy and safety. This study introduces ES1293890 U, an innovative dual-purpose device designed for the precise remote monitoring of cracks and comprehensive flexural analysis. The device is integrated seamlessly into structural health monitoring (SHM) and building information modelling (BIM) systems, thereby providing a holistic approach to structural assessment.The ES1293890 U device offers superior accuracy, with a resolution of 0.01 mm and a maximum deviation of 0.007 mm, which makes it a more effective alternative to existing commercial solutions. The utilisation of recycled and biodegradable materials has the effect of reducing production costs, thereby facilitating the undertaking of more frequent and economically viable testing and monitoring. This enhanced affordability is of paramount importance for the maintenance of building safety and structural integrity through regular assessments.A noteworthy attribute of the ES1293890 U is its capacity to conduct remote measurements, obviating the necessity for professionals to enter potentially hazardous test areas. This not only ensures the safety of personnel but also enables continuous and uninterrupted monitoring, with real-time data capture facilitating timely and informed decision-making.In comparison to traditional gauges, the ES1293890 U exhibits enhanced performance in the monitoring of slab deflections, attributable to its elevated accuracy and comprehensive data acquisition capabilities. This device represents a substantial advancement in structural assessment technology, providing a reliable and efficient tool for improving building safety and integrity. The ES1293890 U's innovative approach and cost-effective design have the potential to revolutionise structural monitoring practices, making it an invaluable asset to both the scientific community and the construction industry.
Published: 2024
Full Text: View/download PDF

4. Energy, economic, and environmental analysis of energy efficiency and building policies in Southern Europe. Envelope renovation and renewable energy source integration

Author: Cerezo-Narváez, Alberto, primary, Delgado Guerrero, MCarmen, additional, Sánchez Ramos, José, additional, and Álvarez Domínguez, Servando, additional
Published: 2024
Full Text: View/download PDF

5. New concept of a hybrid renewable solution for urban environment: electricity during daytime and cooling water during nighttime

Author: Guerrero Delgado, MCarmen, primary, Sánchez Ramos, José, additional, Cerezo-Narváez, Alberto, additional, and Álvarez Domínguez, Servando, additional
Published: 2024
Full Text: View/download PDF

6. List of contributors

Author: Agarwal, Rachit, primary, Álvarez Domínguez, Servando, additional, Arumugam, A., additional, Barandica, Naia, additional, Bertolini, Marina, additional, Beryozkina, Svetlana, additional, Cañadas, Inmaculada, additional, Castellini, Marta, additional, Cerezo-Narváez, Alberto, additional, Chen, Jingwei, additional, Delgado Guerrero, MCarmen, additional, Dietrich, Kristin, additional, Efraín, Gómez-Arias, additional, Farchado, Meryem, additional, Fernández-García, Aránzazu, additional, Ghulomzoda, Anvari, additional, González-Ávila, Itzayana, additional, Gubin, Pavel, additional, Guerrero Delgado, MCarmen, additional, Guo, Yilin, additional, Hooshyari, Liya, additional, Hua, Shiyang, additional, Jato-Espino, Daniel, additional, Lakshaya, M., additional, Lei, Yuwei, additional, Liang, Jinping, additional, Matrenin, Pavel, additional, Morales, Ángel, additional, Moretto, Michele, additional, Naik B., Srinivasarao, additional, Óscar, López-Villagómez, additional, Pathak, Shray, additional, Prabakaran, S., additional, Quaranta, Emanuele, additional, Rahul, S., additional, Rawat, Pradeep, additional, Safaraliev, Murodbek, additional, Saliou, Guillaume, additional, San Vicente, Gema, additional, Sánchez Ramos, José, additional, Sánchez-Moreno, Ricardo, additional, Sharma, Geetika, additional, Sudalai, S., additional, Sutter, Florian, additional, Tian, Zhuang, additional, Valliammai, N., additional, Varshiny, S., additional, Vergalli, Sergio, additional, Wang, Jinhui, additional, Wei, Zheng, additional, Wette, Johannes, additional, Wu, Xiaomin, additional, Yang, Yixin, additional, Zaboli, Sohrab, additional, Zarei, Ahmad, additional, Zhou, Daming, additional, and Zicmane, Inga, additional
Published: 2024
Full Text: View/download PDF

7. A response to 'Should children under 5 and those with constipation be overlooked from ARFID research?'

Author: Javier Sanchez-Cerezo, Josephine Neale, Nikita Julius, Tim Croudace, Richard M. Lynn, Lee D. Hudson, and Dasha Nicholls
Subjects: Medicine (General), R5-920
Published: 2024
Full Text: View/download PDF

8. Enhancing active aging through IRAGE: Mitigating social isolation with intergenerational gaming

Author: Manel Díaz, Rosa M. Gil, Luisa F. Cabeza, Eva Cerezo, and Mercè Teixidó
Subjects: Human-computer interaction (HCI), Intergenerational communication, Remote access, Social isolation, Well-being, Active aging, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: This paper presents the outcomes of a pioneering study that explores the potential of remote intergenerational communication to combat social isolation among children and older adults, especially under constraints posed by pandemics such as COVID-19. Acknowledging the limited mobility of many older adults, this research aims to provide insights into how digital platforms can facilitate meaningful exchanges between generations. Utilizing a mixed methodology approach, the study first conducted a user interaction analysis to outline guidelines for participant engagement with the Information and Communication Technology (ICT)-based tool called IRAGE (Intergenerational Remote Access to Gaming Experiences) designed specifically for this purpose. Following the development of the ICT tool, three sessions of the remote intergenerational experience were held, during which participants' interactions were recorded and subsequently analyzed quantitatively and qualitatively. Key findings from the study reveal that remote intergenerational communication can significantly mitigate feelings of isolation among older adults, contributing to their mental health and emotional well-being. Moreover, the study highlights the effectiveness of the web-based platform in facilitating these interactions, with older adults and children finding the user interface intuitive and the overall experience engaging. These outcomes underscore the importance of leveraging technology to maintain social connections during challenging times and offer valuable guidelines for developing ICT tools that cater to the needs of diverse user groups. By demonstrating the feasibility and benefits of remote intergenerational communication, this research contributes to the broader discourse on active aging and the role of digital technologies in promoting social inclusion and emotional health.
Published: 2024
Full Text: View/download PDF

9. Consensus document on the management of hyperkalemia

Author: Alberto Ortiz, Carmen del Arco Galán, José Carlos Fernández-García, Jorge Gómez Cerezo, Rosa Ibán Ochoa, Julio Núñez, Francisco Pita Gutiérrez, and Juan F. Navarro-González
Subjects: Hiperpotasemia, Ciclosilicato de sodio y zirconio, Patiromer, Tratamiento, Enfermedad renal crónica, Insuficiencia cardiaca, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Hyperkalaemia is a common electrolyte imbalance with potentially serious short-, medium- and long-term consequences on morbidity and mortality rates and the use of national health service resources. The fact that different medical specialities can manage hyperkalaemia makes it important to have a unified approach, and the recent availability of new specific drug treatments means that the approach needs to be updated. This consensus document from the scientific societies most directly involved in the management of hyperkalaemia (Sociedad Española de Cardiología [Spanish Society of Cardiology], Sociedad Española de Endocrinología y Nutrición [Spanish Society of Endocrinology and Nutrition], Sociedad Española de Medicina Interna [Spanish Society of Internal Medicine], Sociedad Española de Medicina de Urgencias y Emergencias [Spanish Society of Accident and Emergency Medicine] and Sociedad Española de Nefrología [Spanish Society of Nephrology]) first of all reviews basic aspects of potassium balance and blood potassium. Then it goes on to focus on the concept, epidemiology, pathophysiology and diagnostic and therapeutic approaches to hyperkalaemia. The available evidence and the main published studies have been reviewed with the aim of providing a useful tool in the multidisciplinary approach to patients with hyperkalaemia. Resumen: La hiperpotasemia es una alteración electrolítica frecuente con consecuencias potencialmente graves a corto, medio y largo plazo, tanto en términos de morbilidad y mortalidad como de consumo de recursos del Sistema Nacional de Salud. El abordaje de la hiperpotasemia por diversas especialidades médicas y la reciente disponibilidad de nuevos tratamientos farmacológicos específicos hace necesaria una acción unificada y actualizada. El presente documento de consenso entre las sociedades científicas más directamente implicadas en el abordaje de la hiperpotasemia (Sociedad Española de Cardiología, Sociedad Española de Endocrinología y Nutrición, Sociedad Española de Medicina Interna, Sociedad Española de Medicina de Urgencias y Emergencias y Sociedad Española de Nefrología) repasa, en primer lugar, aspectos básicos del balance de potasio y de la potasemia, centrándose posteriormente en el concepto, epidemiología, fisiopatología, y abordaje diagnóstico y terapéutico de la hiperpotasemia. Se han revisado las evidencias y los principales estudios publicados con el objetivo de que sea una herramienta útil en el abordaje multidisciplinar del paciente con hiperpotasemia.
Published: 2023
Full Text: View/download PDF

