11 results on '"Buja, Paolo"'
Search Results
2. Intermediate Clinical and Hemodynamic Outcomes After Transcatheter Aortic Valve Implantation.
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D'Onofrio A, Facchin M, Besola L, Manzan E, Tessari C, Bizzotto E, Bianco R, Tarantini G, Napodano M, Fraccaro C, Buja P, Covolo E, Yzeiraj E, Pittarello D, Isabella G, Iliceto S, and Gerosa G
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- Aged, 80 and over, Aortic Valve Stenosis mortality, Aortic Valve Stenosis physiopathology, Female, Follow-Up Studies, Hospital Mortality trends, Humans, Italy epidemiology, Male, Retrospective Studies, Survival Rate trends, Time Factors, Treatment Outcome, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Hemodynamics physiology, Postoperative Complications epidemiology, Transcatheter Aortic Valve Replacement methods
- Abstract
Background: Concerns still exist regarding long-term results and freedom from valve-related adverse events in transcatheter aortic valve implantation (TAVI). The aim of this single-center retrospective study was to assess intermediate-term (up to 5-year) clinical and hemodynamic outcomes in patients undergoing TAVI., Methods: From 2007 through 2013, 338 consecutive patients underwent TAVI at our institution. Preoperative variables were defined according to the European System for Cardiac Operative Risk Evaluation (EuroSCORE) definitions, and outcomes were reported according to the Valve Academic Research Consortium (VARC)-2 definitions. Multivariate logistic regression analysis was performed to identify independent predictors of mortality at follow-up., Results: transfemoral (TF) and transapical (TA) TAVI were performed in 233 (69%) and 105 (31%) patients, respectively. All-cause 30-day mortality was 4.4%, with no differences between TA and TF procedures. Thirty-day cardiovascular death, stroke, and myocardial infarction were not different between groups. The acute kidney injury (AKI) rate was higher in the TA group (30.5% versus 11.2%; p < 0.001). Access-related complications were more frequent in the TF group (36.1% versus 11.4%; p < 0.001). Mean follow-up was 22.3 ± 17.8 months (range, 1-74 months). Overall survival rates at 1, 3, and 5 years were 85.5% ± 2.1%, 69.9% ± 3.2%, and 61% ± 4.3%, respectively. Independent predictors of all-cause mortality at follow-up were previous myocardial infarction (odds ratio [OR], 2.7), any grade of paravalvular leak (PVL) (OR, 2.5), and AKI (OR, 3.1). Mean gradient and effective orifice area at follow-up were 10.7 ± 12.0 mm Hg and 1.1 ± 0.9 cm(2)/m(2), respectively., Conclusions: Our data show that TAVI has good early and intermediate-term clinical and hemodynamic outcomes in high-risk or inoperable patients with severe symptomatic aortic valve stenosis. PVL of any grade has a significant impact on survival., (Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
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- 2016
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3. Non-culprit coronary vasospasm in a woman affected by Churg-Strauss syndrome presenting with ST-elevation myocardial infarction.
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D'Amico G, Nai Fovino L, Cucchini U, Cacciavillani L, Iliceto S, and Buja P
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- Diagnosis, Differential, Female, Humans, Middle Aged, Radiography, Churg-Strauss Syndrome complications, Churg-Strauss Syndrome diagnostic imaging, Coronary Vasospasm complications, Coronary Vasospasm diagnostic imaging, Myocardial Infarction complications, Myocardial Infarction diagnostic imaging
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- 2014
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4. Clinical outcome of patients with de novo coronary bifurcation lesions treated with the Tryton Side Branch Stent. The SAFE-TRY prospective multicenter single arm study.
