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Antidotes to Toxins and Drugs: From Natural Sources to Drug Discovery in Toxicology presents recent advances in the discovery of natural antidotes to toxins, drug intoxications and overdoses in pharmacology, drug discovery and toxicology. The text provides detailed information about toxins and their natural antidotes, along with the identification and screening of antidotes for drug intoxications and overdoses. Written by a global team of experts, it describes the potential uses of natural products in toxicology and their applications in medicine and in the pharmaceutical sciences. This book will be a key resource for drug developers, medicinal chemists and toxicologists, among others.Sections shine a particular focus on mechanisms of action, various principles in pharmacokinetics and pharmacodynamics terms, and possible sources and synthesis techniques for these phytochemicals. - Details recent advances in the discovery of natural antidotes from medicinal plants and phytochemicals - Includes advances in the discovery of antidotes to drug intoxications and overdoses - Describes modern screening assays for toxins and drug intoxications - Features information on recent advances in toxicology

Water Security: Big Data-Driven Risk Identification, Assessment and Control of Emerging Contaminants contains the latest information on big data-driven risk detection and analysis, risk assessment and environmental health effect, intelligent risk control technologies, and global control strategy of emerging contaminants. First, this book highlights advances and challenges throughout the detection of emerging chemical contaminants (e.g., antimicrobials, microplastics) by sensors or mass spectrometry, as well as emerging biological contaminant (e.g., ARGs, pathogens) by a combination of next- and third-generation sequencing technologies in aquatic environment. Second, it discusses in depth the ecological risk assessment and environmental health effects of emerging contaminants. Lastly, it presents the most up-to-date intelligent risk management technologies. This book shares instrumental global strategy and policy analysis on how to control emerging contaminants. Offering interdisciplinary and global perspectives from experts in environmental sciences and engineering, environmental microbiology and microbiome, environmental informatics and bioinformatics, intelligent systems, and knowledge engineering, this book provides an accessible and flexible resource for researchers and upper level students working in these fields. - Covers the detection, high-throughput analyses, and environmental behavior of the typical emerging chemical and biological contaminants - Focuses on chemical and biological big data driven aquatic ecological risk assessment models and techniques - Highlights the intelligent management and control technologies and policies for emerging contaminants in water environments

Encyclopedia of the Human Brain, Second Edition, Seven Volume Set builds on the success of the first edition, providing neuroscience researchers with the ideal'one-stop'resource on all topics related to human brain understanding. Given the length of time since the first edition published, EHB2 is thoroughly revised, with substantial updates on many new and exciting topics, including areas such as human neuroimaging, non-invasive brain stimulation, molecular biology (including genetics and epigenetics), and the clinical diagnoses of brain disorders, along with chapters exploring the introduction of new theoretical and methodological ideas in areas ranging from cognitive neuroscience to evolution of the human brain. In total, there are 440 articles – a vast increase from 224 previously - thus reflecting the huge explosion in neuroscience research during the last 20 years. EHB2 provides a brand new generation of neuroscientists with the perfect tool with which to learn and master the fundamentals of how and why the human brain operates as it does. - Provides a comprehensive and up-to-date resource for exploring the human brain - Includes timely, key topics, providing an excellent overview of the field in a thematically structured one-stop shop location - Moves from an alphabetical structure to a systems/topic approach that is more fruitful for specialized readers and allows easier serendipity to less expert readers

Digital Twins for Smart Cities and Villages provides a holistic view of digital twin technology and how it can be deployed to develop smart cities and smart villages. Smart manufacturing, smart healthcare, smart education, smart agriculture, smart rural solutions, and related methodologies using digital twins are discussed, including challenges in deployment, their solutions and future roadmaps. This knowledge, enriched by a variety of case studies presented in the book, may empower readers with new capabilities for new research as well as new tasks and strategies for practical implementation and real-world problem solving.The book is thoughtfully structured, starting from the background of digital twin concepts and basic know-how to serve the needs of those new to the subject. It continues with implementation to facilitate and improve management in several urban contexts, infrastructures, and more. Global case study assessments further provide a deep characterization of the state-of-the-art in digital twin in urban and rural contexts. - Uniquely focuses on applications for smart cities and villages, including smart services for health, education, mobility, and agriculture - Provides use cases and practical deployment of research involved in the emerging uses of digital twins - Discusses all pertinent issues, challenges, and possible solutions instrumental in implementing digital twins smart solutions in this context - Edited and authored by a global team of experts in their given fields