10. Fuzzy logic controller for UAV with gains optimized via genetic algorithm

Author: Omar Rodríguez-Abreo, Juvenal Rodríguez-Reséndiz, A. García-Cerezo, and José R. García-Martínez
Subjects: Fuzzy logic, UAV, Metaheuristic algorithm, Genetic algorithm, Optimization, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: A gains optimizer of a fuzzy controller system for an Unmanned Aerial Vehicle (UAV) based on a metaheuristic algorithm is developed in the present investigation. The contribution of the work is the adjustment by the Genetic Algorithm (GA) to tune the gains at the input of a fuzzy controller. First, a typical fuzzy controller was modeled, designed, and implemented in a mathematical model obtained by Newton-Euler methodology. Subsequently, the control gains were optimized using a metaheuristic algorithm. The control objective is that the UAV consumes the least amount of energy. With this basis, the Genetic Algorithm finds the necessary gains to meet the design parameters. The tests were performed using the Matlab-Simulink environment. The results indicate an improvement, reducing the error in tracking trajectories from 30% in some tasks and following trajectories that could not be completed without a tuned controller in other tasks.
Published: 2024
Full Text: View/download PDF

11. Subtypes of avoidant/restrictive food intake disorder in children and adolescents: a latent class analysisResearch in context

Author: Javier Sanchez-Cerezo, Josephine Neale, Nikita Julius, Tim Croudace, Richard M. Lynn, Lee D. Hudson, and Dasha Nicholls
Subjects: ARFID, Eating and feeding disorders, Children and adolescents, Latent class analysis, ASD, Medicine (General), R5-920
Abstract: Summary: Background: The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) describes three primary avoidant/restrictive food intake disorder (ARFID) subtypes including sensory sensitivity, lack of interest in food or eating, and fear of aversive consequences. Studies exploring these subtypes have yielded varying results. We used latent class analysis (LCA) based on the psychopathology of ARFID in a sample of children and adolescents to empirically identify classes. Methods: We carried out a surveillance study of ARFID in collaboration with the British Paediatric Surveillance Unit (BPSU) and the Child and Adolescent Psychiatry Surveillance System (CAPSS) in the United Kingdom and the Republic of Ireland from 1st of March 2021 to 31st of March 2022. Paediatricians and child and adolescent psychiatrists were contacted monthly to report newly diagnosed cases of ARFID electronically and complete a detailed clinical questionnaire. Cases aged 5–18 years were included. LCA was performed specifying 1–6 classes and likelihood-based tests for model selection. The Bayesian Information Criterion (BIC), the Akaike Information Criterion (AIC) and the Sample-Size Adjusted BIC were used to determine the most parsimonious model. Analysis of variance (ANOVA) and χ2 tests were used to compare the characteristics of the identified classes. A multinomial logistic regression (MLR) was performed to investigate predicting factors for the latent classes. Findings: We identified 319 children and adolescents with ARFID. LCA revealed four distinct classes which were labelled as Fear subtype, Lack of Interest subtype, Sensory subtype, and Combined subtype. The probability of being classified as these were 7.2% (n = 23), 25.1% (n = 80), 29.5% (n = 94) and 38.2% (n = 122), respectively. Age at diagnosis, sex, weight loss, distress associated with eating, and autism spectrum disorder diagnosis were identified as predictors of class membership. Interpretation: LCA identified four different classes in a sample of children and adolescents with ARFID. The Combined Subtype, a mixed presentation was the most common. The other three classes resembled the subtypes described in the literature. Clinicians should be aware of these different presentations of ARFID as they may benefit from different clinical interventions. Funding: This study was funded by the Former EMS Ltd (charity number 1098725, registered October 9th 2017).
Published: 2024
Full Text: View/download PDF

12. Dalbavancina como terapia inicial y de consolidación en infecciones endovasculares en un hospital de segundo nivel de la comunidad de madrid

Author: I. Cabello Rojano, J.M. Maza Ortiz, L. Moll Taltavull, P. Ruiz Seco, P. González Ruano, I. Suarez García, and J.F. Gómez Cerezo
Subjects: Medicine, Surgery, RD1-811
Published: 2024
Full Text: View/download PDF

13. GUT MICROBIOME SPECIFIC CHANGES IN DIFFERENT BEHAVIORAL PROFILES IN A MOUSE SOCIAL DEFEAT STRESS MODEL

Author: María Inmaculada Infantes López, Marta Domínguez, Isabel Cerezo, Emma Zambrana Infantes, Miguel Moriñigo, Carmen Pedraza, and Margarita Pérez Martín
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published: 2023
Full Text: View/download PDF

14. Uncertainty modeling in electrical power engineering: stochastic programming

Author: García-Bertrand, Raquel, primary, Baringo, Luis, additional, and García-Cerezo, Álvaro, additional
Published: 2023
Full Text: View/download PDF

15. Ferrite nanoparticles for hyperthermia

Author: Santana-Otero, Antonio, primary, Gómez-Cerezo, D., additional, Lozano-Pedraza, C., additional, López-Méndez, R., additional, Sanz-de Diego, E., additional, Ortega-Juliá, J., additional, Espinosa, A., additional, Teran, F.J., additional, and Ortega, Daniel, additional
Published: 2023
Full Text: View/download PDF

16. Uncertainty modeling in electrical power engineering: robust optimization

Author: García-Bertrand, Raquel, primary, Baringo, Luis, additional, and García-Cerezo, Álvaro, additional
Published: 2023
Full Text: View/download PDF

17. Introduction to probability theory

Author: García-Bertrand, Raquel, primary, Baringo, Luis, additional, and García-Cerezo, Álvaro, additional
Published: 2023
Full Text: View/download PDF

18. Unveiling the interaction modes of Imiquimod with DNA: Biophysical and computational studies

Author: Science and Engineering Research Board (India), University Grants Commission (India), Universidad Autónoma de Madrid, #NODATA#, Sharma, Sudhanshu [0009-0001-7474-8914], Cerezo, Javier [0000-0003-4820-4371], Gavvala, Krishna [0000-0001-7438-2716], Takkella, Dineshbabu, Sharma, Sudhanshu, Vishwakarma, Jyoti, Cerezo, Javier, Martínez-Fernández, Lara, Gavvala, Krishna, Science and Engineering Research Board (India), University Grants Commission (India), Universidad Autónoma de Madrid, #NODATA#, Sharma, Sudhanshu [0009-0001-7474-8914], Cerezo, Javier [0000-0003-4820-4371], Gavvala, Krishna [0000-0001-7438-2716], Takkella, Dineshbabu, Sharma, Sudhanshu, Vishwakarma, Jyoti, Cerezo, Javier, Martínez-Fernández, Lara, and Gavvala, Krishna
Abstract: Herein the manuscript, we report the interaction of an important drug, Imiquimod (IMQ), with Calf Thymus Deoxyribonucleic Acid (ct-DNA). Despite of being used IMQ in multiple medicinal applications such as immune response modifier, antitumor and antiviral drug its interaction with DNA is not studied yet. To understand their interaction and characterize the binding mechanism between groove and intercalation modes, we used various spectroscopic tools. Fluorescence quenching, time-resolved emission, steady state anisotropy technique, ethidium bromide (EtBr), and 4′,6-diamidino-2-phenylindole (DAPI) displacement assays provided us biophysical aspects of IMQ-DNA interactions. All the above studies revealed the binding mode as intercalation mechanism. Circular Dichroism (CD) also well corroborated the intercalation of IMQ into DNA. Thermodynamic parameters of these binding interactions were interpreted with the help of temperature dependent spectroscopic studies characterizing the interaction as enthalpy driven. Further, the binding interactions is explored with the help of molecular docking studies. Based on experimental and computational studies it was concluded that the drug binds to DNA via intercalation mode in AT-rich DNA sequences. These biophysical investigations not only improve our comprehension of IMQ's therapeutic effectiveness but also clarifies the sequence dependent binding processes underlying comparable drug-DNA interactions.
Published: 2024

19. Recent radiation protection activities related to nuclear facilities on the Iberian Peninsula

Author: Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya. IONHE - Ionising Radiation, Health and Environment, Sáez Muñoz, Marina, Cerezo Fernández, Agustín, Prieto Butillé, Elena, Salvadó Artells, Marçal, Vildosola Hernandez, Iñigo, Duch Guillen, María Amor, Camp Brunés, Anna, Gallego Díaz, Eduardo Florentino, Gonzalez Cadelo, Juan, Verdu Martin, Gumersindo, Universitat Politècnica de Catalunya. Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya. IONHE - Ionising Radiation, Health and Environment, Sáez Muñoz, Marina, Cerezo Fernández, Agustín, Prieto Butillé, Elena, Salvadó Artells, Marçal, Vildosola Hernandez, Iñigo, Duch Guillen, María Amor, Camp Brunés, Anna, Gallego Díaz, Eduardo Florentino, Gonzalez Cadelo, Juan, and Verdu Martin, Gumersindo
Abstract: Part of the radiation protection in Spain and Portugal is focused on the protection of workers, public and environment due to the influence of nuclear facilities present in their territory (Spanish case) or nearby. Radiation protection is in a process of continuous improvement, with the participation of nuclear facilities, companies and researchers in numerous research projects funded in Spain by the Nuclear Safety Council or other international organizations. This article presents some of the projects in which Spanish working groups have participated. In addition, specific examples of activities related to radiation protection and environmental radiological monitoring carried out in Spain in recent years are shown. Among them are: the development of methods of analysis of environmental samples in case of emergency, real-time monitoring networks for measuring radiation, environmental dosimetry in the environment of nuclear facilities, programs and models of radiation dispersion in case of accident, and the treatment and management of radioactive waste for its clearance., The authors are grateful to the Valencian Agency for Security and Emergency and the Generalitat Valenciana for their support in the “Convenio de colaboración entre la Agencia Valenciana de Seguridad y Respuesta a las Emergencias y la Universitat Politècnica de València para el Desarrollo del Plan de Vigilancia Radiológica en Emergencias”. Also thank to the European Union (FEDER) for their support through the RADNATURA project (IDIFEDER/2021/047) “Assessment, control and mitigation of natural radiation sources”, and the Generalitat Valenciana for their support in the project “Evaluación del impacto radiológico debido a la presencia de material radiactivo en suspensión en actividades de la industria cerámica valenciana” (CIAICO/2021/290)., Objectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminant, Objectius de Desenvolupament Sostenible::9 - Indústria, Innovació i Infraestructura, Objectius de Desenvolupament Sostenible::3 - Salut i Benestar, Postprint (published version)
Published: 2024

