1. Vitamin D rescues dysfunction of fetal endothelial colony forming cells from individuals with gestational diabetes.
- Author
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Gui J, Rohrbach A, Borns K, Hillemanns P, Feng L, Hubel CA, and von Versen-Höynck F
- Subjects
- Adult, Cell Movement, Cell Proliferation, Cells, Cultured, Colony-Forming Units Assay, Diabetes, Gestational immunology, Diabetes, Gestational pathology, Diabetes, Gestational physiopathology, Diabetic Angiopathies prevention & control, Dietary Supplements, Endothelium, Vascular immunology, Endothelium, Vascular pathology, Female, Fetal Blood, Fetal Stem Cells immunology, Fetal Stem Cells pathology, Humans, Leukocytes, Mononuclear immunology, Leukocytes, Mononuclear metabolism, Leukocytes, Mononuclear pathology, Neovascularization, Pathologic prevention & control, Pregnancy, RNA Interference, Receptors, Calcitriol agonists, Receptors, Calcitriol antagonists & inhibitors, Receptors, Calcitriol genetics, Receptors, Calcitriol metabolism, Retrospective Studies, Systemic Vasculitis prevention & control, Vitamin D metabolism, Vitamin D therapeutic use, Calcitriol metabolism, Diabetes, Gestational metabolism, Diabetic Angiopathies etiology, Endothelium, Vascular metabolism, Fetal Stem Cells metabolism, Neovascularization, Pathologic etiology, Systemic Vasculitis etiology
- Abstract
Introduction: Gestational diabetes (GDM) is associated with long-term cardiovascular and metabolic diseases in offspring. However, the mechanisms are not well understood. We explored whether fetal exposure to a diabetic environment is associated with fetal endothelial progenitor cell dysfunction, and whether vitamin D can reverse the impairment., Methods: Nineteen women with uncomplicated pregnancies and 18 women with GDM were recruited before delivery. Time to first appearance of endothelial colony forming cell (ECFC) colonies and number of ECFC colonies formed from culture of cord peripheral blood mononuclear cells were determined. Angiogenesis-related functions of ECFCs in vitro were tested in the presence or absence of vitamin D., Results: Fetal ECFCs from GDM pregnancies formed fewer colonies in culture (P = 0.04) and displayed reduced proliferation (P = 0.02), migration (P = 0.04) and tubule formation (P = 0.03) compared to uncomplicated pregnancies. Fetal ECFCs exposed to hyperglycemia in vitro exhibited less migration (P < 0.05) and less tubule formation (P < 0.05) than normoglycemic control. Vitamin D significantly improved the dysfunction of fetal ECFCs from pregnancies complicated by GDM or after exposure of healthy ECFCs to hyperglycemia., Discussion: Fetal ECFCs from GDM pregnancies or ECFCs exposed to hyperglycemia in vitro exhibit reduced quantity and impaired angiogenesis-related functions. Vitamin D significantly rescues these functions. These findings may have implications for vascular function of infants exposed to a diabetic intrauterine environment., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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