Advanced Applications of Biobased Materials: Food, Biomedical, and Environmental Applications brings together cutting-edge developments in the preparation and application of biobased materials. This book begins by providing an overview of biobased materials, their classification, and their physical and chemical modifications. This is followed by a section covering the latest techniques in fabrication, processing, and characterization. Subsequent chapters are grouped by application area, offering insights into advanced and emerging utilizations of biobased materials in food, biomedical, environmental, and other industrial applications. The final part of the book highlights other key considerations, including life cycle assessment, circular economy, sustainability, and future potential. - Presents processing methods, characterization techniques, and the latest advances in biobased materials - Focuses on advanced and emerging applications of biobased materials in three key areas – food, biomedicine and the environment - Considers sustainability issues relating to biobased materials, including environmental impact, lifecycle assessment and the circular economy

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. - 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers - Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field - Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily - Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

Biofuels and Bioenergy: A Techno-Economic Approach provides an in-depth analysis of the economic aspects of biofuels production from renewable feedstock. Taking a biorefinery approach, the book analyzes a wide range of feedstocks, processes and products, including common biofuels such as bioethanol, biobutanol, biooil and biodiesel, feedstocks such as lignocellulosic biomass, non-edible feedstocks like vegetable oils, algae and microbial lipids, and solid and liquid wastes, performance assessments of biodiesel in diesel engine, and the latest developments in catalytic conversion and microbial electrosynthesis technologies. This book offers valuable insights into the commercial feasibility of biofuels products for researchers and students working in the area of bioenergy and renewable energy, but it is also ideal for practicing engineers in the biorefinery and biofuel industry who are looking to develop commercial products. - Focuses on an in-depth, techno-economic analysis of biofuel and bioenergy products, including all important feedstocks, processes and products, all of which are supported by industry case studies - Includes environmental impacts and lifecycle assessments of biofuels production alongside techno-economic analyses - Provides a critical guide to assessing the commercial viability and feasibility of bioenergy production from renewable sources

Offering an authoritative, multidisciplinary approach to the complex issues associated with neuromuscular disease, Neuromuscular Disorders, 2nd Edition, provides the latest tools and strategies for minimizing disability and maximizing quality of life. Dr. Tulio Bertorini, an expert in clinical neuromuscular care, and a team of world-renowned contributors cover all management and therapeutic considerations regarding the full range of neuromuscular disorders and resulting complications. - Provides comprehensive coverage of evaluation and diagnosis, treatments, and outcomes, including the latest management tools and targeted therapeutic strategies. - Includes the latest updates in the field: genetic causes of hereditary disease, new autoimmune diseases, promising new therapies such as antisense oligonucleotides and gene therapies, and more. - Features numerous drug tables, treatment algorithms, and clinical images throughout to aid in diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders. - Discusses the importance of the hypothalamus in human growth and development - Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders - Includes metabolic and eating disorders - Identifies mechanisms of disease action and etiology - Provides best practice information for assessment and treatment

Encyclopedia of Mycology, Two Volume Set provides a broad and multidisciplinary overview of a subject whose importance in an ecosystem is becoming more and more universally accepted with its close links to botany, microbiology, biotechnology and medicine. While there are many subject-specific works available on the topics presented, from a multidisciplinary point-of-view it is difficult to find a reliable and updated source such as this one. This work is unique in that it is a one-stop-shop on every topic area of this exciting field. - Offers students and researchers a one-stop shop with access to a wealth of information on multiple subject areas currently only available in scattered or non-technical sources - Provides an authoritative resource authored by outstanding scientists in the field who cover a range of disciplines - Written in a practical and unified language, can be used for teaching or serve as a resource for researchers and managers

Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. - Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status - Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium

Musculoskeletal Tissue Engineering introduces the fundamental concepts and translational applications of musculoskeletal tissue engineering, in combination with emerging technologies and materials. Sections discuss Tissues and Technologies, covering a range of musculoskeletal tissues, including bone, cartilage, ligament and more. Each chapter in this section details core tissue engineering principles specific to each tissue type. Next, a Technologies section looks at the range of biomaterials used in musculoskeletal tissue engineering, focusing on biocompatibility of materials and interactions at the material-tissue interface. Other chapters cover nanotechnology, 3D printing, gene therapy, tissue chips, and more. This book offers an advanced reference text for researchers in biomedical engineering, materials science and regenerative medicine. - Details various materials and cutting-edge technologies for musculoskeletal tissue engineering - Covers a range of musculoskeletal tissues, including bone, cartilage, ligament, tendon, meniscus, and more - Provides a balance between basic concepts and translational applications for a broad audience