20. Structural transformation of carbon-encapsulated core-shell CoNi nanoparticles during magnetically induced CO2 reduction into CO

Author: Agencia Estatal de Investigación (España), Ministerio de Ciencia y Tecnología (España), Universidad Politécnica de Valencia, Universidad de Sevilla, European Commission, Junta de Andalucía, Cerezo-Navarrete, Christian, Marin, Irene Mustieles, Marini, Carlo, Chaudret, Bruno, Martínez-Prieto, Luis M., Agencia Estatal de Investigación (España), Ministerio de Ciencia y Tecnología (España), Universidad Politécnica de Valencia, Universidad de Sevilla, European Commission, Junta de Andalucía, Cerezo-Navarrete, Christian, Marin, Irene Mustieles, Marini, Carlo, Chaudret, Bruno, and Martínez-Prieto, Luis M.
Abstract: Controlling product distribution in CO2 hydrogenation is of great scientific interest, the selective CO production through the reverse water-gas shift reaction (RWGS) being one of the most investigated processes. Herein, we report the synthesis of new core-shell Co@Ni NPs encapsulated in carbon (Co@Ni@C) to prevent their aggregation at the high-temperatures reached during magnetically induced catalysis. This bifunctional system has been simultaneously used as heating agent and catalyst for the magnetically induced hydrogenation of CO2. While at low magnetic fields Co@Ni@C produces CH4:CO mixtures, at higher field amplitudes it selectively generates carbon monoxide. Indeed, Co@Ni@C has shown to be one of the most active catalysts reported to date, which reaches a maximum conversion of 74.2% with complete selectivity towards CO at 53 mT and 300 kHz. In addition, recycling and cyclability experiments have demonstrated that Co@Ni@C becomes fully selective for CO after being exposed to high field amplitudes (i.e. reaction temperature above 500 °C), even when it exposed to low magnetic fields again. This change in the selectivity is due to an atomic rearrangement of the core-shell structure, as was confirmed by EDX, XAS, TPR and TPD analysis.
Published: 2024

21. Low-Dose Radiation Therapy in the Management of Coronavirus Disease 2019 (COVID-19) Pneumonia (LOWRAD-Cov19): Preliminary Report

Author: Noelia Sanmamed, Alcántara Carrió, María Del Pino, Elena Cerezo, Gaztañaga Boronat, Miren, Cabello Clotet, Noemí, Sara Gómez, Bustos García De Castro, Ana María, Mercedes Duffort, Anxela Doval, Corona Sánchez, Juan Antonio, Gabriel Rodriguez, Ortuño Andériz, Francisco, Castro Fernández, Javier De, Manuel Enrique Fuentes, Alvaro Sanz, Amanda López, Pérez Vázquez, José Manuel, Noelia Sanmamed, Alcántara Carrió, María Del Pino, Elena Cerezo, Gaztañaga Boronat, Miren, Cabello Clotet, Noemí, Sara Gómez, Bustos García De Castro, Ana María, Mercedes Duffort, Anxela Doval, Corona Sánchez, Juan Antonio, Gabriel Rodriguez, Ortuño Andériz, Francisco, Castro Fernández, Javier De, Manuel Enrique Fuentes, Alvaro Sanz, Amanda López, and Pérez Vázquez, José Manuel
Abstract: PubMed Disclaimer, Purpose: Low-dose radiation therapy (LD-RT) has been shown to have an anti-inflammatory effect, and preliminary results suggest it is feasible to treat patients with coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: We conducted a prospective, single-arm, phase 1/2 clinical trial enrolling patients aged ≥50 years, who were coronavirus disease 2019 (COVID-19) positive, at phase 2 or 3 with lung involvement at imaging study and oxygen requirement. Patients received 100 cGy to total lungs in a single fraction. Primary outcome was radiologic response using severity and extension score on baseline computed tomography (CT), at days 3 and 7 after LD-RT. Secondary outcomes were toxicity using Common Terminology Criteria for Adverse Events v.5.0, duration of hospitalization, blood work evolution, and oxygen requirements using SatO2/FiO2 index (SAFI), at days 3 and 7 after LD-RT. Results: Nine patients were included. Median age was 66 (interquartile range, 57-77). Severity score was stable or decreased in the third CT but was not statistically significant (P = .28); however, there were statistically significant changes in the extension score (P = .03). SAFI index significantly improved 72 hours and 1 week after LD-RT (P = .01). Inflammatory blood parameters decreased 1 week after RT compared with baseline; only lactate dehydrogenase decreased significantly (P = .04). Two patients presented grade 2 lymphopenia after RT and another (with baseline grade 3) worsened to grade 4. Overall, the median number of days of hospitalization was 59 (range, 26-151). After RT the median number of days in the hospital was 13 (range, 4-77). With a median follow-up after RT of 112 days (range, 105-150), 7 patients were discharged and 2 patients died, 1 due to sepsis and the other with severe baseline chronic obstructive pulmonary disease from COVID-19 pneumonia. Conclusions: Our preliminary results show that LD-RT was a feasible and well-tolerated treatment, with potential cl, Depto. de Radiología, Rehabilitación y Fisioterapia, Fac. de Medicina, Universidad Complutense de Madrid, TRUE, pub
Published: 2024

22. Ethanol Tolerance and Production by Yeasts

Author: Garrigues, Sandra, primary and Salazar-Cerezo, Sonia, additional
Published: 2021
Full Text: View/download PDF

23. Enteral Nutrition

Author: LeLeiko, Neal S., primary, Shapiro, Jason M., additional, Cerezo, Carolina S., additional, and Pinkos, Beth A., additional
Published: 2021
Full Text: View/download PDF