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Tarantini G, La Vecchia L, Galli M, Favero L, D'Amico G, Buja P, Russo F, Cabianca E, Napodano M, Musumeci G, Franceschini E, Grassi G, Pavei A, Bonmassari R, Cernetti C, Spedicato L, Caprioglio F, Reimers B, and Isabella G
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- Aged, Angioplasty, Balloon, Coronary statistics & numerical data, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease epidemiology, Coronary Restenosis epidemiology, Coronary Thrombosis epidemiology, Coronary Vessels pathology, Drug-Eluting Stents statistics & numerical data, Feasibility Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Registries statistics & numerical data, Stents statistics & numerical data, Treatment Outcome, Angioplasty, Balloon, Coronary instrumentation, Coronary Artery Disease therapy, Drug-Eluting Stents adverse effects, Stents adverse effects
- Abstract
Background: Coronary bifurcation lesions represent a difficult problem regularly confronting interventional cardiologist, in part due to the lack of dedicated device., Objective: To investigate the feasibility, safety and effectiveness of the Tryton Side Branch Stent (Tryton Medical, Durham, NC, USA), a dedicated bare metal stent deployed in conjunction with a standard drug-eluting stent to treat bifurcation lesions., Methods: The SAFE-TRY is a prospective single arm multicenter registry including patients with de novo bifurcation lesions in native coronary arteries and syntax score <32. The primary endpoint was target vessel failure (TVF) at 30 days that comprised cardiac death, target vessel myocardial infarction and clinically driven target vessel revascularization. Secondary endpoints included device, angiographic and procedural success, 9-month major adverse cardiac and cerebrovascular event (MACCE), and stent thrombosis (ST) rates (ClinicalTrials.gov identifier: NCT01174433)., Results: Among 252 enrolled patients, 24% had diabetes and 35.3% unstable angina. True bifurcation lesions involving both branches occurred in 96.8% of cases with Medina classification 1.1.1 in 62%. The left anterior descending artery and the left main were treated in 70% and 8.3% of the patients, respectively. A 6 Fr guide catheter was used in 61% of the cases. Device, angiographic and procedural success rates were 99.6%, 99.6% and 97.2% respectively. The 30-day TVF was 2.8%; the 9-month MACCE rate was 13.7%, with target lesion revascularization being 4.4%. No definite ST occurred., Conclusions: This prospective, multicenter study confirmed the feasibility, safety and effectiveness of the Tryton Side Branch Stent to treat patients with de novo complex bifurcation lesions., (© 2013 Elsevier Ireland Ltd. All rights reserved.)
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- 2013
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5. Transcatheter aortic valve implantation and bleeding: focus on Valve Academic Research Consortium-2 classification.
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Tarantini G, Gasparetto V, Napodano M, Frigo AC, Fraccaro C, Buja P, D'Onofrio A, D'Amico G, Barioli A, Baritussio A, Facchin M, Dariol G, Isabella G, Gerosa G, and Iliceto S
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- Aged, Aged, 80 and over, Female, Hemorrhage mortality, Humans, Male, Predictive Value of Tests, Prevalence, Prospective Studies, Registries, Survival Rate, Transcatheter Aortic Valve Replacement mortality, Treatment Outcome, Hemorrhage etiology, Transcatheter Aortic Valve Replacement adverse effects
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- 2013
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6. Management and outcome of spontaneous coronary artery dissection: conservative therapy versus revascularization.
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Buja P, Coccato M, Fraccaro C, Tarantini G, Isabella G, Almamary A, Dariol G, Panfili M, Iliceto S, and Napodano M
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- Female, Humans, Male, Middle Aged, Stents, Treatment Outcome, Vascular Diseases therapy, Vascular Surgical Procedures, Coronary Vessel Anomalies therapy, Vascular Diseases congenital
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- 2013
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7. Gender-related differences of diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents: a real-life multicenter experience.
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Buja P, D'Amico G, Facchin M, Barioli A, Napodano M, Capodanno D, Musumeci G, Frigo AC, Saia F, Menozzi A, De Benedictis M, Lee MS, Lettieri C, Tamburino C, Sardella G, Isabella G, and Tarantini G
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- Aged, Cohort Studies, Diabetes Mellitus diagnosis, Female, Humans, Male, Middle Aged, Prospective Studies, Registries, Retrospective Studies, Diabetes Mellitus physiopathology, Diabetes Mellitus surgery, Drug-Eluting Stents, Percutaneous Coronary Intervention methods, Sex Characteristics
- Abstract
Background: Gender-based differences in diabetic patients are understudied in the field of percutaneous coronary intervention (PCI) with drug-eluting stents., Methods: Data were obtained from a multicenter registry of 2420 consecutive patients with diabetes mellitus (DM) who underwent PCI with paclitaxel- or sirolimus-eluting stents between 2003 and 2009. Among them, 679 (28.1%) women were compared to 1741 (71.9%) men in terms of clinical aspects and major adverse cardiac events (MACE), including all-cause death, myocardial infarction (MI) and target lesion revascularization (TLR). Target vessel revascularization (TVR) and any revascularization were also reported., Results: Women were less numerous, older, used more insulin and showed more tortuous coronary arteries, while men were more frequently smokers and received larger stents. At the median follow-up of 24.3 months (interquartile range 12.3-39.7), MACE, TVR and any revascularization did not significantly differ between females and males (19.9% vs 18.7%, 12.2% vs 13.4%, 14.1% vs 15.1%, respectively). At multivariable analysis of the overall cohort, female gender was not a predictor of MACE (hazard ratio [HR] 1.02, 95% confidence interval [CI] 0.92-2.36, p=0.11), death (HR 1.04, 95% CI 0.84-1.24, p=0.86), MI (HR 1.48, 95% CI 0.92-2.36, p=0.11), and TLR (HR 1.14, 95% CI 0.85-1.52, p=0.38)., Conclusion: In this registry of diabetic patients treated by drug-eluting stents, women were less represented, older and needed more insulin compared to men who, on the other hand, received larger stents. Gender-related outcomes were similar and female sex did not predict MACE., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
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- 2013
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8. Chronic kidney disease and percutaneous coronary interventions with drug-eluting stents: does the K/DOQI classification matter?