An ideal resource for both pediatricians and endocrinologists, Sperling's Pediatric Endocrinology, 5th Edition, brings you fully up to date with accelerating research; new discoveries in metabolic, biochemical and molecular mechanisms; and the resulting advances in today's clinical care. The editorial team of world-renowned pediatric endocrinologists led by Dr. Mark Sperling, as well as expert contributing authors, cover comprehensive and current aspects of both basic science and clinical practice. Whether you're preparing for certification or have extensive clinical experience, this detailed, authoritative reference helps you increase your knowledge and determine the best possible course for every patient. - Delivers trusted guidance in every area of the field: including Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests. - Features new topics such as transgender issues in children and adolescents and endocrinology of pregnancy, the fetus and the placenta. - Offers expert coverage of hot topics such as disorders of sexual development, molecular basis of endocrine disorders, hypoglycemia in newborns and infants; neonatal and other monogenic forms of diabetes; Type I and Type II diabetes and their treatment with new insulins together with the progress in an artificial pancreas and new medications for T2DM in adolescents; the obesity epidemic and role of bariatric surgery; and advances toward personalized medicine. - Includes easy-to-follow algorithms and numerous quick-reference tables and boxes in every clinical chapter, plus interactive questions online for self-assessment. - Offers state-of-the-art information and fresh perspectives from new and award-winning authors in such areas as disorders of growth, multiple endocrine tumors, and puberty and its disorders in girls and boys.

3D and 4D Printing of Polymer Nanocomposite Materials: Processing, Applications, and Challenges covers advanced 3D and 4D printing processes and the latest developments in novel polymer-based printing materials, thus enabling the reader to understand and benefit from the advantages of this groundbreaking technology. The book presents processes, materials selection, and printability issues, along with sections on the preparation of polymer composite materials for 3D and 4D printing. Across the book, advanced printing techniques are covered and discussed thoroughly, including fused deposition modeling (FDM), selective laser sintering (SLS), selective laser melting (SLM), electron beam melting (EBM), inkjet 3D printing (3DP), stereolithography (SLA), and 3D plotting. Finally, major applications areas are discussed, including electronic, aerospace, construction and biomedical applications, with detailed information on the design, fabrication and processing methods required in each case. - Provides a thorough, clear understanding of polymer preparation techniques and 3D and 4D printing processes, with a view to specific applications - Examines synthesis, formation methodology, the dispersion of fillers, characterization, properties, and performance of polymer nanocomposites - Explores the possibilities of 4D printing, covering the usage of stimuli responsive hydrogels and shape memory polymers

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. - Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. - Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. - Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. - Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry - Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets - Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Nanocolloids: A Meeting Point for Scientists and Technologists presents an easy-to-read approach to current trends in nanoscale colloid chemistry, which offers relatively simple and economically feasible ways to produce nanomaterials. Nanocolloids have been the subjects of major development in modern technology, with many current and future applications. The book helps scientists and technologists to understand the different aspects of modern nanocolloid science. It outlines the underlying fundamental principles of nanocolloid science and covers applications ranging from emulsions to dispersions and suspensions. You will find details on experimental techniques and methods for the synthesis and characterization of nanocolloids, including the latest developments in nanoemulsions and nanoparticles. - Edited by leading academics with over 10 years'experience in the field of colloid and surfactant science - Each chapter is authored by recognized experts in the field - Outlines the underlying fundamental science behind nanocolloids - Provides comprehensive coverage of current topics and potential applications in nanocolloid science - Presents a multidisciplinary approach to help chemical engineers, chemists, physicists, materials scientists and pharmacologists, form an in-depth understanding of nanocolloid science

Dr. Iglesia has created an issue devoted to pelvic floor disorders that has a strong focus on the evidence behind current treatments and diagnostic methods. The authors are top experts in their areas and have contributed reviews on the most important topics in pelvic floor disorders, including Stress Urinary Incontinence; Urge Urinary Incontinence; Pelvic Organ Prolapse Native Tissue repairs; Pelvic Organ Prolapse Vaginal and Laparoscopic Mesh; Fecal Incontinence; PFDR Pelvic Floor Disorders Registry; Ultrasound Imaging of the Pelvic Floor; and Childbirth/Pelvic Floor Epidemiology to name a few.