24. Contributors

Author: A-Kader, H. Hesham, primary, Abdulhai, Sophia, additional, Abu-Elmagd, Kareem, additional, Abu-El-Haija, Maisam, additional, Adler, Douglas G., additional, Albenberg, Lindsey, additional, Alonso, Estella M., additional, Amin, Ruchi, additional, Atay, Orhan, additional, Auricchio, Renata, additional, Baker, Robert D., additional, Baker, Susan S., additional, Baldwin, Katherine, additional, Barry, Jessica, additional, Baron, Todd H., additional, Barth, Bradley, additional, Bass, Dorsey M., additional, Bass, Lee M., additional, Belkind-Gerson, Jaime, additional, Benninga, Marc A., additional, Bhesania, Natalie, additional, Bischoff, Andrea, additional, Bitton, Samuel, additional, Blanchard, Samra S., additional, Bousvaros, Athos, additional, Boyle, Brendan, additional, Brewer, Jennifer, additional, Brownell, Jefferson N., additional, Bruch, Steven W., additional, Campbell, Brendan T., additional, Campbell, Jacob, additional, Caty, Michael Gerard, additional, Cerezo, Carolina S., additional, Chagpar, Ryaz, additional, Chatfield, Beth, additional, Cherry, Rebecca N., additional, Cohen, Gail, additional, Cohen, Mitchell B., additional, Coran, Arnold G., additional, Costa, Guilherme, additional, Cresci, Gail A.M., additional, Crowley, Eileen, additional, Cruise, Michael, additional, Czinn, Steven J., additional, Davidovics, Zev, additional, Torre, Luis De La, additional, DeRoss, Anthony L., additional, Devadason, David, additional, Venkatesh, Rajitha Devadoss, additional, Di Lorenzo, Carlo, additional, Dotson, Jennifer L., additional, Ediger, Tracy R., additional, Eghtesad, Bijan, additional, Eisses, John F., additional, El Yousif, Mounif, additional, McBride Emerick, Karan, additional, Erdman, Steven H., additional, Fawaz, Rima, additional, Feldstein, Ariel E., additional, Fernandes, Melissa, additional, Finn, Laura S., additional, Fiorino, Kristin Nicole, additional, Fishman, Douglas S., additional, Friedlander, Joel A., additional, Fujiki, Masato, additional, Fung, John, additional, Fuss, Ivan, additional, Galloway, David, additional, George, Donald E., additional, Ghishan, Fayez K., additional, Girlanda, Raffaelle, additional, Gitt, Donna, additional, Goldman, Deborah A., additional, Goodine, Sue, additional, Gourley, Glenn R., additional, Green, Nicole, additional, Grisotti, Gabrielle, additional, Gupta, Sandeep K., additional, Hadzic, Nedim, additional, Harpavat, Sanjiv, additional, Hashimoto, Koji, additional, Hassan, Maheen, additional, Heubi, James E., additional, Husain, Sohail Z., additional, Hussey, Séamus, additional, Hyams, Jeffrey S., additional, Hyer, Warren, additional, Hyman, Paul E., additional, Iben, Sabine, additional, Issac, Veronica E., additional, Jonas, Maureen M., additional, Kay, Marsha, additional, Kehar, Mohit, additional, Kelly, Deidre, additional, Kovacic, Karlo, additional, Kunisaki, Shaun Michael, additional, Kurowski, Jacob A., additional, Langer, Jacob C., additional, Lee, Frances C., additional, Lee, Rose, additional, LeLeiko, Neal S., additional, Liacouras, Chris A., additional, Lin, Henry, additional, Liu, Quin Y., additional, Loomes, Kathleen M., additional, Lu, Peter L., additional, Lusman, Sarah Shrager, additional, Mack, Cara, additional, Maheshwari, Anshu, additional, Mamula, Petar, additional, Manfredi, Michael A., additional, Markowitz, James F., additional, Markowitz, Jonathan E., additional, Mascarenhas, Maria R., additional, Mayer, Ryann, additional, McKiernan, Patrick, additional, Mezoff, Adam G., additional, Mezoff, Ethan A., additional, Mieli-Vergani, Giorgina, additional, Mohr, Franziska, additional, Mokha, Jasmeet, additional, Mousa, Hayat, additional, Moye, Lindsay, additional, Murch, Simon, additional, Murray, Karen F., additional, Naples, Robert, additional, Nathan, Jaimie D., additional, Lee Ng, Vicky, additional, Nguyen, Vi, additional, Nurko, Samuel, additional, Oauhed, Jodie, additional, Ogholikhan, Tina, additional, Oldham, Keith T., additional, Osman, Mohammed, additional, Ovchinsky, Nadia, additional, Panganiban, Jennifer, additional, Pena, Alberto, additional, Petras, Robert E., additional, Pfefferkorn, Marian D., additional, Piccoli, David, additional, Piester, Travis, additional, Pinkos, Beth, additional, Plesec, Thomas, additional, Polites, Stephanie, additional, Ponsky, Todd, additional, Rader, Christine, additional, Radhakrishnan, Kadakkal, additional, Reissis, Yannis, additional, Rodriguez, Leonel, additional, Rodriguez, Ricardo J., additional, Rojas, Isabel, additional, Rome, Ellen S., additional, Rosh, Joel R., additional, Ruiz, Rachel M., additional, Sahn, Benjamin, additional, Saleem, Atif, additional, Samela, Kate A., additional, Santucci, Neha R., additional, Saps, Miguel, additional, Sato, Eleanor H., additional, Sato, Thomas T., additional, Savage, Erica C., additional, Seifarth, Federico G., additional, Conjeevaram Selvakumar, Praveen Kumar, additional, Shapiro, Jason, additional, Siperstein, Allan E., additional, Skelton, Joseph, additional, Snapper, Scott, additional, Soldes, Oliver S., additional, Sood, Manu R., additional, Stahl, Marisa Gallant, additional, Sundaram, Shikha S., additional, Sylvester, Francisco A., additional, Teitelbaum, Jonathan E., additional, Terry, Natalie A., additional, Townsend, Peter, additional, Troncone, Riccardo, additional, Vance, Kate, additional, Vandenplas, Yvan, additional, Venick, Robert S., additional, Vitale, David S., additional, Vockley, Jerry, additional, Vortia, Eugene, additional, Vriesman, Mana H., additional, Wahbeh, Ghassan T., additional, Walsh, R. Matthew, additional, Warner, Suz, additional, Wyllie, Robert, additional, Yasuda, Jessica L., additional, Zeiter, Donna, additional, and Zheng, Hengqi (Betty), additional
Published: 2021
Full Text: View/download PDF

25. Deconstructing non-carious cervical lesions on teeth in forensic contexts

Author: Cerezo-Román, Jessica I., primary and Anderson, Bruce, additional
Published: 2020
Full Text: View/download PDF

26. Microglia-mediated neuroinflammation and Mediterranean diet

Author: Hornedo-Ortega, Ruth, primary, de Pablos, Rocío M., additional, Cerezo, Ana B., additional, Richard, Tristan, additional, Garcia-Parrilla, M. Carmen, additional, and Troncoso, Ana M., additional
Published: 2020
Full Text: View/download PDF

27. Contributors

Author: Anderson, Bruce, primary, Baiges-Sotos, Laura, additional, Becam, Gaël, additional, Benazzi, Stefano, additional, Bitariho, Robert, additional, Blumenthal, Scott, additional, Bromage, Timothy G., additional, Cerezo-Román, Jessica I., additional, Constantino, Paul J., additional, Crane, Adam, additional, Cranfield, Michael R., additional, Da-Gloria, Pedro, additional, D'Anastasio, Ruggero, additional, de Lumley, Marie-Antoinette, additional, Droke, Jessica L., additional, El Zaatari, Sireen, additional, Estalrrich, Almudena, additional, Fiorenza, Luca, additional, Foster, Frederick R., additional, Galbany, Jordi, additional, Grine, Frederick E., additional, Haas, Randy, additional, Kaleme, Prince, additional, Kane, Erin E., additional, Karriger, Whitney M., additional, Kelly, Christa D., additional, Kullmer, Ottmar, additional, Lee-Thorp, Julia, additional, L'Engle Williams, Frank, additional, McFarlin, Shannon C., additional, Mudakikwa, Antoine, additional, Robbins, Martha M., additional, Rwetsiba, Aggrey, additional, Schmidt, Christopher W., additional, Smith, Fred H., additional, Sponheimer, Matt, additional, Stoinski, Tara S., additional, Teaford, Mark F., additional, Tuyisingize, Deogratias, additional, Twahirwa, Jean Claude, additional, Ungar, Peter S., additional, van der Merwe, Nikolaas J., additional, Van Sessen, Rebecca, additional, Watson, James T., additional, and Yang, Deming, additional
Published: 2020
Full Text: View/download PDF

28. Contributors

Author: Abete, Itziar, primary, Aboussaleh, Youssef, additional, Accardi, Giulia, additional, Aiello, Anna, additional, Alkhatib, Ahmad, additional, Alves Castro, Inar, additional, Andújar, Isabel, additional, Antonopoulou, Smaragdi, additional, Arsic, Aleksandra, additional, Arvanitidou, Eirini-Iro, additional, Assaf-Balut, Carla, additional, Barabash, Ana, additional, Barbagallo, Mario, additional, Bastida, Sara, additional, Beccari, Giovanni, additional, Benedí, Juana, additional, Bentrad, Najla, additional, Bernal-Lopez, M. Rosa, additional, Bonaccio, Marialaura, additional, Bonanni, Americo, additional, Bordiú, Elena, additional, Bottalico, Francesco, additional, Boutopoulou, Barbara, additional, Buscemi, Silvio, additional, Calle-Pascual, Alfonso Luis, additional, Cámara, Montaña, additional, Candore, Giuseppina, additional, Capone, Roberto, additional, Caputo, Marina, additional, Cardone, Gianluigi, additional, Caruso, Calogero, additional, Caso, Giulia, additional, Castro-Quezada, Itandehui, additional, Cebadera-Miranda, Laura, additional, Cerezo, Ana B., additional, Corleo, Davide, additional, Corrêa, Rúbia C.G., additional, Covarelli, Lorenzo, additional, Czarczyńska-Goślińska, Beata, additional, Davinelli, Sergio, additional, del Valle, Laura, additional, Delgado-Andrade, Cristina, additional, Demetriou, Christiana A., additional, Detopoulou, Paraskevi, additional, Di Gioia, Francesco, additional, Diamantopoulos, E.J., additional, Dominguez, Ligia J., additional, Donati, Maria Benedetta, additional, Douros, Konstantinos, additional, Durán, Alejandra, additional, El Bilali, Hamid, additional, El Kinany, Khaoula, additional, El Rhazi, Karima, additional, Ergoren, Mahmut Cerkez, additional, De Feo, Vincenzo, additional, Ferreira, Isabel C.F.R., additional, Formica, Melissa, additional, Fragopoulou, Elizabeth, additional, Fratianni, Florinda, additional, de Gaetano, Giovanni, additional, Gaforio, José J., additional, Galarregui, Cristina, additional, Gallardo-Escribano, Cristina, additional, Galozzi, Paola, additional, Galvano, Fabio, additional, Garces-Martin, Maria, additional, Garcia-Larsen, Vanessa, additional, Garcia-Parrilla, M. Carmen, additional, Garcimartín, Alba, additional, Geliebter, Jan, additional, George, Elena S., additional, Georgousopoulou, Ekavi N., additional, Gesteiro, E., additional, Gkiouras, Konstantinos, additional, Gómez-Pérez, Ana María, additional, Goulis, Dimitrios G., additional, Gouveri, E., additional, Grammatikopoulou, Maria G., additional, Hadjisavvas, Andreas, additional, Hamida-Ferhat, Asma, additional, Hardman, Roy J., additional, Hornedo-Ortega, Ruth, additional, Iacoviello, Licia, additional, Iriti, Marcello, additional, Jeszka-Skowron, Magdalena, additional, Kakkoura, Maria G., additional, Karras, Spyridon N., additional, Knox, E., additional, Kotsa, Kalliopi, additional, Koufakis, Theocharis, additional, Koumpagioti, Despina, additional, Kyriacou, Kyriacos, additional, de la Torre, Nuria García, additional, Lampropoulou, Maria, additional, Loizidou, Maria A., additional, De Lorenzo, Antonino, additional, Macho-González, Adrián, additional, Magriplis, Emmanuella, additional, Marakomichelakis, G., additional, Martínez, J. Alfredo, additional, De Martino, Laura, additional, Medina, F. Xavier, additional, Mellor, Duane D., additional, Menotti, Alessandro, additional, Mesías, Marta, additional, Molina-Vega, María, additional, Morales, Patricia, additional, Moreno, Juan A., additional, Muros, J.J., additional, Nazzaro, Filomena, additional, Nomikos, Tzortzis, additional, Oliviero, Francesca, additional, Ottomano Palmisano, Giovanni, additional, de Pablos, Rocío M., additional, Panagiotakos, Demosthenes B., additional, Papandreou, Christopher, additional, Petropoulos, Spyridon A., additional, Prodam, Flavia, additional, Puddu, Paolo Emilio, additional, Punzi, Leonardo, additional, Quiles, José L., additional, Ramirez-Perez, Cristina, additional, Ramirez-Tortosa, Cesar L., additional, Ramírez-Tortosa, MCarmen, additional, Richard, Tristan, additional, Ricotti, Roberta, additional, Ríos, José-Luis, additional, Rodríguez-García, Carmen, additional, Román-Viñas, Blanca, additional, Ros, Emilio, additional, Rubio, Miguel Angel, additional, Ruiz-Moreno, M. Isabel, additional, Sacerdote, Carlotta, additional, Salas-Salvadó, Jordi, additional, Sánchez-Muniz, Francisco J., additional, Sánchez-Quesada, Cristina, additional, Scapagnini, Giovanni, additional, Scolaro, Bianca, additional, Seiquer, Isabel, additional, Serra-Majem, Lluís, additional, Sfriso, Paolo, additional, Spinella, Paolo, additional, Theodoridis, Xenophon, additional, Tinahones, Francisco J., additional, Tini, Francesco, additional, Tiwari, Raj, additional, Tranidou, Antigoni, additional, Troncoso, Ana M., additional, Tsofliou, Fotini, additional, Tuncel, Gulten, additional, Valerio, Johanna, additional, Varoni, Elena Maria, additional, Vilches-Perez, Alberto, additional, Vineis, Paolo, additional, Vitalini, Sara, additional, Zalvan, Craig H., additional, Zampelas, Antonis, additional, Zebekakis, Pantelis, additional, and Zulet, M. Angeles, additional
Published: 2020
Full Text: View/download PDF

