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Health disparities are common and a major focus of attention among health care researchers. The reasons for these disparities are several in number and broad in scope. Therefore, it will require a broad-based, multidisciplinary approach to fully understand and significantly reduce health disparities. Researchers with expertise in business and economics, public policy, education, language and communication, and social work will have to team with more traditional health researchers to achieve the desired goal. Our approach to this challenge was to develop a Health Disparities Research Group, a multidisciplinary group of university faculty with an interest in health disparities. University faculty from the disciplines mentioned above, plus others with varying amounts of research experience, have come together to form the group. In this article, we describe how this group was formed and some of its activities to assist in development of other such research teams across the nation.