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Favaretto E, Valente L, Napodano M, Frigo AC, Buja P, Ronco F, Cruz DN, Xhaxho J, Naso P, Ronco C, Isabella G, Iliceto S, and Tarantini G
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- Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Renal Insufficiency, Chronic diagnosis, Drug-Eluting Stents, Percutaneous Coronary Intervention methods, Renal Insufficiency, Chronic classification, Renal Insufficiency, Chronic surgery
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- 2013
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9. Time-dependent detrimental effects of distal embolization on myocardium and microvasculature during primary percutaneous coronary intervention.
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Napodano M, Peluso D, Marra MP, Frigo AC, Tarantini G, Buja P, Gasparetto V, Fraccaro C, Isabella G, Razzolini R, and Iliceto S
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- Aged, Female, Humans, Male, Microvessels, Middle Aged, Necrosis etiology, Prospective Studies, Time Factors, Cardiomyopathies etiology, Embolism complications, Intraoperative Complications etiology, Myocardial Infarction surgery, Myocardium pathology, Percutaneous Coronary Intervention, Vascular Diseases etiology
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Objectives: The authors sought to investigate the impact of distal embolization (DE) on myocardial damage and microvascular reperfusion, according to time-to-treatment, using contrast-enhanced cardiac magnetic resonance (CE-CMR)., Background: DE, occurring during primary percutaneous coronary intervention (p-PCI), appears to increase myocardial necrosis and to worsen microvascular perfusion, as shown by surrogate markers. However, data regarding the behavior of DE on jeopardized myocardium, and in particular on necrosis extent and distribution, are still lacking., Methods: In 288 patients who underwent p-PCI within 6 h from symptom onset, the authors prospectively assessed the impact of DE on infarct size and microvascular damage, using CE-CMR. The impact of DE was assessed according to time-to-treatment: for group 1, <3 h; for group 2, ≥3 and ≤6 h., Results: DE occurred in 41 (14.3%) patients. Baseline clinical characteristics were not different between the 2 groups. At CE-CMR, patients with DE showed larger infarct size (p = 0.038) and more often transmural necrosis compared with patients without DE (p = 0.008) when time-to-treatment was <3 h, but no impact was proven after this time (p = NS). Patients with DE showed more often microvascular obstruction, as evaluated at first-pass enhancement, than patients without DE (100% vs. 66.5%, p = 0.001) up to 6 h from symptom onset., Conclusions: These findings suggest that the detrimental impact of DE occurring during p-PCI on myocardial damage is largely influenced by ischemic time, increasing the extent of necrosis in patients presenting within the first hours after symptom onset, and having limited or no impact after this time window., (Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
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- 2012
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10. Myocardial edema underlies dynamic T-wave inversion (Wellens' ECG pattern) in patients with reversible left ventricular dysfunction.