29. List of Contributors

Author: Aguzzi, Carola, primary, Babu, Bathula, additional, Borrego-Sánchez, Ana, additional, Carazo, Esperanza, additional, Cerezo, Pilar, additional, Chang, Po-Hsiang, additional, Chmielewská, Eva, additional, Daković, Aleksandra, additional, Datta, Samar C., additional, de Gennaro, Bruno, additional, Dondi, Michele, additional, García-Villén, Fátima, additional, Gatta, G. Diego, additional, Gil, Antonio, additional, Jiang, Wei-Teh, additional, Krajišnik, Danina, additional, Kumararaja, Periyamuthu, additional, Li, Zhaohui, additional, Lotti, Paolo, additional, Manjaiah, Kanchikeri M., additional, Marković, Marija, additional, Milić, Jela, additional, Misaelides, Panagiotis, additional, Molinari, Chiara, additional, Mukhopadhyay, Raj, additional, Naveen, Shivalingegowda, additional, Paul, Ranjan, additional, Raghu, Anjanapura V., additional, Ravindranadh, Koutavarapu, additional, Reddy, Kakarla R., additional, Rusmin, Ruhaida, additional, Sánchez-Espejo, Rita, additional, Sarkar, Binoy, additional, Ugochukwu, Uzochukwu C., additional, Venkata Reddy, Ch., additional, Vicente, Miguel A., additional, Viseras, César, additional, and Zanelli, Chiara, additional
Published: 2019
Full Text: View/download PDF

30. List of Contributors

Author: Agarwal, Charu, primary, Akturk, Omer, additional, Albers, Rebecca Faggion, additional, Andronescu, Ecaterina, additional, Arcos, D., additional, Balanc, Bojana, additional, Batra, Sonali, additional, Bugarski, Branko, additional, Csóka, Levente, additional, da Silva, Mônica Freitas, additional, da Silva, Tiago Luis, additional, de Jesus, Marcelo Bispo, additional, de Moraes, Daniel Angeli, additional, de Queiróz, Daniely Ferreira, additional, de Souza, Caio Guilherme Secco, additional, Erdemli, Ozge, additional, Fang, Ruina, additional, Florea, Denisa-Alexandra, additional, Gómez-Cerezo, N., additional, Grumezescu, Alexandru Mihai, additional, Grumezescu, Valentina, additional, Hatami, Mohammad, additional, Heeg, Jan, additional, Hryniewicz, Tadeusz, additional, Jose, Ajith James, additional, Kellomäki, Minna, additional, Kordas, Krisztian, additional, Kumar, Kuldeep, additional, Levic, Steva, additional, Liu, Wei, additional, Lorite, Gabriela Simone, additional, Ma, Jinju, additional, Malavika, C., additional, Malorny, Winfried, additional, Mendonça, Monique Culturato Padilha, additional, Milivojevic, Milan, additional, Mohl, Melinda, additional, Nedovic, Viktor, additional, Neves, Herbert Rodrigo, additional, Owaid, Mustafa Nadhim, additional, Pajic-Lijakovic, Ivana, additional, Perecin, Caio José, additional, Pitkänen, Olli, additional, Radosevic, Radenko, additional, Rawat, Shweta, additional, Rokosz, Krzysztof, additional, Saxena, Jyoti, additional, Schütz, Antje, additional, Sharma, Sumit, additional, Singh, Apoorva, additional, Singh, Rupinder, additional, Singh, Sunpreet, additional, Souza Junior, João Batista, additional, Stepczyńska, Magdalena, additional, Stevanovic-Dajic, Zora, additional, Tapio Koivisto, Janne, additional, Thomas, Paulose, additional, Trifkovic, Kata, additional, Tunali, Beste Cagdas, additional, Vallet-Regí, M., additional, Varanda, Laudemir Carlos, additional, Verma, Neelam, additional, Wienecke, Marion, additional, and Yao, Xinding, additional
Published: 2019
Full Text: View/download PDF

31. Mesoporous bioactive glasses for biomedical composites

Author: Gómez-Cerezo, N., primary, Arcos, D., additional, and Vallet-Regí, M., additional
Published: 2019
Full Text: View/download PDF

32. Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

Author: Polo, Lorena, Gomez Cerezo, Natividad, Vivancos, Jose Luis, Sancenón, Félix, Arcos, Daniel, Vallet Regí, María, Martínez Máñez, Ramón, Polo, Lorena, Gomez Cerezo, Natividad, Vivancos, Jose Luis, Sancenón, Félix, Arcos, Daniel, Vallet Regí, María, and Martínez Máñez, Ramón
Abstract: RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí), Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and e-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic(levofloxacin) and an antitumoral drug(doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments. Statement of Significance Molecular-gated materials have recently been drawing attention due to their applications in fields as biomedicine and molecular recognition. For the first time as we are aware, we report herein a new enzymatic responsive molecular-gated device consisting in a mesoporous bioactive glass support implemented with two different molecular gates. Both controlled drug delivery properties and apatite-like phase formation ability of the device have been demonstrated, getting promising results. This approach opens up the possibility of developing new stimuli-responsive tailored biomaterials for bone cancer and infection treatments as well as regenerative bone grafts., Unión Europea. H2020, Ministerio de Ciencia e Innovación (MICINN), Generalitat Valenciana, CIBER-BBN, Universitat Politècnica de València, Depto. de Química en Ciencias Farmacéuticas, Fac. de Farmacia, TRUE, inpress
Published: 2023

33. Effect of green infrastructures supported by adaptative solar shading systems on livability in open spaces

Author: Álvarez Domínguez, Servando, Sánchez Ramos, José, Universidad de Sevilla. Departamento de Ingeniería Energética, Universidad de Sevilla. TEP143: Termotecnia, European Commission Grant Agreement LIFE18 CCA/ES/001122, Andalusian Government Grant Agreement US.20–15, Palomo Amores, Teresa Rocío, Guerrero Delgado, María del Carmen, Castro Medina, Daniel, Cerezo-Narváez, Alberto, Álvarez Domínguez, Servando, Sánchez Ramos, José, Universidad de Sevilla. Departamento de Ingeniería Energética, Universidad de Sevilla. TEP143: Termotecnia, European Commission Grant Agreement LIFE18 CCA/ES/001122, Andalusian Government Grant Agreement US.20–15, Palomo Amores, Teresa Rocío, Guerrero Delgado, María del Carmen, Castro Medina, Daniel, and Cerezo-Narváez, Alberto
Abstract: Lack of thermal comfort in the existing building stock in many warm summer climates and the COVID-19 pandemic have increased residents' temporary occupation of urban open spaces. However, climate change and other effects such as urban heat islands are also negatively affecting the livability of these spaces. Therefore, strategies are needed to improve the thermal conditions in these areas. In this context, the research designs, simulates and assesses an urban green infrastructure supported by an adaptative solar shading system. For this purpose, a public square to be renovated in Seville (Spain) is chosen. After an analysis of the current situation, more vegetation is added. However, trees are not planted fully grown, so their cover is not enough in the short term and an artificial system that protects from the sun by casting shade and that adapts to both their growth and the seasons is included. The urban space is characterized by on-site measurements, proposing four (initial, intermediates and final) scenarios using computational fluid dynamics simulations in an holistic microclimate modelling system. In turn, changes in thermal comfort are analyzed using the COMFA model. Results show that the air and surface temperature are decreased, reducing the number of hours in discomfort by 21% thanks to incorporating the green structure and by 30% due to the vegetation. It can be concluded that the use of these temporary urban prostheses enables urban spaces regenerated with vegetation to be enjoyed without waiting 20 or 30 years for the trees to mature, encouraging people to spend more time outdoors from the start of the intervention.
Published: 2023

