1. Predictors of uncommon location of sentinel nodes in endometrial and cervical cancers
- Author
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Kadan, Yfat, Baron, Alexandra, Brezinov, Yoav, Ben Arie, Alon, Fishman, Ami, and Beiner, Mario
- Subjects
body regions ,Research Report ,Oncology ,RG1-991 ,Obstetrics and Gynecology ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Gynecology and obstetrics ,RC254-282 - Abstract
Highlights • Detection of uncommon sentinel lymph nodes (SLN) was related to lower BMI and the use of Tc99&blue dye or ICG. • Detection of SLN in the para-aortic, parametrium and pre-sacral regions was related to recent surgical year. • Detection of SLN in the para-aortic, parametrium and pre-sacral regions was also related to the presence of positive nodes. • It seems that surgical parameters as opposed to tumor characteristics are the main predictors for uncommon SLN., Objective Sentinel node mapping is widely used in the treatment of gynecologic cancers. The current study aimed to identify predictors of uncommon sentinel lymph node (SLN) locations. Methods The current study included women who were operated for endometrial or cervical cancer with attempted sentinel lymph node mapping during surgical staging. Data were collected from electronic charts. The pelvis and the external ilia and obturator basins were common node locations. Para-aortic, pre-sacral, common iliac, internal iliac, and parametrial nodes were considered uncommon locations. We conducted analyses stratified according to common, uncommon, and very uncommon (para-aortic, pre-sacral, parametrial) node location sites. Results A total of 304 women were enrolled in the current study; 15.8% had SLN in uncommon locations and 4.3% had very uncommon node locations. Body mass index (BMI) was a negative predictor for uncommon SLN locations (OR 0.88, p = 0.03). The use of either indocyanine green (ICG) or Tc99 & blue dye was an independent predictor for uncommon SLN locations (OR 8.24, p = 0.006). More recent surgeries and the presence of positive nodes were independent predictors for very uncommon node locations (OR 2.13, p = 0.011, and OR 9.3, p = 0.002, respectively). Conclusions BMI, tracer type, surgical year, and positive nodes were independent predictors for uncommon SLN locations. These findings suggest that surgical effort, technique and experience may result in better identification of uncommon SLN locations.
- Published
- 2022