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Migliore F, Zorzi A, Marra MP, Basso C, Corbetti F, De Lazzari M, Tarantini G, Buja P, Lacognata C, Thiene G, Corrado D, and Iliceto S
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- Aged, Aged, 80 and over, Contrast Media, Diagnosis, Differential, Edema, Cardiac etiology, Edema, Cardiac physiopathology, Female, Humans, Male, Middle Aged, Syndrome, Ventricular Dysfunction, Left etiology, Ventricular Dysfunction, Left physiopathology, Edema, Cardiac diagnosis, Electrocardiography, Magnetic Resonance Imaging methods, Ventricular Dysfunction, Left diagnosis
- Abstract
Background: The Wellens' electrocardiogram (ECG) pattern of dynamic T-wave inversion in the anterior leads is observed in clinical conditions characterized by reversible left ventricular (LV) dysfunction (stunned myocardium), either ischemic or nonischemic. The pathophysiologic basis of this ECG pattern remains to be elucidated., Objective: The purpose of this study was to report the contrast-enhanced cardiac magnetic resonance (CE-CMR) findings in 4 cases of Wellens' ECG pattern associated with transient LV dysfunction from a variety of clinical conditions such as myocardial bridge, coronary artery dissection, cholecystitis, and takotsubo syndrome., Methods: All patients underwent CE-CMR at the time of acute clinical manifestations and after 6 to 8 weeks of follow-up to assess the presence and dynamics of LV myocardial changes., Results: In all patients, the Wellens' ECG abnormalities were associated with increased signal intensity of the LV myocardium on T2-weighted sequences suggesting myocardial edema, in the absence of late enhancement on postcontrast sequences. Repolarization abnormalities and myocardial edema had a parallel time course with persistence beyond recovery of mechanical abnormalities. T-wave inversion was associated with transient prolongation of the QTc interval in all cases., Conclusion: The study results suggest that myocardial edema rather than systolic dysfunction underlies the Wellens' ECG pattern, regardless of the causative mechanism., (Copyright © 2011 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
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- 2011
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11. Moderate-to-severe ischemic mitral regurgitation and multivessel coronary artery disease: Impact of different treatment on survival and rehospitalization.
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Buja P, Tarantini G, Del Bianco F, Razzolini R, Bilato C, Ramondo A, Napodano M, Isabella G, Gerosa G, and Iliceto S
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- Aged, Chronic Disease, Coronary Artery Bypass, Coronary Artery Disease complications, Coronary Artery Disease mortality, Female, Follow-Up Studies, Humans, Male, Mitral Valve surgery, Mitral Valve Insufficiency complications, Mitral Valve Insufficiency mortality, Myocardial Ischemia complications, Myocardial Ischemia mortality, Patient Readmission, Severity of Illness Index, Survival Rate, Coronary Artery Disease therapy, Mitral Valve Insufficiency therapy, Myocardial Ischemia therapy
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Background: The outcome of moderate-to-severe ischemic mitral regurgitation with multivessel coronary artery disease is still debated. We analysed the effect of different treatments, i.e. medical therapy (MT), coronary artery by-pass grafting (CABG) alone and CABG with mitral valve surgery (MVS), on the survival and rehospitalization of these patients., Methods: Between 1990 and 2002, we identified 111 consecutive patients, aged 73+/-8 years, with chronic moderate-to-severe mitral regurgitation and multivessel coronary artery disease at cardiac catheterization, in absence of primary valve disease. Twenty-two patients were treated by MT, 50 by CABG and 39 by CABG+MVS. Overall, the median clinical and echocardiographic follow-ups were 34.9 and 14.6 months, respectively., Results: Groups differed significantly (p < 0.03) for left ventricular end-diastolic volume index (MT 153+/-54, CABG 125+/-35, CABG + MVS 129+/-38, ml/m2), ejection fraction (MT 35+/-14, CABG 38+/-13, CABG + MVS 50+/-14, %) and mammary artery graft use (CABG 60, CABG + MVS 74, %). While in-hospital mortality was higher in surgical patients (MT 13.6, CABG 18, CABG + MVS 17.9, %, p=0.09), 7-years mortality showed a trend in favour of CABG + MVS compared to other groups (MT 100, CABG 57, CABG + MVS 29, %, p = 0.1). After adjusting for baseline differences, CABG alone or with MVS had a 57% (HR 0.43, p = 0.005) and 53% (HR 0.47, p = 0.02) risk reduction of combined cardiac death and rehospitalization rate compared to MT. However, only CABG + MVS independently predicted mortality (risk reduction 65%, HR 0.35, p = 0.027)., Conclusions: In moderate-to-severe ischemic mitral regurgitation and multivessel coronary artery disease, surgery reduced total cardiac events but only a concomitant MVS significantly improved survival.
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- 2006
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