34. Spatio-chromatic vision with multifocal diffractive intraocular lens

Author: Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge, Millán Garcia-Varela, M. Sagrario, Clavé Cerezo, Laura, Torrents Gómez, Aurora, Armengol Cebrian, Jesús, Vega Lerín, Fidel, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge, Millán Garcia-Varela, M. Sagrario, Clavé Cerezo, Laura, Torrents Gómez, Aurora, Armengol Cebrian, Jesús, and Vega Lerín, Fidel
Abstract: Background This study aims to detect alterations in the spatio-chromatic pseudophakic vision produced by multifocal diffractive intraocular lenses (IOLs) and provides a physical interpretation. Methods In vitro characterization of the imaging performance of two diffractive IOLs: AT LISA Tri (Zeiss) and FineVision (PhysIOL) in on-bench model eye illuminated with red (R, 625 nm), green (G, 530 nm) and blue (B, 455 nm) lights. We used the metrics: energy efficiency (EE), area under the modulation transfer function, longitudinal chromatic aberration (LCA), and halo intensity. Through-focus (TF) analysis and calculation of the expected defocus curve under white (W) daylight were included. In vivo visual acuity (VA) of 50 pseudophakics (60 eyes) was assessed under W, R, G, B lights at far and near. Two clinical experiments evaluated LCA and R, G, B TF-EE effects on pseudophakic vision and their relative importance. Results Clinical mean VA values under W light agreed with the predicted values at far and near for both IOLs. LCA measurements and R, G, B TF-EE curves were consistent with their lens design based on the 0th and 1st diffraction orders operative for far and near vision, respectively. LCA effects were compensated at near but noticed at far (-¿0.75 D under B light). We detected strong asymmetry in visual resolution depending on the object distance and the illuminating wavelength—red predominance at far, blue predominance at near—in consistency with the TF-EE measurements. Conclusions Diffractive multifocal IOL designs produce asymmetries in the spatio-chromatic vision of pseudophakics beyond the alterations strictly due to LCA. VA asymmetry for far/near object distance under R and B illumination is clinically detectable in subjects implanted with IOLs with 0th and 1st diffraction orders for far and near vision, respectively. Such VA asymmetry cannot be explained solely from the influence of defocus, as would be derived from a chromatic difference of power, but mai, Agencia Estatal de Investigación from Spanish Government (Grant No. PID2020-114582RB-I00/AEI/10. 13039/501100011033)., Peer Reviewed, Postprint (published version)
Published: 2023

35. Uncertainty modeling in electrical power engineering: robust optimization

Author: Raquel García-Bertrand, Luis Baringo, and Álvaro García-Cerezo
Published: 2023

36. Introduction to probability theory

Author: Raquel García-Bertrand, Luis Baringo, and Álvaro García-Cerezo
Published: 2023

37. List of contributors

Author: Shilpi Agarwal, Faheem Ahmed, Shefali Arora, Jaspreet Singh Aulakh, Richa Bhardwaj, Adrian Iulian Borhan, Ranjeet Kumar Brajpuriya, Georgiana Bulai, Ovidiu Florin Caltun, Daniela Carta, Maria F. Casula, Keun Hwa Chae, Edson Ferreira Chagas, Surjeet Chahal, Prakash Chand, Vishnu Chauhan, Anna Corrias, Gopal Datt, Ksh. Devarani Devi, Seema Devi, Archana Dhyani, Reena Dhyani, Ioan Dumitru, G.D. Dwivedi, A. Espinosa, Edson Silva Ferreira, Karsten Fleischer, Mohammad Reza Ganjali, Daniel Gherc, D. Gómez-Cerezo, Navdeep Goyal, Manjeet Singh Goyat, Deepika Gupta, Tejendra K. Gupta, Essia Hannachi, Mohd Hashim, Clare Hoskins, Sajid Husain, Alexandra Raluca Iordan, M. Jayasimhadri, Jayant Jogi, Amit Joshi, Deepika P. Joshi, S.K. Joshi, Asokan Kandasami, Baljeet Kaur, Abhimanyu Singh Khichi, B.H. Koo, Branko Koprivica, Akshay Kumar, Ankit Kumar, Ashok Kumar, Hemaunt Kumar, Manish Kumar, Parmod Kumar, Promod Kumar, Rajesh Kumar, Shalendra Kumar, Kavita Kumari, Mamta Latwal, Weon C. Lim, Danilo Loche, R. López-Méndez, C. Lozano-Pedraza, Keyvan Malaie, Bella Manshian, Mohan Chandra Mathpal, Jero Maze, Gavin Mountjoy, Manash Protim Mudoi, Daragh Mullarkey, Subhajit Nandy, Razia Nongjai, Adeolu Oluwasamni, Daniel Ortega, J. Ortega-Juliá, Vinod K. Paidi, Mircea Nicolae Palamaru, Ganesh Panday, S. Pavithra, Christophe Prigent, Sunita Rani, G. Ravi, M.V. Reddy, A. Sakunthala, Antonio Santana-Otero, E. Sanz-de Diego, S. Shankar, Aditya Sharma, Ram K. Sharma, Sonia Sharmin, Igor V. Shvets, Jitendra Pal Singh, Lalit Singh, Varsha Singh, S.K. Singhal, Shailey Singhal, Yassine Slimani, Stefaan Soenen, Maria A.G. Soler, Ramesh Chandra Srivastava, Sébastien Steydly, null Suman, H.C. Swart, F.J. Teran, O.P. Thakur, Elena Vasilica Trandafir, Martino Trassinelli, Garima Vashisht, Dominique Vernhet, Ankush Vij, and R. Yuvakumar
Published: 2023

38. Uncertainty modeling in electrical power engineering: stochastic programming

Author: Raquel García-Bertrand, Luis Baringo, and Álvaro García-Cerezo
Published: 2023

39. Ferrite nanoparticles for hyperthermia

Author: Santana-Otero, A., Gómez-Cerezo, D., Lozano-Pedraza, C., López-Méndez, R., Sanz-de Diego, E., Ortega-Juliá, J., Espinosa, A., Teran, F., and Ortega, D.
Published: 2023

40. Fresnel solar cooling plant for buildings: Optimal operation of an absorption chiller through inverse modelling

Author: MCarmen Guerrero Delgado, Jose Sánchez Ramos, Daniel Castro Medina, Teresa Rocío Palomo Amores, Alberto Cerezo-Narváez, Servando Álvarez Domínguez, Universidad de Sevilla. Departamento de Ingeniería Energética, and Universidad de Sevilla. TEP143: Termotecnia
Subjects: Absorption chiller, General Energy, Solar cooling plant, Inverse modelling, Renewable energy integration, Double effect
Abstract: Increasing comfort conditions in buildings imply higher energy demands. However, these needs can be mitigated by solar cooling solutions. These systems, such as absorption chillers, are complex and require stable operation, with strict control to maximise the solar fraction and minimise gas consumption. This is incompatible with the variability of renewable resources, so they are often coupled with auxiliary gas systems. Although gas-free operation is possible if these systems are optimally controlled, they would require special supervision. This paper aims to develop an experimental validation of an inverse model to manage an absorption chiller coupled with a solar cooling plant. To know its real behaviour, long-term experiments have been performed using this plant, which consists of a linear Fresnel solar collector and an auxiliary natural gas boiler. The inverse model is used as a predictive control tool to decide the auxiliary boiler commands of the absorption chiller to optimise its operation: maximum cooling production by minimising gas consumption and maximising solar contribution. It has been identified with data from two weeks and validated with data from one summer month. Results show that the model estimates, on a time base of fewer than 30 min, are acceptable with errors of less than 5%. In addition, the maximum error of the estimated seasonal COP and the renewable fraction are less than 6% per day. Therefore, the results prove the usefulness of the proposal as a predictive control for optimal operation. Furthermore, it could be used as a baseline for preventive maintenance. If the proposed model is used for optimal management of the absorption chiller, the thermal efficiency of the plant increases significantly, doubling the solar contribution. As a result, the gas consumption of the solar cooling plant is halved and the total cost of air conditioning the building decreases by 16%. Comisión Europea A_B.4.3_021
Published: 2022

41. Vinegars and Other Fermented Condiments

Author: Garcia-Parrilla, M.C., primary, Torija, M.J., additional, Mas, A., additional, Cerezo, A.B., additional, and Troncoso, A.M., additional
Published: 2017
Full Text: View/download PDF