This volume of Progress in Brain Research focuses on Sensorimotor Rehabilitation. - This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields

Atlas of Head and Neck Pathology delivers authoritative, highly visual guidance for effectively and accurately diagnosing a wide range of head and neck problems. This comprehensive resource features extensive, high-quality images depicting the histologic, immunohistochemical, cytologic, and diagnostic imaging appearance of every type of head and neck pathology. With a consistent, practical organization and succinct, bulleted format, the Atlas continues to be the resource general pathologists and specialists count on for reliable, easy-to-find answers. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. - Glean all essential, current, need-to-know information with sweeping revisions that include additional images shown in the frozen section, more content on odontogenic lesions and neoplasms, and inclusion of newly described entities such as igG-associated salivary gland diseases, mammary analog secretory carcinoma, and more. - Review expanded coverage of critical areas with additional chapters on oral cavity and oropharynx, nasopharynx, and neck. - Apply the most current staging of cancers from College of American Pathologists (TNM) and American Joint Committee on Cancer (AJCC). - Interpret the findings you're likely to see in practice with the aid of high-quality images now available online for review or download. - Take it with you anywhere! With Expert Consult, you'll have access to the full text, online, and as an eBook - at no additional cost!

• Manual indispensable para todo aquel profesional que desarrolle su actividad clínica en cualquier aspecto relacionado con el parto. • Lo atractivo y definitorio de esta obra se refleja en dos características fundamentales: la presencia de un equipo de autores multidisciplinar y el abordaje integral de todos los procesos relacionados con el parto. Así, el director de la obra, el profesor Juan Miguel Martínez Galiano reúne a más de 20 colaboradores con distintos perfiles profesionales (obstetras y ginecólogos, pediatras, matrones) pertenecientes a diferentes plazas universitarias (Valencia, País Vasco, Madrid, Jaén, Santiago de Compostela o Granada). • El Manual trata de forma detallada y clara todas las situaciones que pueden darse en una sala de partos, abordándose medicación y dosis, prevención de posibles complicaciones, técnicas, suturas, analgesia durante el parto, así como el cuidado del recién nacido y la introducción y seguimiento de la lactancia materna. • Pesentación muy clara y didáctica, de lectura ágil con un diseño a dos colores y un pliego en color con las imágenes más destacadas. • La obra cuenta con material online disponible en castellano en www.studentconsult.es: vídeos de procedimientos y maniobras, galería de imágenes, casos clínicos y presentaciones didácticas.

Nueva edición de la obra de referencia en Medicina Interna en español, dirigida por el profesor Rozman y co-dirigida por el profesor Cardellach, cuenta con la colaboración de 400 expertos en cada área, que pertenecen a las principales facultades y hospitales de España, Latinoamérica y otros países. La estructura del libro constituye su fundamento y su clave del éxito y es una característica diferencial respecto a otros tratados. La obra sintetiza los temas fundamentales de este campo, como la etiología, cuadro clínico, diagnóstico, pronóstico, prevención y tratamiento de las enfermedades internas. Mantiene un gran equilibrio entre un enfoque práctico y académico, por una parte, y, por otro, exhaustivo y riguroso.Editada por primera vez a cuatro colores se presenta en dos volúmenes y 20 secciones.Asimismo, incorpora un mayor número de tablas y figuras, que sintetizan los conceptos básicos de aprendizaje. Todos los capítulos han sido rigurosamente actualizados, se han incluido capítulos nuevos de conceptos transversales en la medicina interna (enfermedades de la mujer, curas paliativas, abordaje sociosanitario y papel del internista en los procesos quirúrgicos) y se aportan novedades diagnósticas o terapéuticas, como la utilidad del FibroScan en hepatitis crónicas, nuevas clasificaciones para las epilepsias,esclerosis múltiple, enfermedad de Alzheimer, revisión profunda de los fundamentos del diagnóstico hematológico, epidemia de infección por E. coli en Alemania o terapias y su relación con el sistema inmunológico, entre otras.Asimismo, incluye unos apéndices de gran utilidad, con tablas de referencia y valores normales de pruebas de laboratorio, así como un glosario de abreviaturas. La obra por primera vez da acceso a la página web www.farrerasrozman.com, donde el estudiante, el docente o el profesional podrá acceder a herramientas de autoevaluación con más de 2.500 preguntas, galería de imágenes, y todas las tablas de referencia y los valores normales de pruebas de laboratorio contenidas en el libro.

Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 22 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2009. • Covers the heterocyclic literature published in 2009 • Includes specialized reviews • Features contributions from leading researchers in their fields