42. List of Contributors

Author: Abriouel, H., primary, Aguilera, Y., additional, Amigo, L., additional, Beena, D.J., additional, Benítez-Páez, A., additional, Benítez, V., additional, Benomar, N., additional, Bou, R., additional, Cerezo, A.B., additional, Chung, S.H., additional, Ciesarová, Z., additional, Coda, R., additional, Cofrades, S., additional, Coton, M., additional, Curiel, J.A., additional, Daniel, N., additional, De Freitas, V., additional, de las Rivas, B., additional, Diana, M., additional, Escalante, A., additional, Esteban-Torres, M., additional, Fernandes, I., additional, Fernandez, M.A., additional, Figueroa, L.M., additional, Frias, J., additional, Gálvez, A., additional, Garcia-Parrilla, M.C., additional, Gobbetti, M., additional, Gómez-Guillén, M.C., additional, González-SanJosé, M.L., additional, Gürsoy, O., additional, Gutiérrez-Uribe, J.A., additional, Hernández-Ledesma, B., additional, Ismail, B., additional, Jeong, J.-K., additional, Jiménez-Colmenero, F., additional, Karovičová, J., additional, Kesenkaş, H., additional, Kim, D.-H., additional, Kim, H.-Y., additional, Kim, M., additional, Knapp, C.W., additional, Kohajdová, Z., additional, Landete, J.M., additional, Le Barz, M., additional, López de Felipe, F., additional, López-Caballero, M.E., additional, López-Expósito, I., additional, Magala, M., additional, Mani, V., additional, Marette, A., additional, Martín-Cabrejas, M.A., additional, Martín-del-Campo, S.T., additional, Martínez-Álvarez, O., additional, Martinez-Villaluenga, C., additional, Martín, J.F., additional, Mas, A., additional, Mateus, N., additional, Mikušová, L., additional, Ming, L.C., additional, Miralles, B., additional, Montero, P., additional, Muñoz, R., additional, Nampoothiri, K.M., additional, Özbaş, H., additional, Park, K.-Y., additional, Patel, S., additional, Peñas, E., additional, Peres, C., additional, Peres, C.M., additional, Pérez-Gregorio, R., additional, Picard-Deland, É., additional, Quílez, J., additional, Reiter, R.J., additional, Reverón, I., additional, Rizzello, C.G., additional, Rodríguez, H., additional, Rodríguez, P.M., additional, Ryan, E.P., additional, Santamaría, L., additional, Sanz, Y., additional, Schmid, A., additional, Shukla, S., additional, Simon Sarkadi, L., additional, Soares, S., additional, Surma, M., additional, Torija, M.J., additional, Troncoso, A.M., additional, Valls-Bellés, V., additional, Vasanthakumari, D.S., additional, Walther, B., additional, Wilburn, J.R., additional, Xavier Malcata, F., additional, Zielińska, D., additional, and Zieliński, H., additional
Published: 2017
Full Text: View/download PDF

43. Climate data for the European forestry sector: From end-user needs to opportunities for climate resilience

Author: Jorge Paz Jiménez, Valentino Marini Govigli, Inazio Martínez de Arano, Nieves Peña Cerezo, María Inés Romero, Siebe Briers, Marcus Lindner, Cecilia Fraccaroli, Fraccaroli C., Marini Govigli V., Briers S., Pena Cerezo N., Paz Jimenez J., Romero M., Lindner M., and Martinez de Arano I.
Subjects: Service (business), Climate services, H1-99, Atmospheric Science, Global and Planetary Change, End user, Climate change, Forestry, SWOT, User requirements document, Climate resilience, Forest risk management, Europe, Social sciences (General), User-driven requirements, Work (electrical), Meteorology. Climatology, Climate service, Copernicu, Business, QC851-999, SWOT analysis, Strengths and weaknesses, Copernicus
Abstract: The aim of this study is to assess the potential of Earth Observation and climate data for the forestry sector focusing on the Copernicus Climate Change Service (C3S). Although forestry researchers recognize the importance of Earth Observation and climate data, forestry practitioners currently work mainly with land cover information, largely neglecting climate data. Understanding its potential for the forestry sector becomes thus important, as to align the vast offer of climate services in Europe to different forestry users and stakeholders’ necessities. Interviews, surveys, and dedicated workshops were used to collect a series of forestry end-users’ needs and requirements regarding climate data. End-user’s requirements were categorized through a SWOT analysis, which allowed to identify perceived internal strengths and weaknesses, external opportunities and threats to the increased use of the C3S. Results indicate that improved climate services for the forestry sector based on C3S data would benefit from enhanced training on the use of climate data, improved provision of services integrating climate with non-climate data, the provision of new variables and indicators, and the integration of machine learning techniques for developing data and information in support of the deployment of climate services. These findings are relevant to close the gap between demand and supply of climate services for the forestry sector and provide a basis for further exploring the value of climate data in serving a wide array of forestry stakeholders. Going forward, increased knowledge on user requirements from both forest practitioners and policy-makers can be beneficial to develop accessible tailored services.
Published: 2021

44. Effectiveness of the systematic use of antimicrobial filters in the water taps of critical care units for the prevention of healthcare-associated infections with Pseudomonas aeruginosa

Author: Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Chico-Sánchez, Pablo, Gras-Valentí, Paula, Algado-Sellés, Natividad, Jiménez-Sepúlveda, Natali Juliet, Rodríguez-Díaz, Juan Carlos, Merino-Lucas, Esperanza, Galiana-Ivars, María, Fuster-Pérez, Marina, Cartagena-Llopis, Lidia, Balboa Esteve, Sonia, Cánovas-Jávega, Sandra, Esclapez-Martínez, Ana, Monerris-Palmer, Miranda, Cerezo-Millán, Patricia, Sánchez-Payá, José, Ronda-Pérez, Elena, Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia, Chico-Sánchez, Pablo, Gras-Valentí, Paula, Algado-Sellés, Natividad, Jiménez-Sepúlveda, Natali Juliet, Rodríguez-Díaz, Juan Carlos, Merino-Lucas, Esperanza, Galiana-Ivars, María, Fuster-Pérez, Marina, Cartagena-Llopis, Lidia, Balboa Esteve, Sonia, Cánovas-Jávega, Sandra, Esclapez-Martínez, Ana, Monerris-Palmer, Miranda, Cerezo-Millán, Patricia, Sánchez-Payá, José, and Ronda-Pérez, Elena
Abstract: Background: Pseudomonas aeruginosa (PA) is the third leading aetiological agent in healthcare-associated infections (HAIs) and the one most frequently found in patients with pneumonia associated with mechanical ventilation. In intensive care units (ICU), its appearance is associated with higher mortality, an increase in the days spent on ventilation, and hospital stay length and costs. Thus, evaluating strategies for preventing these infections is essential for their control. Therefore, our objective was to evaluate the effectiveness of the systematic use of antimicrobial filters in preventing PA infections in critical care units. Methods: This was an open experimental crossover study. A total of 2,156 patients admitted for more than 24 hours in critical care units were included, 1,129 of them in units with filters, and 1,027 in units without filters. The study groups were followed-up for 24 months and HAIs were checked for the presence of PA. Chi-squared test were used to compare the rate of HAIs between groups and we calculated 95% confidence intervals adjusted by Poisson regression for the rate ratio (RR) of the association magnitude. Results: Both groups were homogeneous in terms of intrinsic and extrinsic patient factors. The incidence of PA infections in the units with filters was 5.5 cases/1,000 hospitalized days and 5.4/1,000 hospitalized days for the units without water filters (RR = 1.09 [0.67-1.79]). Conclusions: Routine placing antimicrobial filters in the water taps in critical care units was not an effective means of preventing the emergence of HAIs caused by PA.
Published: 2022

45. Fresnel solar cooling plant for buildings: Optimal operation of an absorption chiller through inverse modelling

Author: Universidad de Sevilla. Departamento de Ingeniería Energética, Universidad de Sevilla. TEP143: Termotecnia, Guerrero Delgado, María del Carmen, Sánchez Ramos, José, Castro Medina, Daniel, Palomo Amores, Teresa Rocío, Cerezo-Narváez, Alberto, Álvarez Domínguez, Servando, Universidad de Sevilla. Departamento de Ingeniería Energética, Universidad de Sevilla. TEP143: Termotecnia, Guerrero Delgado, María del Carmen, Sánchez Ramos, José, Castro Medina, Daniel, Palomo Amores, Teresa Rocío, Cerezo-Narváez, Alberto, and Álvarez Domínguez, Servando
Abstract: Increasing comfort conditions in buildings imply higher energy demands. However, these needs can be mitigated by solar cooling solutions. These systems, such as absorption chillers, are complex and require stable operation, with strict control to maximise the solar fraction and minimise gas consumption. This is incompatible with the variability of renewable resources, so they are often coupled with auxiliary gas systems. Although gas-free operation is possible if these systems are optimally controlled, they would require special supervision. This paper aims to develop an experimental validation of an inverse model to manage an absorption chiller coupled with a solar cooling plant. To know its real behaviour, long-term experiments have been performed using this plant, which consists of a linear Fresnel solar collector and an auxiliary natural gas boiler. The inverse model is used as a predictive control tool to decide the auxiliary boiler commands of the absorption chiller to optimise its operation: maximum cooling production by minimising gas consumption and maximising solar contribution. It has been identified with data from two weeks and validated with data from one summer month. Results show that the model estimates, on a time base of fewer than 30 min, are acceptable with errors of less than 5%. In addition, the maximum error of the estimated seasonal COP and the renewable fraction are less than 6% per day. Therefore, the results prove the usefulness of the proposal as a predictive control for optimal operation. Furthermore, it could be used as a baseline for preventive maintenance. If the proposed model is used for optimal management of the absorption chiller, the thermal efficiency of the plant increases significantly, doubling the solar contribution. As a result, the gas consumption of the solar cooling plant is halved and the total cost of air conditioning the building decreases by 16%.
Published: 2022

46. La Cuevona de Avín (Avín, Asturias, North Spain): A new Late Pleistocene site in the lower valley of the River Güeña

Author: Principado de Asturias, Ministerio de Ciencia e Innovación (España), Fundação para a Ciência e a Tecnologia (Portugal), Álvarez-Fernández, Esteban, Martín-Jarque, Sergio, Portero, Rodrigo, Vadillo Conesa, Margarita, Martínez-Villa, Alberto, Aparicio, Teresa, Armenteros, Idelfonso, Cerezo-Fernández, Rosana, Domingo, Rafael, García-Ibaibarriaga, Naroa, González, F. Javier, Llorente, Laura, Rufà, Anna, Tarriño, Antonio, Uzquiano, Paloma, Pinto-Llona, Ana C., Principado de Asturias, Ministerio de Ciencia e Innovación (España), Fundação para a Ciência e a Tecnologia (Portugal), Álvarez-Fernández, Esteban, Martín-Jarque, Sergio, Portero, Rodrigo, Vadillo Conesa, Margarita, Martínez-Villa, Alberto, Aparicio, Teresa, Armenteros, Idelfonso, Cerezo-Fernández, Rosana, Domingo, Rafael, García-Ibaibarriaga, Naroa, González, F. Javier, Llorente, Laura, Rufà, Anna, Tarriño, Antonio, Uzquiano, Paloma, and Pinto-Llona, Ana C.
Abstract: The archaeological investigations carried out in the last twenty years in the Lower Valley of the River Güeña (Asturias, central part of northern Spain) have documented different prehistoric sites, particularly with Middle and Upper Palaeolithic occupations. This paper presents the results of the archaeological excavation carried out in the cave of La Cuevona de Avín. From the systematic study of the biotic and abiotic remains, a total of three occupation phases (Phases 1 to 3) have been determined, dated in the Late Pleistocene. The lithic studies indicate the use of local raw materials (mainly quartzite), but also regional ones (different types of flint) in the whole sequence. Retouched implements are typologically representative only during the Upper Magdalenian (Phase II) and use-wear analysis indicates the manufacture and use of artefacts in situ during this phase. Archaeozoological studies reveal continuity in subsistence strategies throughout the sequence, noting specialization in red deer hunting during the Azilian (Phase I), and more diversified prey in the older phases.
Published: 2022

47. Tomato Systemin induces resistance against Plectosphaerella cucumerina in Arabidopsis through the induction of phenolic compounds and priming of tryptophan derivatives

Author: Ministerio de Ciencia e Innovación (España), European Commission, Generalitat Valenciana, Universidad Jaime I, Pastor-Fernández, Julia, Sánchez-Bel, P., Gamir, Jordi, Pastor, Victoria, Sanmartín, N., Cerezo García, Miguel, Andrés-Moreno, S., Flors, Victor, Ministerio de Ciencia e Innovación (España), European Commission, Generalitat Valenciana, Universidad Jaime I, Pastor-Fernández, Julia, Sánchez-Bel, P., Gamir, Jordi, Pastor, Victoria, Sanmartín, N., Cerezo García, Miguel, Andrés-Moreno, S., and Flors, Victor
Abstract: Phytocytokines are endogenous danger peptides that are actively released after a pest or pathogen attack, triggering an amplification of plant immune responses. Here, we found that Systemin, a peptide from tomato, has a substantial impact at the molecular level in Arabidopsis plants that leads to induced resistance against Plectosphaerella cucumerina. Using transcriptional and metabolomics approaches, and loss-of-function mutants to analyse the molecular mechanisms underlying induced resistance against the necrotroph, we decipher the enhanced molecular responses in Systemin-treated plants following infection. Some protein complexes involved in the response to other damage signals, including the BAK1-BIK1 protein complex and heterotrimeric G proteins, as well as MPK activation, were among the early signalling events triggered by Systemin in Arabidopsis upon infection. Non-targeted analysis of the late responses underlying Systemin-Induced Resistance (Sys-IR) showed that phenolic and indolic compounds were the most representative groups in the Systemin metabolic fingerprint. Lack of flavonoids resulted in the impairment of Sys-IR. On the other hand, some indolic compounds showed a priming profile and were also essential for functional Sys-IR. Evidence presented here shows that plants can sense heterologous peptides from other species as danger signals driving the participation of common protein cascades activated in the PTI and promoting enhanced resistance against necrotrophic fungus.
Published: 2022

48. Health and Medical Applications of Tubular Clay Minerals

Author: Aguzzi, C., primary, Sandri, G., additional, Cerezo, P., additional, Carazo, E., additional, and Viseras, C., additional
Published: 2016
Full Text: View/download PDF

49. The Satisfaction with Life Scale in Breast Cancer Patients: Psychometric Properties

Author: Rafael Alarcón, María J. Blanca, M. Victoria Cerezo, and Lorena M. Soria-Reyes
Subjects: Psicología positiva, media_common.quotation_subject, Well-being, Context (language use), Optimism, Positive psychology, Bienestar social, Instrumental study, medicine, Optimismo, media_common, Florecimiento, Emotional intelligence, Flourishing, Estudio instrumental, Confirmatory factor analysis, Psicología, Clinical Psychology, Anxiety, Original Article, medicine.symptom, Psychology, Bienestar, Clinical psychology
Abstract: Background/Objective This study aims to analyze the psychometric properties of the Satisfaction with Life Scale (SWLS), examining the reliability of scale scores and providing validity evidence for its use with breast cancer patients. We provide validity evidence based on internal structure and on relationships with positive psychological variables and other variables indicative of psychological adjustment. Method Participants were 222 Spanish women with a diagnosis of breast cancer. They completed the SWLS and a battery of questionnaires measuring positive and negative affect, self-esteem, resilience, emotional intelligence, flourishing, optimism, depression, anxiety, and stress. Results Confirmatory factor analysis supported a single-factor structure for the SWLS, S-B χ2(5) = 7.36, p = .19, CFI = .99, NNFI = .99, RMSEA = .046. The reliability of test scores estimated with McDonald's omega yielded a value of .80. Validity evidence was provided by a positive correlation between SWLS scores and positive affect, self-esteem, resilience, emotional intelligence (specifically, clarity and repair), flourishing, and optimism (range: .24, .69), and by a negative correlation with negative affect, pessimism, depression, anxiety, and stress (range: -.25, -.59). Conclusions The Spanish version of the SWLS showed satisfactory psychometric properties and it is an appropriate measure for use in the breast cancer context. This research was supported by a grant from the Junta de Andalucía (Group CTS-110), and funding for open access charge: Universidad de Malaga / CBUA.This research was supported by a grant from the Junta de Andalucía (Group CTS-110), and funding for open access charge: Universidad de Malaga / CBUA.
Published: 2022

50. La Cuevona de Avín (Avín, Asturias, North Spain): A new Late Pleistocene site in the lower valley of the River Güeña

Author: Esteban Álvarez-Fernández, Sergio Martín-Jarque, Rodrigo Portero, Margarita Vadillo Conesa, Alberto Martínez-Villa, Mª Teresa Aparicio, Ildefonso Armenteros, Rosana Cerezo-Fernández, Rafael Domingo, Naroa García-Ibaibarriaga, F. Javier González, Laura Llorente, Anna Rufà, Antonio Tarriño, Paloma Uzquiano, Ana C. Pinto-Llona, Principado de Asturias, Ministerio de Ciencia e Innovación (España), and Fundação para a Ciência e a Tecnologia (Portugal)
Subjects: Archeology, Late Pleistocene, Subsistence strategies, Raw material, Technology and use-wear analysis, Cantabrian Spain
Abstract: The archaeological investigations carried out in the last twenty years in the Lower Valley of the River Güeña (Asturias, central part of northern Spain) have documented different prehistoric sites, particularly with Middle and Upper Palaeolithic occupations. This paper presents the results of the archaeological excavation carried out in the cave of La Cuevona de Avín. From the systematic study of the biotic and abiotic remains, a total of three occupation phases (Phases 1 to 3) have been determined, dated in the Late Pleistocene. The lithic studies indicate the use of local raw materials (mainly quartzite), but also regional ones (different types of flint) in the whole sequence. Retouched implements are typologically representative only during the Upper Magdalenian (Phase II) and use-wear analysis indicates the manufacture and use of artefacts in situ during this phase. Archaeozoological studies reveal continuity in subsistence strategies throughout the sequence, noting specialization in red deer hunting during the Azilian (Phase I), and more diversified prey in the older phases., It was funded by the Consejería de Asuntos Sociales e Igualdad, and authorized by the Consejería de Patrimonio, both of the Government of the Principality of Asturias. The present research was undertaken in the context of the Spanish project PID2020.114462 GB-I00 funded by the Programa Estatal de Fomento de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico, of the Spanish Ministry of Science and Innovation. Anna Rufà is currently a beneficiary of the Concurso Estímulo ao Emprego Científico Individual - 3rd Edition promoted by the Portuguese FCT (reference: 2020.00877.CEECIND).
Published: 2022

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

382 results on '"CEREZO"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources